TXNL4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the U5 small ribonucleoprotein particle (snRNP), and is involved in pre-mRNA splicing. This protein contains a thioredoxin-like fold and it is expected to interact with multiple proteins. Protein-protein interactions have been observed with the polyglutamine tract-binding protein 1 (PQBP1). Mutations in both the coding region and promoter region of this gene have been associated with Burn-McKeown syndrome, which is a rare disorder characterized by craniofacial dysmorphisms, cardiac defects, hearing loss, and bilateral choanal atresia. A pseudogene of this gene is found on chromosome 2. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.20877153
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.95550793
3ATP synthesis coupled proton transport (GO:0015986)5.95550793
4DNA deamination (GO:0045006)5.72786310
5chaperone-mediated protein transport (GO:0072321)5.52737594
6establishment of protein localization to mitochondrial membrane (GO:0090151)5.48080434
7ribosomal small subunit assembly (GO:0000028)5.44540500
8maturation of SSU-rRNA (GO:0030490)4.82521095
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.76769127
10respiratory electron transport chain (GO:0022904)4.75297674
11electron transport chain (GO:0022900)4.67561223
12proteasome assembly (GO:0043248)4.64458465
13protein targeting to membrane (GO:0006612)4.54994503
14protein complex biogenesis (GO:0070271)4.50172085
15telomere maintenance via semi-conservative replication (GO:0032201)4.49902764
16DNA strand elongation involved in DNA replication (GO:0006271)4.49212212
17viral transcription (GO:0019083)4.48971488
18ribosomal large subunit biogenesis (GO:0042273)4.48409253
19translational termination (GO:0006415)4.45352097
20pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.37624271
21ribosomal small subunit biogenesis (GO:0042274)4.33230334
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.31894955
23mitochondrial respiratory chain complex I assembly (GO:0032981)4.31894955
24NADH dehydrogenase complex assembly (GO:0010257)4.31894955
25mitochondrial respiratory chain complex assembly (GO:0033108)4.27588830
26DNA strand elongation (GO:0022616)4.25811183
27formation of translation preinitiation complex (GO:0001731)4.17295627
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.16892401
29nucleobase biosynthetic process (GO:0046112)4.11777979
30ribonucleoprotein complex biogenesis (GO:0022613)4.08795874
31purine nucleobase biosynthetic process (GO:0009113)4.07922527
32translational elongation (GO:0006414)4.07921875
33nuclear-transcribed mRNA catabolic process (GO:0000956)4.07860006
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.01307852
35DNA replication initiation (GO:0006270)4.00444050
36transcription elongation from RNA polymerase III promoter (GO:0006385)3.99417682
37termination of RNA polymerase III transcription (GO:0006386)3.99417682
38spliceosomal snRNP assembly (GO:0000387)3.99352551
39deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.98953436
40GTP biosynthetic process (GO:0006183)3.97880283
41positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.97087410
42telomere maintenance via recombination (GO:0000722)3.96540830
43regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.95454551
44ribosome biogenesis (GO:0042254)3.93700771
45cotranslational protein targeting to membrane (GO:0006613)3.90779960
46anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.90234194
47translational initiation (GO:0006413)3.89655243
48protein targeting to ER (GO:0045047)3.88266406
49mRNA catabolic process (GO:0006402)3.87673117
50DNA replication checkpoint (GO:0000076)3.86975625
51UTP biosynthetic process (GO:0006228)3.84218415
52pyrimidine nucleotide catabolic process (GO:0006244)3.80621239
53protein neddylation (GO:0045116)3.77384543
54negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.77019875
55negative regulation of ligase activity (GO:0051352)3.77019875
56rRNA modification (GO:0000154)3.76782905
57substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.75509044
58substrate-independent telencephalic tangential migration (GO:0021826)3.75509044
59CENP-A containing nucleosome assembly (GO:0034080)3.75185751
60rRNA processing (GO:0006364)3.72394045
61behavioral response to nicotine (GO:0035095)3.72149744
62protein localization to endoplasmic reticulum (GO:0070972)3.70024016
63transcription-coupled nucleotide-excision repair (GO:0006283)3.69051771
64mitotic recombination (GO:0006312)3.68655436
65pseudouridine synthesis (GO:0001522)3.68608468
66protein targeting to mitochondrion (GO:0006626)3.68474084
67chromatin remodeling at centromere (GO:0031055)3.67743652
687-methylguanosine mRNA capping (GO:0006370)3.67260142
69establishment of protein localization to endoplasmic reticulum (GO:0072599)3.66181751
70translation (GO:0006412)3.64863089
71establishment of protein localization to mitochondrion (GO:0072655)3.64463370
72UTP metabolic process (GO:0046051)3.61664534
73RNA catabolic process (GO:0006401)3.60834734
74ribosome assembly (GO:0042255)3.59549046
75telomere maintenance via telomere lengthening (GO:0010833)3.59293082
76nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.59280711
77DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.59171058
78purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.58721489
79rRNA metabolic process (GO:0016072)3.58339526
807-methylguanosine RNA capping (GO:0009452)3.57810214
81RNA capping (GO:0036260)3.57810214
82cullin deneddylation (GO:0010388)3.56834486
83purine nucleoside triphosphate biosynthetic process (GO:0009145)3.54924604
84cellular protein complex disassembly (GO:0043624)3.54688420
85viral life cycle (GO:0019058)3.54018923
86signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.53175089
87signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.53175089
88signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.53175089
89protein deneddylation (GO:0000338)3.52885153
90intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.52754736
91signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.52754736
92positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.50110835
93mitotic metaphase plate congression (GO:0007080)3.49636347
94regulation of cellular amino acid metabolic process (GO:0006521)3.49529788
95signal transduction involved in DNA damage checkpoint (GO:0072422)3.46623017
96signal transduction involved in DNA integrity checkpoint (GO:0072401)3.46623017
97ATP biosynthetic process (GO:0006754)3.46355554
98pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.44201176
99signal transduction involved in cell cycle checkpoint (GO:0072395)3.44000546
100L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.43500748
101cellular component biogenesis (GO:0044085)3.43467214
102protein localization to mitochondrion (GO:0070585)3.39310032
103viral mRNA export from host cell nucleus (GO:0046784)3.38605075
104regulation of mitochondrial translation (GO:0070129)3.38097469
105ribonucleoside triphosphate biosynthetic process (GO:0009201)3.37310932
106positive regulation of ligase activity (GO:0051351)3.34356583
107nucleotide-excision repair, DNA gap filling (GO:0006297)3.34342984
108antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.33810575
109pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.31879010
110kinetochore assembly (GO:0051382)3.30049034
111transcription from RNA polymerase I promoter (GO:0006360)3.29521939
112hydrogen ion transmembrane transport (GO:1902600)3.27701196
113protein targeting (GO:0006605)3.24518167
114CTP biosynthetic process (GO:0006241)3.23977951
115CTP metabolic process (GO:0046036)3.23977951
116exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.23655652
117* spliceosomal complex assembly (GO:0000245)3.23440775
118DNA replication-independent nucleosome organization (GO:0034724)3.21784418
119DNA replication-independent nucleosome assembly (GO:0006336)3.21784418
120kinetochore organization (GO:0051383)3.20662273
121establishment of protein localization to membrane (GO:0090150)3.20452556
122deoxyribonucleotide biosynthetic process (GO:0009263)3.20139714
123termination of RNA polymerase I transcription (GO:0006363)3.19628210
124guanosine-containing compound biosynthetic process (GO:1901070)3.18822231
125pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.18216731
126DNA unwinding involved in DNA replication (GO:0006268)3.18054131
127establishment of integrated proviral latency (GO:0075713)3.17714847
128G1/S transition of mitotic cell cycle (GO:0000082)3.17513309
129cell cycle G1/S phase transition (GO:0044843)3.17513309
130protein complex disassembly (GO:0043241)3.15318110
131transcription elongation from RNA polymerase I promoter (GO:0006362)3.13602700
132antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.12862493
133nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.12065687
134regulation of ubiquitin-protein transferase activity (GO:0051438)3.09917871
135macromolecular complex disassembly (GO:0032984)3.05929802
136nucleobase-containing small molecule interconversion (GO:0015949)3.05520239
137pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.05071856
138establishment of protein localization to organelle (GO:0072594)3.04013111
139metaphase plate congression (GO:0051310)3.03969413
140deoxyribose phosphate biosynthetic process (GO:0046385)3.00080307
1412-deoxyribonucleotide biosynthetic process (GO:0009265)3.00080307
142pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.98450714
143regulation of ligase activity (GO:0051340)2.98437514
144histone exchange (GO:0043486)2.98091371
145nucleoside triphosphate biosynthetic process (GO:0009142)2.94975574
146base-excision repair, AP site formation (GO:0006285)2.92909543
147peptidyl-histidine modification (GO:0018202)2.91997778
148mitochondrial transport (GO:0006839)2.91120240
149intracellular protein transmembrane import (GO:0044743)2.87892583
150oxidative phosphorylation (GO:0006119)2.81698684
151respiratory chain complex IV assembly (GO:0008535)2.78783974
152ncRNA 3-end processing (GO:0043628)2.78608442
153cytochrome complex assembly (GO:0017004)2.74449536
154proton transport (GO:0015992)2.72224546
155negative regulation of organelle assembly (GO:1902116)2.69204771
156water-soluble vitamin biosynthetic process (GO:0042364)2.67453395
157inner mitochondrial membrane organization (GO:0007007)2.67428696
158hydrogen transport (GO:0006818)2.65582128
159protein localization to membrane (GO:0072657)2.63473056
160heterochromatin organization (GO:0070828)2.61513248
161ncRNA processing (GO:0034470)2.60761908
162metallo-sulfur cluster assembly (GO:0031163)2.60573508
163iron-sulfur cluster assembly (GO:0016226)2.60573508
164establishment of mitochondrion localization (GO:0051654)2.59558798

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.37976392
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.57064397
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.11803742
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.98581073
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.68859173
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.65634153
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.61242674
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.40024450
9MYC_18358816_ChIP-ChIP_MESCs_Mouse3.20921392
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.13037800
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.08638886
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.03275230
13MYC_19030024_ChIP-ChIP_MESCs_Mouse3.02008785
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.99990638
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.99091611
16EZH2_22144423_ChIP-Seq_EOC_Human2.97109475
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.73924914
18VDR_23849224_ChIP-Seq_CD4+_Human2.56034810
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.55932666
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.54084447
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.53318544
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.53045701
23XRN2_22483619_ChIP-Seq_HELA_Human2.51323996
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40701125
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.38602930
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.38355194
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.31466022
28* DCP1A_22483619_ChIP-Seq_HELA_Human2.22477789
29GABP_19822575_ChIP-Seq_HepG2_Human2.14246339
30FOXP3_21729870_ChIP-Seq_TREG_Human2.14185289
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.13486525
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.13310185
33YY1_21170310_ChIP-Seq_MESCs_Mouse2.00796530
34TTF2_22483619_ChIP-Seq_HELA_Human1.99053194
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.97316781
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94112411
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91782349
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88570889
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84429143
40* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83416946
41ELK1_19687146_ChIP-ChIP_HELA_Human1.82847407
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81275349
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80809618
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76431958
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75443185
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72583837
47* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68989105
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67731299
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66089160
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64441531
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.59692048
52* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59594020
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59175914
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58070219
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55241361
56CIITA_25753668_ChIP-Seq_RAJI_Human1.55215221
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.52478837
58* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.50710040
59AR_21909140_ChIP-Seq_LNCAP_Human1.48121124
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41606805
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41503871
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41465109
63CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40249516
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39073671
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.38038979
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37844548
67* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36571982
68KDM5A_27292631_Chip-Seq_BREAST_Human1.33320946
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.33158317
70FOXP1_21924763_ChIP-Seq_HESCs_Human1.31886390
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.28625403
72CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.26970971
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.26824646
74IRF1_19129219_ChIP-ChIP_H3396_Human1.21231413
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17714212
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13975357
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11890880
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.11327425
79P68_20966046_ChIP-Seq_HELA_Human1.11262400
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10970708
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10374334
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10050279
83* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09841465
84EZH2_27304074_Chip-Seq_ESCs_Mouse1.09624010
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09250852
86CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09151297
87MYC_18940864_ChIP-ChIP_HL60_Human1.07711156
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07461516
89TFEB_21752829_ChIP-Seq_HELA_Human1.06953523
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06927934
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05825702
92SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03492076
93* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02887830
94BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02394354
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02096779
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01941832
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00830461
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00349992
99VDR_21846776_ChIP-Seq_THP-1_Human0.98840797
100* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98351591
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98334425
102HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97634980
103ZNF263_19887448_ChIP-Seq_K562_Human0.97263174
104* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95577677
105SPI1_23547873_ChIP-Seq_NB4_Human0.95540198
106JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93444103
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93318495
108CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92221573
109TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91782265
110YY1_22570637_ChIP-Seq_MALME-3M_Human0.91655224
111TP63_19390658_ChIP-ChIP_HaCaT_Human0.91604844
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90848263
113TP53_20018659_ChIP-ChIP_R1E_Mouse0.90694412
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.90110902
115REST_21632747_ChIP-Seq_MESCs_Mouse0.89064704
116EZH2_27294783_Chip-Seq_ESCs_Mouse0.88937749
117REST_18959480_ChIP-ChIP_MESCs_Mouse0.88692118
118ELF1_20517297_ChIP-Seq_JURKAT_Human0.88052437
119ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87694663
120CTCF_27219007_Chip-Seq_Bcells_Human0.86945599
121MYC_22102868_ChIP-Seq_BL_Human0.86511368
122CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85824100
123PHF8_20622854_ChIP-Seq_HELA_Human0.84856882
124EED_16625203_ChIP-ChIP_MESCs_Mouse0.84578589
125OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82421392
126SRY_22984422_ChIP-ChIP_TESTIS_Rat0.82261429
127SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81437728
128* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81208417
129SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.80915264
130* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.79732426
131DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78020895
132SOX17_20123909_ChIP-Seq_XEN_Mouse0.75497088
133* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74718291
134CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.72417686

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.86647129
2MP0004957_abnormal_blastocyst_morpholog4.69526489
3MP0003111_abnormal_nucleus_morphology4.31789960
4MP0010094_abnormal_chromosome_stability4.31533177
5MP0003077_abnormal_cell_cycle3.97795965
6MP0008058_abnormal_DNA_repair3.80604575
7MP0008007_abnormal_cellular_replicative3.42851764
8MP0008932_abnormal_embryonic_tissue2.89899131
9MP0008057_abnormal_DNA_replication2.81088043
10MP0003786_premature_aging2.58370133
11MP0003123_paternal_imprinting2.57175792
12MP0009379_abnormal_foot_pigmentation2.56272340
13MP0002822_catalepsy2.36404470
14MP0002163_abnormal_gland_morphology2.30316788
15MP0003718_maternal_effect2.22363116
16MP0003186_abnormal_redox_activity2.05916558
17MP0008877_abnormal_DNA_methylation2.04231833
18MP0002396_abnormal_hematopoietic_system2.02539855
19MP0005423_abnormal_somatic_nervous2.01772308
20MP0003787_abnormal_imprinting2.01138948
21MP0005394_taste/olfaction_phenotype1.99601897
22MP0005499_abnormal_olfactory_system1.99601897
23MP0001730_embryonic_growth_arrest1.94107322
24MP0003806_abnormal_nucleotide_metabolis1.94026765
25MP0000350_abnormal_cell_proliferation1.89226841
26MP0003880_abnormal_central_pattern1.88921090
27MP0000490_abnormal_crypts_of1.88206450
28MP0000778_abnormal_nervous_system1.87323498
29MP0004142_abnormal_muscle_tone1.86478954
30MP0003122_maternal_imprinting1.76311852
31MP0006276_abnormal_autonomic_nervous1.73227554
32MP0003315_abnormal_perineum_morphology1.66558805
33MP0010030_abnormal_orbit_morphology1.65708948
34MP0002653_abnormal_ependyma_morphology1.55303677
35MP0000313_abnormal_cell_death1.51321401
36MP0006292_abnormal_olfactory_placode1.48981013
37MP0006036_abnormal_mitochondrial_physio1.48556114
38MP0001905_abnormal_dopamine_level1.48518733
39MP0000955_abnormal_spinal_cord1.48252441
40MP0004133_heterotaxia1.47833084
41MP0009333_abnormal_splenocyte_physiolog1.47060844
42MP0001697_abnormal_embryo_size1.46734676
43MP0002234_abnormal_pharynx_morphology1.45973691
44MP0000631_abnormal_neuroendocrine_gland1.38700735
45MP0009053_abnormal_anal_canal1.38129544
46MP0002080_prenatal_lethality1.38120359
47MP0002272_abnormal_nervous_system1.36770591
48MP0005645_abnormal_hypothalamus_physiol1.35664146
49MP0006035_abnormal_mitochondrial_morpho1.35135240
50MP0001672_abnormal_embryogenesis/_devel1.33695455
51MP0005380_embryogenesis_phenotype1.33695455
52MP0003136_yellow_coat_color1.33557904
53MP0002184_abnormal_innervation1.32752811
54MP0002019_abnormal_tumor_incidence1.32428226
55MP0004859_abnormal_synaptic_plasticity1.29731821
56MP0003635_abnormal_synaptic_transmissio1.29441146
57MP0000358_abnormal_cell_content/1.29393950
58MP0005646_abnormal_pituitary_gland1.27156896
59MP0002733_abnormal_thermal_nociception1.26278431
60MP0002132_abnormal_respiratory_system1.25723291
61MP0002160_abnormal_reproductive_system1.24373009
62MP0010352_gastrointestinal_tract_polyps1.24049356
63MP0005379_endocrine/exocrine_gland_phen1.23780186
64MP0004808_abnormal_hematopoietic_stem1.21732274
65MP0002210_abnormal_sex_determination1.21413432
66MP0003283_abnormal_digestive_organ1.20691724
67MP0003984_embryonic_growth_retardation1.19231832
68MP0002557_abnormal_social/conspecific_i1.16811435
69MP0002736_abnormal_nociception_after1.16352989
70MP0002638_abnormal_pupillary_reflex1.16141925
71MP0003763_abnormal_thymus_physiology1.16109680
72MP0001853_heart_inflammation1.15290424
73MP0002088_abnormal_embryonic_growth/wei1.15170749
74MP0001970_abnormal_pain_threshold1.14800757
75MP0003385_abnormal_body_wall1.14722977
76MP0002085_abnormal_embryonic_tissue1.13041736
77MP0009046_muscle_twitch1.11765118
78MP0002752_abnormal_somatic_nervous1.11271287
79MP0002734_abnormal_mechanical_nocicepti1.10838078
80MP0009745_abnormal_behavioral_response1.10523916
81MP0003942_abnormal_urinary_system1.09534525
82MP0006072_abnormal_retinal_apoptosis1.09135046
83MP0002063_abnormal_learning/memory/cond1.09073402
84MP0000858_altered_metastatic_potential1.09053728
85MP0003861_abnormal_nervous_system1.08743279
86MP0005389_reproductive_system_phenotype1.08058061
87MP0002837_dystrophic_cardiac_calcinosis1.07680280
88MP0001145_abnormal_male_reproductive1.06449688
89MP0003941_abnormal_skin_development1.04921393
90MP0001293_anophthalmia1.04889292
91MP0002572_abnormal_emotion/affect_behav1.03314789
92MP0001968_abnormal_touch/_nociception1.03300281
93MP0002882_abnormal_neuron_morphology1.02728794
94MP0005397_hematopoietic_system_phenotyp1.02324787
95MP0001545_abnormal_hematopoietic_system1.02324787
96MP0005075_abnormal_melanosome_morpholog1.01196485
97MP0002722_abnormal_immune_system0.99548648
98MP0002152_abnormal_brain_morphology0.99301754
99MP0001727_abnormal_embryo_implantation0.99106301
100MP0003567_abnormal_fetal_cardiomyocyte0.97138703
101MP0002064_seizures0.96538803
102MP0002398_abnormal_bone_marrow0.96235811
103MP0003121_genomic_imprinting0.95620864
104MP0005195_abnormal_posterior_eye0.95509322
105MP0000689_abnormal_spleen_morphology0.94330682
106MP0004742_abnormal_vestibular_system0.94204566
107MP0004145_abnormal_muscle_electrophysio0.94147756
108MP0000703_abnormal_thymus_morphology0.94051834
109MP0005551_abnormal_eye_electrophysiolog0.91364714
110MP0004811_abnormal_neuron_physiology0.91231523
111MP0001929_abnormal_gametogenesis0.88861183
112MP0000653_abnormal_sex_gland0.88859028
113MP0001919_abnormal_reproductive_system0.88197438
114MP0002084_abnormal_developmental_patter0.87949590
115MP0003938_abnormal_ear_development0.87867793
116MP0006054_spinal_hemorrhage0.87581204
117MP0002067_abnormal_sensory_capabilities0.87150932
118MP0001119_abnormal_female_reproductive0.86851320
119MP0001440_abnormal_grooming_behavior0.85960939
120MP0002095_abnormal_skin_pigmentation0.85774870
121MP0009785_altered_susceptibility_to0.85669128
122MP0001286_abnormal_eye_development0.85110153
123MP0002429_abnormal_blood_cell0.83513734
124MP0001984_abnormal_olfaction0.83353250
125MP0002086_abnormal_extraembryonic_tissu0.83073745
126MP0003937_abnormal_limbs/digits/tail_de0.81912365
127MP0001764_abnormal_homeostasis0.81828322
128MP0002102_abnormal_ear_morphology0.81390271
129MP0001485_abnormal_pinna_reflex0.81186880
130MP0003011_delayed_dark_adaptation0.80915069
131MP0009250_abnormal_appendicular_skeleto0.79646067
132MP0000026_abnormal_inner_ear0.79644506
133MP0004197_abnormal_fetal_growth/weight/0.78085049
134MP0010307_abnormal_tumor_latency0.78055461
135MP0005084_abnormal_gallbladder_morpholo0.77166125
136MP0002233_abnormal_nose_morphology0.76815601
137MP0004885_abnormal_endolymph0.76245912
138MP0005174_abnormal_tail_pigmentation0.76168682
139MP0005384_cellular_phenotype0.75725477
140MP0003119_abnormal_digestive_system0.73452744
141MP0000015_abnormal_ear_pigmentation0.73438730
142MP0002697_abnormal_eye_size0.73231170
143MP0002751_abnormal_autonomic_nervous0.72633492
144MP0001835_abnormal_antigen_presentation0.71012955
145MP0002938_white_spotting0.70746520
146MP0000716_abnormal_immune_system0.69301952
147MP0001986_abnormal_taste_sensitivity0.69132222
148MP0000537_abnormal_urethra_morphology0.68376813
149MP0000750_abnormal_muscle_regeneration0.67586104
150MP0005671_abnormal_response_to0.67429136
151MP0000049_abnormal_middle_ear0.66046853
152MP0001188_hyperpigmentation0.62934112
153MP0002111_abnormal_tail_morphology0.61288660
154MP0001529_abnormal_vocalization0.61254316
155MP0002277_abnormal_respiratory_mucosa0.61164329
156MP0003890_abnormal_embryonic-extraembry0.59619698
157MP0000678_abnormal_parathyroid_gland0.59168330
158MP0000372_irregular_coat_pigmentation0.57570335
159MP0004147_increased_porphyrin_level0.57378492
160MP0002148_abnormal_hypersensitivity_rea0.56869988
161MP0009672_abnormal_birth_weight0.55984431
162MP0008789_abnormal_olfactory_epithelium0.55977999
163MP0008260_abnormal_autophagy0.54741805
164MP0000566_synostosis0.54716500
165MP0002420_abnormal_adaptive_immunity0.54173610
166MP0001819_abnormal_immune_cell0.53814592
167MP0009697_abnormal_copulation0.53802388

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.77108160
2Abnormality of cells of the erythroid lineage (HP:0012130)4.74379053
3Abnormal number of erythroid precursors (HP:0012131)4.68096690
4Birth length less than 3rd percentile (HP:0003561)4.24277131
5Oral leukoplakia (HP:0002745)3.94087697
6Increased intramyocellular lipid droplets (HP:0012240)3.89864349
7Abnormality of the anterior horn cell (HP:0006802)3.83877257
8Degeneration of anterior horn cells (HP:0002398)3.83877257
9Aplastic anemia (HP:0001915)3.83653396
10Breast hypoplasia (HP:0003187)3.73659455
11Renal Fanconi syndrome (HP:0001994)3.64556236
12Hepatocellular necrosis (HP:0001404)3.63590561
13Rough bone trabeculation (HP:0100670)3.57276967
14Macrocytic anemia (HP:0001972)3.56768226
15Myokymia (HP:0002411)3.55028598
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.47587477
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.47587477
18Carpal bone hypoplasia (HP:0001498)3.44617348
19Cerebral edema (HP:0002181)3.43383787
20Mitochondrial inheritance (HP:0001427)3.42761527
21Increased muscle lipid content (HP:0009058)3.42740653
22Colon cancer (HP:0003003)3.39351100
23Cerebral hypomyelination (HP:0006808)3.30556275
24Acute necrotizing encephalopathy (HP:0006965)3.30183175
25Increased CSF lactate (HP:0002490)3.28533251
26Increased serum lactate (HP:0002151)3.27435602
27Hepatic necrosis (HP:0002605)3.19522053
28Patellar aplasia (HP:0006443)3.08949948
29Pallor (HP:0000980)3.04522216
30Abnormal mitochondria in muscle tissue (HP:0008316)3.01904329
31Microretrognathia (HP:0000308)2.99114016
32Aplasia/Hypoplasia of the patella (HP:0006498)2.98053348
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.96451895
34Type I transferrin isoform profile (HP:0003642)2.96133296
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.93867388
363-Methylglutaconic aciduria (HP:0003535)2.92387213
37Microvesicular hepatic steatosis (HP:0001414)2.85371589
38Optic disc pallor (HP:0000543)2.83360707
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.82680283
40Abnormal trabecular bone morphology (HP:0100671)2.79200417
41Poor head control (HP:0002421)2.78184931
42Increased hepatocellular lipid droplets (HP:0006565)2.76559568
43Trismus (HP:0000211)2.76391130
44Premature graying of hair (HP:0002216)2.74721301
45Absent thumb (HP:0009777)2.68417621
46Abnormal number of incisors (HP:0011064)2.67536894
47Acute encephalopathy (HP:0006846)2.61750897
48Progressive macrocephaly (HP:0004481)2.60636411
49Meckel diverticulum (HP:0002245)2.58962510
5011 pairs of ribs (HP:0000878)2.57531896
51Leukodystrophy (HP:0002415)2.56284740
52Chromsome breakage (HP:0040012)2.54827087
53Selective tooth agenesis (HP:0001592)2.53675193
54Abnormality of the preputium (HP:0100587)2.53302962
55Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47417768
56Absent rod-and cone-mediated responses on ERG (HP:0007688)2.46011361
57Rib fusion (HP:0000902)2.44399341
58Abnormality of the ileum (HP:0001549)2.43175371
59Atrophy/Degeneration involving motor neurons (HP:0007373)2.41248477
60Exercise intolerance (HP:0003546)2.39679478
61Lactic acidosis (HP:0003128)2.39624724
62Abnormality of glycolysis (HP:0004366)2.39255920
63Increased serum pyruvate (HP:0003542)2.39255920
64Cleft eyelid (HP:0000625)2.38842978
65Multiple enchondromatosis (HP:0005701)2.38785264
66Thrombocytosis (HP:0001894)2.38547336
67Hyperglycinemia (HP:0002154)2.37829349
68Lipid accumulation in hepatocytes (HP:0006561)2.36141050
69Neoplasm of the pancreas (HP:0002894)2.35569870
70Cellular immunodeficiency (HP:0005374)2.33686665
71Down-sloping shoulders (HP:0200021)2.31439229
72Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.30987153
73Molar tooth sign on MRI (HP:0002419)2.30854666
74Abnormality of midbrain morphology (HP:0002418)2.30854666
75Exertional dyspnea (HP:0002875)2.30247792
76Pancytopenia (HP:0001876)2.29197589
77Muscle fiber atrophy (HP:0100295)2.25315664
78Secondary amenorrhea (HP:0000869)2.25247216
79Bone marrow hypocellularity (HP:0005528)2.24608364
80Pendular nystagmus (HP:0012043)2.23088542
81Respiratory failure (HP:0002878)2.20315987
82Premature ovarian failure (HP:0008209)2.20256586
83Sparse eyelashes (HP:0000653)2.18755767
84Agnosia (HP:0010524)2.18141457
85Horseshoe kidney (HP:0000085)2.16444464
86Type 2 muscle fiber atrophy (HP:0003554)2.15840533
87Triphalangeal thumb (HP:0001199)2.14727900
88Abnormality of renal resorption (HP:0011038)2.14277309
89Absent radius (HP:0003974)2.13958436
90Pancreatic fibrosis (HP:0100732)2.13622928
91Progressive cerebellar ataxia (HP:0002073)2.13406427
92Depressed nasal ridge (HP:0000457)2.11161460
93Aplasia/hypoplasia of the uterus (HP:0008684)2.06580372
94Abnormality of chromosome stability (HP:0003220)2.05848404
95Medulloblastoma (HP:0002885)2.04507686
96Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03562760
97Abnormal protein N-linked glycosylation (HP:0012347)2.03562760
98Abnormal protein glycosylation (HP:0012346)2.03562760
99Abnormal glycosylation (HP:0012345)2.03562760
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02719713
101Abnormality of alanine metabolism (HP:0010916)2.02719713
102Hyperalaninemia (HP:0003348)2.02719713
103Aplasia/Hypoplasia of the uvula (HP:0010293)2.02318946
104Maternal diabetes (HP:0009800)2.02066757
105CNS demyelination (HP:0007305)2.01390449
106Abnormal lung lobation (HP:0002101)1.99926615
107Unsteady gait (HP:0002317)1.99152444
108Progressive muscle weakness (HP:0003323)1.98021536
109Aplasia involving forearm bones (HP:0009822)1.97453266
110Absent forearm bone (HP:0003953)1.97453266
111Emotional lability (HP:0000712)1.96672819
112CNS hypomyelination (HP:0003429)1.96365818
113Respiratory difficulties (HP:0002880)1.96303688
114Abnormality of reticulocytes (HP:0004312)1.94640643
115Hyperthyroidism (HP:0000836)1.94301764
116Myelodysplasia (HP:0002863)1.93305424
117Reduced antithrombin III activity (HP:0001976)1.93086376
118Hypoplasia of the radius (HP:0002984)1.91158291
119Abnormality of the labia minora (HP:0012880)1.90941626
120Megaloblastic anemia (HP:0001889)1.89856742
121Tracheoesophageal fistula (HP:0002575)1.88700473
122Impulsivity (HP:0100710)1.88466186
123Septo-optic dysplasia (HP:0100842)1.88252494
124Sclerocornea (HP:0000647)1.87885151
125Deep palmar crease (HP:0006191)1.87858306
126Medial flaring of the eyebrow (HP:0010747)1.87787063
127Glossoptosis (HP:0000162)1.87650801
128Lethargy (HP:0001254)1.85631786
129Gait imbalance (HP:0002141)1.85341270
130X-linked dominant inheritance (HP:0001423)1.83688725
131Hyperphosphaturia (HP:0003109)1.82916875
132Anencephaly (HP:0002323)1.78273801
133Abnormality of urine glucose concentration (HP:0011016)1.77563589
134Glycosuria (HP:0003076)1.77563589
135Poor suck (HP:0002033)1.77091128
136Pancreatic cysts (HP:0001737)1.70840456
137Abnormal rod and cone electroretinograms (HP:0008323)1.70627651
138Type II lissencephaly (HP:0007260)1.69812080
139Congenital primary aphakia (HP:0007707)1.68894811
140Thick lower lip vermilion (HP:0000179)1.68237700
141Nephrogenic diabetes insipidus (HP:0009806)1.66306571
142Concave nail (HP:0001598)1.62921921
143Anophthalmia (HP:0000528)1.61358642
144Elevated erythrocyte sedimentation rate (HP:0003565)1.61084949
145True hermaphroditism (HP:0010459)1.60584201
146Shawl scrotum (HP:0000049)1.60457054
147Failure to thrive in infancy (HP:0001531)1.60384674
148Agitation (HP:0000713)1.60270126
149Partial duplication of thumb phalanx (HP:0009944)1.57586454
150Confusion (HP:0001289)1.55423028
151Testicular atrophy (HP:0000029)1.54796222
152High anterior hairline (HP:0009890)1.53767460
153Dysphonia (HP:0001618)1.53464988
154Lissencephaly (HP:0001339)1.53035955
155Optic nerve coloboma (HP:0000588)1.52650877

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.09781551
2WEE14.07758924
3EIF2AK13.97719169
4STK163.22487190
5SRPK13.07495197
6VRK23.05780110
7NME22.97814327
8TLK12.79797976
9PLK42.79492567
10EPHB22.72920295
11CDC72.56259070
12VRK12.39658208
13TSSK62.20255482
14ACVR1B2.17058337
15EIF2AK32.15949348
16TESK22.10569798
17BRSK21.80681848
18ZAK1.73381766
19PLK11.70234037
20MAP3K111.66393086
21NEK11.66000214
22NEK21.65911348
23IRAK31.63837655
24TTK1.57202198
25PIM21.56492748
26PBK1.53423116
27RPS6KA41.52694704
28DYRK31.43541825
29MKNK11.41680307
30WNK41.39773069
31AURKA1.37542005
32BRSK11.36254089
33AURKB1.35921549
34KDR1.32375274
35MAP3K41.31357957
36NME11.28654190
37TESK11.28265037
38CDK71.28240708
39PLK31.27903118
40CDK81.25498062
41ATR1.23548314
42CCNB11.18029948
43MAP2K71.15265719
44EPHA21.12874480
45TYRO31.12389673
46BRAF1.05638487
47EIF2AK21.04452605
48TAOK21.03940267
49CHEK21.03138673
50DMPK1.03029178
51ADRBK21.02747745
52MKNK21.02496454
53IRAK41.01939080
54PASK1.00162100
55RPS6KB20.97899136
56BCKDK0.95308630
57MAP3K90.94859721
58PRKD30.93341587
59CAMK1D0.93068573
60MINK10.92449520
61MAP2K20.91308471
62PAK40.87979417
63MAP3K80.87909722
64DYRK20.87744279
65CSNK1G20.83903421
66MARK10.82624317
67TGFBR10.82545402
68TRIB30.82456243
69CSNK1G30.80425942
70PRKCG0.80299834
71PNCK0.79906564
72WNK30.79764301
73SCYL20.77882539
74PKN10.77249733
75CSNK1E0.76656543
76CSNK2A10.76533727
77TAF10.75088085
78GRK10.74181426
79LIMK10.73146087
80MAP3K120.71204816
81BLK0.68908026
82NTRK20.68148143
83CSNK2A20.68139758
84CHEK10.67127797
85CDK190.66472828
86DYRK1B0.64621371
87CAMK1G0.63777483
88PAK10.63621120
89ABL20.63344227
90PRKCI0.61614070
91STK110.60040645
92RPS6KA50.59483233
93CAMKK10.56853047
94CAMK10.56728507
95BMPR1B0.55085885
96SIK20.54535313
97TEC0.54516905
98PIM10.54469014
99MAP4K10.54245242
100CDK11A0.53518478
101STK40.53392135
102CASK0.52999486
103CDK40.52789104
104CSNK1A1L0.52583516
105ILK0.51371270
106STK100.51321631
107CDK140.51242194
108MAP2K60.50472256
109ALK0.49358727
110STK38L0.49311805
111PAK60.48450656
112ICK0.48090342
113CDK20.47907348
114YES10.47766398
115ATM0.46058393
116RPS6KA60.45691975
117SIK30.44123764
118PHKG20.43968091
119PHKG10.43968091
120CSNK1G10.43781475
121MAPKAPK30.43550925
122FLT30.43207293
123CDK150.43084980
124MAPKAPK50.42419513
125MAP3K30.42170171
126AKT10.41944799
127TXK0.41724160
128RPS6KA20.39895136
129SMG10.38108266
130ARAF0.37019772
131DAPK30.36197701
132MAP2K30.36193583
133MYLK0.35982079
134TYK20.35878505
135IKBKB0.33545578
136LRRK20.32424035
137PINK10.32317245
138CDK10.31773596
139DAPK10.30356510
140STK240.26364424
141BTK0.24903098
142ZAP700.23273385
143AKT20.22447839
144NLK0.22444081
145IRAK20.20042716
146MST40.19200072
147AKT30.17877701

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.51986159
2DNA replication_Homo sapiens_hsa030304.50225361
3Ribosome_Homo sapiens_hsa030104.46304873
4RNA polymerase_Homo sapiens_hsa030203.93157039
5Mismatch repair_Homo sapiens_hsa034303.81493780
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.42492590
7* Spliceosome_Homo sapiens_hsa030403.08308824
8Homologous recombination_Homo sapiens_hsa034402.88943686
9Base excision repair_Homo sapiens_hsa034102.87648271
10Pyrimidine metabolism_Homo sapiens_hsa002402.84718440
11Nucleotide excision repair_Homo sapiens_hsa034202.80889054
12RNA transport_Homo sapiens_hsa030132.62624855
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.20048091
14One carbon pool by folate_Homo sapiens_hsa006702.19508521
15Fanconi anemia pathway_Homo sapiens_hsa034602.02473868
16Cell cycle_Homo sapiens_hsa041102.01913693
17Basal transcription factors_Homo sapiens_hsa030221.80948281
18Oxidative phosphorylation_Homo sapiens_hsa001901.79011333
19Parkinsons disease_Homo sapiens_hsa050121.78712785
20Protein export_Homo sapiens_hsa030601.77407070
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75389707
22RNA degradation_Homo sapiens_hsa030181.74082877
23Purine metabolism_Homo sapiens_hsa002301.55388634
24Huntingtons disease_Homo sapiens_hsa050161.53912213
25Non-homologous end-joining_Homo sapiens_hsa034501.47509681
26Folate biosynthesis_Homo sapiens_hsa007901.36276532
27p53 signaling pathway_Homo sapiens_hsa041151.26857158
28Epstein-Barr virus infection_Homo sapiens_hsa051691.17699036
29Sulfur relay system_Homo sapiens_hsa041221.15429730
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14030055
31mRNA surveillance pathway_Homo sapiens_hsa030151.11323348
32Nicotine addiction_Homo sapiens_hsa050330.97983935
33Phototransduction_Homo sapiens_hsa047440.95301240
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92901696
35Alzheimers disease_Homo sapiens_hsa050100.90405019
36Cysteine and methionine metabolism_Homo sapiens_hsa002700.88496008
37Pyruvate metabolism_Homo sapiens_hsa006200.87471000
38Pentose phosphate pathway_Homo sapiens_hsa000300.85436330
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80742258
40Systemic lupus erythematosus_Homo sapiens_hsa053220.79622952
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78455561
42Collecting duct acid secretion_Homo sapiens_hsa049660.76768219
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74523865
44Synaptic vesicle cycle_Homo sapiens_hsa047210.73637279
45Herpes simplex infection_Homo sapiens_hsa051680.70350956
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.69995200
47Basal cell carcinoma_Homo sapiens_hsa052170.69728461
48Peroxisome_Homo sapiens_hsa041460.68892589
49Glutathione metabolism_Homo sapiens_hsa004800.68468164
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67966577
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64504825
52Antigen processing and presentation_Homo sapiens_hsa046120.63872975
53Selenocompound metabolism_Homo sapiens_hsa004500.62882198
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60105122
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59943798
56Legionellosis_Homo sapiens_hsa051340.59623590
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.57912973
58Biosynthesis of amino acids_Homo sapiens_hsa012300.57090143
59Oocyte meiosis_Homo sapiens_hsa041140.55322158
60Hedgehog signaling pathway_Homo sapiens_hsa043400.53813031
61Viral carcinogenesis_Homo sapiens_hsa052030.50874582
62Fructose and mannose metabolism_Homo sapiens_hsa000510.48527496
63N-Glycan biosynthesis_Homo sapiens_hsa005100.48404278
64Galactose metabolism_Homo sapiens_hsa000520.47484277
65Morphine addiction_Homo sapiens_hsa050320.47000660
66Phenylalanine metabolism_Homo sapiens_hsa003600.46281987
67Metabolic pathways_Homo sapiens_hsa011000.46038950
68HTLV-I infection_Homo sapiens_hsa051660.43985593
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43752825
70Cocaine addiction_Homo sapiens_hsa050300.43116274
71Carbon metabolism_Homo sapiens_hsa012000.42213352
72Arachidonic acid metabolism_Homo sapiens_hsa005900.41287544
73Vitamin B6 metabolism_Homo sapiens_hsa007500.41261796
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40510139
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39581038
76Thyroid cancer_Homo sapiens_hsa052160.37838459
77Axon guidance_Homo sapiens_hsa043600.37647656
78Primary immunodeficiency_Homo sapiens_hsa053400.37360855
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34796868
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34744875
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34728408
82Steroid biosynthesis_Homo sapiens_hsa001000.34091533
83Shigellosis_Homo sapiens_hsa051310.33461481
84Measles_Homo sapiens_hsa051620.33353216
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33184516
86Propanoate metabolism_Homo sapiens_hsa006400.32674754
87Cardiac muscle contraction_Homo sapiens_hsa042600.30071063
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29755844
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28991063
90Sulfur metabolism_Homo sapiens_hsa009200.27934056
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27924483
92Apoptosis_Homo sapiens_hsa042100.26778424
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26690408
94Regulation of autophagy_Homo sapiens_hsa041400.25730954
95Glutamatergic synapse_Homo sapiens_hsa047240.25708122
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25661445
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25438785
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24754479
99Tryptophan metabolism_Homo sapiens_hsa003800.24106603
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22934700
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22691609
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22208721
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.20887397
104GABAergic synapse_Homo sapiens_hsa047270.20759164
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20738104
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.20497522
107Tyrosine metabolism_Homo sapiens_hsa003500.20108498
108Influenza A_Homo sapiens_hsa051640.19936509
109Wnt signaling pathway_Homo sapiens_hsa043100.19306876
110Allograft rejection_Homo sapiens_hsa053300.19283881
111Cholinergic synapse_Homo sapiens_hsa047250.19210020
112Dopaminergic synapse_Homo sapiens_hsa047280.18861802
113Fatty acid elongation_Homo sapiens_hsa000620.18746939
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18432490
115beta-Alanine metabolism_Homo sapiens_hsa004100.18404118
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18179761
117Fat digestion and absorption_Homo sapiens_hsa049750.17863017
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17567494
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.17387674
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.17198715
121Notch signaling pathway_Homo sapiens_hsa043300.16947546
122Melanoma_Homo sapiens_hsa052180.16939966
123Hematopoietic cell lineage_Homo sapiens_hsa046400.16178257
124Other glycan degradation_Homo sapiens_hsa005110.15924184
125Alcoholism_Homo sapiens_hsa050340.15396019
126Renin-angiotensin system_Homo sapiens_hsa046140.15122091
127Graft-versus-host disease_Homo sapiens_hsa053320.14808706
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14444490
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14325141
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.12922331
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.12730185
132HIF-1 signaling pathway_Homo sapiens_hsa040660.12218519
133Hepatitis B_Homo sapiens_hsa051610.12148533
134Pentose and glucuronate interconversions_Homo sapiens_hsa000400.11309567
135Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.10578194
136Nitrogen metabolism_Homo sapiens_hsa009100.10572533
137Asthma_Homo sapiens_hsa053100.10039885
138Small cell lung cancer_Homo sapiens_hsa052220.08901048
139Vibrio cholerae infection_Homo sapiens_hsa051100.07391779
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.07297431
141TGF-beta signaling pathway_Homo sapiens_hsa043500.06162043
142Type I diabetes mellitus_Homo sapiens_hsa049400.06114666
143Hippo signaling pathway_Homo sapiens_hsa043900.04449422
144Arginine and proline metabolism_Homo sapiens_hsa003300.03804859

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