TXNIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.07098612
2negative regulation of cell killing (GO:0031342)7.07098612
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.38260956
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.38260956
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.27203087
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.27203087
7modulation by symbiont of host immune response (GO:0052553)5.27203087
8positive regulation by symbiont of host defense response (GO:0052509)5.27203087
9modulation by symbiont of host defense response (GO:0052031)5.27203087
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.27203087
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.15973919
12detection of other organism (GO:0098543)4.81958401
13antigen processing and presentation of endogenous antigen (GO:0019883)4.73870579
14response to interleukin-15 (GO:0070672)4.58511997
15detection of bacterium (GO:0016045)4.57146825
16negative regulation of lymphocyte mediated immunity (GO:0002707)4.48739714
17macrophage activation involved in immune response (GO:0002281)4.38737779
18neutrophil activation involved in immune response (GO:0002283)4.34714425
19leukocyte aggregation (GO:0070486)4.34489785
20valine metabolic process (GO:0006573)4.32621103
21cellular extravasation (GO:0045123)4.27275187
22negative T cell selection (GO:0043383)4.23530713
23cellular response to interleukin-15 (GO:0071350)4.23311460
24negative thymic T cell selection (GO:0045060)4.22747311
25detection of external biotic stimulus (GO:0098581)4.18914374
26detection of molecule of bacterial origin (GO:0032490)4.09336923
27negative regulation of T cell mediated immunity (GO:0002710)4.07423263
28negative regulation of erythrocyte differentiation (GO:0045647)4.05111421
29positive regulation of gamma-delta T cell activation (GO:0046645)3.95449204
30antigen processing and presentation via MHC class Ib (GO:0002475)3.92618738
31negative regulation of leukocyte mediated immunity (GO:0002704)3.91872443
32regulation of sequestering of triglyceride (GO:0010889)3.82978461
33regulation of gamma-delta T cell differentiation (GO:0045586)3.78567396
34definitive hemopoiesis (GO:0060216)3.77630495
35neutrophil activation (GO:0042119)3.77557393
36microglial cell activation (GO:0001774)3.77467473
37B cell receptor signaling pathway (GO:0050853)3.76898894
38low-density lipoprotein particle clearance (GO:0034383)3.71155498
39response to peptidoglycan (GO:0032494)3.69383792
40fatty acid transmembrane transport (GO:1902001)3.68975597
41positive T cell selection (GO:0043368)3.67489063
42activated T cell proliferation (GO:0050798)3.66570817
43negative regulation of interleukin-12 production (GO:0032695)3.63923986
44response to host immune response (GO:0052572)3.63667257
45response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.63667257
46carnitine shuttle (GO:0006853)3.63435118
47detection of biotic stimulus (GO:0009595)3.63235758
48positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.60596546
49negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.55349196
50negative regulation of granulocyte differentiation (GO:0030853)3.55296059
51T cell selection (GO:0045058)3.54468746
52respiratory burst (GO:0045730)3.53552378
53regulation of T cell tolerance induction (GO:0002664)3.50764499
54regulation of cholesterol storage (GO:0010885)3.45407228
55regulation of tolerance induction (GO:0002643)3.44395633
56positive regulation of histone deacetylation (GO:0031065)3.41895242
57T cell migration (GO:0072678)3.41420678
58response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.40492245
59response to host (GO:0075136)3.40492245
60response to host defenses (GO:0052200)3.40492245
61regulation of gamma-delta T cell activation (GO:0046643)3.36793211
62neutrophil mediated immunity (GO:0002446)3.36063426
63immunoglobulin mediated immune response (GO:0016064)3.34982962
64positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.34455219
65granulocyte activation (GO:0036230)3.33327953
66regulation of T cell mediated cytotoxicity (GO:0001914)3.32067891
67macrophage activation (GO:0042116)3.31791656
68thymic T cell selection (GO:0045061)3.30168692
69dendritic cell migration (GO:0036336)3.28221418
70myeloid cell activation involved in immune response (GO:0002275)3.27966067
71regulation of alpha-beta T cell proliferation (GO:0046640)3.26979576
72negative regulation of protein autophosphorylation (GO:0031953)3.24165215
73regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.23393994
74regulation of mast cell degranulation (GO:0043304)3.23259574
75negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.23095286
76response to muramyl dipeptide (GO:0032495)3.21896501
77leukocyte migration involved in inflammatory response (GO:0002523)3.21664857
78dendritic cell chemotaxis (GO:0002407)3.21346931
79positive regulation of T cell mediated cytotoxicity (GO:0001916)3.19527390
80regulation of natural killer cell mediated immunity (GO:0002715)3.18748950
81regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.18748950
82growth hormone receptor signaling pathway (GO:0060396)3.18188604
83positive regulation of granulocyte differentiation (GO:0030854)3.15627824
84brown fat cell differentiation (GO:0050873)3.15338459
85tolerance induction (GO:0002507)3.14777630
86production of molecular mediator involved in inflammatory response (GO:0002532)3.12456077
87negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.10814999
88regulation of regulatory T cell differentiation (GO:0045589)3.10443832
89negative regulation of type 2 immune response (GO:0002829)3.10060491
90positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.07727151
91positive regulation of mast cell activation (GO:0033005)3.03884737
92negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.03438147
93negative regulation of T-helper cell differentiation (GO:0045623)3.03438147
94regulation of myeloid leukocyte mediated immunity (GO:0002886)3.02518210
95positive regulation of tolerance induction (GO:0002645)3.01635533
96fatty acid beta-oxidation (GO:0006635)2.99402732
97regulation of mast cell activation involved in immune response (GO:0033006)2.98679613
98tricarboxylic acid metabolic process (GO:0072350)2.98447314
99vascular endothelial growth factor signaling pathway (GO:0038084)2.96302793
100myeloid leukocyte mediated immunity (GO:0002444)2.94697012
101apoptotic cell clearance (GO:0043277)2.93989641
102regulation of interferon-beta biosynthetic process (GO:0045357)2.93599226
103cellular response to growth hormone stimulus (GO:0071378)2.93486391
104regulation of leukocyte degranulation (GO:0043300)2.89993872
105interferon-gamma-mediated signaling pathway (GO:0060333)2.89670917
106negative regulation of adaptive immune response (GO:0002820)2.88713782
107defense response to protozoan (GO:0042832)2.87508814
108negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.86528594
109carnitine transmembrane transport (GO:1902603)2.82426741
110JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.81582843
111white fat cell differentiation (GO:0050872)2.79300451
112positive regulation of B cell differentiation (GO:0045579)2.78008089
113fibroblast migration (GO:0010761)2.76775636
114intracellular lipid transport (GO:0032365)2.68893617
115positive regulation of natural killer cell differentiation (GO:0032825)2.67337843
116regulation of fatty acid oxidation (GO:0046320)2.66100824
117carnitine transport (GO:0015879)2.65634142
118amino-acid betaine transport (GO:0015838)2.65634142
119positive regulation of protein deacetylation (GO:0090312)2.64467515
120lipid storage (GO:0019915)2.62749273
121negative regulation of stress fiber assembly (GO:0051497)2.62539580
122surfactant homeostasis (GO:0043129)2.62388501
123fatty acid oxidation (GO:0019395)2.61829131
124morphogenesis of an endothelium (GO:0003159)2.59909640
125endothelial tube morphogenesis (GO:0061154)2.59909640
126cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.57931013
127lipid oxidation (GO:0034440)2.54334456
128biotin metabolic process (GO:0006768)2.53383175
129positive regulation of fatty acid oxidation (GO:0046321)2.52583002
130basement membrane organization (GO:0071711)2.50906379
131endothelial cell chemotaxis (GO:0035767)2.49623435
132transcytosis (GO:0045056)2.49492704
133positive regulation of fatty acid beta-oxidation (GO:0032000)2.48344229
134megakaryocyte development (GO:0035855)2.48301488
135positive regulation of p38MAPK cascade (GO:1900745)2.45351788
136branched-chain amino acid metabolic process (GO:0009081)2.45051939
137fatty acid catabolic process (GO:0009062)2.44058217
138hemidesmosome assembly (GO:0031581)2.43512437
139positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.43188890
140negative regulation of phagocytosis (GO:0050765)2.42738397
141regulation of interleukin-12 biosynthetic process (GO:0045075)2.41877358
142cellular response to zinc ion (GO:0071294)2.41511021
143triglyceride catabolic process (GO:0019433)2.39293772
144negative regulation of lipid storage (GO:0010888)2.37140823
145lipid particle organization (GO:0034389)2.36967723
146positive thymic T cell selection (GO:0045059)2.34626671
147response to laminar fluid shear stress (GO:0034616)2.33309270
148COPI coating of Golgi vesicle (GO:0048205)2.32890719
149Golgi transport vesicle coating (GO:0048200)2.32890719
150blood vessel maturation (GO:0001955)2.32383437
151hepatocyte apoptotic process (GO:0097284)2.31641844
152epithelial cell-cell adhesion (GO:0090136)2.30853802
153regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.29698127
154response to type I interferon (GO:0034340)2.29107460
155keratan sulfate catabolic process (GO:0042340)2.28876883
156regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.28751954
157response to interferon-alpha (GO:0035455)2.28312889
158negative regulation of glycoprotein biosynthetic process (GO:0010561)2.25934038
159regulation of fatty acid beta-oxidation (GO:0031998)2.23791485
160leukocyte tethering or rolling (GO:0050901)2.22976733
161regulation of B cell receptor signaling pathway (GO:0050855)2.22768318
162type I interferon signaling pathway (GO:0060337)2.18171072
163cellular response to type I interferon (GO:0071357)2.18171072
164regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.17923188
165pentose-phosphate shunt (GO:0006098)2.17542845
166germ cell migration (GO:0008354)2.17489271
167regulation of B cell differentiation (GO:0045577)2.17338210
168regulation of erythrocyte differentiation (GO:0045646)2.17056065
169ribosomal small subunit assembly (GO:0000028)2.16988202
170angiogenesis involved in wound healing (GO:0060055)2.16884714
171positive regulation of lipid storage (GO:0010884)2.16701463
172ovulation from ovarian follicle (GO:0001542)2.16682844
173regulation of p38MAPK cascade (GO:1900744)2.16659659
174positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.16248583
175regulation of macrophage derived foam cell differentiation (GO:0010743)2.14321395
176regulation of response to interferon-gamma (GO:0060330)2.14089740
177macrophage differentiation (GO:0030225)2.13583555
178regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.13266898
179pinocytosis (GO:0006907)2.13145953
180negative regulation of innate immune response (GO:0045824)2.13100439

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.12353288
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.18486850
3GATA1_22025678_ChIP-Seq_K562_Human2.99361168
4CLOCK_20551151_ChIP-Seq_293T_Human2.91415648
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.74849750
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.73642889
7* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.72446530
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.71504214
9SCL_19346495_ChIP-Seq_HPC-7_Human2.67891794
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.38899743
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.36904118
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.25730572
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.22569711
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.20766795
15MYC_22102868_ChIP-Seq_BL_Human2.16697129
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.15088520
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.11188849
18VDR_21846776_ChIP-Seq_THP-1_Human2.02652695
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97734987
20* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92453165
21MYB_21317192_ChIP-Seq_ERMYB_Mouse1.92211655
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91830739
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91752989
24* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89629950
25* TCF7_22412390_ChIP-Seq_EML_Mouse1.89268350
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.84741647
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.83585629
28* MAF_26560356_Chip-Seq_TH1_Human1.80983411
29RUNX_20019798_ChIP-Seq_JUKART_Human1.80365664
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.80148920
31* GATA2_21666600_ChIP-Seq_HMVEC_Human1.79796394
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.78435633
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77960904
34* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.77166980
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.75700122
36* VDR_24787735_ChIP-Seq_THP-1_Human1.70937308
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70332092
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.67263051
39* RXR_22158963_ChIP-Seq_LIVER_Mouse1.66908411
40* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60124550
41TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59649318
42* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59362907
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.57880994
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57044433
45MYB_26560356_Chip-Seq_TH2_Human1.56980292
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56474835
47UTX_26944678_Chip-Seq_JUKART_Human1.54193579
48VDR_24763502_ChIP-Seq_THP-1_Human1.53842875
49* LXR_22158963_ChIP-Seq_LIVER_Mouse1.52819168
50* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50778176
51MYB_26560356_Chip-Seq_TH1_Human1.42728728
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42205248
53GATA1_19941826_ChIP-Seq_K562_Human1.41864253
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41787913
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41759660
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.41554849
57SPI1_23127762_ChIP-Seq_K562_Human1.39965366
58* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39843861
59* GATA3_26560356_Chip-Seq_TH2_Human1.39550003
60FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.39339222
61* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39258858
62KDM2B_26808549_Chip-Seq_DND41_Human1.35340868
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33743796
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.32976236
65* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31911135
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31566698
67* FOXO3_23340844_ChIP-Seq_DLD1_Human1.31494549
68PU_27001747_Chip-Seq_BMDM_Mouse1.31143423
69* SPI1_23547873_ChIP-Seq_NB4_Human1.30337992
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26606725
71TBX20_22080862_ChIP-Seq_HEART_Mouse1.25656116
72TBX20_22328084_ChIP-Seq_HEART_Mouse1.25656116
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25287949
74ZNF263_19887448_ChIP-Seq_K562_Human1.24739418
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24497516
76KDM2B_26808549_Chip-Seq_JURKAT_Human1.24137358
77SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23839641
78RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.23577877
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23057367
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22213118
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22063802
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21763190
83* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21739429
84GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21675089
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21317652
86NCOR1_26117541_ChIP-Seq_K562_Human1.21185469
87PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19805450
88* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18831500
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18829821
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18645018
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17164298
92GATA2_19941826_ChIP-Seq_K562_Human1.16777518
93Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15842975
94RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15734288
95* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15161780
96* RACK7_27058665_Chip-Seq_MCF-7_Human1.15013168
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13518045
98* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12831537
99* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12541282
100* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12175803
101STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11492741
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10924970
103* GATA3_27048872_Chip-Seq_THYMUS_Human1.10743946
104* GATA1_19941827_ChIP-Seq_MEL_Mouse1.10575658
105TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10243862
106STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08809182
107LXR_22292898_ChIP-Seq_THP-1_Human1.07354205
108CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04862007
109CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04479354
110CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04334994
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03948896
112P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03739083
113RUNX1_27514584_Chip-Seq_MCF-7_Human1.03045735
114STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01852963
115* MAF_26560356_Chip-Seq_TH2_Human1.00652089
116ATF3_27146783_Chip-Seq_COLON_Human0.98934009
117* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98894771
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97990357
119VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96278588
120* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95838520
121SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95726176
122GATA6_25053715_ChIP-Seq_YYC3_Human0.95512034
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93232449
124SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91229279
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89949557
126* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85761186
127NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84306505
128SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83871154
129RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83356101
130BCL6_27268052_Chip-Seq_Bcells_Human0.81106439
131IKZF1_21737484_ChIP-ChIP_HCT116_Human0.80912725
132CIITA_25753668_ChIP-Seq_RAJI_Human0.79799035
133SMRT_27268052_Chip-Seq_Bcells_Human0.78350333

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose3.36060750
2MP0003191_abnormal_cellular_cholesterol2.60266141
3MP0005666_abnormal_adipose_tissue2.55003348
4MP0004185_abnormal_adipocyte_glucose2.31536732
5MP0003300_gastrointestinal_ulcer2.26942427
6* MP0004130_abnormal_muscle_cell2.22466983
7MP0003724_increased_susceptibility_to2.17891553
8MP0008260_abnormal_autophagy2.09649619
9MP0002166_altered_tumor_susceptibility2.02840641
10MP0006054_spinal_hemorrhage2.02043669
11MP0008438_abnormal_cutaneous_collagen1.97295416
12MP0004381_abnormal_hair_follicle1.85373208
13MP0005375_adipose_tissue_phenotype1.84821309
14MP0010368_abnormal_lymphatic_system1.84185965
15MP0003705_abnormal_hypodermis_morpholog1.82989714
16MP0003566_abnormal_cell_adhesion1.81960222
17MP0001835_abnormal_antigen_presentation1.81628367
18MP0001879_abnormal_lymphatic_vessel1.80073978
19MP0002132_abnormal_respiratory_system1.74717710
20MP0009333_abnormal_splenocyte_physiolog1.73901227
21MP0000703_abnormal_thymus_morphology1.71079372
22MP0003828_pulmonary_edema1.68650105
23MP0002877_abnormal_melanocyte_morpholog1.66997673
24MP0000685_abnormal_immune_system1.66145713
25MP0004883_abnormal_blood_vessel1.64004245
26MP0005058_abnormal_lysosome_morphology1.62271324
27MP0005451_abnormal_body_composition1.57600304
28MP0009278_abnormal_bone_marrow1.56514210
29* MP0002429_abnormal_blood_cell1.51431958
30MP0003172_abnormal_lysosome_physiology1.45765994
31MP0000465_gastrointestinal_hemorrhage1.44711667
32MP0010234_abnormal_vibrissa_follicle1.44331290
33MP0000343_altered_response_to1.42673624
34MP0005464_abnormal_platelet_physiology1.41720684
35MP0010155_abnormal_intestine_physiology1.38337640
36MP0005275_abnormal_skin_tensile1.38029662
37MP0003436_decreased_susceptibility_to1.36903785
38MP0005397_hematopoietic_system_phenotyp1.34735874
39MP0001545_abnormal_hematopoietic_system1.34735874
40MP0002006_tumorigenesis1.32715418
41MP0003690_abnormal_glial_cell1.32512750
42MP0002396_abnormal_hematopoietic_system1.31346660
43MP0002837_dystrophic_cardiac_calcinosis1.31016780
44MP0004084_abnormal_cardiac_muscle1.30368474
45MP0003045_fibrosis1.29390007
46MP0005671_abnormal_response_to1.29173168
47MP0002971_abnormal_brown_adipose1.28888534
48MP0002254_reproductive_system_inflammat1.28786539
49MP0004808_abnormal_hematopoietic_stem1.28389194
50MP0000013_abnormal_adipose_tissue1.27294056
51MP0001873_stomach_inflammation1.26610114
52MP0003763_abnormal_thymus_physiology1.25456090
53MP0004272_abnormal_basement_membrane1.25250097
54MP0009785_altered_susceptibility_to1.24850370
55MP0009764_decreased_sensitivity_to1.24402818
56MP0005164_abnormal_response_to1.23588813
57MP0002998_abnormal_bone_remodeling1.23487591
58MP0003183_abnormal_peptide_metabolism1.21508846
59MP0005167_abnormal_blood-brain_barrier1.19625755
60MP0000003_abnormal_adipose_tissue1.18674492
61MP0002277_abnormal_respiratory_mucosa1.17567247
62MP0001800_abnormal_humoral_immune1.16563655
63MP0005025_abnormal_response_to1.15360015
64MP0004264_abnormal_extraembryonic_tissu1.15111318
65MP0009115_abnormal_fat_cell1.14505204
66MP0010352_gastrointestinal_tract_polyps1.13759676
67MP0003279_aneurysm1.12954615
68MP0001790_abnormal_immune_system1.12882842
69MP0005387_immune_system_phenotype1.12882842
70MP0002452_abnormal_antigen_presenting1.12698023
71MP0005075_abnormal_melanosome_morpholog1.11251212
72MP0005310_abnormal_salivary_gland1.09565623
73MP0001533_abnormal_skeleton_physiology1.09337295
74MP0002419_abnormal_innate_immunity1.08895735
75* MP0009643_abnormal_urine_homeostasis1.07240185
76MP0004947_skin_inflammation1.05207793
77MP0002009_preneoplasia1.04583821
78MP0005334_abnormal_fat_pad1.04327537
79MP0008961_abnormal_basal_metabolism1.03979763
80MP0005023_abnormal_wound_healing1.03313192
81* MP0002420_abnormal_adaptive_immunity1.02764599
82* MP0001819_abnormal_immune_cell1.01700362
83MP0001958_emphysema1.01410602
84MP0010630_abnormal_cardiac_muscle1.00815631
85MP0001845_abnormal_inflammatory_respons1.00595552
86MP0002933_joint_inflammation1.00489320
87MP0001853_heart_inflammation0.99554326
88MP0002723_abnormal_immune_serum0.98750591
89MP0005000_abnormal_immune_tolerance0.98393014
90MP0002060_abnormal_skin_morphology0.96865603
91* MP0000609_abnormal_liver_physiology0.95969838
92* MP0010329_abnormal_lipoprotein_level0.95321817
93MP0003866_abnormal_defecation0.94345367
94MP0004036_abnormal_muscle_relaxation0.94105513
95MP0003656_abnormal_erythrocyte_physiolo0.91578250
96MP0008004_abnormal_stomach_pH0.89157642
97MP0005166_decreased_susceptibility_to0.89137066
98MP0002405_respiratory_system_inflammati0.88990200
99MP0003075_altered_response_to0.88830641
100MP0000767_abnormal_smooth_muscle0.88261800
101* MP0002398_abnormal_bone_marrow0.88145680
102MP0000689_abnormal_spleen_morphology0.87743689
103MP0008469_abnormal_protein_level0.87100543
104MP0000604_amyloidosis0.86572853
105MP0005365_abnormal_bile_salt0.84566141
106MP0003303_peritoneal_inflammation0.84486915
107MP0000249_abnormal_blood_vessel0.84037002
108MP0006082_CNS_inflammation0.83788646
109MP0003448_altered_tumor_morphology0.83304471
110* MP0000716_abnormal_immune_system0.82852911
111MP0002970_abnormal_white_adipose0.82637619
112MP0005390_skeleton_phenotype0.82443789
113* MP0002722_abnormal_immune_system0.81203101
114* MP0002118_abnormal_lipid_homeostasis0.81115202
115MP0004087_abnormal_muscle_fiber0.80560639
116* MP0002136_abnormal_kidney_physiology0.79791630
117MP0001986_abnormal_taste_sensitivity0.79731692
118MP0003221_abnormal_cardiomyocyte_apopto0.79650452
119MP0001851_eye_inflammation0.79359508
120* MP0005385_cardiovascular_system_phenoty0.79068637
121* MP0001544_abnormal_cardiovascular_syste0.79068637
122MP0001756_abnormal_urination0.79001308
123MP0003453_abnormal_keratinocyte_physiol0.78622148
124MP0000858_altered_metastatic_potential0.78132832
125* MP0009763_increased_sensitivity_to0.78115321
126MP0002148_abnormal_hypersensitivity_rea0.77538644
127MP0006138_congestive_heart_failure0.76627647
128MP0001663_abnormal_digestive_system0.73931152
129MP0002133_abnormal_respiratory_system0.73855889
130MP0005388_respiratory_system_phenotype0.73855889
131MP0003091_abnormal_cell_migration0.72437668
132MP0004510_myositis0.68898024
133MP0003795_abnormal_bone_structure0.65239752
134MP0000015_abnormal_ear_pigmentation0.64308609
135MP0009765_abnormal_xenobiotic_induced0.60171733
136MP0002332_abnormal_exercise_endurance0.57578193
137MP0002138_abnormal_hepatobiliary_system0.54760981
138MP0000569_abnormal_digit_pigmentation0.54739759
139* MP0008874_decreased_physiological_sensi0.52771768
140MP0003329_amyloid_beta_deposits0.51311413
141MP0005376_homeostasis/metabolism_phenot0.48968853
142* MP0004484_altered_response_of0.48502700
143MP0003252_abnormal_bile_duct0.47948828

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.52724188
2Orchitis (HP:0100796)5.21156465
3Retrobulbar optic neuritis (HP:0100654)4.97037142
4Optic neuritis (HP:0100653)4.97037142
5Stomatitis (HP:0010280)4.69487225
6Abnormality of macrophages (HP:0004311)4.63480164
7Recurrent gram-negative bacterial infections (HP:0005420)4.49322237
8Gastrointestinal infarctions (HP:0005244)4.39705626
9T lymphocytopenia (HP:0005403)4.24604688
10Recurrent fungal infections (HP:0002841)4.23838431
11Hematochezia (HP:0002573)4.01959706
12Abnormality of T cell number (HP:0011839)3.99060422
13Meningitis (HP:0001287)3.91373492
14Mediastinal lymphadenopathy (HP:0100721)3.89027719
15Keratoconjunctivitis sicca (HP:0001097)3.80051994
16Recurrent skin infections (HP:0001581)3.75081472
17Encephalitis (HP:0002383)3.68983799
18Cerebral aneurysm (HP:0004944)3.60589517
19Chronic obstructive pulmonary disease (HP:0006510)3.59247642
20Obstructive lung disease (HP:0006536)3.59247642
21Chronic mucocutaneous candidiasis (HP:0002728)3.53339515
22Recurrent cutaneous fungal infections (HP:0011370)3.53339515
23Gingivitis (HP:0000230)3.51819040
24Keratoconjunctivitis (HP:0001096)3.51406961
25Vasculitis (HP:0002633)3.41499231
26Aortic aneurysm (HP:0004942)3.41155370
27Spontaneous hematomas (HP:0007420)3.33544588
28Chest pain (HP:0100749)3.24042239
29Abnormality of the nasal mucosa (HP:0000433)3.23148521
30Abnormality of T cells (HP:0002843)3.16697059
31Leukocytosis (HP:0001974)3.11923628
32Urticaria (HP:0001025)3.09992092
33Pulmonary infiltrates (HP:0002113)3.07284547
34Panhypogammaglobulinemia (HP:0003139)3.00418944
35Hemoptysis (HP:0002105)2.97034059
36Facial diplegia (HP:0001349)2.96878325
37Gingival bleeding (HP:0000225)2.88042772
38Granulocytopenia (HP:0001913)2.87896188
39Systemic lupus erythematosus (HP:0002725)2.83701405
40Polycythemia (HP:0001901)2.81091253
41Hypoglycemic coma (HP:0001325)2.75110542
42Asymmetric septal hypertrophy (HP:0001670)2.73980232
43Peritonitis (HP:0002586)2.73704181
44Right ventricular cardiomyopathy (HP:0011663)2.72312872
45Episodic fever (HP:0001954)2.71588830
46Myoglobinuria (HP:0002913)2.70720236
47Aortic dissection (HP:0002647)2.68112705
48Pulmonary embolism (HP:0002204)2.66003830
49Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.60443790
50Interstitial pulmonary disease (HP:0006530)2.59551671
51Increased connective tissue (HP:0009025)2.58795025
52Oligomenorrhea (HP:0000876)2.58505242
53Colitis (HP:0002583)2.56218756
54Eosinophilia (HP:0001880)2.54092346
55Vacuolated lymphocytes (HP:0001922)2.53759226
56Hypochromic microcytic anemia (HP:0004840)2.53142017
57Prolonged bleeding time (HP:0003010)2.50613154
58Broad metatarsal (HP:0001783)2.49884274
59Hypochromic anemia (HP:0001931)2.49097336
60Increased IgM level (HP:0003496)2.48100067
61Osteomyelitis (HP:0002754)2.46085057
62Agammaglobulinemia (HP:0004432)2.43519663
63Anorexia (HP:0002039)2.41060373
64Thrombocytosis (HP:0001894)2.39823443
65Aneurysm (HP:0002617)2.37286176
66Lymphopenia (HP:0001888)2.37016918
67Complement deficiency (HP:0004431)2.36482041
68Growth hormone excess (HP:0000845)2.35829351
69Abnormality of T cell physiology (HP:0011840)2.35709427
70Inflammation of the large intestine (HP:0002037)2.34989455
71Sepsis (HP:0100806)2.34886646
72Amyloidosis (HP:0011034)2.34615263
73Ankle contracture (HP:0006466)2.33874693
74Abnormality of eosinophils (HP:0001879)2.33669552
75Papilledema (HP:0001085)2.32336452
76Acanthosis nigricans (HP:0000956)2.31316432
77Gastrointestinal inflammation (HP:0004386)2.30880824
78Rhabdomyolysis (HP:0003201)2.30619002
79Eczematoid dermatitis (HP:0000976)2.29363441
80Increased cerebral lipofuscin (HP:0011813)2.28297754
81Nasal polyposis (HP:0100582)2.27935003
82Dysostosis multiplex (HP:0000943)2.27858893
83Abnormality of the pleura (HP:0002103)2.27370718
84Hypertriglyceridemia (HP:0002155)2.26441070
85Abnormality of fatty-acid metabolism (HP:0004359)2.25904753
86Papilloma (HP:0012740)2.25668843
87Verrucae (HP:0200043)2.25668843
88Hypergammaglobulinemia (HP:0010702)2.23632434
89Insulin-resistant diabetes mellitus (HP:0000831)2.22694935
90Gangrene (HP:0100758)2.22337059
91Abnormality of cells of the lymphoid lineage (HP:0012140)2.20919892
92Abnormality of the peritoneum (HP:0002585)2.19849865
93Rectal prolapse (HP:0002035)2.18052339
94Ventricular tachycardia (HP:0004756)2.16553517
95Difficulty running (HP:0009046)2.16544177
96Viral hepatitis (HP:0006562)2.15546855
97Glomerulonephritis (HP:0000099)2.14935768
98Myositis (HP:0100614)2.14791813
99Generalized aminoaciduria (HP:0002909)2.14267308
100Fatigue (HP:0012378)2.14210443
101Microcytic anemia (HP:0001935)2.13963874
102Reduced subcutaneous adipose tissue (HP:0003758)2.13471859
103Chronic otitis media (HP:0000389)2.13437236
104Type 1 muscle fiber predominance (HP:0003803)2.13324714
105Urinary glycosaminoglycan excretion (HP:0003541)2.10492347
106Mucopolysacchariduria (HP:0008155)2.10492347
107Subacute progressive viral hepatitis (HP:0006572)2.09443448
108Esophageal varix (HP:0002040)2.09233326
109Slow saccadic eye movements (HP:0000514)2.07603818
110Insulin resistance (HP:0000855)2.06591765
111Abnormality of the endocardium (HP:0004306)2.06146986
112Nephritis (HP:0000123)2.05877213
113Skin ulcer (HP:0200042)2.05214568
114IgM deficiency (HP:0002850)2.04092674
115Acute hepatic failure (HP:0006554)2.03802422
116Autoimmune hemolytic anemia (HP:0001890)2.03122723
117Bone cyst (HP:0012062)2.03006467
118Vertigo (HP:0002321)2.02016540
119Ketoacidosis (HP:0001993)2.01447675
120Glomerulopathy (HP:0100820)2.00544659
121Striae distensae (HP:0001065)1.99180537
122Keratitis (HP:0000491)1.99065168
123Severe combined immunodeficiency (HP:0004430)1.99036410
124Autoimmune thrombocytopenia (HP:0001973)1.98012395
125Spondylolisthesis (HP:0003302)1.96642394
126Abnormal delayed hypersensitivity skin test (HP:0002963)1.96307516
127Arterial tortuosity (HP:0005116)1.94783640
128Ulnar deviation of the wrist (HP:0003049)1.94361979
129Abnormal platelet function (HP:0011869)1.94289534
130Impaired platelet aggregation (HP:0003540)1.94289534
131Increased neuronal autofluorescent lipopigment (HP:0002074)1.93922882
132Osteolytic defects of the phalanges of the hand (HP:0009771)1.93268761
133Osteolytic defects of the hand bones (HP:0009699)1.93268761
134Abnormality of mucopolysaccharide metabolism (HP:0011020)1.91523778
135Abnormality of polysaccharide metabolism (HP:0011012)1.91523778
136Abnormality of glycosaminoglycan metabolism (HP:0004371)1.91523778
137Recurrent bronchitis (HP:0002837)1.90623153
138Hemorrhage of the eye (HP:0011885)1.90180407
139Bicuspid aortic valve (HP:0001647)1.89790858
140Hyporeflexia of lower limbs (HP:0002600)1.89361805
141IgG deficiency (HP:0004315)1.89341230
142Enlarged penis (HP:0000040)1.89156892
143Acne (HP:0001061)1.88639590
144Lipoatrophy (HP:0100578)1.87440667
145Hyperglycinuria (HP:0003108)1.85999860
146Joint swelling (HP:0001386)1.84580771
147Stomach cancer (HP:0012126)1.84495229
148Recurrent abscess formation (HP:0002722)1.83940389
149Mitral valve prolapse (HP:0001634)1.83903330
150Cardiomegaly (HP:0001640)1.83617408
151Skin rash (HP:0000988)1.83576082
152Muscle fiber splitting (HP:0003555)1.82361186
153Thin bony cortex (HP:0002753)1.82296237
154Epistaxis (HP:0000421)1.81233064
155Petechiae (HP:0000967)1.81214227
156Exercise-induced myalgia (HP:0003738)1.80701864
157Elevated erythrocyte sedimentation rate (HP:0003565)1.80498957
158Pustule (HP:0200039)1.80196990
159Abnormal platelet volume (HP:0011876)1.79728527
160Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.78348694
161Recurrent viral infections (HP:0004429)1.76725373
162Arterial thrombosis (HP:0004420)1.74819560
163Myocardial infarction (HP:0001658)1.73891117
164Cellulitis (HP:0100658)1.73507182
165Vascular tortuosity (HP:0004948)1.73313391
166Abnormality of the fingertips (HP:0001211)1.70052991
167Emphysema (HP:0002097)1.69887642
168Visceral angiomatosis (HP:0100761)1.68948794
169Gastrointestinal stroma tumor (HP:0100723)1.67024583
170Dicarboxylic aciduria (HP:0003215)1.66670106
171Abnormality of dicarboxylic acid metabolism (HP:0010995)1.66670106
172Abnormality of complement system (HP:0005339)1.65967940
173Increased IgE level (HP:0003212)1.65753128
174Abnormality of skeletal muscle fiber size (HP:0012084)1.65488479
175Exercise-induced muscle cramps (HP:0003710)1.64380039

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.22546108
2TGFBR23.94402890
3TRIB33.63576012
4PKN23.26101570
5ERN12.91229204
6BLK2.78761590
7TIE12.75180758
8EEF2K2.65948136
9PRPF4B2.58353375
10FES2.54067681
11GRK62.45755510
12IRAK42.29046533
13FLT32.27870363
14TXK2.18308635
15CAMK1D2.15389943
16MAP4K12.15291662
17TTN2.13189302
18MAP2K32.00234267
19BCKDK1.98562539
20MAPK151.82623021
21RIPK11.79898350
22TNK21.77887722
23TYK21.77294196
24TGFBR11.76646855
25JAK31.70592593
26FGFR41.66096997
27KDR1.64241488
28MAP3K141.58019809
29MAP3K131.56235005
30PTK61.51430891
31LRRK21.50442898
32SIK11.49696272
33MAPKAPK31.48730357
34STK101.48027368
35KIT1.45681602
36ZAP701.39223048
37PIK3CG1.38424296
38CAMK1G1.37265734
39FGR1.36739599
40JAK11.36299541
41LYN1.31886312
42EPHB11.30346065
43MYLK1.29994338
44TBK11.29941911
45FGFR31.24245071
46KSR21.23108875
47YES11.22408846
48TAOK31.22017366
49TAOK11.20696375
50SIK31.19757207
51BTK1.18998096
52MAP3K101.18249598
53CSF1R1.16480706
54MAP3K31.14143052
55LMTK21.10125419
56MARK21.09709731
57MARK31.02916302
58MAP3K61.02573631
59PAK41.01988194
60IKBKE1.01363392
61INSRR0.99661489
62MAP3K110.98693925
63RPS6KB20.98026805
64JAK20.94293032
65FRK0.94205193
66TEC0.93254055
67ITK0.92965004
68CDK60.92788423
69CSK0.90961278
70BMPR20.90335692
71NLK0.88019713
72PRKAA20.87396462
73PDGFRA0.83734690
74CDK90.83528608
75IRAK10.82220733
76NEK90.81880272
77MAPK70.80211728
78MAP3K70.78973865
79TRPM70.76358291
80MAP2K20.76233989
81CAMKK20.74991542
82EPHA30.74909602
83SGK30.74614187
84SGK20.73985862
85MATK0.72794581
86SIK20.71334728
87PDK20.70729811
88IRAK30.70140515
89FYN0.68005437
90MST1R0.67875251
91DMPK0.67597832
92PDK40.67240433
93PDK30.67240433
94PRKG20.66076134
95RET0.64981335
96PRKCQ0.63572674
97STK380.63270925
98PIK3CA0.63266839
99PDPK10.63171812
100CAMKK10.62737849
101LCK0.61765690
102PTK2B0.58957789
103PAK20.58944452
104IKBKB0.57543515
105PDGFRB0.56842915
106HCK0.56407389
107HIPK20.56036524
108SCYL20.54852863
109PASK0.53635469
110MAPK110.52003276
111CHUK0.51702182
112CDK190.51658539
113PRKD10.51583019
114LATS10.51471091
115ILK0.51138769
116RAF10.50913188
117PIM10.50645530
118STK110.50589819
119MAP2K40.50282143
120RPS6KA40.50024078
121PRKD20.49687985
122MAP3K20.49424949
123MTOR0.48653935
124CDC42BPA0.47883640
125IRAK20.46449359
126OBSCN0.46307286
127MAP3K50.44565079
128CDK40.44295190
129TESK20.43815942
130NME20.42795483
131CDK120.42464549
132SGK2230.42150645
133SGK4940.42150645
134MAPK120.40438241
135RPS6KA60.39415072
136MAP3K10.38958830
137SYK0.38561980
138PDK10.38350018
139TAOK20.37759899
140MAP2K60.37685302
141KSR10.37563573
142IGF1R0.37183301
143RPS6KL10.37021991
144RPS6KC10.37021991
145DYRK1B0.36762264
146PRKCH0.35127420
147MAPKAPK20.35014177

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.61462027
2Graft-versus-host disease_Homo sapiens_hsa053322.44624725
3Allograft rejection_Homo sapiens_hsa053302.35944548
4Fatty acid degradation_Homo sapiens_hsa000712.30222156
5Autoimmune thyroid disease_Homo sapiens_hsa053202.27200120
6Propanoate metabolism_Homo sapiens_hsa006402.19837222
7Other glycan degradation_Homo sapiens_hsa005112.01249645
8PPAR signaling pathway_Homo sapiens_hsa033202.00771410
9Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.00474484
10Caffeine metabolism_Homo sapiens_hsa002321.91916698
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91288982
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.75664979
13Staphylococcus aureus infection_Homo sapiens_hsa051501.74097932
14Type I diabetes mellitus_Homo sapiens_hsa049401.68750225
15Fatty acid metabolism_Homo sapiens_hsa012121.64863006
16Insulin resistance_Homo sapiens_hsa049311.63076728
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.61140344
18Osteoclast differentiation_Homo sapiens_hsa043801.59285111
19Antigen processing and presentation_Homo sapiens_hsa046121.56339093
20Leishmaniasis_Homo sapiens_hsa051401.53486269
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52220218
22Toxoplasmosis_Homo sapiens_hsa051451.50041427
23B cell receptor signaling pathway_Homo sapiens_hsa046621.49353428
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.48057603
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.44835142
26Non-small cell lung cancer_Homo sapiens_hsa052231.43109470
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33397893
28Primary immunodeficiency_Homo sapiens_hsa053401.31479115
29Acute myeloid leukemia_Homo sapiens_hsa052211.31343897
30Platelet activation_Homo sapiens_hsa046111.31174953
31Lysosome_Homo sapiens_hsa041421.27096308
32ECM-receptor interaction_Homo sapiens_hsa045121.22923378
33Focal adhesion_Homo sapiens_hsa045101.20877407
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.19453698
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18428013
36Chronic myeloid leukemia_Homo sapiens_hsa052201.16955828
37Fatty acid biosynthesis_Homo sapiens_hsa000611.14958611
38Hematopoietic cell lineage_Homo sapiens_hsa046401.14119669
39Phagosome_Homo sapiens_hsa041451.13883689
40Glycerolipid metabolism_Homo sapiens_hsa005611.13364526
41AMPK signaling pathway_Homo sapiens_hsa041521.13088744
42Measles_Homo sapiens_hsa051621.11378631
43Asthma_Homo sapiens_hsa053101.08196048
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07441259
45Small cell lung cancer_Homo sapiens_hsa052221.03959629
46ABC transporters_Homo sapiens_hsa020101.02182455
47Pertussis_Homo sapiens_hsa051330.99786588
48Lysine degradation_Homo sapiens_hsa003100.99710469
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98559321
50Notch signaling pathway_Homo sapiens_hsa043300.97491190
51Renal cell carcinoma_Homo sapiens_hsa052110.95455032
52Protein digestion and absorption_Homo sapiens_hsa049740.95409182
53Adherens junction_Homo sapiens_hsa045200.95058132
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.94740091
55Fat digestion and absorption_Homo sapiens_hsa049750.94439882
56Legionellosis_Homo sapiens_hsa051340.94369417
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93399238
58Pancreatic cancer_Homo sapiens_hsa052120.92938811
59Influenza A_Homo sapiens_hsa051640.92180293
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91020054
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.89754316
62Insulin signaling pathway_Homo sapiens_hsa049100.89730891
63Viral myocarditis_Homo sapiens_hsa054160.89347411
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88814328
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86602919
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85636660
67Endometrial cancer_Homo sapiens_hsa052130.84762673
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82392580
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82376021
70African trypanosomiasis_Homo sapiens_hsa051430.81433461
71Malaria_Homo sapiens_hsa051440.80705445
72Carbon metabolism_Homo sapiens_hsa012000.80472125
73Starch and sucrose metabolism_Homo sapiens_hsa005000.79762531
74Amoebiasis_Homo sapiens_hsa051460.79475987
75Choline metabolism in cancer_Homo sapiens_hsa052310.79299319
76Prolactin signaling pathway_Homo sapiens_hsa049170.78752842
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.78060309
78beta-Alanine metabolism_Homo sapiens_hsa004100.77735585
79Shigellosis_Homo sapiens_hsa051310.77340699
80Dorso-ventral axis formation_Homo sapiens_hsa043200.76759999
81Endocytosis_Homo sapiens_hsa041440.76663679
82Herpes simplex infection_Homo sapiens_hsa051680.74749362
83Apoptosis_Homo sapiens_hsa042100.73806964
84Inositol phosphate metabolism_Homo sapiens_hsa005620.73438570
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.73095797
86Hepatitis C_Homo sapiens_hsa051600.72883997
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.72411739
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.71629482
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71511434
90Proteoglycans in cancer_Homo sapiens_hsa052050.70862074
91Pyruvate metabolism_Homo sapiens_hsa006200.70515644
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68976353
93TNF signaling pathway_Homo sapiens_hsa046680.68532576
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68171770
95Complement and coagulation cascades_Homo sapiens_hsa046100.68087399
96Galactose metabolism_Homo sapiens_hsa000520.68075991
97GnRH signaling pathway_Homo sapiens_hsa049120.67606059
98HIF-1 signaling pathway_Homo sapiens_hsa040660.67356651
99Salmonella infection_Homo sapiens_hsa051320.67288773
100Colorectal cancer_Homo sapiens_hsa052100.67207484
101Rheumatoid arthritis_Homo sapiens_hsa053230.66356546
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66227882
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65193042
104Thyroid cancer_Homo sapiens_hsa052160.63943456
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63296741
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63296520
107Hepatitis B_Homo sapiens_hsa051610.62595576
108Viral carcinogenesis_Homo sapiens_hsa052030.62303003
109Tuberculosis_Homo sapiens_hsa051520.62179912
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59902512
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59595805
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59407595
113T cell receptor signaling pathway_Homo sapiens_hsa046600.58774366
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58722443
115FoxO signaling pathway_Homo sapiens_hsa040680.58463111
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58441817
117Tryptophan metabolism_Homo sapiens_hsa003800.58121842
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57979820
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57005370
120Regulation of autophagy_Homo sapiens_hsa041400.56017480
121Glucagon signaling pathway_Homo sapiens_hsa049220.54501654
122ErbB signaling pathway_Homo sapiens_hsa040120.53955255
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53697425
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53631717
125VEGF signaling pathway_Homo sapiens_hsa043700.53310785
126Epstein-Barr virus infection_Homo sapiens_hsa051690.52426998
127mTOR signaling pathway_Homo sapiens_hsa041500.52234506
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.51211972
129MAPK signaling pathway_Homo sapiens_hsa040100.49910459
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49894234
131Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49220598
132N-Glycan biosynthesis_Homo sapiens_hsa005100.48684124
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.48670408
134Sulfur metabolism_Homo sapiens_hsa009200.47096524
135Rap1 signaling pathway_Homo sapiens_hsa040150.47024570
136Prostate cancer_Homo sapiens_hsa052150.46694797
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46629288
138Type II diabetes mellitus_Homo sapiens_hsa049300.45709424
139Chemokine signaling pathway_Homo sapiens_hsa040620.44990314
140HTLV-I infection_Homo sapiens_hsa051660.44937045
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44883754
142Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44316983
143Long-term potentiation_Homo sapiens_hsa047200.44027489
144Glioma_Homo sapiens_hsa052140.41183777

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