TYMS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.46085884
2telomere maintenance via semi-conservative replication (GO:0032201)5.43409125
3DNA strand elongation (GO:0022616)5.24792233
4DNA replication initiation (GO:0006270)5.18366296
5telomere maintenance via recombination (GO:0000722)4.95002254
6CENP-A containing nucleosome assembly (GO:0034080)4.93868069
7kinetochore organization (GO:0051383)4.89745158
8chromatin remodeling at centromere (GO:0031055)4.85622775
9DNA replication checkpoint (GO:0000076)4.79877340
10mitotic recombination (GO:0006312)4.79561878
11protein localization to kinetochore (GO:0034501)4.58106459
12DNA unwinding involved in DNA replication (GO:0006268)4.56490433
13mitotic metaphase plate congression (GO:0007080)4.52717972
14kinetochore assembly (GO:0051382)4.48075340
15telomere maintenance via telomere lengthening (GO:0010833)4.37417461
16DNA replication-independent nucleosome organization (GO:0034724)4.34445895
17DNA replication-independent nucleosome assembly (GO:0006336)4.34445895
18nucleotide-excision repair, DNA gap filling (GO:0006297)4.27418389
19ribosomal small subunit assembly (GO:0000028)4.04439631
20* regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.01422323
21negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.96165207
22metaphase plate congression (GO:0051310)3.96004852
23meiotic chromosome segregation (GO:0045132)3.92906352
24histone exchange (GO:0043486)3.92257674
25protein localization to chromosome, centromeric region (GO:0071459)3.89098988
26DNA replication-dependent nucleosome assembly (GO:0006335)3.89065669
27DNA replication-dependent nucleosome organization (GO:0034723)3.89065669
28chromosome condensation (GO:0030261)3.88955650
29nucleobase biosynthetic process (GO:0046112)3.83425099
30regulation of double-strand break repair via homologous recombination (GO:0010569)3.81198876
31attachment of spindle microtubules to kinetochore (GO:0008608)3.73402867
32DNA deamination (GO:0045006)3.72701924
33folic acid-containing compound biosynthetic process (GO:0009396)3.67215537
34heterochromatin organization (GO:0070828)3.66652370
35mitotic chromosome condensation (GO:0007076)3.62816888
36purine nucleobase biosynthetic process (GO:0009113)3.62114901
37establishment of chromosome localization (GO:0051303)3.61206194
38nucleobase-containing small molecule interconversion (GO:0015949)3.59967719
39regulation of nuclear cell cycle DNA replication (GO:0033262)3.59470052
40negative regulation of mRNA processing (GO:0050686)3.56342764
41mitotic sister chromatid cohesion (GO:0007064)3.54826178
42maturation of SSU-rRNA (GO:0030490)3.53977983
43protein K6-linked ubiquitination (GO:0085020)3.49821148
44mitotic sister chromatid segregation (GO:0000070)3.49523784
45telomere maintenance (GO:0000723)3.47423729
46telomere organization (GO:0032200)3.45817779
47DNA packaging (GO:0006323)3.44264337
48base-excision repair (GO:0006284)3.44198454
49IMP biosynthetic process (GO:0006188)3.41824439
50establishment of viral latency (GO:0019043)3.41254551
51mismatch repair (GO:0006298)3.40545405
52translesion synthesis (GO:0019985)3.37167970
53maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.36549133
54regulation of sister chromatid cohesion (GO:0007063)3.36261738
55nuclear pore organization (GO:0006999)3.32809278
56positive regulation of chromosome segregation (GO:0051984)3.32717498
57mitotic nuclear envelope disassembly (GO:0007077)3.29648583
58negative regulation of RNA splicing (GO:0033119)3.28917488
59protein localization to chromosome (GO:0034502)3.28851790
60transcription-coupled nucleotide-excision repair (GO:0006283)3.28827724
61DNA conformation change (GO:0071103)3.27475178
62regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.25025012
63sister chromatid segregation (GO:0000819)3.24884592
64DNA ligation (GO:0006266)3.24460446
65proteasome assembly (GO:0043248)3.24087373
66spindle checkpoint (GO:0031577)3.23994134
67ribosomal large subunit biogenesis (GO:0042273)3.22777618
68somatic diversification of immune receptors via somatic mutation (GO:0002566)3.19344510
69somatic hypermutation of immunoglobulin genes (GO:0016446)3.19344510
70regulation of mitotic spindle organization (GO:0060236)3.16639958
71viral transcription (GO:0019083)3.14463662
72* deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.11167234
73chromatin assembly or disassembly (GO:0006333)3.10672414
74rRNA modification (GO:0000154)3.10540910
75negative regulation of DNA-dependent DNA replication (GO:2000104)3.10184842
76viral mRNA export from host cell nucleus (GO:0046784)3.10016324
77regulation of centrosome cycle (GO:0046605)3.09264291
78regulation of mitochondrial translation (GO:0070129)3.09025869
79DNA replication (GO:0006260)3.08028577
80ATP-dependent chromatin remodeling (GO:0043044)3.06459536
81negative regulation of mRNA metabolic process (GO:1903312)3.05942173
82translational termination (GO:0006415)3.05822325
83* cell cycle G1/S phase transition (GO:0044843)3.05486750
84* G1/S transition of mitotic cell cycle (GO:0000082)3.05486750
85spliceosomal snRNP assembly (GO:0000387)3.05460062
86nuclear pore complex assembly (GO:0051292)3.05204048
87negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.04190127
88negative regulation of sister chromatid segregation (GO:0033046)3.04190127
89negative regulation of mitotic sister chromatid separation (GO:2000816)3.04190127
90negative regulation of mitotic sister chromatid segregation (GO:0033048)3.04190127
91establishment of integrated proviral latency (GO:0075713)3.03999340
92spindle assembly checkpoint (GO:0071173)3.03722533
93V(D)J recombination (GO:0033151)3.03578185
94DNA topological change (GO:0006265)3.03558053
95negative regulation of chromosome segregation (GO:0051985)3.03311323
96termination of RNA polymerase II transcription (GO:0006369)3.01849485
97ribosomal small subunit biogenesis (GO:0042274)3.01829898
98ribonucleoprotein complex biogenesis (GO:0022613)3.01673668
99regulation of spindle organization (GO:0090224)3.01510690
100regulation of translational fidelity (GO:0006450)3.01407565
101folic acid metabolic process (GO:0046655)3.01046789
102double-strand break repair via nonhomologous end joining (GO:0006303)2.99796166
103non-recombinational repair (GO:0000726)2.99796166
104DNA synthesis involved in DNA repair (GO:0000731)2.99420253
105chromosome segregation (GO:0007059)2.98947118
106regulation of mitotic metaphase/anaphase transition (GO:0030071)2.98485999
107formation of translation preinitiation complex (GO:0001731)2.98260726
108* deoxyribonucleotide biosynthetic process (GO:0009263)2.98091334
109regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.96853491
110nuclear envelope disassembly (GO:0051081)2.96568655
111membrane disassembly (GO:0030397)2.96568655
112ribosome biogenesis (GO:0042254)2.96240362
113chromatin assembly (GO:0031497)2.96080935
114anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.95875081
115negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.94747101
116DNA geometric change (GO:0032392)2.93926832
117mitotic spindle assembly checkpoint (GO:0007094)2.93503156
118DNA duplex unwinding (GO:0032508)2.93089396
119DNA strand renaturation (GO:0000733)2.92332844
120DNA catabolic process, exonucleolytic (GO:0000738)2.91418003
121regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.91318755
122DNA double-strand break processing (GO:0000729)2.90017940
123rRNA processing (GO:0006364)2.89768841
124replication fork processing (GO:0031297)2.88791019
125regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.88095932
126mitotic spindle checkpoint (GO:0071174)2.87683039
127spliceosomal complex assembly (GO:0000245)2.87109064
128* mitotic cell cycle (GO:0000278)2.86916304
129negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.86460109
130regulation of chromosome segregation (GO:0051983)2.86451371
131regulation of DNA endoreduplication (GO:0032875)2.85991841

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.70896597
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.68060865
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.93728151
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.67894650
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.59160518
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.94332473
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.92669254
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.74183056
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68081075
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.65498682
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63636884
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58135092
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.54152099
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.47108301
15AR_21909140_ChIP-Seq_LNCAP_Human2.45988398
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.42860656
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.40520979
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.33885896
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25830875
20MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.24009712
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.23238790
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20050292
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17902876
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.13312807
25VDR_23849224_ChIP-Seq_CD4+_Human2.07428868
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00773484
27XRN2_22483619_ChIP-Seq_HELA_Human2.00467711
28E2F7_22180533_ChIP-Seq_HELA_Human11.7582625
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92134061
30ELK1_19687146_ChIP-ChIP_HELA_Human1.90726901
31DCP1A_22483619_ChIP-Seq_HELA_Human1.90051606
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.89615620
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88287077
34* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88086218
35FOXP3_21729870_ChIP-Seq_TREG_Human1.86073044
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84655251
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84451079
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.82808971
39MYC_22102868_ChIP-Seq_BL_Human1.79816749
40TTF2_22483619_ChIP-Seq_HELA_Human1.76939987
41* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67368123
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65844934
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61524151
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60106905
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56631328
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55389346
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54103290
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49041749
49GABP_19822575_ChIP-Seq_HepG2_Human1.48352616
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.47257225
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46298500
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.46247279
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.46056427
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40906244
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37019958
56ZNF263_19887448_ChIP-Seq_K562_Human1.27668444
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27042266
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24093411
59CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24051040
60CIITA_25753668_ChIP-Seq_RAJI_Human1.19819692
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19789985
62VDR_21846776_ChIP-Seq_THP-1_Human1.17893865
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15090183
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14979253
65KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13695671
66MYC_18940864_ChIP-ChIP_HL60_Human1.13542149
67KDM5A_27292631_Chip-Seq_BREAST_Human1.11741629
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11144341
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11134351
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11121097
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08368952
72CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08172289
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07705464
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.05344692
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05138714
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03928483
77SALL1_21062744_ChIP-ChIP_HESCs_Human1.02550176
78SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01924201
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96565762
80RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96112567
81SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95902509
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95832670
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94972480
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94632129
85IRF1_19129219_ChIP-ChIP_H3396_Human0.93159204
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88444812
87TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86970912
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85806538
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85668521
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83860426
91POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83304989
92TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.82555774
93TBX5_21415370_ChIP-Seq_HL-1_Mouse0.81772475
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81095778
95SPI1_23547873_ChIP-Seq_NB4_Human0.80221434
96IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.79927414
97SOX17_20123909_ChIP-Seq_XEN_Mouse0.79476047
98STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79044777
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.78083070
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77874515
101ELK1_22589737_ChIP-Seq_MCF10A_Human0.76911962
102FOXP1_21924763_ChIP-Seq_HESCs_Human0.76167869
103TFEB_21752829_ChIP-Seq_HELA_Human0.75872187
104NANOG_16153702_ChIP-ChIP_HESCs_Human0.75588744
105NANOG_21062744_ChIP-ChIP_HESCs_Human0.75209805
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73653486
107CTCF_18555785_ChIP-Seq_MESCs_Mouse0.73277845
108KLF4_18555785_ChIP-Seq_MESCs_Mouse0.72483072
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.71892657
110NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71504903
111POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.67038507
112EWS_26573619_Chip-Seq_HEK293_Human0.65863115
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.64044510
114TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.63688534
115SOX2_16153702_ChIP-ChIP_HESCs_Human0.63044176
116KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.62375397
117IRF8_21731497_ChIP-ChIP_J774_Mouse0.61978596
118TCF3_18692474_ChIP-Seq_MEFs_Mouse0.61940158
119DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.61458136
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.61220676
121CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.56889406

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.23820644
2MP0010094_abnormal_chromosome_stability5.04701026
3MP0003111_abnormal_nucleus_morphology4.42264230
4MP0008057_abnormal_DNA_replication4.31176814
5MP0008058_abnormal_DNA_repair3.97232359
6MP0003077_abnormal_cell_cycle3.76408830
7MP0004957_abnormal_blastocyst_morpholog3.62941795
8MP0008007_abnormal_cellular_replicative2.78177392
9MP0008932_abnormal_embryonic_tissue2.60625777
10MP0002396_abnormal_hematopoietic_system2.53818785
11MP0003123_paternal_imprinting2.26648934
12MP0003786_premature_aging2.16581385
13MP0002877_abnormal_melanocyte_morpholog2.04076976
14MP0006292_abnormal_olfactory_placode1.92068323
15MP0008877_abnormal_DNA_methylation1.91243860
16MP0000350_abnormal_cell_proliferation1.80017578
17MP0000566_synostosis1.79482553
18MP0000490_abnormal_crypts_of1.74759604
19MP0003718_maternal_effect1.68597331
20MP0010030_abnormal_orbit_morphology1.59958464
21MP0003121_genomic_imprinting1.55328248
22MP0001730_embryonic_growth_arrest1.51950636
23MP0001346_abnormal_lacrimal_gland1.49863269
24MP0003941_abnormal_skin_development1.48502393
25MP0003806_abnormal_nucleotide_metabolis1.44998506
26MP0010307_abnormal_tumor_latency1.39196168
27MP0004808_abnormal_hematopoietic_stem1.39089744
28MP0003315_abnormal_perineum_morphology1.37736032
29MP0002102_abnormal_ear_morphology1.37339713
30MP0002132_abnormal_respiratory_system1.36137139
31MP0001672_abnormal_embryogenesis/_devel1.32640618
32MP0005380_embryogenesis_phenotype1.32640618
33MP0002234_abnormal_pharynx_morphology1.27339250
34MP0009672_abnormal_birth_weight1.27026050
35MP0010352_gastrointestinal_tract_polyps1.26510514
36MP0000313_abnormal_cell_death1.25997753
37MP0002938_white_spotting1.25275770
38MP0005076_abnormal_cell_differentiation1.20967661
39MP0002019_abnormal_tumor_incidence1.19059597
40MP0001697_abnormal_embryo_size1.18889846
41MP0004185_abnormal_adipocyte_glucose1.18388098
42MP0001293_anophthalmia1.16037847
43MP0002085_abnormal_embryonic_tissue1.14421830
44MP0002210_abnormal_sex_determination1.14044395
45MP0000358_abnormal_cell_content/1.11443209
46MP0003984_embryonic_growth_retardation1.10945073
47MP0004147_increased_porphyrin_level1.10227934
48MP0002088_abnormal_embryonic_growth/wei1.08818840
49MP0003567_abnormal_fetal_cardiomyocyte1.07791080
50MP0002080_prenatal_lethality1.07415456
51MP0001188_hyperpigmentation1.05819833
52MP0006035_abnormal_mitochondrial_morpho1.04944166
53MP0009053_abnormal_anal_canal1.04766488
54MP0009333_abnormal_splenocyte_physiolog1.03631758
55MP0009379_abnormal_foot_pigmentation1.01574954
56MP0003136_yellow_coat_color1.01194199
57MP0005501_abnormal_skin_physiology1.01117019
58MP0001119_abnormal_female_reproductive1.00217181
59MP0000537_abnormal_urethra_morphology0.98588171
60MP0003890_abnormal_embryonic-extraembry0.98027325
61MP0004197_abnormal_fetal_growth/weight/0.97877467
62MP0006036_abnormal_mitochondrial_physio0.97599921
63MP0002697_abnormal_eye_size0.97021975
64MP0003937_abnormal_limbs/digits/tail_de0.96428628
65MP0002163_abnormal_gland_morphology0.94467908
66MP0003763_abnormal_thymus_physiology0.94117917
67MP0003186_abnormal_redox_activity0.93937472
68MP0003385_abnormal_body_wall0.93508280
69MP0000049_abnormal_middle_ear0.93455787
70MP0001145_abnormal_male_reproductive0.92602089
71MP0002095_abnormal_skin_pigmentation0.91122065
72MP0002086_abnormal_extraembryonic_tissu0.91014884
73MP0001545_abnormal_hematopoietic_system0.91000129
74MP0005397_hematopoietic_system_phenotyp0.91000129
75MP0000703_abnormal_thymus_morphology0.90869494
76MP0005075_abnormal_melanosome_morpholog0.90002994
77MP0000678_abnormal_parathyroid_gland0.89920403
78MP0005389_reproductive_system_phenotype0.88799387
79MP0008789_abnormal_olfactory_epithelium0.88580623
80MP0002160_abnormal_reproductive_system0.88135359
81MP0005623_abnormal_meninges_morphology0.87814761
82MP0009697_abnormal_copulation0.86979691
83MP0003938_abnormal_ear_development0.85975011
84MP0002111_abnormal_tail_morphology0.85694087
85MP0004381_abnormal_hair_follicle0.85435067
86MP0002398_abnormal_bone_marrow0.85287047
87MP0002092_abnormal_eye_morphology0.84000368
88MP0002084_abnormal_developmental_patter0.83382635
89MP0000383_abnormal_hair_follicle0.83157255
90MP0004233_abnormal_muscle_weight0.83112374
91MP0001853_heart_inflammation0.81871112
92MP0000428_abnormal_craniofacial_morphol0.81357527
93MP0005384_cellular_phenotype0.80701141
94MP0000653_abnormal_sex_gland0.80694278
95MP0002722_abnormal_immune_system0.80454843
96MP0002277_abnormal_respiratory_mucosa0.80447029
97MP0001661_extended_life_span0.80356226
98MP0005174_abnormal_tail_pigmentation0.78816706
99MP0003705_abnormal_hypodermis_morpholog0.78804030
100MP0001286_abnormal_eye_development0.78145672
101MP0009278_abnormal_bone_marrow0.77231478
102MP0001881_abnormal_mammary_gland0.75130650
103MP0005408_hypopigmentation0.74708369
104MP0001727_abnormal_embryo_implantation0.73894401
105MP0001929_abnormal_gametogenesis0.73892250
106MP0000689_abnormal_spleen_morphology0.73487786
107MP0000858_altered_metastatic_potential0.73286140
108MP0001529_abnormal_vocalization0.72657265
109MP0003942_abnormal_urinary_system0.72394476
110MP0005621_abnormal_cell_physiology0.72188906
111MP0001186_pigmentation_phenotype0.71359738
112MP0000015_abnormal_ear_pigmentation0.71151692
113MP0005394_taste/olfaction_phenotype0.70728626
114MP0005499_abnormal_olfactory_system0.70728626
115MP0001919_abnormal_reproductive_system0.69784020
116MP0002429_abnormal_blood_cell0.68229006
117MP0002249_abnormal_larynx_morphology0.67611218
118MP0004133_heterotaxia0.67509460
119MP0003787_abnormal_imprinting0.66996729
120MP0001835_abnormal_antigen_presentation0.66510054
121MP0002009_preneoplasia0.64815282
122MP0002075_abnormal_coat/hair_pigmentati0.64178882
123MP0003699_abnormal_female_reproductive0.63618826
124MP0003861_abnormal_nervous_system0.63577827
125MP0003936_abnormal_reproductive_system0.61243722
126MP0002006_tumorigenesis0.60473237
127MP0000432_abnormal_head_morphology0.59376709
128MP0003119_abnormal_digestive_system0.59176056
129MP0002114_abnormal_axial_skeleton0.59147745
130MP0002161_abnormal_fertility/fecundity0.57942872
131MP0003755_abnormal_palate_morphology0.57690334
132MP0000716_abnormal_immune_system0.57359894
133MP0005171_absent_coat_pigmentation0.55898935
134MP0002751_abnormal_autonomic_nervous0.55441096
135MP0009250_abnormal_appendicular_skeleto0.54766426
136MP0002148_abnormal_hypersensitivity_rea0.54372083
137MP0003943_abnormal_hepatobiliary_system0.53461128
138MP0002970_abnormal_white_adipose0.52190481
139MP0002233_abnormal_nose_morphology0.51761956
140MP0003935_abnormal_craniofacial_develop0.51137993
141MP0005451_abnormal_body_composition0.50841308

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.76724885
2Chromsome breakage (HP:0040012)5.70925324
3Birth length less than 3rd percentile (HP:0003561)4.77860634
4Reticulocytopenia (HP:0001896)4.19035103
5Meckel diverticulum (HP:0002245)4.13955946
6Abnormality of chromosome stability (HP:0003220)4.06438916
7Abnormality of the preputium (HP:0100587)3.97989223
8Abnormality of the ileum (HP:0001549)3.95451684
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.74944426
10Breast hypoplasia (HP:0003187)3.40790563
11Patellar aplasia (HP:0006443)3.37650390
12Duplicated collecting system (HP:0000081)3.19704730
13Aplasia/Hypoplasia of the patella (HP:0006498)3.17750706
14Duodenal stenosis (HP:0100867)3.14212810
15Small intestinal stenosis (HP:0012848)3.14212810
16Ectopic kidney (HP:0000086)3.10343069
17Abnormality of the renal collecting system (HP:0004742)2.99519068
18Nephroblastoma (Wilms tumor) (HP:0002667)2.95076842
19Abnormal number of erythroid precursors (HP:0012131)2.94332373
20Absent radius (HP:0003974)2.92920415
21Abnormality of cells of the erythroid lineage (HP:0012130)2.92058107
22Impulsivity (HP:0100710)2.85170496
23Bone marrow hypocellularity (HP:0005528)2.83934909
24Embryonal renal neoplasm (HP:0011794)2.76711371
25Triphalangeal thumb (HP:0001199)2.76441024
26Absent forearm bone (HP:0003953)2.74740825
27Aplasia involving forearm bones (HP:0009822)2.74740825
28Abnormal lung lobation (HP:0002101)2.73680338
2911 pairs of ribs (HP:0000878)2.73193819
30Absent thumb (HP:0009777)2.68079486
31Myelodysplasia (HP:0002863)2.67849916
32Clubbing of toes (HP:0100760)2.67710688
33Proximal placement of thumb (HP:0009623)2.64446596
34Oral leukoplakia (HP:0002745)2.63420055
35Selective tooth agenesis (HP:0001592)2.60952281
36Progressive muscle weakness (HP:0003323)2.60343925
37Multiple enchondromatosis (HP:0005701)2.56645264
38Abnormality of cochlea (HP:0000375)2.56017814
39Abnormality of the duodenum (HP:0002246)2.52353028
40Premature graying of hair (HP:0002216)2.51393022
41Abnormality of the carotid arteries (HP:0005344)2.51150522
42Colon cancer (HP:0003003)2.49732578
43Abnormality of reticulocytes (HP:0004312)2.48062356
44Abnormality of glycolysis (HP:0004366)2.42918973
45Deviation of the thumb (HP:0009603)2.41900108
46Sloping forehead (HP:0000340)2.41411403
47Abnormal number of incisors (HP:0011064)2.40747085
48Medulloblastoma (HP:0002885)2.39654525
49Rough bone trabeculation (HP:0100670)2.37667175
50Aplastic anemia (HP:0001915)2.37565498
51Pallor (HP:0000980)2.37105635
52Short thumb (HP:0009778)2.35005889
53Tracheoesophageal fistula (HP:0002575)2.32648980
54Abnormality of DNA repair (HP:0003254)2.32361672
55Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.32104047
56Absent epiphyses (HP:0010577)2.32104047
57Aplasia/Hypoplasia of the sacrum (HP:0008517)2.30196128
58Poikiloderma (HP:0001029)2.29445652
59Carpal bone hypoplasia (HP:0001498)2.23960917
60Overlapping toe (HP:0001845)2.23231053
61Macrocytic anemia (HP:0001972)2.23162303
62Broad distal phalanx of finger (HP:0009836)2.21958362
63Horseshoe kidney (HP:0000085)2.20767172
64Volvulus (HP:0002580)2.20525978
65Cleft eyelid (HP:0000625)2.18829832
66High pitched voice (HP:0001620)2.12451354
67Insomnia (HP:0100785)2.10601196
68Hyperacusis (HP:0010780)2.10433951
69Supernumerary spleens (HP:0009799)2.10318756
70Increased serum pyruvate (HP:0003542)2.08415004
71Cholecystitis (HP:0001082)2.06823080
72Abnormal gallbladder physiology (HP:0012438)2.06823080
73Abnormality of the labia minora (HP:0012880)2.06670617
74Irregular epiphyses (HP:0010582)2.04973105
75Neoplasm of the pancreas (HP:0002894)2.03212553
76Abnormal mitochondria in muscle tissue (HP:0008316)2.01364597
77Cortical dysplasia (HP:0002539)2.00296539
78Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.99443003
79Short 4th metacarpal (HP:0010044)1.99443003
80Abnormal trabecular bone morphology (HP:0100671)1.98849337
81Abnormality of the anterior horn cell (HP:0006802)1.96454291
82Degeneration of anterior horn cells (HP:0002398)1.96454291
83Cellular immunodeficiency (HP:0005374)1.95753250
84Prostate neoplasm (HP:0100787)1.94789870
85Short middle phalanx of the 5th finger (HP:0004220)1.94497602
86Duplication of thumb phalanx (HP:0009942)1.94007458
87Morphological abnormality of the inner ear (HP:0011390)1.92316138
88Agnosia (HP:0010524)1.92121267
89Trismus (HP:0000211)1.92035336
90Pancytopenia (HP:0001876)1.90713054
91Microretrognathia (HP:0000308)1.90263505
92Ragged-red muscle fibers (HP:0003200)1.89880351
93Abnormality of pyrimidine metabolism (HP:0004353)1.89798886
94Facial cleft (HP:0002006)1.88041245
95Atresia of the external auditory canal (HP:0000413)1.84760019
96Aplasia/Hypoplasia of the earlobes (HP:0009906)1.84710775
97Microvesicular hepatic steatosis (HP:0001414)1.84087910
98Abnormality of the umbilical cord (HP:0010881)1.81423011
99High anterior hairline (HP:0009890)1.80774773
100Choanal atresia (HP:0000453)1.80612623
101Abnormality of the heme biosynthetic pathway (HP:0010472)1.79879550
102Hypoplastic pelvis (HP:0008839)1.79741259
103Lymphoma (HP:0002665)1.79435500
104Entropion (HP:0000621)1.79062644
105Small epiphyses (HP:0010585)1.78755974
106Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75911718
107Acute necrotizing encephalopathy (HP:0006965)1.75119380
108Type I transferrin isoform profile (HP:0003642)1.74727312
109Ureteral duplication (HP:0000073)1.73030170
110Acute encephalopathy (HP:0006846)1.69763659
111Hypoplasia of the radius (HP:0002984)1.68876411
112Arteriovenous malformation (HP:0100026)1.68534051
113Leukopenia (HP:0001882)1.68379027
114Overriding aorta (HP:0002623)1.67897596
115Squamous cell carcinoma (HP:0002860)1.65915575
116Renal duplication (HP:0000075)1.65786151
117Reticulocytosis (HP:0001923)1.65096034
118Optic nerve coloboma (HP:0000588)1.64240499
119Abnormal spermatogenesis (HP:0008669)1.64190705
120Rhabdomyosarcoma (HP:0002859)1.64112127
121Abnormality of the calcaneus (HP:0008364)1.64109588
122Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.63759527
123Orthostatic hypotension (HP:0001278)1.63482695
124Abdominal situs inversus (HP:0003363)1.62199679
125Abnormality of abdominal situs (HP:0011620)1.62199679
126Increased nuchal translucency (HP:0010880)1.60672451
127Pseudobulbar signs (HP:0002200)1.60188343
128Aplasia/Hypoplasia of the sternum (HP:0006714)1.59963747
129Cafe-au-lait spot (HP:0000957)1.57734745
130Hypopigmented skin patches (HP:0001053)1.56984533
131Microtia (HP:0008551)1.56977073
132Abnormality of the fetal cardiovascular system (HP:0010948)1.53879057
133Abnormal umbilical cord blood vessels (HP:0011403)1.53879057
134Single umbilical artery (HP:0001195)1.53879057
135Tetralogy of Fallot (HP:0001636)1.53715296
136Slender long bone (HP:0003100)1.53223903
137Abnormality of the incisor (HP:0000676)1.52915075
138Abnormality of the prostate (HP:0008775)1.52332921
139Oligohydramnios (HP:0001562)1.50353800

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.24791385
2WEE14.12952431
3BUB14.09535363
4VRK23.96159274
5SRPK13.08681665
6SMG12.86510638
7EIF2AK12.84817275
8STK162.78906143
9PLK42.77197056
10TTK2.43037334
11TAF12.39478226
12NEK22.36726323
13PASK2.25284066
14ZAK2.22657704
15VRK12.22547387
16BRSK22.15968975
17PLK12.11933566
18MKNK12.09373382
19EIF2AK21.98544252
20TLK11.92938413
21ATR1.92600926
22EIF2AK31.87483276
23CCNB11.84454434
24AURKB1.83817376
25MAP3K91.79123247
26ACVR1B1.76984280
27TSSK61.71454727
28CDK71.69287628
29NME21.67155763
30PLK31.63726098
31MKNK21.61757641
32DYRK31.59031707
33STK41.54454616
34CHEK21.52560795
35BRSK11.47051551
36NEK11.46631364
37MAP3K101.39662681
38RPS6KA41.37532609
39EPHA21.28775444
40CLK11.27765686
41BCKDK1.21592155
42PBK1.21352067
43IRAK31.16094980
44CHEK11.09774896
45CDK41.09348791
46AURKA1.08242260
47YES11.06961054
48CDK81.02889144
49ARAF0.99610680
50IRAK40.99471077
51RPS6KB20.98976371
52ATM0.93857429
53MAP3K80.93590199
54AKT30.89869360
55PIM10.85312935
56CDK90.83427322
57ICK0.82425727
58BRD40.81596082
59EEF2K0.80295327
60STK100.79541702
61BLK0.79407636
62RPS6KA50.77868821
63NUAK10.77667671
64STK240.77549176
65STK30.76560483
66TRIB30.74650691
67CDK11A0.74523848
68DAPK10.74194140
69CDK120.72987133
70STK38L0.72688559
71* CSNK2A10.71631441
72CDK20.71077920
73CDK150.70895891
74MELK0.70544453
75MST40.68417430
76CDK180.67369495
77PIM20.67270559
78TGFBR10.66960057
79TEC0.65113724
80CDK140.64862130
81CDK10.62838456
82PAK40.61426972
83BRAF0.61110299
84TXK0.60701378
85CSNK1G30.58937879
86GRK10.56847162
87* CSNK2A20.56389767
88TESK20.55874509
89MAP3K140.51443373
90CSNK1A1L0.50617581
91MAPK110.47805035
92LRRK20.47530726
93ERBB30.47117909
94NME10.44507906
95RAF10.43755126
96PAK10.42188122
97CDK60.42077903
98KDR0.40612697
99PIK3CG0.40089851
100IKBKB0.39921443
101SIK30.37116266
102CHUK0.36160861
103KSR20.35804830
104MAPKAPK50.35221232
105FLT30.35087807
106MST1R0.34469844
107PRKCI0.34290130
108BMPR1B0.33455316
109DYRK20.33330326
110TESK10.32963825
111PRKDC0.32856129
112ALK0.31411432
113CDK30.30545672
114PRPF4B0.30217802
115BTK0.29375837
116CSNK1G10.29226522
117LYN0.28580570
118NLK0.28571376
119NEK90.28223696
120AKT20.27815809
121MTOR0.27774582
122AKT10.27096573
123PKN20.26646133
124TAOK20.26266384
125ILK0.25871498
126CSNK1E0.24766363
127MOS0.24302878
128RPS6KC10.24242441
129RPS6KL10.24242441
130ERBB40.23497960
131MAPK140.22013972
132PNCK0.21843603
133SCYL20.21058579
134RPS6KA60.20965678
135BCR0.20126902
136BMPR20.18340930

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.49044057
2Mismatch repair_Homo sapiens_hsa034304.60815624
3Homologous recombination_Homo sapiens_hsa034403.69563448
4Base excision repair_Homo sapiens_hsa034103.32507441
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.10074397
6Nucleotide excision repair_Homo sapiens_hsa034203.09074699
7Fanconi anemia pathway_Homo sapiens_hsa034603.05534056
8Proteasome_Homo sapiens_hsa030503.04861684
9Ribosome_Homo sapiens_hsa030103.02136291
10Spliceosome_Homo sapiens_hsa030402.90997014
11RNA polymerase_Homo sapiens_hsa030202.82580383
12Cell cycle_Homo sapiens_hsa041102.80133770
13Non-homologous end-joining_Homo sapiens_hsa034502.72785419
14RNA transport_Homo sapiens_hsa030132.55348773
15* Pyrimidine metabolism_Homo sapiens_hsa002402.50428117
16* One carbon pool by folate_Homo sapiens_hsa006702.30111304
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87508589
18Basal transcription factors_Homo sapiens_hsa030221.83006960
19RNA degradation_Homo sapiens_hsa030181.74639458
20p53 signaling pathway_Homo sapiens_hsa041151.73328246
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61544664
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59711449
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51606650
24Systemic lupus erythematosus_Homo sapiens_hsa053221.46996290
25mRNA surveillance pathway_Homo sapiens_hsa030151.41251404
26Purine metabolism_Homo sapiens_hsa002301.39207841
27Carbon metabolism_Homo sapiens_hsa012001.28238043
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22149799
29Epstein-Barr virus infection_Homo sapiens_hsa051691.07656409
30Herpes simplex infection_Homo sapiens_hsa051681.05115503
31Pyruvate metabolism_Homo sapiens_hsa006201.03964685
32Fatty acid elongation_Homo sapiens_hsa000620.93369475
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87983421
34Viral carcinogenesis_Homo sapiens_hsa052030.83971319
35Folate biosynthesis_Homo sapiens_hsa007900.82888588
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80820442
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80358033
38Protein export_Homo sapiens_hsa030600.78735591
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77864106
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76448953
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76248530
42Bladder cancer_Homo sapiens_hsa052190.74722523
43HTLV-I infection_Homo sapiens_hsa051660.70660665
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70218569
45Graft-versus-host disease_Homo sapiens_hsa053320.69470354
46Small cell lung cancer_Homo sapiens_hsa052220.69397641
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.69378434
48Glutathione metabolism_Homo sapiens_hsa004800.68470722
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.68280315
50Fructose and mannose metabolism_Homo sapiens_hsa000510.67959735
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.66651192
52Antigen processing and presentation_Homo sapiens_hsa046120.65055243
53Legionellosis_Homo sapiens_hsa051340.64931421
54Measles_Homo sapiens_hsa051620.63012326
55Primary immunodeficiency_Homo sapiens_hsa053400.62282362
56MicroRNAs in cancer_Homo sapiens_hsa052060.61012892
57Allograft rejection_Homo sapiens_hsa053300.60853490
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60505780
59Oocyte meiosis_Homo sapiens_hsa041140.59443626
60Alzheimers disease_Homo sapiens_hsa050100.57399931
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56667577
62Lysine degradation_Homo sapiens_hsa003100.56656038
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.56069993
64Hematopoietic cell lineage_Homo sapiens_hsa046400.54526307
65Galactose metabolism_Homo sapiens_hsa000520.54252225
66Pancreatic cancer_Homo sapiens_hsa052120.53126273
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52808655
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52527408
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52097042
70Huntingtons disease_Homo sapiens_hsa050160.50435953
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48519192
72Chronic myeloid leukemia_Homo sapiens_hsa052200.48126444
73Vitamin B6 metabolism_Homo sapiens_hsa007500.47300933
74Autoimmune thyroid disease_Homo sapiens_hsa053200.46995873
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45629191
76Arachidonic acid metabolism_Homo sapiens_hsa005900.45442360
77Basal cell carcinoma_Homo sapiens_hsa052170.45440818
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45148342
79Apoptosis_Homo sapiens_hsa042100.43647422
80Asthma_Homo sapiens_hsa053100.43069303
81Pentose phosphate pathway_Homo sapiens_hsa000300.42358858
82Alcoholism_Homo sapiens_hsa050340.40536776
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.40114051
84Hepatitis B_Homo sapiens_hsa051610.38388417
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36877987
86Influenza A_Homo sapiens_hsa051640.36413653
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35912458
88Non-small cell lung cancer_Homo sapiens_hsa052230.35595237
89Selenocompound metabolism_Homo sapiens_hsa004500.34818697
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.34256737
91Steroid biosynthesis_Homo sapiens_hsa001000.33849259
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30244433
93Colorectal cancer_Homo sapiens_hsa052100.29426568
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29306967
95TGF-beta signaling pathway_Homo sapiens_hsa043500.28644334
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28241274
97Fatty acid metabolism_Homo sapiens_hsa012120.27202850
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26637540
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25340928
100Parkinsons disease_Homo sapiens_hsa050120.25093330
101Propanoate metabolism_Homo sapiens_hsa006400.24176532
102Hippo signaling pathway_Homo sapiens_hsa043900.23419339
103Prostate cancer_Homo sapiens_hsa052150.23090175
104Vitamin digestion and absorption_Homo sapiens_hsa049770.23017272
105* Metabolic pathways_Homo sapiens_hsa011000.22999152
106Pathways in cancer_Homo sapiens_hsa052000.22442635
107Sulfur relay system_Homo sapiens_hsa041220.22208213
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21749209
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21540085
110Thyroid cancer_Homo sapiens_hsa052160.21312835
111Hedgehog signaling pathway_Homo sapiens_hsa043400.19997169
112Renin-angiotensin system_Homo sapiens_hsa046140.19911794
113N-Glycan biosynthesis_Homo sapiens_hsa005100.18008440
114Wnt signaling pathway_Homo sapiens_hsa043100.16537473
115Malaria_Homo sapiens_hsa051440.16108441
116Melanoma_Homo sapiens_hsa052180.16102468
117Viral myocarditis_Homo sapiens_hsa054160.15770519
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.14117149
119Oxidative phosphorylation_Homo sapiens_hsa001900.13593411
120Notch signaling pathway_Homo sapiens_hsa043300.13510322
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.13122074
122Arginine and proline metabolism_Homo sapiens_hsa003300.11366371
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10499529
124Leishmaniasis_Homo sapiens_hsa051400.09821379
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.09429988
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.09086259
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.08433873
128Linoleic acid metabolism_Homo sapiens_hsa005910.07571835
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07471508
130Biosynthesis of amino acids_Homo sapiens_hsa012300.07391244
131Shigellosis_Homo sapiens_hsa051310.07186941

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