ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.72693205
2	nonmotile primary cilium assembly (GO:0035058)	5.08413081
3	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.84010725
4	protein K11-linked deubiquitination (GO:0035871)	4.71254970
5	regulation of cilium movement (GO:0003352)	4.23979872
6	indolalkylamine metabolic process (GO:0006586)	3.97982204
7	tryptophan catabolic process (GO:0006569)	3.73682499
8	indole-containing compound catabolic process (GO:0042436)	3.73682499
9	indolalkylamine catabolic process (GO:0046218)	3.73682499
10	protein complex biogenesis (GO:0070271)	3.72730291
11	respiratory chain complex IV assembly (GO:0008535)	3.72708948
12	keratinocyte development (GO:0003334)	3.67995855
13	exocrine pancreas development (GO:0031017)	3.66389960
14	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.64517002
15	substrate-independent telencephalic tangential migration (GO:0021826)	3.64517002
16	peristalsis (GO:0030432)	3.64472554
17	left/right axis specification (GO:0070986)	3.62898308
18	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.61896917
19	NADH dehydrogenase complex assembly (GO:0010257)	3.61896917
20	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.61896917
21	amine catabolic process (GO:0009310)	3.58808609
22	cellular biogenic amine catabolic process (GO:0042402)	3.58808609
23	behavioral response to nicotine (GO:0035095)	3.58008232
24	epithelial cilium movement (GO:0003351)	3.48708177
25	somite development (GO:0061053)	3.42877706
26	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	3.40216737
27	positive regulation of sodium ion transmembrane transport (GO:1902307)	3.38525914
28	proteasome assembly (GO:0043248)	3.35071408
29	chaperone-mediated protein transport (GO:0072321)	3.33555987
30	DNA damage response, detection of DNA damage (GO:0042769)	3.33473074
31	mitochondrial respiratory chain complex assembly (GO:0033108)	3.32359728
32	peptidyl-histidine modification (GO:0018202)	3.32150312
33	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.32051756
34	kynurenine metabolic process (GO:0070189)	3.28875401
35	myoblast migration (GO:0051451)	3.28353470
36	tryptophan metabolic process (GO:0006568)	3.18956577
37	axoneme assembly (GO:0035082)	3.18375421
38	cytochrome complex assembly (GO:0017004)	3.17781545
39	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.15861306
40	phasic smooth muscle contraction (GO:0014821)	3.11675031
41	terpenoid biosynthetic process (GO:0016114)	3.10410257
42	neuron remodeling (GO:0016322)	3.08811264
43	organelle disassembly (GO:1903008)	3.06726377
44	plasma membrane fusion (GO:0045026)	3.06194352
45	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.01007281
46	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.01007281
47	motile cilium assembly (GO:0044458)	2.99585231
48	cerebral cortex radially oriented cell migration (GO:0021799)	2.99148283
49	maturation of 5.8S rRNA (GO:0000460)	2.98761645
50	fucose catabolic process (GO:0019317)	2.97735957
51	L-fucose metabolic process (GO:0042354)	2.97735957
52	L-fucose catabolic process (GO:0042355)	2.97735957
53	aldehyde catabolic process (GO:0046185)	2.92360611
54	rRNA catabolic process (GO:0016075)	2.91596461
55	rRNA methylation (GO:0031167)	2.91229863
56	platelet dense granule organization (GO:0060155)	2.88596428
57	limb bud formation (GO:0060174)	2.86331554
58	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.86263360
59	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.82618716
60	regulation of Rac GTPase activity (GO:0032314)	2.77333536
61	cilium morphogenesis (GO:0060271)	2.77238974
62	DNA deamination (GO:0045006)	2.74818629
63	cilium assembly (GO:0042384)	2.72678440
64	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.72501145
65	ATP synthesis coupled proton transport (GO:0015986)	2.72501145
66	cilium organization (GO:0044782)	2.72439363
67	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.71754158
68	termination of RNA polymerase III transcription (GO:0006386)	2.71754158
69	pyrimidine nucleobase catabolic process (GO:0006208)	2.69984583
70	rRNA modification (GO:0000154)	2.69934469
71	positive regulation of meiosis (GO:0045836)	2.67279808
72	acrosome reaction (GO:0007340)	2.65133387
73	pseudouridine synthesis (GO:0001522)	2.64064644
74	branched-chain amino acid catabolic process (GO:0009083)	2.63184469
75	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.62895761
76	opioid receptor signaling pathway (GO:0038003)	2.62451604
77	piRNA metabolic process (GO:0034587)	2.61998602
78	prenylation (GO:0097354)	2.60864633
79	protein prenylation (GO:0018342)	2.60864633
80	nucleobase catabolic process (GO:0046113)	2.60687837
81	regulation of meiosis I (GO:0060631)	2.60021149
82	protein localization to cilium (GO:0061512)	2.58686722
83	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.57279269
84	water-soluble vitamin biosynthetic process (GO:0042364)	2.57003039
85	S-adenosylmethionine metabolic process (GO:0046500)	2.54759292
86	regulation of microtubule-based movement (GO:0060632)	2.54210908
87	preassembly of GPI anchor in ER membrane (GO:0016254)	2.54021301
88	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.51473409
89	positive regulation of meiotic cell cycle (GO:0051446)	2.49493961
90	cilium movement (GO:0003341)	2.48793871
91	protein-cofactor linkage (GO:0018065)	2.48305777
92	inner ear receptor stereocilium organization (GO:0060122)	2.47034388
93	sperm motility (GO:0030317)	2.45674733
94	protein polyglutamylation (GO:0018095)	2.45133470
95	intraciliary transport (GO:0042073)	2.43592753
96	presynaptic membrane assembly (GO:0097105)	2.43411373
97	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.43114008
98	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.42031396
99	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	2.40246825
100	maturation of SSU-rRNA (GO:0030490)	2.39300704

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RBPJ_22232070_ChIP-Seq_NCS_Mouse	4.08461448
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.36339229
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.26773594
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.18052603
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.79708951
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.68872997
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.49548499
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.44722556
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.43130116
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.33919353
11	EWS_26573619_Chip-Seq_HEK293_Human	2.20662981
12	VDR_22108803_ChIP-Seq_LS180_Human	2.17014606
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.12193322
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.11057612
15	P300_19829295_ChIP-Seq_ESCs_Human	2.08644934
16	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.03902275
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.00826141
18	IGF1R_20145208_ChIP-Seq_DFB_Human	1.99178069
19	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.97163627
20	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.92942836
21	FUS_26573619_Chip-Seq_HEK293_Human	1.92675033
22	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.87676080
23	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.85915314
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.85484267
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.80620436
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.75594395
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.73551624
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.70297691
29	TP53_16413492_ChIP-PET_HCT116_Human	1.67713667
30	EZH2_22144423_ChIP-Seq_EOC_Human	1.65963572
31	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.63766908
32	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.61467283
33	TAF15_26573619_Chip-Seq_HEK293_Human	1.58761423
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.57100778
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.51374502
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.51138218
37	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.48422322
38	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.47662088
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46557352
40	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.45322213
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.44771324
42	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.44065333
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44065333
44	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.42962843
45	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.40806548
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.39945903
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.39628782
48	STAT3_23295773_ChIP-Seq_U87_Human	1.37788312
49	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36330441
50	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.31770156
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.30939567
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.30939567
53	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.30319242
54	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.28774877
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.28536460
56	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.28471957
57	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.28011100
58	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.27931604
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.27848249
60	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.27696417
61	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27205464
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26083923
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26083923
64	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.25439846
65	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.25153754
66	SMAD4_21799915_ChIP-Seq_A2780_Human	1.24399764
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24091397
68	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.23381837
69	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.22958178
70	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.21638225
71	AR_25329375_ChIP-Seq_VCAP_Human	1.20349214
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.19536427
73	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.17288982
74	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.13037144
75	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.12754119
76	MYC_18940864_ChIP-ChIP_HL60_Human	1.12598826
77	RNF2_27304074_Chip-Seq_NSC_Mouse	1.12206003
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10912412
79	P53_22387025_ChIP-Seq_ESCs_Mouse	1.09716319
80	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.09678706
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09547846
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.09050063
83	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.05128197
84	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.04972997
85	CDX2_22108803_ChIP-Seq_LS180_Human	1.04731909
86	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.04579863
87	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.04483729
88	TCF4_23295773_ChIP-Seq_U87_Human	1.04190215
89	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.03408088
90	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.03380124
91	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02738344
92	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02738344
93	RUNX2_22187159_ChIP-Seq_PCA_Human	1.01681593
94	TP53_18474530_ChIP-ChIP_U2OS_Human	1.00595684
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.00347687
96	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99411322
97	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.98789844
98	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.97723781
99	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.97516061
100	VDR_23849224_ChIP-Seq_CD4+_Human	0.96307145

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003950_abnormal_plasma_membrane	3.46652701
2	MP0003787_abnormal_imprinting	2.82247237
3	MP0008789_abnormal_olfactory_epithelium	2.75029229
4	MP0008877_abnormal_DNA_methylation	2.70636279
5	MP0001986_abnormal_taste_sensitivity	2.64383690
6	MP0005084_abnormal_gallbladder_morpholo	2.58837527
7	MP0006292_abnormal_olfactory_placode	2.56879508
8	MP0002102_abnormal_ear_morphology	2.43678477
9	MP0005551_abnormal_eye_electrophysiolog	2.36877233
10	MP0004147_increased_porphyrin_level	2.19805981
11	MP0002736_abnormal_nociception_after	2.17666813
12	MP0003122_maternal_imprinting	2.13170291
13	MP0003195_calcinosis	2.04263475
14	MP0001968_abnormal_touch/_nociception	1.95338724
15	MP0000516_abnormal_urinary_system	1.87975083
16	MP0005367_renal/urinary_system_phenotyp	1.87975083
17	MP0006072_abnormal_retinal_apoptosis	1.87948027
18	MP0003121_genomic_imprinting	1.78534551
19	MP0000749_muscle_degeneration	1.74507891
20	MP0003880_abnormal_central_pattern	1.71906873
21	MP0004270_analgesia	1.68841442
22	MP0008775_abnormal_heart_ventricle	1.68713843
23	MP0005394_taste/olfaction_phenotype	1.64208503
24	MP0005499_abnormal_olfactory_system	1.64208503
25	MP0002233_abnormal_nose_morphology	1.59042984
26	MP0006276_abnormal_autonomic_nervous	1.58480560
27	MP0003786_premature_aging	1.56300729
28	MP0000778_abnormal_nervous_system	1.55494353
29	MP0002234_abnormal_pharynx_morphology	1.52385916
30	MP0005167_abnormal_blood-brain_barrier	1.48169444
31	MP0005253_abnormal_eye_physiology	1.47948660
32	MP0002734_abnormal_mechanical_nocicepti	1.47183000
33	MP0000538_abnormal_urinary_bladder	1.46720144
34	MP0008872_abnormal_physiological_respon	1.44463922
35	MP0003718_maternal_effect	1.43725336
36	MP0002163_abnormal_gland_morphology	1.41852683
37	MP0001529_abnormal_vocalization	1.41759604
38	MP0005083_abnormal_biliary_tract	1.39428488
39	MP0009046_muscle_twitch	1.38528133
40	MP0004142_abnormal_muscle_tone	1.37745027
41	MP0009697_abnormal_copulation	1.36666434
42	MP0005379_endocrine/exocrine_gland_phen	1.36047555
43	MP0001293_anophthalmia	1.35433305
44	MP0010030_abnormal_orbit_morphology	1.35345936
45	MP0000372_irregular_coat_pigmentation	1.35303719
46	MP0003942_abnormal_urinary_system	1.33184578
47	MP0000613_abnormal_salivary_gland	1.30714087
48	MP0010386_abnormal_urinary_bladder	1.30518932
49	MP0008995_early_reproductive_senescence	1.30509186
50	MP0001984_abnormal_olfaction	1.28775005
51	MP0009379_abnormal_foot_pigmentation	1.24502547
52	MP0000569_abnormal_digit_pigmentation	1.24396116
53	MP0008058_abnormal_DNA_repair	1.23638898
54	MP0002184_abnormal_innervation	1.22160280
55	MP0005645_abnormal_hypothalamus_physiol	1.19646807
56	MP0003937_abnormal_limbs/digits/tail_de	1.18724725
57	MP0005220_abnormal_exocrine_pancreas	1.18501667
58	MP0000631_abnormal_neuroendocrine_gland	1.17858685
59	MP0005195_abnormal_posterior_eye	1.17719550
60	MP0002733_abnormal_thermal_nociception	1.15969766
61	MP0000534_abnormal_ureter_morphology	1.15964293
62	MP0002735_abnormal_chemical_nociception	1.14023043
63	MP0004742_abnormal_vestibular_system	1.12400795
64	MP0002752_abnormal_somatic_nervous	1.10701754
65	MP0002638_abnormal_pupillary_reflex	1.10478561
66	MP0002837_dystrophic_cardiac_calcinosis	1.08834169
67	MP0002272_abnormal_nervous_system	1.08077131
68	MP0001501_abnormal_sleep_pattern	1.07058105
69	MP0001970_abnormal_pain_threshold	1.04143595
70	MP0003385_abnormal_body_wall	1.03490070
71	MP0004215_abnormal_myocardial_fiber	1.03421590
72	MP0004133_heterotaxia	1.02877082
73	MP0000427_abnormal_hair_cycle	1.00973742
74	MP0009384_cardiac_valve_regurgitation	0.97941498
75	MP0002938_white_spotting	0.97664767
76	MP0008057_abnormal_DNA_replication	0.96970151
77	MP0002751_abnormal_autonomic_nervous	0.93517137
78	MP0002282_abnormal_trachea_morphology	0.91990894
79	MP0004924_abnormal_behavior	0.91590404
80	MP0005386_behavior/neurological_phenoty	0.91590404
81	MP0005248_abnormal_Harderian_gland	0.89725304
82	MP0004084_abnormal_cardiac_muscle	0.89582124
83	MP0001486_abnormal_startle_reflex	0.89440564
84	MP0001299_abnormal_eye_distance/	0.88405344
85	MP0003567_abnormal_fetal_cardiomyocyte	0.87745688
86	MP0004085_abnormal_heartbeat	0.86318553
87	MP0000647_abnormal_sebaceous_gland	0.85123352
88	MP0001286_abnormal_eye_development	0.85092503
89	MP0005410_abnormal_fertilization	0.84312351
90	MP0002138_abnormal_hepatobiliary_system	0.80880119
91	MP0003755_abnormal_palate_morphology	0.79400068
92	MP0005187_abnormal_penis_morphology	0.79391446
93	MP0002067_abnormal_sensory_capabilities	0.79252651
94	MP0001485_abnormal_pinna_reflex	0.78848238
95	MP0003186_abnormal_redox_activity	0.78682644
96	MP0002557_abnormal_social/conspecific_i	0.78375271
97	MP0000049_abnormal_middle_ear	0.78222797
98	MP0009053_abnormal_anal_canal	0.78118965
99	MP0001177_atelectasis	0.76209841
100	MP0000230_abnormal_systemic_arterial	0.74835596

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.71144164
2	Molar tooth sign on MRI (HP:0002419)	4.56904434
3	Abnormality of midbrain morphology (HP:0002418)	4.56904434
4	Renal Fanconi syndrome (HP:0001994)	3.66935543
5	Pancreatic fibrosis (HP:0100732)	3.42191842
6	Hyperventilation (HP:0002883)	3.38146431
7	Medial flaring of the eyebrow (HP:0010747)	3.33825538
8	Nephronophthisis (HP:0000090)	3.30676178
9	Pancreatic cysts (HP:0001737)	3.30559595
10	Proximal tubulopathy (HP:0000114)	3.27014070
11	Progressive macrocephaly (HP:0004481)	3.19329341
12	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.13470104
13	Acute necrotizing encephalopathy (HP:0006965)	3.12573959
14	True hermaphroditism (HP:0010459)	3.09281936
15	Absent/shortened dynein arms (HP:0200106)	3.04217085
16	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.04217085
17	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.97049896
18	Increased corneal curvature (HP:0100692)	2.90555617
19	Keratoconus (HP:0000563)	2.90555617
20	Pendular nystagmus (HP:0012043)	2.80206535
21	Acute encephalopathy (HP:0006846)	2.75582763
22	Genital tract atresia (HP:0001827)	2.68453587
23	Osteomalacia (HP:0002749)	2.64651318
24	Abnormal mitochondria in muscle tissue (HP:0008316)	2.63003142
25	Abnormality of the renal medulla (HP:0100957)	2.61758897
26	Increased CSF lactate (HP:0002490)	2.59784365
27	Mitochondrial inheritance (HP:0001427)	2.59223234
28	Congenital primary aphakia (HP:0007707)	2.56406037
29	Abnormality of renal resorption (HP:0011038)	2.56122895
30	Small hand (HP:0200055)	2.53908453
31	Gait imbalance (HP:0002141)	2.46624093
32	Abnormal rod and cone electroretinograms (HP:0008323)	2.44358850
33	Vaginal atresia (HP:0000148)	2.42084761
34	Optic nerve hypoplasia (HP:0000609)	2.41991604
35	Aplasia of the musculature (HP:0100854)	2.35870075
36	Pachygyria (HP:0001302)	2.34741665
37	Type 2 muscle fiber atrophy (HP:0003554)	2.34375185
38	Decreased central vision (HP:0007663)	2.26394127
39	Anencephaly (HP:0002323)	2.25531727
40	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.24423214
41	Mesomelia (HP:0003027)	2.23983584
42	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.22937231
43	Abnormal respiratory motile cilium morphology (HP:0005938)	2.20301018
44	Abnormal respiratory epithelium morphology (HP:0012253)	2.20301018
45	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.12643084
46	Type II lissencephaly (HP:0007260)	2.11491655
47	Severe muscular hypotonia (HP:0006829)	2.11342519
48	Increased hepatocellular lipid droplets (HP:0006565)	2.10482296
49	Megalencephaly (HP:0001355)	2.07796301
50	Methylmalonic acidemia (HP:0002912)	2.06467646
51	Colon cancer (HP:0003003)	2.06407433
52	Increased serum lactate (HP:0002151)	2.06402248
53	Abnormality of the renal cortex (HP:0011035)	2.05579546
54	Lipid accumulation in hepatocytes (HP:0006561)	2.04823609
55	Nephrogenic diabetes insipidus (HP:0009806)	2.04747366
56	Hypothermia (HP:0002045)	2.02020899
57	Tongue fasciculations (HP:0001308)	1.99919106
58	Cystic liver disease (HP:0006706)	1.97214586
59	CNS hypomyelination (HP:0003429)	1.96574191
60	Postaxial hand polydactyly (HP:0001162)	1.94997239
61	Congenital, generalized hypertrichosis (HP:0004540)	1.94796919
62	Short chin (HP:0000331)	1.94607654
63	Aplasia/Hypoplasia of the lens (HP:0008063)	1.94221686
64	Chronic bronchitis (HP:0004469)	1.93508292
65	Chronic hepatic failure (HP:0100626)	1.92466431
66	Bifid tongue (HP:0010297)	1.90935095
67	Amniotic constriction ring (HP:0009775)	1.89804461
68	Abnormality of placental membranes (HP:0011409)	1.89804461
69	Increased serum pyruvate (HP:0003542)	1.87680919
70	Chorioretinal atrophy (HP:0000533)	1.86728520
71	Abnormal ciliary motility (HP:0012262)	1.84465568
72	Postaxial foot polydactyly (HP:0001830)	1.84053421
73	Constricted visual fields (HP:0001133)	1.80716803
74	Abnormality of glycolysis (HP:0004366)	1.79930430
75	Congenital hepatic fibrosis (HP:0002612)	1.78373699
76	Muscle fiber atrophy (HP:0100295)	1.78292790
77	Optic disc pallor (HP:0000543)	1.78259658
78	Widely spaced teeth (HP:0000687)	1.78053717
79	Stenosis of the external auditory canal (HP:0000402)	1.77959221
80	Delayed gross motor development (HP:0002194)	1.75425518
81	Congenital stationary night blindness (HP:0007642)	1.74978915
82	Absent speech (HP:0001344)	1.73860245
83	Cerebral edema (HP:0002181)	1.73803880
84	Ulnar claw (HP:0001178)	1.73039599
85	Exotropia (HP:0000577)	1.71377669
86	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.71016306
87	Methylmalonic aciduria (HP:0012120)	1.70439766
88	Hyperphosphaturia (HP:0003109)	1.70120363
89	Hypophosphatemic rickets (HP:0004912)	1.70102789
90	Lactic acidosis (HP:0003128)	1.69476545
91	Tubular atrophy (HP:0000092)	1.68071546
92	Dyskinesia (HP:0100660)	1.68048332
93	Disproportionate short-trunk short stature (HP:0003521)	1.67239635
94	Large for gestational age (HP:0001520)	1.66729405
95	Abnormal respiratory motile cilium physiology (HP:0012261)	1.66650414
96	Posterior subcapsular cataract (HP:0007787)	1.65727209
97	Metaphyseal dysplasia (HP:0100255)	1.64571583
98	Reticulocytopenia (HP:0001896)	1.64493711
99	Intestinal atresia (HP:0011100)	1.64080676
100	Glycosuria (HP:0003076)	1.63979018

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NEK1	5.69050386
2	FRK	3.89238464
3	GRK1	3.68425714
4	NUAK1	2.95542279
5	MST4	2.90659173
6	MAP4K2	2.89677008
7	ADRBK2	2.67456233
8	EIF2AK1	2.47463896
9	AKT3	2.36843536
10	TRIM28	2.17526569
11	WNK3	2.09543643
12	BCR	1.98549912
13	EIF2AK3	1.86239180
14	ERBB3	1.80065923
15	PLK2	1.72784813
16	PIM2	1.57858954
17	MKNK2	1.51419689
18	PLK4	1.49699985
19	BMPR1B	1.47676366
20	MARK1	1.43781117
21	CCNB1	1.35046679
22	CSNK1A1L	1.33224713
23	BCKDK	1.31870854
24	CSNK1G1	1.29681282
25	CSNK1G3	1.28518413
26	TIE1	1.28413027
27	DYRK2	1.21369978
28	FER	1.20869095
29	PAK3	1.19479620
30	TGFBR2	1.17025801
31	CSNK1G2	1.16702310
32	CASK	1.13226508
33	LIMK1	1.11847516
34	PINK1	1.11171390
35	BRSK2	1.07016120
36	TEC	1.06200891
37	MAPK13	1.06053080
38	EPHA4	1.04473030
39	TAOK3	1.00848773
40	STK39	0.98586368
41	VRK2	0.96512140
42	SRPK1	0.94356671
43	MINK1	0.91875593
44	INSRR	0.90681433
45	PRKCE	0.89267672
46	PLK3	0.87019293
47	MKNK1	0.85022449
48	NTRK3	0.84461536
49	OXSR1	0.82372790
50	PIK3CA	0.81948720
51	ADRBK1	0.78330505
52	TAF1	0.78009387
53	TNIK	0.76904765
54	STK3	0.72664284
55	MAP3K12	0.71382227
56	WNK4	0.67655937
57	KSR1	0.66792214
58	OBSCN	0.66290235
59	ROCK1	0.63635437
60	STK16	0.61595588
61	ACVR1B	0.60712827
62	NEK2	0.60020808
63	PDK2	0.59681760
64	MYLK	0.57616449
65	DAPK3	0.56736098
66	PRKCI	0.56315766
67	MAPKAPK5	0.54439406
68	ZAK	0.54148649
69	CDK19	0.53106479
70	FGFR1	0.47575164
71	TGFBR1	0.47012843
72	GRK5	0.46887180
73	PRKCG	0.45469041
74	NME2	0.44563287
75	AURKB	0.43391759
76	STK38	0.42758215
77	CAMKK2	0.42678730
78	LATS1	0.41873865
79	DYRK3	0.40878141
80	EIF2AK2	0.40012381
81	KIT	0.37407972
82	WEE1	0.36832007
83	PRKCQ	0.36055669
84	DAPK2	0.35913612
85	ROCK2	0.35381369
86	IRAK1	0.34529485
87	CAMK1	0.34159590
88	PRKCZ	0.33980778
89	FLT3	0.32502787
90	EPHB2	0.32139904
91	FGFR2	0.32099753
92	MET	0.30946651
93	IGF1R	0.30471244
94	PAK2	0.30442967
95	MAP3K4	0.30031837
96	CSNK1A1	0.30025402
97	TRPM7	0.29889077
98	PRKACA	0.29720814
99	BRSK1	0.29352663
100	VRK1	0.29145569

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.13317030
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.90883214
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.84093115
4	Propanoate metabolism_Homo sapiens_hsa00640	2.74440435
5	Proteasome_Homo sapiens_hsa03050	2.66768683
6	Parkinsons disease_Homo sapiens_hsa05012	2.65215041
7	Butanoate metabolism_Homo sapiens_hsa00650	2.50223684
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.46091272
9	RNA polymerase_Homo sapiens_hsa03020	2.45107896
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.26688308
11	Protein export_Homo sapiens_hsa03060	2.25236081
12	Ribosome_Homo sapiens_hsa03010	2.16843005
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.16162048
14	Caffeine metabolism_Homo sapiens_hsa00232	2.11423467
15	Tryptophan metabolism_Homo sapiens_hsa00380	2.07065590
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.88883619
17	Fatty acid elongation_Homo sapiens_hsa00062	1.86944087
18	RNA degradation_Homo sapiens_hsa03018	1.79163248
19	Basal transcription factors_Homo sapiens_hsa03022	1.78047944
20	Huntingtons disease_Homo sapiens_hsa05016	1.73797689
21	One carbon pool by folate_Homo sapiens_hsa00670	1.72985350
22	Phototransduction_Homo sapiens_hsa04744	1.65956318
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.61040435
24	Peroxisome_Homo sapiens_hsa04146	1.59660765
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.58978362
26	Alzheimers disease_Homo sapiens_hsa05010	1.55568436
27	Steroid biosynthesis_Homo sapiens_hsa00100	1.40622503
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.36795875
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.28862309
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.28450693
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.25268149
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.23129303
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.22997243
34	Olfactory transduction_Homo sapiens_hsa04740	1.21079904
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.18217723
36	Cardiac muscle contraction_Homo sapiens_hsa04260	1.14724276
37	Fatty acid degradation_Homo sapiens_hsa00071	1.13562256
38	Homologous recombination_Homo sapiens_hsa03440	1.03625395
39	p53 signaling pathway_Homo sapiens_hsa04115	1.02069023
40	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.01528096
41	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.00768811
42	Fatty acid metabolism_Homo sapiens_hsa01212	0.99493334
43	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99456300
44	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.99216529
45	Nicotine addiction_Homo sapiens_hsa05033	0.94171607
46	Chemical carcinogenesis_Homo sapiens_hsa05204	0.91723118
47	Mineral absorption_Homo sapiens_hsa04978	0.90751041
48	Regulation of autophagy_Homo sapiens_hsa04140	0.90136703
49	Pyruvate metabolism_Homo sapiens_hsa00620	0.89356984
50	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.88844017
51	Purine metabolism_Homo sapiens_hsa00230	0.87705941
52	Morphine addiction_Homo sapiens_hsa05032	0.86263848
53	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.86012017
54	Metabolic pathways_Homo sapiens_hsa01100	0.83816315
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78706378
56	Non-homologous end-joining_Homo sapiens_hsa03450	0.76209479
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.74433232
58	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.74331898
59	Fat digestion and absorption_Homo sapiens_hsa04975	0.74328068
60	Tight junction_Homo sapiens_hsa04530	0.74255576
61	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.73119840
62	Salivary secretion_Homo sapiens_hsa04970	0.71908585
63	RNA transport_Homo sapiens_hsa03013	0.69029703
64	Retinol metabolism_Homo sapiens_hsa00830	0.67319713
65	Glutathione metabolism_Homo sapiens_hsa00480	0.67031220
66	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.66339001
67	Glycerolipid metabolism_Homo sapiens_hsa00561	0.65893628
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64062594
69	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.63213199
70	GABAergic synapse_Homo sapiens_hsa04727	0.62354904
71	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.59675229
72	Glutamatergic synapse_Homo sapiens_hsa04724	0.58791634
73	Taste transduction_Homo sapiens_hsa04742	0.58691965
74	Nucleotide excision repair_Homo sapiens_hsa03420	0.55740950
75	Asthma_Homo sapiens_hsa05310	0.55712867
76	Pyrimidine metabolism_Homo sapiens_hsa00240	0.54865820
77	Folate biosynthesis_Homo sapiens_hsa00790	0.52990286
78	Arginine and proline metabolism_Homo sapiens_hsa00330	0.51611363
79	Circadian entrainment_Homo sapiens_hsa04713	0.51520288
80	Base excision repair_Homo sapiens_hsa03410	0.50628531
81	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.49018284
82	Hippo signaling pathway_Homo sapiens_hsa04390	0.47675426
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.42897204
84	Serotonergic synapse_Homo sapiens_hsa04726	0.41900476
85	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.41402600
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40332301
87	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.39262462
88	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.38184815
89	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.36626636
90	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.36260810
91	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.36244096
92	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.35953695
93	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.34662789
94	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.34657521
95	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.31127467
96	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.30670379
97	Histidine metabolism_Homo sapiens_hsa00340	0.30242278
98	Gastric acid secretion_Homo sapiens_hsa04971	0.29638458
99	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.28457241
100	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.27958304

TXNP6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »