TYMP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.47088996
2L-phenylalanine catabolic process (GO:0006559)7.47088996
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.16713110
4L-phenylalanine metabolic process (GO:0006558)7.16713110
5aromatic amino acid family catabolic process (GO:0009074)6.74138162
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.55148025
7tryptophan catabolic process (GO:0006569)6.17489097
8indole-containing compound catabolic process (GO:0042436)6.17489097
9indolalkylamine catabolic process (GO:0046218)6.17489097
10kynurenine metabolic process (GO:0070189)6.09100325
11bile acid biosynthetic process (GO:0006699)5.99953934
12tryptophan metabolic process (GO:0006568)5.79969100
13glyoxylate metabolic process (GO:0046487)5.77966257
14alpha-linolenic acid metabolic process (GO:0036109)5.72390803
15urea metabolic process (GO:0019627)5.61095383
16urea cycle (GO:0000050)5.61095383
17high-density lipoprotein particle remodeling (GO:0034375)5.59631131
18negative regulation of fibrinolysis (GO:0051918)5.52873237
19cysteine metabolic process (GO:0006534)5.47499415
20sulfur amino acid catabolic process (GO:0000098)5.35606277
21regulation of fibrinolysis (GO:0051917)5.35542688
22peptidyl-glutamic acid carboxylation (GO:0017187)5.34240937
23protein carboxylation (GO:0018214)5.34240937
24regulation of protein activation cascade (GO:2000257)5.28584751
25complement activation, alternative pathway (GO:0006957)5.22207837
26nitrogen cycle metabolic process (GO:0071941)5.16640544
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.15335433
28serine family amino acid catabolic process (GO:0009071)5.15268423
29bile acid metabolic process (GO:0008206)5.12238755
30response to peptidoglycan (GO:0032494)5.00864904
31negative regulation of cell killing (GO:0031342)5.00464368
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.00464368
33regulation of cholesterol esterification (GO:0010872)4.95261414
34regulation of complement activation (GO:0030449)4.92257109
35aromatic amino acid family metabolic process (GO:0009072)4.91246629
36regulation of triglyceride catabolic process (GO:0010896)4.90809022
37reverse cholesterol transport (GO:0043691)4.88520857
38negative regulation of interleukin-12 production (GO:0032695)4.87230411
39neutrophil activation involved in immune response (GO:0002283)4.84109394
40positive regulation of gamma-delta T cell activation (GO:0046645)4.79548616
41macromolecular complex remodeling (GO:0034367)4.76994803
42plasma lipoprotein particle remodeling (GO:0034369)4.76994803
43protein-lipid complex remodeling (GO:0034368)4.76994803
44negative regulation of cholesterol transport (GO:0032375)4.72504365
45negative regulation of sterol transport (GO:0032372)4.72504365
46macrophage activation involved in immune response (GO:0002281)4.71386311
47phospholipid efflux (GO:0033700)4.68273642
48tyrosine metabolic process (GO:0006570)4.68026160
49positive regulation by symbiont of host defense response (GO:0052509)4.67789282
50modulation by symbiont of host defense response (GO:0052031)4.67789282
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.67789282
52modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.67789282
53positive regulation by organism of defense response of other organism involved in symbiotic interact4.67789282
54modulation by symbiont of host immune response (GO:0052553)4.67789282
55triglyceride homeostasis (GO:0070328)4.67688303
56acylglycerol homeostasis (GO:0055090)4.67688303
57amino-acid betaine metabolic process (GO:0006577)4.65765014
58homocysteine metabolic process (GO:0050667)4.64440331
59alpha-amino acid catabolic process (GO:1901606)4.61706212
60lysine catabolic process (GO:0006554)4.58208529
61lysine metabolic process (GO:0006553)4.58208529
62glycine metabolic process (GO:0006544)4.56138396
63detection of other organism (GO:0098543)4.54404887
64imidazole-containing compound metabolic process (GO:0052803)4.53607568
65antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.48419744
66cellular ketone body metabolic process (GO:0046950)4.48413130
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.46871305
68detection of bacterium (GO:0016045)4.46350419
69immunoglobulin mediated immune response (GO:0016064)4.45756901
70bile acid and bile salt transport (GO:0015721)4.45157783
71antigen processing and presentation of endogenous antigen (GO:0019883)4.44902965
72coenzyme catabolic process (GO:0009109)4.42176897
73indolalkylamine metabolic process (GO:0006586)4.36437027
74plasma lipoprotein particle clearance (GO:0034381)4.35246010
75cholesterol efflux (GO:0033344)4.28052499
76serine family amino acid metabolic process (GO:0009069)4.27370144
77glutamate metabolic process (GO:0006536)4.26847611
78amine catabolic process (GO:0009310)4.24322221
79cellular biogenic amine catabolic process (GO:0042402)4.24322221
80cellular amino acid catabolic process (GO:0009063)4.24024403
81ethanol oxidation (GO:0006069)4.23444428
82antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.21077082
83cellular glucuronidation (GO:0052695)4.20497720
84serine family amino acid biosynthetic process (GO:0009070)4.17440563
85benzene-containing compound metabolic process (GO:0042537)4.08676318
86plasma lipoprotein particle assembly (GO:0034377)4.08649807
87type I interferon signaling pathway (GO:0060337)4.07377605
88cellular response to type I interferon (GO:0071357)4.07377605
89response to type I interferon (GO:0034340)4.05542681
90cellular modified amino acid catabolic process (GO:0042219)4.05205176
91positive regulation of lipoprotein lipase activity (GO:0051006)4.03670949
92positive regulation of triglyceride lipase activity (GO:0061365)4.03670949
93low-density lipoprotein particle remodeling (GO:0034374)4.01010245
94arginine metabolic process (GO:0006525)3.96333448
95aldehyde catabolic process (GO:0046185)3.95427366
96dicarboxylic acid biosynthetic process (GO:0043650)3.93531953
97drug catabolic process (GO:0042737)3.92869109
98detection of external biotic stimulus (GO:0098581)3.91120279
99fibrinolysis (GO:0042730)3.89744777
100ketone body metabolic process (GO:1902224)3.87988189
101regulation of cholesterol homeostasis (GO:2000188)3.86812407
102very-low-density lipoprotein particle assembly (GO:0034379)3.82667336
103blood coagulation, intrinsic pathway (GO:0007597)3.82349936
104cholesterol homeostasis (GO:0042632)3.78118311
105complement activation, classical pathway (GO:0006958)3.77172076
106cofactor catabolic process (GO:0051187)3.77168931
107interferon-gamma-mediated signaling pathway (GO:0060333)3.74660124
108carboxylic acid catabolic process (GO:0046395)3.73447790
109organic acid catabolic process (GO:0016054)3.73447790
110positive regulation of lipid catabolic process (GO:0050996)3.72533695
111regulation of dendritic cell antigen processing and presentation (GO:0002604)3.71673641
112sterol homeostasis (GO:0055092)3.71314695
113intestinal cholesterol absorption (GO:0030299)3.69670400
114uronic acid metabolic process (GO:0006063)3.69450397
115glucuronate metabolic process (GO:0019585)3.69450397
116regulation of bile acid biosynthetic process (GO:0070857)3.69402501
117complement activation (GO:0006956)3.69315079
118detection of molecule of bacterial origin (GO:0032490)3.69313163
119protein activation cascade (GO:0072376)3.68278334
120protein-lipid complex assembly (GO:0065005)3.66809301
121cytolysis (GO:0019835)3.65481731
122regulation of interferon-beta biosynthetic process (GO:0045357)3.64335225
123plasma lipoprotein particle organization (GO:0071827)3.64139058
124phospholipid homeostasis (GO:0055091)3.63991114
125negative regulation of lipase activity (GO:0060192)3.62681411
126acetyl-CoA metabolic process (GO:0006084)3.62275720
127lipopolysaccharide-mediated signaling pathway (GO:0031663)3.60714058
128leukocyte aggregation (GO:0070486)3.60137964
129short-chain fatty acid metabolic process (GO:0046459)3.59559736
130opsonization (GO:0008228)3.57423461
131NIK/NF-kappaB signaling (GO:0038061)3.56237762
132germinal center formation (GO:0002467)3.52439200
133positive regulation of antigen processing and presentation (GO:0002579)3.48750499
134regulation of gamma-delta T cell activation (GO:0046643)3.47754380
135detection of biotic stimulus (GO:0009595)3.43683821
136regulation of antigen processing and presentation (GO:0002577)3.42760100
137regulation of mast cell degranulation (GO:0043304)3.41785535
138defense response to protozoan (GO:0042832)3.38068627
139macrophage activation (GO:0042116)3.33656374
140response to muramyl dipeptide (GO:0032495)3.33556509
141respiratory burst (GO:0045730)3.33316835
142granulocyte activation (GO:0036230)3.32418581
143B cell mediated immunity (GO:0019724)3.31054172
144myeloid cell activation involved in immune response (GO:0002275)3.29786126
145negative regulation of cytokine production involved in immune response (GO:0002719)3.29201308
146T-helper 1 type immune response (GO:0042088)3.29135225
147positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.28434622
148myeloid dendritic cell differentiation (GO:0043011)3.26968354
149cellular extravasation (GO:0045123)3.26783862
150regulation of T cell tolerance induction (GO:0002664)3.26668590
151negative regulation of erythrocyte differentiation (GO:0045647)3.26319568
152neutrophil activation (GO:0042119)3.22842904
153response to protozoan (GO:0001562)3.16852027
154regulation of myeloid leukocyte mediated immunity (GO:0002886)3.15785336
155response to host immune response (GO:0052572)3.15082787
156response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.15082787
157negative regulation of lymphocyte mediated immunity (GO:0002707)3.15045612
158regulation of tolerance induction (GO:0002643)3.12958825
159regulation of interferon-alpha production (GO:0032647)3.12223911
160regulation of mast cell activation involved in immune response (GO:0033006)3.12113933
161regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.12045801
162microglial cell activation (GO:0001774)3.09239794
163positive regulation of type 2 immune response (GO:0002830)3.06952296
164myeloid dendritic cell activation (GO:0001773)3.05728163
165regulation of leukocyte degranulation (GO:0043300)3.05292005
166positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.03982622
167positive regulation of interferon-alpha production (GO:0032727)3.03308067
168regulation of T-helper 2 cell differentiation (GO:0045628)3.00649329
169negative regulation of leukocyte mediated immunity (GO:0002704)3.00577810
170regulation of B cell receptor signaling pathway (GO:0050855)2.99822565
171positive regulation of mast cell activation (GO:0033005)2.98189767
172negative regulation of innate immune response (GO:0045824)2.97757910
173negative regulation of T cell mediated immunity (GO:0002710)2.97565918
174positive regulation of cellular amide metabolic process (GO:0034250)2.96612169
175cellular response to interferon-gamma (GO:0071346)2.94740822
176regulation of T-helper 1 cell differentiation (GO:0045625)2.91663540
177leukocyte migration involved in inflammatory response (GO:0002523)2.90160873
178response to host (GO:0075136)2.87788573
179response to host defenses (GO:0052200)2.87788573
180response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.87788573
181regulation of mast cell activation (GO:0033003)2.85097672
182response to interferon-gamma (GO:0034341)2.84804116
183positive regulation of mast cell activation involved in immune response (GO:0033008)2.84165377
184positive regulation of mast cell degranulation (GO:0043306)2.84165377
185hydrogen peroxide biosynthetic process (GO:0050665)2.82602728
186production of molecular mediator involved in inflammatory response (GO:0002532)2.77718826
187regulation of type 2 immune response (GO:0002828)2.77417718
188positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.75537548
189regulation of type I interferon-mediated signaling pathway (GO:0060338)2.71535011
190negative regulation of myeloid cell apoptotic process (GO:0033033)2.71256954
191cellular response to thyroid hormone stimulus (GO:0097067)2.71031306
192positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.68168532
193myeloid leukocyte activation (GO:0002274)2.67605202
194lymphocyte chemotaxis (GO:0048247)2.67449663
195positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.66264030
196amino sugar catabolic process (GO:0046348)2.66075283
197T cell migration (GO:0072678)2.65639361
198regulation of interleukin-12 production (GO:0032655)2.64968873
199negative regulation of production of molecular mediator of immune response (GO:0002701)2.63716627
200regulation of podosome assembly (GO:0071801)2.60828600

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.39386281
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.29162406
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.03349422
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.44861557
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.21678947
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.18060509
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.85125053
8IRF8_21731497_ChIP-ChIP_J774_Mouse4.21817258
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.12349493
10BP1_19119308_ChIP-ChIP_Hs578T_Human4.02248594
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.89040887
12IRF8_27001747_Chip-Seq_BMDM_Mouse3.06828555
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.03777397
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.89482485
15* VDR_21846776_ChIP-Seq_THP-1_Human2.89377841
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70074209
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.55950375
18VDR_24763502_ChIP-Seq_THP-1_Human2.55900382
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.46941151
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.21651433
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.18417045
22SPI1_23127762_ChIP-Seq_K562_Human2.10505324
23KDM2B_26808549_Chip-Seq_SUP-B15_Human2.10367957
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.08005150
25SPI1_23547873_ChIP-Seq_NB4_Human2.06812388
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04331965
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.02861683
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.01326431
29TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.01044665
30* MAF_26560356_Chip-Seq_TH1_Human2.00324892
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9815239
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.92845246
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.89900037
34MYC_22102868_ChIP-Seq_BL_Human1.80257275
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.79485844
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76375535
37TCF7_22412390_ChIP-Seq_EML_Mouse1.74006720
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72092989
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.71725451
40KDM2B_26808549_Chip-Seq_DND41_Human1.71387388
41UTX_26944678_Chip-Seq_JUKART_Human1.70824842
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69414875
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.69041049
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.65385857
45CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64285039
46SCL_19346495_ChIP-Seq_HPC-7_Human1.63042468
47RUNX_20019798_ChIP-Seq_JUKART_Human1.62094051
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60967015
49VDR_24787735_ChIP-Seq_THP-1_Human1.59897781
50MAF_26560356_Chip-Seq_TH2_Human1.59436587
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.49514697
52MYB_26560356_Chip-Seq_TH2_Human1.47645077
53HTT_18923047_ChIP-ChIP_STHdh_Human1.43699355
54PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42382016
55CLOCK_20551151_ChIP-Seq_293T_Human1.40388150
56HNF4A_19822575_ChIP-Seq_HepG2_Human1.40007582
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38567990
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.38510992
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38335010
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38008884
61GATA1_22025678_ChIP-Seq_K562_Human1.37444938
62PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33397429
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32679170
64MYB_26560356_Chip-Seq_TH1_Human1.31491251
65RXRA_24833708_ChIP-Seq_LIVER_Mouse1.30453891
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30076950
67SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29586477
68RACK7_27058665_Chip-Seq_MCF-7_Human1.28415463
69PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27931359
70TP63_17297297_ChIP-ChIP_HaCaT_Human1.27777248
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25982386
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24587784
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22105153
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21969950
75CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20410459
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19051281
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16304459
78PU_27001747_Chip-Seq_BMDM_Mouse1.16303931
79* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15327851
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15067680
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13971917
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13650946
83GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11103941
84PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10618593
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.09975854
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09285861
87SA1_27219007_Chip-Seq_ERYTHROID_Human1.09097725
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08295752
89P68_20966046_ChIP-Seq_HELA_Human1.06994160
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06355480
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03637892
92GATA3_27048872_Chip-Seq_THYMUS_Human1.03310529
93KDM2B_26808549_Chip-Seq_JURKAT_Human1.00977476
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00672254
95IRF8_22096565_ChIP-ChIP_GC-B_Human0.97985110
96SMAD_19615063_ChIP-ChIP_OVARY_Human0.96992945
97KDM2B_26808549_Chip-Seq_K562_Human0.96274770
98SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96017192
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95957223
100NCOR1_26117541_ChIP-Seq_K562_Human0.94711369
101GATA2_21666600_ChIP-Seq_HMVEC_Human0.94670312
102NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93725016
103STAT1_20625510_ChIP-Seq_HELA_Human0.93284567
104SMC4_20622854_ChIP-Seq_HELA_Human0.92825276
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.91433960
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91367782
107RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88617521
108ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88338482
109RARA_24833708_ChIP-Seq_LIVER_Mouse0.86131434
110KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83365045
111GATA4_25053715_ChIP-Seq_YYC3_Human0.83241405
112ZNF263_19887448_ChIP-Seq_K562_Human0.82811651
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82467457
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80221454
115AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78148025
116RARB_24833708_ChIP-Seq_LIVER_Mouse0.75755437
117TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.75513832
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.73733144
119PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.73241804
120STAT3_1855785_ChIP-Seq_MESCs_Mouse0.71093451
121CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70313848
122RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69806274
123LXR_22292898_ChIP-Seq_THP-1_Human0.68505073
124NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.67835834
125BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62704245
126CEBPB_22108803_ChIP-Seq_LS180_Human0.60103144
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.58608040
128RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.58350217
129AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.57878404
130ESR2_21235772_ChIP-Seq_MCF-7_Human0.55741835
131SALL4_18804426_ChIP-ChIP_XEN_Mouse0.55614827
132MYC_19915707_ChIP-ChIP_AK7_Human0.54797114
133P53_21459846_ChIP-Seq_SAOS-2_Human0.54339804
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53829085
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.53562447
136AR_20517297_ChIP-Seq_VCAP_Human0.53418379
137NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.51797881
138ESET_19884257_ChIP-Seq_ESCs_Mouse0.51613418
139STAT1_17558387_ChIP-Seq_HELA_Human0.50316722
140PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.49754018
141SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.49460316
142BCOR_27268052_Chip-Seq_Bcells_Human0.49315995
143GATA1_19941827_ChIP-Seq_MEL_Mouse0.47881518
144TAF2_19829295_ChIP-Seq_ESCs_Human0.46973580
145FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.46782967
146FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.46388293
147FOXA1_25552417_ChIP-Seq_VCAP_Human0.46366121
148EGR1_19032775_ChIP-ChIP_M12_Human0.45811822
149TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.45434550
150TET1_21451524_ChIP-Seq_MESCs_Mouse0.45406780
151CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.45314819
152PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44888291
153GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.44855724
154PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44731981
155CDX2_20551321_ChIP-Seq_CACO-2_Human0.44703404
156GATA6_25053715_ChIP-Seq_YYC3_Human0.44398655
157BCL6_27268052_Chip-Seq_Bcells_Human0.44084126
158SPI1_26923725_Chip-Seq_HPCs_Mouse0.43553834
159CBP_21632823_ChIP-Seq_H3396_Human0.42139189
160NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.41512391
161NRF2_20460467_ChIP-Seq_MEFs_Mouse0.41512391
162SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.41257338
163GATA1_19941826_ChIP-Seq_K562_Human0.41174864
164SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.41014417
165LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.40469081
166GATA2_19941826_ChIP-Seq_K562_Human0.39895567
167RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.39721486
168FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.39622701
169STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39422601
170E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.38974992
171MYC_27129775_Chip-Seq_CORNEA_Mouse0.38535459
172CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.38283936
173SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38189447
174ERG_20517297_ChIP-Seq_VCAP_Human0.38023014
175SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.37934419
176BRD4_27068464_Chip-Seq_AML-cells_Mouse0.37794878
177OCT4_20526341_ChIP-Seq_ESCs_Human0.36818702

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.44272057
2MP0005360_urolithiasis7.73642461
3MP0005085_abnormal_gallbladder_physiolo6.39019757
4MP0005365_abnormal_bile_salt6.17103543
5MP0008875_abnormal_xenobiotic_pharmacok5.10362411
6MP0003303_peritoneal_inflammation4.19045901
7MP0003252_abnormal_bile_duct3.99131428
8MP0010329_abnormal_lipoprotein_level3.65788575
9MP0009840_abnormal_foam_cell3.50198445
10* MP0003806_abnormal_nucleotide_metabolis3.48517126
11MP0001835_abnormal_antigen_presentation3.48505680
12MP0009785_altered_susceptibility_to3.21872849
13MP0005083_abnormal_biliary_tract3.02305942
14MP0005058_abnormal_lysosome_morphology2.98976600
15MP0002419_abnormal_innate_immunity2.97230658
16MP0002148_abnormal_hypersensitivity_rea2.97078526
17MP0001790_abnormal_immune_system2.95558029
18MP0005387_immune_system_phenotype2.95558029
19MP0005025_abnormal_response_to2.87913011
20MP0001666_abnormal_nutrient_absorption2.82612297
21MP0005671_abnormal_response_to2.78445794
22MP0003195_calcinosis2.75136260
23MP0005000_abnormal_immune_tolerance2.74993550
24MP0005332_abnormal_amino_acid2.72522038
25* MP0006082_CNS_inflammation2.71037272
26MP0000685_abnormal_immune_system2.58896222
27MP0004510_myositis2.48975181
28MP0001800_abnormal_humoral_immune2.48804124
29MP0003300_gastrointestinal_ulcer2.40176949
30MP0003191_abnormal_cellular_cholesterol2.38436226
31MP0002452_abnormal_antigen_presenting2.36449880
32MP0002723_abnormal_immune_serum2.35729661
33MP0003172_abnormal_lysosome_physiology2.23680577
34MP0001533_abnormal_skeleton_physiology2.22074888
35MP0000609_abnormal_liver_physiology2.21943407
36MP0002420_abnormal_adaptive_immunity2.12028951
37MP0002118_abnormal_lipid_homeostasis2.11786178
38MP0001819_abnormal_immune_cell2.11655729
39MP0004019_abnormal_vitamin_homeostasis2.06707741
40MP0010155_abnormal_intestine_physiology1.98159066
41MP0009278_abnormal_bone_marrow1.96475570
42MP0004947_skin_inflammation1.90793208
43MP0002138_abnormal_hepatobiliary_system1.84139079
44MP0002405_respiratory_system_inflammati1.81620256
45* MP0005319_abnormal_enzyme/_coenzyme1.81032251
46MP0003868_abnormal_feces_composition1.80836854
47MP0000343_altered_response_to1.71405428
48MP0001764_abnormal_homeostasis1.70869781
49MP0009697_abnormal_copulation1.67166914
50MP0002998_abnormal_bone_remodeling1.57916166
51MP0005310_abnormal_salivary_gland1.57167874
52MP0008260_abnormal_autophagy1.55291609
53MP0009333_abnormal_splenocyte_physiolog1.52891859
54MP0000716_abnormal_immune_system1.52557237
55* MP0005584_abnormal_enzyme/coenzyme_acti1.51274679
56MP0005451_abnormal_body_composition1.49786165
57MP0000858_altered_metastatic_potential1.49746634
58MP0003453_abnormal_keratinocyte_physiol1.41884341
59MP0005397_hematopoietic_system_phenotyp1.41025885
60MP0001545_abnormal_hematopoietic_system1.41025885
61MP0002398_abnormal_bone_marrow1.34201896
62MP0003448_altered_tumor_morphology1.32824870
63MP0003763_abnormal_thymus_physiology1.31193603
64MP0003656_abnormal_erythrocyte_physiolo1.30977124
65MP0003183_abnormal_peptide_metabolism1.28083992
66MP0003011_delayed_dark_adaptation1.27365027
67MP0003828_pulmonary_edema1.26305502
68MP0003186_abnormal_redox_activity1.24280513
69MP0009643_abnormal_urine_homeostasis1.23914680
70MP0000598_abnormal_liver_morphology1.20488284
71MP0003705_abnormal_hypodermis_morpholog1.17794880
72MP0002429_abnormal_blood_cell1.17697379
73MP0000465_gastrointestinal_hemorrhage1.17329743
74MP0005647_abnormal_sex_gland1.15643860
75MP0001873_stomach_inflammation1.14097459
76MP0008004_abnormal_stomach_pH1.13862446
77MP0000689_abnormal_spleen_morphology1.13217560
78MP0000604_amyloidosis1.12903552
79MP0002722_abnormal_immune_system1.07997032
80MP0009764_decreased_sensitivity_to1.07293895
81MP0005164_abnormal_response_to1.03049098
82MP0003866_abnormal_defecation1.02861291
83MP0002277_abnormal_respiratory_mucosa1.02818450
84MP0009763_increased_sensitivity_to1.02352130
85MP0002933_joint_inflammation0.99724328
86MP0005167_abnormal_blood-brain_barrier0.99235220
87MP0001851_eye_inflammation0.98407041
88MP0010368_abnormal_lymphatic_system0.98142127
89MP0002254_reproductive_system_inflammat0.97983788
90MP0005636_abnormal_mineral_homeostasis0.97601797
91MP0005390_skeleton_phenotype0.97397531
92MP0001663_abnormal_digestive_system0.95960322
93MP0008469_abnormal_protein_level0.94094816
94MP0009642_abnormal_blood_homeostasis0.90326509
95MP0006054_spinal_hemorrhage0.86121872
96MP0005084_abnormal_gallbladder_morpholo0.84660699
97MP0003091_abnormal_cell_migration0.80251983
98MP0009765_abnormal_xenobiotic_induced0.78718635
99MP0002078_abnormal_glucose_homeostasis0.77973105
100MP0003795_abnormal_bone_structure0.77197829
101* MP0006036_abnormal_mitochondrial_physio0.77053892
102* MP0005376_homeostasis/metabolism_phenot0.76792867
103MP0005408_hypopigmentation0.76474533
104MP0002971_abnormal_brown_adipose0.74079521
105MP0002876_abnormal_thyroid_physiology0.71527050
106MP0002332_abnormal_exercise_endurance0.71125214
107MP0005334_abnormal_fat_pad0.70403712
108MP0000703_abnormal_thymus_morphology0.69829332
109MP0005670_abnormal_white_adipose0.69584324
110MP0005220_abnormal_exocrine_pancreas0.69131145
111MP0004858_abnormal_nervous_system0.68158162
112MP0005076_abnormal_cell_differentiation0.67095951
113MP0003329_amyloid_beta_deposits0.65924877
114MP0005023_abnormal_wound_healing0.65558380
115MP0000920_abnormal_myelination0.64756457
116MP0000490_abnormal_crypts_of0.63801488
117MP0001661_extended_life_span0.63777424
118MP0009053_abnormal_anal_canal0.62815260
119MP0005535_abnormal_body_temperature0.62683748
120MP0003279_aneurysm0.62563804
121MP0001849_ear_inflammation0.61501702
122MP0001542_abnormal_bone_strength0.61184914
123MP0005464_abnormal_platelet_physiology0.60374164
124MP0005448_abnormal_energy_balance0.59757788
125MP0004130_abnormal_muscle_cell0.59212597
126* MP0005266_abnormal_metabolism0.59200225
127MP0000639_abnormal_adrenal_gland0.58885585
128MP0005381_digestive/alimentary_phenotyp0.58143020
129MP0005165_increased_susceptibility_to0.55597171
130MP0001756_abnormal_urination0.55345145
131MP0003045_fibrosis0.55075476
132MP0003690_abnormal_glial_cell0.53050230
133MP0003436_decreased_susceptibility_to0.52014019
134MP0002822_catalepsy0.51714057
135MP0003718_maternal_effect0.50049711
136MP0003638_abnormal_response/metabolism_0.47982851
137MP0004782_abnormal_surfactant_physiolog0.47568627
138MP0002136_abnormal_kidney_physiology0.46442323
139MP0005395_other_phenotype0.46191277
140MP0002928_abnormal_bile_duct0.46050244
141MP0008873_increased_physiological_sensi0.45617852
142MP0003724_increased_susceptibility_to0.44958388
143MP0008874_decreased_physiological_sensi0.44218812
144MP0005166_decreased_susceptibility_to0.43381697
145* MP0006035_abnormal_mitochondrial_morpho0.42305914
146MP0003953_abnormal_hormone_level0.41668654
147MP0009384_cardiac_valve_regurgitation0.40247858
148MP0003075_altered_response_to0.39481174
149MP0004381_abnormal_hair_follicle0.38527676
150MP0002132_abnormal_respiratory_system0.37534265
151MP0008872_abnormal_physiological_respon0.37205167
152MP0009115_abnormal_fat_cell0.34782391
153MP0001853_heart_inflammation0.34486460
154MP0000249_abnormal_blood_vessel0.33596247
155MP0002970_abnormal_white_adipose0.32772566
156MP0001845_abnormal_inflammatory_respons0.32748373
157MP0005666_abnormal_adipose_tissue0.32481839
158MP0002796_impaired_skin_barrier0.32355680
159MP0002837_dystrophic_cardiac_calcinosis0.32071251
160MP0001243_abnormal_dermal_layer0.31355317
161MP0009672_abnormal_birth_weight0.31326952
162MP0000230_abnormal_systemic_arterial0.31067279
163MP0005248_abnormal_Harderian_gland0.30817529
164MP0004264_abnormal_extraembryonic_tissu0.27098899
165MP0001881_abnormal_mammary_gland0.26993619
166MP0000579_abnormal_nail_morphology0.24768477
167MP0004883_abnormal_blood_vessel0.24141023
168MP0002168_other_aberrant_phenotype0.23851437
169MP0002135_abnormal_kidney_morphology0.23778513
170MP0004147_increased_porphyrin_level0.23315578
171MP0000427_abnormal_hair_cycle0.22851088

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.33988233
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.28736983
3Deep venous thrombosis (HP:0002625)7.24165455
4Hypobetalipoproteinemia (HP:0003563)6.66126339
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.60724928
6Prolonged partial thromboplastin time (HP:0003645)6.49037470
7Xanthomatosis (HP:0000991)6.27291077
8Eczematoid dermatitis (HP:0000976)5.98550352
9Hyperlipoproteinemia (HP:0010980)5.51245686
10Abnormality of macrophages (HP:0004311)5.50918742
11Recurrent bacterial skin infections (HP:0005406)5.37814873
12Recurrent abscess formation (HP:0002722)5.27267448
13Complement deficiency (HP:0004431)5.21363996
14Abnormality of liposaccharide metabolism (HP:0010968)4.92953094
15Abnormality of glycosphingolipid metabolism (HP:0004343)4.92953094
16Abnormality of glycolipid metabolism (HP:0010969)4.92953094
17Hypolipoproteinemia (HP:0010981)4.83799970
18Myositis (HP:0100614)4.79302759
19Joint hemorrhage (HP:0005261)4.67801973
20Orchitis (HP:0100796)4.60269550
21Hyperammonemia (HP:0001987)4.58372213
22Hyperglycinemia (HP:0002154)4.52637516
23Abnormality of the common coagulation pathway (HP:0010990)4.41362654
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.39559405
25Epidermoid cyst (HP:0200040)4.39245388
26Retrobulbar optic neuritis (HP:0100654)4.29826018
27Optic neuritis (HP:0100653)4.29826018
28Fat malabsorption (HP:0002630)4.25140310
29Abnormality of sulfur amino acid metabolism (HP:0004339)4.22264872
30Ketosis (HP:0001946)4.19949048
31Abnormality of glutamine family amino acid metabolism (HP:0010902)4.13052469
32Hypoalphalipoproteinemia (HP:0003233)4.06592774
33Abnormality of methionine metabolism (HP:0010901)4.06031392
34Hyperglycinuria (HP:0003108)4.01011584
35Mediastinal lymphadenopathy (HP:0100721)3.99835711
36Abnormality of glycine metabolism (HP:0010895)3.99668115
37Abnormality of serine family amino acid metabolism (HP:0010894)3.99668115
38Abnormality of aspartate family amino acid metabolism (HP:0010899)3.99502987
39Increased cerebral lipofuscin (HP:0011813)3.87656764
40Hypoglycemic coma (HP:0001325)3.86883969
41Conjugated hyperbilirubinemia (HP:0002908)3.84959732
42Stomatitis (HP:0010280)3.81575096
43Abnormality of complement system (HP:0005339)3.80987822
44Abnormality of the intrinsic pathway (HP:0010989)3.80072293
45Abnormality of pyrimidine metabolism (HP:0004353)3.76502473
46Hypercholesterolemia (HP:0003124)3.69055817
47Loss of speech (HP:0002371)3.62604598
48Elevated erythrocyte sedimentation rate (HP:0003565)3.59662617
49Chronic obstructive pulmonary disease (HP:0006510)3.55984812
50Obstructive lung disease (HP:0006536)3.55984812
51Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.50740952
52Dysostosis multiplex (HP:0000943)3.46163699
53Abnormality of fatty-acid metabolism (HP:0004359)3.41849108
54Recurrent fungal infections (HP:0002841)3.41094508
55Hyperbilirubinemia (HP:0002904)3.40735879
56Recurrent skin infections (HP:0001581)3.40661481
57Increased IgE level (HP:0003212)3.20339950
58Gastrointestinal infarctions (HP:0005244)3.19947792
59Gingivitis (HP:0000230)3.18911284
60Increased neuronal autofluorescent lipopigment (HP:0002074)3.17742867
61Steatorrhea (HP:0002570)3.15313929
62Meningitis (HP:0001287)3.15255380
63Delayed CNS myelination (HP:0002188)3.13911325
64Spontaneous abortion (HP:0005268)3.13108851
65Abnormality of nucleobase metabolism (HP:0010932)3.07356361
66Vacuolated lymphocytes (HP:0001922)3.06457840
67Abnormality of serum amino acid levels (HP:0003112)3.05489949
68Keratoconjunctivitis sicca (HP:0001097)3.03127116
69Vasculitis (HP:0002633)3.02884315
70Disinhibition (HP:0000734)3.01927166
71Ketoacidosis (HP:0001993)2.99259769
72Myocardial infarction (HP:0001658)2.96942428
73Spontaneous hematomas (HP:0007420)2.89682940
74Hemoptysis (HP:0002105)2.88597833
75Hepatocellular carcinoma (HP:0001402)2.87862653
76Pulmonary infiltrates (HP:0002113)2.86507451
77Chronic mucocutaneous candidiasis (HP:0002728)2.83841707
78Recurrent cutaneous fungal infections (HP:0011370)2.83841707
79Hypochromic microcytic anemia (HP:0004840)2.83251606
80Metabolic acidosis (HP:0001942)2.83149806
81Purpura (HP:0000979)2.80559493
82Increased serum ferritin (HP:0003281)2.79975808
83Urticaria (HP:0001025)2.79527383
84Keratoconjunctivitis (HP:0001096)2.78244990
85Abnormality of polysaccharide metabolism (HP:0011012)2.75476014
86Abnormality of glycosaminoglycan metabolism (HP:0004371)2.75476014
87Abnormality of mucopolysaccharide metabolism (HP:0011020)2.75476014
88Acanthocytosis (HP:0001927)2.74709298
89Abnormality of purine metabolism (HP:0004352)2.72783305
90Systemic lupus erythematosus (HP:0002725)2.68421459
91Autoimmune thrombocytopenia (HP:0001973)2.67944923
92Encephalitis (HP:0002383)2.67692048
93Abnormality of dicarboxylic acid metabolism (HP:0010995)2.67238778
94Dicarboxylic aciduria (HP:0003215)2.67238778
95Skin nodule (HP:0200036)2.67082324
96Abnormal delayed hypersensitivity skin test (HP:0002963)2.62760367
97Recurrent viral infections (HP:0004429)2.61916052
98Abnormality of the nasal mucosa (HP:0000433)2.60775658
99Vascular calcification (HP:0004934)2.60444729
100Lethargy (HP:0001254)2.59494119
101Cellulitis (HP:0100658)2.58529600
102Urinary glycosaminoglycan excretion (HP:0003541)2.58228115
103Mucopolysacchariduria (HP:0008155)2.58228115
104Petechiae (HP:0000967)2.57853010
105Colitis (HP:0002583)2.57554905
106Abnormal gallbladder physiology (HP:0012438)2.50235744
107Cholecystitis (HP:0001082)2.50235744
108Abnormal gallbladder morphology (HP:0012437)2.48103885
109Hypoglycemic seizures (HP:0002173)2.47164208
110Cholelithiasis (HP:0001081)2.45168404
111Increased IgM level (HP:0003496)2.44525269
112Gout (HP:0001997)2.42750826
113Spastic diplegia (HP:0001264)2.41960725
114Axonal loss (HP:0003447)2.40990782
115Inflammation of the large intestine (HP:0002037)2.40513712
116Mutism (HP:0002300)2.40074725
117Nasal polyposis (HP:0100582)2.38501291
118Pustule (HP:0200039)2.35281048
119Mitral stenosis (HP:0001718)2.35179302
120Glomerulonephritis (HP:0000099)2.33500910
121Neonatal onset (HP:0003623)2.32910095
122Cerebral edema (HP:0002181)2.32395127
123Gastrointestinal inflammation (HP:0004386)2.31493098
124Premature loss of primary teeth (HP:0006323)2.30802375
125Cardiovascular calcification (HP:0011915)2.30247993
126Irritability (HP:0000737)2.28454516
127Late onset (HP:0003584)2.27255076
128Brushfield spots (HP:0001088)2.27074500
129Interstitial pulmonary disease (HP:0006530)2.26563144
130Hypergammaglobulinemia (HP:0010702)2.26301307
131Hepatosplenomegaly (HP:0001433)2.25542539
132Chest pain (HP:0100749)2.25255719
133Gangrene (HP:0100758)2.24278174
134Amyloidosis (HP:0011034)2.24179658
135Recurrent gram-negative bacterial infections (HP:0005420)2.22075166
136Sensorimotor neuropathy (HP:0007141)2.21849188
137Gingival bleeding (HP:0000225)2.20879773
138Anorexia (HP:0002039)2.19952676
139Poikilocytosis (HP:0004447)2.19791308
140Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.19024354
141Pulmonary embolism (HP:0002204)2.18346898
142Episodic fever (HP:0001954)2.18127725
143Neuronal loss in central nervous system (HP:0002529)2.17964179
144Arterial thrombosis (HP:0004420)2.16768865
145Pancreatitis (HP:0001733)2.15789625
146Hematochezia (HP:0002573)2.15777617
147Opisthotonus (HP:0002179)2.15102061
148Hemorrhage of the eye (HP:0011885)2.15031005
149Neurofibrillary tangles (HP:0002185)2.14954978
150Prolonged bleeding time (HP:0003010)2.14335572
151Esophageal varix (HP:0002040)2.12744518
152Epistaxis (HP:0000421)2.12597368
153Thrombophlebitis (HP:0004418)2.12571538
154Leukocytosis (HP:0001974)2.12232632
155Menorrhagia (HP:0000132)2.10306320
156Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.09878868
157Osteomyelitis (HP:0002754)2.08603806
158Gastrointestinal stroma tumor (HP:0100723)2.06678375
159T lymphocytopenia (HP:0005403)2.06013911
160Generalized aminoaciduria (HP:0002909)2.05455231
161Enlarged kidneys (HP:0000105)2.03169414
162Abnormality of the gallbladder (HP:0005264)2.03143422
163Abnormality of the pleura (HP:0002103)2.01320178
164Progressive neurologic deterioration (HP:0002344)2.00811029
165Chronic otitis media (HP:0000389)2.00191959
166Nuclear cataract (HP:0100018)2.00063301
167* Vomiting (HP:0002013)1.99796537
168Hyperinsulinemic hypoglycemia (HP:0000825)1.99573564
169Abnormality of proline metabolism (HP:0010907)1.99219282
170Hydroxyprolinuria (HP:0003080)1.99219282
171Restrictive lung disease (HP:0002091)1.98727455
172Abnormality of iron homeostasis (HP:0011031)1.97826856
173Abnormality of T cell number (HP:0011839)1.97560127
174Abnormality of transition element cation homeostasis (HP:0011030)1.96930423
175Polyneuropathy (HP:0001271)1.96180073
176Acne (HP:0001061)1.93243110
177Elevated hepatic transaminases (HP:0002910)1.89079235
178Upper motor neuron abnormality (HP:0002127)1.88874866
179Thin bony cortex (HP:0002753)1.88461912
180Reticulocytosis (HP:0001923)1.87523980
181Recurrent pneumonia (HP:0006532)1.86238398
182Rickets (HP:0002748)1.84225005
183Abnormal cartilage morphology (HP:0002763)1.84185755
184Renal cortical cysts (HP:0000803)1.80689200
185Abnormal enzyme/coenzyme activity (HP:0012379)1.76487475
186Abnormality of vitamin metabolism (HP:0100508)1.75492324
187Status epilepticus (HP:0002133)1.74784881
188Glycosuria (HP:0003076)1.70367557
189Abnormality of urine glucose concentration (HP:0011016)1.70367557
190Hypophosphatemic rickets (HP:0004912)1.69147357
191Nephritis (HP:0000123)1.67738994

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.14007156
2ERN14.93568178
3FGFR44.61663516
4SIK14.60642009
5RIPK43.85633509
6BLK3.41501123
7TAOK33.26087158
8IRAK42.60523275
9ERBB42.57783625
10INSRR2.55950120
11FLT32.17822520
12PRPF4B2.16173958
13PKN22.11138757
14TAOK12.05479658
15MAP2K42.04583509
16MST1R2.01764659
17PIK3CG2.00249683
18FGR1.98687139
19TRIB31.92956893
20TYK21.92399198
21MAPK111.83754696
22TNK21.82623833
23NME21.81059707
24KDR1.76497037
25FES1.71519119
26MATK1.69823366
27PTK61.58325308
28GRK71.57758423
29FRK1.56120200
30IKBKB1.49755998
31MAP3K101.44541528
32CDC42BPA1.41150431
33ABL21.39240875
34DAPK21.37004325
35SYK1.34712518
36LATS11.33834494
37TXK1.31509054
38GRK61.29501556
39MAP3K71.25484688
40LYN1.25360880
41HCK1.24152579
42MAP2K31.23462489
43TBK11.22311739
44SIK31.22275562
45DDR21.18422011
46JAK21.17178965
47NEK91.12903590
48MAPK151.10988317
49PINK11.06845842
50PRKAA21.03256473
51MAP3K111.02314718
52LCK1.00489555
53MAPK40.95955502
54DYRK1B0.95428131
55FGFR20.92937480
56JAK10.91535042
57ERBB20.91168138
58IRAK30.87331604
59PRKD20.85574624
60CDK60.84917382
61MARK20.84465692
62PRKCZ0.84057537
63MARK30.83940872
64MAP2K60.83739435
65PDK40.82185421
66PDK30.82185421
67MAP3K30.80664595
68MAP3K140.80543120
69SIK20.78875875
70IRAK20.75496379
71EPHA30.75393141
72STK38L0.74277114
73MAPK120.71077243
74BMPR20.70984930
75TIE10.70675818
76ICK0.70529836
77CHUK0.70029217
78MOS0.69124278
79EPHB10.67560700
80PRKACG0.67558945
81CSF1R0.66045695
82TGFBR20.63565074
83PRKAA10.62959532
84CAMK2G0.62796790
85CSK0.61975356
86MET0.59645167
87STK100.59495453
88SMG10.59249755
89HIPK20.59022959
90MAP4K10.58078435
91CDK40.57852477
92RPS6KC10.57759217
93RPS6KL10.57759217
94RIPK10.57516911
95ACVR1B0.56996502
96GSK3A0.54923419
97BMX0.52378859
98IKBKE0.51944151
99CAMK1D0.51821835
100KSR20.51649964
101FYN0.51429659
102MAPK70.49752213
103RPS6KA60.47375333
104PIM20.46802965
105PRKCQ0.45759913
106TESK10.45719346
107PDPK10.45359683
108PTK20.45049223
109MAP3K50.42793519
110YES10.41712596
111ZAP700.41121166
112TESK20.40961914
113RPS6KA20.40949635
114KIT0.39618864
115TAOK20.39572370
116GRK10.39169559
117TEC0.39138755
118MTOR0.38745846
119CSNK1G10.38724665
120MAP3K130.38014961
121CAMKK20.36877618
122IGF1R0.36280754
123ADRBK20.35826622
124MAPKAPK20.35172773
125FGFR30.34314646
126LRRK20.33912130
127MAP2K10.32659175
128PDK10.31561003
129SGK30.31517119
130MAP2K20.30803879
131MAP3K60.30616470
132PRKCG0.30487654
133MAP3K10.30261819
134PRKCD0.29920612
135ABL10.29879306
136PDK20.29100491
137PIM10.28580767
138PAK40.27714196
139BTK0.27020624
140AKT30.24948997
141EGFR0.24795512
142IRAK10.23302299
143CAMK40.23071982
144PRKCA0.22350642
145ITK0.21186922
146CSNK1G30.20839439
147RET0.18910707
148JAK30.16597037
149CSNK1G20.16508432
150MAPK30.15872719
151PRKG20.15010222

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.54609265
2Nitrogen metabolism_Homo sapiens_hsa009103.36041810
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33771253
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.16465490
5Arginine biosynthesis_Homo sapiens_hsa002202.94745048
6Osteoclast differentiation_Homo sapiens_hsa043802.94647119
7Leishmaniasis_Homo sapiens_hsa051402.88902004
8Allograft rejection_Homo sapiens_hsa053302.70825522
9Complement and coagulation cascades_Homo sapiens_hsa046102.70764157
10Other glycan degradation_Homo sapiens_hsa005112.70642379
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.69815676
12Tryptophan metabolism_Homo sapiens_hsa003802.69786577
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.67772653
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54384481
15Fatty acid degradation_Homo sapiens_hsa000712.53660618
16Graft-versus-host disease_Homo sapiens_hsa053322.49969482
17Autoimmune thyroid disease_Homo sapiens_hsa053202.38261841
18Toll-like receptor signaling pathway_Homo sapiens_hsa046202.37880456
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36043619
20Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24256516
21Tuberculosis_Homo sapiens_hsa051522.20243742
22Asthma_Homo sapiens_hsa053102.18427472
23Butanoate metabolism_Homo sapiens_hsa006502.11208764
24Peroxisome_Homo sapiens_hsa041462.10715726
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10595976
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.08561863
27Lysosome_Homo sapiens_hsa041422.00215690
28Rheumatoid arthritis_Homo sapiens_hsa053231.99834704
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.99316503
30Histidine metabolism_Homo sapiens_hsa003401.96385954
31Malaria_Homo sapiens_hsa051441.95303823
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.94181941
33Chemical carcinogenesis_Homo sapiens_hsa052041.93893837
34Propanoate metabolism_Homo sapiens_hsa006401.92256122
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.91095587
36Type I diabetes mellitus_Homo sapiens_hsa049401.90353986
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.89798919
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.89070980
39PPAR signaling pathway_Homo sapiens_hsa033201.87963446
40Caffeine metabolism_Homo sapiens_hsa002321.82614495
41Pertussis_Homo sapiens_hsa051331.81092371
42Antigen processing and presentation_Homo sapiens_hsa046121.80842792
43Fatty acid metabolism_Homo sapiens_hsa012121.80668719
44Retinol metabolism_Homo sapiens_hsa008301.74729551
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.74104031
46beta-Alanine metabolism_Homo sapiens_hsa004101.71695921
47Staphylococcus aureus infection_Homo sapiens_hsa051501.70811832
48TNF signaling pathway_Homo sapiens_hsa046681.69382981
49B cell receptor signaling pathway_Homo sapiens_hsa046621.67639697
50Selenocompound metabolism_Homo sapiens_hsa004501.67514548
51* Drug metabolism - other enzymes_Homo sapiens_hsa009831.67453627
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.66654813
53Influenza A_Homo sapiens_hsa051641.63813794
54Toxoplasmosis_Homo sapiens_hsa051451.63699680
55Legionellosis_Homo sapiens_hsa051341.60906219
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56332147
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54620664
58Phagosome_Homo sapiens_hsa041451.54391096
59Bile secretion_Homo sapiens_hsa049761.53687615
60Hematopoietic cell lineage_Homo sapiens_hsa046401.53180233
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49990086
62Primary immunodeficiency_Homo sapiens_hsa053401.49868337
63Viral myocarditis_Homo sapiens_hsa054161.49790290
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49481691
65Phenylalanine metabolism_Homo sapiens_hsa003601.49292058
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46643985
67Tyrosine metabolism_Homo sapiens_hsa003501.43537602
68Pyruvate metabolism_Homo sapiens_hsa006201.41721723
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.41467244
70Measles_Homo sapiens_hsa051621.41442937
71Folate biosynthesis_Homo sapiens_hsa007901.39058383
72Chemokine signaling pathway_Homo sapiens_hsa040621.38797484
73Herpes simplex infection_Homo sapiens_hsa051681.37181573
74Cysteine and methionine metabolism_Homo sapiens_hsa002701.36831791
75Sulfur metabolism_Homo sapiens_hsa009201.35655191
76Salmonella infection_Homo sapiens_hsa051321.34562670
77Fat digestion and absorption_Homo sapiens_hsa049751.34253835
78Fatty acid elongation_Homo sapiens_hsa000621.32788489
79Starch and sucrose metabolism_Homo sapiens_hsa005001.31886430
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26170518
81Acute myeloid leukemia_Homo sapiens_hsa052211.24291492
82ABC transporters_Homo sapiens_hsa020101.24199187
83Biosynthesis of amino acids_Homo sapiens_hsa012301.22110730
84Carbon metabolism_Homo sapiens_hsa012001.17075716
85Vitamin B6 metabolism_Homo sapiens_hsa007501.12433151
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11689425
87Jak-STAT signaling pathway_Homo sapiens_hsa046301.11139263
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09354385
89Sulfur relay system_Homo sapiens_hsa041221.08796937
90Steroid biosynthesis_Homo sapiens_hsa001001.07446534
91Cyanoamino acid metabolism_Homo sapiens_hsa004601.06644740
92Maturity onset diabetes of the young_Homo sapiens_hsa049501.03722065
93T cell receptor signaling pathway_Homo sapiens_hsa046601.01051118
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00835199
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99775746
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97404150
97Arginine and proline metabolism_Homo sapiens_hsa003300.97095059
98Vitamin digestion and absorption_Homo sapiens_hsa049770.96088763
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94448883
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94395648
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93859650
102Hepatitis B_Homo sapiens_hsa051610.93186748
103Shigellosis_Homo sapiens_hsa051310.90423378
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89054313
105One carbon pool by folate_Homo sapiens_hsa006700.86795448
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.85430402
107Apoptosis_Homo sapiens_hsa042100.84596162
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79102030
109Lysine degradation_Homo sapiens_hsa003100.78994260
110Amoebiasis_Homo sapiens_hsa051460.77902373
111VEGF signaling pathway_Homo sapiens_hsa043700.74424063
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74016766
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71548608
114Glycerolipid metabolism_Homo sapiens_hsa005610.69957224
115Glutathione metabolism_Homo sapiens_hsa004800.66614997
116Collecting duct acid secretion_Homo sapiens_hsa049660.66585114
117Pentose phosphate pathway_Homo sapiens_hsa000300.64713976
118Notch signaling pathway_Homo sapiens_hsa043300.64456968
119Prolactin signaling pathway_Homo sapiens_hsa049170.63299802
120Epstein-Barr virus infection_Homo sapiens_hsa051690.63089429
121Platelet activation_Homo sapiens_hsa046110.62618959
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59505383
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.56213913
124Endocytosis_Homo sapiens_hsa041440.55286392
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.53699011
126Fatty acid biosynthesis_Homo sapiens_hsa000610.53585900
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51196268
128Pancreatic cancer_Homo sapiens_hsa052120.49970293
129* Metabolic pathways_Homo sapiens_hsa011000.48753739
130Chronic myeloid leukemia_Homo sapiens_hsa052200.46775804
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44224452
132HTLV-I infection_Homo sapiens_hsa051660.43580334
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.42245938
134GnRH signaling pathway_Homo sapiens_hsa049120.41909875
135Sphingolipid metabolism_Homo sapiens_hsa006000.41897712
136Galactose metabolism_Homo sapiens_hsa000520.40429674
137* Bladder cancer_Homo sapiens_hsa052190.35738561
138Non-small cell lung cancer_Homo sapiens_hsa052230.35687140
139Viral carcinogenesis_Homo sapiens_hsa052030.34121756
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33083456
141Type II diabetes mellitus_Homo sapiens_hsa049300.31724944
142Renal cell carcinoma_Homo sapiens_hsa052110.31594011
143HIF-1 signaling pathway_Homo sapiens_hsa040660.31464760
144Fructose and mannose metabolism_Homo sapiens_hsa000510.31151443
145Prion diseases_Homo sapiens_hsa050200.31147086
146alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29506746
147MAPK signaling pathway_Homo sapiens_hsa040100.24634717
148Linoleic acid metabolism_Homo sapiens_hsa005910.24026894
149FoxO signaling pathway_Homo sapiens_hsa040680.22912370
150Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22827523
151Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22643432
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.22287249
153Insulin resistance_Homo sapiens_hsa049310.22117361
154Vibrio cholerae infection_Homo sapiens_hsa051100.21725723
155Dorso-ventral axis formation_Homo sapiens_hsa043200.20226335
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.19649997
157Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12626313
158Glucagon signaling pathway_Homo sapiens_hsa049220.10090688
159Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2445218
160Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2436206
161RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.2365736
162Mineral absorption_Homo sapiens_hsa04978-0.2199705
163Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2034648
164Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1946542
165Hepatitis C_Homo sapiens_hsa05160-0.1908536
166African trypanosomiasis_Homo sapiens_hsa05143-0.1715108
167Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1535141
168Regulation of autophagy_Homo sapiens_hsa04140-0.1445515
169Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1400866
170Insulin signaling pathway_Homo sapiens_hsa04910-0.1278204
171Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1266226
172Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1166797
173Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1093211
174Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0976771
175Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0963904
176Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0811460
177Renin-angiotensin system_Homo sapiens_hsa04614-0.0619526
178Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0318141
179Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0055639
180AMPK signaling pathway_Homo sapiens_hsa04152-0.0035217

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »