TXNRD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)5.75167716
2L-phenylalanine catabolic process (GO:0006559)5.45917075
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.45917075
4protoporphyrinogen IX biosynthetic process (GO:0006782)5.44998558
5L-phenylalanine metabolic process (GO:0006558)5.39449451
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.39449451
7lysine catabolic process (GO:0006554)5.15428260
8lysine metabolic process (GO:0006553)5.15428260
9cysteine metabolic process (GO:0006534)5.02117268
10aromatic amino acid family catabolic process (GO:0009074)4.96727007
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.89400958
12positive regulation of histone deacetylation (GO:0031065)4.81449922
13indole-containing compound catabolic process (GO:0042436)4.55085582
14indolalkylamine catabolic process (GO:0046218)4.55085582
15tryptophan catabolic process (GO:0006569)4.55085582
16glyoxylate metabolic process (GO:0046487)4.54700102
17heme biosynthetic process (GO:0006783)4.52691568
18kynurenine metabolic process (GO:0070189)4.49363198
19sulfur amino acid catabolic process (GO:0000098)4.49143988
20alpha-linolenic acid metabolic process (GO:0036109)4.48718501
21positive regulation of triglyceride biosynthetic process (GO:0010867)4.45774081
22base-excision repair, AP site formation (GO:0006285)4.42916761
23ethanol oxidation (GO:0006069)4.39855092
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.29322572
25tryptophan metabolic process (GO:0006568)4.26845076
26porphyrin-containing compound biosynthetic process (GO:0006779)4.17121423
27heme metabolic process (GO:0042168)4.11853732
28glycine metabolic process (GO:0006544)4.08854696
29high-density lipoprotein particle remodeling (GO:0034375)4.08333980
30pseudouridine synthesis (GO:0001522)4.05154025
31bile acid biosynthetic process (GO:0006699)4.04805012
32peptidyl-histidine modification (GO:0018202)4.04252025
33cellular ketone body metabolic process (GO:0046950)4.03753390
34amino-acid betaine metabolic process (GO:0006577)3.96333447
35L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.96288575
36serine family amino acid catabolic process (GO:0009071)3.94769633
37S-adenosylmethionine metabolic process (GO:0046500)3.93082128
38L-methionine salvage (GO:0071267)3.92657878
39L-methionine biosynthetic process (GO:0071265)3.92657878
40amino acid salvage (GO:0043102)3.92657878
41regulation of triglyceride catabolic process (GO:0010896)3.92358716
42negative regulation of fibrinolysis (GO:0051918)3.86919928
43tetrapyrrole biosynthetic process (GO:0033014)3.85623204
44serine family amino acid metabolic process (GO:0009069)3.83459636
45porphyrin-containing compound metabolic process (GO:0006778)3.83207397
46DNA deamination (GO:0045006)3.79298191
47urea cycle (GO:0000050)3.75810985
48urea metabolic process (GO:0019627)3.75810985
49serine family amino acid biosynthetic process (GO:0009070)3.74184908
50regulation of protein activation cascade (GO:2000257)3.73240130
51aromatic amino acid family metabolic process (GO:0009072)3.72641871
52valine metabolic process (GO:0006573)3.71694499
53protein carboxylation (GO:0018214)3.69879466
54peptidyl-glutamic acid carboxylation (GO:0017187)3.69879466
55GDP-mannose metabolic process (GO:0019673)3.69335862
56regulation of triglyceride biosynthetic process (GO:0010866)3.68599869
57alpha-amino acid catabolic process (GO:1901606)3.67919889
58response to misfolded protein (GO:0051788)3.66584084
59regulation of fibrinolysis (GO:0051917)3.62634718
60protein-lipid complex remodeling (GO:0034368)3.61655767
61macromolecular complex remodeling (GO:0034367)3.61655767
62plasma lipoprotein particle remodeling (GO:0034369)3.61655767
63methionine biosynthetic process (GO:0009086)3.60837337
64homocysteine metabolic process (GO:0050667)3.58794433
65reverse cholesterol transport (GO:0043691)3.58601537
66aspartate family amino acid catabolic process (GO:0009068)3.58418864
672-oxoglutarate metabolic process (GO:0006103)3.57649845
68fatty acid beta-oxidation (GO:0006635)3.56100118
69pyrimidine-containing compound salvage (GO:0008655)3.55384666
70pyrimidine nucleoside salvage (GO:0043097)3.55384666
71positive regulation of protein deacetylation (GO:0090312)3.53680942
72short-chain fatty acid metabolic process (GO:0046459)3.53262614
73bile acid metabolic process (GO:0008206)3.51880488
74regulation of hippo signaling (GO:0035330)3.51023403
75fatty acid oxidation (GO:0019395)3.50434670
76heme transport (GO:0015886)3.49205432
77nitrogen cycle metabolic process (GO:0071941)3.49126756
78plasma lipoprotein particle assembly (GO:0034377)3.48833549
79regulation of complement activation (GO:0030449)3.48576847
80nucleoside salvage (GO:0043174)3.47795960
81ketone body metabolic process (GO:1902224)3.45988607
82complement activation, alternative pathway (GO:0006957)3.45970142
83cellular amino acid catabolic process (GO:0009063)3.45117833
84negative regulation of cholesterol transport (GO:0032375)3.44368281
85negative regulation of sterol transport (GO:0032372)3.44368281
86acylglycerol homeostasis (GO:0055090)3.43091539
87triglyceride homeostasis (GO:0070328)3.43091539
88lipid oxidation (GO:0034440)3.42163753
89tRNA modification (GO:0006400)3.41429433
90regulation of cholesterol esterification (GO:0010872)3.41336591
91aldehyde catabolic process (GO:0046185)3.39126679
92imidazole-containing compound metabolic process (GO:0052803)3.34615502
93bile acid and bile salt transport (GO:0015721)3.33012022
94fatty acid catabolic process (GO:0009062)3.31018841
95cellular response to ATP (GO:0071318)3.30496641
96blood coagulation, intrinsic pathway (GO:0007597)3.30429974
97tyrosine metabolic process (GO:0006570)3.30216989
98carnitine metabolic process (GO:0009437)3.29317717
99plasma lipoprotein particle clearance (GO:0034381)3.27018018
100mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.25925792
101mitochondrial respiratory chain complex I assembly (GO:0032981)3.25925792
102NADH dehydrogenase complex assembly (GO:0010257)3.25925792
103misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.25346748
104phospholipid efflux (GO:0033700)3.25219973
105response to nitrosative stress (GO:0051409)3.24972609
106carboxylic acid catabolic process (GO:0046395)3.24136000
107organic acid catabolic process (GO:0016054)3.24136000
108branched-chain amino acid catabolic process (GO:0009083)3.23852662
109opioid receptor signaling pathway (GO:0038003)3.21566825
110monocarboxylic acid catabolic process (GO:0072329)3.21313285
111sulfur amino acid biosynthetic process (GO:0000097)3.20487620
112very-low-density lipoprotein particle assembly (GO:0034379)3.20315480
113cofactor catabolic process (GO:0051187)3.20185607
114deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.20172693
115acetyl-CoA metabolic process (GO:0006084)3.19771532
116ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.18995225
117behavioral response to nicotine (GO:0035095)3.18657249
118indolalkylamine metabolic process (GO:0006586)3.18045873
119ethanol metabolic process (GO:0006067)3.16686445
120aspartate family amino acid biosynthetic process (GO:0009067)3.15269936
121autophagic vacuole fusion (GO:0000046)3.15052664
122nicotinamide nucleotide biosynthetic process (GO:0019359)3.14844211
123pyridine nucleotide biosynthetic process (GO:0019363)3.14844211
124folic acid metabolic process (GO:0046655)3.14793472
125DNA methylation involved in gamete generation (GO:0043046)3.14370397
126drug catabolic process (GO:0042737)3.14004164
127amine catabolic process (GO:0009310)3.13284772
128cellular biogenic amine catabolic process (GO:0042402)3.13284772
129exogenous drug catabolic process (GO:0042738)3.13192244
130cellular modified amino acid catabolic process (GO:0042219)3.13054813
131NAD biosynthetic process (GO:0009435)3.12910778
132benzene-containing compound metabolic process (GO:0042537)3.12054496
133positive regulation of triglyceride metabolic process (GO:0090208)3.11393304
134mannosylation (GO:0097502)3.08120323
135branched-chain amino acid metabolic process (GO:0009081)3.07775689
136methionine metabolic process (GO:0006555)3.05837191
137cardiolipin metabolic process (GO:0032048)3.00941475
138ncRNA 3-end processing (GO:0043628)3.00216616
139ubiquinone biosynthetic process (GO:0006744)2.90273058
140drug transport (GO:0015893)2.89695763
141regulation of histone deacetylation (GO:0031063)2.86283259
142negative regulation of reactive oxygen species metabolic process (GO:2000378)2.82768206
143regulation of nuclear cell cycle DNA replication (GO:0033262)2.81850943
144piRNA metabolic process (GO:0034587)2.81826325
145tRNA methylation (GO:0030488)2.81565904
146N-acetylneuraminate metabolic process (GO:0006054)2.81176840
147negative regulation of cAMP-mediated signaling (GO:0043951)2.79283586
148negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.78247856
149meiotic chromosome segregation (GO:0045132)2.76498523
150maturation of 5.8S rRNA (GO:0000460)2.75873578
151phosphatidylglycerol biosynthetic process (GO:0006655)2.74117314
152organic cation transport (GO:0015695)2.74053848
153mitochondrial RNA metabolic process (GO:0000959)2.72941130
154negative regulation of telomere maintenance (GO:0032205)2.72859529
155preassembly of GPI anchor in ER membrane (GO:0016254)2.69843002
156protein complex biogenesis (GO:0070271)2.66487855
157regulation of hydrogen peroxide metabolic process (GO:0010310)2.66338347
158water-soluble vitamin biosynthetic process (GO:0042364)2.65913029
159negative regulation of systemic arterial blood pressure (GO:0003085)2.64444518
160male meiosis I (GO:0007141)2.63738870
161metallo-sulfur cluster assembly (GO:0031163)2.58376564
162iron-sulfur cluster assembly (GO:0016226)2.58376564
163oxidative demethylation (GO:0070989)2.57861283
164mitochondrial respiratory chain complex assembly (GO:0033108)2.55459799
165phenol-containing compound catabolic process (GO:0019336)2.54627543
166response to pheromone (GO:0019236)2.53226766
167androgen biosynthetic process (GO:0006702)2.51975424
168arginine metabolic process (GO:0006525)2.51781315
169regulation of histone phosphorylation (GO:0033127)2.50784276
170positive regulation of CREB transcription factor activity (GO:0032793)2.50739264
171dopamine transport (GO:0015872)2.50300271
172proline biosynthetic process (GO:0006561)2.49734369
173GTP biosynthetic process (GO:0006183)2.48733442
174RNA modification (GO:0009451)2.47756234
175UTP biosynthetic process (GO:0006228)2.47464555
176organelle membrane fusion (GO:0090174)2.46702312
177rRNA modification (GO:0000154)2.46444842
178arginine catabolic process (GO:0006527)2.46200263
179regulation of triglyceride metabolic process (GO:0090207)2.45566601
180tRNA processing (GO:0008033)2.41913335

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.43683419
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.88164446
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.63063820
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.46276784
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.98871764
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.90485275
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.89608138
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.70851744
9* LXR_22158963_ChIP-Seq_LIVER_Mouse3.42948147
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.07296912
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.99192564
12GATA1_22025678_ChIP-Seq_K562_Human2.86349217
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.74386290
14E2F7_22180533_ChIP-Seq_HELA_Human2.64084934
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.26153307
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18066617
17ELF1_20517297_ChIP-Seq_JURKAT_Human2.14329418
18P68_20966046_ChIP-Seq_HELA_Human2.10322024
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.08384161
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.97489353
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95248241
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.91086388
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89767311
24E2F1_20622854_ChIP-Seq_HELA_Human1.88616628
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.88452353
26BCOR_27268052_Chip-Seq_Bcells_Human1.83741140
27* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.83322633
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.81703638
29SCL_19346495_ChIP-Seq_HPC-7_Human1.76708295
30PHF8_20622854_ChIP-Seq_HELA_Human1.75663480
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73282685
32YY1_22570637_ChIP-Seq_MALME-3M_Human1.69695063
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.69664245
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.67090645
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.66357424
36TET1_21451524_ChIP-Seq_MESCs_Mouse1.66117379
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.63550730
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.61899099
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.61558416
40EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.59323808
41GATA1_22383799_ChIP-Seq_G1ME_Mouse1.59145578
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.58421673
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54617777
44* GATA1_19941827_ChIP-Seq_MEL_Mouse1.53298887
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52437234
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51387231
47CTCF_20526341_ChIP-Seq_ESCs_Human1.47640054
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47237683
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47005980
50RAC3_21632823_ChIP-Seq_H3396_Human1.46689658
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.45871887
52ERA_21632823_ChIP-Seq_H3396_Human1.44696627
53ZNF263_19887448_ChIP-Seq_K562_Human1.43543030
54ZNF274_21170338_ChIP-Seq_K562_Hela1.42647501
55FOXP1_21924763_ChIP-Seq_HESCs_Human1.40849465
56RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.40131513
57SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.39047621
58* SMC4_20622854_ChIP-Seq_HELA_Human1.37912385
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37333073
60TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.36828588
61CTCF_26484167_Chip-Seq_Bcells_Mouse1.36611217
62* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35354894
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34864660
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34640856
65* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.33866193
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33359854
67CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.31412086
68DCP1A_22483619_ChIP-Seq_HELA_Human1.30084773
69* MYC_22102868_ChIP-Seq_BL_Human1.29303786
70RARB_24833708_ChIP-Seq_LIVER_Mouse1.29216616
71MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28375578
72P300_27268052_Chip-Seq_Bcells_Human1.27532551
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26604282
74CTCF_21964334_ChIP-Seq_BJAB-B_Human1.26535460
75MAF_26560356_Chip-Seq_TH2_Human1.26362232
76GATA1_19941826_ChIP-Seq_K562_Human1.25184579
77XRN2_22483619_ChIP-Seq_HELA_Human1.24413023
78FOXP3_21729870_ChIP-Seq_TREG_Human1.22597684
79* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22155505
80RACK7_27058665_Chip-Seq_MCF-7_Human1.21964403
81MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21685953
82NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20634377
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20566567
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20288079
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.20195370
86SA1_27219007_Chip-Seq_Bcells_Human1.20043558
87MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.19656903
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19275479
89VDR_23849224_ChIP-Seq_CD4+_Human1.18765899
90STAT1_20625510_ChIP-Seq_HELA_Human1.18741947
91VDR_21846776_ChIP-Seq_THP-1_Human1.17275895
92CTCF_18555785_ChIP-Seq_MESCs_Mouse1.17013421
93* NCOR1_26117541_ChIP-Seq_K562_Human1.16694986
94GABP_19822575_ChIP-Seq_HepG2_Human1.15231987
95* RARA_24833708_ChIP-Seq_LIVER_Mouse1.12827046
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12553151
97TAF2_19829295_ChIP-Seq_ESCs_Human1.11648924
98NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10551820
99CLOCK_20551151_ChIP-Seq_293T_Human1.09613520
100STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09595009
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09429004
102P53_21459846_ChIP-Seq_SAOS-2_Human1.09420650
103KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08683357
104OCT4_20526341_ChIP-Seq_ESCs_Human1.07459683
105* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.06710051
106HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06301841
107PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05194164
108TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.04991874
109CTCF_21964334_Chip-Seq_Bcells_Human1.04240394
110VDR_22108803_ChIP-Seq_LS180_Human1.04162898
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04021565
112THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03922376
113FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03899309
114CIITA_25753668_ChIP-Seq_RAJI_Human1.03400362
115CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02594391
116* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02028119
117* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99607828
118SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98744006
119ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97689402
120HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97360746
121STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96075456
122GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95843859
123NOTCH1_21737748_ChIP-Seq_TLL_Human0.94882058
124* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94869488
125SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93809005
126STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93287649
127FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.93077260
128E2F4_17652178_ChIP-ChIP_JURKAT_Human0.92912699
129MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92815070
130BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92720222
131IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91502300
132CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91097283
133LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90862670
134* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87374300
135FOXM1_23109430_ChIP-Seq_U2OS_Human0.85590275
136* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85269859
137* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.84050942
138GATA2_19941826_ChIP-Seq_K562_Human0.82894796
139MYC_19079543_ChIP-ChIP_MESCs_Mouse0.82548101
140SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.81968392
141AR_21909140_ChIP-Seq_LNCAP_Human0.81777130
142YY1_21170310_ChIP-Seq_MESCs_Mouse0.81360999
143SPI1_23547873_ChIP-Seq_NB4_Human0.79972857
144RXRA_24833708_ChIP-Seq_LIVER_Mouse0.78900414
145BCL6_27268052_Chip-Seq_Bcells_Human0.78474902
146LXR_22292898_ChIP-Seq_THP-1_Human0.77917326
147IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.77529109
148CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.76754876
149ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76296541
150RARG_19884340_ChIP-ChIP_MEFs_Mouse0.76241790
151KDM5A_27292631_Chip-Seq_BREAST_Human0.75980847

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.12870215
2MP0005360_urolithiasis5.60384995
3MP0005085_abnormal_gallbladder_physiolo4.67462729
4MP0005365_abnormal_bile_salt4.57510949
5MP0003806_abnormal_nucleotide_metabolis4.35712219
6MP0003656_abnormal_erythrocyte_physiolo4.23983747
7MP0008875_abnormal_xenobiotic_pharmacok4.04716219
8MP0004147_increased_porphyrin_level3.53015545
9MP0009840_abnormal_foam_cell3.05966533
10MP0010329_abnormal_lipoprotein_level2.89660733
11MP0003252_abnormal_bile_duct2.62119705
12MP0005083_abnormal_biliary_tract2.50316208
13MP0005332_abnormal_amino_acid2.40193577
14MP0004233_abnormal_muscle_weight2.39273652
15MP0006036_abnormal_mitochondrial_physio2.26472961
16MP0004145_abnormal_muscle_electrophysio2.26325955
17MP0001666_abnormal_nutrient_absorption2.23233113
18MP0001873_stomach_inflammation2.21852394
19MP0003191_abnormal_cellular_cholesterol2.10601006
20MP0001661_extended_life_span2.09050144
21MP0002876_abnormal_thyroid_physiology2.08086023
22MP0003186_abnormal_redox_activity2.07324261
23MP0000609_abnormal_liver_physiology2.07095003
24MP0003786_premature_aging2.03178536
25MP0005319_abnormal_enzyme/_coenzyme1.98439056
26MP0003195_calcinosis1.93513173
27MP0005167_abnormal_blood-brain_barrier1.87078197
28MP0002118_abnormal_lipid_homeostasis1.81277293
29MP0002163_abnormal_gland_morphology1.80825177
30MP0000678_abnormal_parathyroid_gland1.75264121
31MP0001764_abnormal_homeostasis1.74050852
32MP0006035_abnormal_mitochondrial_morpho1.69889617
33MP0004019_abnormal_vitamin_homeostasis1.69183167
34MP0005584_abnormal_enzyme/coenzyme_acti1.65950272
35MP0003172_abnormal_lysosome_physiology1.59825957
36MP0009643_abnormal_urine_homeostasis1.55026376
37MP0003868_abnormal_feces_composition1.52448324
38MP0005636_abnormal_mineral_homeostasis1.52443816
39MP0003950_abnormal_plasma_membrane1.43446199
40MP0002160_abnormal_reproductive_system1.43077425
41MP0003724_increased_susceptibility_to1.40680742
42MP0001986_abnormal_taste_sensitivity1.40304772
43MP0003959_abnormal_lean_body1.36226585
44MP0008995_early_reproductive_senescence1.33972417
45MP0005551_abnormal_eye_electrophysiolog1.33522468
46MP0000003_abnormal_adipose_tissue1.29852389
47MP0004130_abnormal_muscle_cell1.29150121
48* MP0000598_abnormal_liver_morphology1.28397665
49MP0005646_abnormal_pituitary_gland1.27996074
50MP0008058_abnormal_DNA_repair1.27345806
51MP0000015_abnormal_ear_pigmentation1.24152327
52MP0008469_abnormal_protein_level1.23424968
53MP0002396_abnormal_hematopoietic_system1.23192435
54MP0005451_abnormal_body_composition1.21961266
55MP0000681_abnormal_thyroid_gland1.21490167
56MP0005670_abnormal_white_adipose1.20908888
57MP0000372_irregular_coat_pigmentation1.20817205
58MP0002148_abnormal_hypersensitivity_rea1.20511598
59MP0002138_abnormal_hepatobiliary_system1.17658585
60MP0001853_heart_inflammation1.16988196
61MP0002332_abnormal_exercise_endurance1.14420496
62MP0002837_dystrophic_cardiac_calcinosis1.14034799
63MP0005464_abnormal_platelet_physiology1.14033391
64MP0006054_spinal_hemorrhage1.12351087
65MP0009697_abnormal_copulation1.10206011
66MP0009764_decreased_sensitivity_to1.10131583
67MP0002132_abnormal_respiratory_system1.09785135
68MP0009763_increased_sensitivity_to1.07535113
69MP0005397_hematopoietic_system_phenotyp1.04755801
70MP0001545_abnormal_hematopoietic_system1.04755801
71MP0002971_abnormal_brown_adipose1.03671128
72MP0005389_reproductive_system_phenotype1.03468985
73MP0004858_abnormal_nervous_system1.01686886
74MP0003011_delayed_dark_adaptation0.97970070
75MP0000750_abnormal_muscle_regeneration0.97864940
76MP0005410_abnormal_fertilization0.97622068
77MP0000604_amyloidosis0.95945690
78MP0005266_abnormal_metabolism0.94682053
79MP0005376_homeostasis/metabolism_phenot0.94166537
80MP0000013_abnormal_adipose_tissue0.92270708
81MP0003693_abnormal_embryo_hatching0.92245120
82MP0008961_abnormal_basal_metabolism0.92068051
83MP0002693_abnormal_pancreas_physiology0.91950977
84MP0009642_abnormal_blood_homeostasis0.91832954
85MP0001968_abnormal_touch/_nociception0.90719123
86MP0009333_abnormal_splenocyte_physiolog0.90614950
87MP0005535_abnormal_body_temperature0.90595072
88MP0005058_abnormal_lysosome_morphology0.88264868
89MP0003436_decreased_susceptibility_to0.87054644
90MP0001664_abnormal_digestion0.85316429
91MP0005666_abnormal_adipose_tissue0.85227027
92MP0000685_abnormal_immune_system0.84277333
93MP0003111_abnormal_nucleus_morphology0.83836397
94MP0005379_endocrine/exocrine_gland_phen0.83822645
95MP0001929_abnormal_gametogenesis0.83672379
96MP0003718_maternal_effect0.83197041
97MP0004043_abnormal_pH_regulation0.82827677
98MP0009785_altered_susceptibility_to0.81296951
99MP0002078_abnormal_glucose_homeostasis0.81275037
100MP0000490_abnormal_crypts_of0.81205155
101MP0009765_abnormal_xenobiotic_induced0.81069097
102MP0002210_abnormal_sex_determination0.79525359
103MP0005671_abnormal_response_to0.77995752
104MP0005334_abnormal_fat_pad0.77964646
105MP0005448_abnormal_energy_balance0.77962762
106MP0003646_muscle_fatigue0.77678843
107MP0000749_muscle_degeneration0.76929503
108MP0002970_abnormal_white_adipose0.75895693
109MP0010368_abnormal_lymphatic_system0.75775262
110MP0005330_cardiomyopathy0.75203640
111MP0001835_abnormal_antigen_presentation0.73843232
112MP0003698_abnormal_male_reproductive0.73526990
113MP0002723_abnormal_immune_serum0.72821397
114MP0004133_heterotaxia0.72769707
115MP0004215_abnormal_myocardial_fiber0.72586427
116MP0008775_abnormal_heart_ventricle0.72351712
117MP0003045_fibrosis0.72234973
118MP0001756_abnormal_urination0.72071800
119MP0000689_abnormal_spleen_morphology0.71879277
120MP0001145_abnormal_male_reproductive0.71557542
121MP0001502_abnormal_circadian_rhythm0.71407649
122MP0005310_abnormal_salivary_gland0.71215652
123MP0002168_other_aberrant_phenotype0.70891621
124MP0010094_abnormal_chromosome_stability0.70836419
125MP0000733_abnormal_muscle_development0.70355574
126MP0001905_abnormal_dopamine_level0.68899477
127MP0005220_abnormal_exocrine_pancreas0.68543337
128MP0001845_abnormal_inflammatory_respons0.67162772
129MP0002269_muscular_atrophy0.66732503
130MP0002722_abnormal_immune_system0.65512862
131MP0003705_abnormal_hypodermis_morpholog0.65162633
132MP0002136_abnormal_kidney_physiology0.64883661
133MP0005025_abnormal_response_to0.64798095
134MP0003221_abnormal_cardiomyocyte_apopto0.60038974
135MP0005647_abnormal_sex_gland0.59663853
136MP0008873_increased_physiological_sensi0.59548021
137MP0002419_abnormal_innate_immunity0.57760979
138MP0000465_gastrointestinal_hemorrhage0.57232303
139MP0003329_amyloid_beta_deposits0.56633491
140* MP0002429_abnormal_blood_cell0.56611151
141MP0002254_reproductive_system_inflammat0.55947882
142MP0002398_abnormal_bone_marrow0.55852961
143MP0005084_abnormal_gallbladder_morpholo0.54615573
144MP0000358_abnormal_cell_content/0.54112532
145MP0008872_abnormal_physiological_respon0.53527551
146MP0010155_abnormal_intestine_physiology0.51693344
147MP0000747_muscle_weakness0.48481392
148MP0004084_abnormal_cardiac_muscle0.48405234
149MP0000343_altered_response_to0.47155583
150MP0004957_abnormal_blastocyst_morpholog0.46884012

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)6.50290859
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.21235805
3Intrahepatic cholestasis (HP:0001406)4.48012449
4Deep venous thrombosis (HP:0002625)4.42278548
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.38728875
6Xanthomatosis (HP:0000991)4.17629459
7Hypobetalipoproteinemia (HP:0003563)4.16070117
8Prolonged partial thromboplastin time (HP:0003645)4.14982018
9Poikilocytosis (HP:0004447)4.13357051
10Abnormality of fatty-acid metabolism (HP:0004359)4.09354221
11Hyperammonemia (HP:0001987)3.97167520
12Hypochromic microcytic anemia (HP:0004840)3.90010692
13Hyperbilirubinemia (HP:0002904)3.88555434
14Hyperthyroidism (HP:0000836)3.86356370
15Hyperlipoproteinemia (HP:0010980)3.79283275
16Hypoglycemic coma (HP:0001325)3.72621552
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.71205186
18Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.69927207
19Hyperglycinuria (HP:0003108)3.66250652
20Ketosis (HP:0001946)3.59099951
21Ragged-red muscle fibers (HP:0003200)3.58959671
22Acanthocytosis (HP:0001927)3.54106954
23Reduced antithrombin III activity (HP:0001976)3.50959011
24Decreased activity of mitochondrial respiratory chain (HP:0008972)3.42126263
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.42126263
26Abnormal protein glycosylation (HP:0012346)3.39908907
27Abnormal glycosylation (HP:0012345)3.39908907
28Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.39908907
29Abnormal protein N-linked glycosylation (HP:0012347)3.39908907
30Abnormality of methionine metabolism (HP:0010901)3.38654252
31Abnormality of dicarboxylic acid metabolism (HP:0010995)3.34596790
32Dicarboxylic aciduria (HP:0003215)3.34596790
33Abnormality of serine family amino acid metabolism (HP:0010894)3.33355803
34Abnormality of glycine metabolism (HP:0010895)3.33355803
35Hyperglycinemia (HP:0002154)3.30387386
36Abnormality of sulfur amino acid metabolism (HP:0004339)3.26448614
37Hypolipoproteinemia (HP:0010981)3.25976118
38Abnormality of aspartate family amino acid metabolism (HP:0010899)3.21946452
39Cholelithiasis (HP:0001081)3.18302087
40Reticulocytosis (HP:0001923)3.15252638
41Joint hemorrhage (HP:0005261)3.14704835
42Increased cerebral lipofuscin (HP:0011813)3.11564987
43Clumsiness (HP:0002312)3.09399015
44Protruding tongue (HP:0010808)3.05532952
45Abnormal gallbladder morphology (HP:0012437)3.01680070
46Abnormality of pyrimidine metabolism (HP:0004353)3.01235788
47Thoracic kyphosis (HP:0002942)3.01094065
48Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.00623533
49Abnormality of the common coagulation pathway (HP:0010990)2.98805042
50J-shaped sella turcica (HP:0002680)2.96508483
51Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.96436800
52Metabolic acidosis (HP:0001942)2.94381677
53Hypoalphalipoproteinemia (HP:0003233)2.93311524
54Truncus arteriosus (HP:0001660)2.93110751
55Ketoacidosis (HP:0001993)2.92738143
56Microretrognathia (HP:0000308)2.92394435
57Complement deficiency (HP:0004431)2.91853122
58Cerebral edema (HP:0002181)2.90886870
59Abnormality of glutamine family amino acid metabolism (HP:0010902)2.90159415
60Abnormality of serum amino acid levels (HP:0003112)2.87407173
61Hepatic necrosis (HP:0002605)2.86190667
62Congenital stationary night blindness (HP:0007642)2.82728985
63Abnormality of the intrinsic pathway (HP:0010989)2.82699660
64Abnormality of liposaccharide metabolism (HP:0010968)2.77623046
65Abnormality of glycosphingolipid metabolism (HP:0004343)2.77623046
66Abnormality of glycolipid metabolism (HP:0010969)2.77623046
67Type II lissencephaly (HP:0007260)2.75290508
68Hepatocellular carcinoma (HP:0001402)2.74174182
69Lethargy (HP:0001254)2.73451133
70Type I transferrin isoform profile (HP:0003642)2.72710694
71Generalized aminoaciduria (HP:0002909)2.69983163
72Nausea (HP:0002018)2.69438289
73Hypertensive crisis (HP:0100735)2.67797252
74Hypercholesterolemia (HP:0003124)2.59371367
75Abnormality of iron homeostasis (HP:0011031)2.57433030
76Absent rod-and cone-mediated responses on ERG (HP:0007688)2.56502525
77Microcytic anemia (HP:0001935)2.54297002
78Large for gestational age (HP:0001520)2.52999222
79Abnormality of transition element cation homeostasis (HP:0011030)2.51399065
80Abnormal rod and cone electroretinograms (HP:0008323)2.50987007
81Abnormality of mucopolysaccharide metabolism (HP:0011020)2.50518533
82Abnormality of polysaccharide metabolism (HP:0011012)2.50518533
83Abnormality of glycosaminoglycan metabolism (HP:0004371)2.50518533
84Abnormality of nucleobase metabolism (HP:0010932)2.48977022
85Delayed CNS myelination (HP:0002188)2.47383802
86Testicular atrophy (HP:0000029)2.47348924
87Stridor (HP:0010307)2.45596243
88Vomiting (HP:0002013)2.45449573
89Increased muscle lipid content (HP:0009058)2.45320506
90Cholecystitis (HP:0001082)2.41339516
91Abnormal gallbladder physiology (HP:0012438)2.41339516
92Lactic acidosis (HP:0003128)2.40493207
93Increased serum ferritin (HP:0003281)2.39307381
94Abnormality of the renal cortex (HP:0011035)2.39164122
95Severe visual impairment (HP:0001141)2.37824684
96Fat malabsorption (HP:0002630)2.37809034
97Acute encephalopathy (HP:0006846)2.37796164
98Squamous cell carcinoma (HP:0002860)2.34596248
99Abnormality of reticulocytes (HP:0004312)2.32125740
100Nonimmune hydrops fetalis (HP:0001790)2.31202996
101Opisthotonus (HP:0002179)2.31166768
102Epidermoid cyst (HP:0200040)2.30074064
103Hepatocellular necrosis (HP:0001404)2.29578292
104Myoglobinuria (HP:0002913)2.28216720
105Facial diplegia (HP:0001349)2.26612621
106Conjugated hyperbilirubinemia (HP:0002908)2.25752366
107Abnormal number of erythroid precursors (HP:0012131)2.24101802
108Abnormality of the gallbladder (HP:0005264)2.23359756
109Pendular nystagmus (HP:0012043)2.23327606
110Abnormality of T cell physiology (HP:0011840)2.22933116
111Abnormality of purine metabolism (HP:0004352)2.22847639
112Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22770760
113Abnormality of alanine metabolism (HP:0010916)2.22770760
114Hyperalaninemia (HP:0003348)2.22770760
115Polycythemia (HP:0001901)2.21233879
116Irritability (HP:0000737)2.20167698
117Multiple enchondromatosis (HP:0005701)2.19078840
118Proximal tubulopathy (HP:0000114)2.18673554
119Abnormality of the thoracic spine (HP:0100711)2.16117513
120Urinary glycosaminoglycan excretion (HP:0003541)2.15259178
121Mucopolysacchariduria (HP:0008155)2.15259178
122Brushfield spots (HP:0001088)2.15099732
123Self-mutilation (HP:0000742)2.13787048
124Gout (HP:0001997)2.13654741
125Late onset (HP:0003584)2.13603917
126Progressive microcephaly (HP:0000253)2.13277752
127Rhabdomyolysis (HP:0003201)2.09236625
128Redundant skin (HP:0001582)2.09080413
129Abnormality of cells of the erythroid lineage (HP:0012130)2.08939901
130Increased intramyocellular lipid droplets (HP:0012240)2.08758787
131Bulbous nose (HP:0000414)2.07265444
132Severe muscular hypotonia (HP:0006829)2.06563608
133Mitochondrial inheritance (HP:0001427)2.06441947
134Abnormality of complement system (HP:0005339)2.05665729
135Abnormal cartilage morphology (HP:0002763)2.04235663
136Hypochromic anemia (HP:0001931)2.03371254
137Abnormal mitochondria in muscle tissue (HP:0008316)2.02393479
138Increased serum lactate (HP:0002151)1.99056965
139Increased CSF lactate (HP:0002490)1.97726268
140Hypoplasia of the pons (HP:0012110)1.97709479
141Renal cortical cysts (HP:0000803)1.95861593
142Cerebral palsy (HP:0100021)1.95442860
143Attenuation of retinal blood vessels (HP:0007843)1.93794881
144Albinism (HP:0001022)1.93278987
145Birth length less than 3rd percentile (HP:0003561)1.92124138
146Pancreatic cysts (HP:0001737)1.92115781
147Dysostosis multiplex (HP:0000943)1.92082099
148Abnormality of the pons (HP:0007361)1.92002273
149Elevated hepatic transaminases (HP:0002910)1.91513662
150Concave nail (HP:0001598)1.91299782
151Seborrheic dermatitis (HP:0001051)1.90476156
152Epistaxis (HP:0000421)1.90338311
153Glycosuria (HP:0003076)1.89870223
154Abnormality of urine glucose concentration (HP:0011016)1.89870223
155Ileus (HP:0002595)1.89477455
156Pancreatitis (HP:0001733)1.89112635
157Acute necrotizing encephalopathy (HP:0006965)1.88730158
1583-Methylglutaconic aciduria (HP:0003535)1.86652058
159Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81156303
160Chronic obstructive pulmonary disease (HP:0006510)1.80720755
161Obstructive lung disease (HP:0006536)1.80720755
162Abnormality of the lumbar spine (HP:0100712)1.80257446
163Visual hallucinations (HP:0002367)1.79173733
164Slender long bone (HP:0003100)1.79014869
165Pustule (HP:0200039)1.78868770
166Tinnitus (HP:0000360)1.78588306
167Cerebellar dysplasia (HP:0007033)1.78396006
168Prolonged QT interval (HP:0001657)1.77616969
169Abnormality of subcutaneous fat tissue (HP:0001001)1.75172557
170Aplasia/Hypoplasia of the patella (HP:0006498)1.74562264
171Breast hypoplasia (HP:0003187)1.74127838
172Mesangial abnormality (HP:0001966)1.71949218
173Cortical visual impairment (HP:0100704)1.69480966

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.42566838
2ERN13.69402727
3EIF2AK13.65361261
4NME23.31362115
5FLT33.13695027
6FRK3.02503623
7SIK12.89566973
8TRIB32.84593661
9PKN22.76458442
10STK162.49589135
11VRK22.23164933
12DAPK22.18531829
13IRAK42.12914508
14MAP2K32.02864094
15CAMK1D2.02524211
16MAP4K11.96511300
17SMG11.93655304
18KDR1.91166076
19CAMKK21.83241791
20TAOK31.78070481
21MAP3K111.75724515
22WNK41.74081960
23ADRBK21.71457399
24FGFR41.62820455
25MAPKAPK51.61471984
26TBK11.60986632
27MUSK1.59056712
28BUB11.57112865
29IRAK11.56104847
30PRKD31.49678077
31IRAK21.44239758
32ICK1.43248009
33KIT1.41343435
34TNK21.38039590
35GRK11.37039695
36MAPK111.36074951
37TXK1.35450091
38SCYL21.31910840
39CSF1R1.31714518
40WEE11.28542235
41PDK21.28371172
42TYK21.26332281
43BLK1.26270948
44DAPK11.23898699
45TIE11.23074139
46CDK41.19616815
47ZAP701.18184214
48MAP3K101.16785593
49CDK81.13134355
50EEF2K1.11790662
51GRK61.09092834
52BRSK21.08057165
53EIF2AK31.07860481
54IRAK31.06044213
55ABL21.05735339
56HIPK21.04421868
57NUAK11.02878670
58PINK11.01349672
59RIPK41.01249281
60TGFBR21.00908387
61IKBKE1.00805812
62RPS6KA51.00340403
63MAPK120.99543928
64RPS6KB20.98593786
65CCNB10.96943172
66NEK10.96388954
67RPS6KA60.96333284
68SYK0.95200372
69PIK3CG0.93337159
70VRK10.92402969
71TEC0.91480597
72PRKCI0.90924130
73DAPK30.90239484
74PDPK10.90101699
75TLK10.89888523
76MYLK0.89701877
77JAK20.88322558
78INSRR0.87619935
79PRKAA20.87458669
80PIM20.85894364
81PDK30.82899374
82PDK40.82899374
83EPHA20.82855150
84LRRK20.82530735
85CDK190.82421909
86BRSK10.82138903
87DYRK30.81456201
88BTK0.81015187
89MAP3K70.78102363
90BMPR1B0.77811188
91PRKD20.76586402
92TAF10.75131960
93CDK60.74939666
94MAPKAPK30.74430280
95PIM10.70849314
96JAK30.70721155
97RPS6KA40.69374275
98CAMK1G0.67998224
99PRKG20.67990697
100RPS6KL10.67961721
101RPS6KC10.67961721
102LYN0.65606807
103CHEK20.64726103
104STK240.64526717
105PTK2B0.63545994
106TTN0.63521465
107PHKG20.62178131
108PHKG10.62178131
109STK40.60927132
110MAPK40.59422299
111CAMKK10.58771208
112MAPK130.57017262
113RPS6KA20.56985750
114CDC70.56627025
115ZAK0.55090706
116TAOK20.54149629
117MAP3K80.53216684
118ILK0.52907872
119MAP2K10.52407530
120CHUK0.51425633
121AURKB0.51121297
122TRPM70.51079343
123SIK20.50529519
124DYRK1B0.49903985
125MAP3K140.49107337
126TGFBR10.49102365
127JAK10.48465573
128MAP2K60.48057654
129GRK50.47534795
130MAP3K30.46912703
131IKBKB0.45908658
132MAP3K10.44741058
133NEK20.44199831
134MARK30.43833121
135EPHB10.43811728
136CSNK1G30.43184545
137NEK90.42003153
138PRKACG0.41747046
139ACVR1B0.41580136
140CAMK40.41116463
141TAOK10.40854645
142MAP2K40.37641392
143MAP2K20.37061894
144NME10.36130763
145MAP3K50.33708625
146OBSCN0.33377635
147TTK0.31688135
148PDK10.31317321
149PRKAA10.29390323
150CSNK2A20.29275284
151CSNK2A10.28213786
152MAPK70.26763474
153CAMK10.25025496
154AURKA0.23407812
155PTK60.23259628

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.32018979
2Fatty acid degradation_Homo sapiens_hsa000712.84250325
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.71467330
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.71163248
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.63934483
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.61347567
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.60983833
8Homologous recombination_Homo sapiens_hsa034402.58550226
9Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.44391825
10Propanoate metabolism_Homo sapiens_hsa006402.42412079
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.40624676
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.38442003
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.37473170
14Tryptophan metabolism_Homo sapiens_hsa003802.29905465
15Drug metabolism - other enzymes_Homo sapiens_hsa009832.28326366
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.22803008
17Arginine biosynthesis_Homo sapiens_hsa002202.14018064
18Nitrogen metabolism_Homo sapiens_hsa009102.10376382
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.09127315
20Pentose and glucuronate interconversions_Homo sapiens_hsa000402.08068758
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.06842331
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.05096636
23Peroxisome_Homo sapiens_hsa041461.97997873
24Complement and coagulation cascades_Homo sapiens_hsa046101.95909384
25Fatty acid metabolism_Homo sapiens_hsa012121.85475681
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81839584
27Caffeine metabolism_Homo sapiens_hsa002321.79659399
28Butanoate metabolism_Homo sapiens_hsa006501.78506331
29Carbon metabolism_Homo sapiens_hsa012001.75825618
30PPAR signaling pathway_Homo sapiens_hsa033201.70967826
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.70368990
32Pyruvate metabolism_Homo sapiens_hsa006201.69449175
33Sulfur relay system_Homo sapiens_hsa041221.69356949
34Folate biosynthesis_Homo sapiens_hsa007901.66023375
35beta-Alanine metabolism_Homo sapiens_hsa004101.63759594
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.63221133
37Chemical carcinogenesis_Homo sapiens_hsa052041.56301780
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.53480168
39Biosynthesis of amino acids_Homo sapiens_hsa012301.50104699
40* Selenocompound metabolism_Homo sapiens_hsa004501.49251935
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.42800820
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.41516371
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35448624
44Histidine metabolism_Homo sapiens_hsa003401.31796816
45Ether lipid metabolism_Homo sapiens_hsa005651.31694596
46Fanconi anemia pathway_Homo sapiens_hsa034601.29128162
47Pentose phosphate pathway_Homo sapiens_hsa000301.29056752
48Staphylococcus aureus infection_Homo sapiens_hsa051501.28432754
49Starch and sucrose metabolism_Homo sapiens_hsa005001.27359265
50Lysosome_Homo sapiens_hsa041421.26512802
51ABC transporters_Homo sapiens_hsa020101.24335367
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.24238563
53One carbon pool by folate_Homo sapiens_hsa006701.23348692
54Fatty acid elongation_Homo sapiens_hsa000621.18805205
55Retinol metabolism_Homo sapiens_hsa008301.18427508
56Sulfur metabolism_Homo sapiens_hsa009201.16891431
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15341716
58Tyrosine metabolism_Homo sapiens_hsa003501.15329602
59Phenylalanine metabolism_Homo sapiens_hsa003601.13123285
60Ovarian steroidogenesis_Homo sapiens_hsa049131.12665391
61Fat digestion and absorption_Homo sapiens_hsa049751.11881036
62Vitamin B6 metabolism_Homo sapiens_hsa007501.11151759
63Arachidonic acid metabolism_Homo sapiens_hsa005901.10048169
64DNA replication_Homo sapiens_hsa030301.07125213
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05970870
66Maturity onset diabetes of the young_Homo sapiens_hsa049501.04744110
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04234321
68Cyanoamino acid metabolism_Homo sapiens_hsa004601.01124820
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00877737
70Glutathione metabolism_Homo sapiens_hsa004800.99750124
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93059020
72Bile secretion_Homo sapiens_hsa049760.92877507
73Ribosome_Homo sapiens_hsa030100.91891835
74Arginine and proline metabolism_Homo sapiens_hsa003300.85889165
75Phototransduction_Homo sapiens_hsa047440.84981777
76Proteasome_Homo sapiens_hsa030500.84284962
77* Pyrimidine metabolism_Homo sapiens_hsa002400.83138387
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80414074
79Bladder cancer_Homo sapiens_hsa052190.79385176
80Galactose metabolism_Homo sapiens_hsa000520.75925353
81Fructose and mannose metabolism_Homo sapiens_hsa000510.75657886
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73382675
83Parkinsons disease_Homo sapiens_hsa050120.72213488
84Metabolic pathways_Homo sapiens_hsa011000.71852939
85Vitamin digestion and absorption_Homo sapiens_hsa049770.69633643
86Oxidative phosphorylation_Homo sapiens_hsa001900.67288525
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61909047
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.58306526
89Collecting duct acid secretion_Homo sapiens_hsa049660.58089159
90Lysine degradation_Homo sapiens_hsa003100.57953430
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57567397
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55776990
93Glycerolipid metabolism_Homo sapiens_hsa005610.52215507
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50692693
95Basal transcription factors_Homo sapiens_hsa030220.50641674
96Olfactory transduction_Homo sapiens_hsa047400.50177324
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49744167
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45082557
99Base excision repair_Homo sapiens_hsa034100.42300004
100Non-homologous end-joining_Homo sapiens_hsa034500.39556038
101Sphingolipid metabolism_Homo sapiens_hsa006000.39304177
102VEGF signaling pathway_Homo sapiens_hsa043700.37116745
103Primary immunodeficiency_Homo sapiens_hsa053400.36409471
104Mismatch repair_Homo sapiens_hsa034300.36134351
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.35010245
106Systemic lupus erythematosus_Homo sapiens_hsa053220.33863019
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.32164321
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31490970
109Huntingtons disease_Homo sapiens_hsa050160.30139087
110Alzheimers disease_Homo sapiens_hsa050100.29901949
111Protein export_Homo sapiens_hsa030600.29840648
112Insulin resistance_Homo sapiens_hsa049310.24388397
113Fatty acid biosynthesis_Homo sapiens_hsa000610.23127175
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22105548
115RNA polymerase_Homo sapiens_hsa030200.18657180
116Linoleic acid metabolism_Homo sapiens_hsa005910.18220341
117Purine metabolism_Homo sapiens_hsa002300.16797279
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.16791040
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.16323913
120Legionellosis_Homo sapiens_hsa051340.14811166
121N-Glycan biosynthesis_Homo sapiens_hsa005100.13986870
122Steroid biosynthesis_Homo sapiens_hsa001000.11794147
123Other glycan degradation_Homo sapiens_hsa005110.10975065
124Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.10891827
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.10370499
126Nucleotide excision repair_Homo sapiens_hsa034200.09365147
127Regulation of autophagy_Homo sapiens_hsa041400.08303229

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