TXNDC8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.94965893
2epithelial cilium movement (GO:0003351)9.82628059
3motile cilium assembly (GO:0044458)9.76863435
4spermatid development (GO:0007286)9.70220109
5axonemal dynein complex assembly (GO:0070286)9.66152965
6cilium or flagellum-dependent cell motility (GO:0001539)8.84839947
7regulation of cilium movement (GO:0003352)8.03690770
8cilium movement (GO:0003341)7.84854764
9single fertilization (GO:0007338)7.65980360
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.45936999
11sperm capacitation (GO:0048240)7.04828005
12synaptonemal complex organization (GO:0070193)6.91368995
13synaptonemal complex assembly (GO:0007130)6.87175597
14male meiosis (GO:0007140)6.86636856
15negative regulation of inclusion body assembly (GO:0090084)6.86292571
16piRNA metabolic process (GO:0034587)6.82266748
17microtubule depolymerization (GO:0007019)6.76957633
18* spermatogenesis (GO:0007283)6.72623964
19* male gamete generation (GO:0048232)6.70293538
20organic cation transport (GO:0015695)6.66224967
21fertilization (GO:0009566)6.39511647
22* gamete generation (GO:0007276)6.15661279
23calcium ion-dependent exocytosis (GO:0017156)5.78623341
24regulation of inclusion body assembly (GO:0090083)5.69970023
25germ cell development (GO:0007281)5.36333873
26* cellular process involved in reproduction in multicellular organism (GO:0022412)5.24637764
27cell recognition (GO:0008037)5.21876550
28chromosome condensation (GO:0030261)5.17922261
29spermatid nucleus differentiation (GO:0007289)5.16567500
30ventricular system development (GO:0021591)5.05179838
31DNA packaging (GO:0006323)4.86878946
32* multicellular organismal reproductive process (GO:0048609)4.83892931
33chromosome organization involved in meiosis (GO:0070192)4.72910201
34regulation of microtubule-based movement (GO:0060632)4.68778448
35male meiosis I (GO:0007141)4.54751358
36seminiferous tubule development (GO:0072520)4.51731150
37DNA methylation involved in gamete generation (GO:0043046)4.50642033
38microtubule severing (GO:0051013)4.41007540
39chaperone-mediated protein complex assembly (GO:0051131)4.21723231
40single strand break repair (GO:0000012)4.11579607
41sexual reproduction (GO:0019953)4.10348930
42meiotic nuclear division (GO:0007126)4.03317646
43sequestering of actin monomers (GO:0042989)4.03030643
44left/right pattern formation (GO:0060972)4.02557101
45protein K11-linked deubiquitination (GO:0035871)3.92431236
46* multicellular organismal development (GO:0007275)3.90986961
47microtubule polymerization or depolymerization (GO:0031109)3.65171765
48meiosis I (GO:0007127)3.58995566
49genitalia morphogenesis (GO:0035112)3.44106951
50regulation of spindle checkpoint (GO:0090231)3.34629176
51polyol catabolic process (GO:0046174)3.32803736
52GTP biosynthetic process (GO:0006183)3.29108352
53nucleoside diphosphate phosphorylation (GO:0006165)3.26667616
54positive regulation of macrophage activation (GO:0043032)3.20646559
55protein localization to cilium (GO:0061512)3.19923203
56alditol metabolic process (GO:0019400)3.16474260
57meiotic cell cycle (GO:0051321)3.14498823
58monoubiquitinated protein deubiquitination (GO:0035520)3.12633210
59protein polyglutamylation (GO:0018095)3.04822313
60glycolytic process (GO:0006096)3.02974330
61interferon-gamma secretion (GO:0072643)3.01046116
62amino-acid betaine transport (GO:0015838)2.98250913
63carnitine transport (GO:0015879)2.98250913
64UTP biosynthetic process (GO:0006228)2.91304867
65protein refolding (GO:0042026)2.89080719
66synapsis (GO:0007129)2.88139714
67nucleus organization (GO:0006997)2.84659102
68mitotic sister chromatid cohesion (GO:0007064)2.84522766
69* glycerol ether metabolic process (GO:0006662)2.83489464
70carnitine transmembrane transport (GO:1902603)2.80033651
71cilium organization (GO:0044782)2.77057518
72cilium morphogenesis (GO:0060271)2.75859800
73glycerol metabolic process (GO:0006071)2.72110901
74centriole assembly (GO:0098534)2.71767068
75cilium assembly (GO:0042384)2.68731543
76intraciliary transport (GO:0042073)2.68243406
77meiotic cell cycle process (GO:1903046)2.67635356
78polyamine biosynthetic process (GO:0006596)2.65865104
79regulation of cilium assembly (GO:1902017)2.65460072
80microtubule-based movement (GO:0007018)2.64607380
81UTP metabolic process (GO:0046051)2.63181916
82lactate metabolic process (GO:0006089)2.62567140
83* ether metabolic process (GO:0018904)2.58948725
84RNA destabilization (GO:0050779)2.57028623
85* cellular component assembly involved in morphogenesis (GO:0010927)2.56497424
86axoneme assembly (GO:0035082)2.46932588
87negative regulation of organelle assembly (GO:1902116)2.41891104
88chromatin silencing (GO:0006342)2.41782856
89RNA localization (GO:0006403)2.31738261
90cell wall macromolecule catabolic process (GO:0016998)14.6259055
91cell wall macromolecule metabolic process (GO:0044036)14.6259055
92fusion of sperm to egg plasma membrane (GO:0007342)14.5777061
93sperm motility (GO:0030317)13.8423804
94acrosome reaction (GO:0007340)12.2674967
95sperm-egg recognition (GO:0035036)12.0309652
96multicellular organism reproduction (GO:0032504)11.6199931
97plasma membrane fusion (GO:0045026)11.0880222
98* acrosome assembly (GO:0001675)10.9314067
99binding of sperm to zona pellucida (GO:0007339)10.8490229
100cell-cell recognition (GO:0009988)10.7555885

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.14240318
2EZH2_22144423_ChIP-Seq_EOC_Human4.22485573
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.02578310
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.50469813
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.08161580
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.05229341
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.82717163
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.32647582
9VDR_22108803_ChIP-Seq_LS180_Human2.21555846
10ZNF274_21170338_ChIP-Seq_K562_Hela2.20868727
11EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.10737518
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.06966468
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06809255
14PCGF2_27294783_Chip-Seq_ESCs_Mouse1.99532595
15KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.94873366
16CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.90180788
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84649605
18ELK4_26923725_Chip-Seq_MESODERM_Mouse1.82531330
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81783370
20CBX2_27304074_Chip-Seq_ESCs_Mouse1.76311366
21STAT1_17558387_ChIP-Seq_HELA_Human1.74300383
22TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.73031881
23MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.71557967
24SOX2_22085726_ChIP-Seq_NPCs_Mouse1.66015333
25TAL1_26923725_Chip-Seq_HPCs_Mouse1.59334284
26GATA3_21867929_ChIP-Seq_CD8_Mouse1.57928222
27FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56831233
28KDM2B_26808549_Chip-Seq_REH_Human1.56019822
29KAP1_22055183_ChIP-Seq_ESCs_Mouse1.55323652
30GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.53778742
31RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.51626345
32WDR5_24793694_ChIP-Seq_LNCAP_Human1.48903172
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.43376434
34PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.40984113
35ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39993458
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38672593
37TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35493337
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34911706
39REST_21632747_ChIP-Seq_MESCs_Mouse1.32225145
40GF1_26923725_Chip-Seq_HPCs_Mouse1.31982137
41LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.29756966
42FLI1_21867929_ChIP-Seq_TH2_Mouse1.28522086
43* P53_21459846_ChIP-Seq_SAOS-2_Human1.28519362
44TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27725182
45FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.27388841
46GATA3_21867929_ChIP-Seq_TH1_Mouse1.27383627
47CBP_20019798_ChIP-Seq_JUKART_Human1.26256833
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26256833
49CRX_20693478_ChIP-Seq_RETINA_Mouse1.23613116
50RAD21_21589869_ChIP-Seq_MESCs_Mouse1.21448215
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21318350
52* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19532070
53SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19321038
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.18868310
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14634297
56CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13883577
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13881277
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12722345
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12434767
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12434767
61OCT4_18555785_Chip-Seq_ESCs_Mouse1.11570714
62P53_22387025_ChIP-Seq_ESCs_Mouse1.10957518
63PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10211462
64PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10193953
65CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09724885
66TAF15_26573619_Chip-Seq_HEK293_Human1.09156476
67SPI1_26923725_Chip-Seq_HPCs_Mouse1.07931460
68CMYC_18555785_Chip-Seq_ESCs_Mouse1.07911499
69SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.06909718
70ESET_19884257_ChIP-Seq_ESCs_Mouse1.05603307
71* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05438682
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.04515071
73SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03996964
74P300_18555785_Chip-Seq_ESCs_Mouse1.03539470
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03007581
76KLF4_18555785_Chip-Seq_ESCs_Mouse1.02365545
77RUNX1_26923725_Chip-Seq_HPCs_Mouse1.02193470
78RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02105586
79RNF2_27304074_Chip-Seq_NSC_Mouse1.00458394
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00209355
81ESRRB_18555785_Chip-Seq_ESCs_Mouse0.99564239
82GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99440762
83EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98841508
84MYC_27129775_Chip-Seq_CORNEA_Mouse0.98825962
85OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98652397
86LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98524489
87PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98251306
88JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95771335
89RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95465878
90SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94649311
91NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94246023
92NFYB_21822215_ChIP-Seq_K562_Human0.93471963
93RARA_24833708_ChIP-Seq_LIVER_Mouse0.93284879
94PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93277701
95EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93211274
96SOX2_18555785_Chip-Seq_ESCs_Mouse0.92757792
97GF1B_26923725_Chip-Seq_HPCs_Mouse0.92504863
98PU1_27457419_Chip-Seq_LIVER_Mouse0.90574124
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88921148
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.88449195

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.03315228
2MP0001929_abnormal_gametogenesis5.57828273
3MP0008877_abnormal_DNA_methylation3.91453425
4MP0002210_abnormal_sex_determination3.34503083
5MP0002161_abnormal_fertility/fecundity3.27170169
6MP0005670_abnormal_white_adipose2.89014497
7MP0001145_abnormal_male_reproductive2.81889471
8MP0000653_abnormal_sex_gland2.44186068
9MP0005410_abnormal_fertilization16.7596640
10MP0002653_abnormal_ependyma_morphology1.80438700
11MP0003646_muscle_fatigue1.72375539
12MP0004233_abnormal_muscle_weight1.64389046
13MP0005623_abnormal_meninges_morphology1.58662411
14MP0002160_abnormal_reproductive_system1.50635394
15MP0002282_abnormal_trachea_morphology1.44760468
16MP0001765_abnormal_ion_homeostasis1.13942730
17MP0002234_abnormal_pharynx_morphology1.02822304
18MP0001984_abnormal_olfaction0.94812253
19MP0008995_early_reproductive_senescence0.86495402
20MP0005647_abnormal_sex_gland0.83074323
21MP0009046_muscle_twitch0.77867667
22MP0005389_reproductive_system_phenotype0.75473745
23MP0003011_delayed_dark_adaptation0.74503001
24MP0008058_abnormal_DNA_repair0.70066906
25MP0002736_abnormal_nociception_after0.60814647
26MP0003879_abnormal_hair_cell0.58445665
27MP0005636_abnormal_mineral_homeostasis0.57670445
28MP0005503_abnormal_tendon_morphology0.56521863
29MP0004036_abnormal_muscle_relaxation0.50571427
30MP0000569_abnormal_digit_pigmentation0.47571275
31MP0005551_abnormal_eye_electrophysiolog0.46932546
32MP0001324_abnormal_eye_pigmentation0.45673124
33MP0004134_abnormal_chest_morphology0.44153951
34MP0002269_muscular_atrophy0.44050925
35MP0003115_abnormal_respiratory_system0.43854328
36MP0009250_abnormal_appendicular_skeleto0.41822255
37MP0005666_abnormal_adipose_tissue0.41789763
38MP0003950_abnormal_plasma_membrane0.41548746
39MP0005253_abnormal_eye_physiology0.41207729
40MP0003699_abnormal_female_reproductive0.40804358
41MP0004019_abnormal_vitamin_homeostasis0.40031219
42MP0002928_abnormal_bile_duct0.39995121
43MP0000604_amyloidosis0.39524176
44MP0004742_abnormal_vestibular_system0.38453010
45MP0001968_abnormal_touch/_nociception0.38122147
46MP0001270_distended_abdomen0.37461701
47MP0005174_abnormal_tail_pigmentation0.37352999
48MP0002102_abnormal_ear_morphology0.37334044
49MP0002139_abnormal_hepatobiliary_system0.36968458
50MP0001764_abnormal_homeostasis0.36528193
51MP0002909_abnormal_adrenal_gland0.34925950
52MP0009115_abnormal_fat_cell0.33726752
53MP0004133_heterotaxia0.33473571
54MP0000358_abnormal_cell_content/0.33202058
55MP0000534_abnormal_ureter_morphology0.31781563
56MP0003878_abnormal_ear_physiology0.31717900
57MP0005377_hearing/vestibular/ear_phenot0.31717900
58MP0001545_abnormal_hematopoietic_system0.30998577
59MP0005397_hematopoietic_system_phenotyp0.30998577
60MP0002971_abnormal_brown_adipose0.30920951
61MP0010094_abnormal_chromosome_stability0.30522320
62MP0006036_abnormal_mitochondrial_physio0.29596182
63MP0003329_amyloid_beta_deposits0.29195949
64MP0000015_abnormal_ear_pigmentation0.26748866
65MP0009278_abnormal_bone_marrow0.25904252
66MP0001293_anophthalmia0.24987055
67MP0003942_abnormal_urinary_system0.24781063
68MP0003787_abnormal_imprinting0.24284314
69MP0009697_abnormal_copulation0.23233592
70MP0001963_abnormal_hearing_physiology0.22769562
71MP0003786_premature_aging0.22334105
72MP0001119_abnormal_female_reproductive0.22168603
73MP0005391_vision/eye_phenotype0.22033357
74MP0005535_abnormal_body_temperature0.21450662
75MP0003633_abnormal_nervous_system0.18849692
76MP0008004_abnormal_stomach_pH0.18454075
77MP0000432_abnormal_head_morphology0.18095039
78MP0003948_abnormal_gas_homeostasis0.18068522
79MP0005423_abnormal_somatic_nervous0.17707879
80MP0002169_no_abnormal_phenotype0.17558927
81MP0002873_normal_phenotype0.17457759
82MP0002109_abnormal_limb_morphology0.16675843
83MP0004811_abnormal_neuron_physiology0.16591335
84MP0002115_abnormal_skeleton_extremities0.16442341
85MP0008057_abnormal_DNA_replication0.16269474
86MP0002108_abnormal_muscle_morphology0.16050776
87MP0000462_abnormal_digestive_system0.15730757
88MP0001348_abnormal_lacrimal_gland0.15668745
89MP0000026_abnormal_inner_ear0.15534059
90MP0006072_abnormal_retinal_apoptosis0.14590401
91MP0003111_abnormal_nucleus_morphology0.14379928
92MP0005319_abnormal_enzyme/_coenzyme0.13924444
93MP0001986_abnormal_taste_sensitivity0.13173694
94MP0003861_abnormal_nervous_system0.13172994
95MP0005365_abnormal_bile_salt0.11947098
96MP0005451_abnormal_body_composition0.11599219
97MP0002229_neurodegeneration0.11544022
98MP0002152_abnormal_brain_morphology0.11320239
99MP0004808_abnormal_hematopoietic_stem0.11155737
100MP0003385_abnormal_body_wall0.10875466

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.58973053
2Abnormal respiratory motile cilium morphology (HP:0005938)9.50826097
3Abnormal respiratory epithelium morphology (HP:0012253)9.50826097
4Abnormal ciliary motility (HP:0012262)7.70915540
5Chronic bronchitis (HP:0004469)7.62556303
6Rhinitis (HP:0012384)7.57014429
7Infertility (HP:0000789)6.82663821
8Nasal polyposis (HP:0100582)6.25493201
9Abnormality of the nasal mucosa (HP:0000433)5.11488513
10Bronchitis (HP:0012387)4.44003146
11Male infertility (HP:0003251)4.41105850
12Bronchiectasis (HP:0002110)4.35180769
13Nephronophthisis (HP:0000090)3.72332399
14Recurrent sinusitis (HP:0011108)3.48996975
15Abnormal spermatogenesis (HP:0008669)3.34432399
16Recurrent otitis media (HP:0000403)3.17780444
17Abnormality of the renal medulla (HP:0100957)2.77983696
18Medial flaring of the eyebrow (HP:0010747)2.55988816
19Tubulointerstitial nephritis (HP:0001970)2.47070101
20Recurrent bronchitis (HP:0002837)2.31634374
21Molar tooth sign on MRI (HP:0002419)2.31016099
22Abnormality of midbrain morphology (HP:0002418)2.31016099
23Impulsivity (HP:0100710)2.28089774
24Azoospermia (HP:0000027)2.22118493
25Tubular atrophy (HP:0000092)2.19928361
26Gonadotropin excess (HP:0000837)2.09960814
27Tubulointerstitial abnormality (HP:0001969)2.07112965
28Abnormal gallbladder physiology (HP:0012438)2.05256499
29Cholecystitis (HP:0001082)2.05256499
30Dynein arm defect of respiratory motile cilia (HP:0012255)13.8870606
31Absent/shortened dynein arms (HP:0200106)13.8870606
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2193459
33Absent frontal sinuses (HP:0002688)1.89881962
34Hypoplasia of the capital femoral epiphysis (HP:0003090)1.85711366
35Dyschromatopsia (HP:0007641)1.81904755
36Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.79668576
37Absent epiphyses (HP:0010577)1.79668576
38Fibular hypoplasia (HP:0003038)1.75822599
39Decreased central vision (HP:0007663)1.70207442
40Choroideremia (HP:0001139)1.69731339
41Stage 5 chronic kidney disease (HP:0003774)1.65614344
42Tubulointerstitial fibrosis (HP:0005576)1.62704797
43Aplasia/Hypoplasia of the lens (HP:0008063)1.61997080
44Short femoral neck (HP:0100864)1.60878301
45Postaxial foot polydactyly (HP:0001830)1.58245525
46Gait imbalance (HP:0002141)1.57956659
47Double outlet right ventricle (HP:0001719)1.57345575
48Congenital malformation of the right heart (HP:0011723)1.57345575
49Congenital primary aphakia (HP:0007707)1.57165409
50Spastic tetraparesis (HP:0001285)1.56057627
51Abnormality of renal excretion (HP:0011036)1.54215738
52Taurodontia (HP:0000679)1.54143770
53Abnormality of permanent molar morphology (HP:0011071)1.54143770
54Abnormality of the dental root (HP:0006486)1.54143770
55Chronic sinusitis (HP:0011109)1.49657277
56Abnormality of dentin (HP:0010299)1.49023958
57Short ribs (HP:0000773)1.47562277
58Abnormality of molar morphology (HP:0011070)1.45823685
59Abnormality of molar (HP:0011077)1.45823685
60Hemorrhage of the eye (HP:0011885)1.45521286
61Congenital hepatic fibrosis (HP:0002612)1.44984433
62Abnormality of the dental pulp (HP:0006479)1.41902150
63Bundle branch block (HP:0011710)1.41510038
64Abnormality of the renal cortex (HP:0011035)1.41139772
65Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.40376602
66Polydipsia (HP:0001959)1.39992465
67Abnormal drinking behavior (HP:0030082)1.39992465
68Neurofibrillary tangles (HP:0002185)1.37515906
69Postaxial hand polydactyly (HP:0001162)1.34747404
70Nephrogenic diabetes insipidus (HP:0009806)1.33743503
71Bile duct proliferation (HP:0001408)1.33085791
72Abnormal biliary tract physiology (HP:0012439)1.33085791
73Facial cleft (HP:0002006)1.32699139
74Vascular calcification (HP:0004934)1.31544925
75Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.31056042
76Easy fatigability (HP:0003388)1.30549800
77Exercise-induced myalgia (HP:0003738)1.30204170
78Heterotopia (HP:0002282)1.29251278
79Irregular epiphyses (HP:0010582)1.29029449
80Flattened epiphyses (HP:0003071)1.26899322
81Bell-shaped thorax (HP:0001591)1.26283214
82Oculomotor apraxia (HP:0000657)1.25452155
83Abnormality of the neuromuscular junction (HP:0003398)1.24365048
84Fatigable weakness (HP:0003473)1.24365048
85Vaginal atresia (HP:0000148)1.22283931
86Deformed sella turcica (HP:0002681)1.20754193
87Renal dysplasia (HP:0000110)1.20560514
88Genital tract atresia (HP:0001827)1.20518834
89Asymmetric septal hypertrophy (HP:0001670)1.19289442
90Epiphyseal dysplasia (HP:0002656)1.19235986
91Cardiovascular calcification (HP:0011915)1.18517024
92Short thorax (HP:0010306)1.17611960
93Decreased electroretinogram (ERG) amplitude (HP:0000654)1.15771447
94Sensory axonal neuropathy (HP:0003390)1.15182401
95Abnormal urine output (HP:0012590)1.14969443
96J-shaped sella turcica (HP:0002680)1.14036982
97Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.13174562
98Cerebellar dysplasia (HP:0007033)1.13039262
99Poor coordination (HP:0002370)1.12839316
100Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.10889346

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.39813776
2PDK38.39813776
3TESK16.00643174
4PDK25.64141395
5PRKD34.46284975
6ICK4.22066646
7STK392.26030796
8WNK42.15418316
9PTK2B2.10619652
10STK381.83868999
11PNCK1.55833858
12NEK21.51589009
13DYRK1B1.35559190
14PDK11.22907175
15IRAK11.03233588
16STK38L0.96694297
17STK30.83817066
18LMTK20.81850296
19PDPK10.76926024
20WNK10.73879107
21DYRK30.73297457
22TYRO30.72563114
23TESK20.71329737
24MAPK150.71314818
25PASK0.70986530
26RIPK40.69302247
27MAP2K60.63727473
28BRSK20.62268624
29CCNB10.60795867
30CHEK20.59193548
31PINK10.56497655
32TTK0.53866201
33IRAK20.49602004
34NTRK20.46928954
35MAP3K100.42376573
36PRKG20.39324608
37MUSK0.35264311
38CHEK10.33626519
39PAK10.33461337
40PRKCG0.33259930
41PLK40.32087769
42NEK60.31069315
43CAMK1G0.29568270
44RIPK10.29457735
45PKN10.27665585
46EEF2K0.27447026
47CAMKK10.25016796
48BRSK10.24939257
49ATM0.22847872
50WEE10.22610890
51PRKAA10.22144549
52PAK20.20842629
53MAPKAPK50.19617945
54MARK20.19488502
55MARK30.18883060
56PRKCQ0.18436409
57PRKCZ0.17450335
58RPS6KB10.17257516
59ATR0.16807207
60PLK10.15748346
61CDK150.15367282
62MTOR0.14770680
63MAP3K30.14571060
64PRKG10.13612627
65CDK120.13599959
66PAK40.13372811
67CDK11A0.13126111
68RPS6KA10.12912967
69PBK0.12888270
70CDK180.12506926
71STK110.12311916
72CDC70.11218028
73CDK140.10257409
74NME10.09667916
75PRKACG0.09061322
76DDR20.08091592
77CSNK2A10.06537877
78CSF1R0.05512121
79PRKCD0.05427082
80CSNK1D0.05293158
81YES10.03919382
82PIM10.03740156
83BRAF0.03674374
84PRKCA0.03429545
85CAMK2A0.03018595
86GSK3B0.02552818
87PRKCB0.01573578
88PRKACA0.01087490
89EGFR0.00823693
90IGF1R-0.0434668
91GSK3A-0.0350566
92WNK3-0.0320881
93PRKACB-0.0318617
94CDK4-0.0315503
95CDK1-0.0266190
96STK10-0.0244157
97CSNK2A2-0.0176601
98CDK2-0.0158332
99MAPK8-0.0144516
100LATS1-0.0021763

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.40480519
2Fatty acid biosynthesis_Homo sapiens_hsa000614.37234170
3Vitamin B6 metabolism_Homo sapiens_hsa007504.20227898
4Pyruvate metabolism_Homo sapiens_hsa006203.53824626
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.05326128
6Propanoate metabolism_Homo sapiens_hsa006402.94662866
7Linoleic acid metabolism_Homo sapiens_hsa005912.94449172
8Glucagon signaling pathway_Homo sapiens_hsa049222.54405287
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.49020427
10Basal transcription factors_Homo sapiens_hsa030222.47981891
11Selenocompound metabolism_Homo sapiens_hsa004502.23484124
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.23448745
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.16461651
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.07035921
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.98737756
16Glycerolipid metabolism_Homo sapiens_hsa005611.93384076
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.90310961
18Pentose phosphate pathway_Homo sapiens_hsa000301.87948780
19PPAR signaling pathway_Homo sapiens_hsa033201.83653486
20Oocyte meiosis_Homo sapiens_hsa041141.51280285
21Fructose and mannose metabolism_Homo sapiens_hsa000511.48315852
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.47357194
23Amphetamine addiction_Homo sapiens_hsa050311.46636747
24Fat digestion and absorption_Homo sapiens_hsa049751.43811843
25Cardiac muscle contraction_Homo sapiens_hsa042601.42755751
26Ether lipid metabolism_Homo sapiens_hsa005651.40486937
27Mineral absorption_Homo sapiens_hsa049781.36930461
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.31287596
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.28888472
30Carbon metabolism_Homo sapiens_hsa012001.24842621
31Fatty acid degradation_Homo sapiens_hsa000711.24092738
32Collecting duct acid secretion_Homo sapiens_hsa049661.22846417
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.22515878
34Huntingtons disease_Homo sapiens_hsa050161.20070590
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18622253
36Fatty acid metabolism_Homo sapiens_hsa012121.16681032
37Glutathione metabolism_Homo sapiens_hsa004801.16169678
38Dorso-ventral axis formation_Homo sapiens_hsa043201.13481569
39Fanconi anemia pathway_Homo sapiens_hsa034601.11553646
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10828535
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10067077
42Purine metabolism_Homo sapiens_hsa002301.09875166
43Renin secretion_Homo sapiens_hsa049241.09401821
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03246052
45Arachidonic acid metabolism_Homo sapiens_hsa005900.95103461
46Chemical carcinogenesis_Homo sapiens_hsa052040.93375914
47Antigen processing and presentation_Homo sapiens_hsa046120.82928847
48Protein digestion and absorption_Homo sapiens_hsa049740.81559268
49Insulin secretion_Homo sapiens_hsa049110.80560873
50Hedgehog signaling pathway_Homo sapiens_hsa043400.78031975
51Sulfur metabolism_Homo sapiens_hsa009200.77823384
52Thyroid hormone synthesis_Homo sapiens_hsa049180.70514296
53Biosynthesis of amino acids_Homo sapiens_hsa012300.69962380
54Bile secretion_Homo sapiens_hsa049760.69350641
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69180262
56Renin-angiotensin system_Homo sapiens_hsa046140.67721571
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64930699
58mRNA surveillance pathway_Homo sapiens_hsa030150.64268122
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60890680
60Pancreatic secretion_Homo sapiens_hsa049720.60622522
61Long-term potentiation_Homo sapiens_hsa047200.60369522
62Calcium signaling pathway_Homo sapiens_hsa040200.58122867
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.57579413
64Legionellosis_Homo sapiens_hsa051340.56194444
65ABC transporters_Homo sapiens_hsa020100.53371393
66RNA transport_Homo sapiens_hsa030130.50853425
67Metabolic pathways_Homo sapiens_hsa011000.49931146
68Estrogen signaling pathway_Homo sapiens_hsa049150.48956926
69Salivary secretion_Homo sapiens_hsa049700.47722031
70Synaptic vesicle cycle_Homo sapiens_hsa047210.47685176
71Systemic lupus erythematosus_Homo sapiens_hsa053220.43820954
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43156108
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.42143481
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40035810
75Taste transduction_Homo sapiens_hsa047420.39686120
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.39407096
77Gastric acid secretion_Homo sapiens_hsa049710.38779306
78Inositol phosphate metabolism_Homo sapiens_hsa005620.33089199
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32517742
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31839947
81AMPK signaling pathway_Homo sapiens_hsa041520.30805232
82Pyrimidine metabolism_Homo sapiens_hsa002400.30075968
83cAMP signaling pathway_Homo sapiens_hsa040240.29414637
84N-Glycan biosynthesis_Homo sapiens_hsa005100.28782973
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.26561396
86VEGF signaling pathway_Homo sapiens_hsa043700.24768949
87Vibrio cholerae infection_Homo sapiens_hsa051100.24711860
88Endocytosis_Homo sapiens_hsa041440.23749938
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.19540652
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18406011
91Circadian entrainment_Homo sapiens_hsa047130.18273242
92Cocaine addiction_Homo sapiens_hsa050300.14720021
93Sphingolipid metabolism_Homo sapiens_hsa006000.14708351
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.14608413
95Alcoholism_Homo sapiens_hsa050340.11304400
96Alzheimers disease_Homo sapiens_hsa050100.10044345
97Wnt signaling pathway_Homo sapiens_hsa043100.09709410
98Retinol metabolism_Homo sapiens_hsa008300.09244987
99HIF-1 signaling pathway_Homo sapiens_hsa040660.08639683
100Oxidative phosphorylation_Homo sapiens_hsa001900.07514098

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »