TYR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanocyte differentiation (GO:0030318)8.67718716
2ketone body metabolic process (GO:1902224)8.60743525
3* tyrosine metabolic process (GO:0006570)8.07188926
4pigment cell differentiation (GO:0050931)7.99326683
5melanosome organization (GO:0032438)7.31988764
6* pigment biosynthetic process (GO:0046148)7.31542113
7pigment granule organization (GO:0048753)7.06225049
8endosome to pigment granule transport (GO:0043485)6.48730682
9endosome to melanosome transport (GO:0035646)6.48730682
10neuroepithelial cell differentiation (GO:0060563)5.87490394
11* pigment metabolic process (GO:0042440)5.64050777
12pigmentation (GO:0043473)5.53895223
13vitamin A metabolic process (GO:0006776)5.26722020
14myotube differentiation (GO:0014902)5.14692803
15mesenchymal-epithelial cell signaling (GO:0060638)5.11066948
16positive regulation of neuroblast proliferation (GO:0002052)5.06860871
17regulation of endothelial cell chemotaxis (GO:2001026)4.89011098
18enteric nervous system development (GO:0048484)4.34955171
19negative regulation of hydrogen peroxide-induced cell death (GO:1903206)4.34771821
20melanosome localization (GO:0032400)4.31875179
21melanosome transport (GO:0032402)4.29373439
22regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.28818555
23pigment granule localization (GO:0051875)4.20145874
24pigment granule transport (GO:0051904)4.16158399
25establishment of melanosome localization (GO:0032401)4.11481675
26basement membrane organization (GO:0071711)4.02473399
27* melanin biosynthetic process (GO:0042438)33.5257053
28* melanin metabolic process (GO:0006582)30.3640855
29establishment of pigment granule localization (GO:0051905)3.99619104
30* phenol-containing compound metabolic process (GO:0018958)3.84836263
31regulation of hydrogen peroxide-induced cell death (GO:1903205)3.80366682
32negative regulation of response to reactive oxygen species (GO:1901032)3.79565658
33regulation of integrin-mediated signaling pathway (GO:2001044)3.75223010
34columnar/cuboidal epithelial cell differentiation (GO:0002065)3.69490014
35somatic stem cell division (GO:0048103)3.67946577
36negative regulation of macroautophagy (GO:0016242)3.62347691
37regulation of neuroblast proliferation (GO:1902692)3.57001477
38endothelial cell morphogenesis (GO:0001886)3.56589029
39proline transport (GO:0015824)3.49070824
40regulation of protein sumoylation (GO:0033233)3.45582943
41short-chain fatty acid metabolic process (GO:0046459)3.40304279
42calcium-mediated signaling using intracellular calcium source (GO:0035584)3.37358041
43retinal rod cell development (GO:0046548)3.28870181
44antigen processing and presentation via MHC class Ib (GO:0002475)3.27539078
45regulation of early endosome to late endosome transport (GO:2000641)3.19710097
46peripheral nervous system development (GO:0007422)3.15464436
47platelet dense granule organization (GO:0060155)3.07735622
48* secondary metabolite biosynthetic process (GO:0044550)27.4201978
49bone remodeling (GO:0046849)2.99445054
50cellular response to nitric oxide (GO:0071732)2.97045772
51nerve growth factor signaling pathway (GO:0038180)2.95341105
52chondroitin sulfate catabolic process (GO:0030207)2.93731040
53cellular response to reactive nitrogen species (GO:1902170)2.89786812
54barbed-end actin filament capping (GO:0051016)2.88151488
55muscle cell migration (GO:0014812)2.86606092
56regulation of somitogenesis (GO:0014807)2.84204800
57sialylation (GO:0097503)2.82229473
58regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.78900529
59cGMP-mediated signaling (GO:0019934)2.78312839
60protein K6-linked ubiquitination (GO:0085020)2.74943617
61semaphorin-plexin signaling pathway (GO:0071526)2.74339535
62regulation of centriole replication (GO:0046599)2.70421437
63positive regulation of receptor recycling (GO:0001921)2.68849175
64neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.66879903
65dosage compensation (GO:0007549)2.61246546
66peptidyl-proline hydroxylation (GO:0019511)2.57079366
67positive regulation of neural precursor cell proliferation (GO:2000179)2.56092768
68negative regulation of transcription by competitive promoter binding (GO:0010944)2.52452789
69behavioral response to ethanol (GO:0048149)2.51892334
70fusion of sperm to egg plasma membrane (GO:0007342)2.49521448
71regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.43809367
72keratinocyte development (GO:0003334)2.43525698
73fibroblast migration (GO:0010761)2.38432537
74cornea development in camera-type eye (GO:0061303)2.37879044
75intracellular pH reduction (GO:0051452)2.37806791
76regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.36595645
77Rap protein signal transduction (GO:0032486)2.36282401
78autophagic vacuole fusion (GO:0000046)2.35960689
79stem cell division (GO:0017145)2.33872260
80response to nitric oxide (GO:0071731)2.32819426
81alanine transport (GO:0032328)2.30922230
82regulation of superoxide anion generation (GO:0032928)2.30507655
83secretory granule organization (GO:0033363)2.27593233
84inositol phosphate dephosphorylation (GO:0046855)2.25610131
85phosphorylated carbohydrate dephosphorylation (GO:0046838)2.25610131
86mitotic G1 DNA damage checkpoint (GO:0031571)2.23645201
87antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.23616665
88neural crest cell migration (GO:0001755)2.23120256
89negative regulation of oxidative stress-induced cell death (GO:1903202)2.20906499
90oligodendrocyte differentiation (GO:0048709)2.20090247
91response to methylmercury (GO:0051597)2.19638729
92positive regulation of DNA-dependent DNA replication (GO:2000105)2.19024571
93retinal metabolic process (GO:0042574)2.17628564
94inositol phosphate catabolic process (GO:0071545)2.17526439
95specification of organ identity (GO:0010092)2.16019770
96vesicle localization (GO:0051648)2.15185060
97pH reduction (GO:0045851)2.13706710
98response to thyroid hormone (GO:0097066)2.12031589
99osteoclast differentiation (GO:0030316)2.11383400
100embryonic body morphogenesis (GO:0010172)2.09840890
101protein-chromophore linkage (GO:0018298)2.06194902
102regulation of sister chromatid cohesion (GO:0007063)2.06054585
103negative regulation of response to oxidative stress (GO:1902883)2.05775635
104negative regulation of cellular response to oxidative stress (GO:1900408)2.05775635
105regulation of response to reactive oxygen species (GO:1901031)2.05134589
106vesicle organization (GO:0016050)2.04687674
107Rac protein signal transduction (GO:0016601)2.03496979
108acrosome reaction (GO:0007340)2.03384472
109negative regulation of response to nutrient levels (GO:0032108)2.03095543
110negative regulation of response to extracellular stimulus (GO:0032105)2.03095543
111protein hydroxylation (GO:0018126)2.02251650
112organelle membrane fusion (GO:0090174)2.01883837
113membrane protein ectodomain proteolysis (GO:0006509)2.00202853
114negative regulation of organelle assembly (GO:1902116)2.00099968
115developmental pigmentation (GO:0048066)13.4339140
116* phenol-containing compound biosynthetic process (GO:0046189)10.4365403
117* secondary metabolic process (GO:0019748)10.1319837
118Golgi transport vesicle coating (GO:0048200)1.99386961
119COPI coating of Golgi vesicle (GO:0048205)1.99386961
120mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)1.99361180
121cellular response to thyroid hormone stimulus (GO:0097067)1.98906578
122purine ribonucleotide transport (GO:0015868)1.98582665
123negative regulation of glycoprotein biosynthetic process (GO:0010561)1.97756681
124plasma membrane fusion (GO:0045026)1.96896690
125negative regulation of chondrocyte differentiation (GO:0032331)1.96090466
126protein localization to endosome (GO:0036010)1.93481768
127* organic hydroxy compound biosynthetic process (GO:1901617)1.92048488
128regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)1.89994457
129natural killer cell activation involved in immune response (GO:0002323)1.86499416
130mitotic G1/S transition checkpoint (GO:0044819)1.85414390
131myelin assembly (GO:0032288)1.84184803
132* aromatic amino acid family metabolic process (GO:0009072)1.82924226
133centrosome duplication (GO:0051298)1.82016029
134positive regulation of osteoblast proliferation (GO:0033690)1.80885868
135G1 DNA damage checkpoint (GO:0044783)1.80616417
136spinal cord association neuron differentiation (GO:0021527)1.79018853
137positive chemotaxis (GO:0050918)1.73706119
138regulation of apoptotic cell clearance (GO:2000425)1.69141857
139forebrain neuron development (GO:0021884)1.64631252
140dendritic cell migration (GO:0036336)1.63318750
141establishment of mitotic spindle orientation (GO:0000132)1.62115988
142retinol metabolic process (GO:0042572)1.57378509
143negative regulation of membrane potential (GO:0045837)1.55261853
144iron ion import (GO:0097286)1.54732177
145negative regulation of dendrite morphogenesis (GO:0050774)1.51939616
146positive regulation of stem cell proliferation (GO:2000648)1.50986539
147regulation of histone H3-K9 methylation (GO:0051570)1.45252906
148negative regulation of homotypic cell-cell adhesion (GO:0034111)1.44544285
149detection of light stimulus involved in visual perception (GO:0050908)1.44474209
150detection of light stimulus involved in sensory perception (GO:0050962)1.44474209
151angiogenesis involved in wound healing (GO:0060055)1.43697780
152negative regulation of fatty acid biosynthetic process (GO:0045717)1.43573125
153establishment of spindle orientation (GO:0051294)1.41906021
154placenta development (GO:0001890)1.41177075
155eye photoreceptor cell development (GO:0042462)1.40362728
156transferrin transport (GO:0033572)1.39441392
157long-chain fatty acid biosynthetic process (GO:0042759)1.38636257
158cellular glucuronidation (GO:0052695)1.37655069
159chondroitin sulfate biosynthetic process (GO:0030206)1.37365664
160regulation of neural precursor cell proliferation (GO:2000177)1.36646645
161regulation of centrosome duplication (GO:0010824)1.36475289

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat7.64853975
2E2F7_22180533_ChIP-Seq_HELA_Human5.48582530
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.93679623
4GATA1_22025678_ChIP-Seq_K562_Human4.70244578
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.68207488
6CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.02091304
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.01639378
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.62548616
9PIAS1_25552417_ChIP-Seq_VCAP_Human2.42356534
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.38514060
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.37072752
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.35735667
13PCGF2_27294783_Chip-Seq_NPCs_Mouse2.34937845
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32138058
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29324864
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.23062442
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.21666749
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16562039
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.15480375
20ELK1_19687146_ChIP-ChIP_HELA_Human2.10284836
21CDX2_19796622_ChIP-Seq_MESCs_Mouse2.09577220
22RBPJ_22232070_ChIP-Seq_NCS_Mouse10.0304759
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99350732
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.95467781
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.94078620
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.93694737
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.85725859
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84862877
29GBX2_23144817_ChIP-Seq_PC3_Human1.82046145
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76740847
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.74824225
32SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.74646619
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.70331534
34ESR1_15608294_ChIP-ChIP_MCF-7_Human1.70294800
35TP53_18474530_ChIP-ChIP_U2OS_Human1.67673135
36* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67339543
37SOX9_24532713_ChIP-Seq_HFSC_Mouse1.66958615
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.65330321
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.64946008
40TBX20_22328084_ChIP-Seq_HEART_Mouse1.64195039
41TBX20_22080862_ChIP-Seq_HEART_Mouse1.64195039
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64169670
43P300_27058665_Chip-Seq_ZR-75-30cells_Human1.62948238
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.59565728
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59116563
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58488134
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.54393228
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51991821
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50582977
50AR_21909140_ChIP-Seq_LNCAP_Human1.50163986
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47078367
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.46616920
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45784038
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44243535
55ER_23166858_ChIP-Seq_MCF-7_Human1.43300125
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42870319
57GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.42827656
58RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.41622723
59WT1_19549856_ChIP-ChIP_CCG9911_Human1.41050965
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.40866439
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.38573094
62HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.38332147
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.37763211
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37191457
65E2F4_17652178_ChIP-ChIP_JURKAT_Human1.34652885
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.34512210
67EGR1_19032775_ChIP-ChIP_M12_Human1.33084285
68TFEB_21752829_ChIP-Seq_HELA_Human1.31998791
69SOX17_20123909_ChIP-Seq_XEN_Mouse1.29734955
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29132224
71AR_25329375_ChIP-Seq_VCAP_Human1.25857396
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25626281
73TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.25233470
74CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.24214999
75CLOCK_20551151_ChIP-Seq_293T_Human1.23920545
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23289890
77KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20779655
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18879591
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18514437
80MYC_18555785_ChIP-Seq_MESCs_Mouse1.17703545
81P53_22387025_ChIP-Seq_ESCs_Mouse1.17221660
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16586482
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16575503
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16426211
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15738849
86PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15344433
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14959527
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14281815
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14012822
90UBF1/2_26484160_Chip-Seq_HMECs_Human1.13556606
91E2F1_18555785_Chip-Seq_ESCs_Mouse1.12968328
92SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12475026
93* P300_19829295_ChIP-Seq_ESCs_Human1.12198679
94EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12172323
95NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10123401
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.09975499
97FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09647291
98CMYC_18555785_Chip-Seq_ESCs_Mouse1.09219772
99STAT3_23295773_ChIP-Seq_U87_Human1.08893875
100MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08843749
101MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08232477
102EZH2_27294783_Chip-Seq_NPCs_Mouse1.07941117
103* SMAD4_21799915_ChIP-Seq_A2780_Human1.06759528
104HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05513423
105FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05217264
106NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04815909
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.04813944
108YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04544394
109DCP1A_22483619_ChIP-Seq_HELA_Human1.03905585
110MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01884478
111NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.01116253
112GF1B_26923725_Chip-Seq_HPCs_Mouse1.01010806
113KAP1_22055183_ChIP-Seq_ESCs_Mouse1.00263757
114P300_18555785_Chip-Seq_ESCs_Mouse1.00114136
115ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99452635
116EWS_26573619_Chip-Seq_HEK293_Human0.98821847
117E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98802433
118RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98593119
119ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.98169663
120KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98062394
121SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97914081
122PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96737235
123TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94851384
124CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94777803
125STAT3_18555785_Chip-Seq_ESCs_Mouse0.94568525
126SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94171263
127NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93969567
128GATA2_21666600_ChIP-Seq_HMVEC_Human0.93955458
129MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93385879
130Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93039614
131FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.92789778
132MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92559598
133EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92538786
134HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92468463
135CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92298130
136RACK7_27058665_Chip-Seq_MCF-7_Human0.92224304
137AR_21572438_ChIP-Seq_LNCaP_Human0.91830812
138DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91782108
139NMYC_18555785_Chip-Seq_ESCs_Mouse0.91723380
140SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90969834
141SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90969834
142SALL4_22934838_ChIP-ChIP_CD34+_Human0.90522446
143SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89553916
144RUNX1_27457419_Chip-Seq_LIVER_Mouse0.89182645
145LXR_22292898_ChIP-Seq_THP-1_Human0.88951965
146SOX2_18555785_Chip-Seq_ESCs_Mouse0.88797055
147CJUN_26792858_Chip-Seq_BT549_Human0.88468923
148YY1_21170310_ChIP-Seq_MESCs_Mouse0.86866137
149TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86823527
150E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86074058
151KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.85753316
152CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85686145
153ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85291718
154* TAL1_26923725_Chip-Seq_HPCs_Mouse0.85018426
155PU_27001747_Chip-Seq_BMDM_Mouse0.84546836
156SMAD1_18555785_Chip-Seq_ESCs_Mouse0.84543092
157SMAD3_21741376_ChIP-Seq_EPCs_Human0.84034519
158* MITF_21258399_ChIP-Seq_MELANOMA_Human0.83970177
159HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.83842350
160AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83808614
161ZFX_18555785_Chip-Seq_ESCs_Mouse0.82878152
162* TCF4_23295773_ChIP-Seq_U87_Human0.82608060
163FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.82341760
164HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.82001779
165STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81960153
166STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81655710
167GATA4_21415370_ChIP-Seq_HL-1_Mouse0.81526718
168GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81372273
169GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81204223
170KLF4_18555785_Chip-Seq_ESCs_Mouse0.81082291
171VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.80810103
172TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80081387
173IRF8_22096565_ChIP-ChIP_GC-B_Human0.79896004
174SOX2_22085726_ChIP-Seq_NPCs_Mouse0.79643676
175OCT4_18555785_Chip-Seq_ESCs_Mouse0.79526981
176E2F1_17053090_ChIP-ChIP_MCF-7_Human0.79410443
177FUS_26573619_Chip-Seq_HEK293_Human0.78714451
178GABP_19822575_ChIP-Seq_HepG2_Human0.78642858
179OCT4_21477851_ChIP-Seq_ESCs_Mouse0.78537139
180UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.78121646
181PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.76907092

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005171_absent_coat_pigmentation7.22884070
2MP0003136_yellow_coat_color6.99806509
3* MP0005408_hypopigmentation5.00169611
4* MP0000371_diluted_coat_color4.44281219
5MP0000015_abnormal_ear_pigmentation4.35108978
6MP0003878_abnormal_ear_physiology3.78800219
7MP0005377_hearing/vestibular/ear_phenot3.78800219
8MP0002877_abnormal_melanocyte_morpholog3.72302381
9* MP0002095_abnormal_skin_pigmentation3.37010040
10MP0002102_abnormal_ear_morphology3.25671870
11* MP0001324_abnormal_eye_pigmentation2.88993675
12MP0005174_abnormal_tail_pigmentation2.71133990
13* MP0002075_abnormal_coat/hair_pigmentati2.67836735
14* MP0004381_abnormal_hair_follicle2.61870394
15MP0000569_abnormal_digit_pigmentation2.54126228
16* MP0001186_pigmentation_phenotype2.28283606
17MP0002938_white_spotting2.25007810
18* MP0000372_irregular_coat_pigmentation11.0333599
19MP0005248_abnormal_Harderian_gland1.99001358
20MP0002638_abnormal_pupillary_reflex1.89770337
21MP0004885_abnormal_endolymph1.84407842
22MP0003011_delayed_dark_adaptation1.80126491
23MP0005409_darkened_coat_color1.68906637
24MP0005197_abnormal_uvea_morphology1.60517113
25MP0003172_abnormal_lysosome_physiology1.58679576
26* MP0005075_abnormal_melanosome_morpholog1.37908832
27MP0001293_anophthalmia0.93940287
28MP0008260_abnormal_autophagy0.89708646
29MP0009697_abnormal_copulation0.88201008
30* MP0005253_abnormal_eye_physiology0.72848420
31MP0001485_abnormal_pinna_reflex0.71417595
32MP0000762_abnormal_tongue_morphology0.70972034
33* MP0000367_abnormal_coat/_hair0.68821051
34MP0002177_abnormal_outer_ear0.67271703
35MP0003806_abnormal_nucleotide_metabolis0.66481664
36MP0002089_abnormal_postnatal_growth/wei0.65313926
37* MP0010094_abnormal_chromosome_stability0.65146039
38MP0000566_synostosis0.62730219
39MP0002092_abnormal_eye_morphology0.61371458
40MP0000733_abnormal_muscle_development0.54136387
41MP0003705_abnormal_hypodermis_morpholog0.53191140
42MP0003950_abnormal_plasma_membrane0.52408817
43MP0003646_muscle_fatigue0.51098414
44* MP0005391_vision/eye_phenotype0.48572210
45* MP0005551_abnormal_eye_electrophysiolog0.48296140
46MP0005193_abnormal_anterior_eye0.47968498
47MP0003943_abnormal_hepatobiliary_system0.47045317
48MP0005058_abnormal_lysosome_morphology0.45065554
49MP0001849_ear_inflammation0.44484635
50MP0010307_abnormal_tumor_latency0.42115586
51MP0000920_abnormal_myelination0.38486068
52* MP0002090_abnormal_vision0.37271803
53MP0010234_abnormal_vibrissa_follicle0.36312678
54MP0001984_abnormal_olfaction0.36217972
55MP0004233_abnormal_muscle_weight0.35541644
56MP0008007_abnormal_cellular_replicative0.35479527
57MP0002060_abnormal_skin_morphology0.34755611
58MP0000749_muscle_degeneration0.34132895
59MP0003634_abnormal_glial_cell0.33482489
60MP0006054_spinal_hemorrhage0.31742559
61* MP0005257_abnormal_intraocular_pressure0.31692763
62MP0002837_dystrophic_cardiac_calcinosis0.30804906
63MP0009840_abnormal_foam_cell0.30310820
64MP0005187_abnormal_penis_morphology0.30029004
65MP0008569_lethality_at_weaning0.28650868
66MP0004782_abnormal_surfactant_physiolog0.28362805
67* MP0000377_abnormal_hair_follicle0.27729459
68MP0000427_abnormal_hair_cycle0.27050448
69MP0000026_abnormal_inner_ear0.26490183
70MP0001851_eye_inflammation0.25465113
71MP0004272_abnormal_basement_membrane0.24856909
72MP0003566_abnormal_cell_adhesion0.24347453
73MP0002822_catalepsy0.23589734
74MP0009046_muscle_twitch0.23413859
75MP0006138_congestive_heart_failure0.23243550
76MP0001958_emphysema0.23224650
77MP0003077_abnormal_cell_cycle0.23061856
78MP0004924_abnormal_behavior0.22918750
79MP0005386_behavior/neurological_phenoty0.22918750
80MP0000681_abnormal_thyroid_gland0.22746904
81MP0002751_abnormal_autonomic_nervous0.22566721
82MP0003938_abnormal_ear_development0.21926082
83MP0001963_abnormal_hearing_physiology0.21687805
84MP0003567_abnormal_fetal_cardiomyocyte0.21234620
85MP0000647_abnormal_sebaceous_gland0.20856670
86MP0001915_intracranial_hemorrhage0.20529570
87MP0002697_abnormal_eye_size0.20506571
88MP0008877_abnormal_DNA_methylation0.20371632
89MP0005023_abnormal_wound_healing0.19932142
90MP0005670_abnormal_white_adipose0.19837885
91MP0003632_abnormal_nervous_system0.19776214
92MP0006292_abnormal_olfactory_placode0.19755629
93MP0003186_abnormal_redox_activity0.19197041
94MP0003787_abnormal_imprinting0.19063441
95MP0010678_abnormal_skin_adnexa0.18234663
96MP0003937_abnormal_limbs/digits/tail_de0.17855454
97MP0002233_abnormal_nose_morphology0.17073710
98MP0003385_abnormal_body_wall0.16420060
99MP0002998_abnormal_bone_remodeling0.15654846
100MP0002098_abnormal_vibrissa_morphology0.15087976
101MP0004808_abnormal_hematopoietic_stem0.14111770
102MP0000383_abnormal_hair_follicle0.13344054
103MP0002909_abnormal_adrenal_gland0.12672026
104MP0003786_premature_aging0.12649382
105MP0005621_abnormal_cell_physiology0.11635048
106MP0002269_muscular_atrophy0.11311467
107MP0004197_abnormal_fetal_growth/weight/0.11033688
108MP0008438_abnormal_cutaneous_collagen0.10698838
109MP0000579_abnormal_nail_morphology0.10189903
110MP0001188_hyperpigmentation0.09807375
111MP0000639_abnormal_adrenal_gland0.09412332
112MP0001299_abnormal_eye_distance/0.08826148
113MP0005623_abnormal_meninges_morphology0.08797448
114MP0003091_abnormal_cell_migration0.08542083
115MP0002009_preneoplasia0.08114321
116* MP0005195_abnormal_posterior_eye0.08042123
117MP0000465_gastrointestinal_hemorrhage0.08012136
118MP0001270_distended_abdomen0.07900565
119MP0010030_abnormal_orbit_morphology0.07575909
120MP0005503_abnormal_tendon_morphology0.07574424
121* MP0005384_cellular_phenotype0.07437007
122MP0005508_abnormal_skeleton_morphology0.07413075
123MP0002229_neurodegeneration0.07309092
124* MP0003111_abnormal_nucleus_morphology0.07229701
125MP0001919_abnormal_reproductive_system0.07053031
126MP0001286_abnormal_eye_development0.06851932
127MP0002557_abnormal_social/conspecific_i0.06433877
128MP0000534_abnormal_ureter_morphology0.06358975
129MP0008932_abnormal_embryonic_tissue0.06036269
130MP0000627_abnormal_mammary_gland0.05733278
131MP0005330_cardiomyopathy0.04768800
132MP0005164_abnormal_response_to0.04760830
133MP0009379_abnormal_foot_pigmentation0.04303265
134MP0000432_abnormal_head_morphology0.04080363
135* MP0002752_abnormal_somatic_nervous0.04035022
136* MP0008770_decreased_survivor_rate0.03575058
137MP0005379_endocrine/exocrine_gland_phen0.03512166
138MP0004484_altered_response_of0.02681846
139MP0004147_increased_porphyrin_level0.02596405
140MP0005275_abnormal_skin_tensile0.02413902
141MP0003698_abnormal_male_reproductive0.01904947

Predicted human phenotypes

RankGene SetZ-score
1* Hypoplasia of the fovea (HP:0007750)9.45332920
2* Aplasia/Hypoplasia of the fovea (HP:0008060)9.45332920
3* Ocular albinism (HP:0001107)9.11813911
4* Abnormality of the fovea (HP:0000493)8.43954498
5White forelock (HP:0002211)8.43847750
6* Iris hypopigmentation (HP:0007730)8.01859803
7Congenital sensorineural hearing impairment (HP:0008527)7.91758519
8Patchy hypopigmentation of hair (HP:0011365)7.62314329
9* Hypopigmentation of the fundus (HP:0007894)6.89287750
10Subacute progressive viral hepatitis (HP:0006572)6.50905913
11* Generalized hypopigmentation (HP:0007513)6.04744487
12Hypoplasia of the iris (HP:0007676)5.84183950
13Heterochromia iridis (HP:0001100)5.60872373
14Cutaneous melanoma (HP:0012056)4.98851948
15Premature graying of hair (HP:0002216)4.92317997
16Bilateral sensorineural hearing impairment (HP:0008619)4.79859882
17Albinism (HP:0001022)4.54144465
18Viral hepatitis (HP:0006562)3.68799794
19Spastic paraparesis (HP:0002313)3.67670803
20* Aplasia/Hypoplasia affecting the fundus (HP:0008057)3.60219097
21Peripheral hypomyelination (HP:0007182)3.59269964
22Micronodular cirrhosis (HP:0001413)3.49977630
23* Freckling (HP:0001480)3.45875030
24Decreased electroretinogram (ERG) amplitude (HP:0000654)3.13181625
25Melanoma (HP:0002861)3.09409678
26Hepatocellular carcinoma (HP:0001402)2.87014841
27Paraparesis (HP:0002385)2.80495820
28Abnormality of glycolipid metabolism (HP:0010969)2.75715763
29Abnormality of liposaccharide metabolism (HP:0010968)2.75715763
30Abnormality of glycosphingolipid metabolism (HP:0004343)2.75715763
31Decreased central vision (HP:0007663)2.68207383
32Cerebral hypomyelination (HP:0006808)2.54378709
33Abnormal auditory evoked potentials (HP:0006958)2.54117357
34Attenuation of retinal blood vessels (HP:0007843)2.49881077
35Vertebral compression fractures (HP:0002953)2.47967850
36J-shaped sella turcica (HP:0002680)2.22577393
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.16205669
38Underdeveloped nasal alae (HP:0000430)2.13138920
39Morphological abnormality of the inner ear (HP:0011390)2.12743210
40Chromsome breakage (HP:0040012)2.10416926
41Cerebral inclusion bodies (HP:0100314)2.07208127
42Amblyopia (HP:0000646)2.06253493
43Abnormal autonomic nervous system physiology (HP:0012332)2.03197389
44Synophrys (HP:0000664)2.02702433
45Abnormality of the renal collecting system (HP:0004742)2.01551405
46* Aplasia/Hypoplasia of the macula (HP:0008059)11.6396381
47* Aplasia/Hypoplasia affecting the retina (HP:0008061)10.7030249
48* Blue irides (HP:0000635)10.6330629
49Protrusio acetabuli (HP:0003179)1.92911264
50Keratoconus (HP:0000563)1.92272686
51Increased corneal curvature (HP:0100692)1.92272686
52Tented upper lip vermilion (HP:0010804)1.91190295
53Horizontal nystagmus (HP:0000666)1.89142236
54Decreased lacrimation (HP:0000633)1.86887375
55Duplicated collecting system (HP:0000081)1.81582236
56Rhabdomyosarcoma (HP:0002859)1.79532063
57Cerebral aneurysm (HP:0004944)1.78254382
58* Generalized hypopigmentation of hair (HP:0011358)1.77011710
59* Photophobia (HP:0000613)1.73181586
60Atelectasis (HP:0100750)1.73107720
61Scapular winging (HP:0003691)1.69607559
62Renal cell carcinoma (HP:0005584)1.68835389
63Asymmetric septal hypertrophy (HP:0001670)1.66249603
64Congenital stationary night blindness (HP:0007642)1.66001352
65Abnormality of the anterior horn cell (HP:0006802)1.65683080
66Degeneration of anterior horn cells (HP:0002398)1.65683080
67Loss of speech (HP:0002371)1.62887327
68Supernumerary ribs (HP:0005815)1.59718621
69Hypopigmented skin patches (HP:0001053)1.59112393
70Narrow nasal bridge (HP:0000446)1.57347354
71Hand muscle atrophy (HP:0009130)1.53435929
72Hepatitis (HP:0012115)1.53241805
73Myelomeningocele (HP:0002475)1.52586524
74Neurofibrillary tangles (HP:0002185)1.51860473
75Tracheomalacia (HP:0002779)1.51786659
76Supernumerary bones of the axial skeleton (HP:0009144)1.51490986
77Hypokinesia (HP:0002375)1.49056618
78Increased cerebral lipofuscin (HP:0011813)1.46350986
79Aplasia cutis congenita (HP:0001057)1.45830275
80Akinesia (HP:0002304)1.45072547
81Cutaneous finger syndactyly (HP:0010554)1.44593205
82Lip pit (HP:0100267)1.44214024
83Decreased motor nerve conduction velocity (HP:0003431)1.43482525
84Increased neuronal autofluorescent lipopigment (HP:0002074)1.43417635
85Mucopolysacchariduria (HP:0008155)1.42285824
86Urinary glycosaminoglycan excretion (HP:0003541)1.42285824
87Asymmetry of the thorax (HP:0001555)1.41785428
88Abnormality of mucopolysaccharide metabolism (HP:0011020)1.41280146
89Abnormality of polysaccharide metabolism (HP:0011012)1.41280146
90Abnormality of glycosaminoglycan metabolism (HP:0004371)1.41280146
91Neoplasm of the liver (HP:0002896)1.39619048
92Absent epiphyses (HP:0010577)1.38859787
93Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.38859787
94Morphological abnormality of the middle ear (HP:0008609)1.37490359
95Neoplasm of the oral cavity (HP:0100649)1.36228813
96Large for gestational age (HP:0001520)1.35849181
97Osteolytic defects of the hand bones (HP:0009699)1.35297821
98Osteolytic defects of the phalanges of the hand (HP:0009771)1.35297821
99Abnormality of the anterior chamber (HP:0000593)1.34637315
100Synostosis of carpal bones (HP:0005048)1.34514180
101Supernumerary nipples (HP:0002558)1.33081833
102Frequent falls (HP:0002359)1.32629782
103Adrenal hypoplasia (HP:0000835)1.27281451
104Tongue fasciculations (HP:0001308)1.26286530
105Carpal synostosis (HP:0009702)1.25866692
106CNS hypomyelination (HP:0003429)1.25679443
107Cutaneous syndactyly (HP:0012725)1.25235231
108Poor head control (HP:0002421)1.24988391
109Upper limb amyotrophy (HP:0009129)1.24650508
110Distal upper limb amyotrophy (HP:0007149)1.24650508
111Submucous cleft hard palate (HP:0000176)1.23716940
112Cholecystitis (HP:0001082)1.23051993
113Abnormal gallbladder physiology (HP:0012438)1.23051993
114Visual hallucinations (HP:0002367)1.22871276
115Abnormality of the salivary glands (HP:0010286)1.21405161
116Prolonged neonatal jaundice (HP:0006579)1.21310549
117Hypoplasia of the capital femoral epiphysis (HP:0003090)1.21055361
118Upper limb muscle weakness (HP:0003484)1.20735463
119Facial cleft (HP:0002006)1.19471070
120Cutaneous photosensitivity (HP:0000992)1.19311521
121Impaired proprioception (HP:0010831)1.16533641
122Dysostosis multiplex (HP:0000943)1.16313356
123Spastic paraplegia (HP:0001258)1.16256763
124Insidious onset (HP:0003587)1.16103106
125Termporal pattern (HP:0011008)1.16103106
126Aganglionic megacolon (HP:0002251)1.16053405
127Flared metaphyses (HP:0003015)1.14997230
128Ulnar claw (HP:0001178)1.14992298
129Diminished movement (HP:0002374)1.14676729
130Spinal muscular atrophy (HP:0007269)1.13469365
131Global brain atrophy (HP:0002283)1.13455662
132Deformed sella turcica (HP:0002681)1.12021401
133Constricted visual fields (HP:0001133)1.09155355
134Distal sensory impairment (HP:0002936)1.08361248
135Nasal speech (HP:0001611)1.07939128
136Abnormality of the distal phalanges of the toes (HP:0010182)1.07724244
137Peripheral demyelination (HP:0011096)1.07641356
138Intestinal polyposis (HP:0200008)1.06003429
139Ulnar bowing (HP:0003031)1.05936564
140Furrowed tongue (HP:0000221)1.05789509
141Supranuclear gaze palsy (HP:0000605)1.05733468
142Paraplegia (HP:0010550)1.05175007
143Abnormality of the nasal septum (HP:0000419)1.05163555
144Overlapping toe (HP:0001845)1.05064136
145Spastic diplegia (HP:0001264)1.03386963
146Stomach cancer (HP:0012126)1.02617834
147Synostosis involving bones of the hand (HP:0004278)1.01653520
148Abnormality of chromosome stability (HP:0003220)1.01229744
149Abnormality of the shoulder girdle musculature (HP:0001435)0.99996348
150Acrocyanosis (HP:0001063)0.99969750
151Neoplasm of striated muscle (HP:0009728)0.93100143
152Telecanthus (HP:0000506)0.92708928
153Coarse hair (HP:0002208)0.92284632
154Hypochromic microcytic anemia (HP:0004840)0.91755116
155Ulnar deviation of finger (HP:0009465)0.91276709
156Abnormality of the antihelix (HP:0009738)0.89458968
157Alacrima (HP:0000522)0.88879931
158Ectopic kidney (HP:0000086)0.88286686
159Sprengel anomaly (HP:0000912)0.88250255
160Corneal dystrophy (HP:0001131)0.87031650
161Ulnar deviation of the hand or of fingers of the hand (HP:0001193)0.86171996
162Hypothermia (HP:0002045)0.84227530
163Reticulocytopenia (HP:0001896)0.84086626

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MET5.41841888
2PDK24.28678632
3MARK34.22767360
4MAP3K33.71821501
5BMX3.60160183
6WEE13.28419789
7PRKD32.51916523
8MAP3K22.36139563
9PKN22.29775559
10EPHA32.16496074
11ICK2.05388940
12MST1R13.6467212
13CDK31.99214397
14ZAK1.72206393
15NME21.44518961
16MAPKAPK31.42513632
17TRIM281.32803608
18PRKCH1.28521901
19TYRO31.17695966
20PRKD11.15011617
21SIK31.06141877
22ABL20.90294670
23DDR20.89806108
24ERBB20.89703039
25LATS10.89085202
26FGFR10.88436335
27NUAK10.83225490
28SGK20.80554171
29LRRK20.77581615
30TRIB30.76238819
31IRAK30.74554863
32SCYL20.73080124
33PTK2B0.72205573
34EEF2K0.71811246
35GSK3A0.70301672
36CDK180.70154069
37FLT30.69255229
38CDK150.63616572
39MAP3K60.62197864
40PLK20.62024643
41TLK10.61978134
42PBK0.61385035
43TGFBR20.59615335
44IRAK40.58974425
45SRPK10.58777043
46CDK11A0.58430154
47MKNK20.58349038
48ACVR1B0.57443508
49PRKD20.56548095
50ERBB30.55986021
51NEK20.55738244
52FGFR40.55106951
53PRKCE0.54355032
54PLK30.54198796
55FRK0.53093346
56PAK60.52973159
57CSNK1G10.51617317
58MAPK110.50523170
59CDK140.49615124
60STK38L0.48255465
61CASK0.47375290
62CSNK1A1L0.47159014
63STK30.47016513
64CCNB10.46622052
65MAPK120.45898798
66PDGFRA0.45570878
67MKNK10.45506568
68PLK40.45258757
69CHEK20.44916881
70SGK30.44880769
71MAP2K10.44778219
72RPS6KA20.44704571
73MAP3K140.43611773
74RIPK10.43231222
75SGK2230.43004373
76SGK4940.43004373
77ZAP700.42515070
78EIF2AK30.42321194
79AKT30.41472144
80CSNK1G30.41429402
81DYRK1A0.41318894
82GRK50.41075961
83PTK20.40796996
84GRK60.39518775
85FGR0.39484917
86PTK60.39458239
87BRSK20.37792966
88MAPKAPK50.35683232
89STK40.35129392
90CAMKK10.34801193
91BCR0.34061452
92MATK0.33644338
93CSNK1D0.32735111
94PDPK10.31624266
95BLK0.31582395
96CDK70.31323289
97EIF2AK10.31010004
98PAK40.30760097
99CAMKK20.30459343
100FER0.30167751
101MAPK70.29930852
102TBK10.29268746
103ATR0.29113762
104TRPM70.28858256
105NEK10.28506173
106YES10.28025802
107AKT20.27968243
108CSNK1A10.27317268
109KIT0.27250371
110EIF2AK20.27134227
111FGFR20.26207786
112RPS6KB20.25504669
113CDC70.24323511
114ERBB40.24321329
115PRKG20.24108383
116VRK10.23937624
117TGFBR10.23375147
118MAP3K110.23225141
119PRKACB0.22670313
120NEK60.22471019
121PRKAA20.22229696
122PRKCZ0.21731465
123INSR0.21638670
124TYK20.21458894
125CSNK1G20.21323045
126KSR10.21251745
127TNIK0.20713067
128NEK90.20092385
129TTK0.19795315
130PDGFRB0.17734578
131STK160.17337022
132CDK60.17307088
133PRKCD0.16943557
134ABL10.16204769
135BUB10.16075478
136FGFR30.16053400
137BMPR1B0.15716044
138MTOR0.15558154
139ATM0.15551636
140LMTK20.15506172
141ILK0.15249268
142TXK0.15023606
143RPS6KA10.14556978
144PLK10.14264678
145BMPR20.14225360
146ADRBK10.14195661
147LYN0.14127302
148TTN0.13610218
149MAPK30.13584588
150BRSK10.12836753
151BRAF0.12548328
152MAP2K60.12547159
153MAP3K130.11839507
154RPS6KA50.11500475
155AURKA0.11174418
156IRAK10.10703869
157CHUK0.10090638
158AKT10.08614140
159CAMK2B0.08507309
160OBSCN0.07174602
161IGF1R0.06784742

Predicted pathways (KEGG)

RankGene SetZ-score
1* Tyrosine metabolism_Homo sapiens_hsa003507.82327615
2Glycosaminoglycan degradation_Homo sapiens_hsa005314.16526402
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.34499201
4* Melanogenesis_Homo sapiens_hsa049162.97458554
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.54277600
6Melanoma_Homo sapiens_hsa052182.28598834
7Galactose metabolism_Homo sapiens_hsa000522.16997825
8Fanconi anemia pathway_Homo sapiens_hsa034602.16701084
9One carbon pool by folate_Homo sapiens_hsa006702.06778233
10Collecting duct acid secretion_Homo sapiens_hsa049662.01364438
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.99529947
12Central carbon metabolism in cancer_Homo sapiens_hsa052301.95744098
13Fatty acid elongation_Homo sapiens_hsa000621.88056284
14Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.79975338
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.69696294
16Malaria_Homo sapiens_hsa051441.67618666
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66908313
18Systemic lupus erythematosus_Homo sapiens_hsa053221.64729902
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.64530406
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56654127
21Vibrio cholerae infection_Homo sapiens_hsa051101.56305294
22Renal cell carcinoma_Homo sapiens_hsa052111.53258512
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.51629447
24Adherens junction_Homo sapiens_hsa045201.47204857
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.42350124
26Thyroid cancer_Homo sapiens_hsa052161.39764885
27Retinol metabolism_Homo sapiens_hsa008301.39179562
28N-Glycan biosynthesis_Homo sapiens_hsa005101.30097733
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28640887
30Starch and sucrose metabolism_Homo sapiens_hsa005001.28437853
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22639229
32Linoleic acid metabolism_Homo sapiens_hsa005911.20396213
33Homologous recombination_Homo sapiens_hsa034401.16084988
34p53 signaling pathway_Homo sapiens_hsa041151.15003422
35Lysosome_Homo sapiens_hsa041421.14859546
36Lysine degradation_Homo sapiens_hsa003101.14347816
37Fructose and mannose metabolism_Homo sapiens_hsa000511.12160865
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07836792
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03776477
40DNA replication_Homo sapiens_hsa030301.03617617
41Phagosome_Homo sapiens_hsa041451.03169798
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01555340
43Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00282949
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00110333
45Steroid biosynthesis_Homo sapiens_hsa001000.99878997
46RNA degradation_Homo sapiens_hsa030180.98159243
47Carbon metabolism_Homo sapiens_hsa012000.97153062
48Phototransduction_Homo sapiens_hsa047440.96889192
49ABC transporters_Homo sapiens_hsa020100.94585074
50Non-homologous end-joining_Homo sapiens_hsa034500.92994031
51Alcoholism_Homo sapiens_hsa050340.91317570
52Glioma_Homo sapiens_hsa052140.90722958
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86608468
54Oocyte meiosis_Homo sapiens_hsa041140.86014345
55Non-small cell lung cancer_Homo sapiens_hsa052230.86009383
56Arachidonic acid metabolism_Homo sapiens_hsa005900.84795950
57HIF-1 signaling pathway_Homo sapiens_hsa040660.82834042
58Cell cycle_Homo sapiens_hsa041100.79757637
59MicroRNAs in cancer_Homo sapiens_hsa052060.79163856
60Pentose phosphate pathway_Homo sapiens_hsa000300.78666925
61Measles_Homo sapiens_hsa051620.77736562
62Sphingolipid metabolism_Homo sapiens_hsa006000.76669628
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74228998
64Axon guidance_Homo sapiens_hsa043600.73396259
65Ether lipid metabolism_Homo sapiens_hsa005650.73293424
66Vitamin digestion and absorption_Homo sapiens_hsa049770.71903278
67Prostate cancer_Homo sapiens_hsa052150.71270311
68Colorectal cancer_Homo sapiens_hsa052100.70891048
69Inositol phosphate metabolism_Homo sapiens_hsa005620.70014284
70mTOR signaling pathway_Homo sapiens_hsa041500.70011217
71Nitrogen metabolism_Homo sapiens_hsa009100.69989390
72Mismatch repair_Homo sapiens_hsa034300.69251633
73Nucleotide excision repair_Homo sapiens_hsa034200.69163798
74Histidine metabolism_Homo sapiens_hsa003400.68751805
75Other glycan degradation_Homo sapiens_hsa005110.68623639
76Alzheimers disease_Homo sapiens_hsa050100.68417224
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.68219817
78Propanoate metabolism_Homo sapiens_hsa006400.67082734
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66290284
80Small cell lung cancer_Homo sapiens_hsa052220.66267338
81Rheumatoid arthritis_Homo sapiens_hsa053230.66231390
82Viral carcinogenesis_Homo sapiens_hsa052030.66132119
83Protein export_Homo sapiens_hsa030600.65927932
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63356619
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62172382
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60448084
87Proteasome_Homo sapiens_hsa030500.59965483
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59715629
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59469020
90Sulfur relay system_Homo sapiens_hsa041220.59411666
91RNA polymerase_Homo sapiens_hsa030200.59239446
92Folate biosynthesis_Homo sapiens_hsa007900.58664130
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56966808
94Glutathione metabolism_Homo sapiens_hsa004800.56690552
95Pyruvate metabolism_Homo sapiens_hsa006200.56172110
96Endocytosis_Homo sapiens_hsa041440.55670194
97Mineral absorption_Homo sapiens_hsa049780.51445981
98Autoimmune thyroid disease_Homo sapiens_hsa053200.51159810
99Base excision repair_Homo sapiens_hsa034100.51033411
100beta-Alanine metabolism_Homo sapiens_hsa004100.50730096
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48432163
102Phenylalanine metabolism_Homo sapiens_hsa003600.47992214
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47071512
104Ras signaling pathway_Homo sapiens_hsa040140.45545128
105Proteoglycans in cancer_Homo sapiens_hsa052050.45274679
106Insulin signaling pathway_Homo sapiens_hsa049100.43157072
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43127360
108Basal transcription factors_Homo sapiens_hsa030220.43097988
109ECM-receptor interaction_Homo sapiens_hsa045120.42838237
110Epstein-Barr virus infection_Homo sapiens_hsa051690.42794350
111Fatty acid metabolism_Homo sapiens_hsa012120.42708393
112Hepatitis B_Homo sapiens_hsa051610.42517011
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42400589
114Osteoclast differentiation_Homo sapiens_hsa043800.42332376
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41853899
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40792810
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39654244
118Graft-versus-host disease_Homo sapiens_hsa053320.37712017
119Spliceosome_Homo sapiens_hsa030400.36862658
120Oxidative phosphorylation_Homo sapiens_hsa001900.36261969
121Dorso-ventral axis formation_Homo sapiens_hsa043200.34057120
122Biosynthesis of amino acids_Homo sapiens_hsa012300.33664363
123* Metabolic pathways_Homo sapiens_hsa011000.32572372
124Parkinsons disease_Homo sapiens_hsa050120.32208320
125Pathways in cancer_Homo sapiens_hsa052000.31745257
126Herpes simplex infection_Homo sapiens_hsa051680.31692731
127Synaptic vesicle cycle_Homo sapiens_hsa047210.31274238
128Arginine and proline metabolism_Homo sapiens_hsa003300.31120161
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.29311771
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28973029
131Type I diabetes mellitus_Homo sapiens_hsa049400.28525647
132Insulin resistance_Homo sapiens_hsa049310.26640613
133Focal adhesion_Homo sapiens_hsa045100.26331143
134Chronic myeloid leukemia_Homo sapiens_hsa052200.26210861
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25989723
136Olfactory transduction_Homo sapiens_hsa047400.25713571
137Tuberculosis_Homo sapiens_hsa051520.25571073
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.25562759
139Intestinal immune network for IgA production_Homo sapiens_hsa046720.25231257
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24493327
141RNA transport_Homo sapiens_hsa030130.24352132
142Circadian rhythm_Homo sapiens_hsa047100.23392328
143Apoptosis_Homo sapiens_hsa042100.23039381
144Purine metabolism_Homo sapiens_hsa002300.23022291
145NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22986725
146FoxO signaling pathway_Homo sapiens_hsa040680.22500427
147Endometrial cancer_Homo sapiens_hsa052130.21572353
148Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.21061376
149ErbB signaling pathway_Homo sapiens_hsa040120.21026198

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »