TYK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.11600359
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.11600359
3antigen processing and presentation of endogenous antigen (GO:0019883)5.90041249
4positive regulation of gamma-delta T cell activation (GO:0046645)5.39707424
5NIK/NF-kappaB signaling (GO:0038061)4.87779695
6negative regulation of erythrocyte differentiation (GO:0045647)4.65517703
7detection of other organism (GO:0098543)4.64868492
8detection of bacterium (GO:0016045)4.64122770
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.12329972
10regulation of gamma-delta T cell differentiation (GO:0045586)4.09757240
11regulation of gamma-delta T cell activation (GO:0046643)4.05976514
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.87782773
13negative regulation of cell killing (GO:0031342)3.87782773
14detection of external biotic stimulus (GO:0098581)3.84177103
15regulation of interleukin-12 biosynthetic process (GO:0045075)3.77965396
16positive regulation by symbiont of host defense response (GO:0052509)3.68959961
17modulation by symbiont of host defense response (GO:0052031)3.68959961
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.68959961
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.68959961
20positive regulation by organism of defense response of other organism involved in symbiotic interact3.68959961
21modulation by symbiont of host immune response (GO:0052553)3.68959961
22T cell migration (GO:0072678)3.62923397
23positive regulation of interferon-alpha production (GO:0032727)3.61491030
24positive regulation of B cell differentiation (GO:0045579)3.61203442
25negative thymic T cell selection (GO:0045060)3.60379574
26response to muramyl dipeptide (GO:0032495)3.60087157
27positive thymic T cell selection (GO:0045059)3.59758135
28regulation of interferon-beta biosynthetic process (GO:0045357)3.58481917
29regulation of B cell receptor signaling pathway (GO:0050855)3.48500994
30negative regulation of lymphocyte mediated immunity (GO:0002707)3.48373222
31negative T cell selection (GO:0043383)3.45945511
32regulation of interferon-alpha production (GO:0032647)3.45730890
33positive regulation of antigen processing and presentation (GO:0002579)3.43837002
34positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.43510566
35immunoglobulin mediated immune response (GO:0016064)3.42118945
36detection of biotic stimulus (GO:0009595)3.37136072
37detection of molecule of bacterial origin (GO:0032490)3.31928878
38regulation of mast cell degranulation (GO:0043304)3.30598654
39JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.28099531
40negative regulation of leukocyte mediated immunity (GO:0002704)3.26550406
41regulation of B cell differentiation (GO:0045577)3.25334625
42response to host (GO:0075136)3.23282793
43response to host defenses (GO:0052200)3.23282793
44response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.23282793
45neutrophil activation involved in immune response (GO:0002283)3.21454216
46* response to type I interferon (GO:0034340)3.20961000
47natural killer cell mediated immunity (GO:0002228)3.20559482
48natural killer cell mediated cytotoxicity (GO:0042267)3.20559482
49antigen processing and presentation via MHC class Ib (GO:0002475)3.19643627
50regulation of myeloid leukocyte mediated immunity (GO:0002886)3.16403823
51* type I interferon signaling pathway (GO:0060337)3.16174130
52* cellular response to type I interferon (GO:0071357)3.16174130
53regulation of leukocyte degranulation (GO:0043300)3.13936762
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.12734125
55thymic T cell selection (GO:0045061)3.11893833
56negative regulation of T cell mediated immunity (GO:0002710)3.11078065
57macrophage activation involved in immune response (GO:0002281)3.09659301
58positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.09233036
59* regulation of type I interferon-mediated signaling pathway (GO:0060338)3.05580695
60interferon-gamma-mediated signaling pathway (GO:0060333)3.04153306
61negative regulation of interleukin-12 production (GO:0032695)3.03708348
62positive regulation of natural killer cell differentiation (GO:0032825)3.03469389
63regulation of alpha-beta T cell proliferation (GO:0046640)3.01102662
64myeloid dendritic cell differentiation (GO:0043011)3.00973327
65regulation of dendritic cell antigen processing and presentation (GO:0002604)2.98339082
66leukocyte aggregation (GO:0070486)2.96219833
67regulation of mast cell activation involved in immune response (GO:0033006)2.95653842
68neutrophil activation (GO:0042119)2.95222857
69response to peptidoglycan (GO:0032494)2.95152136
70positive regulation of humoral immune response (GO:0002922)2.93434723
71myeloid dendritic cell activation (GO:0001773)2.93327353
72positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.93213855
73regulation of antigen processing and presentation (GO:0002577)2.89897353
74B cell receptor signaling pathway (GO:0050853)2.89337619
75positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.89027259
76granulocyte activation (GO:0036230)2.88883159
77positive regulation of interferon-beta production (GO:0032728)2.88483949
78T cell selection (GO:0045058)2.86328013
79macrophage activation (GO:0042116)2.86148244
80regulation of response to interferon-gamma (GO:0060330)2.85609006
81response to protozoan (GO:0001562)2.84324928
82regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.83143852
83negative regulation of phagocytosis (GO:0050765)2.81218938
84tolerance induction (GO:0002507)2.79667146
85regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.78078934
86microglial cell activation (GO:0001774)2.76956860
87natural killer cell differentiation (GO:0001779)2.75944104
88regulation of RIG-I signaling pathway (GO:0039535)2.75321757
89regulation of tolerance induction (GO:0002643)2.74011979
90negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.73941996
91cellular response to zinc ion (GO:0071294)2.72031946
92respiratory burst (GO:0045730)2.71555257
93regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.71502582
94regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.70757837
95B cell homeostasis (GO:0001782)2.70522610
96cellular response to interleukin-15 (GO:0071350)2.69876137
97response to interleukin-15 (GO:0070672)2.69820462
98positive regulation of Cdc42 GTPase activity (GO:0043089)2.69033024
99B cell mediated immunity (GO:0019724)2.68481517
100regulation of T-helper 2 cell differentiation (GO:0045628)2.67727498
101negative regulation of cytokine production involved in immune response (GO:0002719)2.66531565
102leukocyte cell-cell adhesion (GO:0007159)2.66531056
103negative regulation of toll-like receptor signaling pathway (GO:0034122)2.66483220
104regulation of hypersensitivity (GO:0002883)2.65389519
105growth hormone receptor signaling pathway (GO:0060396)2.64420229
106regulation of T cell tolerance induction (GO:0002664)2.63958587
107negative regulation of interleukin-6 production (GO:0032715)2.63854254
108negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.62968102
109Arp2/3 complex-mediated actin nucleation (GO:0034314)2.62435925
110T-helper 1 type immune response (GO:0042088)2.62238640
111germinal center formation (GO:0002467)2.62106401
112mature B cell differentiation (GO:0002335)2.61463776
113positive regulation of cellular amide metabolic process (GO:0034250)2.60795815
114positive regulation of interleukin-2 production (GO:0032743)2.59561568
115regulation of mast cell activation (GO:0033003)2.58903479
116dendritic cell differentiation (GO:0097028)2.58723278
117positive regulation of alpha-beta T cell proliferation (GO:0046641)2.53511301
118cellular extravasation (GO:0045123)2.53178840
119positive T cell selection (GO:0043368)2.51991539
120regulation of cholesterol storage (GO:0010885)2.50330341
121defense response to protozoan (GO:0042832)2.47950132
122negative regulation of innate immune response (GO:0045824)2.47905257
123regulation of interleukin-12 production (GO:0032655)2.47256334
124myeloid cell activation involved in immune response (GO:0002275)2.46879131
125leukocyte mediated cytotoxicity (GO:0001909)2.46509439
126lipopolysaccharide-mediated signaling pathway (GO:0031663)2.45789990
127pinocytosis (GO:0006907)2.45549935
128mannose metabolic process (GO:0006013)2.44657245
129cytokine secretion (GO:0050663)2.44529232
130regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.42987482
131response to host immune response (GO:0052572)2.39971243
132response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.39971243
133regulation of interferon-beta production (GO:0032648)2.39045092
134regulation of T-helper 1 cell differentiation (GO:0045625)2.38875189
135regulation of necroptotic process (GO:0060544)2.38443185
136positive regulation of interleukin-12 production (GO:0032735)2.37901070

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.90980259
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.82636284
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.16331824
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.14126695
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.10478218
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.05985792
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.96867674
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.89372311
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.86113833
10* IRF8_27001747_Chip-Seq_BMDM_Mouse2.80554135
11E2F7_22180533_ChIP-Seq_HELA_Human2.75957051
12MYC_22102868_ChIP-Seq_BL_Human2.74252415
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69073828
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.61438929
15* VDR_21846776_ChIP-Seq_THP-1_Human2.49448838
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.45115378
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.37002932
18MAF_26560356_Chip-Seq_TH1_Human2.24070645
19* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.20770586
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.20111305
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.14367983
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.12805722
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.10713700
24BRD4_27068464_Chip-Seq_AML-cells_Mouse2.09774838
25* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.09227426
26MYB_26560356_Chip-Seq_TH2_Human2.04202095
27GATA1_22025678_ChIP-Seq_K562_Human2.00905664
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.00531498
29MYB_26560356_Chip-Seq_TH1_Human1.95774929
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.95089701
31TCF7_22412390_ChIP-Seq_EML_Mouse1.94034459
32SCL_19346495_ChIP-Seq_HPC-7_Human1.91229804
33* SPI1_23547873_ChIP-Seq_NB4_Human1.86540549
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.83081175
35UTX_26944678_Chip-Seq_JUKART_Human1.81270438
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.80863755
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79100562
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.78863868
39* RUNX_20019798_ChIP-Seq_JUKART_Human1.77319147
40* VDR_24763502_ChIP-Seq_THP-1_Human1.75717025
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.74193041
42* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71677417
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.62913495
44RXR_22158963_ChIP-Seq_LIVER_Mouse1.61473944
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60593476
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60102320
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.56839141
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56154555
49SPI1_23127762_ChIP-Seq_K562_Human1.52672736
50KDM2B_26808549_Chip-Seq_DND41_Human1.51141155
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.49003052
52MAF_26560356_Chip-Seq_TH2_Human1.46345817
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42298070
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39852108
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38966583
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38441895
57CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35694811
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.32111113
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30574329
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30016493
61PU_27001747_Chip-Seq_BMDM_Mouse1.29872420
62GATA3_27048872_Chip-Seq_THYMUS_Human1.29776070
63LXR_22158963_ChIP-Seq_LIVER_Mouse1.28751539
64P68_20966046_ChIP-Seq_HELA_Human1.28427190
65BCOR_27268052_Chip-Seq_Bcells_Human1.28110412
66BCL6_27268052_Chip-Seq_Bcells_Human1.26609564
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.26462258
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26201205
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25559031
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.25292245
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24008354
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23484644
73* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22797003
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22597848
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22539356
76KDM2B_26808549_Chip-Seq_K562_Human1.21932074
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20227974
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19711943
79EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17156213
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15094457
81* GATA1_19941827_ChIP-Seq_MEL_Mouse1.12028453
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09839900
83SMC4_20622854_ChIP-Seq_HELA_Human1.08864530
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06420430
85NCOR1_26117541_ChIP-Seq_K562_Human1.05626612
86* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05053635
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04248609
88IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04186281
89EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03328021
90TFEB_21752829_ChIP-Seq_HELA_Human1.02256272
91STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01085241
92LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00832605
93LXR_22292898_ChIP-Seq_THP-1_Human0.99880732
94EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99840435
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99608761
96TP63_17297297_ChIP-ChIP_HaCaT_Human0.98503722
97TET1_21451524_ChIP-Seq_MESCs_Mouse0.98191955
98GATA3_26560356_Chip-Seq_TH2_Human0.97121571
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95984411
100NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95556755
101SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94552098
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93148179
103RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92912024
104CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92802853
105CIITA_25753668_ChIP-Seq_RAJI_Human0.92743631
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91759625
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90255131
108NOTCH1_21737748_ChIP-Seq_TLL_Human0.89863392
109CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89338637
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88979963
111TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88810274
112GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88148922
113GATA1_19941826_ChIP-Seq_K562_Human0.86860246
114PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86787245
115PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86307927
116RACK7_27058665_Chip-Seq_MCF-7_Human0.84700539
117VDR_24787735_ChIP-Seq_THP-1_Human0.84621150
118FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.83214353
119KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82955708
120FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80555501

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.76755440
2MP0000685_abnormal_immune_system3.18635504
3MP0005387_immune_system_phenotype2.85103184
4MP0001790_abnormal_immune_system2.85103184
5MP0003303_peritoneal_inflammation2.78897666
6* MP0001800_abnormal_humoral_immune2.70004618
7* MP0003436_decreased_susceptibility_to2.67995182
8MP0009785_altered_susceptibility_to2.53942726
9MP0005671_abnormal_response_to2.48877043
10* MP0005000_abnormal_immune_tolerance2.42804302
11* MP0002452_abnormal_antigen_presenting2.40236720
12* MP0005025_abnormal_response_to2.33156043
13MP0009840_abnormal_foam_cell2.31821221
14* MP0002723_abnormal_immune_serum2.30758679
15MP0002419_abnormal_innate_immunity2.29825156
16MP0002166_altered_tumor_susceptibility2.24239670
17MP0004510_myositis2.18134919
18* MP0001819_abnormal_immune_cell2.16402729
19* MP0002420_abnormal_adaptive_immunity2.15685692
20MP0006082_CNS_inflammation2.11487917
21MP0008260_abnormal_autophagy2.10699889
22MP0003300_gastrointestinal_ulcer2.08789270
23MP0002148_abnormal_hypersensitivity_rea2.06608691
24MP0005058_abnormal_lysosome_morphology1.95962140
25MP0004947_skin_inflammation1.95615800
26MP0003763_abnormal_thymus_physiology1.93623259
27* MP0002398_abnormal_bone_marrow1.93533534
28MP0005464_abnormal_platelet_physiology1.92083933
29MP0002138_abnormal_hepatobiliary_system1.87078442
30MP0002405_respiratory_system_inflammati1.86490480
31* MP0000716_abnormal_immune_system1.82133829
32MP0003191_abnormal_cellular_cholesterol1.82000298
33MP0001873_stomach_inflammation1.81219583
34MP0002006_tumorigenesis1.75119054
35MP0010155_abnormal_intestine_physiology1.73034934
36MP0000689_abnormal_spleen_morphology1.66655425
37MP0009333_abnormal_splenocyte_physiolog1.66155748
38MP0001845_abnormal_inflammatory_respons1.64989696
39MP0002254_reproductive_system_inflammat1.64520389
40MP0003172_abnormal_lysosome_physiology1.60106029
41MP0002722_abnormal_immune_system1.59740033
42MP0003724_increased_susceptibility_to1.58797873
43MP0001853_heart_inflammation1.57549466
44MP0002396_abnormal_hematopoietic_system1.56979267
45* MP0002429_abnormal_blood_cell1.54653054
46MP0010352_gastrointestinal_tract_polyps1.54498316
47MP0009278_abnormal_bone_marrow1.52498079
48MP0002132_abnormal_respiratory_system1.51964312
49* MP0008469_abnormal_protein_level1.46744506
50MP0005397_hematopoietic_system_phenotyp1.43022660
51MP0001545_abnormal_hematopoietic_system1.43022660
52MP0003705_abnormal_hypodermis_morpholog1.41593182
53MP0003828_pulmonary_edema1.40921783
54MP0005310_abnormal_salivary_gland1.39725743
55MP0000569_abnormal_digit_pigmentation1.37859878
56MP0004381_abnormal_hair_follicle1.36906247
57MP0005076_abnormal_cell_differentiation1.35415641
58MP0003448_altered_tumor_morphology1.33449593
59MP0010307_abnormal_tumor_latency1.32439974
60MP0005360_urolithiasis1.31543371
61* MP0001533_abnormal_skeleton_physiology1.27650491
62MP0004808_abnormal_hematopoietic_stem1.23770451
63MP0003183_abnormal_peptide_metabolism1.22106749
64MP0000703_abnormal_thymus_morphology1.21830689
65MP0003566_abnormal_cell_adhesion1.19982009
66MP0000609_abnormal_liver_physiology1.19946410
67MP0000604_amyloidosis1.12919292
68MP0000858_altered_metastatic_potential1.12792531
69MP0003866_abnormal_defecation1.10673381
70MP0000465_gastrointestinal_hemorrhage1.08881502
71MP0002139_abnormal_hepatobiliary_system1.05739963
72MP0009764_decreased_sensitivity_to1.03511386
73MP0003453_abnormal_keratinocyte_physiol1.02797031
74MP0005365_abnormal_bile_salt1.00098578
75MP0009763_increased_sensitivity_to0.99328574
76MP0004883_abnormal_blood_vessel0.98899375
77MP0005083_abnormal_biliary_tract0.95230457
78MP0002933_joint_inflammation0.95146805
79MP0003690_abnormal_glial_cell0.94581542
80MP0000490_abnormal_crypts_of0.94455264
81MP0005023_abnormal_wound_healing0.90539864
82MP0001849_ear_inflammation0.87653647
83MP0001348_abnormal_lacrimal_gland0.87319257
84MP0003252_abnormal_bile_duct0.87194355
85MP0002998_abnormal_bone_remodeling0.87119229
86MP0005174_abnormal_tail_pigmentation0.87098867
87MP0003091_abnormal_cell_migration0.86650531
88MP0000343_altered_response_to0.85365319
89MP0002019_abnormal_tumor_incidence0.83657639
90MP0003656_abnormal_erythrocyte_physiolo0.83599474
91MP0001663_abnormal_digestive_system0.83376361
92MP0000598_abnormal_liver_morphology0.81472574
93MP0005164_abnormal_response_to0.79910563
94MP0010329_abnormal_lipoprotein_level0.79505676
95* MP0005390_skeleton_phenotype0.78496723
96MP0000371_diluted_coat_color0.78300070
97MP0003075_altered_response_to0.77089848
98MP0001958_emphysema0.75431671
99MP0002009_preneoplasia0.74732311
100MP0002136_abnormal_kidney_physiology0.74609352
101MP0003045_fibrosis0.73704149
102MP0005319_abnormal_enzyme/_coenzyme0.73456599
103MP0000249_abnormal_blood_vessel0.73043299
104MP0003279_aneurysm0.72879871
105MP0002877_abnormal_melanocyte_morpholog0.71574490
106MP0003795_abnormal_bone_structure0.71249710
107MP0005166_decreased_susceptibility_to0.70095140
108MP0008057_abnormal_DNA_replication0.68539030
109MP0001851_eye_inflammation0.68367406
110MP0008874_decreased_physiological_sensi0.67150121
111MP0004185_abnormal_adipocyte_glucose0.67138786
112MP0008004_abnormal_stomach_pH0.64413146
113MP0005666_abnormal_adipose_tissue0.62868775
114MP0000015_abnormal_ear_pigmentation0.60333857
115MP0004858_abnormal_nervous_system0.59640372
116MP0009643_abnormal_urine_homeostasis0.59575683
117MP0005085_abnormal_gallbladder_physiolo0.59294786
118MP0001915_intracranial_hemorrhage0.59065945
119MP0005621_abnormal_cell_physiology0.58826422
120MP0005451_abnormal_body_composition0.58144390

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.07038800
2Recurrent abscess formation (HP:0002722)4.82354602
3Recurrent bacterial skin infections (HP:0005406)4.60421522
4Chronic otitis media (HP:0000389)3.96542606
5Recurrent gram-negative bacterial infections (HP:0005420)3.90589002
6* Recurrent fungal infections (HP:0002841)3.77559237
7Nasal polyposis (HP:0100582)3.73019723
8Elevated erythrocyte sedimentation rate (HP:0003565)3.72587065
9* Recurrent viral infections (HP:0004429)3.70661813
10Colitis (HP:0002583)3.63788941
11Autoimmune thrombocytopenia (HP:0001973)3.53368737
12Pustule (HP:0200039)3.52496888
13Myositis (HP:0100614)3.50678183
14Abnormality of macrophages (HP:0004311)3.45187748
15Recurrent skin infections (HP:0001581)3.38986656
16Abnormality of the nasal mucosa (HP:0000433)3.35039065
17Mediastinal lymphadenopathy (HP:0100721)3.33898907
18Inflammation of the large intestine (HP:0002037)3.24004165
19Gastrointestinal inflammation (HP:0004386)3.16109824
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.08268055
21Myocardial infarction (HP:0001658)3.08214075
22Chronic mucocutaneous candidiasis (HP:0002728)3.05877539
23Recurrent cutaneous fungal infections (HP:0011370)3.05877539
24Recurrent bronchitis (HP:0002837)3.02428612
25Periodontitis (HP:0000704)3.01186261
26Vasculitis (HP:0002633)2.99021917
27Cellulitis (HP:0100658)2.95047520
28Orchitis (HP:0100796)2.94381472
29Systemic lupus erythematosus (HP:0002725)2.83534521
30Gingivitis (HP:0000230)2.81670060
31Increased cerebral lipofuscin (HP:0011813)2.81389808
32Gingival bleeding (HP:0000225)2.78494805
33Hematochezia (HP:0002573)2.73128035
34IgM deficiency (HP:0002850)2.73056688
35Optic neuritis (HP:0100653)2.68518963
36Retrobulbar optic neuritis (HP:0100654)2.68518963
37Arterial thrombosis (HP:0004420)2.66246753
38Abnormality of the fingertips (HP:0001211)2.66107530
39Meningitis (HP:0001287)2.64704732
40Thrombocytosis (HP:0001894)2.64180542
41Abnormality of T cell number (HP:0011839)2.61276698
42Fatigue (HP:0012378)2.61230373
43Spontaneous hematomas (HP:0007420)2.60345868
44T lymphocytopenia (HP:0005403)2.59105655
45Vacuolated lymphocytes (HP:0001922)2.56337797
46Abnormality of T cells (HP:0002843)2.54402457
47Agammaglobulinemia (HP:0004432)2.51206287
48Interstitial pulmonary disease (HP:0006530)2.49893366
49Gastrointestinal infarctions (HP:0005244)2.49689443
50Panhypogammaglobulinemia (HP:0003139)2.48091317
51Abnormality of T cell physiology (HP:0011840)2.46848693
52Stomatitis (HP:0010280)2.46515419
53Increased neuronal autofluorescent lipopigment (HP:0002074)2.46365718
54Epistaxis (HP:0000421)2.43092679
55Leukocytosis (HP:0001974)2.42491721
56Pulmonary infiltrates (HP:0002113)2.38100974
57Obstructive lung disease (HP:0006536)2.35464600
58Chronic obstructive pulmonary disease (HP:0006510)2.35464600
59Emphysema (HP:0002097)2.32273753
60Osteolytic defects of the phalanges of the hand (HP:0009771)2.28958239
61Osteolytic defects of the hand bones (HP:0009699)2.28958239
62Hypochromic anemia (HP:0001931)2.27769550
63Viral hepatitis (HP:0006562)2.24578151
64Osteomyelitis (HP:0002754)2.24170933
65Polycythemia (HP:0001901)2.24119181
66Eosinophilia (HP:0001880)2.20844591
67Hemoptysis (HP:0002105)2.20108244
68Keratoconjunctivitis (HP:0001096)2.19372352
69Broad face (HP:0000283)2.16666542
70Lymphopenia (HP:0001888)2.15866556
71Amyloidosis (HP:0011034)2.15442838
72Abnormality of cells of the lymphoid lineage (HP:0012140)2.15338068
73Abnormality of the peritoneum (HP:0002585)2.15252654
74* Increased IgE level (HP:0003212)2.14660524
75Prolonged bleeding time (HP:0003010)2.14123080
76Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.12608776
77Glomerulonephritis (HP:0000099)2.11739001
78Esophageal varix (HP:0002040)2.11480215
79Urticaria (HP:0001025)2.10013252
80Chest pain (HP:0100749)2.09448245
81Impaired platelet aggregation (HP:0003540)2.07887445
82Abnormal platelet function (HP:0011869)2.07887445
83Hemorrhage of the eye (HP:0011885)2.07847052
84Complement deficiency (HP:0004431)2.06931512
85Sepsis (HP:0100806)2.04874977
86Skin ulcer (HP:0200042)2.04544571
87Loss of speech (HP:0002371)2.04429972
88Purpura (HP:0000979)2.04332685
89Abnormal platelet volume (HP:0011876)2.04238212
90Papilloma (HP:0012740)2.02806414
91Verrucae (HP:0200043)2.02806414
92Gastrointestinal stroma tumor (HP:0100723)2.02259892
93Hypertensive crisis (HP:0100735)2.01732606
94Granulocytopenia (HP:0001913)2.01291675
95Episodic fever (HP:0001954)2.00089684
96Increased IgM level (HP:0003496)1.99641368
97IgA deficiency (HP:0002720)1.99126047
98Obstructive sleep apnea (HP:0002870)1.98220053
99Petechiae (HP:0000967)1.97182952
100Malnutrition (HP:0004395)1.96882531
101Slow saccadic eye movements (HP:0000514)1.95543037
102Polygenic inheritance (HP:0010982)1.95522474
103Dysostosis multiplex (HP:0000943)1.93578640
104Segmental peripheral demyelination/remyelination (HP:0003481)1.93390811
105Premature loss of primary teeth (HP:0006323)1.92877161
106Encephalitis (HP:0002383)1.92259738
107Joint hemorrhage (HP:0005261)1.92248964
108Recurrent lower respiratory tract infections (HP:0002783)1.91531805
109Increased serum ferritin (HP:0003281)1.91283944
110Pulmonary embolism (HP:0002204)1.90439147
111Chronic diarrhea (HP:0002028)1.90297042
112Hepatosplenomegaly (HP:0001433)1.90289167
113Deep venous thrombosis (HP:0002625)1.89633680
114Frequent falls (HP:0002359)1.89304748
115Keratoconjunctivitis sicca (HP:0001097)1.88652836
116Thrombophlebitis (HP:0004418)1.88421739
117Abnormality of the pleura (HP:0002103)1.86401333
118Abnormality of complement system (HP:0005339)1.85360363
119Restrictive lung disease (HP:0002091)1.84385476
120Peritonitis (HP:0002586)1.83836833
121Mucopolysacchariduria (HP:0008155)1.83671313
122Urinary glycosaminoglycan excretion (HP:0003541)1.83671313
123Recurrent sinusitis (HP:0011108)1.83058228
124Cerebral aneurysm (HP:0004944)1.82756324
125Metaphyseal cupping (HP:0003021)1.82524420
126Abnormality of glycosphingolipid metabolism (HP:0004343)1.80889429

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.13573317
2PRPF4B3.57326575
3* TYK23.08708733
4MAP3K143.08213939
5JAK32.72170614
6ERN12.65930234
7TBK12.58936876
8BLK2.42020719
9IKBKE2.31992319
10MAP3K102.24067696
11SMG12.23670041
12FGFR42.22272225
13MAP3K132.22130856
14TRIB32.13274723
15STK102.05743775
16* JAK12.03874785
17EPHB11.98383543
18IRAK31.96084624
19PKN21.94263938
20IKBKB1.94114418
21IRAK41.92486637
22KIT1.88446295
23TNK21.86793159
24EEF2K1.86672097
25ZAP701.85159987
26TAOK31.80790428
27TXK1.65609890
28CDK121.63405891
29CSF1R1.63011200
30RIPK41.61870276
31GRK61.52228986
32CSK1.48729544
33CHUK1.42943964
34FLT31.41371596
35LRRK21.37325052
36RPS6KA41.33869118
37PTK61.31176397
38TTN1.30535778
39BTK1.30026545
40SIK31.28976960
41SYK1.27966120
42FGFR31.25850121
43HCK1.23652570
44JAK21.23472181
45MARK21.23182411
46TGFBR21.18369176
47PIM11.18176349
48LCK1.17927292
49MAP3K11.15413195
50ICK1.15228845
51SIK11.14521353
52PRKD21.14206039
53CDC42BPA1.13210619
54ITK1.13206892
55SIK21.09685309
56KSR21.06514685
57MAP2K31.06293488
58TAOK21.03659476
59NEK21.02535180
60MARK30.95196368
61CDK40.90167167
62MAP3K60.88301597
63EPHA30.86945614
64CAMK1D0.85792234
65MAPK120.85765886
66RIPK10.82076865
67MAPK70.77572216
68LYN0.77049161
69STK40.76250196
70CDK60.74746737
71TEC0.71353917
72BMX0.70648462
73MAP3K80.68309813
74IRAK20.66469258
75MAPK110.65768015
76CAMKK10.65175015
77FES0.64276874
78NEK90.63745375
79NLK0.62946640
80PAK40.58702819
81RPS6KA20.56816638
82SCYL20.56553268
83ALK0.55229481
84KDR0.54489028
85RET0.53017163
86BMPR20.51886309
87PRKAA20.49882656
88STK30.48912195
89MTOR0.47825904
90TESK20.47344513
91PDK10.46780747
92PIM20.46443094
93PRKCQ0.46216675
94TRPM70.45690839
95YES10.45661501
96EGFR0.45333727
97RPS6KA60.45001880
98MAP2K20.44657690
99MAP3K70.43243746
100MAPKAPK20.43156661
101MAP3K110.42816893
102DYRK1B0.42669154
103NME20.42462951
104ABL10.42099296
105MATK0.41531281
106CAMK1G0.40583130
107* FYN0.39704703
108CLK10.39265777
109PASK0.37230777
110IRAK10.37222999
111MAP2K60.36881702
112PDGFRB0.36870243
113MAP3K30.36511831
114FGR0.36327420
115MAPK40.35902246
116SGK30.35226335
117MELK0.35074630
118RPS6KA10.33746167
119RPS6KB20.33385471
120RPS6KL10.32558231
121RPS6KC10.32558231
122TAOK10.32091248
123HIPK20.30386631
124MAPKAPK30.28785133
125PDPK10.28327472
126CDK90.27275788

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.78626698
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.72919991
3Staphylococcus aureus infection_Homo sapiens_hsa051502.72516295
4Primary immunodeficiency_Homo sapiens_hsa053402.48430185
5B cell receptor signaling pathway_Homo sapiens_hsa046622.35016835
6* Osteoclast differentiation_Homo sapiens_hsa043802.29121645
7* Measles_Homo sapiens_hsa051622.23707407
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.17273811
9Antigen processing and presentation_Homo sapiens_hsa046122.10122664
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.00278932
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.94908856
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.89553925
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83523699
14* Herpes simplex infection_Homo sapiens_hsa051681.68871919
15* Influenza A_Homo sapiens_hsa051641.67758757
16* Toxoplasmosis_Homo sapiens_hsa051451.66118002
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64442826
18Legionellosis_Homo sapiens_hsa051341.59520229
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59155839
20Graft-versus-host disease_Homo sapiens_hsa053321.58981953
21Allograft rejection_Homo sapiens_hsa053301.57717919
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.56753164
23TNF signaling pathway_Homo sapiens_hsa046681.56185143
24Apoptosis_Homo sapiens_hsa042101.55004233
25Tuberculosis_Homo sapiens_hsa051521.54686964
26T cell receptor signaling pathway_Homo sapiens_hsa046601.54469286
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53833005
28* Jak-STAT signaling pathway_Homo sapiens_hsa046301.50069149
29Hematopoietic cell lineage_Homo sapiens_hsa046401.44839757
30Pertussis_Homo sapiens_hsa051331.40567931
31Acute myeloid leukemia_Homo sapiens_hsa052211.39783247
32Malaria_Homo sapiens_hsa051441.27179748
33Chemokine signaling pathway_Homo sapiens_hsa040621.24928334
34Shigellosis_Homo sapiens_hsa051311.24396824
35Complement and coagulation cascades_Homo sapiens_hsa046101.21136660
36Caffeine metabolism_Homo sapiens_hsa002321.20347296
37Hepatitis B_Homo sapiens_hsa051611.20064521
38Viral myocarditis_Homo sapiens_hsa054161.19183262
39Chronic myeloid leukemia_Homo sapiens_hsa052201.17881901
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15016568
41Lysosome_Homo sapiens_hsa041421.14680201
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12889889
43Other glycan degradation_Homo sapiens_hsa005111.11863146
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.09829770
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.09759157
46Small cell lung cancer_Homo sapiens_hsa052221.01125289
47* Hepatitis C_Homo sapiens_hsa051601.00576479
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.99440645
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.96788985
50Pancreatic cancer_Homo sapiens_hsa052120.96509330
51ABC transporters_Homo sapiens_hsa020100.95996776
52Renal cell carcinoma_Homo sapiens_hsa052110.95449100
53Insulin resistance_Homo sapiens_hsa049310.91555116
54Asthma_Homo sapiens_hsa053100.88213215
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86039265
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.85985338
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84054631
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83756265
59Viral carcinogenesis_Homo sapiens_hsa052030.83349328
60* Epstein-Barr virus infection_Homo sapiens_hsa051690.82995859
61Lysine degradation_Homo sapiens_hsa003100.82065152
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82057113
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79701121
64Choline metabolism in cancer_Homo sapiens_hsa052310.79063560
65GnRH signaling pathway_Homo sapiens_hsa049120.78807370
66Endometrial cancer_Homo sapiens_hsa052130.78734730
67Arginine biosynthesis_Homo sapiens_hsa002200.77291342
68Salmonella infection_Homo sapiens_hsa051320.77098340
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76638852
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75317283
71Prolactin signaling pathway_Homo sapiens_hsa049170.74986993
72Platelet activation_Homo sapiens_hsa046110.74524008
73Selenocompound metabolism_Homo sapiens_hsa004500.70070597
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69973876
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.69361691
76Inositol phosphate metabolism_Homo sapiens_hsa005620.68962032
77HTLV-I infection_Homo sapiens_hsa051660.68144748
78Bladder cancer_Homo sapiens_hsa052190.66767863
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.64620607
80Colorectal cancer_Homo sapiens_hsa052100.63624337
81Notch signaling pathway_Homo sapiens_hsa043300.63242410
82Pentose phosphate pathway_Homo sapiens_hsa000300.63201148
83Nitrogen metabolism_Homo sapiens_hsa009100.62573762
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62478348
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61628144
86One carbon pool by folate_Homo sapiens_hsa006700.61397058
87p53 signaling pathway_Homo sapiens_hsa041150.60832343
88Autoimmune thyroid disease_Homo sapiens_hsa053200.60382785
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57830935
90mTOR signaling pathway_Homo sapiens_hsa041500.57713591
91Glioma_Homo sapiens_hsa052140.57651371
92VEGF signaling pathway_Homo sapiens_hsa043700.57505589
93ErbB signaling pathway_Homo sapiens_hsa040120.56722613
94African trypanosomiasis_Homo sapiens_hsa051430.55176605
95Prostate cancer_Homo sapiens_hsa052150.54838971
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.54359835
97Insulin signaling pathway_Homo sapiens_hsa049100.53980359
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52174016
99Amoebiasis_Homo sapiens_hsa051460.51900994
100HIF-1 signaling pathway_Homo sapiens_hsa040660.50242799
101Estrogen signaling pathway_Homo sapiens_hsa049150.50208486
102Non-small cell lung cancer_Homo sapiens_hsa052230.50205189
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.50077119
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49391599
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49222474
106MAPK signaling pathway_Homo sapiens_hsa040100.48843294
107Rheumatoid arthritis_Homo sapiens_hsa053230.47850565
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46714665
109Prion diseases_Homo sapiens_hsa050200.46554680
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.45156464
111PPAR signaling pathway_Homo sapiens_hsa033200.44629048
112Tryptophan metabolism_Homo sapiens_hsa003800.41448035
113MicroRNAs in cancer_Homo sapiens_hsa052060.38357871
114FoxO signaling pathway_Homo sapiens_hsa040680.35716390
115Fatty acid degradation_Homo sapiens_hsa000710.33828031
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33407442
117Proteoglycans in cancer_Homo sapiens_hsa052050.31031707
118Phagosome_Homo sapiens_hsa041450.30104621
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29896835
120Type II diabetes mellitus_Homo sapiens_hsa049300.29030288
121Sulfur relay system_Homo sapiens_hsa041220.27582379
122Type I diabetes mellitus_Homo sapiens_hsa049400.25146505
123Base excision repair_Homo sapiens_hsa034100.24432138
124Endocytosis_Homo sapiens_hsa041440.23923226

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