TXNP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)9.92569657
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450919.25913029
3pyrimidine ribonucleoside catabolic process (GO:0046133)8.75840391
4eosinophil chemotaxis (GO:0048245)4.54493868
5negative regulation by host of viral transcription (GO:0043922)4.50775598
6pyrimidine nucleoside catabolic process (GO:0046135)4.32652288
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.24452005
8eosinophil migration (GO:0072677)4.10248514
9regulation of chronic inflammatory response (GO:0002676)4.05114903
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.04608222
11piRNA metabolic process (GO:0034587)3.98740087
12positive regulation of T cell apoptotic process (GO:0070234)3.92555656
13negative regulation of viral genome replication (GO:0045071)3.84923810
14positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.74158974
15deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.72250478
16protein neddylation (GO:0045116)3.68210976
17regulation of regulatory T cell differentiation (GO:0045589)3.64007260
18positive regulation of natural killer cell mediated immunity (GO:0002717)3.63052702
19positive T cell selection (GO:0043368)3.60245044
20positive regulation of defense response to virus by host (GO:0002230)3.57457098
21respiratory electron transport chain (GO:0022904)3.49891640
22negative regulation of T cell apoptotic process (GO:0070233)3.49630500
23positive thymic T cell selection (GO:0045059)3.47195886
24macrophage chemotaxis (GO:0048246)3.46178644
25electron transport chain (GO:0022900)3.43891205
26ATP synthesis coupled proton transport (GO:0015986)3.40515183
27energy coupled proton transport, down electrochemical gradient (GO:0015985)3.40515183
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.40251781
29regulation of activation of Janus kinase activity (GO:0010533)3.39338915
30positive regulation of interleukin-8 secretion (GO:2000484)3.38181016
31proteasome assembly (GO:0043248)3.34438067
32sequestering of actin monomers (GO:0042989)3.31413749
33regulation of cellular amino acid metabolic process (GO:0006521)3.24615654
34DNA demethylation (GO:0080111)3.19288730
35behavioral response to nicotine (GO:0035095)3.17564706
36cytolysis (GO:0019835)3.17455514
37positive regulation of calcium-mediated signaling (GO:0050850)3.12663793
38positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.11799979
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.07792235
40purine-containing compound salvage (GO:0043101)3.07159415
41negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.06835862
42protein complex biogenesis (GO:0070271)3.06457561
43exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.04799355
44chaperone-mediated protein transport (GO:0072321)3.02299091
45regulation of lymphocyte chemotaxis (GO:1901623)3.01314482
46regulation of mononuclear cell migration (GO:0071675)3.00272253
47pyrimidine-containing compound catabolic process (GO:0072529)2.97934135
48positive regulation of translational initiation (GO:0045948)2.97582001
49regulation of natural killer cell mediated immunity (GO:0002715)2.94503865
50regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.94503865
51positive regulation of cell killing (GO:0031343)2.94122161
52negative regulation of T cell differentiation in thymus (GO:0033085)2.93509841
53positive regulation of lymphocyte apoptotic process (GO:0070230)2.90652662
54positive regulation of interleukin-1 beta secretion (GO:0050718)2.90573434
55DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.88156811
56respiratory chain complex IV assembly (GO:0008535)2.86883365
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85097579
58positive regulation of humoral immune response (GO:0002922)2.84937339
59purine nucleotide salvage (GO:0032261)2.84889835
60mitochondrial respiratory chain complex I assembly (GO:0032981)2.83666058
61NADH dehydrogenase complex assembly (GO:0010257)2.83666058
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.83666058
63cytochrome complex assembly (GO:0017004)2.83184656
64DNA dealkylation (GO:0035510)2.80952891
65regulation of T cell tolerance induction (GO:0002664)2.78223761
66positive regulation of tolerance induction (GO:0002645)2.77829549
67signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.77624068
68intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.77624068
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.77123828
70negative regulation of ligase activity (GO:0051352)2.77123828
71signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.76127294
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.76127294
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.76127294
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.74610358
75positive regulation of interleukin-1 secretion (GO:0050716)2.73843124
76positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.73533708
77regulation of interleukin-8 secretion (GO:2000482)2.69609804
78regulation of leukocyte mediated cytotoxicity (GO:0001910)2.69498101
79regulation of viral genome replication (GO:0045069)2.68457998
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.67171531
81tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.64661052
82RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.64661052
83mitochondrial respiratory chain complex assembly (GO:0033108)2.63255843
84signal transduction involved in DNA damage checkpoint (GO:0072422)2.62400206
85signal transduction involved in DNA integrity checkpoint (GO:0072401)2.62400206
86signal transduction involved in cell cycle checkpoint (GO:0072395)2.59562820
87regulation of interleukin-1 beta secretion (GO:0050706)2.59459336
88positive regulation of uterine smooth muscle contraction (GO:0070474)2.59366945
89regulation of cell killing (GO:0031341)2.58391571
90metallo-sulfur cluster assembly (GO:0031163)2.57225293
91iron-sulfur cluster assembly (GO:0016226)2.57225293
92deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.56323016
93male meiosis I (GO:0007141)2.55001748
94antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.54288504
95hydrogen ion transmembrane transport (GO:1902600)2.53870862
96transcription elongation from RNA polymerase III promoter (GO:0006385)2.53548148
97termination of RNA polymerase III transcription (GO:0006386)2.53548148
98cytidine metabolic process (GO:0046087)10.1242513
99cytidine catabolic process (GO:0006216)10.1242513
100cytidine deamination (GO:0009972)10.1242513

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human9.02113519
2EZH2_22144423_ChIP-Seq_EOC_Human7.43159586
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.43149764
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.27120741
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.11435140
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.09431972
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.02856610
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.00581015
9VDR_22108803_ChIP-Seq_LS180_Human2.98877771
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.63384731
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.44513914
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24117634
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.23726383
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.15713876
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14133911
16VDR_23849224_ChIP-Seq_CD4+_Human2.03936077
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.83032671
18ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81953047
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79154279
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.67406410
21FOXP3_21729870_ChIP-Seq_TREG_Human1.64476143
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.62569244
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.53620048
24POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.53329646
25E2F7_22180533_ChIP-Seq_HELA_Human1.51142777
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50660148
27ZNF274_21170338_ChIP-Seq_K562_Hela1.50412734
28HTT_18923047_ChIP-ChIP_STHdh_Human1.42544888
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37472756
30IRF1_19129219_ChIP-ChIP_H3396_Human1.35810795
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34401632
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.33916958
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32515817
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31872800
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31276369
36TP53_22573176_ChIP-Seq_HFKS_Human1.28268034
37EWS_26573619_Chip-Seq_HEK293_Human1.27540208
38MYB_26560356_Chip-Seq_TH2_Human1.27047470
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26108408
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24209241
41MYC_18940864_ChIP-ChIP_HL60_Human1.21485866
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20519834
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20032832
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.19315888
45TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.17017520
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15153607
47NANOG_20526341_ChIP-Seq_ESCs_Human1.14896187
48TAF2_19829295_ChIP-Seq_ESCs_Human1.14101816
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14034327
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.13416449
51AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10630766
52GATA3_26560356_Chip-Seq_TH2_Human1.10579110
53FOXH1_21741376_ChIP-Seq_EPCs_Human1.09895557
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09631778
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06580882
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.02812303
57ER_23166858_ChIP-Seq_MCF-7_Human1.02226371
58ELK1_19687146_ChIP-ChIP_HELA_Human1.01613944
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00624300
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00614655
61GATA3_27048872_Chip-Seq_THYMUS_Human1.00173720
62E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99750916
63IGF1R_20145208_ChIP-Seq_DFB_Human0.99364232
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98481571
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98298007
66CBP_20019798_ChIP-Seq_JUKART_Human0.98298007
67SOX2_19829295_ChIP-Seq_ESCs_Human0.97270278
68NANOG_19829295_ChIP-Seq_ESCs_Human0.97270278
69AR_20517297_ChIP-Seq_VCAP_Human0.97022708
70FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96601695
71FOXA1_25329375_ChIP-Seq_VCAP_Human0.96601695
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93505414
73NCOR_22424771_ChIP-Seq_293T_Human0.93061043
74PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90685189
75GATA3_21878914_ChIP-Seq_MCF-7_Human0.90651155
76RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90123474
77ERG_20517297_ChIP-Seq_VCAP_Human0.89870254
78SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88507586
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87588713
80P300_19829295_ChIP-Seq_ESCs_Human0.84953930
81PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84853824
82MYC_18358816_ChIP-ChIP_MESCs_Mouse0.84487443
83DCP1A_22483619_ChIP-Seq_HELA_Human0.84017646
84CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.83240636
85RUNX_20019798_ChIP-Seq_JUKART_Human0.82373207
86PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81982856
87FOXH1_21741376_ChIP-Seq_ESCs_Human0.81711744
88HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80745337
89ELK1_22589737_ChIP-Seq_MCF10A_Human0.80467058
90MYC_18555785_ChIP-Seq_MESCs_Mouse0.79737423
91GABP_19822575_ChIP-Seq_HepG2_Human0.78907226
92EZH2_27294783_Chip-Seq_NPCs_Mouse0.78822017
93PRDM14_20953172_ChIP-Seq_ESCs_Human0.78140242
94CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.77890420
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.77265324
96GATA3_26560356_Chip-Seq_TH1_Human0.77068852
97YY1_21170310_ChIP-Seq_MESCs_Mouse0.77042685
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.76973029
99OCT4_20526341_ChIP-Seq_ESCs_Human0.74737723
100TCF4_22108803_ChIP-Seq_LS180_Human0.73391508

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.05443890
2MP0001188_hyperpigmentation3.20448520
3MP0008877_abnormal_DNA_methylation3.00457442
4MP0009785_altered_susceptibility_to2.91609668
5MP0006082_CNS_inflammation2.61989270
6MP0003718_maternal_effect2.53040648
7MP0008789_abnormal_olfactory_epithelium2.41330737
8MP0005646_abnormal_pituitary_gland2.37015714
9MP0001835_abnormal_antigen_presentation2.35214185
10MP0001873_stomach_inflammation2.21128315
11MP0002163_abnormal_gland_morphology2.09421527
12MP0002822_catalepsy2.09037021
13MP0006292_abnormal_olfactory_placode2.04816419
14MP0003866_abnormal_defecation2.02729848
15MP0005000_abnormal_immune_tolerance1.98856862
16MP0002876_abnormal_thyroid_physiology1.95417717
17MP0002234_abnormal_pharynx_morphology1.87553124
18MP0009333_abnormal_splenocyte_physiolog1.87467371
19MP0002132_abnormal_respiratory_system1.80779850
20MP0005645_abnormal_hypothalamus_physiol1.76284742
21MP0002148_abnormal_hypersensitivity_rea1.74616836
22MP0003195_calcinosis1.70696633
23MP0005394_taste/olfaction_phenotype1.69316653
24MP0005499_abnormal_olfactory_system1.69316653
25MP0003763_abnormal_thymus_physiology1.68439986
26MP0000685_abnormal_immune_system1.66601784
27MP0001529_abnormal_vocalization1.64381431
28MP0003693_abnormal_embryo_hatching1.60831573
29MP0005360_urolithiasis1.57486389
30MP0001905_abnormal_dopamine_level1.55862150
31MP0002138_abnormal_hepatobiliary_system1.54874353
32MP0001800_abnormal_humoral_immune1.51470239
33MP0002723_abnormal_immune_serum1.50072473
34MP0001661_extended_life_span1.49358658
35MP0005387_immune_system_phenotype1.44529308
36MP0001790_abnormal_immune_system1.44529308
37MP0002420_abnormal_adaptive_immunity1.42867081
38MP0006072_abnormal_retinal_apoptosis1.42236338
39MP0005379_endocrine/exocrine_gland_phen1.40514430
40MP0001819_abnormal_immune_cell1.37188960
41MP0001919_abnormal_reproductive_system1.35866908
42MP0005025_abnormal_response_to1.35154299
43MP0002277_abnormal_respiratory_mucosa1.34609587
44MP0003950_abnormal_plasma_membrane1.33873360
45MP0005389_reproductive_system_phenotype1.29415706
46MP0003786_premature_aging1.28727890
47MP0005551_abnormal_eye_electrophysiolog1.27952213
48MP0002638_abnormal_pupillary_reflex1.25912107
49MP0002405_respiratory_system_inflammati1.20302951
50MP0002210_abnormal_sex_determination1.16789880
51MP0002837_dystrophic_cardiac_calcinosis1.15732847
52MP0000716_abnormal_immune_system1.15198435
53MP0005377_hearing/vestibular/ear_phenot1.14957836
54MP0003878_abnormal_ear_physiology1.14957836
55MP0003436_decreased_susceptibility_to1.14246751
56MP0001119_abnormal_female_reproductive1.14040060
57MP0005647_abnormal_sex_gland1.11680515
58MP0001984_abnormal_olfaction1.11364818
59MP0000372_irregular_coat_pigmentation1.10516474
60MP0002160_abnormal_reproductive_system1.09149089
61MP0002102_abnormal_ear_morphology1.08491872
62MP0008872_abnormal_physiological_respon1.08127825
63MP0010155_abnormal_intestine_physiology1.07831293
64MP0000703_abnormal_thymus_morphology1.05927942
65MP0002452_abnormal_antigen_presenting1.05615548
66MP0002398_abnormal_bone_marrow1.05083319
67MP0000631_abnormal_neuroendocrine_gland1.04087555
68MP0001502_abnormal_circadian_rhythm1.02251719
69MP0004142_abnormal_muscle_tone1.01501103
70MP0001485_abnormal_pinna_reflex1.00900459
71MP0001845_abnormal_inflammatory_respons0.99559026
72MP0005410_abnormal_fertilization0.99028323
73MP0002722_abnormal_immune_system0.98999583
74MP0006036_abnormal_mitochondrial_physio0.98813380
75MP0006276_abnormal_autonomic_nervous0.94944952
76MP0002272_abnormal_nervous_system0.94250663
77MP0001929_abnormal_gametogenesis0.93555564
78MP0004782_abnormal_surfactant_physiolog0.93364406
79MP0008058_abnormal_DNA_repair0.91389838
80MP0003448_altered_tumor_morphology0.87663583
81MP0000653_abnormal_sex_gland0.87030107
82MP0009745_abnormal_behavioral_response0.86838553
83MP0002006_tumorigenesis0.85671877
84MP0004145_abnormal_muscle_electrophysio0.85339745
85MP0003137_abnormal_impulse_conducting0.83158530
86MP0002933_joint_inflammation0.82901319
87MP0000689_abnormal_spleen_morphology0.82859925
88MP0005395_other_phenotype0.81998419
89MP0001986_abnormal_taste_sensitivity0.81625620
90MP0002166_altered_tumor_susceptibility0.81076169
91MP0002429_abnormal_blood_cell0.80889037
92MP0004043_abnormal_pH_regulation0.79856428
93MP0001853_heart_inflammation0.79274750
94MP0001348_abnormal_lacrimal_gland0.77135220
95MP0003119_abnormal_digestive_system0.75251521
96MP0002693_abnormal_pancreas_physiology0.74710023
97MP0005310_abnormal_salivary_gland0.74310830
98MP0009697_abnormal_copulation0.72890500
99MP0002909_abnormal_adrenal_gland0.71910022
100MP0003806_abnormal_nucleotide_metabolis0.71786718

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.78111582
2Mitochondrial inheritance (HP:0001427)4.53052880
3Autoimmune hemolytic anemia (HP:0001890)4.24716039
4Abnormal mitochondria in muscle tissue (HP:0008316)4.17326304
5Progressive macrocephaly (HP:0004481)3.91680210
6Hepatocellular necrosis (HP:0001404)3.85187726
7Acute encephalopathy (HP:0006846)3.81537223
8Hypoproteinemia (HP:0003075)3.79892511
9Increased CSF lactate (HP:0002490)3.71537186
10Hepatic necrosis (HP:0002605)3.52073053
11Autoimmune thrombocytopenia (HP:0001973)3.51751788
12IgG deficiency (HP:0004315)3.42263315
13Abnormality of T cell number (HP:0011839)3.37265872
14T lymphocytopenia (HP:0005403)3.28571455
15Increased IgM level (HP:0003496)3.20626356
16Absent rod-and cone-mediated responses on ERG (HP:0007688)3.19406765
17Cerebral edema (HP:0002181)3.14024438
18Molar tooth sign on MRI (HP:0002419)3.02306152
19Abnormality of midbrain morphology (HP:0002418)3.02306152
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.01192115
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.01192115
22Congenital stationary night blindness (HP:0007642)2.94167720
23Increased hepatocellular lipid droplets (HP:0006565)2.88953201
24Severe combined immunodeficiency (HP:0004430)2.86759374
25Abnormality of the prostate (HP:0008775)2.84374110
26Abnormality of T cells (HP:0002843)2.72386119
27Abnormal albumin level (HP:0012116)2.69523078
28Hypoalbuminemia (HP:0003073)2.69523078
29Abnormality of B cell number (HP:0010975)2.68805657
30Renal Fanconi syndrome (HP:0001994)2.63828605
31Generalized aminoaciduria (HP:0002909)2.61528808
32Aplastic anemia (HP:0001915)2.61301954
33Pancreatic cysts (HP:0001737)2.55544803
343-Methylglutaconic aciduria (HP:0003535)2.53135851
35B lymphocytopenia (HP:0010976)2.52869546
36Abnormal rod and cone electroretinograms (HP:0008323)2.46154293
37Increased intramyocellular lipid droplets (HP:0012240)2.44076062
38Thyroiditis (HP:0100646)2.43805713
39Obstructive lung disease (HP:0006536)2.41166214
40Chronic obstructive pulmonary disease (HP:0006510)2.41166214
41Optic disc pallor (HP:0000543)2.40788996
42Parakeratosis (HP:0001036)2.38517298
43Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.38452022
44Lipid accumulation in hepatocytes (HP:0006561)2.33756315
45Increased serum lactate (HP:0002151)2.32003772
46Combined immunodeficiency (HP:0005387)2.29845520
47Elevated erythrocyte sedimentation rate (HP:0003565)2.28826414
48Septo-optic dysplasia (HP:0100842)2.27696630
49Abnormality of eosinophils (HP:0001879)2.27145554
50Testicular atrophy (HP:0000029)2.26785420
51Renal cortical cysts (HP:0000803)2.24966216
52Lactic acidosis (HP:0003128)2.22449768
53Respiratory failure (HP:0002878)2.22272532
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.19424099
55Abnormality of the phalanges of the 5th finger (HP:0004213)2.18431427
56Supernumerary spleens (HP:0009799)2.14920559
57Abnormality of the labia minora (HP:0012880)2.10686662
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.09641110
59Short middle phalanx of the 5th finger (HP:0004220)2.09053701
60Abnormal respiratory motile cilium physiology (HP:0012261)2.06846695
61Short tibia (HP:0005736)2.02558532
62Exercise intolerance (HP:0003546)2.01149285
63Prostate neoplasm (HP:0100787)1.96765890
64Lymphopenia (HP:0001888)1.93880368
65Myokymia (HP:0002411)1.92823724
66Chronic bronchitis (HP:0004469)1.92037721
67Leukodystrophy (HP:0002415)1.91352219
68Stomatitis (HP:0010280)1.91132418
69Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.90939200
70Pancreatic fibrosis (HP:0100732)1.90606715
71Abnormality of DNA repair (HP:0003254)1.90383504
72Abnormality of T cell physiology (HP:0011840)1.89437314
73Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86616883
74Methylmalonic acidemia (HP:0002912)1.86406613
75True hermaphroditism (HP:0010459)1.85531215
76Abnormal delayed hypersensitivity skin test (HP:0002963)1.85245235
77Increased muscle lipid content (HP:0009058)1.84936460
78Abnormality of cells of the lymphoid lineage (HP:0012140)1.83922923
79Facial hemangioma (HP:0000329)1.81850626
80Aplasia/Hypoplasia of the tibia (HP:0005772)1.81749544
81Pancytopenia (HP:0001876)1.79561295
82Hypoplasia of the fovea (HP:0007750)1.79500067
83Aplasia/Hypoplasia of the fovea (HP:0008060)1.79500067
84Entropion (HP:0000621)1.78802047
85Macrocytic anemia (HP:0001972)1.78454057
86Exertional dyspnea (HP:0002875)1.77197885
87Lethargy (HP:0001254)1.76626644
88Medial flaring of the eyebrow (HP:0010747)1.75493399
89Type I transferrin isoform profile (HP:0003642)1.74458643
90Oligodactyly (hands) (HP:0001180)1.72776844
91Abdominal situs inversus (HP:0003363)1.71920912
92Abnormality of abdominal situs (HP:0011620)1.71920912
93Abnormality of the alveolar ridges (HP:0006477)1.71615058
94Aplasia/Hypoplasia of the ulna (HP:0006495)1.70573131
95Lymphoma (HP:0002665)1.70541160
96Fibular aplasia (HP:0002990)1.68551128
97Aplasia/hypoplasia of the uterus (HP:0008684)1.68198553
98Eosinophilia (HP:0001880)1.68033949
99Bronchitis (HP:0012387)1.66559015
100Methylmalonic aciduria (HP:0012120)1.62953728

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.35883318
2KDR4.74830122
3TESK23.37396822
4BUB12.74910601
5MST42.72103984
6ZAK2.63515480
7ADRBK22.43492005
8WNK42.24706211
9BCKDK2.19500607
10PDK22.00645379
11TLK11.93539805
12BRAF1.92820677
13LIMK11.92376765
14MAP3K121.82059870
15VRK11.76117910
16NUAK11.63919811
17TRIM281.59405425
18BCR1.54245698
19ARAF1.53177472
20EIF2AK11.48154025
21GRK11.47787297
22ITK1.47398381
23EIF2AK31.44524549
24GRK71.42040329
25VRK21.41528834
26WNK31.35613290
27MAP4K11.29014209
28NME11.22139677
29TAOK31.21497965
30PRKCQ1.18867570
31CAMKK21.16336603
32MAP3K91.10136357
33PLK41.09692979
34TIE11.08980634
35TESK11.07333458
36AKT31.01136532
37NME20.91420184
38CSNK1G30.90145187
39TEC0.89346455
40NEK10.89246895
41SYK0.88827561
42AURKA0.82506058
43MAP3K110.82200745
44GRK60.80437177
45LCK0.79668423
46CDC70.78717780
47NTRK20.78565548
48PIM10.77291217
49DAPK20.75335740
50DYRK20.72165011
51CSNK1A1L0.71946226
52CDK80.69341253
53JAK30.69008741
54FRK0.67326248
55PRKCI0.65880261
56CAMK2A0.63926073
57MYLK0.63519988
58STK390.63107763
59OXSR10.60764927
60WEE10.60311514
61PKN10.59057779
62PAK10.58741300
63MAP2K60.57868938
64BMPR1B0.57759352
65IKBKE0.57325089
66ATR0.55918585
67MAPK130.55574487
68TNK20.55517965
69RAF10.55212947
70IKBKB0.55117508
71CSK0.54964862
72PRKACA0.54485138
73INSRR0.52970093
74CSNK1G10.52817979
75LYN0.50041504
76CSNK1G20.49623535
77PLK10.46824555
78MUSK0.45078850
79MAP2K70.44532293
80DAPK10.43631180
81CSNK2A10.42960536
82OBSCN0.42837828
83PRKCA0.41553467
84CSNK2A20.39780536
85MAP3K50.39757136
86AURKB0.39563658
87CSNK1A10.39068376
88CAMKK10.38897987
89FYN0.38466123
90PASK0.38396657
91MAP3K40.37857725
92RPS6KA50.37667329
93PIM20.37458429
94CHEK20.36956842
95FES0.36834992
96PLK30.36582308
97IGF1R0.33843394
98KIT0.33621444
99BTK0.33377589
100PDK10.33134384

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.67045346
2Oxidative phosphorylation_Homo sapiens_hsa001903.84612190
3Primary immunodeficiency_Homo sapiens_hsa053403.75751030
4Parkinsons disease_Homo sapiens_hsa050123.40943400
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.76859598
6Graft-versus-host disease_Homo sapiens_hsa053322.53653336
7Protein export_Homo sapiens_hsa030602.43457149
8Ribosome_Homo sapiens_hsa030102.41482752
9Autoimmune thyroid disease_Homo sapiens_hsa053202.28499032
10Antigen processing and presentation_Homo sapiens_hsa046122.19472606
11RNA polymerase_Homo sapiens_hsa030202.16696251
12Allograft rejection_Homo sapiens_hsa053302.10814187
13Huntingtons disease_Homo sapiens_hsa050162.09184813
14DNA replication_Homo sapiens_hsa030302.07259369
15Rheumatoid arthritis_Homo sapiens_hsa053232.03512148
16Alzheimers disease_Homo sapiens_hsa050102.02263860
17Nucleotide excision repair_Homo sapiens_hsa034202.01360463
18Mismatch repair_Homo sapiens_hsa034301.95197639
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.93847083
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.86988111
21Type I diabetes mellitus_Homo sapiens_hsa049401.74409282
22Cardiac muscle contraction_Homo sapiens_hsa042601.74066291
23RNA degradation_Homo sapiens_hsa030181.73924801
24Hematopoietic cell lineage_Homo sapiens_hsa046401.72893246
25Basal transcription factors_Homo sapiens_hsa030221.49558782
26T cell receptor signaling pathway_Homo sapiens_hsa046601.48181731
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36577247
28Pyrimidine metabolism_Homo sapiens_hsa002401.23823917
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20389656
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17794603
31Phototransduction_Homo sapiens_hsa047441.17111978
32Salmonella infection_Homo sapiens_hsa051321.16166279
33Asthma_Homo sapiens_hsa053101.15814709
34Fanconi anemia pathway_Homo sapiens_hsa034601.15265203
35Homologous recombination_Homo sapiens_hsa034401.14880782
36Linoleic acid metabolism_Homo sapiens_hsa005911.13039827
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09575093
38One carbon pool by folate_Homo sapiens_hsa006701.06458062
39Purine metabolism_Homo sapiens_hsa002301.02816337
40Caffeine metabolism_Homo sapiens_hsa002321.01896643
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96222659
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90544543
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84818156
44Intestinal immune network for IgA production_Homo sapiens_hsa046720.82656781
45Measles_Homo sapiens_hsa051620.82633553
46Nitrogen metabolism_Homo sapiens_hsa009100.81108233
47Spliceosome_Homo sapiens_hsa030400.80224933
48RNA transport_Homo sapiens_hsa030130.79417581
49Collecting duct acid secretion_Homo sapiens_hsa049660.72125410
50Olfactory transduction_Homo sapiens_hsa047400.71375804
51Nicotine addiction_Homo sapiens_hsa050330.69795921
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69054272
53Propanoate metabolism_Homo sapiens_hsa006400.68617172
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64658408
55Base excision repair_Homo sapiens_hsa034100.64249012
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63571579
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62138481
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.61953607
59Cell cycle_Homo sapiens_hsa041100.59574521
60Folate biosynthesis_Homo sapiens_hsa007900.56853508
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56459788
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53630570
63Malaria_Homo sapiens_hsa051440.53569488
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52451303
65Morphine addiction_Homo sapiens_hsa050320.50726490
66Butanoate metabolism_Homo sapiens_hsa006500.50544002
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49179995
68Ether lipid metabolism_Homo sapiens_hsa005650.48781167
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46098058
70GABAergic synapse_Homo sapiens_hsa047270.45819121
71Chemical carcinogenesis_Homo sapiens_hsa052040.45421832
72Peroxisome_Homo sapiens_hsa041460.43391544
73Metabolic pathways_Homo sapiens_hsa011000.42092917
74Systemic lupus erythematosus_Homo sapiens_hsa053220.41867383
75Serotonergic synapse_Homo sapiens_hsa047260.41688875
76African trypanosomiasis_Homo sapiens_hsa051430.40926393
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.40891716
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39704554
79Mineral absorption_Homo sapiens_hsa049780.39146858
80Oocyte meiosis_Homo sapiens_hsa041140.38804743
81p53 signaling pathway_Homo sapiens_hsa041150.37239719
82Viral myocarditis_Homo sapiens_hsa054160.36957473
83Retinol metabolism_Homo sapiens_hsa008300.36565916
84Herpes simplex infection_Homo sapiens_hsa051680.35593222
85Tryptophan metabolism_Homo sapiens_hsa003800.34006383
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33592851
87Ovarian steroidogenesis_Homo sapiens_hsa049130.32347476
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32235557
89Fat digestion and absorption_Homo sapiens_hsa049750.31717352
90Chemokine signaling pathway_Homo sapiens_hsa040620.31008392
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.29923071
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29803942
93Taste transduction_Homo sapiens_hsa047420.27492656
94Pyruvate metabolism_Homo sapiens_hsa006200.25153162
95Synaptic vesicle cycle_Homo sapiens_hsa047210.25035751
96Steroid biosynthesis_Homo sapiens_hsa001000.24255176
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24184632
98HTLV-I infection_Homo sapiens_hsa051660.22883010
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22623623
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21603454

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