TYRO3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.39998214
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.39226280
3locomotory exploration behavior (GO:0035641)5.17869914
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.99245104
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.86684729
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.67375285
7glutamate secretion (GO:0014047)4.61658470
8gonadal mesoderm development (GO:0007506)4.31504030
9layer formation in cerebral cortex (GO:0021819)4.30671610
10postsynaptic membrane organization (GO:0001941)4.29328157
11synaptic vesicle exocytosis (GO:0016079)4.28746144
12vocalization behavior (GO:0071625)4.14599359
13regulation of synaptic vesicle exocytosis (GO:2000300)4.09373757
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.08251053
15negative regulation of synaptic transmission, GABAergic (GO:0032229)4.01917170
16regulation of neuronal synaptic plasticity (GO:0048168)3.95644083
17dendritic spine morphogenesis (GO:0060997)3.89702660
18regulation of long-term neuronal synaptic plasticity (GO:0048169)3.89242638
19proline transport (GO:0015824)3.84750154
20neuronal action potential propagation (GO:0019227)3.82012196
21regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.74996697
22regulation of glutamate receptor signaling pathway (GO:1900449)3.71568475
23neuromuscular process controlling balance (GO:0050885)3.71091622
24synaptic transmission, glutamatergic (GO:0035249)3.69201718
25neurotransmitter secretion (GO:0007269)3.67138418
26regulation of synapse structural plasticity (GO:0051823)3.66563645
27presynaptic membrane assembly (GO:0097105)3.53701323
28ionotropic glutamate receptor signaling pathway (GO:0035235)3.53611819
29exploration behavior (GO:0035640)3.51571203
30regulation of synaptic vesicle transport (GO:1902803)3.50743251
31regulation of dendritic spine morphogenesis (GO:0061001)3.50597932
32protein localization to synapse (GO:0035418)3.50196271
33sodium ion export (GO:0071436)3.48899466
34cellular potassium ion homeostasis (GO:0030007)3.48516349
35presynaptic membrane organization (GO:0097090)3.44418546
36positive regulation of synapse maturation (GO:0090129)3.44382588
37neuron-neuron synaptic transmission (GO:0007270)3.40752654
38auditory behavior (GO:0031223)3.39260870
39cytoskeletal anchoring at plasma membrane (GO:0007016)3.32503201
40regulation of posttranscriptional gene silencing (GO:0060147)3.31804598
41regulation of gene silencing by miRNA (GO:0060964)3.31804598
42regulation of gene silencing by RNA (GO:0060966)3.31804598
43long-term memory (GO:0007616)3.29754500
44cerebellar granule cell differentiation (GO:0021707)3.28294226
45transmission of nerve impulse (GO:0019226)3.27969508
46neuronal ion channel clustering (GO:0045161)3.24100353
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.23650170
48behavioral response to nicotine (GO:0035095)3.18252234
49positive regulation of dendritic spine development (GO:0060999)3.17366326
50serotonin metabolic process (GO:0042428)3.16898508
51gamma-aminobutyric acid transport (GO:0015812)3.16537380
52maintenance of protein location in nucleus (GO:0051457)3.14996749
53glycine transport (GO:0015816)3.14738672
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.14660649
55positive regulation of membrane potential (GO:0045838)3.14301668
56regulation of synaptic plasticity (GO:0048167)3.14282403
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.13041824
58prepulse inhibition (GO:0060134)3.12488878
59dendritic spine organization (GO:0097061)3.08827936
60positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.07677852
61amino acid import (GO:0043090)3.07547080
62glutamate receptor signaling pathway (GO:0007215)3.05802335
63primary amino compound metabolic process (GO:1901160)3.03258682
64potassium ion import (GO:0010107)3.01180519
65neurotransmitter transport (GO:0006836)3.00607868
66neuromuscular process controlling posture (GO:0050884)3.00410770
67regulation of postsynaptic membrane potential (GO:0060078)2.96170357
68membrane depolarization during action potential (GO:0086010)2.95955539
69L-amino acid import (GO:0043092)2.95145226
70positive regulation of dendritic spine morphogenesis (GO:0061003)2.92902343
71axon ensheathment in central nervous system (GO:0032291)2.92570611
72central nervous system myelination (GO:0022010)2.92570611
73histone H4-K5 acetylation (GO:0043981)2.91895482
74histone H4-K8 acetylation (GO:0043982)2.91895482
75positive regulation of neurotransmitter transport (GO:0051590)2.91526944
76neuromuscular synaptic transmission (GO:0007274)2.91298265
77positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.90982999
78regulation of synapse maturation (GO:0090128)2.90339273
79establishment of nucleus localization (GO:0040023)2.89774609
80G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.89375320
81regulation of voltage-gated calcium channel activity (GO:1901385)2.88725952
82neuron cell-cell adhesion (GO:0007158)2.88239603
83neurotransmitter-gated ion channel clustering (GO:0072578)2.87492071
84membrane hyperpolarization (GO:0060081)2.84890852
85negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.83019089
86neurotransmitter uptake (GO:0001504)2.82791713
87response to auditory stimulus (GO:0010996)2.82712505
88activation of protein kinase A activity (GO:0034199)2.81769042
89synaptic vesicle endocytosis (GO:0048488)2.80683750
90cell migration in hindbrain (GO:0021535)2.80323331
91behavioral fear response (GO:0001662)2.79776570
92behavioral defense response (GO:0002209)2.79776570
93chemosensory behavior (GO:0007635)2.78099670
94regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.77668610
95neuromuscular process (GO:0050905)2.76948982
96regulation of neurotransmitter secretion (GO:0046928)2.74895518
97cerebellar Purkinje cell differentiation (GO:0021702)2.74502955
98membrane depolarization (GO:0051899)2.72468060
99C4-dicarboxylate transport (GO:0015740)2.71402754
100gamma-aminobutyric acid signaling pathway (GO:0007214)2.70672382
101adult walking behavior (GO:0007628)2.70238330
102regulation of neurotransmitter levels (GO:0001505)2.70063919
103long-term synaptic potentiation (GO:0060291)2.69985155
104regulation of dendritic spine development (GO:0060998)2.69301188
105histone H4-K12 acetylation (GO:0043983)2.68788350
106regulation of synaptic transmission, glutamatergic (GO:0051966)2.68489786
107adenosine receptor signaling pathway (GO:0001973)2.64998079
108positive regulation of neurotransmitter secretion (GO:0001956)2.63362008
109vesicle transport along microtubule (GO:0047496)2.63054058
110behavioral response to cocaine (GO:0048148)2.62216341
111mating behavior (GO:0007617)2.61784762
112regulation of neurotransmitter transport (GO:0051588)2.61527741
113dendrite morphogenesis (GO:0048813)2.60590494
114regulation of response to osmotic stress (GO:0047484)2.60548080
115startle response (GO:0001964)2.59765363
116myelination (GO:0042552)2.59699882
117response to dietary excess (GO:0002021)2.59084777
118ensheathment of neurons (GO:0007272)2.58942510
119axon ensheathment (GO:0008366)2.58942510
120detection of temperature stimulus (GO:0016048)2.58902048
121potassium ion homeostasis (GO:0055075)2.57544020
122cochlea development (GO:0090102)2.57323218
123striatum development (GO:0021756)2.57094017
124synaptic transmission (GO:0007268)2.55786500
125positive regulation of dendrite development (GO:1900006)2.55702091
126synaptic transmission, dopaminergic (GO:0001963)2.55123913
127fear response (GO:0042596)2.54909021
128negative regulation of amino acid transport (GO:0051956)2.54564271
129neuron recognition (GO:0008038)2.52806465
130cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.51441764
131regulation of neurotransmitter uptake (GO:0051580)2.50468060
132acidic amino acid transport (GO:0015800)2.48792325
133cell communication by electrical coupling (GO:0010644)2.48699567
134regulation of calcium ion-dependent exocytosis (GO:0017158)2.47844390
135cellular potassium ion transport (GO:0071804)2.44845756
136potassium ion transmembrane transport (GO:0071805)2.44845756
137innervation (GO:0060384)2.43694748
138detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.42560198

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.48500218
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.12198342
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.12198342
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.12198342
5* RARB_27405468_Chip-Seq_BRAIN_Mouse3.11685229
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.02735547
7IKZF1_21737484_ChIP-ChIP_HCT116_Human2.55948957
8SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.55526730
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53218214
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53218214
11ERG_21242973_ChIP-ChIP_JURKAT_Human2.46095135
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.43530508
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42985623
14ZFP281_18757296_ChIP-ChIP_E14_Mouse2.39690697
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.34513087
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.29515786
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.24890156
18REST_21632747_ChIP-Seq_MESCs_Mouse2.23443866
19DROSHA_22980978_ChIP-Seq_HELA_Human2.20129276
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.17811341
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.10273506
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06610899
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.01998307
24* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.99562795
25* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.98796206
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97875762
27* KDM2B_26808549_Chip-Seq_K562_Human1.97168514
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.96242104
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.94291832
30NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.93625601
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92312225
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88759427
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88374724
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.82886492
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82374119
36SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.74020190
37RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.73319555
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69412321
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67264789
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65061626
41RING1B_27294783_Chip-Seq_NPCs_Mouse1.60302224
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58452806
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58157338
44ZNF274_21170338_ChIP-Seq_K562_Hela1.57123924
45SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.56827680
46EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.55216893
47* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.54146373
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.54035212
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52639512
50AR_21572438_ChIP-Seq_LNCaP_Human1.49715598
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48946541
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.46323508
53* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.45434602
54* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43483888
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41689909
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41663906
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41165850
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39946695
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.39698252
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38266275
61VDR_22108803_ChIP-Seq_LS180_Human1.38230015
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36384247
63CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36007749
64* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35170569
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35036687
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.33088411
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31322569
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31322569
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30701905
70P300_19829295_ChIP-Seq_ESCs_Human1.26477209
71GBX2_23144817_ChIP-Seq_PC3_Human1.24330038
72TAF15_26573619_Chip-Seq_HEK293_Human1.22287018
73TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.22197971
74PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.21944317
75SMC4_20622854_ChIP-Seq_HELA_Human1.20997814
76ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20863353
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.19184163
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.18445175
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.17582693
80* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.16286811
81* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.16203554
82DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15946271
83TET1_21490601_ChIP-Seq_MESCs_Mouse1.15856593
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13938880
85SMAD3_21741376_ChIP-Seq_ESCs_Human1.13246916
86* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.10644236
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10235713
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.09378748
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09087809
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08548581
91AR_19668381_ChIP-Seq_PC3_Human1.07257550
92KDM2B_26808549_Chip-Seq_DND41_Human1.07219605
93LXR_22292898_ChIP-Seq_THP-1_Human1.07004403
94TP53_20018659_ChIP-ChIP_R1E_Mouse1.06887939
95OCT4_19829295_ChIP-Seq_ESCs_Human1.05732515
96CREB1_26743006_Chip-Seq_LNCaP_Human1.05619353
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05394944
98* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04976135
99RNF2_27304074_Chip-Seq_NSC_Mouse1.04893708
100* CTCF_27219007_Chip-Seq_Bcells_Human1.03344491
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02343950
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.01964823
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01958615
104E2F1_17053090_ChIP-ChIP_MCF-7_Human1.01770227
105* SMAD3_21741376_ChIP-Seq_HESCs_Human1.00807046
106FUS_26573619_Chip-Seq_HEK293_Human1.00303576
107P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99859652
108SMAD4_21799915_ChIP-Seq_A2780_Human0.99824488
109TCF4_23295773_ChIP-Seq_U87_Human0.97333930
110IGF1R_20145208_ChIP-Seq_DFB_Human0.97311024
111NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97068894
112OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96822906
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96584389
114POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96403460
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96240123
116STAT3_23295773_ChIP-Seq_U87_Human0.96024844
117TP53_22127205_ChIP-Seq_IMR90_Human0.95633357
118* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.95467999
119THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94992892
120SOX9_26525672_Chip-Seq_HEART_Mouse0.93562005
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93171329
122* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92123668
123KDM2B_26808549_Chip-Seq_JURKAT_Human0.91893990
124TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90857699
125AHR_22903824_ChIP-Seq_MCF-7_Human0.89647983
126* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.89395531
127KLF4_19829295_ChIP-Seq_ESCs_Human0.89286896
128PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88859457
129CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88724772
130* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.88492456
131MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87834140
132NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87648128
133LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87580747
134SOX2_21211035_ChIP-Seq_LN229_Gbm0.87496623
135FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87246356
136PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86719409
137SOX2_16153702_ChIP-ChIP_HESCs_Human0.86603114
138* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.85107100
139SMAD4_21741376_ChIP-Seq_HESCs_Human0.84118467
140CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83644952
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83453450
142KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.83332094
143RACK7_27058665_Chip-Seq_MCF-7_Human0.83139685
144MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82999596
145RUNX2_22187159_ChIP-Seq_PCA_Human0.82497063
146DPY_21335234_ChIP-Seq_ESCs_Mouse0.81923124
147SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81770031
148* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.81633527
149LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81433882
150KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81296950
151* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.81063215
152* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.80514453
153UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.80201570

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.85626246
2MP0003635_abnormal_synaptic_transmissio3.45502521
3MP0002822_catalepsy3.41932022
4MP0004270_analgesia3.40437913
5MP0003880_abnormal_central_pattern3.20298983
6MP0004858_abnormal_nervous_system3.11771591
7MP0003136_yellow_coat_color2.82017303
8MP0009046_muscle_twitch2.81650571
9MP0002063_abnormal_learning/memory/cond2.81374914
10MP0009745_abnormal_behavioral_response2.73243359
11* MP0002064_seizures2.60335409
12MP0001486_abnormal_startle_reflex2.54325033
13MP0002572_abnormal_emotion/affect_behav2.43840802
14MP0002272_abnormal_nervous_system2.36983850
15MP0005394_taste/olfaction_phenotype2.08993033
16MP0005499_abnormal_olfactory_system2.08993033
17MP0002734_abnormal_mechanical_nocicepti2.03403397
18MP0004885_abnormal_endolymph2.00369051
19MP0002653_abnormal_ependyma_morphology1.90284269
20MP0005623_abnormal_meninges_morphology1.89208432
21MP0000566_synostosis1.87610294
22MP0005423_abnormal_somatic_nervous1.84569397
23MP0003283_abnormal_digestive_organ1.83368328
24MP0001440_abnormal_grooming_behavior1.73731839
25MP0008877_abnormal_DNA_methylation1.69783353
26MP0003329_amyloid_beta_deposits1.66972106
27MP0000955_abnormal_spinal_cord1.64083845
28MP0003122_maternal_imprinting1.63491649
29MP0008569_lethality_at_weaning1.62395326
30MP0000778_abnormal_nervous_system1.62222324
31MP0001968_abnormal_touch/_nociception1.61043929
32MP0002733_abnormal_thermal_nociception1.58914814
33MP0004811_abnormal_neuron_physiology1.53550374
34MP0001970_abnormal_pain_threshold1.51123230
35MP0005551_abnormal_eye_electrophysiolog1.49277753
36MP0006276_abnormal_autonomic_nervous1.48366538
37MP0001501_abnormal_sleep_pattern1.44670485
38MP0002184_abnormal_innervation1.42183182
39MP0009379_abnormal_foot_pigmentation1.39887179
40MP0000920_abnormal_myelination1.39156191
41MP0008961_abnormal_basal_metabolism1.37139321
42MP0003890_abnormal_embryonic-extraembry1.36960747
43MP0002882_abnormal_neuron_morphology1.35438155
44MP0009780_abnormal_chondrocyte_physiolo1.33991614
45MP0002557_abnormal_social/conspecific_i1.33723897
46MP0002067_abnormal_sensory_capabilities1.31752898
47MP0002909_abnormal_adrenal_gland1.31341445
48MP0003787_abnormal_imprinting1.29301237
49MP0003632_abnormal_nervous_system1.29206609
50MP0002938_white_spotting1.29027240
51MP0002254_reproductive_system_inflammat1.26422976
52MP0004264_abnormal_extraembryonic_tissu1.23687700
53MP0001984_abnormal_olfaction1.21954117
54MP0002066_abnormal_motor_capabilities/c1.21886049
55MP0003879_abnormal_hair_cell1.21028619
56MP0005386_behavior/neurological_phenoty1.19880744
57MP0004924_abnormal_behavior1.19880744
58MP0006292_abnormal_olfactory_placode1.19433052
59MP0004043_abnormal_pH_regulation1.19165430
60MP0002638_abnormal_pupillary_reflex1.17785277
61MP0001502_abnormal_circadian_rhythm1.16265646
62MP0002152_abnormal_brain_morphology1.13727871
63MP0003634_abnormal_glial_cell1.13585621
64MP0003690_abnormal_glial_cell1.12164813
65MP0005171_absent_coat_pigmentation1.10918170
66MP0004142_abnormal_muscle_tone1.08238544
67MP0004147_increased_porphyrin_level1.07982616
68MP0001299_abnormal_eye_distance/1.07717752
69MP0003633_abnormal_nervous_system1.05912824
70MP0001293_anophthalmia1.04311004
71MP0003631_nervous_system_phenotype1.04259244
72MP0008872_abnormal_physiological_respon1.03840792
73MP0010234_abnormal_vibrissa_follicle1.00779235
74MP0003121_genomic_imprinting1.00658284
75MP0003123_paternal_imprinting0.99261856
76MP0003938_abnormal_ear_development0.99121592
77MP0001485_abnormal_pinna_reflex0.98738254
78MP0003861_abnormal_nervous_system0.97817043
79MP0003119_abnormal_digestive_system0.95503098
80MP0002229_neurodegeneration0.92843796
81MP0002736_abnormal_nociception_after0.92808124
82MP0000579_abnormal_nail_morphology0.90408220
83MP0004145_abnormal_muscle_electrophysio0.89389555
84MP0001188_hyperpigmentation0.87978198
85MP0005167_abnormal_blood-brain_barrier0.87717982
86MP0000026_abnormal_inner_ear0.87589536
87MP0001346_abnormal_lacrimal_gland0.87552200
88MP0000631_abnormal_neuroendocrine_gland0.87282606
89MP0003937_abnormal_limbs/digits/tail_de0.87093507
90MP0004742_abnormal_vestibular_system0.86685632
91MP0003878_abnormal_ear_physiology0.85186737
92MP0005377_hearing/vestibular/ear_phenot0.85186737
93MP0001529_abnormal_vocalization0.83989361
94MP0002752_abnormal_somatic_nervous0.83116619
95MP0004133_heterotaxia0.82949656
96MP0002876_abnormal_thyroid_physiology0.82368262
97MP0005410_abnormal_fertilization0.81594302
98MP0000569_abnormal_digit_pigmentation0.81275328
99MP0001849_ear_inflammation0.80815819
100MP0005174_abnormal_tail_pigmentation0.80157540
101MP0003705_abnormal_hypodermis_morpholog0.79469785
102MP0001177_atelectasis0.79140463
103MP0003137_abnormal_impulse_conducting0.79076051
104MP0006072_abnormal_retinal_apoptosis0.77305622
105MP0003075_altered_response_to0.76900192
106MP0004130_abnormal_muscle_cell0.76199517
107MP0000049_abnormal_middle_ear0.76051844
108MP0010678_abnormal_skin_adnexa0.75594631
109MP0002089_abnormal_postnatal_growth/wei0.74963515
110MP0000534_abnormal_ureter_morphology0.74630614
111MP0008995_early_reproductive_senescence0.74001580
112MP0002735_abnormal_chemical_nociception0.73933702
113MP0001905_abnormal_dopamine_level0.73800869
114MP0005253_abnormal_eye_physiology0.73681287
115MP0009672_abnormal_birth_weight0.73627165
116MP0005645_abnormal_hypothalamus_physiol0.72037565
117MP0002234_abnormal_pharynx_morphology0.71701280
118MP0010030_abnormal_orbit_morphology0.71391464
119MP0001963_abnormal_hearing_physiology0.70997012
120MP0008874_decreased_physiological_sensi0.69594254
121MP0005646_abnormal_pituitary_gland0.69527243
122MP0002160_abnormal_reproductive_system0.69255357
123MP0003045_fibrosis0.68385893
124MP0001986_abnormal_taste_sensitivity0.67961234
125MP0000762_abnormal_tongue_morphology0.67260618
126MP0004085_abnormal_heartbeat0.66730274
127MP0002233_abnormal_nose_morphology0.65975364
128MP0001348_abnormal_lacrimal_gland0.65538662
129MP0002090_abnormal_vision0.64703852
130MP0002332_abnormal_exercise_endurance0.63670825
131MP0002069_abnormal_eating/drinking_beha0.63657293

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.80222367
2Abnormality of the lower motor neuron (HP:0002366)4.87208735
3Focal motor seizures (HP:0011153)4.27428535
4Focal seizures (HP:0007359)4.11964978
5Bilateral microphthalmos (HP:0007633)3.65793294
6Ankle clonus (HP:0011448)3.64547613
7Epileptic encephalopathy (HP:0200134)3.39128460
8Action tremor (HP:0002345)3.20433789
9Visual hallucinations (HP:0002367)3.12264728
10Atonic seizures (HP:0010819)3.07170120
11Annular pancreas (HP:0001734)3.00239875
12Amblyopia (HP:0000646)2.96094807
13Amyotrophic lateral sclerosis (HP:0007354)2.89664792
14Abnormality of the corticospinal tract (HP:0002492)2.85394847
15Febrile seizures (HP:0002373)2.83527845
16Resting tremor (HP:0002322)2.79908460
17Intention tremor (HP:0002080)2.73562061
18Ependymoma (HP:0002888)2.73477687
19Generalized tonic-clonic seizures (HP:0002069)2.72280827
20Distal upper limb amyotrophy (HP:0007149)2.64023526
21Upper limb amyotrophy (HP:0009129)2.64023526
22Dysdiadochokinesis (HP:0002075)2.63377462
23Supranuclear gaze palsy (HP:0000605)2.61923799
24Astrocytoma (HP:0009592)2.60901219
25Abnormality of the astrocytes (HP:0100707)2.60901219
26Dialeptic seizures (HP:0011146)2.60899656
27Hemiparesis (HP:0001269)2.57014138
28Hepatoblastoma (HP:0002884)2.52956703
29Spastic gait (HP:0002064)2.52757158
30Dysmetria (HP:0001310)2.48974864
31Limb dystonia (HP:0002451)2.48468888
32Bronchomalacia (HP:0002780)2.47270872
33Diplopia (HP:0000651)2.47173460
34Abnormality of binocular vision (HP:0011514)2.47173460
35Neoplasm of the heart (HP:0100544)2.44530093
36Depression (HP:0000716)2.42640357
37Absence seizures (HP:0002121)2.40064445
38Progressive cerebellar ataxia (HP:0002073)2.35635372
39Septo-optic dysplasia (HP:0100842)2.34654275
40Tetraplegia (HP:0002445)2.34037863
41Ankyloglossia (HP:0010296)2.32869413
42Gaze-evoked nystagmus (HP:0000640)2.28358869
43Hand muscle atrophy (HP:0009130)2.27570135
44Urinary bladder sphincter dysfunction (HP:0002839)2.25266577
45Abnormality of the labia minora (HP:0012880)2.23998198
46Generalized hypotonia (HP:0001290)2.23943574
47Male infertility (HP:0003251)2.23637820
48Spastic tetraparesis (HP:0001285)2.21747744
49Scanning speech (HP:0002168)2.21667546
50Pointed chin (HP:0000307)2.19583271
51Clonus (HP:0002169)2.19157644
52Rib fusion (HP:0000902)2.18852481
53Achilles tendon contracture (HP:0001771)2.18541861
54Impaired vibration sensation in the lower limbs (HP:0002166)2.17993129
55Sensory axonal neuropathy (HP:0003390)2.17320907
56Dysphonia (HP:0001618)2.16931734
57Poor eye contact (HP:0000817)2.15781186
58Urinary urgency (HP:0000012)2.14832344
59Anophthalmia (HP:0000528)2.14787930
60Abnormal eating behavior (HP:0100738)2.13747405
61Type II lissencephaly (HP:0007260)2.12711397
62Hyperventilation (HP:0002883)2.11987628
63Horizontal nystagmus (HP:0000666)2.10588536
64Renal duplication (HP:0000075)2.10343563
65Torticollis (HP:0000473)2.09003283
66Neurofibrillary tangles (HP:0002185)2.08092961
67Genetic anticipation (HP:0003743)2.07074932
68Insomnia (HP:0100785)2.06231760
69Neoplasm of striated muscle (HP:0009728)2.03571277
70Optic nerve hypoplasia (HP:0000609)2.02913437
71Cerebral inclusion bodies (HP:0100314)2.02668661
72Megalencephaly (HP:0001355)2.02388471
73Abnormal social behavior (HP:0012433)2.01832493
74Impaired social interactions (HP:0000735)2.01832493
75Postural instability (HP:0002172)2.00710959
76Abnormality of the salivary glands (HP:0010286)2.00676535
77Lower limb muscle weakness (HP:0007340)1.98711242
78Birth length less than 3rd percentile (HP:0003561)1.98699655
79Morphological abnormality of the inner ear (HP:0011390)1.98412856
80Inability to walk (HP:0002540)1.97792974
81Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.96878325
82Congenital stationary night blindness (HP:0007642)1.96665657
83Cerebellar dysplasia (HP:0007033)1.96480926
84Abnormality of the musculature of the hand (HP:0001421)1.96186331
85Drooling (HP:0002307)1.94815411
86Broad-based gait (HP:0002136)1.94422626
87Molar tooth sign on MRI (HP:0002419)1.94396798
88Abnormality of midbrain morphology (HP:0002418)1.94396798
89Epileptiform EEG discharges (HP:0011182)1.92413312
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92363281
91Abnormality of ocular smooth pursuit (HP:0000617)1.91814354
92Neuronal loss in central nervous system (HP:0002529)1.90975294
93Preaxial foot polydactyly (HP:0001841)1.90909541
94Gonadal dysgenesis (HP:0000133)1.89895515
95Abnormality of the diencephalon (HP:0010662)1.89294931
96Status epilepticus (HP:0002133)1.88923415
97Partial duplication of thumb phalanx (HP:0009944)1.88783633
98Cutaneous finger syndactyly (HP:0010554)1.87620677
99Turricephaly (HP:0000262)1.87581793
100Glioma (HP:0009733)1.86308079
101Relative macrocephaly (HP:0004482)1.84959813
102Morphological abnormality of the pyramidal tract (HP:0002062)1.84792725
103Coronal craniosynostosis (HP:0004440)1.84100655
104Aplasia involving bones of the upper limbs (HP:0009823)1.83687512
105Aplasia of the phalanges of the hand (HP:0009802)1.83687512
106Aplasia involving bones of the extremities (HP:0009825)1.83687512
107Abnormality of the Achilles tendon (HP:0005109)1.83675618
108Hemiplegia (HP:0002301)1.83308929
109Protruding tongue (HP:0010808)1.83052334
110Difficulty running (HP:0009046)1.83007598
111Split foot (HP:0001839)1.82412251
112Cerebral hypomyelination (HP:0006808)1.81884077
113Hyperalaninemia (HP:0003348)1.81216208
114Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81216208
115Abnormality of alanine metabolism (HP:0010916)1.81216208
116Pancreatic cysts (HP:0001737)1.80944446
117Pancreatic fibrosis (HP:0100732)1.80033555
118Insidious onset (HP:0003587)1.79497549
119Termporal pattern (HP:0011008)1.79497549
120CNS hypomyelination (HP:0003429)1.79395062
121True hermaphroditism (HP:0010459)1.79192296
122Apathy (HP:0000741)1.78686803
123Hypopigmentation of the fundus (HP:0007894)1.78407526
124Focal dystonia (HP:0004373)1.78174569
125Clumsiness (HP:0002312)1.76370185
126Abnormality of cochlea (HP:0000375)1.76200177
127Sleep apnea (HP:0010535)1.75282377
128Impaired smooth pursuit (HP:0007772)1.75260593
129Hyperglycinuria (HP:0003108)1.75054320
130Onion bulb formation (HP:0003383)1.74045111
131Cutaneous syndactyly (HP:0012725)1.73629766
132Hypochromic microcytic anemia (HP:0004840)1.73408470
133Impaired vibratory sensation (HP:0002495)1.72054448
134Abnormal auditory evoked potentials (HP:0006958)1.71601351
135Bradykinesia (HP:0002067)1.71436116
136Malignant neoplasm of the central nervous system (HP:0100836)1.70820037
137EEG with generalized epileptiform discharges (HP:0011198)1.68997551
138Confusion (HP:0001289)1.68864347
139Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.66875932
140Degeneration of the lateral corticospinal tracts (HP:0002314)1.66875932
141Partial agenesis of the corpus callosum (HP:0001338)1.66459659
142Hypsarrhythmia (HP:0002521)1.65467079
143Maternal diabetes (HP:0009800)1.65021734
144Sclerocornea (HP:0000647)1.64423182
145Partial duplication of the phalanx of hand (HP:0009999)1.64105273
146Choanal stenosis (HP:0000452)1.63426924
147Esophageal atresia (HP:0002032)1.63226481
148Overriding aorta (HP:0002623)1.62828728
149Generalized myoclonic seizures (HP:0002123)1.62763472
150Broad metatarsal (HP:0001783)1.62259997
151Stereotypic behavior (HP:0000733)1.62250182
152Gait imbalance (HP:0002141)1.62165641
153Excessive salivation (HP:0003781)1.60873274
154Colon cancer (HP:0003003)1.59146077
155Nephronophthisis (HP:0000090)1.56469542
156Retinal dysplasia (HP:0007973)1.54388970

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.42143208
2MAP3K93.62607385
3CDK123.50081290
4NTRK33.08263070
5PRKD32.86332735
6GRK52.77281820
7DAPK22.73102004
8CASK2.63213560
9NTRK12.47965611
10PAK62.42681912
11KSR22.24295099
12WNK11.97574392
13MAP3K41.89489297
14FRK1.82127954
15MINK11.78926697
16WNK41.73280193
17PRPF4B1.70585286
18ZAK1.68170462
19NTRK21.67093023
20MARK11.60105410
21MAP2K41.50745891
22CAMKK11.49537441
23ALK1.45109912
24CAMK1D1.45071705
25MAPK131.44956458
26CDK191.43791836
27RIPK11.41823255
28CAMK1G1.40724935
29STK381.36619365
30BMPR1B1.34022581
31ICK1.33579362
32CDK51.28717344
33MARK21.28667545
34LATS21.23898513
35KSR11.23878279
36TAOK11.23821058
37DYRK21.20673394
38SIK21.19927257
39DAPK11.16301637
40UHMK11.12257165
41GRK61.11213867
42OXSR11.06337762
43CDK151.05578306
44* TYRO31.05515140
45ADRBK21.04505708
46MAPK71.02795873
47CDK181.01048591
48INSRR0.99755718
49MOS0.98816289
50WNK30.96021584
51CAMKK20.94807904
52CDK140.94476818
53CDK11A0.94369351
54CAMK40.93914586
55PKN10.93521533
56STK390.92896568
57MAP3K20.92614557
58PRKCG0.89036715
59MKNK20.88424639
60TIE10.88209110
61TLK10.87900869
62DDR20.87248428
63PAK30.86222259
64BRSK10.85880644
65WEE10.84715793
66STK110.80801462
67MATK0.80456770
68PLK30.78711496
69ARAF0.78318784
70SGK4940.76312796
71SGK2230.76312796
72PRKCH0.75690973
73CDC70.74872480
74BMX0.74783543
75MAP2K70.74213019
76RIPK40.73383028
77TTK0.71176567
78MAPKAPK50.71139015
79PDGFRA0.70870142
80TSSK60.70684847
81PNCK0.65881263
82CAMK10.63842752
83PRKCE0.62786565
84NEK10.61965270
85MAPK100.59243434
86PDK10.59113110
87PLK40.59034367
88TNK20.58180339
89MAP3K130.57812466
90SGK20.57058729
91LMTK20.56781146
92MAP3K70.55375547
93DAPK30.55215798
94CAMK2B0.55012946
95DYRK1A0.54635964
96PDPK10.54370567
97FGFR20.54331996
98PLK20.53134970
99PHKG10.52962013
100PHKG20.52962013
101MKNK10.52898678
102NEK60.52839473
103LIMK10.52831251
104GRK10.52243003
105RPS6KA30.51369141
106TRIB30.51356133
107RET0.51092563
108CDC42BPA0.50466851
109RAF10.50168339
110MAP4K20.50161374
111TNIK0.49075300
112PINK10.49054145
113PRKCZ0.48980152
114CAMK2A0.47359643
115CSNK1E0.47349885
116CAMK2G0.46482692
117CHEK20.46040963
118CSNK1D0.44767373
119SGK30.44470913
120ERN10.44097745
121ROCK20.43713530
122PTK20.43645871
123CSNK1G10.43631364
124STK38L0.43416804
125PRKD20.42381870
126PLK10.41583230
127CSNK1G20.41360070
128CSNK1A10.41308048
129PAK40.41075036
130SGK10.40549517
131ERBB20.39882959
132FYN0.39561001
133PRKDC0.37964918
134PTK2B0.37781228
135FGFR10.37663885
136DMPK0.37471963
137GSK3B0.37370827
138ADRBK10.37087467
139PRKACA0.36593286
140PRKAA10.36115939
141ACVR1B0.35804837

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.73583279
2Olfactory transduction_Homo sapiens_hsa047402.68529014
3Nicotine addiction_Homo sapiens_hsa050332.64477498
4Glutamatergic synapse_Homo sapiens_hsa047242.49771065
5Long-term potentiation_Homo sapiens_hsa047202.47568244
6GABAergic synapse_Homo sapiens_hsa047272.44220404
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.35991329
8Circadian entrainment_Homo sapiens_hsa047132.27229785
9Morphine addiction_Homo sapiens_hsa050322.13211850
10Amphetamine addiction_Homo sapiens_hsa050312.11624859
11Salivary secretion_Homo sapiens_hsa049702.05471833
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.03733447
13Dopaminergic synapse_Homo sapiens_hsa047281.93316017
14Gastric acid secretion_Homo sapiens_hsa049711.88689265
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.76355855
16Long-term depression_Homo sapiens_hsa047301.73600026
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71727906
18Phototransduction_Homo sapiens_hsa047441.65829243
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63682147
20Cholinergic synapse_Homo sapiens_hsa047251.63559547
21Oxytocin signaling pathway_Homo sapiens_hsa049211.63007252
22Nitrogen metabolism_Homo sapiens_hsa009101.57568989
23Renin secretion_Homo sapiens_hsa049241.53367905
24Cocaine addiction_Homo sapiens_hsa050301.52213335
25Insulin secretion_Homo sapiens_hsa049111.51375092
26GnRH signaling pathway_Homo sapiens_hsa049121.49090129
27Axon guidance_Homo sapiens_hsa043601.47861865
28Gap junction_Homo sapiens_hsa045401.43952735
29Taste transduction_Homo sapiens_hsa047421.42734575
30Calcium signaling pathway_Homo sapiens_hsa040201.40433206
31cAMP signaling pathway_Homo sapiens_hsa040241.40195386
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.38929266
33Vitamin B6 metabolism_Homo sapiens_hsa007501.38152844
34Phospholipase D signaling pathway_Homo sapiens_hsa040721.35579703
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34745483
36Serotonergic synapse_Homo sapiens_hsa047261.33729283
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32532464
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29770251
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22958972
40Dorso-ventral axis formation_Homo sapiens_hsa043201.21155966
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18967537
42ErbB signaling pathway_Homo sapiens_hsa040121.15967862
43Glioma_Homo sapiens_hsa052141.15114677
44Estrogen signaling pathway_Homo sapiens_hsa049151.14394055
45Oocyte meiosis_Homo sapiens_hsa041141.13003279
46Melanogenesis_Homo sapiens_hsa049161.11279555
47Vascular smooth muscle contraction_Homo sapiens_hsa042701.09281036
48mTOR signaling pathway_Homo sapiens_hsa041501.08015773
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04333326
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03073412
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01051105
52Hedgehog signaling pathway_Homo sapiens_hsa043401.00949461
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00591548
54Oxidative phosphorylation_Homo sapiens_hsa001900.98963331
55Choline metabolism in cancer_Homo sapiens_hsa052310.96638508
56Tight junction_Homo sapiens_hsa045300.93891096
57beta-Alanine metabolism_Homo sapiens_hsa004100.93061729
58Rap1 signaling pathway_Homo sapiens_hsa040150.92644179
59Sulfur relay system_Homo sapiens_hsa041220.92483171
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92112357
61Arginine and proline metabolism_Homo sapiens_hsa003300.91173409
62Selenocompound metabolism_Homo sapiens_hsa004500.89843087
63VEGF signaling pathway_Homo sapiens_hsa043700.89101858
64Butanoate metabolism_Homo sapiens_hsa006500.88317670
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85474358
66Inositol phosphate metabolism_Homo sapiens_hsa005620.83413961
67Histidine metabolism_Homo sapiens_hsa003400.83290054
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82749250
69Hippo signaling pathway_Homo sapiens_hsa043900.82438808
70Ovarian steroidogenesis_Homo sapiens_hsa049130.81444134
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79561666
72Type II diabetes mellitus_Homo sapiens_hsa049300.79097024
73Parkinsons disease_Homo sapiens_hsa050120.77354851
74Linoleic acid metabolism_Homo sapiens_hsa005910.76707157
75Alzheimers disease_Homo sapiens_hsa050100.76679902
76Wnt signaling pathway_Homo sapiens_hsa043100.76492143
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.75687540
78Endocytosis_Homo sapiens_hsa041440.75519201
79Non-small cell lung cancer_Homo sapiens_hsa052230.74055537
80MAPK signaling pathway_Homo sapiens_hsa040100.72968390
81RNA polymerase_Homo sapiens_hsa030200.71052868
82Ras signaling pathway_Homo sapiens_hsa040140.70589319
83Dilated cardiomyopathy_Homo sapiens_hsa054140.70503671
84Ribosome_Homo sapiens_hsa030100.70126616
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.69030031
86Pancreatic secretion_Homo sapiens_hsa049720.68352946
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67477039
88Thyroid hormone synthesis_Homo sapiens_hsa049180.67475518
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65861589
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64411194
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64356295
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63396284
93Renal cell carcinoma_Homo sapiens_hsa052110.63297380
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62583981
95Huntingtons disease_Homo sapiens_hsa050160.61733803
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60314871
97One carbon pool by folate_Homo sapiens_hsa006700.59425644
98Fructose and mannose metabolism_Homo sapiens_hsa000510.58014851
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57735748
100Alcoholism_Homo sapiens_hsa050340.57619631
101Collecting duct acid secretion_Homo sapiens_hsa049660.57367224
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.56190210
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56130361
104Basal cell carcinoma_Homo sapiens_hsa052170.56005820
105Endometrial cancer_Homo sapiens_hsa052130.54533878
106Tryptophan metabolism_Homo sapiens_hsa003800.54380709
107Fatty acid biosynthesis_Homo sapiens_hsa000610.54365356
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54177963
109Folate biosynthesis_Homo sapiens_hsa007900.54033409
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53154374
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52530936
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52037039
113Propanoate metabolism_Homo sapiens_hsa006400.51768010
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51537989
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.51084286
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49834902
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.49509353
118Cardiac muscle contraction_Homo sapiens_hsa042600.49032298
119Proteoglycans in cancer_Homo sapiens_hsa052050.48832897
120Homologous recombination_Homo sapiens_hsa034400.48498641
121Pyruvate metabolism_Homo sapiens_hsa006200.48395682
122Bile secretion_Homo sapiens_hsa049760.47119433
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46945339
124Glycerolipid metabolism_Homo sapiens_hsa005610.46538594
125Fanconi anemia pathway_Homo sapiens_hsa034600.46132426
126Fatty acid metabolism_Homo sapiens_hsa012120.44117943
127Vibrio cholerae infection_Homo sapiens_hsa051100.43538806
128Steroid biosynthesis_Homo sapiens_hsa001000.43053932
129Arginine biosynthesis_Homo sapiens_hsa002200.42302862
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.41112904
131Glucagon signaling pathway_Homo sapiens_hsa049220.40940281
132ABC transporters_Homo sapiens_hsa020100.40479241
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40422249
134mRNA surveillance pathway_Homo sapiens_hsa030150.40392005
135Prion diseases_Homo sapiens_hsa050200.39563026
136Ether lipid metabolism_Homo sapiens_hsa005650.39087177
137Thyroid cancer_Homo sapiens_hsa052160.38397489
138Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36195681

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