TXNL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1formation of translation preinitiation complex (GO:0001731)4.79583978
2folic acid-containing compound biosynthetic process (GO:0009396)4.77986741
3DNA strand elongation involved in DNA replication (GO:0006271)4.53165832
4ribosomal small subunit assembly (GO:0000028)4.36726842
5respiratory chain complex IV assembly (GO:0008535)4.35400829
6proteasome assembly (GO:0043248)4.32065313
7telomere maintenance via semi-conservative replication (GO:0032201)4.31060661
8DNA strand elongation (GO:0022616)4.30618560
9DNA replication initiation (GO:0006270)4.17058942
10nucleobase biosynthetic process (GO:0046112)4.15854111
11DNA double-strand break processing (GO:0000729)4.09524870
12purine nucleobase biosynthetic process (GO:0009113)4.05901685
13protein neddylation (GO:0045116)3.98487909
14DNA unwinding involved in DNA replication (GO:0006268)3.94791271
15DNA deamination (GO:0045006)3.92854070
16maturation of SSU-rRNA (GO:0030490)3.90444222
17protein complex biogenesis (GO:0070271)3.89009451
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.87740311
19establishment of protein localization to mitochondrial membrane (GO:0090151)3.84481456
20telomere maintenance via recombination (GO:0000722)3.83958833
21translational termination (GO:0006415)3.82914480
22viral transcription (GO:0019083)3.81799649
23IMP biosynthetic process (GO:0006188)3.79141868
24cotranslational protein targeting to membrane (GO:0006613)3.78625121
25protein targeting to ER (GO:0045047)3.77272550
26mitochondrial respiratory chain complex I assembly (GO:0032981)3.76403932
27NADH dehydrogenase complex assembly (GO:0010257)3.76403932
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.76403932
29pteridine-containing compound biosynthetic process (GO:0042559)3.73646295
30mitochondrial respiratory chain complex assembly (GO:0033108)3.72607053
31ribosomal large subunit biogenesis (GO:0042273)3.67974936
32folic acid metabolic process (GO:0046655)3.67836649
33DNA replication checkpoint (GO:0000076)3.65670247
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.64552991
35translational initiation (GO:0006413)3.62011914
36protein localization to endoplasmic reticulum (GO:0070972)3.61326318
37translational elongation (GO:0006414)3.60014172
38cytochrome complex assembly (GO:0017004)3.59858522
39deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.57755588
40establishment of protein localization to endoplasmic reticulum (GO:0072599)3.57694761
41mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.56968528
42ribosome biogenesis (GO:0042254)3.53869585
43mitotic recombination (GO:0006312)3.53483332
44lactate metabolic process (GO:0006089)3.50975621
45positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.50808553
46CENP-A containing nucleosome assembly (GO:0034080)3.48628227
47ribosome assembly (GO:0042255)3.47392494
48regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.47029464
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.46617305
50water-soluble vitamin biosynthetic process (GO:0042364)3.46281076
51chromatin remodeling at centromere (GO:0031055)3.43857344
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.43545058
53ribonucleoprotein complex biogenesis (GO:0022613)3.43233684
54regulation of hexokinase activity (GO:1903299)3.40800837
55regulation of glucokinase activity (GO:0033131)3.40800837
56DNA replication-dependent nucleosome organization (GO:0034723)3.40700867
57DNA replication-dependent nucleosome assembly (GO:0006335)3.40700867
58anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.40076357
59IMP metabolic process (GO:0046040)3.38412187
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.37003033
61translation (GO:0006412)3.35438916
62synapsis (GO:0007129)3.33808132
63deoxyribonucleotide biosynthetic process (GO:0009263)3.31171008
64negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.28496102
65negative regulation of ligase activity (GO:0051352)3.28496102
66cullin deneddylation (GO:0010388)3.28176292
67spliceosomal snRNP assembly (GO:0000387)3.28141055
68protein deneddylation (GO:0000338)3.26310089
69telomere maintenance via telomere lengthening (GO:0010833)3.24995912
70regulation of mitotic spindle checkpoint (GO:1903504)3.24570216
71regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.24570216
72nucleotide-excision repair, DNA gap filling (GO:0006297)3.24570107
73deoxyribose phosphate biosynthetic process (GO:0046385)3.24506318
742-deoxyribonucleotide biosynthetic process (GO:0009265)3.24506318
75regulation of cellular amino acid metabolic process (GO:0006521)3.24458853
76mitotic nuclear envelope disassembly (GO:0007077)3.24325129
77pseudouridine synthesis (GO:0001522)3.23462438
78mitotic metaphase plate congression (GO:0007080)3.22386966
79nucleobase-containing small molecule interconversion (GO:0015949)3.17896218
80COPI coating of Golgi vesicle (GO:0048205)3.17891882
81Golgi transport vesicle coating (GO:0048200)3.17891882
82chaperone-mediated protein transport (GO:0072321)3.17654646
83rRNA modification (GO:0000154)3.16585228
84DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.15811997
85nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.14726282
86cell cycle G1/S phase transition (GO:0044843)3.13618940
87G1/S transition of mitotic cell cycle (GO:0000082)3.13618940
88signal peptide processing (GO:0006465)3.13242336
89tetrahydrofolate metabolic process (GO:0046653)3.12624368
90intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.11692409
91signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.11692409
92DNA replication-independent nucleosome assembly (GO:0006336)3.11623436
93DNA replication-independent nucleosome organization (GO:0034724)3.11623436
94ribosomal small subunit biogenesis (GO:0042274)3.10359572
95antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.10306147
96L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.09834390
97positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.09032076
98rRNA processing (GO:0006364)3.08018464
99termination of RNA polymerase III transcription (GO:0006386)3.07424159
100transcription elongation from RNA polymerase III promoter (GO:0006385)3.07424159
101signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.07019034
102signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.07019034
103signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.07019034
104regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.05662033
105viral life cycle (GO:0019058)3.04709950
106pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.03436732
107nuclear envelope disassembly (GO:0051081)3.03423675
108membrane disassembly (GO:0030397)3.03423675
109signal transduction involved in DNA integrity checkpoint (GO:0072401)3.02989128
110signal transduction involved in DNA damage checkpoint (GO:0072422)3.02989128
111regulation of mitochondrial translation (GO:0070129)3.00011363
112DNA damage response, detection of DNA damage (GO:0042769)2.99967117
113ATP synthesis coupled proton transport (GO:0015986)2.99571891
114energy coupled proton transport, down electrochemical gradient (GO:0015985)2.99571891
115positive regulation of ligase activity (GO:0051351)2.98787395
116inositol phosphate catabolic process (GO:0071545)2.98422192
117signal transduction involved in cell cycle checkpoint (GO:0072395)2.96300887
118platelet dense granule organization (GO:0060155)2.95068544
119rRNA metabolic process (GO:0016072)2.94947535
120protein-cofactor linkage (GO:0018065)2.94876366
121cellular protein complex disassembly (GO:0043624)2.93878441
122antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.93705179
123maturation of 5.8S rRNA (GO:0000460)2.93323254
124branched-chain amino acid catabolic process (GO:0009083)2.91021762
125protein targeting to mitochondrion (GO:0006626)2.90576320
126negative regulation of DNA-dependent DNA replication (GO:2000104)2.88215172
127cellular ketone body metabolic process (GO:0046950)2.86119397
128folic acid-containing compound metabolic process (GO:0006760)2.85953401
129somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.85650639
130somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.85650639
131isotype switching (GO:0045190)2.85650639
132pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.84796773
133respiratory electron transport chain (GO:0022904)2.84566144
134transcription-coupled nucleotide-excision repair (GO:0006283)2.84163005
135protein localization to kinetochore (GO:0034501)2.82061600
136cellular component biogenesis (GO:0044085)2.81604078
137metaphase plate congression (GO:0051310)2.81266240
138electron transport chain (GO:0022900)2.80337736
139de novo protein folding (GO:0006458)2.79713559
140protein localization to mitochondrion (GO:0070585)2.78694375
141mannosylation (GO:0097502)2.78602614
142phosphorylated carbohydrate dephosphorylation (GO:0046838)2.77378314
143inositol phosphate dephosphorylation (GO:0046855)2.77378314
144ketone body metabolic process (GO:1902224)2.77158271
145histone exchange (GO:0043486)2.75535603
146nucleoside salvage (GO:0043174)2.75357338
147RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.74415967
148establishment of protein localization to mitochondrion (GO:0072655)2.72309045
149response to pheromone (GO:0019236)2.72113587
150regulation of cilium movement (GO:0003352)2.71988763
151oxidative phosphorylation (GO:0006119)2.67702862
152replication fork processing (GO:0031297)2.67224273
153protein K6-linked ubiquitination (GO:0085020)2.66267083
154somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64991085
155somatic hypermutation of immunoglobulin genes (GO:0016446)2.64991085
156double-strand break repair via nonhomologous end joining (GO:0006303)2.64363464
157non-recombinational repair (GO:0000726)2.64363464
158DNA catabolic process, exonucleolytic (GO:0000738)2.64292921
159regulation of meiosis I (GO:0060631)2.63088469
160peptidyl-histidine modification (GO:0018202)2.62149181
161aldehyde catabolic process (GO:0046185)2.60265965
162polyol catabolic process (GO:0046174)2.58575798
163tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.56890982
164RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.56890982
165histone mRNA metabolic process (GO:0008334)2.56076153
166protein K11-linked ubiquitination (GO:0070979)2.55381105
167amino acid salvage (GO:0043102)2.55259113
168L-methionine salvage (GO:0071267)2.55259113
169L-methionine biosynthetic process (GO:0071265)2.55259113
170organelle disassembly (GO:1903008)2.54190063

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.69093028
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.48678193
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.32913033
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.67095785
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.46046463
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.14672649
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.12950168
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.01982343
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.00766597
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.96189045
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.94958150
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.83720095
13ZNF274_21170338_ChIP-Seq_K562_Hela2.79320660
14* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.70178959
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54977308
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.51445161
17IGF1R_20145208_ChIP-Seq_DFB_Human2.50159132
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47059816
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.46728930
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.41411450
21VDR_22108803_ChIP-Seq_LS180_Human2.38864053
22VDR_23849224_ChIP-Seq_CD4+_Human2.38605441
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.37219966
24XRN2_22483619_ChIP-Seq_HELA_Human2.35897932
25DCP1A_22483619_ChIP-Seq_HELA_Human2.33974315
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33940510
27FOXM1_23109430_ChIP-Seq_U2OS_Human2.32441834
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.22837760
29EWS_26573619_Chip-Seq_HEK293_Human2.18391820
30AR_21909140_ChIP-Seq_LNCAP_Human2.17926636
31ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15596815
32* GABP_19822575_ChIP-Seq_HepG2_Human2.13052631
33FUS_26573619_Chip-Seq_HEK293_Human2.12490476
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11787365
35* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.98939806
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96976808
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.96787318
38FOXP3_21729870_ChIP-Seq_TREG_Human1.94588937
39ELK1_19687146_ChIP-ChIP_HELA_Human1.93881025
40TTF2_22483619_ChIP-Seq_HELA_Human1.88409925
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87866917
42* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83465940
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.80781111
44* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77747558
45P300_19829295_ChIP-Seq_ESCs_Human1.77542115
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.76408677
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75984465
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74487529
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72905429
50GBX2_23144817_ChIP-Seq_PC3_Human1.72063133
51* SRF_21415370_ChIP-Seq_HL-1_Mouse1.71851102
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70936669
53TAF15_26573619_Chip-Seq_HEK293_Human1.64955899
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.63934565
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62036166
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60882331
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59394257
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58053275
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56245190
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55732042
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53107745
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52910973
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52594161
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50289547
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50241827
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41860983
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41737215
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.41308211
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41223939
70ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.40405770
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39482008
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38545376
73KDM5A_27292631_Chip-Seq_BREAST_Human1.38254937
74* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.38175831
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37145360
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37066694
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.36230746
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36071620
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34347825
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32588421
81IRF1_19129219_ChIP-ChIP_H3396_Human1.32106549
82* TFEB_21752829_ChIP-Seq_HELA_Human1.31772911
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.31385473
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30612340
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28085789
86* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27711701
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26334495
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25509929
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25245109
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24618505
91TP53_22573176_ChIP-Seq_HFKS_Human1.23939566
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.23279118
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22894225
94ELK1_22589737_ChIP-Seq_MCF10A_Human1.21713707
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19298472
96HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18262678
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18182661
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17786837
99NANOG_19829295_ChIP-Seq_ESCs_Human1.17775455
100SOX2_19829295_ChIP-Seq_ESCs_Human1.17775455
101STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17636949
102EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17603526
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16715464
104CIITA_25753668_ChIP-Seq_RAJI_Human1.16649225
105ER_23166858_ChIP-Seq_MCF-7_Human1.15502385
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14245740
107* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14239953
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.13838312
109GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13715425
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.13643022
111* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12936502
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11827668
113HTT_18923047_ChIP-ChIP_STHdh_Human1.11519700
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09147164
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08715634
116NOTCH1_21737748_ChIP-Seq_TLL_Human1.07643278
117CRX_20693478_ChIP-Seq_RETINA_Mouse1.07029341
118PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06234986
119POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05081525
120NANOG_18555785_Chip-Seq_ESCs_Mouse1.04576293
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04307952
122SMAD4_21799915_ChIP-Seq_A2780_Human1.04031297
123FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03990183
124TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03292602
125CBP_20019798_ChIP-Seq_JUKART_Human1.03096601
126IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03096601
127CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02749005
128TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02605138
129PIAS1_25552417_ChIP-Seq_VCAP_Human1.02479768
130POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01486768
131EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01442504
132HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00976170
133* SMAD3_21741376_ChIP-Seq_EPCs_Human0.98981854
134* AR_25329375_ChIP-Seq_VCAP_Human0.98444844
135GATA1_22025678_ChIP-Seq_K562_Human0.98040898
136SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97567584
137FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97335722
138FOXA1_25329375_ChIP-Seq_VCAP_Human0.97335722
139P53_22387025_ChIP-Seq_ESCs_Mouse0.97249562
140GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96877945
141MYC_18940864_ChIP-ChIP_HL60_Human0.95873282
142* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95690381
143TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95548309
144STAT3_18555785_Chip-Seq_ESCs_Mouse0.94936977
145MYC_22102868_ChIP-Seq_BL_Human0.94701560
146PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94237256
147NANOG_16153702_ChIP-ChIP_HESCs_Human0.93793985
148SOX17_20123909_ChIP-Seq_XEN_Mouse0.89773946
149* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89642502
150TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89503546
151MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89465619
152ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88581561
153KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88237294
154TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.83883260
155SPI1_23547873_ChIP-Seq_NB4_Human0.82495910
156* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82481872
157CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81219860
158ZNF263_19887448_ChIP-Seq_K562_Human0.80510975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.00055157
2MP0004957_abnormal_blastocyst_morpholog4.21501900
3MP0003806_abnormal_nucleotide_metabolis3.91166271
4MP0010094_abnormal_chromosome_stability3.47915755
5MP0006054_spinal_hemorrhage3.26250783
6MP0003077_abnormal_cell_cycle3.09669242
7MP0003111_abnormal_nucleus_morphology3.00161544
8MP0008057_abnormal_DNA_replication2.71102933
9MP0002102_abnormal_ear_morphology2.57347021
10MP0008058_abnormal_DNA_repair2.52900988
11MP0000372_irregular_coat_pigmentation2.46739290
12MP0003123_paternal_imprinting2.45677345
13MP0002837_dystrophic_cardiac_calcinosis2.44887753
14MP0008932_abnormal_embryonic_tissue2.44617587
15MP0003656_abnormal_erythrocyte_physiolo2.43240856
16MP0003186_abnormal_redox_activity2.41104071
17MP0001529_abnormal_vocalization2.35728842
18MP0006072_abnormal_retinal_apoptosis2.29007618
19MP0002139_abnormal_hepatobiliary_system2.25768194
20MP0008007_abnormal_cellular_replicative2.17145521
21MP0001984_abnormal_olfaction2.10744753
22MP0010352_gastrointestinal_tract_polyps2.07378654
23MP0001730_embryonic_growth_arrest1.97130999
24MP0003880_abnormal_central_pattern1.94370257
25MP0009046_muscle_twitch1.89920277
26MP0004147_increased_porphyrin_level1.88209652
27MP0002638_abnormal_pupillary_reflex1.85791165
28MP0003787_abnormal_imprinting1.82083602
29MP0000350_abnormal_cell_proliferation1.75353142
30MP0004215_abnormal_myocardial_fiber1.73579760
31MP0002396_abnormal_hematopoietic_system1.73334217
32MP0006036_abnormal_mitochondrial_physio1.72240372
33MP0009697_abnormal_copulation1.66819258
34MP0002736_abnormal_nociception_after1.63185654
35MP0008789_abnormal_olfactory_epithelium1.60806129
36MP0005253_abnormal_eye_physiology1.60195374
37MP0005365_abnormal_bile_salt1.58389531
38MP0005551_abnormal_eye_electrophysiolog1.58076273
39MP0009379_abnormal_foot_pigmentation1.56571267
40MP0001697_abnormal_embryo_size1.54419376
41MP0003122_maternal_imprinting1.53072755
42MP0000490_abnormal_crypts_of1.52933870
43MP0000358_abnormal_cell_content/1.48595375
44MP0005220_abnormal_exocrine_pancreas1.46017620
45MP0010307_abnormal_tumor_latency1.43189125
46MP0001485_abnormal_pinna_reflex1.43092526
47MP0003718_maternal_effect1.42569971
48MP0005085_abnormal_gallbladder_physiolo1.41918545
49MP0002080_prenatal_lethality1.40992091
50MP0002090_abnormal_vision1.40121216
51MP0004145_abnormal_muscle_electrophysio1.39818937
52MP0002272_abnormal_nervous_system1.36589997
53MP0002876_abnormal_thyroid_physiology1.34840568
54MP0003786_premature_aging1.34171592
55MP0003195_calcinosis1.32796248
56MP0006276_abnormal_autonomic_nervous1.31437817
57MP0006292_abnormal_olfactory_placode1.29895222
58MP0001968_abnormal_touch/_nociception1.28114536
59MP0005499_abnormal_olfactory_system1.27373457
60MP0005394_taste/olfaction_phenotype1.27373457
61MP0005380_embryogenesis_phenotype1.25866686
62MP0001672_abnormal_embryogenesis/_devel1.25866686
63MP0004133_heterotaxia1.25762896
64MP0001545_abnormal_hematopoietic_system1.25508901
65MP0005397_hematopoietic_system_phenotyp1.25508901
66MP0002877_abnormal_melanocyte_morpholog1.24977309
67MP0000313_abnormal_cell_death1.23940764
68MP0005360_urolithiasis1.23262834
69MP0003984_embryonic_growth_retardation1.21152398
70MP0010030_abnormal_orbit_morphology1.21136672
71MP0003646_muscle_fatigue1.20531059
72MP0005075_abnormal_melanosome_morpholog1.20092641
73MP0000516_abnormal_urinary_system1.18882177
74MP0005367_renal/urinary_system_phenotyp1.18882177
75MP0006035_abnormal_mitochondrial_morpho1.18327662
76MP0002019_abnormal_tumor_incidence1.18289684
77MP0002088_abnormal_embryonic_growth/wei1.18178332
78MP0003221_abnormal_cardiomyocyte_apopto1.16462886
79MP0005646_abnormal_pituitary_gland1.14363053
80MP0009745_abnormal_behavioral_response1.14023647
81MP0001764_abnormal_homeostasis1.13788828
82MP0005645_abnormal_hypothalamus_physiol1.13740541
83MP0005379_endocrine/exocrine_gland_phen1.09529262
84MP0009333_abnormal_splenocyte_physiolog1.09358180
85MP0002086_abnormal_extraembryonic_tissu1.08857503
86MP0010386_abnormal_urinary_bladder1.08728362
87MP0003011_delayed_dark_adaptation1.08222504
88MP0003567_abnormal_fetal_cardiomyocyte1.07892950
89MP0004197_abnormal_fetal_growth/weight/1.06913009
90MP0002234_abnormal_pharynx_morphology1.06625123
91MP0000598_abnormal_liver_morphology1.06434832
92MP0004885_abnormal_endolymph1.05967357
93MP0005319_abnormal_enzyme/_coenzyme1.05932904
94MP0004142_abnormal_muscle_tone1.05568384
95MP0005083_abnormal_biliary_tract1.04281316
96MP0005266_abnormal_metabolism1.04169394
97MP0008995_early_reproductive_senescence1.03605916
98MP0003136_yellow_coat_color1.01782606
99MP0001929_abnormal_gametogenesis1.01158919
100MP0001293_anophthalmia1.00928029
101MP0004808_abnormal_hematopoietic_stem1.00069754
102MP0000631_abnormal_neuroendocrine_gland0.99828335
103MP0002085_abnormal_embryonic_tissue0.99172288
104MP0008872_abnormal_physiological_respon0.98371090
105MP0005636_abnormal_mineral_homeostasis0.96458994
106MP0001188_hyperpigmentation0.95134598
107MP0002084_abnormal_developmental_patter0.94740066
108MP0004043_abnormal_pH_regulation0.93317331
109MP0003890_abnormal_embryonic-extraembry0.92758148
110MP0002751_abnormal_autonomic_nervous0.92226315
111MP0002095_abnormal_skin_pigmentation0.91893965
112MP0005386_behavior/neurological_phenoty0.90959820
113MP0004924_abnormal_behavior0.90959820
114MP0009053_abnormal_anal_canal0.90403790
115MP0000427_abnormal_hair_cycle0.89522978
116MP0004270_analgesia0.89314604
117MP0001905_abnormal_dopamine_level0.89203111
118MP0001486_abnormal_startle_reflex0.89195027
119MP0002734_abnormal_mechanical_nocicepti0.88283244
120MP0003137_abnormal_impulse_conducting0.88105154
121MP0003119_abnormal_digestive_system0.87306353
122MP0009840_abnormal_foam_cell0.86457574
123MP0000858_altered_metastatic_potential0.84086868
124MP0005084_abnormal_gallbladder_morpholo0.83998691
125MP0002163_abnormal_gland_morphology0.83279364
126MP0003698_abnormal_male_reproductive0.81525707
127MP0000647_abnormal_sebaceous_gland0.81299134
128MP0005332_abnormal_amino_acid0.80662007
129MP0001501_abnormal_sleep_pattern0.79792279
130MP0001944_abnormal_pancreas_morphology0.78946307
131MP0005384_cellular_phenotype0.78287299
132MP0008875_abnormal_xenobiotic_pharmacok0.77701115
133MP0002160_abnormal_reproductive_system0.77622286
134MP0005408_hypopigmentation0.77619822
135MP0008877_abnormal_DNA_methylation0.77148409
136MP0000609_abnormal_liver_physiology0.76726181
137MP0000537_abnormal_urethra_morphology0.75031950
138MP0009643_abnormal_urine_homeostasis0.73307392
139MP0005389_reproductive_system_phenotype0.72622513
140MP0005376_homeostasis/metabolism_phenot0.72600601
141MP0003283_abnormal_digestive_organ0.71276153
142MP0001145_abnormal_male_reproductive0.70821859
143MP0009672_abnormal_birth_weight0.70182542
144MP0002938_white_spotting0.70180154
145MP0001915_intracranial_hemorrhage0.69441869
146MP0003121_genomic_imprinting0.69151817
147MP0003315_abnormal_perineum_morphology0.67399268
148MP0001666_abnormal_nutrient_absorption0.66947254
149MP0002210_abnormal_sex_determination0.65106295
150MP0005023_abnormal_wound_healing0.64990281
151MP0004264_abnormal_extraembryonic_tissu0.64903352
152MP0002693_abnormal_pancreas_physiology0.63899362
153MP0003943_abnormal_hepatobiliary_system0.63688761
154MP0005621_abnormal_cell_physiology0.62708665
155MP0002132_abnormal_respiratory_system0.62687373
156MP0003705_abnormal_hypodermis_morpholog0.61752151
157MP0002722_abnormal_immune_system0.61465103
158MP0000653_abnormal_sex_gland0.59750152
159MP0000689_abnormal_spleen_morphology0.59633549
160MP0001243_abnormal_dermal_layer0.59628278
161MP0001119_abnormal_female_reproductive0.59055867
162MP0000477_abnormal_intestine_morphology0.58235149

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.28467213
2Abnormal number of erythroid precursors (HP:0012131)4.16319462
3Abnormality of the heme biosynthetic pathway (HP:0010472)4.11393037
4Aplastic anemia (HP:0001915)3.79906076
5Birth length less than 3rd percentile (HP:0003561)3.72650758
6Degeneration of anterior horn cells (HP:0002398)3.67016620
7Abnormality of the anterior horn cell (HP:0006802)3.67016620
8Oral leukoplakia (HP:0002745)3.34360834
9Methylmalonic acidemia (HP:0002912)3.16273795
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.14436588
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.14436588
12Reticulocytopenia (HP:0001896)3.10328470
13Hypobetalipoproteinemia (HP:0003563)3.01850827
14Hypoglycemic coma (HP:0001325)2.99264948
15Microretrognathia (HP:0000308)2.99054385
16Abnormality of aromatic amino acid family metabolism (HP:0004338)2.97374157
17Hepatic necrosis (HP:0002605)2.92430884
18Macrocytic anemia (HP:0001972)2.87112160
19Colon cancer (HP:0003003)2.85521944
20Medial flaring of the eyebrow (HP:0010747)2.83399575
21Multiple enchondromatosis (HP:0005701)2.78668653
22Increased serum lactate (HP:0002151)2.70281600
23Hepatocellular necrosis (HP:0001404)2.69914867
24Pallor (HP:0000980)2.69410319
25Increased CSF lactate (HP:0002490)2.66278347
26Carpal bone hypoplasia (HP:0001498)2.61567945
27Increased serum pyruvate (HP:0003542)2.59895085
28Abnormality of glycolysis (HP:0004366)2.59895085
29Lipid accumulation in hepatocytes (HP:0006561)2.57659313
30Congenital primary aphakia (HP:0007707)2.56885950
31Gait imbalance (HP:0002141)2.56866563
32Hypothermia (HP:0002045)2.56007502
33Molar tooth sign on MRI (HP:0002419)2.55430624
34Abnormality of midbrain morphology (HP:0002418)2.55430624
35Rough bone trabeculation (HP:0100670)2.52563669
36Mitochondrial inheritance (HP:0001427)2.48748654
373-Methylglutaconic aciduria (HP:0003535)2.48640545
38Pancreatic cysts (HP:0001737)2.47980994
39Breast hypoplasia (HP:0003187)2.47755971
40Poor head control (HP:0002421)2.46118146
41Reduced antithrombin III activity (HP:0001976)2.45801126
42Methylmalonic aciduria (HP:0012120)2.45683659
43Increased hepatocellular lipid droplets (HP:0006565)2.45268948
44Abnormality of the labia minora (HP:0012880)2.45188222
45Hyperbilirubinemia (HP:0002904)2.44939810
46True hermaphroditism (HP:0010459)2.44699574
47Type I transferrin isoform profile (HP:0003642)2.42899024
48Abnormality of monocarboxylic acid metabolism (HP:0010996)2.42626847
49Acute necrotizing encephalopathy (HP:0006965)2.41871025
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41366487
51Abnormality of alanine metabolism (HP:0010916)2.41366487
52Hyperalaninemia (HP:0003348)2.41366487
53Nausea (HP:0002018)2.39880710
54Secondary amenorrhea (HP:0000869)2.37810503
55Nephrogenic diabetes insipidus (HP:0009806)2.37077673
56Progressive muscle weakness (HP:0003323)2.35145739
57Abnormal mitochondria in muscle tissue (HP:0008316)2.34888014
58Generalized aminoaciduria (HP:0002909)2.33073007
59Pancreatic fibrosis (HP:0100732)2.32838924
60Acute encephalopathy (HP:0006846)2.32765602
61Megaloblastic anemia (HP:0001889)2.31950602
62Cerebral hypomyelination (HP:0006808)2.30635997
63Abnormality of reticulocytes (HP:0004312)2.30171128
64Abnormality of pyrimidine metabolism (HP:0004353)2.27584381
65Trismus (HP:0000211)2.25804175
66Lactic acidosis (HP:0003128)2.22050763
67Volvulus (HP:0002580)2.21877296
68Nephronophthisis (HP:0000090)2.20788193
69Hypoglycemic seizures (HP:0002173)2.19274772
70Abnormality of vitamin B metabolism (HP:0004340)2.17041951
71Renal Fanconi syndrome (HP:0001994)2.16941117
72CNS demyelination (HP:0007305)2.15800368
73Aplasia/Hypoplasia of the sacrum (HP:0008517)2.15143925
7411 pairs of ribs (HP:0000878)2.12851581
75Genital tract atresia (HP:0001827)2.12694129
76Abolished electroretinogram (ERG) (HP:0000550)2.11731045
77Atrophy/Degeneration involving motor neurons (HP:0007373)2.11493178
78Ketoacidosis (HP:0001993)2.10406394
79Agnosia (HP:0010524)2.10062024
80Microvesicular hepatic steatosis (HP:0001414)2.09106816
81Abnormality of methionine metabolism (HP:0010901)2.09073661
82Cerebral edema (HP:0002181)2.08703675
83Neoplasm of the pancreas (HP:0002894)2.07258276
84Abnormality of the fovea (HP:0000493)2.06339602
85Abnormality of glycine metabolism (HP:0010895)2.06143665
86Abnormality of serine family amino acid metabolism (HP:0010894)2.06143665
87Vaginal atresia (HP:0000148)2.05657210
88Abnormal protein glycosylation (HP:0012346)2.05585645
89Abnormal glycosylation (HP:0012345)2.05585645
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05585645
91Abnormal protein N-linked glycosylation (HP:0012347)2.05585645
92Abnormality of the intrinsic pathway (HP:0010989)2.05005806
93Abnormality of aspartate family amino acid metabolism (HP:0010899)2.02193005
94Spastic diplegia (HP:0001264)2.00439732
95Tongue fasciculations (HP:0001308)2.00219358
96Selective tooth agenesis (HP:0001592)1.99864108
97Increased serum ferritin (HP:0003281)1.99657640
98Increased intramyocellular lipid droplets (HP:0012240)1.98952860
99Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97348991
100Angiofibromas (HP:0010615)1.97021338
101Adenoma sebaceum (HP:0009720)1.97021338
102Intestinal atresia (HP:0011100)1.96367931
103Hyperglycinuria (HP:0003108)1.96351036
104Optic disc pallor (HP:0000543)1.95285790
105Abnormality of serum amino acid levels (HP:0003112)1.94180123
106Premature graying of hair (HP:0002216)1.93161158
107Hypoplasia of the fovea (HP:0007750)1.92614265
108Aplasia/Hypoplasia of the fovea (HP:0008060)1.92614265
109Neoplasm of the adrenal gland (HP:0100631)1.92372604
110Abnormality of transition element cation homeostasis (HP:0011030)1.91104483
111Glossoptosis (HP:0000162)1.90872950
112Postnatal microcephaly (HP:0005484)1.90533519
113Thrombocytosis (HP:0001894)1.89380234
114Abnormality of iron homeostasis (HP:0011031)1.89033154
115Renal cortical cysts (HP:0000803)1.89014080
116Ependymoma (HP:0002888)1.88966267
117Increased muscle lipid content (HP:0009058)1.88535244
118Pancytopenia (HP:0001876)1.88111510
119Abnormality of the vitamin B12 metabolism (HP:0004341)1.87957437
120Abnormal hemoglobin (HP:0011902)1.87173583
121Abnormal trabecular bone morphology (HP:0100671)1.86304210
122Short middle phalanx of the 5th finger (HP:0004220)1.85813732
123Exercise intolerance (HP:0003546)1.85109274
124Reticulocytosis (HP:0001923)1.85082622
125Abnormality of urine glucose concentration (HP:0011016)1.83529613
126Glycosuria (HP:0003076)1.83529613
127Pancreatic islet-cell hyperplasia (HP:0004510)1.82697977
128Exertional dyspnea (HP:0002875)1.82164491
129Acanthocytosis (HP:0001927)1.81961512
130Hyperglycinemia (HP:0002154)1.81414909
131Intrahepatic cholestasis (HP:0001406)1.81159186
132Hyperinsulinemic hypoglycemia (HP:0000825)1.80503104
133Lethargy (HP:0001254)1.80458278
134Muscular hypotonia of the trunk (HP:0008936)1.80075542
135Gonadotropin excess (HP:0000837)1.79476535
136Progressive macrocephaly (HP:0004481)1.78281870
137Abnormality of macular pigmentation (HP:0008002)1.77757787
138Respiratory failure (HP:0002878)1.77515066
139Poikilocytosis (HP:0004447)1.77157250
140Muscle fibrillation (HP:0010546)1.76627208
141Premature ovarian failure (HP:0008209)1.76257527
142Congenital stationary night blindness (HP:0007642)1.76162240
143Aplasia/hypoplasia of the uterus (HP:0008684)1.74699972
144Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.73790102
145Broad-based gait (HP:0002136)1.73410959
146Male pseudohermaphroditism (HP:0000037)1.71433858
147Abnormality of the renal medulla (HP:0100957)1.70390570
148Leukodystrophy (HP:0002415)1.69995872
149Abnormal lung lobation (HP:0002101)1.64979869
150Abnormality of the renal cortex (HP:0011035)1.64757063
151Abnormality of the pancreatic islet cells (HP:0006476)1.64299198
152Abnormality of endocrine pancreas physiology (HP:0012093)1.64299198
153Decreased electroretinogram (ERG) amplitude (HP:0000654)1.62515917
154Type II lissencephaly (HP:0007260)1.61834360
155Abnormality of chromosome stability (HP:0003220)1.60428825
156Supernumerary spleens (HP:0009799)1.60341758

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.22218142
2EIF2AK14.08089237
3NME23.56361840
4BUB13.54777001
5CDC73.10637072
6TRIM282.97729625
7ACVR1B2.84434201
8BRSK22.81741679
9EIF2AK32.79316883
10SCYL22.73408553
11MAP4K22.64282495
12NEK12.58031360
13WNK32.57271171
14NUAK12.44817597
15PASK2.42447651
16STK162.14593953
17BCKDK2.13563287
18RPS6KA41.93858760
19ERBB31.92626522
20VRK11.90297638
21FLT31.83108279
22CASK1.81817543
23TLK11.74375138
24TGFBR11.74032332
25PBK1.71311979
26SRPK11.69573065
27TNIK1.68482571
28NEK21.67545138
29TSSK61.64816688
30TESK21.63537831
31VRK21.60846145
32PLK11.60244029
33PIM21.57676325
34MAP3K121.56109204
35MAP3K41.50107687
36PLK21.44720311
37GRK11.41423223
38BRSK11.41235192
39RPS6KB21.40636900
40PINK11.40557591
41CSNK1G21.39581944
42DYRK31.38739856
43CSNK1G31.38520500
44INSRR1.37048359
45CSNK1G11.35026722
46TTK1.34199683
47MAP3K111.34086193
48KDR1.33845650
49AURKB1.31324512
50MAP2K71.18222665
51CDK71.17681007
52PLK41.17498880
53PLK31.16922225
54AURKA1.15043771
55MAP3K81.12762597
56MKNK11.11809180
57CSNK1A1L1.10995176
58ATR1.10402521
59TESK11.09735220
60PDK21.04215432
61MAPK131.03628021
62CCNB11.01232613
63PHKG11.00649613
64PHKG21.00649613
65OBSCN1.00582791
66CDK80.99704738
67PAK30.98177416
68NEK90.97369890
69CHEK20.96475531
70EPHA20.95946233
71EPHA40.95764185
72ADRBK20.92026436
73BRAF0.87335363
74ABL20.86419390
75STK38L0.83091881
76OXSR10.82187360
77NME10.82114824
78LIMK10.78728835
79TIE10.78539585
80CDK40.77006972
81SIK30.75766506
82CSNK2A10.74506170
83PRKCE0.72810004
84PNCK0.72163526
85PAK40.70766083
86CSNK2A20.70521945
87TAF10.70158352
88ERN10.69575815
89PKN20.68863694
90STK100.65550883
91PRKCG0.64892497
92MINK10.63535248
93ZAK0.62912443
94STK390.62440698
95MAPKAPK30.62008925
96MAP3K50.61471082
97CHEK10.61281718
98LRRK20.59759413
99MAP3K30.58607816
100DAPK10.57548971
101MARK10.56617948
102MKNK20.55990899
103FER0.55834025
104EIF2AK20.55750335
105ARAF0.52376298
106PIM10.52287441
107STK40.51313460
108MAP2K30.51219266
109ATM0.50398674
110BMPR1B0.49565473
111ZAP700.49458421
112DAPK20.48397645
113PAK10.46145487
114CDK20.45197294
115CDK190.44675429
116CAMK2A0.42242099
117MELK0.41273455
118MAP2K20.40664506
119CSNK1A10.39884024
120CDK60.39779221
121STK240.39601631
122TAOK20.38960364
123FGFR20.37904911
124PIK3CG0.37250462
125CAMK2D0.37123033
126FRK0.35955458
127MST40.35909658
128RPS6KA50.35680286
129NLK0.35525969
130ILK0.35019429
131MUSK0.34645297
132TBK10.33828983
133JAK30.33825087
134CSNK1E0.33578430
135PRKCI0.31853078
136TRIB30.31777619
137DYRK20.31392456
138BLK0.30412748
139TEC0.30092745
140MYLK0.29832108
141CSNK1D0.29659671
142PRKACA0.29215155
143CDK10.28454319
144CAMKK20.27411059
145ADRBK10.26918490
146CDK30.26497539
147STK30.25998491
148ERBB40.25539371
149MAPK110.25160565
150DYRK1B0.23810264
151TYK20.23532664
152BCR0.22562303
153PDK30.22411670
154PDK40.22411670
155PAK20.21762259
156IRAK30.21725336
157MET0.21533552

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.35110108
2Proteasome_Homo sapiens_hsa030503.95497740
3Mismatch repair_Homo sapiens_hsa034303.52407224
4Ribosome_Homo sapiens_hsa030103.48168182
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.02308856
6Protein export_Homo sapiens_hsa030602.73065883
7One carbon pool by folate_Homo sapiens_hsa006702.65931841
8RNA polymerase_Homo sapiens_hsa030202.63462911
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.57545943
10Spliceosome_Homo sapiens_hsa030402.54470066
11RNA transport_Homo sapiens_hsa030132.52990094
12Pyrimidine metabolism_Homo sapiens_hsa002402.47768961
13Nucleotide excision repair_Homo sapiens_hsa034202.36586314
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.27275834
15Base excision repair_Homo sapiens_hsa034102.25378642
16Folate biosynthesis_Homo sapiens_hsa007902.14248549
17Homologous recombination_Homo sapiens_hsa034402.08167581
18Fatty acid elongation_Homo sapiens_hsa000622.06958142
19Butanoate metabolism_Homo sapiens_hsa006501.99672680
20Cell cycle_Homo sapiens_hsa041101.92415668
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83008722
22Selenocompound metabolism_Homo sapiens_hsa004501.66300056
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.56500471
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53362953
25Sulfur relay system_Homo sapiens_hsa041221.49768557
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.44768516
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.42186675
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.37709474
29Collecting duct acid secretion_Homo sapiens_hsa049661.37690833
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.36956991
31RNA degradation_Homo sapiens_hsa030181.35132559
32Basal transcription factors_Homo sapiens_hsa030221.34812003
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.33482435
34Phototransduction_Homo sapiens_hsa047441.31718935
35Steroid biosynthesis_Homo sapiens_hsa001001.24792499
36Non-homologous end-joining_Homo sapiens_hsa034501.23578052
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22115418
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20606992
39Biosynthesis of amino acids_Homo sapiens_hsa012301.20424771
40Parkinsons disease_Homo sapiens_hsa050121.19125096
41p53 signaling pathway_Homo sapiens_hsa041151.18138873
42Pentose phosphate pathway_Homo sapiens_hsa000301.15595648
43Purine metabolism_Homo sapiens_hsa002301.15581738
44Carbon metabolism_Homo sapiens_hsa012001.11756483
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08781264
46Oxidative phosphorylation_Homo sapiens_hsa001901.07269310
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02656707
48Fanconi anemia pathway_Homo sapiens_hsa034601.02396346
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99781179
50Galactose metabolism_Homo sapiens_hsa000520.94929685
51Cardiac muscle contraction_Homo sapiens_hsa042600.94405154
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93661483
53N-Glycan biosynthesis_Homo sapiens_hsa005100.91215791
54Huntingtons disease_Homo sapiens_hsa050160.90432776
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90341113
56Legionellosis_Homo sapiens_hsa051340.89220040
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89021533
58Glutathione metabolism_Homo sapiens_hsa004800.88017925
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87202448
60Epstein-Barr virus infection_Homo sapiens_hsa051690.85666763
61Systemic lupus erythematosus_Homo sapiens_hsa053220.83427831
62Fatty acid metabolism_Homo sapiens_hsa012120.83125809
63Nitrogen metabolism_Homo sapiens_hsa009100.81841080
64Nicotine addiction_Homo sapiens_hsa050330.81579848
65mRNA surveillance pathway_Homo sapiens_hsa030150.76875980
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76294633
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75334200
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74718100
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69004390
70Pyruvate metabolism_Homo sapiens_hsa006200.65650984
71Fructose and mannose metabolism_Homo sapiens_hsa000510.65373229
72Circadian rhythm_Homo sapiens_hsa047100.65207473
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64974755
74Antigen processing and presentation_Homo sapiens_hsa046120.60989638
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.60302011
76Sulfur metabolism_Homo sapiens_hsa009200.60083222
77Thyroid cancer_Homo sapiens_hsa052160.59789520
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.58914751
79Metabolic pathways_Homo sapiens_hsa011000.56535051
80Caffeine metabolism_Homo sapiens_hsa002320.56502090
81Viral carcinogenesis_Homo sapiens_hsa052030.54691363
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54388536
83Herpes simplex infection_Homo sapiens_hsa051680.54031772
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53727261
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52933836
86Synaptic vesicle cycle_Homo sapiens_hsa047210.51349713
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50427268
88Peroxisome_Homo sapiens_hsa041460.48432576
89Taste transduction_Homo sapiens_hsa047420.47504128
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46839425
91Insulin secretion_Homo sapiens_hsa049110.46703082
92Tryptophan metabolism_Homo sapiens_hsa003800.46113988
93Arginine and proline metabolism_Homo sapiens_hsa003300.44458237
94Alzheimers disease_Homo sapiens_hsa050100.43471263
95Oocyte meiosis_Homo sapiens_hsa041140.42811836
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42570632
97Fatty acid degradation_Homo sapiens_hsa000710.41865574
98Ether lipid metabolism_Homo sapiens_hsa005650.41368513
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.40615834
100Linoleic acid metabolism_Homo sapiens_hsa005910.39003769
101Vitamin B6 metabolism_Homo sapiens_hsa007500.38235743
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37902351
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36905199
104Olfactory transduction_Homo sapiens_hsa047400.36791778
105Starch and sucrose metabolism_Homo sapiens_hsa005000.36345020
106Retinol metabolism_Homo sapiens_hsa008300.36007637
107GABAergic synapse_Homo sapiens_hsa047270.33242878
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32996733
109Propanoate metabolism_Homo sapiens_hsa006400.32909637
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32570328
111Bladder cancer_Homo sapiens_hsa052190.30007153
112Renin-angiotensin system_Homo sapiens_hsa046140.29489919
113Phenylalanine metabolism_Homo sapiens_hsa003600.25489932
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22702853
115Fat digestion and absorption_Homo sapiens_hsa049750.22005639
116Tyrosine metabolism_Homo sapiens_hsa003500.21499551
117Chemical carcinogenesis_Homo sapiens_hsa052040.21328766
118beta-Alanine metabolism_Homo sapiens_hsa004100.20160225
119Apoptosis_Homo sapiens_hsa042100.19727231
120HTLV-I infection_Homo sapiens_hsa051660.19343992
121Shigellosis_Homo sapiens_hsa051310.19167466
122Arginine biosynthesis_Homo sapiens_hsa002200.18017715
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17904938
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16264011
125Regulation of autophagy_Homo sapiens_hsa041400.15417086
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.14102684
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.12986901

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