TXNP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ATP synthesis coupled proton transport (GO:0015986)5.75837368
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.75837368
3chaperone-mediated protein transport (GO:0072321)5.36814015
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.30985129
5respiratory chain complex IV assembly (GO:0008535)5.30210718
6DNA deamination (GO:0045006)4.97815204
7regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.89098621
8ribosomal small subunit biogenesis (GO:0042274)4.85811384
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.81084707
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.52548183
11transcription elongation from RNA polymerase III promoter (GO:0006385)4.29250534
12termination of RNA polymerase III transcription (GO:0006386)4.29250534
13respiratory electron transport chain (GO:0022904)4.26727068
14electron transport chain (GO:0022900)4.24186123
15cytochrome complex assembly (GO:0017004)4.21922224
16maturation of SSU-rRNA (GO:0030490)4.17489998
17deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.09423726
18mitochondrial respiratory chain complex I assembly (GO:0032981)4.07500029
19NADH dehydrogenase complex assembly (GO:0010257)4.07500029
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.07500029
21regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.03420719
22positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.03420719
23pseudouridine synthesis (GO:0001522)3.93865097
24protein complex biogenesis (GO:0070271)3.89354591
25purine-containing compound salvage (GO:0043101)3.84757192
26regulation of vitamin D biosynthetic process (GO:0060556)3.73741097
27S-adenosylmethionine metabolic process (GO:0046500)3.72216882
28protein neddylation (GO:0045116)3.69167717
29mitochondrial respiratory chain complex assembly (GO:0033108)3.68432224
30ribosomal large subunit biogenesis (GO:0042273)3.66604340
31negative regulation of heart rate (GO:0010459)3.62193115
32inner mitochondrial membrane organization (GO:0007007)3.60889327
33proteasome assembly (GO:0043248)3.56574387
34peptidyl-histidine modification (GO:0018202)3.53286910
35rRNA modification (GO:0000154)3.51428201
36viral transcription (GO:0019083)3.50976324
37translational termination (GO:0006415)3.49391904
38regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.47814033
39negative regulation of metanephros development (GO:0072217)3.46412508
40protein targeting to mitochondrion (GO:0006626)3.44964983
41translation (GO:0006412)3.43656916
42regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.41235540
43regulation of cellular amino acid metabolic process (GO:0006521)3.38504540
44SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.36417835
45translational elongation (GO:0006414)3.34996237
46protein localization to mitochondrion (GO:0070585)3.34801338
47production of molecular mediator involved in inflammatory response (GO:0002532)3.34603882
48regulation of cytokine production involved in inflammatory response (GO:1900015)3.34287167
49GMP metabolic process (GO:0046037)3.31203449
50rRNA processing (GO:0006364)3.31037105
51protein-cofactor linkage (GO:0018065)3.30548304
52cotranslational protein targeting to membrane (GO:0006613)3.28029381
53regulation of interleukin-6 biosynthetic process (GO:0045408)3.26973688
54ATP biosynthetic process (GO:0006754)3.25320677
55protein homotrimerization (GO:0070207)3.24827316
56protein targeting to ER (GO:0045047)3.24596376
57purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.21802863
58rRNA metabolic process (GO:0016072)3.20957813
59water-soluble vitamin biosynthetic process (GO:0042364)3.17032890
60purine nucleoside triphosphate biosynthetic process (GO:0009145)3.16889004
61regulation of podosome assembly (GO:0071801)3.16805862
62establishment of protein localization to mitochondrion (GO:0072655)3.14622560
63purine nucleotide salvage (GO:0032261)3.12021921
64negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.10946707
65GTP biosynthetic process (GO:0006183)3.10663119
66modulation of growth of symbiont involved in interaction with host (GO:0044144)3.09892987
67regulation of growth of symbiont in host (GO:0044126)3.09892987
68negative regulation of growth of symbiont in host (GO:0044130)3.09892987
69negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.09892987
70guanosine-containing compound biosynthetic process (GO:1901070)3.09040559
71positive regulation of chemokine biosynthetic process (GO:0045080)3.08953578
72establishment of protein localization to endoplasmic reticulum (GO:0072599)3.08738701
73nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.06318649
74cytidine deamination (GO:0009972)3.05354378
75cytidine metabolic process (GO:0046087)3.05354378
76cytidine catabolic process (GO:0006216)3.05354378
77protein localization to endoplasmic reticulum (GO:0070972)3.05309136
78exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.02841406
79DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.02261954
80xenobiotic catabolic process (GO:0042178)3.02166158
81IMP biosynthetic process (GO:0006188)3.02068676
82protein deneddylation (GO:0000338)3.01753540
83pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.01597193
84activated T cell proliferation (GO:0050798)3.01552726
85signal peptide processing (GO:0006465)2.96016818
86cellular component biogenesis (GO:0044085)2.95180361
87ribonucleoprotein complex biogenesis (GO:0022613)2.94198822
88positive regulation of prostaglandin secretion (GO:0032308)2.93930737
89signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.93418739
90intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.93418739
91signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.92609339
92signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.92609339
93signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.92609339
94hydrogen ion transmembrane transport (GO:1902600)2.91238188
95negative regulation of ligase activity (GO:0051352)2.91116304
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.91116304
97regulation of vitamin metabolic process (GO:0030656)2.90480522
98ribosomal small subunit assembly (GO:0000028)2.87779732
99cullin deneddylation (GO:0010388)2.84281373
100regulation of interleukin-12 biosynthetic process (GO:0045075)2.81909458

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat8.84160275
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.42750165
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.35587483
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.61158097
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.59991519
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.56370207
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.53663356
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.33413487
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.95987840
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.83031627
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.79437043
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72408380
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.66410152
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.58729664
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.55247819
16VDR_23849224_ChIP-Seq_CD4+_Human2.53577225
17DCP1A_22483619_ChIP-Seq_HELA_Human2.45362768
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44325832
19FOXP3_21729870_ChIP-Seq_TREG_Human2.31765090
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26338965
21VDR_22108803_ChIP-Seq_LS180_Human2.14601698
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.04791509
23ELK1_19687146_ChIP-ChIP_HELA_Human2.00632052
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99775049
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95206482
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.91545310
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84957968
28GABP_19822575_ChIP-Seq_HepG2_Human1.73670486
29IRF1_19129219_ChIP-ChIP_H3396_Human1.68728246
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67079588
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61764259
32POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.58568593
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.57627223
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57360414
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.57252388
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56624879
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.52535153
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48366510
39E2F7_22180533_ChIP-Seq_HELA_Human1.47082444
40CIITA_25753668_ChIP-Seq_RAJI_Human1.45367686
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45359467
42ELK1_22589737_ChIP-Seq_MCF10A_Human1.42386287
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.42084218
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42029856
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.40752779
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36810117
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.35215114
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34983154
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31507136
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31452267
51MYC_18940864_ChIP-ChIP_HL60_Human1.30594941
52ZNF274_21170338_ChIP-Seq_K562_Hela1.28142918
53TTF2_22483619_ChIP-Seq_HELA_Human1.27156429
54HTT_18923047_ChIP-ChIP_STHdh_Human1.25883882
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25729634
56CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.24850408
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24180670
58TP53_22573176_ChIP-Seq_HFKS_Human1.21352851
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20786054
60EWS_26573619_Chip-Seq_HEK293_Human1.19200751
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17585439
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.17477393
63XRN2_22483619_ChIP-Seq_HELA_Human1.16741927
64IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10530024
65BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04709107
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04372262
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00470304
68EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99919998
69PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98473951
70FUS_26573619_Chip-Seq_HEK293_Human0.97316576
71GATA3_26560356_Chip-Seq_TH2_Human0.95105550
72FOXA1_25329375_ChIP-Seq_VCAP_Human0.92658851
73FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92658851
74TAF2_19829295_ChIP-Seq_ESCs_Human0.91126368
75FOXH1_21741376_ChIP-Seq_EPCs_Human0.89478506
76AR_20517297_ChIP-Seq_VCAP_Human0.89014779
77PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88570918
78EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87684201
79ERG_20517297_ChIP-Seq_VCAP_Human0.87587223
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86528812
81CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86101499
82NCOR_22424771_ChIP-Seq_293T_Human0.82547821
83RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.80457384
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79938585
85AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79391528
86ELF5_23300383_ChIP-Seq_T47D_Human0.77395145
87SOX2_19829295_ChIP-Seq_ESCs_Human0.77203316
88NANOG_19829295_ChIP-Seq_ESCs_Human0.77203316
89ERG_20887958_ChIP-Seq_HPC-7_Mouse0.75987238
90FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75303138
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.74652909
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.72975455
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.71786497
94SPI1_20517297_ChIP-Seq_HL60_Human0.71451618
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71207957
96EGR1_19032775_ChIP-ChIP_M12_Human0.70375564
97SUZ12_27294783_Chip-Seq_NPCs_Mouse0.68697139
98PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.67674654
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.67403836
100BMI1_23680149_ChIP-Seq_NPCS_Mouse0.66807143

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.29505164
2MP0005671_abnormal_response_to4.17719399
3MP0000372_irregular_coat_pigmentation3.87315540
4MP0001873_stomach_inflammation3.66713463
5MP0009785_altered_susceptibility_to3.49816085
6MP0009333_abnormal_splenocyte_physiolog2.97713305
7MP0003806_abnormal_nucleotide_metabolis2.69773471
8MP0003186_abnormal_redox_activity2.35616876
9MP0009379_abnormal_foot_pigmentation2.31084032
10MP0000685_abnormal_immune_system2.30697471
11MP0002148_abnormal_hypersensitivity_rea2.27277017
12MP0003880_abnormal_central_pattern2.25928718
13MP0003436_decreased_susceptibility_to2.17458250
14MP0005408_hypopigmentation2.13893565
15MP0008875_abnormal_xenobiotic_pharmacok2.10521658
16MP0002876_abnormal_thyroid_physiology2.01016212
17MP0000015_abnormal_ear_pigmentation2.00652069
18MP0003195_calcinosis1.98290180
19MP0005000_abnormal_immune_tolerance1.82851132
20MP0001790_abnormal_immune_system1.80910993
21MP0005387_immune_system_phenotype1.80910993
22MP0006036_abnormal_mitochondrial_physio1.77328380
23MP0002095_abnormal_skin_pigmentation1.76558922
24MP0004782_abnormal_surfactant_physiolog1.73697330
25MP0002938_white_spotting1.67786470
26MP0002277_abnormal_respiratory_mucosa1.65785453
27MP0001800_abnormal_humoral_immune1.65319232
28MP0003693_abnormal_embryo_hatching1.63028855
29MP0008058_abnormal_DNA_repair1.57277229
30MP0005171_absent_coat_pigmentation1.57092696
31MP0005174_abnormal_tail_pigmentation1.56089553
32MP0010155_abnormal_intestine_physiology1.56055467
33MP0005075_abnormal_melanosome_morpholog1.53716561
34MP0003724_increased_susceptibility_to1.49779018
35MP0002163_abnormal_gland_morphology1.42896193
36MP0002254_reproductive_system_inflammat1.39323935
37MP0001919_abnormal_reproductive_system1.37978164
38MP0002166_altered_tumor_susceptibility1.37595377
39MP0003866_abnormal_defecation1.37306726
40MP0003136_yellow_coat_color1.36854944
41MP0010094_abnormal_chromosome_stability1.34333516
42MP0010307_abnormal_tumor_latency1.31485990
43MP0002405_respiratory_system_inflammati1.29908295
44MP0009764_decreased_sensitivity_to1.29105070
45MP0002090_abnormal_vision1.28878715
46MP0006072_abnormal_retinal_apoptosis1.27213924
47MP0002234_abnormal_pharynx_morphology1.25727903
48MP0002837_dystrophic_cardiac_calcinosis1.20344362
49MP0005165_increased_susceptibility_to1.17275333
50MP0009046_muscle_twitch1.16800045
51MP0005389_reproductive_system_phenotype1.16057815
52MP0000678_abnormal_parathyroid_gland1.15899672
53MP0005551_abnormal_eye_electrophysiolog1.15004550
54MP0004381_abnormal_hair_follicle1.12537710
55MP0005332_abnormal_amino_acid1.12410399
56MP0002006_tumorigenesis1.11659555
57MP0001819_abnormal_immune_cell1.10737516
58MP0002452_abnormal_antigen_presenting1.10076034
59MP0002420_abnormal_adaptive_immunity1.09963222
60MP0001501_abnormal_sleep_pattern1.09899678
61MP0002638_abnormal_pupillary_reflex1.09089822
62MP0002723_abnormal_immune_serum1.07005875
63MP0002160_abnormal_reproductive_system0.97361883
64MP0008872_abnormal_physiological_respon0.95446513
65MP0003111_abnormal_nucleus_morphology0.95314933
66MP0003763_abnormal_thymus_physiology0.94188419
67MP0003950_abnormal_plasma_membrane0.93856605
68MP0005025_abnormal_response_to0.93557403
69MP0001845_abnormal_inflammatory_respons0.93431206
70MP0005360_urolithiasis0.92837444
71MP0001663_abnormal_digestive_system0.90860974
72MP0003077_abnormal_cell_cycle0.90218335
73MP0005253_abnormal_eye_physiology0.89812106
74MP0001188_hyperpigmentation0.89694529
75MP0005636_abnormal_mineral_homeostasis0.88903984
76MP0001879_abnormal_lymphatic_vessel0.88777012
77MP0005379_endocrine/exocrine_gland_phen0.88462728
78MP0003786_premature_aging0.86778048
79MP0002102_abnormal_ear_morphology0.84921623
80MP0005646_abnormal_pituitary_gland0.84768613
81MP0005166_decreased_susceptibility_to0.84460886
82MP0008007_abnormal_cellular_replicative0.84343804
83MP0004145_abnormal_muscle_electrophysio0.84002753
84MP0002736_abnormal_nociception_after0.83104545
85MP0001905_abnormal_dopamine_level0.82579937
86MP0005310_abnormal_salivary_gland0.80370338
87MP0001881_abnormal_mammary_gland0.78670195
88MP0005670_abnormal_white_adipose0.78016548
89MP0009643_abnormal_urine_homeostasis0.76491261
90MP0001502_abnormal_circadian_rhythm0.75579521
91MP0006035_abnormal_mitochondrial_morpho0.75169817
92MP0005084_abnormal_gallbladder_morpholo0.74339671
93MP0005085_abnormal_gallbladder_physiolo0.74129391
94MP0004215_abnormal_myocardial_fiber0.73965365
95MP0000049_abnormal_middle_ear0.73662674
96MP0009697_abnormal_copulation0.73119849
97MP0002419_abnormal_innate_immunity0.70845302
98MP0004957_abnormal_blastocyst_morpholog0.70735584
99MP0002693_abnormal_pancreas_physiology0.69396457
100MP0003646_muscle_fatigue0.68205161

Predicted human phenotypes

RankGene SetZ-score
1Mitochondrial inheritance (HP:0001427)4.90356713
2Acute necrotizing encephalopathy (HP:0006965)4.81513028
3Increased hepatocellular lipid droplets (HP:0006565)4.71525083
4Renal Fanconi syndrome (HP:0001994)4.65575640
5Increased CSF lactate (HP:0002490)4.46998147
6Testicular atrophy (HP:0000029)4.36409584
7Abnormal mitochondria in muscle tissue (HP:0008316)4.29231160
8Hepatocellular necrosis (HP:0001404)4.27625207
9Progressive macrocephaly (HP:0004481)4.21705123
10Acute encephalopathy (HP:0006846)4.10843277
11Lipid accumulation in hepatocytes (HP:0006561)4.00301957
12Congenital stationary night blindness (HP:0007642)3.86961740
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.83820804
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.83820804
15Hepatic necrosis (HP:0002605)3.79672895
16Increased neuronal autofluorescent lipopigment (HP:0002074)3.70669985
17Exertional dyspnea (HP:0002875)3.61630141
18Increased intramyocellular lipid droplets (HP:0012240)3.53753473
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.48927811
20Autoimmune thrombocytopenia (HP:0001973)3.43158043
21Visual hallucinations (HP:0002367)3.25181524
22Generalized aminoaciduria (HP:0002909)3.23531678
23Increased serum lactate (HP:0002151)3.17808236
24Congenital ichthyosiform erythroderma (HP:0007431)3.11970109
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.10017224
26Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.06551230
27Autoimmune hemolytic anemia (HP:0001890)3.03058396
28Cerebral edema (HP:0002181)2.94035511
29Increased cerebral lipofuscin (HP:0011813)2.92494377
303-Methylglutaconic aciduria (HP:0003535)2.89562704
31Aplastic anemia (HP:0001915)2.86801344
32Lactic acidosis (HP:0003128)2.86441545
33Opisthotonus (HP:0002179)2.80788937
34Abnormality of renal resorption (HP:0011038)2.79789745
35Increased muscle lipid content (HP:0009058)2.76818373
36Dyschromatopsia (HP:0007641)2.71162903
37Abnormality of urine glucose concentration (HP:0011016)2.70542412
38Glycosuria (HP:0003076)2.70542412
39Respiratory failure (HP:0002878)2.54683996
40Hyperphosphaturia (HP:0003109)2.53622957
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.52679811
42Abnormality of T cell physiology (HP:0011840)2.49831576
43Cutaneous melanoma (HP:0012056)2.49323018
44Spastic diplegia (HP:0001264)2.48846476
45Microretrognathia (HP:0000308)2.46435440
46Exercise intolerance (HP:0003546)2.44879586
47Optic disc pallor (HP:0000543)2.43204383
48Leukodystrophy (HP:0002415)2.42527056
49Degeneration of anterior horn cells (HP:0002398)2.40370901
50Abnormality of the anterior horn cell (HP:0006802)2.40370901
51Absent rod-and cone-mediated responses on ERG (HP:0007688)2.38745731
52Aplasia/Hypoplasia of the fovea (HP:0008060)2.34890936
53Hypoplasia of the fovea (HP:0007750)2.34890936
54Type I transferrin isoform profile (HP:0003642)2.33997805
55Parakeratosis (HP:0001036)2.31891852
56Cheilitis (HP:0100825)2.30088060
57Abnormality of alanine metabolism (HP:0010916)2.25443974
58Hyperalaninemia (HP:0003348)2.25443974
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25443974
60Stomatitis (HP:0010280)2.23076277
61Hypoproteinemia (HP:0003075)2.20267952
62IgG deficiency (HP:0004315)2.20080631
63Renal cortical cysts (HP:0000803)2.18064063
64Chronic mucocutaneous candidiasis (HP:0002728)2.17943370
65Recurrent cutaneous fungal infections (HP:0011370)2.17943370
66Respiratory difficulties (HP:0002880)2.13961302
67Amniotic constriction ring (HP:0009775)2.12400622
68Abnormality of placental membranes (HP:0011409)2.12400622
69Gout (HP:0001997)2.09332814
70Abnormal rod and cone electroretinograms (HP:0008323)2.06379561
71Lethargy (HP:0001254)2.06140407
72Decreased electroretinogram (ERG) amplitude (HP:0000654)2.05698953
73Abnormality of purine metabolism (HP:0004352)2.03576258
74Macrocytic anemia (HP:0001972)2.01064781
75Abnormality of T cells (HP:0002843)1.99426012
76Stenosis of the external auditory canal (HP:0000402)1.98967993
77Cleft eyelid (HP:0000625)1.95689141
78Abnormality of the prostate (HP:0008775)1.95270709
79Clubbing of toes (HP:0100760)1.94478411
80Chromosomal breakage induced by crosslinking agents (HP:0003221)1.91305780
81Metaphyseal dysplasia (HP:0100255)1.91001037
82IgA deficiency (HP:0002720)1.90698587
83Abnormal albumin level (HP:0012116)1.90099889
84Hypoalbuminemia (HP:0003073)1.90099889
85Redundant skin (HP:0001582)1.89955188
86Tetany (HP:0001281)1.89230734
87CNS demyelination (HP:0007305)1.88706247
88Conjunctival hamartoma (HP:0100780)1.88326379
89Abnormality of the fovea (HP:0000493)1.87312258
90Squamous cell carcinoma (HP:0002860)1.86297250
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.83231560
92Abnormal urine phosphate concentration (HP:0012599)1.82415562
93Abnormality of the preputium (HP:0100587)1.79929475
94Mesangial abnormality (HP:0001966)1.79909087
95Spastic paraparesis (HP:0002313)1.79426230
96Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75627365
97Abnormal protein N-linked glycosylation (HP:0012347)1.75627365
98Abnormal protein glycosylation (HP:0012346)1.75627365
99Abnormal glycosylation (HP:0012345)1.75627365
100Abnormality of the ileum (HP:0001549)1.74731607

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.44568271
2CDK193.77796537
3MAP3K123.70060675
4TXK3.51697674
5NUAK13.48108662
6BMPR23.06302985
7BCKDK2.99804407
8BUB12.88723744
9PDK22.71144562
10MST42.63845721
11EIF2AK12.59248585
12NEK12.58075776
13TAOK32.37480142
14MYLK2.02222555
15BMPR1B1.80925765
16OXSR11.68796760
17TSSK61.67931995
18GRK11.67655839
19ADRBK21.65342069
20EIF2AK31.62538812
21ILK1.61328421
22FLT31.59508729
23TLK11.52916095
24NME11.51525320
25MAP4K11.48499561
26VRK21.45994428
27CAMKK21.33041175
28WNK11.25917574
29IKBKB1.23073158
30LRRK21.22300441
31WNK41.12544824
32ZAK1.09537200
33PAK41.07693029
34MAP2K60.99532590
35PAK30.95401370
36DAPK10.93133192
37STK160.91442857
38WEE10.90520150
39FRK0.84900876
40STK390.84297457
41CDK80.82792957
42DYRK20.80190828
43FGFR10.77482947
44MAPKAPK50.77339351
45PAK10.77147132
46KIT0.76224441
47MAP4K20.72972777
48VRK10.72154320
49TIE10.70535179
50CAMK2D0.68489152
51MARK30.67670041
52ABL20.62871461
53INSRR0.60115854
54MKNK10.59038969
55BRSK10.58658007
56TGFBR10.58579291
57PLK30.57947965
58CSNK2A10.56553300
59PRKCI0.55471934
60CSNK2A20.54062865
61CAMK2A0.53642378
62LATS10.53414824
63KDR0.51961292
64PLK40.51655098
65ADRBK10.51566474
66WNK30.51455036
67JAK30.50614080
68CAMK2G0.50343657
69TRIM280.50123339
70AKT30.48486416
71DAPK30.46130721
72STK100.43034497
73FES0.43025546
74PIM20.41706543
75OBSCN0.40712402
76RPS6KB10.39935162
77CSF1R0.39835794
78CSNK1A10.39801013
79ROCK20.38300719
80ATR0.37142055
81PLK10.36949869
82GSK3A0.36218551
83PNCK0.35408688
84AURKB0.34635622
85PBK0.33646162
86PRKACA0.33188440
87PRKCA0.32199955
88LCK0.30729493
89PHKG10.30558364
90PHKG20.30558364
91STK30.29900151
92LIMK10.29711497
93ABL10.29078244
94BRSK20.28399566
95PRKCQ0.27127479
96TYK20.25359269
97MINK10.25317480
98GRK70.24858042
99RPS6KA50.24695300
100PRKG10.24675748

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.42677901
2Ribosome_Homo sapiens_hsa030103.71566415
3Asthma_Homo sapiens_hsa053103.63881943
4Allograft rejection_Homo sapiens_hsa053303.55077996
5Oxidative phosphorylation_Homo sapiens_hsa001903.52508525
6Graft-versus-host disease_Homo sapiens_hsa053322.98854280
7Type I diabetes mellitus_Homo sapiens_hsa049402.96946304
8Parkinsons disease_Homo sapiens_hsa050122.96691160
9Autoimmune thyroid disease_Homo sapiens_hsa053202.88436424
10One carbon pool by folate_Homo sapiens_hsa006702.76121811
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.72815053
12RNA polymerase_Homo sapiens_hsa030202.50457823
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.40826818
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.95902365
15Alzheimers disease_Homo sapiens_hsa050101.93522654
16Rheumatoid arthritis_Homo sapiens_hsa053231.87589519
17Huntingtons disease_Homo sapiens_hsa050161.85715586
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.80317789
19Antigen processing and presentation_Homo sapiens_hsa046121.76753748
20Protein export_Homo sapiens_hsa030601.59663209
21Nitrogen metabolism_Homo sapiens_hsa009101.56083603
22Homologous recombination_Homo sapiens_hsa034401.54399499
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53785750
24Pyrimidine metabolism_Homo sapiens_hsa002401.50028048
25Viral myocarditis_Homo sapiens_hsa054161.40011373
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23716610
27Spliceosome_Homo sapiens_hsa030401.19713453
28Mismatch repair_Homo sapiens_hsa034301.19466200
29Leishmaniasis_Homo sapiens_hsa051401.14396697
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13204855
31Cardiac muscle contraction_Homo sapiens_hsa042601.10922845
32Phototransduction_Homo sapiens_hsa047441.09990798
33Fanconi anemia pathway_Homo sapiens_hsa034601.07277668
34DNA replication_Homo sapiens_hsa030301.06617278
35Staphylococcus aureus infection_Homo sapiens_hsa051501.06287103
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01960487
37Nucleotide excision repair_Homo sapiens_hsa034201.00493307
38Vitamin B6 metabolism_Homo sapiens_hsa007500.97293459
39Purine metabolism_Homo sapiens_hsa002300.96158864
40Sulfur metabolism_Homo sapiens_hsa009200.95633399
41RNA degradation_Homo sapiens_hsa030180.94247514
42Basal transcription factors_Homo sapiens_hsa030220.92112002
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87985408
44Systemic lupus erythematosus_Homo sapiens_hsa053220.87519249
45Hematopoietic cell lineage_Homo sapiens_hsa046400.86547758
46Collecting duct acid secretion_Homo sapiens_hsa049660.85543994
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80950161
48Regulation of autophagy_Homo sapiens_hsa041400.76864778
49RNA transport_Homo sapiens_hsa030130.75344477
50Linoleic acid metabolism_Homo sapiens_hsa005910.74231827
51Propanoate metabolism_Homo sapiens_hsa006400.72104731
52Primary immunodeficiency_Homo sapiens_hsa053400.70146444
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68735128
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68661196
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.63484690
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.62489681
57Metabolic pathways_Homo sapiens_hsa011000.61135318
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58126966
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56766714
60Toxoplasmosis_Homo sapiens_hsa051450.56563108
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.55365247
62Epstein-Barr virus infection_Homo sapiens_hsa051690.53532052
63Glutathione metabolism_Homo sapiens_hsa004800.52673314
64Ether lipid metabolism_Homo sapiens_hsa005650.51649187
65African trypanosomiasis_Homo sapiens_hsa051430.51144006
66Folate biosynthesis_Homo sapiens_hsa007900.49740444
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49223298
68Selenocompound metabolism_Homo sapiens_hsa004500.48876133
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48749954
70Herpes simplex infection_Homo sapiens_hsa051680.48438985
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47597825
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47540222
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46056679
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42164496
75Steroid biosynthesis_Homo sapiens_hsa001000.41948889
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41408132
77Non-homologous end-joining_Homo sapiens_hsa034500.41230720
78Tryptophan metabolism_Homo sapiens_hsa003800.39896950
79Base excision repair_Homo sapiens_hsa034100.34826920
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31600336
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.30370756
82Butanoate metabolism_Homo sapiens_hsa006500.28832956
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28072936
84Chemical carcinogenesis_Homo sapiens_hsa052040.26735209
85T cell receptor signaling pathway_Homo sapiens_hsa046600.26354951
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26295059
87Influenza A_Homo sapiens_hsa051640.25924058
88Tuberculosis_Homo sapiens_hsa051520.23480013
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23328442
90Malaria_Homo sapiens_hsa051440.22529882
91Sulfur relay system_Homo sapiens_hsa041220.21921092
92N-Glycan biosynthesis_Homo sapiens_hsa005100.21702829
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.20784340
94Measles_Homo sapiens_hsa051620.19235656
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18943243
96Fat digestion and absorption_Homo sapiens_hsa049750.18817900
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18140254
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.16963424
99Pyruvate metabolism_Homo sapiens_hsa006200.15786201
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15510078

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