TXNDC9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the thioredoxin family. The exact function of this protein is not known but it is associated with cell differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.49552841
2protein neddylation (GO:0045116)4.93697345
3termination of RNA polymerase III transcription (GO:0006386)4.64013312
4transcription elongation from RNA polymerase III promoter (GO:0006385)4.64013312
5ribosomal large subunit biogenesis (GO:0042273)4.61002826
6ribosomal small subunit biogenesis (GO:0042274)4.54247345
77-methylguanosine mRNA capping (GO:0006370)4.48471899
8negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.43983411
97-methylguanosine RNA capping (GO:0009452)4.43770476
10RNA capping (GO:0036260)4.43770476
11establishment of integrated proviral latency (GO:0075713)4.42406117
12maturation of SSU-rRNA (GO:0030490)4.30472296
13positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.25790793
14viral transcription (GO:0019083)4.20863721
15ribosomal small subunit assembly (GO:0000028)4.18515231
16translational termination (GO:0006415)4.17347795
17regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.16657167
18anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.12247727
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.08816631
20negative regulation of ligase activity (GO:0051352)4.07729220
21negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.07729220
22transcription elongation from RNA polymerase I promoter (GO:0006362)3.99429089
23regulation of cellular amino acid metabolic process (GO:0006521)3.97279218
24chaperone-mediated protein transport (GO:0072321)3.95209690
25DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.95078347
26termination of RNA polymerase I transcription (GO:0006363)3.94132362
27establishment of protein localization to mitochondrial membrane (GO:0090151)3.87752841
28signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.87362297
29intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.87362297
30signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.86633645
31signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.86633645
32signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.86633645
33cotranslational protein targeting to membrane (GO:0006613)3.85246688
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.82039615
35histone exchange (GO:0043486)3.81152623
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.77327085
37energy coupled proton transport, down electrochemical gradient (GO:0015985)3.77266164
38ATP synthesis coupled proton transport (GO:0015986)3.77266164
39protein targeting to ER (GO:0045047)3.76730037
40cullin deneddylation (GO:0010388)3.75654124
41signal transduction involved in DNA integrity checkpoint (GO:0072401)3.75242069
42signal transduction involved in DNA damage checkpoint (GO:0072422)3.75242069
43ribonucleoprotein complex biogenesis (GO:0022613)3.74271952
44signal transduction involved in cell cycle checkpoint (GO:0072395)3.73979460
45positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.70629839
46DNA double-strand break processing (GO:0000729)3.67510843
47regulation of mitotic spindle checkpoint (GO:1903504)3.66791125
48regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.66791125
49maturation of 5.8S rRNA (GO:0000460)3.65521288
50protein deneddylation (GO:0000338)3.63469944
51transcription from RNA polymerase I promoter (GO:0006360)3.62796531
52protein localization to endoplasmic reticulum (GO:0070972)3.62739617
53positive regulation of ligase activity (GO:0051351)3.58282955
54establishment of protein localization to endoplasmic reticulum (GO:0072599)3.57373630
55antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.55077055
56translational initiation (GO:0006413)3.54804281
57translation (GO:0006412)3.54427799
58establishment of viral latency (GO:0019043)3.50715848
59translational elongation (GO:0006414)3.48613199
60protein localization to kinetochore (GO:0034501)3.48102425
61CENP-A containing nucleosome assembly (GO:0034080)3.46374247
62transcription-coupled nucleotide-excision repair (GO:0006283)3.44369561
63respiratory electron transport chain (GO:0022904)3.42547397
64respiratory chain complex IV assembly (GO:0008535)3.42335992
65mitotic metaphase plate congression (GO:0007080)3.41121487
66cellular protein complex disassembly (GO:0043624)3.39854405
67rRNA processing (GO:0006364)3.39205466
68transcription elongation from RNA polymerase II promoter (GO:0006368)3.37342379
69metaphase plate congression (GO:0051310)3.36192856
70histone mRNA metabolic process (GO:0008334)3.36066690
71viral life cycle (GO:0019058)3.35872928
72electron transport chain (GO:0022900)3.34736177
73DNA catabolic process, exonucleolytic (GO:0000738)3.34625545
74DNA replication-independent nucleosome assembly (GO:0006336)3.34618493
75DNA replication-independent nucleosome organization (GO:0034724)3.34618493
76rRNA modification (GO:0000154)3.33646977
77transcription initiation from RNA polymerase I promoter (GO:0006361)3.33330415
78spliceosomal snRNP assembly (GO:0000387)3.32142094
79GTP biosynthetic process (GO:0006183)3.29586034
80inner mitochondrial membrane organization (GO:0007007)3.27346776
81cellular component biogenesis (GO:0044085)3.26912607
82protein complex biogenesis (GO:0070271)3.26902083
83rRNA methylation (GO:0031167)3.26365961
84rRNA metabolic process (GO:0016072)3.26115342
85regulation of ubiquitin-protein transferase activity (GO:0051438)3.25649648
86DNA-templated transcription, elongation (GO:0006354)3.23957981
87mitochondrial respiratory chain complex assembly (GO:0033108)3.23646918
88chromatin remodeling at centromere (GO:0031055)3.23578681
89mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.23008858
90L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.21673214
91platelet dense granule organization (GO:0060155)3.20726775
92ribosome assembly (GO:0042255)3.20382008
93negative regulation of protein ubiquitination (GO:0031397)3.19716865
94DNA ligation (GO:0006266)3.18570270
95nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.17598185
96DNA replication checkpoint (GO:0000076)3.17366251
97regulation of ligase activity (GO:0051340)3.17288152
98tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.16767936
99RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.16767936
100spindle checkpoint (GO:0031577)3.16545256
101peptidyl-histidine modification (GO:0018202)3.15957461
102protein localization to mitochondrion (GO:0070585)3.12410440
103DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.10894064
104ribosome biogenesis (GO:0042254)3.10767791
105somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.10031187
106isotype switching (GO:0045190)3.10031187
107somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.10031187
108mitotic spindle checkpoint (GO:0071174)3.09030440
109DNA deamination (GO:0045006)3.08642966
110formation of translation preinitiation complex (GO:0001731)3.07986012
111IMP biosynthetic process (GO:0006188)3.07687167
112mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07184990
113mitochondrial respiratory chain complex I assembly (GO:0032981)3.07184990
114NADH dehydrogenase complex assembly (GO:0010257)3.07184990
115regulation of mitochondrial translation (GO:0070129)3.06837024
116positive regulation of cell cycle arrest (GO:0071158)3.06612845
117positive regulation of viral transcription (GO:0050434)3.06606661
118establishment of protein localization to mitochondrion (GO:0072655)3.04996693
119protein targeting to mitochondrion (GO:0006626)3.04763978
120pseudouridine synthesis (GO:0001522)3.04753527
121microtubule depolymerization (GO:0007019)2.99720421
122protein K11-linked ubiquitination (GO:0070979)2.97242492
123guanosine-containing compound biosynthetic process (GO:1901070)2.96707035
124double-strand break repair via nonhomologous end joining (GO:0006303)2.96499200
125non-recombinational repair (GO:0000726)2.96499200
126purine nucleobase biosynthetic process (GO:0009113)2.95926513
127negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.95873168
128nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.95464309
129DNA damage response, detection of DNA damage (GO:0042769)2.95203272
130kinetochore assembly (GO:0051382)2.93156085
131negative regulation of sister chromatid segregation (GO:0033046)2.92387602
132negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.92387602
133negative regulation of mitotic sister chromatid segregation (GO:0033048)2.92387602
134spliceosomal complex assembly (GO:0000245)2.92226757
135telomere maintenance via recombination (GO:0000722)2.90634205
136regulation of cellular amine metabolic process (GO:0033238)2.90248407
137kinetochore organization (GO:0051383)2.89711581
138G1/S transition of mitotic cell cycle (GO:0000082)2.88533104
139cell cycle G1/S phase transition (GO:0044843)2.88533104
140antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.88067543
141exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84125123
142telomere maintenance via semi-conservative replication (GO:0032201)2.83774504

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.00956952
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.68511669
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.28680484
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.74060326
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.74009756
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.73890308
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.56408655
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.56233922
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.44648964
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.37547274
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.27180568
12E2F7_22180533_ChIP-Seq_HELA_Human3.26460688
13* CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.10270913
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.05235039
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.72938899
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70174066
17ELK1_19687146_ChIP-ChIP_HELA_Human2.69335627
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.68927286
19VDR_23849224_ChIP-Seq_CD4+_Human2.68132387
20* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.52777050
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45351021
22DCP1A_22483619_ChIP-Seq_HELA_Human2.43404009
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.39320627
24* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38625403
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.34014786
26* SRF_21415370_ChIP-Seq_HL-1_Mouse2.19858105
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13958259
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13403094
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.11010895
30* FOXP3_21729870_ChIP-Seq_TREG_Human2.04841673
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.00320716
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.98941842
33TTF2_22483619_ChIP-Seq_HELA_Human1.97214945
34* XRN2_22483619_ChIP-Seq_HELA_Human1.97196413
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92553852
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86054605
37GABP_19822575_ChIP-Seq_HepG2_Human1.83195240
38* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.82570034
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80221384
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79542488
41ELK1_22589737_ChIP-Seq_MCF10A_Human1.77192148
42AR_21909140_ChIP-Seq_LNCAP_Human1.75397534
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.73808015
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73423618
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.70100028
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66380145
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57964014
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56531785
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51918130
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47078261
51ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.43812354
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42286820
53ZNF274_21170338_ChIP-Seq_K562_Hela1.40407289
54* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40090063
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37950921
56TAF15_26573619_Chip-Seq_HEK293_Human1.37222198
57HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.34783496
58MYC_18940864_ChIP-ChIP_HL60_Human1.33447337
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25770206
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21380030
61BP1_19119308_ChIP-ChIP_Hs578T_Human1.20663680
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16195175
63P300_19829295_ChIP-Seq_ESCs_Human1.15937156
64* FLI1_27457419_Chip-Seq_LIVER_Mouse1.15842198
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15441979
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15414018
67* SOX17_20123909_ChIP-Seq_XEN_Mouse1.13001931
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.12970576
69* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11307247
70IGF1R_20145208_ChIP-Seq_DFB_Human1.11207643
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.10889417
72CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09568849
73SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08933124
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08467731
75* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08181116
76* EZH2_27294783_Chip-Seq_NPCs_Mouse1.07936557
77* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03847921
78VDR_22108803_ChIP-Seq_LS180_Human1.02389513
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02249586
80IRF1_19129219_ChIP-ChIP_H3396_Human1.00567911
81FUS_26573619_Chip-Seq_HEK293_Human0.99524292
82* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.96585082
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96555488
84PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94406260
85KDM5A_27292631_Chip-Seq_BREAST_Human0.94180698
86IRF8_21731497_ChIP-ChIP_J774_Mouse0.94150129
87IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.93578021
88TP63_19390658_ChIP-ChIP_HaCaT_Human0.92923889
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92178531
90ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92171909
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92018870
92EWS_26573619_Chip-Seq_HEK293_Human0.90098503
93SOX2_19829295_ChIP-Seq_ESCs_Human0.88101740
94NANOG_19829295_ChIP-Seq_ESCs_Human0.88101740
95SALL4_22934838_ChIP-ChIP_CD34+_Human0.88018677
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86352685
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85025133
98E2F1_21310950_ChIP-Seq_MCF-7_Human0.84781792
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83133889
100* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82928162
101POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82881597
102ZFP57_27257070_Chip-Seq_ESCs_Mouse0.81577200
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80634914
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.79805037
105EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.79789203
106* CRX_20693478_ChIP-Seq_RETINA_Mouse0.79373381
107TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78461578
108SPI1_23547873_ChIP-Seq_NB4_Human0.77511897
109TP53_22573176_ChIP-Seq_HFKS_Human0.77370932
110TFEB_21752829_ChIP-Seq_HELA_Human0.76822104
111SALL1_21062744_ChIP-ChIP_HESCs_Human0.76138981
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.74177186
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.73846281
114FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72965501
115TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.72327985
116ELF5_23300383_ChIP-Seq_T47D_Human0.69591319
117NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.69429627
118ER_23166858_ChIP-Seq_MCF-7_Human0.69031224
119* NFE2_27457419_Chip-Seq_LIVER_Mouse0.68838476
120SOX2_18555785_ChIP-Seq_MESCs_Mouse0.67645263
121* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.66434302

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.58066266
2MP0009379_abnormal_foot_pigmentation3.61710387
3MP0004957_abnormal_blastocyst_morpholog3.50396798
4MP0003718_maternal_effect3.45814035
5MP0008932_abnormal_embryonic_tissue3.10203067
6MP0010094_abnormal_chromosome_stability3.06885284
7MP0008058_abnormal_DNA_repair2.98768705
8MP0003077_abnormal_cell_cycle2.77750050
9MP0008057_abnormal_DNA_replication2.68958622
10MP0003111_abnormal_nucleus_morphology2.64378547
11MP0003786_premature_aging2.57222883
12MP0006072_abnormal_retinal_apoptosis2.38539404
13MP0008007_abnormal_cellular_replicative2.28439642
14MP0001529_abnormal_vocalization2.23114870
15MP0008877_abnormal_DNA_methylation2.18942636
16MP0002102_abnormal_ear_morphology2.18199793
17MP0009697_abnormal_copulation2.16998109
18MP0003941_abnormal_skin_development2.16258724
19MP0003890_abnormal_embryonic-extraembry1.97618214
20MP0006054_spinal_hemorrhage1.95389484
21MP0001905_abnormal_dopamine_level1.94299403
22MP0003136_yellow_coat_color1.91929849
23MP0008260_abnormal_autophagy1.88286890
24MP0006292_abnormal_olfactory_placode1.87264720
25MP0001188_hyperpigmentation1.85296752
26MP0005084_abnormal_gallbladder_morpholo1.84295869
27MP0004147_increased_porphyrin_level1.79840468
28MP0000566_synostosis1.72995253
29MP0005075_abnormal_melanosome_morpholog1.71878148
30MP0009333_abnormal_splenocyte_physiolog1.70262868
31MP0002938_white_spotting1.68070996
32MP0001293_anophthalmia1.62790213
33MP0001542_abnormal_bone_strength1.62686431
34MP0005171_absent_coat_pigmentation1.61440505
35MP0003123_paternal_imprinting1.59180802
36MP0002163_abnormal_gland_morphology1.56240829
37MP0003315_abnormal_perineum_morphology1.56053596
38MP0003186_abnormal_redox_activity1.55900638
39MP0005408_hypopigmentation1.51863625
40MP0000372_irregular_coat_pigmentation1.50246316
41MP0008789_abnormal_olfactory_epithelium1.45232201
42MP0005451_abnormal_body_composition1.36530500
43MP0002837_dystrophic_cardiac_calcinosis1.35239044
44MP0002210_abnormal_sex_determination1.31586751
45MP0002148_abnormal_hypersensitivity_rea1.27552067
46MP0002254_reproductive_system_inflammat1.25766601
47MP0001727_abnormal_embryo_implantation1.24595369
48MP0001986_abnormal_taste_sensitivity1.20750141
49MP0003195_calcinosis1.20019269
50MP0002234_abnormal_pharynx_morphology1.19692123
51MP0002090_abnormal_vision1.17301953
52MP0004215_abnormal_myocardial_fiber1.15547095
53MP0005253_abnormal_eye_physiology1.15429956
54MP0008875_abnormal_xenobiotic_pharmacok1.15298284
55MP0002277_abnormal_respiratory_mucosa1.15060701
56MP0003121_genomic_imprinting1.13528205
57MP0003937_abnormal_limbs/digits/tail_de1.12833791
58MP0009785_altered_susceptibility_to1.12706963
59MP0001730_embryonic_growth_arrest1.12439157
60MP0000350_abnormal_cell_proliferation1.11909986
61MP0001764_abnormal_homeostasis1.10670987
62MP0005389_reproductive_system_phenotype1.10323750
63MP0005395_other_phenotype1.09747860
64MP0006276_abnormal_autonomic_nervous1.09548872
65MP0003938_abnormal_ear_development1.09364397
66MP0003880_abnormal_central_pattern1.08824566
67MP0003950_abnormal_plasma_membrane1.07077923
68MP0003252_abnormal_bile_duct1.06561149
69MP0001346_abnormal_lacrimal_gland1.06147792
70MP0001929_abnormal_gametogenesis1.05779475
71MP0002751_abnormal_autonomic_nervous1.04415605
72MP0004381_abnormal_hair_follicle1.04150894
73MP0000015_abnormal_ear_pigmentation1.03257484
74MP0002160_abnormal_reproductive_system1.01671602
75MP0010030_abnormal_orbit_morphology1.00233245
76MP0003567_abnormal_fetal_cardiomyocyte0.99391840
77MP0003011_delayed_dark_adaptation0.98935184
78MP0001145_abnormal_male_reproductive0.98833209
79MP0005671_abnormal_response_to0.98624249
80MP0002638_abnormal_pupillary_reflex0.97855704
81MP0002084_abnormal_developmental_patter0.97790678
82MP0000313_abnormal_cell_death0.96806700
83MP0001919_abnormal_reproductive_system0.96345068
84MP0000653_abnormal_sex_gland0.94969266
85MP0001119_abnormal_female_reproductive0.93229553
86MP0000516_abnormal_urinary_system0.92592782
87MP0005367_renal/urinary_system_phenotyp0.92592782
88MP0001853_heart_inflammation0.90438602
89MP0003806_abnormal_nucleotide_metabolis0.90124031
90MP0005085_abnormal_gallbladder_physiolo0.90001302
91MP0006035_abnormal_mitochondrial_morpho0.89928944
92MP0001835_abnormal_antigen_presentation0.89711599
93MP0010307_abnormal_tumor_latency0.89320671
94MP0000049_abnormal_middle_ear0.89068401
95MP0002095_abnormal_skin_pigmentation0.88542405
96MP0002132_abnormal_respiratory_system0.88295852
97MP0004133_heterotaxia0.87288718
98MP0005332_abnormal_amino_acid0.87269057
99MP0002233_abnormal_nose_morphology0.87076048
100MP0002282_abnormal_trachea_morphology0.86931949
101MP0002177_abnormal_outer_ear0.83599920
102MP0008995_early_reproductive_senescence0.82216119
103MP0001697_abnormal_embryo_size0.81155996
104MP0009250_abnormal_appendicular_skeleto0.80126342
105MP0005551_abnormal_eye_electrophysiolog0.79796457
106MP0005379_endocrine/exocrine_gland_phen0.78797277
107MP0000647_abnormal_sebaceous_gland0.77827816
108MP0000427_abnormal_hair_cycle0.75768864
109MP0003724_increased_susceptibility_to0.75135398
110MP0006036_abnormal_mitochondrial_physio0.73932186
111MP0003755_abnormal_palate_morphology0.72784034
112MP0000749_muscle_degeneration0.71442968
113MP0002019_abnormal_tumor_incidence0.70957519
114MP0005000_abnormal_immune_tolerance0.70950620
115MP0000627_abnormal_mammary_gland0.70071608
116MP0004134_abnormal_chest_morphology0.69369665
117MP0003119_abnormal_digestive_system0.68721412
118MP0003984_embryonic_growth_retardation0.68670401
119MP0002088_abnormal_embryonic_growth/wei0.67963192
120MP0003936_abnormal_reproductive_system0.67693431
121MP0002006_tumorigenesis0.67245487
122MP0000358_abnormal_cell_content/0.66453874
123MP0005410_abnormal_fertilization0.65701041
124MP0010368_abnormal_lymphatic_system0.64923858
125MP0004142_abnormal_muscle_tone0.64010988
126MP0008872_abnormal_physiological_respon0.63660263
127MP0005391_vision/eye_phenotype0.63527814
128MP0000490_abnormal_crypts_of0.63351095
129MP0003221_abnormal_cardiomyocyte_apopto0.62483068
130MP0000762_abnormal_tongue_morphology0.62200005
131MP0005394_taste/olfaction_phenotype0.61777796
132MP0005499_abnormal_olfactory_system0.61777796
133MP0002080_prenatal_lethality0.61718149
134MP0001485_abnormal_pinna_reflex0.61533021
135MP0001243_abnormal_dermal_layer0.61414328
136MP0005645_abnormal_hypothalamus_physiol0.61182735
137MP0001286_abnormal_eye_development0.59952172
138MP0002396_abnormal_hematopoietic_system0.59200537
139MP0002452_abnormal_antigen_presenting0.57421223
140MP0005380_embryogenesis_phenotype0.57153119
141MP0001672_abnormal_embryogenesis/_devel0.57153119
142MP0003698_abnormal_male_reproductive0.56785134
143MP0005409_darkened_coat_color0.55599169
144MP0010386_abnormal_urinary_bladder0.54775355
145MP0002420_abnormal_adaptive_immunity0.54583264
146MP0002085_abnormal_embryonic_tissue0.54468013

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)4.10809651
2Mitochondrial inheritance (HP:0001427)3.91407026
3Acute necrotizing encephalopathy (HP:0006965)3.87032391
43-Methylglutaconic aciduria (HP:0003535)3.69207536
5Reticulocytopenia (HP:0001896)3.59407485
6Birth length less than 3rd percentile (HP:0003561)3.55512583
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.50748159
8Renal Fanconi syndrome (HP:0001994)3.44935108
9Lipid accumulation in hepatocytes (HP:0006561)3.38402813
10Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.35084967
11Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.34526176
12Increased CSF lactate (HP:0002490)3.32674603
13Abnormal mitochondria in muscle tissue (HP:0008316)3.24302569
14Abnormality of the labia minora (HP:0012880)3.21422234
15Hepatocellular necrosis (HP:0001404)3.20867756
16Exertional dyspnea (HP:0002875)3.18047590
17Abnormality of methionine metabolism (HP:0010901)3.17479806
18Progressive macrocephaly (HP:0004481)3.16724950
19Increased serum pyruvate (HP:0003542)3.13849059
20Abnormality of glycolysis (HP:0004366)3.13849059
21Cerebral edema (HP:0002181)3.13233814
22Abnormality of cells of the erythroid lineage (HP:0012130)3.08416788
23Breast hypoplasia (HP:0003187)3.06246913
24Methylmalonic acidemia (HP:0002912)3.04139290
25Acute encephalopathy (HP:0006846)2.88360892
26Parakeratosis (HP:0001036)2.86969800
27Cerebral hypomyelination (HP:0006808)2.86350960
28Abnormality of aspartate family amino acid metabolism (HP:0010899)2.84579619
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.82757236
30Macrocytic anemia (HP:0001972)2.77362726
31Congenital, generalized hypertrichosis (HP:0004540)2.72338835
32Abnormality of placental membranes (HP:0011409)2.63629087
33Amniotic constriction ring (HP:0009775)2.63629087
34Respiratory difficulties (HP:0002880)2.63353161
35Abnormal number of erythroid precursors (HP:0012131)2.61788276
36Abnormal protein N-linked glycosylation (HP:0012347)2.59712999
37Abnormal protein glycosylation (HP:0012346)2.59712999
38Abnormal glycosylation (HP:0012345)2.59712999
39Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.59712999
40Hepatic necrosis (HP:0002605)2.59689969
41Increased serum lactate (HP:0002151)2.58788266
42Absent radius (HP:0003974)2.55682896
43Secondary amenorrhea (HP:0000869)2.49017277
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.47147243
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.47147243
46Abnormality of the preputium (HP:0100587)2.47124768
47Rough bone trabeculation (HP:0100670)2.43860535
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.42302771
49Absent forearm bone (HP:0003953)2.41997085
50Aplasia involving forearm bones (HP:0009822)2.41997085
51Methylmalonic aciduria (HP:0012120)2.40680404
52Adrenal hypoplasia (HP:0000835)2.40673702
53Chromsome breakage (HP:0040012)2.39597469
54Reduced antithrombin III activity (HP:0001976)2.38138735
55Abnormality of the anterior horn cell (HP:0006802)2.37298913
56Degeneration of anterior horn cells (HP:0002398)2.37298913
57Exercise intolerance (HP:0003546)2.37091251
58Carpal bone hypoplasia (HP:0001498)2.34358676
59Triphalangeal thumb (HP:0001199)2.33661367
60Lethargy (HP:0001254)2.33585598
61Abnormality of serum amino acid levels (HP:0003112)2.33277169
62Meckel diverticulum (HP:0002245)2.32351193
63Congenital ichthyosiform erythroderma (HP:0007431)2.31444245
64Colon cancer (HP:0003003)2.30189701
65Pallor (HP:0000980)2.25198162
66Abnormality of the ileum (HP:0001549)2.24082133
67Patellar aplasia (HP:0006443)2.23218802
68Increased intramyocellular lipid droplets (HP:0012240)2.22082459
69Irregular epiphyses (HP:0010582)2.21358698
70Abnormality of renal resorption (HP:0011038)2.17467339
71Neoplasm of the adrenal gland (HP:0100631)2.17426093
72Palpitations (HP:0001962)2.16272345
73Duodenal stenosis (HP:0100867)2.16048615
74Small intestinal stenosis (HP:0012848)2.16048615
75Respiratory failure (HP:0002878)2.14971680
76Stenosis of the external auditory canal (HP:0000402)2.10333686
77Abnormal trabecular bone morphology (HP:0100671)2.09291915
78Hyperglycinemia (HP:0002154)2.09195878
79Aplasia/Hypoplasia of the patella (HP:0006498)2.08790695
80Bifid tongue (HP:0010297)2.07935556
81Megaloblastic anemia (HP:0001889)2.07659864
82Abnormality of midbrain morphology (HP:0002418)2.07462863
83Molar tooth sign on MRI (HP:0002419)2.07462863
84Aplasia/Hypoplasia involving the musculature (HP:0001460)2.06499603
85Pancreatic fibrosis (HP:0100732)2.05039703
86Supernumerary spleens (HP:0009799)2.02871363
87Medial flaring of the eyebrow (HP:0010747)2.00816228
88Trismus (HP:0000211)1.99969987
89Type 2 muscle fiber atrophy (HP:0003554)1.98499985
90Aplastic anemia (HP:0001915)1.97913797
91Hypothermia (HP:0002045)1.97840876
92Sensory axonal neuropathy (HP:0003390)1.96472104
93Lactic acidosis (HP:0003128)1.96067497
94Abnormal hemoglobin (HP:0011902)1.95814591
95Abnormality of alanine metabolism (HP:0010916)1.95385479
96Hyperalaninemia (HP:0003348)1.95385479
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95385479
98Cleft eyelid (HP:0000625)1.94450484
99Volvulus (HP:0002580)1.94268021
100Abnormality of vitamin B metabolism (HP:0004340)1.92718666
101Type I transferrin isoform profile (HP:0003642)1.92621406
102Pancreatic cysts (HP:0001737)1.90939089
103Abnormality of chromosome stability (HP:0003220)1.90681468
104Abnormality of the duodenum (HP:0002246)1.90458667
105CNS demyelination (HP:0007305)1.90227102
106Absent thumb (HP:0009777)1.87720177
107Abnormalities of placenta or umbilical cord (HP:0001194)1.87426624
108Short tibia (HP:0005736)1.86932586
109Pancytopenia (HP:0001876)1.86866801
110Aplasia/Hypoplasia of the uvula (HP:0010293)1.86336366
111Conjunctival hamartoma (HP:0100780)1.85671681
112Premature ovarian failure (HP:0008209)1.85666949
113Abnormality of the fovea (HP:0000493)1.85538762
114Abnormality of the vitamin B12 metabolism (HP:0004341)1.83779886
115Leukodystrophy (HP:0002415)1.83678065
116Entropion (HP:0000621)1.83090502
117Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.82989053
118Sparse eyelashes (HP:0000653)1.82921788
119Oral leukoplakia (HP:0002745)1.82306532
120True hermaphroditism (HP:0010459)1.81860607
121Horseshoe kidney (HP:0000085)1.81393446
122Optic disc pallor (HP:0000543)1.81149854
123Glycosuria (HP:0003076)1.80996289
124Abnormality of urine glucose concentration (HP:0011016)1.80996289
125Aplasia/Hypoplasia of the fovea (HP:0008060)1.80505624
126Hypoplasia of the fovea (HP:0007750)1.80505624
127Fibular aplasia (HP:0002990)1.78658460
128Abnormality of incisor morphology (HP:0011063)1.78428439
129Microvesicular hepatic steatosis (HP:0001414)1.77577219
130Abnormality of the umbilical cord (HP:0010881)1.77230100
131Duplicated collecting system (HP:0000081)1.76535412
132Abnormal lung lobation (HP:0002101)1.76357238
133Abnormality of the pons (HP:0007361)1.76123749
134Neuroendocrine neoplasm (HP:0100634)1.75772987
135Posterior subcapsular cataract (HP:0007787)1.75453954
136Rhabdomyosarcoma (HP:0002859)1.74981007
137Premature graying of hair (HP:0002216)1.74958963
138CNS hypomyelination (HP:0003429)1.74795727
139Nasolacrimal duct obstruction (HP:0000579)1.72824456
140Preaxial hand polydactyly (HP:0001177)1.71595391
141Abnormal umbilical cord blood vessels (HP:0011403)1.71488148
142Single umbilical artery (HP:0001195)1.71488148
143Abnormality of the fetal cardiovascular system (HP:0010948)1.71488148
144Aplasia/Hypoplasia of the tibia (HP:0005772)1.69294369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.86823309
2EIF2AK14.18786772
3STK163.68656907
4WEE12.86237849
5VRK22.80801038
6PBK2.72032596
7NME22.67558963
8EIF2AK32.63855200
9SRPK12.58142998
10MST42.55083489
11NEK12.54677243
12TRIM282.46808852
13PLK42.33531213
14VRK12.10264438
15MAP4K22.07039347
16PIM21.89483140
17MKNK11.77589841
18BRSK21.74376653
19NME11.68477864
20BMPR1B1.66995227
21ACVR1B1.54974857
22TESK21.54144760
23TLK11.50857724
24WNK31.50068746
25EIF2AK21.48988847
26BCR1.46353343
27ERBB31.43081494
28MKNK21.40160938
29MAP3K121.38656417
30BRAF1.37347835
31ZAK1.36957972
32PLK31.34623619
33DYRK21.31637824
34LIMK11.30018407
35NUAK11.26029352
36ARAF1.23502144
37PLK11.23023327
38EPHA21.21698654
39DYRK31.12692034
40CDK81.11959016
41FRK1.11682279
42IRAK31.09608286
43TSSK61.08488000
44CASK1.06357803
45TTK1.04166156
46IRAK41.02065119
47AURKB0.98544538
48PDK20.98024825
49GRK70.97862315
50PAK40.92924992
51AURKA0.90768623
52CCNB10.89488372
53GRK10.88272806
54YES10.87741781
55RPS6KA50.86326755
56AKT30.85987213
57STK390.82870940
58CSNK1G20.78024337
59TAF10.78009713
60PNCK0.76572425
61MAPKAPK50.75104434
62NEK90.74899311
63TXK0.74397655
64DAPK10.74094199
65PLK20.72646745
66CHEK20.72268993
67MAP2K70.68578213
68OXSR10.68034380
69BRSK10.67875270
70NEK60.66748258
71ABL20.66486890
72TESK10.65877814
73MUSK0.65372680
74CSNK2A10.63505376
75ADRBK20.63059010
76CDK70.62025606
77CDC70.61905312
78MELK0.61900405
79CSNK1G30.61021489
80TIE10.60704715
81SIK30.58897386
82RPS6KB20.58616774
83BLK0.58351788
84TNIK0.58181644
85STK40.57883463
86RPS6KA40.57868898
87STK38L0.57058883
88BMPR20.56448777
89NLK0.56263835
90ERBB40.56060080
91MAPK130.53736582
92STK100.52361533
93MYLK0.50726056
94BCKDK0.50589345
95PAK10.47930767
96ATM0.47404197
97CSNK2A20.47205573
98TAOK20.47092093
99TEC0.47073462
100NEK20.46608676
101ATR0.45286056
102PRKCE0.44859689
103CDK30.43508402
104MAP3K40.43408938
105ILK0.43339748
106PASK0.43292300
107IKBKB0.43051667
108MAPKAPK30.41590472
109PRKCI0.41108648
110FER0.40291437
111MST1R0.40255431
112STK240.39977187
113IRAK10.39953992
114MAP3K140.38392475
115KDR0.38163968
116CSNK1G10.38062626
117TGFBR10.37341133
118ADRBK10.37147540
119MAP3K30.37006487
120CHEK10.36306291
121STK30.36118926
122CDK190.35747407
123MAP3K80.35583096
124CSNK1A1L0.33931198
125ALK0.31780882
126MINK10.31315789
127SCYL20.30419034
128INSRR0.29030081
129FGFR10.28152797
130MATK0.21469186

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.00565082
2Ribosome_Homo sapiens_hsa030104.37290113
3RNA polymerase_Homo sapiens_hsa030204.29318400
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.13765534
5Oxidative phosphorylation_Homo sapiens_hsa001903.09042790
6Protein export_Homo sapiens_hsa030602.76172469
7Parkinsons disease_Homo sapiens_hsa050122.57054043
8Homologous recombination_Homo sapiens_hsa034402.50697459
9Basal transcription factors_Homo sapiens_hsa030222.49044374
10Spliceosome_Homo sapiens_hsa030402.45696291
11DNA replication_Homo sapiens_hsa030302.44578710
12Mismatch repair_Homo sapiens_hsa034302.41282663
13Pyrimidine metabolism_Homo sapiens_hsa002402.38551391
14Nucleotide excision repair_Homo sapiens_hsa034202.35719211
15RNA transport_Homo sapiens_hsa030132.13505703
16Huntingtons disease_Homo sapiens_hsa050162.06524632
17Propanoate metabolism_Homo sapiens_hsa006401.90971379
18Fanconi anemia pathway_Homo sapiens_hsa034601.87733162
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82617949
20Non-homologous end-joining_Homo sapiens_hsa034501.71182874
21Vitamin B6 metabolism_Homo sapiens_hsa007501.68973330
22Alzheimers disease_Homo sapiens_hsa050101.68020810
23Base excision repair_Homo sapiens_hsa034101.64625171
24Cell cycle_Homo sapiens_hsa041101.60929853
25RNA degradation_Homo sapiens_hsa030181.48563218
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.47755664
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43943376
28Purine metabolism_Homo sapiens_hsa002301.43810321
29Pyruvate metabolism_Homo sapiens_hsa006201.41838093
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41459844
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27555726
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25297423
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22591167
34p53 signaling pathway_Homo sapiens_hsa041151.22236070
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20208085
36Epstein-Barr virus infection_Homo sapiens_hsa051691.19717965
37Graft-versus-host disease_Homo sapiens_hsa053321.14578876
38Sulfur metabolism_Homo sapiens_hsa009201.14431465
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06759063
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05767639
41Regulation of autophagy_Homo sapiens_hsa041400.96993956
42Rheumatoid arthritis_Homo sapiens_hsa053230.92710683
43Collecting duct acid secretion_Homo sapiens_hsa049660.92613276
44Allograft rejection_Homo sapiens_hsa053300.92072642
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90090176
46mRNA surveillance pathway_Homo sapiens_hsa030150.87355729
47Butanoate metabolism_Homo sapiens_hsa006500.86394076
48Selenocompound metabolism_Homo sapiens_hsa004500.82674420
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80507691
50Peroxisome_Homo sapiens_hsa041460.80292318
51Arachidonic acid metabolism_Homo sapiens_hsa005900.80028391
52Sphingolipid metabolism_Homo sapiens_hsa006000.79829818
53Steroid biosynthesis_Homo sapiens_hsa001000.75488760
54Caffeine metabolism_Homo sapiens_hsa002320.75356105
55Glutathione metabolism_Homo sapiens_hsa004800.74993553
56Autoimmune thyroid disease_Homo sapiens_hsa053200.74531362
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73214867
58Systemic lupus erythematosus_Homo sapiens_hsa053220.70325480
59One carbon pool by folate_Homo sapiens_hsa006700.68986646
60Carbon metabolism_Homo sapiens_hsa012000.67846915
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67468656
62Folate biosynthesis_Homo sapiens_hsa007900.66916635
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65377893
64Phagosome_Homo sapiens_hsa041450.63845732
65Vibrio cholerae infection_Homo sapiens_hsa051100.62077540
66Ether lipid metabolism_Homo sapiens_hsa005650.61729234
67Hematopoietic cell lineage_Homo sapiens_hsa046400.59905720
68Asthma_Homo sapiens_hsa053100.59124046
69N-Glycan biosynthesis_Homo sapiens_hsa005100.58192764
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57724464
71Cardiac muscle contraction_Homo sapiens_hsa042600.57613409
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57530337
73Tryptophan metabolism_Homo sapiens_hsa003800.53716762
74Chemical carcinogenesis_Homo sapiens_hsa052040.53364809
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.53139218
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52732932
77Metabolic pathways_Homo sapiens_hsa011000.52488958
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51574468
79Primary immunodeficiency_Homo sapiens_hsa053400.50775894
80Herpes simplex infection_Homo sapiens_hsa051680.50392338
81Antigen processing and presentation_Homo sapiens_hsa046120.49234688
82Fatty acid degradation_Homo sapiens_hsa000710.48733592
83Pentose phosphate pathway_Homo sapiens_hsa000300.48591444
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47806409
85Fatty acid metabolism_Homo sapiens_hsa012120.47483407
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.47483162
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47321779
88Linoleic acid metabolism_Homo sapiens_hsa005910.46183493
89Fatty acid elongation_Homo sapiens_hsa000620.43690785
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43394086
91Type I diabetes mellitus_Homo sapiens_hsa049400.43106153
92Malaria_Homo sapiens_hsa051440.42780929
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42275431
94Oocyte meiosis_Homo sapiens_hsa041140.41511393
95Retinol metabolism_Homo sapiens_hsa008300.41367419
96Legionellosis_Homo sapiens_hsa051340.40762227
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37259673
98Viral carcinogenesis_Homo sapiens_hsa052030.37055130
99Biosynthesis of amino acids_Homo sapiens_hsa012300.36854144
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36758750
101beta-Alanine metabolism_Homo sapiens_hsa004100.36082659
102Measles_Homo sapiens_hsa051620.34632197
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33615156
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32054589
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.31991769
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31865244
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31834773
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30220686
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30110084
110Other glycan degradation_Homo sapiens_hsa005110.30041874
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.27482075
112TGF-beta signaling pathway_Homo sapiens_hsa043500.27375659
113Apoptosis_Homo sapiens_hsa042100.26247341
114Shigellosis_Homo sapiens_hsa051310.24661821
115Vitamin digestion and absorption_Homo sapiens_hsa049770.24539898
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23201343
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23007750
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.22499711
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19596080
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17054523
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.16893969
122Phototransduction_Homo sapiens_hsa047440.16792932
123Alcoholism_Homo sapiens_hsa050340.16420591
124Cysteine and methionine metabolism_Homo sapiens_hsa002700.16342723
125Sulfur relay system_Homo sapiens_hsa041220.15841972
126HTLV-I infection_Homo sapiens_hsa051660.14316159
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.11894169
128Mineral absorption_Homo sapiens_hsa049780.10884759
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.10614368
130Tyrosine metabolism_Homo sapiens_hsa003500.10351482
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.09755559
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.09232651
133Influenza A_Homo sapiens_hsa051640.09040606
134Arginine and proline metabolism_Homo sapiens_hsa003300.08934747
135Nitrogen metabolism_Homo sapiens_hsa009100.07513220
136Salmonella infection_Homo sapiens_hsa051320.07383207
137Renin-angiotensin system_Homo sapiens_hsa046140.06386877
138Fructose and mannose metabolism_Homo sapiens_hsa000510.05709249

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