TXNP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1eosinophil chemotaxis (GO:0048245)6.38289598
2negative regulation by host of viral transcription (GO:0043922)6.12911445
3eosinophil migration (GO:0072677)5.76877216
4regulation of T cell tolerance induction (GO:0002664)5.44240079
5regulation of regulatory T cell differentiation (GO:0045589)5.40581005
6positive regulation of tolerance induction (GO:0002645)5.34718794
7regulation of lymphocyte chemotaxis (GO:1901623)5.07290820
8pyrimidine nucleoside catabolic process (GO:0046135)4.99987244
9sequestering of actin monomers (GO:0042989)4.98825222
10positive regulation of calcium-mediated signaling (GO:0050850)4.93951952
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.93766635
12Arp2/3 complex-mediated actin nucleation (GO:0034314)4.93238987
13negative regulation of T cell apoptotic process (GO:0070233)4.91912876
14positive regulation of interleukin-8 secretion (GO:2000484)4.84921170
15positive T cell selection (GO:0043368)4.84363383
16macrophage chemotaxis (GO:0048246)4.82190582
17positive thymic T cell selection (GO:0045059)4.77654267
18negative regulation of viral genome replication (GO:0045071)4.50176227
19regulation of tolerance induction (GO:0002643)4.44962446
20actin nucleation (GO:0045010)4.39785311
21cytolysis (GO:0019835)4.32406222
22T cell migration (GO:0072678)4.32356535
23positive regulation of monocyte chemotaxis (GO:0090026)4.29536963
24regulation of activation of Janus kinase activity (GO:0010533)4.17889300
25regulation of T cell chemotaxis (GO:0010819)4.16710456
26positive regulation of T cell chemotaxis (GO:0010820)4.16710456
27regulation of chronic inflammatory response (GO:0002676)4.12965627
28positive regulation of lymphocyte migration (GO:2000403)3.98514647
29cellular response to interleukin-15 (GO:0071350)3.97623813
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.96760949
31positive regulation of gamma-delta T cell activation (GO:0046645)3.86399851
32positive regulation of T cell apoptotic process (GO:0070234)3.86294092
33positive regulation of natural killer cell mediated immunity (GO:0002717)3.84608532
34positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.83776640
35regulation of interleukin-8 secretion (GO:2000482)3.69996681
36positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.68412396
37thymic T cell selection (GO:0045061)3.62902989
38regulation of mononuclear cell migration (GO:0071675)3.61915836
39negative T cell selection (GO:0043383)3.57890950
40regulation of calcium-mediated signaling (GO:0050848)3.57374080
41protein neddylation (GO:0045116)3.55971645
42positive regulation of B cell differentiation (GO:0045579)3.55024892
43modulation by host of viral transcription (GO:0043921)3.49441259
44modulation by host of symbiont transcription (GO:0052472)3.49441259
45positive regulation of defense response to virus by host (GO:0002230)3.47861387
46regulation of B cell receptor signaling pathway (GO:0050855)3.42356710
47T cell costimulation (GO:0031295)3.38581432
48modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)3.37573599
49negative regulation of viral transcription (GO:0032897)3.37164522
50regulation of T cell apoptotic process (GO:0070232)3.36232670
51lymphocyte costimulation (GO:0031294)3.34401683
52positive regulation of T cell mediated cytotoxicity (GO:0001916)3.33627624
53negative regulation of lymphocyte apoptotic process (GO:0070229)3.32861573
54DNA demethylation (GO:0080111)3.32483206
55positive regulation of lamellipodium assembly (GO:0010592)3.32402571
56regulation of B cell differentiation (GO:0045577)3.32039553
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.29728655
58regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.29446369
59regulation of natural killer cell mediated immunity (GO:0002715)3.29446369
60response to interleukin-15 (GO:0070672)3.28754756
61T cell selection (GO:0045058)3.28528267
62regulation of T cell receptor signaling pathway (GO:0050856)3.28363514
63positive regulation of cell killing (GO:0031343)3.25481682
64lymphocyte chemotaxis (GO:0048247)3.24825754
65regulation of macrophage chemotaxis (GO:0010758)3.23282751
66positive regulation of interleukin-4 production (GO:0032753)3.20914642
67regulation of gamma-delta T cell differentiation (GO:0045586)3.19019838
68T cell receptor signaling pathway (GO:0050852)3.18399174
69monocyte chemotaxis (GO:0002548)3.18320880
70antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.16091346
71regulation of leukocyte mediated cytotoxicity (GO:0001910)3.15896003
72regulation of chemokine-mediated signaling pathway (GO:0070099)3.15485752
73regulation of interleukin-2 biosynthetic process (GO:0045076)3.15309411
74regulation of viral genome replication (GO:0045069)3.14504814
75pyrimidine-containing compound catabolic process (GO:0072529)3.14208774
76negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.12533847
77regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.09478458
78positive regulation of lymphocyte apoptotic process (GO:0070230)3.08806727
79positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.07937975
80regulation of cellular amino acid metabolic process (GO:0006521)3.06003336
81respiratory burst (GO:0045730)3.05908093
82negative regulation of calcium ion transport into cytosol (GO:0010523)3.03132936
83negative regulation of viral process (GO:0048525)3.00052213
84regulation of lymphocyte migration (GO:2000401)2.97203691
85positive regulation of translational initiation (GO:0045948)2.92781530
86natural killer cell activation (GO:0030101)2.88693701
87cellular defense response (GO:0006968)2.86797667
88positive regulation of T cell migration (GO:2000406)2.85895101
89regulation of cell killing (GO:0031341)2.85746223
90negative thymic T cell selection (GO:0045060)2.85057921
91DNA dealkylation (GO:0035510)2.84900872
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.84134387
93regulation of T cell mediated cytotoxicity (GO:0001914)2.83315872
94regulation of interleukin-12 biosynthetic process (GO:0045075)2.80005350
95cytidine metabolic process (GO:0046087)11.9208491
96cytidine catabolic process (GO:0006216)11.9208491
97cytidine deamination (GO:0009972)11.9208491
98regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:004509110.9187644
99pyrimidine ribonucleoside catabolic process (GO:0046133)10.4412505
100DNA deamination (GO:0045006)10.2947781

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.04940304
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.69625944
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.40105897
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.36874536
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.12845434
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.07136458
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.03098967
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.92504733
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.60196626
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.56700445
11MYB_26560356_Chip-Seq_TH2_Human2.52668390
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.48709253
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.31921421
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.21708811
15VDR_22108803_ChIP-Seq_LS180_Human2.14093790
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12351987
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.01016801
18BP1_19119308_ChIP-ChIP_Hs578T_Human11.7573016
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.98008261
20GATA3_27048872_Chip-Seq_THYMUS_Human1.91370450
21RUNX_20019798_ChIP-Seq_JUKART_Human1.87708925
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.78405582
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77390413
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.74300796
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63460312
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62927696
27GATA3_26560356_Chip-Seq_TH2_Human1.58664409
28MYB_26560356_Chip-Seq_TH1_Human1.56847322
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56682546
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54895292
31VDR_23849224_ChIP-Seq_CD4+_Human1.52924567
32HTT_18923047_ChIP-ChIP_STHdh_Human1.44538202
33UTX_26944678_Chip-Seq_JUKART_Human1.44038948
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40002436
35MAF_26560356_Chip-Seq_TH2_Human1.36405617
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31605731
37PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.30949219
38PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.29900297
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29251249
40TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.23482240
41ZNF274_21170338_ChIP-Seq_K562_Hela1.23111271
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22981190
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.21785684
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21440964
45RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.20741404
46MAF_26560356_Chip-Seq_TH1_Human1.18129559
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16414032
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15436873
49IGF1R_20145208_ChIP-Seq_DFB_Human1.09478474
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.08145158
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08053044
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07996185
53BCL6_27268052_Chip-Seq_Bcells_Human1.06072827
54EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04868147
55MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04689865
56TAF2_19829295_ChIP-Seq_ESCs_Human1.03622984
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.03226854
58FOXP3_21729870_ChIP-Seq_TREG_Human1.01544917
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00940964
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99976205
61SPI1_23547873_ChIP-Seq_NB4_Human0.99816073
62NANOG_20526341_ChIP-Seq_ESCs_Human0.99394526
63PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98617326
64HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95706892
65AR_20517297_ChIP-Seq_VCAP_Human0.94837959
66TP53_22573176_ChIP-Seq_HFKS_Human0.93904486
67BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.93642178
68CTCF_20526341_ChIP-Seq_ESCs_Human0.92041782
69FOXA1_25329375_ChIP-Seq_VCAP_Human0.91633380
70FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91633380
71NFE2_27457419_Chip-Seq_LIVER_Mouse0.91305406
72GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.91058680
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90519307
74AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90369803
75IRF8_27001747_Chip-Seq_BMDM_Mouse0.88431401
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88273415
77GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.86429450
78P300_27268052_Chip-Seq_Bcells_Human0.85306850
79GATA3_26560356_Chip-Seq_TH1_Human0.85043863
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84801257
81ETS1_20019798_ChIP-Seq_JURKAT_Human0.84375300
82YY1_22570637_ChIP-Seq_MALME-3M_Human0.84273266
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83097273
84RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82574429
85FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82313090
86ER_23166858_ChIP-Seq_MCF-7_Human0.82207253
87ERG_20517297_ChIP-Seq_VCAP_Human0.81426904
88FOXH1_21741376_ChIP-Seq_EPCs_Human0.80045822
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79175641
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.78414261
91NANOG_19829295_ChIP-Seq_ESCs_Human0.78082132
92SOX2_19829295_ChIP-Seq_ESCs_Human0.78082132
93SMAD_19615063_ChIP-ChIP_OVARY_Human0.77413717
94GATA6_21074721_ChIP-Seq_CACO-2_Human0.76289944
95NCOR_22424771_ChIP-Seq_293T_Human0.75365986
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.75332798
97FOXH1_21741376_ChIP-Seq_ESCs_Human0.74563357
98RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74300063
99GATA3_21878914_ChIP-Seq_MCF-7_Human0.74069955
100SUZ12_27294783_Chip-Seq_NPCs_Mouse0.74060823

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.93460646
2MP0009785_altered_susceptibility_to3.90115052
3MP0006082_CNS_inflammation3.71192541
4MP0009333_abnormal_splenocyte_physiolog3.37686213
5MP0001835_abnormal_antigen_presentation2.96465113
6MP0001873_stomach_inflammation2.94423967
7MP0005000_abnormal_immune_tolerance2.93929894
8MP0003763_abnormal_thymus_physiology2.91610693
9MP0002148_abnormal_hypersensitivity_rea2.62415716
10MP0003866_abnormal_defecation2.51962047
11MP0001800_abnormal_humoral_immune2.51192124
12MP0002420_abnormal_adaptive_immunity2.49252346
13MP0005025_abnormal_response_to2.48920354
14MP0002723_abnormal_immune_serum2.46902952
15MP0001819_abnormal_immune_cell2.37394206
16MP0002166_altered_tumor_susceptibility2.33579641
17MP0005387_immune_system_phenotype2.32516743
18MP0001790_abnormal_immune_system2.32516743
19MP0002102_abnormal_ear_morphology2.08445696
20MP0002405_respiratory_system_inflammati1.99592418
21MP0010155_abnormal_intestine_physiology1.91899744
22MP0002452_abnormal_antigen_presenting1.91892039
23MP0000716_abnormal_immune_system1.87514093
24MP0003448_altered_tumor_morphology1.79564019
25MP0002876_abnormal_thyroid_physiology1.74312664
26MP0001845_abnormal_inflammatory_respons1.73111342
27MP0002398_abnormal_bone_marrow1.72813644
28MP0002006_tumorigenesis1.69693746
29MP0000685_abnormal_immune_system1.62857729
30MP0002933_joint_inflammation1.51510668
31MP0002419_abnormal_innate_immunity1.50618087
32MP0002722_abnormal_immune_system1.49776799
33MP0000703_abnormal_thymus_morphology1.49694414
34MP0004947_skin_inflammation1.43618932
35MP0001905_abnormal_dopamine_level1.43431449
36MP0000372_irregular_coat_pigmentation1.40381242
37MP0001853_heart_inflammation1.38817306
38MP0001919_abnormal_reproductive_system1.36147524
39MP0002429_abnormal_blood_cell1.35337436
40MP0003786_premature_aging1.34749308
41MP0000689_abnormal_spleen_morphology1.33769038
42MP0002877_abnormal_melanocyte_morpholog1.32684037
43MP0008469_abnormal_protein_level1.29001473
44MP0008995_early_reproductive_senescence1.28875336
45MP0005310_abnormal_salivary_gland1.24637407
46MP0005464_abnormal_platelet_physiology1.24554186
47MP0001984_abnormal_olfaction1.19384259
48MP0005377_hearing/vestibular/ear_phenot1.17175754
49MP0003878_abnormal_ear_physiology1.17175754
50MP0008872_abnormal_physiological_respon1.17051273
51MP0005645_abnormal_hypothalamus_physiol1.15031200
52MP0002277_abnormal_respiratory_mucosa1.14924289
53MP0003436_decreased_susceptibility_to1.13727927
54MP0003137_abnormal_impulse_conducting1.11616212
55MP0001485_abnormal_pinna_reflex1.09519620
56MP0009763_increased_sensitivity_to1.09299271
57MP0001661_extended_life_span1.09013956
58MP0002163_abnormal_gland_morphology1.04915900
59MP0002132_abnormal_respiratory_system1.04161654
60MP0001188_hyperpigmentation1.00054454
61MP0006072_abnormal_retinal_apoptosis0.99730306
62MP0004742_abnormal_vestibular_system0.97182465
63MP0001727_abnormal_embryo_implantation0.97097892
64MP0000858_altered_metastatic_potential0.95250596
65MP0002693_abnormal_pancreas_physiology0.94960002
66MP0005389_reproductive_system_phenotype0.85782789
67MP0009764_decreased_sensitivity_to0.84668632
68MP0005257_abnormal_intraocular_pressure0.83192054
69MP0004134_abnormal_chest_morphology0.82366886
70MP0006035_abnormal_mitochondrial_morpho0.81995665
71MP0003724_increased_susceptibility_to0.81842467
72MP0009697_abnormal_copulation0.78387036
73MP0002837_dystrophic_cardiac_calcinosis0.74184671
74MP0003787_abnormal_imprinting0.73783153
75MP0009745_abnormal_behavioral_response0.72013496
76MP0005253_abnormal_eye_physiology0.70376738
77MP0008873_increased_physiological_sensi0.69705918
78MP0003045_fibrosis0.69336566
79MP0008875_abnormal_xenobiotic_pharmacok0.69224597
80MP0002019_abnormal_tumor_incidence0.68861886
81MP0008877_abnormal_DNA_methylation0.68295916
82MP0010386_abnormal_urinary_bladder0.68061151
83MP0001529_abnormal_vocalization0.67668975
84MP0003195_calcinosis0.66305084
85MP0006036_abnormal_mitochondrial_physio0.65706986
86MP0004145_abnormal_muscle_electrophysio0.64592473
87MP0002733_abnormal_thermal_nociception0.64158829
88MP0008789_abnormal_olfactory_epithelium0.62780534
89MP0005166_decreased_susceptibility_to0.62227437
90MP0003075_altered_response_to0.61836048
91MP0002234_abnormal_pharynx_morphology0.61309684
92MP0001765_abnormal_ion_homeostasis0.59619970
93MP0005636_abnormal_mineral_homeostasis0.59304735
94MP0005551_abnormal_eye_electrophysiolog0.58875197
95MP0004142_abnormal_muscle_tone0.58697818
96MP0005379_endocrine/exocrine_gland_phen0.58011662
97MP0009379_abnormal_foot_pigmentation0.57661356
98MP0009765_abnormal_xenobiotic_induced0.57446700
99MP0001440_abnormal_grooming_behavior0.56500724
100MP0001968_abnormal_touch/_nociception0.55215175

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of T cell number (HP:0011839)6.28407437
2T lymphocytopenia (HP:0005403)6.17972531
3Aplastic anemia (HP:0001915)5.71102953
4Autoimmune hemolytic anemia (HP:0001890)5.49438755
5Hypoproteinemia (HP:0003075)4.55138756
6Increased IgM level (HP:0003496)4.31146029
7Severe combined immunodeficiency (HP:0004430)4.28076148
8Elevated erythrocyte sedimentation rate (HP:0003565)4.10217233
9Abnormality of T cells (HP:0002843)4.08917465
10IgG deficiency (HP:0004315)4.02709143
11Chronic diarrhea (HP:0002028)3.93557372
12Abnormality of eosinophils (HP:0001879)3.86019832
13Abnormality of B cell number (HP:0010975)3.78008723
14Abnormality of macrophages (HP:0004311)3.71951899
15Thyroiditis (HP:0100646)3.68402323
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.63030385
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.63030385
18Eosinophilia (HP:0001880)3.53287015
19Combined immunodeficiency (HP:0005387)3.46479799
20Recurrent bacterial skin infections (HP:0005406)3.40638769
21Autoimmune thrombocytopenia (HP:0001973)3.39307485
22Mitochondrial inheritance (HP:0001427)3.36834448
23Increased intramyocellular lipid droplets (HP:0012240)3.23897194
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.23881662
25Recurrent abscess formation (HP:0002722)3.20989331
26Abnormality of the prostate (HP:0008775)3.14152288
273-Methylglutaconic aciduria (HP:0003535)2.99481145
28Renal Fanconi syndrome (HP:0001994)2.98462689
29Obstructive lung disease (HP:0006536)2.96848045
30Chronic obstructive pulmonary disease (HP:0006510)2.96848045
31Abnormality of cells of the lymphoid lineage (HP:0012140)2.96059672
32Lymphopenia (HP:0001888)2.92892540
33Congenital stationary night blindness (HP:0007642)2.92597210
34Hepatocellular necrosis (HP:0001404)2.92036063
35Leukocytosis (HP:0001974)2.89707881
36Absent rod-and cone-mediated responses on ERG (HP:0007688)2.88102336
37Meningitis (HP:0001287)2.83150340
38Recurrent gram-negative bacterial infections (HP:0005420)2.81421145
39Acute necrotizing encephalopathy (HP:0006965)2.75755500
40Recurrent viral infections (HP:0004429)2.74851401
41Granulocytopenia (HP:0001913)2.72351775
42Encephalitis (HP:0002383)2.71886605
43Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.71305271
44B lymphocytopenia (HP:0010976)2.68457817
45Amyotrophic lateral sclerosis (HP:0007354)2.66850929
46Increased hepatocellular lipid droplets (HP:0006565)2.65272716
47Recurrent fungal infections (HP:0002841)2.61746401
48Increased muscle lipid content (HP:0009058)2.60581898
49Abnormal mitochondria in muscle tissue (HP:0008316)2.59595222
50Hypoalbuminemia (HP:0003073)2.57382466
51Abnormal albumin level (HP:0012116)2.57382466
52Increased CSF lactate (HP:0002490)2.50757945
53Recurrent bronchitis (HP:0002837)2.43683259
54Recurrent skin infections (HP:0001581)2.39067194
55Recurrent cutaneous fungal infections (HP:0011370)2.38884833
56Chronic mucocutaneous candidiasis (HP:0002728)2.38884833
57Pancreatic cysts (HP:0001737)2.38742870
58Hepatic necrosis (HP:0002605)2.35153558
59Mediastinal lymphadenopathy (HP:0100721)2.34042623
60Progressive macrocephaly (HP:0004481)2.33196517
61Retrobulbar optic neuritis (HP:0100654)2.29060096
62Optic neuritis (HP:0100653)2.29060096
63Gangrene (HP:0100758)2.27480050
64Eczematoid dermatitis (HP:0000976)2.26192237
65Abnormality of T cell physiology (HP:0011840)2.25603923
66Pulmonary infiltrates (HP:0002113)2.25142211
67Lipid accumulation in hepatocytes (HP:0006561)2.21852854
68Hypergammaglobulinemia (HP:0010702)2.21418002
69Hemiplegia (HP:0002301)2.21105804
70Abnormality of midbrain morphology (HP:0002418)2.20993672
71Molar tooth sign on MRI (HP:0002419)2.20993672
72Recurrent otitis media (HP:0000403)2.20912308
73Stomatitis (HP:0010280)2.19432317
74Pustule (HP:0200039)2.19049751
75Hemoptysis (HP:0002105)2.17841607
76IgM deficiency (HP:0002850)2.17815653
77Decreased electroretinogram (ERG) amplitude (HP:0000654)2.17621657
78Cerebral edema (HP:0002181)2.12537859
79Stomach cancer (HP:0012126)2.09957548
80Joint swelling (HP:0001386)2.08398512
81Lymphoma (HP:0002665)2.06068728
82Myositis (HP:0100614)2.05982526
83Optic disc pallor (HP:0000543)2.00656274
84Acute encephalopathy (HP:0006846)2.00029405
85Agammaglobulinemia (HP:0004432)1.99197301
86Vasculitis (HP:0002633)1.98220622
87Aplasia/hypoplasia of the uterus (HP:0008684)1.98196200
88Ureteral stenosis (HP:0000071)1.97912745
89Hypoplasia of the thymus (HP:0000778)1.94207769
90Bronchitis (HP:0012387)1.93359143
91Abnormal rod and cone electroretinograms (HP:0008323)1.92744135
92Decreased central vision (HP:0007663)1.89818915
93Abnormality of renal resorption (HP:0011038)1.89258553
94Abnormality of the alveolar ridges (HP:0006477)1.88696062
95Exertional dyspnea (HP:0002875)1.87506690
96Ureteral obstruction (HP:0006000)1.87026765
97Hypoplasia of the uterus (HP:0000013)1.83853040
98Pancytopenia (HP:0001876)1.83502575
99True hermaphroditism (HP:0010459)1.82126918
100Pulmonary embolism (HP:0002204)1.81071167

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.46864235
2TXK6.18609969
3TESK24.30868742
4ZAK3.49450866
5BCKDK3.32302977
6MAP4K12.67573398
7ITK2.39772944
8TLK12.27519069
9TESK12.17788634
10ADRBK22.07795578
11VRK21.78683669
12GRK71.78655947
13MAP3K111.77152419
14LIMK11.69860425
15VRK11.68800591
16PRKCQ1.68426904
17FRK1.66061354
18WNK41.61507718
19MAP3K121.60928039
20FES1.59187773
21MAP4K21.53702812
22MAPKAPK31.51847521
23CSK1.49177348
24TAOK31.48381395
25PINK11.47839795
26BUB11.46455787
27SYK1.43332935
28LCK1.34167151
29GRK11.26995304
30GRK61.26682772
31MST41.25141491
32TEC1.19336401
33PIK3CA1.15508816
34NUAK11.09865959
35TIE10.93196326
36MAP2K60.87099329
37MYLK0.85403709
38LYN0.83018736
39CAMKK20.80794037
40TRPM70.78101964
41TNK20.77644642
42ZAP700.76818376
43ERBB30.69276973
44SCYL20.68616419
45IKBKB0.67979445
46EIF2AK30.66600850
47JAK20.64757785
48BTK0.62895469
49FYN0.61762778
50PDK20.61364159
51DAPK10.59153810
52CSNK1G30.59017883
53ROCK10.58676997
54INSRR0.56584089
55IKBKE0.55689286
56PIM10.55385123
57INSR0.53673809
58CSF1R0.53478801
59IGF1R0.50519463
60CAMKK10.49748967
61JAK30.49271054
62WNK30.49188510
63BCR0.48052531
64PRKCA0.44039732
65RPS6KA40.43620774
66AURKA0.43388040
67OBSCN0.43147927
68TRIM280.41440869
69PIK3CG0.40106767
70PRKCH0.40050319
71PIM20.39696777
72MAP2K70.37990072
73TBK10.37910475
74CAMK2A0.37498673
75MATK0.36563334
76MAP3K50.35758780
77RPS6KA50.35500025
78PRKACA0.34106083
79PAK10.31660874
80CSNK1A1L0.31221637
81KIT0.31005806
82MUSK0.30869203
83FGFR10.29966027
84AKT30.29910587
85MAPK130.29090958
86CSNK1G10.28312587
87ADRBK10.28252455
88ABL20.27991518
89NME10.27719691
90OXSR10.27228997
91SRPK10.24902634
92ACVR1B0.24419985
93PRKCE0.24320728
94CSNK1G20.24141663
95CSNK2A10.23960401
96TYRO30.22299780
97PLK20.21131809
98BLK0.20714521
99ABL10.20437091
100IRAK40.20406674

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.10752617
2Proteasome_Homo sapiens_hsa030504.59839399
3Graft-versus-host disease_Homo sapiens_hsa053323.54205771
4Antigen processing and presentation_Homo sapiens_hsa046123.51954374
5Autoimmune thyroid disease_Homo sapiens_hsa053203.05371577
6Oxidative phosphorylation_Homo sapiens_hsa001903.02181684
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.86653602
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.83361532
9Hematopoietic cell lineage_Homo sapiens_hsa046402.73842557
10T cell receptor signaling pathway_Homo sapiens_hsa046602.72986475
11Parkinsons disease_Homo sapiens_hsa050122.70211635
12Allograft rejection_Homo sapiens_hsa053302.69001326
13Rheumatoid arthritis_Homo sapiens_hsa053232.37603830
14Type I diabetes mellitus_Homo sapiens_hsa049402.15478719
15RNA polymerase_Homo sapiens_hsa030201.99653530
16Salmonella infection_Homo sapiens_hsa051321.89130675
17Alzheimers disease_Homo sapiens_hsa050101.82678254
18Protein export_Homo sapiens_hsa030601.78430959
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.69550356
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.58328030
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.57598625
22Huntingtons disease_Homo sapiens_hsa050161.45859045
23Cardiac muscle contraction_Homo sapiens_hsa042601.41795995
24Measles_Homo sapiens_hsa051621.40808563
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.36234710
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29166925
27Viral myocarditis_Homo sapiens_hsa054161.25635323
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18687820
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14582774
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12552423
31Shigellosis_Homo sapiens_hsa051311.01846597
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01170250
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91972841
34NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91507227
35Nitrogen metabolism_Homo sapiens_hsa009100.85144902
36Caffeine metabolism_Homo sapiens_hsa002320.80371903
37Asthma_Homo sapiens_hsa053100.79652830
38Chemokine signaling pathway_Homo sapiens_hsa040620.79146305
39SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78824800
40Intestinal immune network for IgA production_Homo sapiens_hsa046720.77422763
41Malaria_Homo sapiens_hsa051440.77279341
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74376479
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73248722
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72671933
45Propanoate metabolism_Homo sapiens_hsa006400.71049429
46Phototransduction_Homo sapiens_hsa047440.70631206
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62524101
48Peroxisome_Homo sapiens_hsa041460.56487780
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54907869
50Linoleic acid metabolism_Homo sapiens_hsa005910.54748106
51Pyrimidine metabolism_Homo sapiens_hsa002400.52536038
52Staphylococcus aureus infection_Homo sapiens_hsa051500.50602768
53Homologous recombination_Homo sapiens_hsa034400.49810515
54Systemic lupus erythematosus_Homo sapiens_hsa053220.48577395
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46129327
56Ribosome_Homo sapiens_hsa030100.46103577
57Collecting duct acid secretion_Homo sapiens_hsa049660.45170165
58Apoptosis_Homo sapiens_hsa042100.44967240
59Tryptophan metabolism_Homo sapiens_hsa003800.44669164
60Butanoate metabolism_Homo sapiens_hsa006500.43723741
61Sulfur metabolism_Homo sapiens_hsa009200.43368751
62Pertussis_Homo sapiens_hsa051330.42380722
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41305200
64Osteoclast differentiation_Homo sapiens_hsa043800.40674692
65Herpes simplex infection_Homo sapiens_hsa051680.39614223
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39434026
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.38874013
68TNF signaling pathway_Homo sapiens_hsa046680.37961478
69Epstein-Barr virus infection_Homo sapiens_hsa051690.37059851
70Chemical carcinogenesis_Homo sapiens_hsa052040.35427587
71Prion diseases_Homo sapiens_hsa050200.35036886
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33782905
73Leishmaniasis_Homo sapiens_hsa051400.33260752
74Phagosome_Homo sapiens_hsa041450.32871792
75Purine metabolism_Homo sapiens_hsa002300.32703535
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31208455
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31021587
78Ether lipid metabolism_Homo sapiens_hsa005650.30574220
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.30568724
80RNA degradation_Homo sapiens_hsa030180.30182794
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.30059412
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26855208
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25360736
84HTLV-I infection_Homo sapiens_hsa051660.24905301
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.24732858
86Olfactory transduction_Homo sapiens_hsa047400.24685234
87Nucleotide excision repair_Homo sapiens_hsa034200.22975045
88African trypanosomiasis_Homo sapiens_hsa051430.21459003
89Legionellosis_Homo sapiens_hsa051340.18796581
90Endocytosis_Homo sapiens_hsa041440.17097546
91Fatty acid degradation_Homo sapiens_hsa000710.16332586
92Metabolic pathways_Homo sapiens_hsa011000.16304680
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16272785
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.12862902
95Nicotine addiction_Homo sapiens_hsa050330.12275393
96Retinol metabolism_Homo sapiens_hsa008300.12196120
97Tuberculosis_Homo sapiens_hsa051520.11246538
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.11110364
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10394794
100Regulation of autophagy_Homo sapiens_hsa041400.09971342

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