TXNRD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to endosome (GO:0036010)4.68094440
2polyketide metabolic process (GO:0030638)4.60553918
3doxorubicin metabolic process (GO:0044598)4.60553918
4daunorubicin metabolic process (GO:0044597)4.60553918
5low-density lipoprotein particle clearance (GO:0034383)4.28540929
6folic acid-containing compound biosynthetic process (GO:0009396)4.13370307
7skin morphogenesis (GO:0043589)4.12925949
8aminoglycoside antibiotic metabolic process (GO:0030647)4.00170053
9epithelial cell-cell adhesion (GO:0090136)3.57375176
10mitotic chromosome condensation (GO:0007076)3.56359020
11membrane raft organization (GO:0031579)3.47419060
12heterochromatin organization (GO:0070828)3.39804612
13protein hydroxylation (GO:0018126)3.38020414
14maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.34984687
15positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.33075075
16regulation of early endosome to late endosome transport (GO:2000641)3.32931655
17nuclear pore complex assembly (GO:0051292)3.31343756
18retina vasculature morphogenesis in camera-type eye (GO:0061299)3.29953379
19cell adhesion mediated by integrin (GO:0033627)3.28594153
20hypotonic response (GO:0006971)3.25708085
21ribosome assembly (GO:0042255)3.21912152
22nuclear pore organization (GO:0006999)3.20863186
23glucose catabolic process (GO:0006007)3.20860884
24COPII vesicle coating (GO:0048208)3.18757068
25positive regulation of chemokine biosynthetic process (GO:0045080)3.15895745
26membrane protein ectodomain proteolysis (GO:0006509)3.14023601
27L-alpha-amino acid transmembrane transport (GO:1902475)3.12981644
28substrate-dependent cell migration (GO:0006929)3.11370756
29positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.07173107
30cellular protein complex localization (GO:0034629)3.07080006
31hemidesmosome assembly (GO:0031581)3.06537283
32iron ion import (GO:0097286)3.03773207
33regulation of integrin activation (GO:0033623)3.01202243
34protein retention in ER lumen (GO:0006621)3.01077628
35dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.99071706
36cell-substrate junction assembly (GO:0007044)2.98212260
37wound healing, spreading of epidermal cells (GO:0035313)2.97955760
38endothelial cell morphogenesis (GO:0001886)2.96826293
39stress fiber assembly (GO:0043149)2.96560425
40tetrahydrofolate metabolic process (GO:0046653)2.95525876
41hyaluronan catabolic process (GO:0030214)2.94600935
42vesicle coating (GO:0006901)2.94274751
43regulation of cholesterol storage (GO:0010885)2.94042269
44retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.93571292
45mesodermal cell differentiation (GO:0048333)2.93402209
46regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.93136713
47cellular response to vitamin D (GO:0071305)2.92133781
48mammary gland epithelial cell proliferation (GO:0033598)2.90641509
49glycoside metabolic process (GO:0016137)2.90468295
50myeloid cell homeostasis (GO:0002262)2.90326850
51regulation of translational fidelity (GO:0006450)2.89638079
52barbed-end actin filament capping (GO:0051016)2.87157827
53regulation of membrane protein ectodomain proteolysis (GO:0051043)2.86902801
54apoptotic cell clearance (GO:0043277)2.83450344
55positive regulation of extracellular matrix organization (GO:1903055)2.83243285
56regulation of gene silencing by RNA (GO:0060966)2.83213677
57regulation of posttranscriptional gene silencing (GO:0060147)2.83213677
58regulation of gene silencing by miRNA (GO:0060964)2.83213677
59* nucleobase-containing small molecule interconversion (GO:0015949)2.81338661
60DNA unwinding involved in DNA replication (GO:0006268)2.80545678
61T cell apoptotic process (GO:0070231)2.79084307
62focal adhesion assembly (GO:0048041)2.73494522
63cell-substrate adherens junction assembly (GO:0007045)2.73494522
64glucose 6-phosphate metabolic process (GO:0051156)2.72987958
65endoplasmic reticulum unfolded protein response (GO:0030968)2.72724213
66positive regulation of p38MAPK cascade (GO:1900745)2.72029212
67mitotic cytokinesis (GO:0000281)2.71158954
68cytoskeleton-dependent cytokinesis (GO:0061640)2.69056224
69pinocytosis (GO:0006907)2.68531832
70negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.68175711
71positive regulation of interferon-alpha production (GO:0032727)2.67871819
72adherens junction assembly (GO:0034333)2.67821597
73modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.67429675
74positive regulation by organism of defense response of other organism involved in symbiotic interact2.67429675
75modulation by symbiont of host immune response (GO:0052553)2.67429675
76positive regulation by symbiont of host defense response (GO:0052509)2.67429675
77modulation by symbiont of host defense response (GO:0052031)2.67429675
78modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.67429675
79protein localization to microtubule (GO:0035372)2.67155889
80regulation of podosome assembly (GO:0071801)2.66434516
81regulation of cholesterol homeostasis (GO:2000188)2.64682186
82ER-nucleus signaling pathway (GO:0006984)2.64541947
83mRNA stabilization (GO:0048255)2.64419410
84RNA stabilization (GO:0043489)2.64419410
85regulation of hippo signaling (GO:0035330)2.64227906
86IMP biosynthetic process (GO:0006188)2.63845553
87regulation of translational termination (GO:0006449)2.63827245
88cellular response to vitamin (GO:0071295)2.63568175
89positive regulation of SMAD protein import into nucleus (GO:0060391)2.62648134
90basement membrane organization (GO:0071711)2.62643970
91activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.60769609
92mitotic metaphase plate congression (GO:0007080)2.60411395
93activation of Rac GTPase activity (GO:0032863)2.59303012
94cytoskeletal anchoring at plasma membrane (GO:0007016)2.58227306
95apoptotic process involved in morphogenesis (GO:0060561)2.55890341
96natural killer cell mediated immunity (GO:0002228)2.55426880
97natural killer cell mediated cytotoxicity (GO:0042267)2.55426880
98negative regulation of anoikis (GO:2000811)2.55103467
99positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.54314072
100regulation of interferon-alpha production (GO:0032647)2.53915265
101maternal placenta development (GO:0001893)2.53536570
102regulation of mitotic spindle organization (GO:0060236)2.53503101
103positive regulation of nuclease activity (GO:0032075)2.53347817
104protein complex localization (GO:0031503)2.53162442
105negative regulation of protein localization to plasma membrane (GO:1903077)2.52248792
106regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.52094233
107cellular response to unfolded protein (GO:0034620)2.52018139
108glycosphingolipid catabolic process (GO:0046479)2.51857947
109plasma lipoprotein particle clearance (GO:0034381)2.51326371
110peptidyl-proline hydroxylation (GO:0019511)2.49896075
111hippo signaling (GO:0035329)2.49348957
112nucleotide-sugar biosynthetic process (GO:0009226)2.48821415
113dosage compensation (GO:0007549)2.48528940
114negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.48085928
115mitotic nuclear envelope disassembly (GO:0007077)2.47390425
116NLS-bearing protein import into nucleus (GO:0006607)2.47263263
117regulation of heterotypic cell-cell adhesion (GO:0034114)2.46124777
118ER overload response (GO:0006983)2.45017851
119hepatocyte differentiation (GO:0070365)2.44983367
120mitotic sister chromatid segregation (GO:0000070)2.44778905
121pre-miRNA processing (GO:0031054)2.44316855
122establishment of integrated proviral latency (GO:0075713)2.43640408
123protein localization to chromosome, centromeric region (GO:0071459)2.42308150
124response to peptidoglycan (GO:0032494)2.42187116
125positive regulation of osteoblast proliferation (GO:0033690)2.41650952
126glycolipid catabolic process (GO:0019377)2.40981526
127UDP-N-acetylglucosamine metabolic process (GO:0006047)2.40218659
128protein maturation by protein folding (GO:0022417)2.39333012
129nuclear envelope disassembly (GO:0051081)2.39029656
130membrane disassembly (GO:0030397)2.39029656
131regulation of protein export from nucleus (GO:0046825)2.38538983
132embryonic process involved in female pregnancy (GO:0060136)2.38511771
133response to arsenic-containing substance (GO:0046685)2.38491618
1343-UTR-mediated mRNA stabilization (GO:0070935)2.37600860
135IMP metabolic process (GO:0046040)2.37024167
136protein localization to kinetochore (GO:0034501)2.36961958
137positive regulation of protein import into nucleus, translocation (GO:0033160)2.36080833
138regulation of chemokine biosynthetic process (GO:0045073)2.35818305
139pentose-phosphate shunt (GO:0006098)2.34747621
140regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.34661787
141pore complex assembly (GO:0046931)2.33661674
142regulation of SMAD protein import into nucleus (GO:0060390)2.32245386
143positive regulation of lipid storage (GO:0010884)2.32053380
144macroautophagy (GO:0016236)2.29549783
145endodermal cell differentiation (GO:0035987)2.28340865
146hydrogen peroxide biosynthetic process (GO:0050665)2.27874444
147B cell mediated immunity (GO:0019724)2.27402332
148antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.25141667
149cysteine metabolic process (GO:0006534)2.23386873
150epithelial cell differentiation involved in prostate gland development (GO:0060742)2.22634398
151negative regulation of fatty acid transport (GO:2000192)2.22367716
152lymphocyte apoptotic process (GO:0070227)2.22187211
153negative regulation of interleukin-12 production (GO:0032695)2.21853757
154COPI coating of Golgi vesicle (GO:0048205)2.21400023
155Golgi transport vesicle coating (GO:0048200)2.21400023
156negative regulation of fibrinolysis (GO:0051918)2.21209007
157positive regulation of endothelial cell apoptotic process (GO:2000353)2.20871589
158wound healing, spreading of cells (GO:0044319)2.20825383
159response to laminar fluid shear stress (GO:0034616)2.20720410
160regulation of protein heterodimerization activity (GO:0043497)2.20333907
161pteridine-containing compound biosynthetic process (GO:0042559)2.20153873
162chromatin assembly (GO:0031497)2.19564203
163response to UV-C (GO:0010225)2.19417105
164developmental programmed cell death (GO:0010623)2.19406666
165NADPH regeneration (GO:0006740)2.18403130
166positive regulation of protein oligomerization (GO:0032461)2.17663931
167leukocyte apoptotic process (GO:0071887)2.17234190
168negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.15684435
169regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.15450706
170positive regulation of interferon-beta production (GO:0032728)2.14504927
171immunoglobulin mediated immune response (GO:0016064)2.14432713
172acute-phase response (GO:0006953)2.14129387
173regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.13438816
174regulation of interleukin-12 biosynthetic process (GO:0045075)2.13301916
175regulation of vitamin D biosynthetic process (GO:0060556)2.12252730
176positive regulation vascular endothelial growth factor production (GO:0010575)2.11594005
177response to muramyl dipeptide (GO:0032495)2.10860622
178folic acid-containing compound metabolic process (GO:0006760)2.10524336

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.05524289
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.17912362
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.55443891
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.53640291
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.94234852
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.67969664
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.26178610
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.22399839
9MYC_22102868_ChIP-Seq_BL_Human2.13762151
10CLOCK_20551151_ChIP-Seq_293T_Human2.00875870
11* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.00149814
12MYC_18555785_ChIP-Seq_MESCs_Mouse1.99028364
13PPARA_22158963_ChIP-Seq_LIVER_Mouse1.96417644
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.92413356
15STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88894278
16RXR_22158963_ChIP-Seq_LIVER_Mouse1.88611878
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.87070317
18PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.85708095
19STAT3_1855785_ChIP-Seq_MESCs_Mouse1.85001545
20IRF8_22096565_ChIP-ChIP_GC-B_Human1.84266803
21IRF8_21731497_ChIP-ChIP_J774_Mouse1.81699023
22BRD4_25478319_ChIP-Seq_HGPS_Human1.75449955
23HIF1A_21447827_ChIP-Seq_MCF-7_Human1.72125898
24* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.71820899
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.69207768
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.66642267
27* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.66639768
28* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63692823
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.60138030
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.58757302
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56136010
32ATF3_27146783_Chip-Seq_COLON_Human1.55637026
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55338700
34* ELK3_25401928_ChIP-Seq_HUVEC_Human1.53747316
35AR_21909140_ChIP-Seq_LNCAP_Human1.53616097
36* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.53436380
37ESR1_15608294_ChIP-ChIP_MCF-7_Human1.50776112
38UBF1/2_26484160_Chip-Seq_HMECs_Human1.50275733
39* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49322298
40LXR_22158963_ChIP-Seq_LIVER_Mouse1.47940622
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.47290182
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.46741087
43* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46470549
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.45817917
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45477846
46TCF3_18692474_ChIP-Seq_MEFs_Mouse1.44589065
47* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44557161
48* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.44172598
49* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43740839
50VDR_21846776_ChIP-Seq_THP-1_Human1.43426290
51SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40999680
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40724333
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.40053235
54* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39693180
55* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.39202324
56ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37574301
57DCP1A_22483619_ChIP-Seq_HELA_Human1.37526045
58* TFEB_21752829_ChIP-Seq_HELA_Human1.37150004
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36476642
60TCF7_22412390_ChIP-Seq_EML_Mouse1.35866310
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.31789119
62ZNF263_19887448_ChIP-Seq_K562_Human1.30289195
63* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28820743
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.27895002
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27564307
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.27158704
67KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25882159
68KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25882159
69KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25882159
70IRF8_27001747_Chip-Seq_BMDM_Mouse1.24174212
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.23855475
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22917766
73CJUN_26792858_Chip-Seq_BT549_Human1.22366452
74KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21798446
75JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21422036
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21393520
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20490965
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.19087308
79* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18491493
80GATA6_25053715_ChIP-Seq_YYC3_Human1.18352946
81MYC_18358816_ChIP-ChIP_MESCs_Mouse1.17223478
82SOX17_20123909_ChIP-Seq_XEN_Mouse1.16552458
83* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16186823
84* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16186823
85* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16052020
86MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15533273
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15337020
88CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14499366
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14211205
90* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14102801
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13712448
92E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13547274
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13399550
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12807642
95E2F1_21310950_ChIP-Seq_MCF-7_Human1.12639293
96TP53_22127205_ChIP-Seq_IMR90_Human1.11579316
97* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11305777
98* MAF_26560356_Chip-Seq_TH1_Human1.11300825
99* RACK7_27058665_Chip-Seq_MCF-7_Human1.10575793
100SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10529951
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10111866
102NCOR1_26117541_ChIP-Seq_K562_Human1.08836785
103IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08793954
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08543706
105* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07839019
106* CHD1_26751641_Chip-Seq_LNCaP_Human1.07648138
107* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07276959
108* KDM2B_26808549_Chip-Seq_DND41_Human1.04683225
109* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04323383
110* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03905811
111NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03404624
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02931162
113* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02617172
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02241292
115* UTX_26944678_Chip-Seq_JUKART_Human1.02098243
116POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01371259
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01046576
118* RUNX1_22412390_ChIP-Seq_EML_Mouse1.00903495
119GATA4_21415370_ChIP-Seq_HL-1_Mouse1.00771918
120NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00342824
121SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99450099
122* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98371842
123CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98095251
124* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97960874
125FOXO3_23340844_ChIP-Seq_DLD1_Human0.97934424
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97584169
127NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96508484
128SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95827802
129DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95787048
130PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95555255
131VDR_24763502_ChIP-Seq_THP-1_Human0.95500426
132* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95208630
133SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94994704
134HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94970607
135FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93632758
136SOX2_20726797_ChIP-Seq_SW620_Human0.92933592
137SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92388899
138OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92030992

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.88862851
2MP0010352_gastrointestinal_tract_polyps3.84849291
3MP0003950_abnormal_plasma_membrane3.24657531
4MP0004272_abnormal_basement_membrane2.76844706
5MP0005076_abnormal_cell_differentiation2.49269224
6MP0004233_abnormal_muscle_weight2.39248316
7MP0003303_peritoneal_inflammation2.36799496
8MP0003566_abnormal_cell_adhesion2.23428861
9MP0003806_abnormal_nucleotide_metabolis2.16527408
10MP0005451_abnormal_body_composition2.16208962
11MP0005360_urolithiasis2.12961358
12MP0002139_abnormal_hepatobiliary_system2.07456259
13MP0003300_gastrointestinal_ulcer2.05361078
14MP0010307_abnormal_tumor_latency2.05116971
15MP0003436_decreased_susceptibility_to2.04838647
16MP0009840_abnormal_foam_cell2.00045794
17MP0003941_abnormal_skin_development1.96289235
18MP0010234_abnormal_vibrissa_follicle1.90492702
19MP0009278_abnormal_bone_marrow1.88960023
20MP0002877_abnormal_melanocyte_morpholog1.87005878
21MP0005023_abnormal_wound_healing1.74714703
22MP0004947_skin_inflammation1.64592240
23MP0008438_abnormal_cutaneous_collagen1.57928449
24MP0001348_abnormal_lacrimal_gland1.52559059
25MP0009785_altered_susceptibility_to1.52427493
26MP0009053_abnormal_anal_canal1.50133849
27MP0001849_ear_inflammation1.49580461
28MP0000858_altered_metastatic_potential1.49414915
29MP0003453_abnormal_keratinocyte_physiol1.47279616
30MP0003448_altered_tumor_morphology1.42193996
31MP0003091_abnormal_cell_migration1.38973627
32MP0003252_abnormal_bile_duct1.34118853
33MP0004957_abnormal_blastocyst_morpholog1.32065608
34MP0003279_aneurysm1.28686149
35MP0000490_abnormal_crypts_of1.27647508
36MP0002896_abnormal_bone_mineralization1.27599877
37MP0005197_abnormal_uvea_morphology1.25663257
38MP0004197_abnormal_fetal_growth/weight/1.24931809
39MP0006082_CNS_inflammation1.24624387
40MP0000733_abnormal_muscle_development1.22847484
41MP0003693_abnormal_embryo_hatching1.22661245
42MP0005058_abnormal_lysosome_morphology1.22179544
43MP0009697_abnormal_copulation1.21942745
44MP0005257_abnormal_intraocular_pressure1.20964216
45MP0001958_emphysema1.18378448
46MP0005085_abnormal_gallbladder_physiolo1.16317542
47MP0005397_hematopoietic_system_phenotyp1.15286628
48MP0001545_abnormal_hematopoietic_system1.15286628
49* MP0001730_embryonic_growth_arrest1.13544153
50MP0008260_abnormal_autophagy1.13224737
51* MP0000350_abnormal_cell_proliferation1.12370633
52MP0010155_abnormal_intestine_physiology1.11992926
53MP0005083_abnormal_biliary_tract1.11775736
54MP0005621_abnormal_cell_physiology1.11631724
55MP0003656_abnormal_erythrocyte_physiolo1.11287025
56MP0002419_abnormal_innate_immunity1.10669859
57MP0003186_abnormal_redox_activity1.10042478
58MP0010030_abnormal_orbit_morphology1.09435397
59MP0005164_abnormal_response_to1.09370372
60* MP0002086_abnormal_extraembryonic_tissu1.08923818
61MP0005025_abnormal_response_to1.07466527
62MP0010368_abnormal_lymphatic_system1.06773706
63MP0005464_abnormal_platelet_physiology1.06005814
64MP0003077_abnormal_cell_cycle1.05852636
65MP0008932_abnormal_embryonic_tissue1.05002668
66MP0003191_abnormal_cellular_cholesterol1.04856994
67MP0000685_abnormal_immune_system1.04822975
68MP0000609_abnormal_liver_physiology1.04104440
69MP0000569_abnormal_digit_pigmentation1.03296297
70MP0005365_abnormal_bile_salt1.03020633
71MP0004858_abnormal_nervous_system1.02556102
72MP0001915_intracranial_hemorrhage1.01690084
73MP0005000_abnormal_immune_tolerance1.01232758
74MP0002088_abnormal_embryonic_growth/wei1.01108772
75MP0003828_pulmonary_edema1.00812222
76MP0003111_abnormal_nucleus_morphology1.00754031
77MP0001533_abnormal_skeleton_physiology1.00749859
78MP0003984_embryonic_growth_retardation1.00376749
79MP0000767_abnormal_smooth_muscle1.00090900
80MP0005165_increased_susceptibility_to0.99734681
81* MP0001672_abnormal_embryogenesis/_devel0.98247516
82* MP0005380_embryogenesis_phenotype0.98247516
83MP0010094_abnormal_chromosome_stability0.97878548
84MP0000598_abnormal_liver_morphology0.96801606
85MP0005501_abnormal_skin_physiology0.95579263
86MP0001835_abnormal_antigen_presentation0.94942391
87MP0004808_abnormal_hematopoietic_stem0.94518708
88MP0003221_abnormal_cardiomyocyte_apopto0.94244770
89MP0002405_respiratory_system_inflammati0.93757882
90MP0000627_abnormal_mammary_gland0.92241809
91MP0001845_abnormal_inflammatory_respons0.91711786
92MP0002452_abnormal_antigen_presenting0.91383642
93MP0000013_abnormal_adipose_tissue0.90712694
94MP0005275_abnormal_skin_tensile0.90693448
95MP0006054_spinal_hemorrhage0.90232456
96MP0001243_abnormal_dermal_layer0.90019623
97MP0009333_abnormal_splenocyte_physiolog0.89868201
98MP0000747_muscle_weakness0.89648945
99MP0008007_abnormal_cellular_replicative0.88238095
100MP0002254_reproductive_system_inflammat0.87260883
101MP0000003_abnormal_adipose_tissue0.86188731
102MP0000477_abnormal_intestine_morphology0.85778532
103MP0001216_abnormal_epidermal_layer0.85516221
104MP0003172_abnormal_lysosome_physiology0.85496011
105MP0002138_abnormal_hepatobiliary_system0.85018160
106MP0000762_abnormal_tongue_morphology0.84498830
107MP0000537_abnormal_urethra_morphology0.84074116
108* MP0001697_abnormal_embryo_size0.83764778
109MP0001661_extended_life_span0.83750601
110MP0000371_diluted_coat_color0.83719939
111MP0005319_abnormal_enzyme/_coenzyme0.83672870
112MP0005193_abnormal_anterior_eye0.83123901
113* MP0002084_abnormal_developmental_patter0.82633092
114MP0004264_abnormal_extraembryonic_tissu0.82615982
115MP0005384_cellular_phenotype0.82314932
116MP0000358_abnormal_cell_content/0.82079599
117MP0002796_impaired_skin_barrier0.81427498
118MP0002269_muscular_atrophy0.80679927
119MP0003890_abnormal_embryonic-extraembry0.80351614
120MP0002998_abnormal_bone_remodeling0.80329232
121MP0008469_abnormal_protein_level0.80237247
122MP0002060_abnormal_skin_morphology0.80205488
123* MP0002080_prenatal_lethality0.79633264
124MP0002019_abnormal_tumor_incidence0.79505930
125MP0000428_abnormal_craniofacial_morphol0.78532435
126MP0005623_abnormal_meninges_morphology0.78354553
127MP0000343_altered_response_to0.78148267
128MP0009780_abnormal_chondrocyte_physiolo0.76921994
129MP0001542_abnormal_bone_strength0.76920350
130MP0009763_increased_sensitivity_to0.76910940
131MP0001853_heart_inflammation0.76308544
132MP0001666_abnormal_nutrient_absorption0.75498645
133MP0000751_myopathy0.74900931
134MP0002723_abnormal_immune_serum0.74783777
135MP0010329_abnormal_lipoprotein_level0.74673116
136MP0002332_abnormal_exercise_endurance0.74496412
137MP0001299_abnormal_eye_distance/0.73253197
138MP0000759_abnormal_skeletal_muscle0.73161179
139MP0009764_decreased_sensitivity_to0.73007234
140MP0002148_abnormal_hypersensitivity_rea0.72781387
141MP0000749_muscle_degeneration0.72754266
142MP0010678_abnormal_skin_adnexa0.72608137
143MP0004185_abnormal_adipocyte_glucose0.72469208
144MP0005167_abnormal_blood-brain_barrier0.72350060
145MP0001800_abnormal_humoral_immune0.71835091
146* MP0002085_abnormal_embryonic_tissue0.71205251
147MP0005408_hypopigmentation0.69455491
148MP0003868_abnormal_feces_composition0.68363610
149MP0002295_abnormal_pulmonary_circulatio0.68249720

Predicted human phenotypes

RankGene SetZ-score
1Short nail (HP:0001799)3.84536343
2Arterial tortuosity (HP:0005116)3.39104276
3Vascular tortuosity (HP:0004948)3.32387950
4Eczematoid dermatitis (HP:0000976)3.13217451
5Recurrent gram-negative bacterial infections (HP:0005420)2.94740858
6Spastic diplegia (HP:0001264)2.93865395
7Abnormality of liposaccharide metabolism (HP:0010968)2.85201040
8Abnormality of glycosphingolipid metabolism (HP:0004343)2.85201040
9Abnormality of glycolipid metabolism (HP:0010969)2.85201040
10Hyperacusis (HP:0010780)2.81367451
11Broad face (HP:0000283)2.80791566
12Myocardial infarction (HP:0001658)2.77904338
13Peritonitis (HP:0002586)2.77837825
14Abnormality of monocarboxylic acid metabolism (HP:0010996)2.77784838
15Protrusio acetabuli (HP:0003179)2.76042616
16Distal lower limb amyotrophy (HP:0008944)2.74005112
17Wormian bones (HP:0002645)2.69624525
18Aortic dissection (HP:0002647)2.67364715
19Ulnar bowing (HP:0003031)2.63891921
20Spinal rigidity (HP:0003306)2.61111517
21Abnormality of glutamine family amino acid metabolism (HP:0010902)2.59487544
22Increased density of long bones (HP:0006392)2.51210120
23Tetraparesis (HP:0002273)2.50532268
24Aortic aneurysm (HP:0004942)2.49362484
25Subacute progressive viral hepatitis (HP:0006572)2.46028551
26Esophageal varix (HP:0002040)2.45750860
27Abnormality of proline metabolism (HP:0010907)2.44576167
28Hydroxyprolinuria (HP:0003080)2.44576167
29Increased mean platelet volume (HP:0011877)2.43887516
30Insidious onset (HP:0003587)2.43464907
31Termporal pattern (HP:0011008)2.43464907
32Spondylolisthesis (HP:0003302)2.43242573
33Elbow flexion contracture (HP:0002987)2.42241461
34Mitral stenosis (HP:0001718)2.42036589
35Cerebral aneurysm (HP:0004944)2.39598826
36Entropion (HP:0000621)2.33770773
37Interstitial pulmonary disease (HP:0006530)2.33770061
38Atrophic scars (HP:0001075)2.29650406
39Abnormality of oral frenula (HP:0000190)2.29522746
40Syringomyelia (HP:0003396)2.28290223
41Spinal cord lesions (HP:0100561)2.28290223
42Autoimmune thrombocytopenia (HP:0001973)2.27656891
43Deep venous thrombosis (HP:0002625)2.25921654
44Absent frontal sinuses (HP:0002688)2.25102372
45Distal upper limb amyotrophy (HP:0007149)2.22083308
46Upper limb amyotrophy (HP:0009129)2.22083308
47Vertebral compression fractures (HP:0002953)2.20409454
48Abnormal platelet volume (HP:0011876)2.19349553
49Xanthomatosis (HP:0000991)2.17680105
50Distal lower limb muscle weakness (HP:0009053)2.17675297
51Hand muscle atrophy (HP:0009130)2.17250322
52Upper limb muscle weakness (HP:0003484)2.16193480
53Natal tooth (HP:0000695)2.14902057
54Fragile skin (HP:0001030)2.14778066
55Reduced subcutaneous adipose tissue (HP:0003758)2.14341796
56Mitral regurgitation (HP:0001653)2.14042585
57Recurrent abscess formation (HP:0002722)2.13936767
58Premature rupture of membranes (HP:0001788)2.13303500
59Metaphyseal cupping (HP:0003021)2.11874450
60Radial bowing (HP:0002986)2.11739567
61Cervical subluxation (HP:0003308)2.10281944
62Nuclear cataract (HP:0100018)2.10014727
63Abnormality of the umbilical cord (HP:0010881)2.08856454
64Cardiovascular calcification (HP:0011915)2.08032368
65Intrahepatic cholestasis (HP:0001406)2.06461709
66Recurrent bacterial skin infections (HP:0005406)2.04986407
67Asymmetry of the thorax (HP:0001555)2.04364826
68Cerebral inclusion bodies (HP:0100314)2.03970735
69Bladder diverticulum (HP:0000015)2.03016694
70Conjugated hyperbilirubinemia (HP:0002908)2.02996938
71Abnormality of the acetabulum (HP:0003170)2.01988439
72Lower limb amyotrophy (HP:0007210)2.01775339
73Hematochezia (HP:0002573)2.00771310
74Shallow orbits (HP:0000586)2.00602948
75Increased connective tissue (HP:0009025)1.98256141
76Fused cervical vertebrae (HP:0002949)1.98248706
77Osteolytic defects of the hand bones (HP:0009699)1.97577316
78Osteolytic defects of the phalanges of the hand (HP:0009771)1.97577316
79Hypobetalipoproteinemia (HP:0003563)1.97376205
80Cortical dysplasia (HP:0002539)1.97372164
81Upper motor neuron abnormality (HP:0002127)1.97247311
82Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.97090175
83Gastrointestinal carcinoma (HP:0002672)1.96190287
84Malignant gastrointestinal tract tumors (HP:0006749)1.96190287
85Multiple enchondromatosis (HP:0005701)1.96007223
86Spinal cord compression (HP:0002176)1.94471150
87Back pain (HP:0003418)1.94283262
88Ankyloglossia (HP:0010296)1.94163693
89Rectal prolapse (HP:0002035)1.93768933
90Persistence of primary teeth (HP:0006335)1.93687975
91Abnormality of pyrimidine metabolism (HP:0004353)1.93443242
92Micronodular cirrhosis (HP:0001413)1.92614098
93Increased cerebral lipofuscin (HP:0011813)1.92259596
94Blue sclerae (HP:0000592)1.90746134
95Abnormality of macrophages (HP:0004311)1.90556683
96Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.90485578
97Insomnia (HP:0100785)1.89770159
98Increased serum ferritin (HP:0003281)1.89486525
99Dilatation of the ascending aorta (HP:0005111)1.89175688
100Abnormality of dentin (HP:0010299)1.88556325
101Genu recurvatum (HP:0002816)1.88432645
102Limb-girdle muscle atrophy (HP:0003797)1.88025348
103Pseudobulbar signs (HP:0002200)1.87471223
104Abnormality of iron homeostasis (HP:0011031)1.86933756
105Abnormal ossification of hand bones (HP:0005921)1.85898651
106Mediastinal lymphadenopathy (HP:0100721)1.85221581
107Abnormality of the peritoneum (HP:0002585)1.84735069
108Bowed forearm bones (HP:0003956)1.84139146
109Bowing of the arm (HP:0006488)1.84139146
110Abnormality of the distal phalanges of the toes (HP:0010182)1.83722251
111Abnormality of carpal bone ossification (HP:0006257)1.83167673
112Thin bony cortex (HP:0002753)1.82791837
113Abnormality of the common coagulation pathway (HP:0010990)1.81387534
114Aneurysm (HP:0002617)1.81289583
115Orchitis (HP:0100796)1.81100802
116Aortic regurgitation (HP:0001659)1.80890676
117Mitral valve prolapse (HP:0001634)1.80424234
118Long toe (HP:0010511)1.79912177
119Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.78923402
120Turricephaly (HP:0000262)1.78405182
121Elevated erythrocyte sedimentation rate (HP:0003565)1.78279378
122Rough bone trabeculation (HP:0100670)1.77168542
123Relative macrocephaly (HP:0004482)1.77165241
124Abnormal cartilage morphology (HP:0002763)1.76516627
125Ependymoma (HP:0002888)1.76458955
126Abnormality of the Achilles tendon (HP:0005109)1.74415031
127Selective tooth agenesis (HP:0001592)1.74316436
128Hepatocellular carcinoma (HP:0001402)1.74314229
129Shoulder girdle muscle weakness (HP:0003547)1.73017724
130Periodontitis (HP:0000704)1.72628653
131Ankle contracture (HP:0006466)1.72145443
132Pelvic girdle muscle weakness (HP:0003749)1.71001708
133Bone pain (HP:0002653)1.70445695
134Trismus (HP:0000211)1.70199734
135Missing ribs (HP:0000921)1.70003132
136Abnormality of transition element cation homeostasis (HP:0011030)1.69899420
137Long palpebral fissure (HP:0000637)1.68515392
138Delayed cranial suture closure (HP:0000270)1.68433917
139Myositis (HP:0100614)1.68203198
140Cutaneous melanoma (HP:0012056)1.68169391
141Vascular calcification (HP:0004934)1.67635886
142Tibial bowing (HP:0002982)1.67087454
143Biliary tract neoplasm (HP:0100574)1.66831874
144Abnormality of the fetal cardiovascular system (HP:0010948)1.66444681
145Abnormal umbilical cord blood vessels (HP:0011403)1.66444681
146Single umbilical artery (HP:0001195)1.66444681
147Deviation of the thumb (HP:0009603)1.66300278
148Abnormality of the calcaneus (HP:0008364)1.66003461
149Difficulty climbing stairs (HP:0003551)1.65775447
150Agnosia (HP:0010524)1.65766914
151Uterine neoplasm (HP:0010784)1.65536055
152Elfin facies (HP:0004428)1.65425209
153Neurofibrillary tangles (HP:0002185)1.65097812
154Generalized amyotrophy (HP:0003700)1.64927639
155Orthostatic hypotension (HP:0001278)1.64831073
156Flat acetabular roof (HP:0003180)1.64558208
157Achilles tendon contracture (HP:0001771)1.64486726
158Hypolipoproteinemia (HP:0010981)1.62325507
159Arterial thrombosis (HP:0004420)1.61580107
160Gingivitis (HP:0000230)1.61466881
161Abnormality of sulfur amino acid metabolism (HP:0004339)1.60614828
162Disinhibition (HP:0000734)1.58633898
163Bilateral sensorineural hearing impairment (HP:0008619)1.57913282
164Abnormality of complement system (HP:0005339)1.56282822
165Hypercholesterolemia (HP:0003124)1.53500991
166Cellulitis (HP:0100658)1.53338571
167Leiomyosarcoma (HP:0100243)1.52607465
168Uterine leiomyosarcoma (HP:0002891)1.52607465
169Pustule (HP:0200039)1.52470304

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.30750325
2PKN22.95065695
3EPHA22.64353084
4ERN12.63279637
5CDK122.60617983
6MAP3K102.55140667
7TTN2.29427894
8EEF2K2.24163084
9SCYL22.11841436
10TBK11.99702971
11RIPK11.96386380
12BMX1.95191270
13PTK61.90903357
14STK101.80584043
15EIF2AK11.72134572
16RPS6KA41.70000614
17PBK1.62472530
18LIMK11.61891304
19LATS11.58950118
20SMG11.57906317
21LRRK21.54770375
22TSSK61.54641104
23PDGFRA1.53009466
24CDK61.50375686
25MAP3K141.49722680
26PAK41.43485097
27FLT31.39609176
28MAP3K121.36455650
29BUB11.34959471
30MYLK1.33333757
31TESK11.32625252
32MAP3K81.32546006
33MST1R1.31482550
34NTRK11.31095213
35FGFR41.30194576
36NEK21.28467351
37CDC71.27446596
38EIF2AK31.27052474
39ALK1.25219633
40DDR21.24475475
41RPS6KB21.24338430
42SIK11.24137790
43CDK81.23781496
44MOS1.19243409
45CHUK1.16150236
46NME21.13252333
47NEK11.12665892
48STK31.12525941
49MAP2K31.11699591
50MET1.11420959
51PTK21.09983386
52JAK31.08784360
53PIM21.07936704
54MAP3K31.06902648
55MTOR1.06887617
56TESK21.04073589
57CDK41.02297596
58PIM11.01726302
59TGFBR11.00826247
60BRSK21.00286448
61PDK21.00278470
62MAP3K110.98790395
63PASK0.98160216
64TGFBR20.97377308
65TYK20.95078541
66PAK20.92562970
67IKBKB0.90188279
68PRPF4B0.88887939
69IRAK30.86702103
70MST40.84665114
71NEK90.83516979
72CSK0.81909241
73LMTK20.81346122
74EPHB10.78976209
75ARAF0.77071643
76TTK0.76002476
77STK40.75464534
78LATS20.74919277
79KSR10.74166685
80ZAP700.71929256
81ABL20.71811075
82MAP3K50.67417807
83ERBB30.67223757
84PDGFRB0.66939059
85FGFR10.66535365
86FGFR30.66256050
87ICK0.65887096
88DYRK1B0.65744154
89MAP4K10.65481738
90CDK70.65126354
91STK380.64141739
92BRSK10.62560469
93BMPR20.61827394
94MATK0.61708288
95MAP3K90.61567961
96JAK10.60657347
97ILK0.59528171
98WEE10.59301017
99EGFR0.59202454
100AURKB0.58385062
101SRPK10.57909686
102EPHA30.57476414
103JAK20.57005910
104BLK0.56986100
105GRK70.54934599
106ACVR1B0.54465237
107TAOK30.53524470
108SIK30.53088059
109MAP2K20.52990440
110PRKG20.52468143
111CSF1R0.51507378
112TRPM70.50202541
113RIPK40.49774218
114CLK10.49391581
115CDK90.48833363
116GSK3A0.48776522
117BRAF0.48760502
118MAPKAPK30.47561482
119KSR20.47471068
120IKBKE0.46589243
121TAOK10.46366026
122MARK30.45944944
123RPS6KA10.44784780
124ROCK20.44742904
125HCK0.43589171
126MELK0.43003525
127AKT20.42954674
128TAOK20.42436938
129ATR0.42301038
130FER0.41828111
131MAPKAPK20.41773372
132FGR0.41674512
133MAP3K130.41631912
134MAP3K20.41040518
135AURKA0.40469297
136AKT30.39946317
137CHEK20.39564841
138CAMK2G0.35735528
139PLK10.35225846
140CHEK10.34830028
141IRAK20.34721714
142DMPK0.34007840
143PAK10.30283066

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006702.36452545
2Legionellosis_Homo sapiens_hsa051342.26358057
3Leishmaniasis_Homo sapiens_hsa051402.04788246
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.02930251
5Other glycan degradation_Homo sapiens_hsa005111.75731169
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.67983550
7Staphylococcus aureus infection_Homo sapiens_hsa051501.67223810
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.66439606
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.66000504
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.65702897
11ECM-receptor interaction_Homo sapiens_hsa045121.64451084
12Vitamin B6 metabolism_Homo sapiens_hsa007501.63998911
13Nitrogen metabolism_Homo sapiens_hsa009101.62913258
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61451397
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.50988396
16TNF signaling pathway_Homo sapiens_hsa046681.50643824
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.48670851
18Fructose and mannose metabolism_Homo sapiens_hsa000511.45644975
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40593618
20Chronic myeloid leukemia_Homo sapiens_hsa052201.39537536
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.38620412
22Arginine biosynthesis_Homo sapiens_hsa002201.37779220
23Bladder cancer_Homo sapiens_hsa052191.33613033
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.33360671
25Small cell lung cancer_Homo sapiens_hsa052221.32475281
26Apoptosis_Homo sapiens_hsa042101.31714076
27Graft-versus-host disease_Homo sapiens_hsa053321.30477124
28Malaria_Homo sapiens_hsa051441.29198814
29p53 signaling pathway_Homo sapiens_hsa041151.26988361
30Pertussis_Homo sapiens_hsa051331.25978027
31Shigellosis_Homo sapiens_hsa051311.24593138
32Osteoclast differentiation_Homo sapiens_hsa043801.22255214
33MicroRNAs in cancer_Homo sapiens_hsa052061.21628723
34Complement and coagulation cascades_Homo sapiens_hsa046101.20918046
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19128755
36Renal cell carcinoma_Homo sapiens_hsa052111.17389201
37N-Glycan biosynthesis_Homo sapiens_hsa005101.12066515
38Amoebiasis_Homo sapiens_hsa051461.11831086
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.11727189
40Vibrio cholerae infection_Homo sapiens_hsa051101.10926787
41Adherens junction_Homo sapiens_hsa045201.09213617
42Salmonella infection_Homo sapiens_hsa051321.09085424
43Proteoglycans in cancer_Homo sapiens_hsa052051.08953193
44Toxoplasmosis_Homo sapiens_hsa051451.08106919
45Viral carcinogenesis_Homo sapiens_hsa052031.07855354
46Regulation of actin cytoskeleton_Homo sapiens_hsa048101.07054966
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06584314
48Tuberculosis_Homo sapiens_hsa051521.06043918
49Measles_Homo sapiens_hsa051621.04309128
50Influenza A_Homo sapiens_hsa051641.02838149
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02250224
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01863076
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00647062
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99724793
55Sulfur metabolism_Homo sapiens_hsa009200.99465189
56Viral myocarditis_Homo sapiens_hsa054160.97623951
57Herpes simplex infection_Homo sapiens_hsa051680.95946110
58Antigen processing and presentation_Homo sapiens_hsa046120.95319880
59Caffeine metabolism_Homo sapiens_hsa002320.95044766
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.92461707
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.92272330
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.91880577
63Type I diabetes mellitus_Homo sapiens_hsa049400.90725738
64Prostate cancer_Homo sapiens_hsa052150.90220353
65Biosynthesis of amino acids_Homo sapiens_hsa012300.89737617
66RNA transport_Homo sapiens_hsa030130.89285515
67Hippo signaling pathway_Homo sapiens_hsa043900.88940670
68DNA replication_Homo sapiens_hsa030300.88687031
69Hepatitis B_Homo sapiens_hsa051610.87803751
70Acute myeloid leukemia_Homo sapiens_hsa052210.87437260
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87358078
72mTOR signaling pathway_Homo sapiens_hsa041500.87238276
73Nucleotide excision repair_Homo sapiens_hsa034200.85171300
74* Selenocompound metabolism_Homo sapiens_hsa004500.84044822
75Melanoma_Homo sapiens_hsa052180.81630961
76Steroid biosynthesis_Homo sapiens_hsa001000.81474978
77Tryptophan metabolism_Homo sapiens_hsa003800.80945783
78Non-small cell lung cancer_Homo sapiens_hsa052230.80515365
79Sphingolipid metabolism_Homo sapiens_hsa006000.80012122
80Non-homologous end-joining_Homo sapiens_hsa034500.79286298
81Fat digestion and absorption_Homo sapiens_hsa049750.79143203
82Insulin resistance_Homo sapiens_hsa049310.78891268
83Prion diseases_Homo sapiens_hsa050200.77964351
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76488468
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75745112
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75275007
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.74827311
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74789482
89Focal adhesion_Homo sapiens_hsa045100.73313210
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72999701
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.72587867
92Pentose phosphate pathway_Homo sapiens_hsa000300.72169048
93Lysine degradation_Homo sapiens_hsa003100.71783165
94Glioma_Homo sapiens_hsa052140.71233871
95Endometrial cancer_Homo sapiens_hsa052130.71154482
96Pancreatic cancer_Homo sapiens_hsa052120.69994228
97Pyruvate metabolism_Homo sapiens_hsa006200.68484974
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68179085
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67904080
100Hepatitis C_Homo sapiens_hsa051600.67520881
101HTLV-I infection_Homo sapiens_hsa051660.66251085
102Lysosome_Homo sapiens_hsa041420.66004684
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65999602
104Starch and sucrose metabolism_Homo sapiens_hsa005000.65600586
105Phagosome_Homo sapiens_hsa041450.65578327
106Pathways in cancer_Homo sapiens_hsa052000.65291935
107Carbon metabolism_Homo sapiens_hsa012000.65198567
108Endocytosis_Homo sapiens_hsa041440.65089156
109Folate biosynthesis_Homo sapiens_hsa007900.64623379
110Tight junction_Homo sapiens_hsa045300.64384702
111Thyroid cancer_Homo sapiens_hsa052160.64195190
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.63924034
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63770235
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63751556
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63644640
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.63265675
117Cell cycle_Homo sapiens_hsa041100.63230739
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62720665
119Systemic lupus erythematosus_Homo sapiens_hsa053220.62200120
120HIF-1 signaling pathway_Homo sapiens_hsa040660.61848619
121Epstein-Barr virus infection_Homo sapiens_hsa051690.59894663
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59847565
123Galactose metabolism_Homo sapiens_hsa000520.59707075
124Proteasome_Homo sapiens_hsa030500.58798171
125Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58763636
126Allograft rejection_Homo sapiens_hsa053300.58714352
127TGF-beta signaling pathway_Homo sapiens_hsa043500.58147015
128Hematopoietic cell lineage_Homo sapiens_hsa046400.57738749
129PPAR signaling pathway_Homo sapiens_hsa033200.57609923
130ErbB signaling pathway_Homo sapiens_hsa040120.57338674
131Glutathione metabolism_Homo sapiens_hsa004800.55863727
132B cell receptor signaling pathway_Homo sapiens_hsa046620.55787462
133Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55099419
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54581504
135Fatty acid degradation_Homo sapiens_hsa000710.54190745
136Prolactin signaling pathway_Homo sapiens_hsa049170.54112282
137Dilated cardiomyopathy_Homo sapiens_hsa054140.50905673
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49517432
139Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48857068
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.47501933
141Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47102239
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45668022
143Insulin signaling pathway_Homo sapiens_hsa049100.44123356
144VEGF signaling pathway_Homo sapiens_hsa043700.43260561

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