TYRO3P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ethanol (GO:0071361)5.42668318
2nuclear pore complex assembly (GO:0051292)5.27289805
3positive regulation of transcription from RNA polymerase III promoter (GO:0045945)5.27019880
4nuclear pore organization (GO:0006999)4.40890104
5replicative senescence (GO:0090399)4.38572381
6interkinetic nuclear migration (GO:0022027)4.20623166
7monoubiquitinated protein deubiquitination (GO:0035520)4.16587936
8cytoplasmic mRNA processing body assembly (GO:0033962)4.12740829
9corticosteroid receptor signaling pathway (GO:0031958)4.08424590
10glucocorticoid receptor signaling pathway (GO:0042921)4.07849752
11histone H3-K4 trimethylation (GO:0080182)4.01626816
12negative regulation of cell cycle G2/M phase transition (GO:1902750)4.01427506
13regulation of RNA export from nucleus (GO:0046831)3.92828801
14mitotic sister chromatid cohesion (GO:0007064)3.78329471
15regulation of hippo signaling (GO:0035330)3.78070860
16definitive hemopoiesis (GO:0060216)3.77116121
17snRNA transcription (GO:0009301)3.73368803
18pore complex assembly (GO:0046931)3.72513010
19protein K48-linked deubiquitination (GO:0071108)3.71873752
20peptidyl-lysine methylation (GO:0018022)3.65425817
21positive regulation of developmental pigmentation (GO:0048087)3.61285671
22negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.59360231
23histone H3-K36 demethylation (GO:0070544)3.57211230
24embryonic process involved in female pregnancy (GO:0060136)3.53471431
25pre-miRNA processing (GO:0031054)3.51789639
26regulation of nucleobase-containing compound transport (GO:0032239)3.51623668
27negative regulation of histone methylation (GO:0031061)3.48639455
28pericardium development (GO:0060039)3.48619399
29regulation of histone H3-K27 methylation (GO:0061085)3.45561547
30leukotriene biosynthetic process (GO:0019370)3.45315122
31TOR signaling (GO:0031929)3.37381448
32dosage compensation (GO:0007549)3.32857159
33negative regulation of DNA repair (GO:0045738)3.26384994
34positive regulation by host of viral transcription (GO:0043923)3.23413084
35phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.22885662
36histone H3-K4 methylation (GO:0051568)3.22686792
37peptidyl-lysine dimethylation (GO:0018027)3.21227405
38sister chromatid cohesion (GO:0007062)3.18902381
39regulation of interleukin-12 biosynthetic process (GO:0045075)3.18672452
40peptidyl-lysine trimethylation (GO:0018023)3.14464233
41mitotic sister chromatid segregation (GO:0000070)3.11352079
42DNA duplex unwinding (GO:0032508)3.10315446
43mitotic chromosome condensation (GO:0007076)3.08257276
44regulation of NFAT protein import into nucleus (GO:0051532)3.05505903
45histone-serine phosphorylation (GO:0035404)3.05454685
46sister chromatid segregation (GO:0000819)3.02889012
47DNA geometric change (GO:0032392)3.01574891
48histone lysine methylation (GO:0034968)3.01496036
49regulation of DNA damage checkpoint (GO:2000001)2.99630324
50phospholipid translocation (GO:0045332)2.99541300
51lipid translocation (GO:0034204)2.99541300
52DNA synthesis involved in DNA repair (GO:0000731)2.91788095
53protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.91693732
54atrioventricular valve morphogenesis (GO:0003181)2.91199539
55N-terminal protein amino acid acetylation (GO:0006474)2.89901756
56regulation of DNA endoreduplication (GO:0032875)2.86784623
57negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.86562608
58negative regulation of translation, ncRNA-mediated (GO:0040033)2.86562608
59regulation of translation, ncRNA-mediated (GO:0045974)2.86562608
60DNA replication initiation (GO:0006270)2.86208865
61positive regulation of protein import into nucleus, translocation (GO:0033160)2.85473675
62regulation of cell proliferation involved in kidney development (GO:1901722)2.85004369
63regulation of pigment cell differentiation (GO:0050932)2.84502576
64regulation of establishment of cell polarity (GO:2000114)2.83340043
65embryonic camera-type eye morphogenesis (GO:0048596)2.78974857
66negative regulation of sodium ion transport (GO:0010766)2.78909378
67histone lysine demethylation (GO:0070076)2.70598539
68histone H3-K9 methylation (GO:0051567)2.70126678
69DNA replication checkpoint (GO:0000076)2.66891831
70histone phosphorylation (GO:0016572)2.66581153
71rRNA catabolic process (GO:0016075)2.63996241
72peptidyl-threonine dephosphorylation (GO:0035970)2.57978748
73histone demethylation (GO:0016577)2.57246631
74regulation of centrosome cycle (GO:0046605)2.56641923
75coronary vasculature morphogenesis (GO:0060977)2.55675920
76histone H3-K9 modification (GO:0061647)2.53671911
77protein K11-linked deubiquitination (GO:0035871)2.53160096
78regulation of fatty acid beta-oxidation (GO:0031998)2.52880118
79negative regulation of histone modification (GO:0031057)2.50294841
80regulation of histone H3-K9 methylation (GO:0051570)2.49792909
81nuclear envelope disassembly (GO:0051081)2.49595664
82membrane disassembly (GO:0030397)2.49595664
83regulation of centrosome duplication (GO:0010824)2.49578398
84protein K63-linked deubiquitination (GO:0070536)2.49434667
85mRNA cleavage (GO:0006379)2.48912564
86negative regulation of myotube differentiation (GO:0010832)2.48903721
87regulation of centriole replication (GO:0046599)2.48859800
88dorsal/ventral axis specification (GO:0009950)2.48299989
89DNA damage induced protein phosphorylation (GO:0006975)2.48262816
90histone H4-K16 acetylation (GO:0043984)2.47635111
91negative regulation of gene expression, epigenetic (GO:0045814)2.47454186
92fibroblast migration (GO:0010761)2.47237525
93DNA conformation change (GO:0071103)2.46925504
94mitotic nuclear envelope disassembly (GO:0007077)2.46238841
95positive regulation of CREB transcription factor activity (GO:0032793)2.41258678
96spleen development (GO:0048536)2.41006535
97meiotic chromosome segregation (GO:0045132)2.40136674
98cytoskeleton-dependent cytokinesis (GO:0061640)2.38626045
99regulation of necroptotic process (GO:0060544)2.38205057
100hepatocyte apoptotic process (GO:0097284)2.36392515

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.08651723
2E2F7_22180533_ChIP-Seq_HELA_Human7.08417325
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.58803003
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.30259057
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.63887828
6NOTCH1_21737748_ChIP-Seq_TLL_Human3.20426648
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.93384530
8MYC_22102868_ChIP-Seq_BL_Human2.60998321
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.54637401
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.52474618
11TP53_16413492_ChIP-PET_HCT116_Human2.43872298
12SCL_19346495_ChIP-Seq_HPC-7_Human2.40032231
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.22877840
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.17753305
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.17004981
16GATA1_22025678_ChIP-Seq_K562_Human2.10983792
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.10515811
18PKCTHETA_26484144_Chip-Seq_BREAST_Human2.07488611
19AHR_22903824_ChIP-Seq_MCF-7_Human1.88217636
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.87644657
21VDR_21846776_ChIP-Seq_THP-1_Human1.86203315
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.81078628
23TCF7_22412390_ChIP-Seq_EML_Mouse1.75998615
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.72690986
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72302438
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.72224864
27NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.70784846
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.70739268
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.69774380
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66180201
31CTNNB1_20460455_ChIP-Seq_HCT116_Human1.65007317
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58631142
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.56646647
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56489343
35ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52485710
36MYB_26560356_Chip-Seq_TH1_Human1.51186703
37GATA1_19941826_ChIP-Seq_K562_Human1.47651146
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46578702
39AR_21572438_ChIP-Seq_LNCaP_Human1.44702040
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.43668322
41FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.42504513
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41705031
43RUNX_20019798_ChIP-Seq_JUKART_Human1.38298091
44SOX9_24532713_ChIP-Seq_HFSC_Mouse1.35554734
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.35100866
46* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34779621
47* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34779621
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.33984010
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33485819
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32645574
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.29833065
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29627779
53VDR_24763502_ChIP-Seq_THP-1_Human1.26708577
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26550491
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.26219367
56GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25475730
57RXR_22108803_ChIP-Seq_LS180_Human1.21827598
58GATA2_19941826_ChIP-Seq_K562_Human1.20623216
59STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20370511
60CIITA_25753668_ChIP-Seq_RAJI_Human1.19777673
61TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13840513
62MAF_26560356_Chip-Seq_TH1_Human1.13536652
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12837066
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11002309
65DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10708683
66KDM5A_27292631_Chip-Seq_BREAST_Human1.09770771
67GATA6_25053715_ChIP-Seq_YYC3_Human1.08730944
68FOXA2_19822575_ChIP-Seq_HepG2_Human1.08703363
69MYB_26560356_Chip-Seq_TH2_Human1.07713282
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.07622372
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07420824
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05677168
73KDM2B_26808549_Chip-Seq_DND41_Human1.04776011
74SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03812505
75FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02506265
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02341474
77FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01868548
78BRD4_25478319_ChIP-Seq_HGPS_Human1.01758844
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01143151
80AR_21909140_ChIP-Seq_LNCAP_Human1.00862202
81UBF1/2_26484160_Chip-Seq_HMECs_Human0.99667024
82NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94397385
83SALL1_21062744_ChIP-ChIP_HESCs_Human0.94060550
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93238211
85CHD1_26751641_Chip-Seq_LNCaP_Human0.93038958
86FOXO3_23340844_ChIP-Seq_DLD1_Human0.92470945
87AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91523606
88SPI1_23127762_ChIP-Seq_K562_Human0.91348114
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89152761
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89152761
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86772664
92KDM2B_26808549_Chip-Seq_JURKAT_Human0.86056159
93GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84472675
94PPAR_26484153_Chip-Seq_NCI-H1993_Human0.82577315
95STAT3_23295773_ChIP-Seq_U87_Human0.82345402
96IRF8_22096565_ChIP-ChIP_GC-B_Human0.82146712
97ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81933100
98* UTX_26944678_Chip-Seq_JUKART_Human0.78975538
99Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78131372
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.76799210

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.04128039
2MP0000569_abnormal_digit_pigmentation5.29213651
3MP0005076_abnormal_cell_differentiation4.14379806
4MP0002396_abnormal_hematopoietic_system3.42589603
5MP0010094_abnormal_chromosome_stability3.09126769
6MP0002009_preneoplasia2.78605772
7MP0005083_abnormal_biliary_tract2.74799856
8MP0003705_abnormal_hypodermis_morpholog2.43104853
9MP0004808_abnormal_hematopoietic_stem2.35009690
10MP0004233_abnormal_muscle_weight2.28359927
11MP0003111_abnormal_nucleus_morphology2.24772777
12MP0003763_abnormal_thymus_physiology2.09194461
13MP0010352_gastrointestinal_tract_polyps2.00855484
14MP0010307_abnormal_tumor_latency1.92695190
15MP0002089_abnormal_postnatal_growth/wei1.84365287
16MP0000383_abnormal_hair_follicle1.82441403
17MP0003077_abnormal_cell_cycle1.81946080
18MP0000371_diluted_coat_color1.80556180
19MP0009697_abnormal_copulation1.75057615
20MP0000015_abnormal_ear_pigmentation1.69575458
21MP0002332_abnormal_exercise_endurance1.66527458
22MP0009115_abnormal_fat_cell1.63182308
23MP0003091_abnormal_cell_migration1.62947887
24MP0008961_abnormal_basal_metabolism1.54638847
25MP0006292_abnormal_olfactory_placode1.50589726
26MP0005310_abnormal_salivary_gland1.46637265
27MP0003786_premature_aging1.45091424
28MP0004185_abnormal_adipocyte_glucose1.39339868
29MP0010678_abnormal_skin_adnexa1.37971153
30MP0003984_embryonic_growth_retardation1.37195144
31MP0004130_abnormal_muscle_cell1.36911777
32MP0002970_abnormal_white_adipose1.35735873
33MP0003828_pulmonary_edema1.35682063
34MP0005220_abnormal_exocrine_pancreas1.33263724
35MP0002088_abnormal_embryonic_growth/wei1.30416768
36MP0001879_abnormal_lymphatic_vessel1.28470927
37MP0009840_abnormal_foam_cell1.21133409
38MP0002086_abnormal_extraembryonic_tissu1.19776009
39MP0002075_abnormal_coat/hair_pigmentati1.18642526
40MP0003045_fibrosis1.16902891
41MP0000427_abnormal_hair_cycle1.15946112
42MP0009278_abnormal_bone_marrow1.15418163
43MP0001873_stomach_inflammation1.13552144
44MP0005174_abnormal_tail_pigmentation1.12508019
45MP0005187_abnormal_penis_morphology1.11733808
46MP0000733_abnormal_muscle_development1.11324872
47MP0003959_abnormal_lean_body1.07895171
48MP0005397_hematopoietic_system_phenotyp1.06775047
49MP0001545_abnormal_hematopoietic_system1.06775047
50MP0002108_abnormal_muscle_morphology1.05364421
51MP0002166_altered_tumor_susceptibility1.05018784
52MP0005409_darkened_coat_color1.04451287
53MP0001672_abnormal_embryogenesis/_devel1.03896355
54MP0005380_embryogenesis_phenotype1.03896355
55MP0002938_white_spotting1.03260895
56MP0002398_abnormal_bone_marrow1.01155502
57MP0004381_abnormal_hair_follicle1.00487133
58MP0005621_abnormal_cell_physiology0.98789399
59MP0000350_abnormal_cell_proliferation0.98771281
60MP0000537_abnormal_urethra_morphology0.98477575
61MP0000703_abnormal_thymus_morphology0.98203342
62MP0005266_abnormal_metabolism0.95249375
63MP0003252_abnormal_bile_duct0.93464260
64MP0005408_hypopigmentation0.92605073
65MP0002168_other_aberrant_phenotype0.92555837
66MP0008932_abnormal_embryonic_tissue0.92484545
67MP0002796_impaired_skin_barrier0.92443315
68MP0002019_abnormal_tumor_incidence0.91606820
69MP0001186_pigmentation_phenotype0.89875473
70MP0005451_abnormal_body_composition0.87718412
71MP0002006_tumorigenesis0.86071520
72MP0005334_abnormal_fat_pad0.85701417
73MP0003646_muscle_fatigue0.85272945
74MP0004957_abnormal_blastocyst_morpholog0.84906853
75MP0000428_abnormal_craniofacial_morphol0.84562453
76MP0003656_abnormal_erythrocyte_physiolo0.83110773
77MP0001730_embryonic_growth_arrest0.81627356
78MP0000003_abnormal_adipose_tissue0.80498808
79MP0003890_abnormal_embryonic-extraembry0.80449946
80MP0002971_abnormal_brown_adipose0.79926985
81MP0002405_respiratory_system_inflammati0.79294167
82MP0008007_abnormal_cellular_replicative0.78527329
83MP0001697_abnormal_embryo_size0.78140146
84MP0004197_abnormal_fetal_growth/weight/0.77755502
85MP0002928_abnormal_bile_duct0.77666580
86MP0003693_abnormal_embryo_hatching0.76005054
87MP0002080_prenatal_lethality0.75445197
88MP0010368_abnormal_lymphatic_system0.74656777
89MP0002098_abnormal_vibrissa_morphology0.74426505
90MP0004947_skin_inflammation0.73558976
91MP0001661_extended_life_span0.71609865
92MP0001191_abnormal_skin_condition0.71519160
93MP0000689_abnormal_spleen_morphology0.71415721
94MP0008058_abnormal_DNA_repair0.69496299
95MP0002925_abnormal_cardiovascular_devel0.69455532
96MP0002722_abnormal_immune_system0.68948059
97MP0001784_abnormal_fluid_regulation0.68822810
98MP0003632_abnormal_nervous_system0.68467735
99MP0005384_cellular_phenotype0.67697584
100MP0001800_abnormal_humoral_immune0.67137376

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)5.17876443
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.76568418
3Clumsiness (HP:0002312)3.63105473
4Dysmetric saccades (HP:0000641)3.53526054
5Chromsome breakage (HP:0040012)3.49149152
6Abnormality of the nasal septum (HP:0000419)3.43500173
7Progressive muscle weakness (HP:0003323)3.35774740
8Long eyelashes (HP:0000527)3.19679266
9Lip pit (HP:0100267)3.18089255
10Urethral obstruction (HP:0000796)3.10442711
11Genetic anticipation (HP:0003743)3.08702108
12Prominent nose (HP:0000448)3.06088580
13Sparse lateral eyebrow (HP:0005338)2.97789791
14Abnormality of the distal phalanx of the thumb (HP:0009617)2.96615475
15Broad face (HP:0000283)2.96289192
16Narrow palate (HP:0000189)2.78392572
17Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.70319373
18Clubbing of toes (HP:0100760)2.69303018
19Heterotopia (HP:0002282)2.65809594
20Acute myeloid leukemia (HP:0004808)2.64927258
21Persistence of primary teeth (HP:0006335)2.62175096
22Sensory axonal neuropathy (HP:0003390)2.56952401
23Ectopic kidney (HP:0000086)2.56622571
24Abnormality of chromosome stability (HP:0003220)2.55603417
25Abnormality of the phalanges of the hallux (HP:0010057)2.51870792
26Sandal gap (HP:0001852)2.51285693
27Vertebral arch anomaly (HP:0008438)2.49600816
28Abnormality of the columella (HP:0009929)2.48323313
29Fair hair (HP:0002286)2.46919410
30Dislocated radial head (HP:0003083)2.45686826
31Protruding tongue (HP:0010808)2.44783574
32Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.40384975
33Duplicated collecting system (HP:0000081)2.40280092
34Truncal obesity (HP:0001956)2.38179231
35Abnormality of DNA repair (HP:0003254)2.37582473
36Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.36081020
37Short 4th metacarpal (HP:0010044)2.36081020
38IgA deficiency (HP:0002720)2.35599331
39Hypergonadotropic hypogonadism (HP:0000815)2.33407596
40Colitis (HP:0002583)2.28051812
41Abnormality of the radial head (HP:0003995)2.22069445
42Submucous cleft hard palate (HP:0000176)2.21290592
43Abnormality of the labia majora (HP:0012881)2.20610262
44Increased neuronal autofluorescent lipopigment (HP:0002074)2.15802395
45Fatigue (HP:0012378)2.13019478
46Birth length less than 3rd percentile (HP:0003561)2.06517882
47Short thumb (HP:0009778)2.06191721
48Progressive external ophthalmoplegia (HP:0000590)2.05392815
49Aplasia of the musculature (HP:0100854)2.04357553
50Abnormality of the renal collecting system (HP:0004742)2.04306005
51Progressive inability to walk (HP:0002505)2.04140980
52Capillary hemangiomas (HP:0005306)2.03484435
53Neonatal hypoglycemia (HP:0001998)2.03078892
54Wide intermamillary distance (HP:0006610)2.00130067
55Natal tooth (HP:0000695)1.99939526
56Deep philtrum (HP:0002002)1.97980172
57Anal stenosis (HP:0002025)1.97637876
58Thick eyebrow (HP:0000574)1.96132823
59Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.96032894
60Laryngomalacia (HP:0001601)1.95459820
61Generalized hypopigmentation of hair (HP:0011358)1.94776330
62Aplasia/Hypoplasia of the uvula (HP:0010293)1.94456620
63Abnormality of the sella turcica (HP:0002679)1.92923616
64Acute lymphatic leukemia (HP:0006721)1.91528515
65Low anterior hairline (HP:0000294)1.89793330
66Thoracolumbar scoliosis (HP:0002944)1.89577983
67Premature ovarian failure (HP:0008209)1.88663769
68Tented upper lip vermilion (HP:0010804)1.88249096
69Increased number of teeth (HP:0011069)1.87714957
70Spondylolisthesis (HP:0003302)1.86339828
71Flat acetabular roof (HP:0003180)1.86234082
72Slow saccadic eye movements (HP:0000514)1.85078605
73Long clavicles (HP:0000890)1.79228954
74Septate vagina (HP:0001153)1.79091829
75Hamartoma (HP:0010566)1.78338213
76Hypoplastic labia majora (HP:0000059)1.78146389
77Diastasis recti (HP:0001540)1.77860604
78Abnormality of the epiphyses of the hand (HP:0005924)1.77720588
79Underdeveloped nasal alae (HP:0000430)1.77050266
80Breast hypoplasia (HP:0003187)1.76315561
81Depressed nasal tip (HP:0000437)1.76145170
82Hypoplastic iliac wings (HP:0002866)1.76143554
83Ragged-red muscle fibers (HP:0003200)1.76111423
84Widely spaced teeth (HP:0000687)1.74915558
85Microtia (HP:0008551)1.74840837
86Milia (HP:0001056)1.73539127
87Abnormality of cochlea (HP:0000375)1.73288716
88Ureteral obstruction (HP:0006000)1.73249235
89Syringomyelia (HP:0003396)1.72971880
90Spinal cord lesions (HP:0100561)1.72971880
912-3 toe syndactyly (HP:0004691)1.72270539
92Gaze-evoked nystagmus (HP:0000640)1.71745073
93Hypoplasia of the pons (HP:0012110)1.71485379
94Increased cerebral lipofuscin (HP:0011813)1.70988450
95Squamous cell carcinoma (HP:0002860)1.70727660
96Smooth philtrum (HP:0000319)1.70478586
97Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.70262450
98Abnormal number of incisors (HP:0011064)1.67711020
99Deformed sella turcica (HP:0002681)1.67547872
100Short chin (HP:0000331)1.67259056

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.40752690
2ICK3.93625955
3AKT33.68627194
4EEF2K3.49696048
5PIM23.34517356
6TRIB32.61121511
7FRK2.57581420
8BRD42.55078536
9CAMK1D2.46857337
10ACVR1B2.45334830
11MAPK112.24686170
12CAMK1G2.13564435
13RAF12.04644553
14MELK1.93138095
15TRPM71.84095988
16MTOR1.80686044
17MAP3K71.79646876
18DYRK31.72022205
19BLK1.62575390
20ZAK1.60354879
21CDC71.44962130
22SGK21.42551762
23PIM11.39888322
24MAP2K31.26699336
25MARK21.23417626
26BMPR1B1.15194899
27RPS6KB21.14838034
28MKNK21.12254672
29WNK11.09856990
30PKN21.09120770
31RIPK11.08609459
32LATS11.07604287
33NME11.06393358
34TLK11.02744051
35CHEK10.97289581
36SGK30.94203399
37PIK3CG0.93480478
38NEK90.91293453
39CHEK20.91222418
40SGK4940.88986429
41SGK2230.88986429
42ATR0.88016681
43MAPKAPK30.84941864
44PAK20.84892665
45NLK0.83747437
46MAP3K20.78879505
47MST1R0.78412679
48MAP3K100.78293655
49BRSK20.78062276
50PRKAA20.75767972
51MAP3K30.75277810
52PRKAA10.74346022
53MAP3K130.74203200
54MAP3K60.72782848
55CAMK40.70991163
56PRKD20.69765640
57CDC42BPA0.68010138
58RPS6KA50.67160744
59SIK10.66784883
60CHUK0.64302484
61PDGFRB0.63926249
62NEK60.62871991
63CDK60.61864705
64SMG10.60698012
65AURKB0.60180970
66BTK0.58350384
67HIPK20.57685109
68CDK40.57491574
69MAP3K140.52046283
70RPS6KA60.51346598
71TAOK10.51114209
72TEC0.50414815
73SGK10.49596702
74TTN0.49068432
75MAPK120.47188101
76RPS6KL10.45499489
77RPS6KC10.45499489
78EPHA20.45397170
79MAP3K80.44126870
80AKT10.43032525
81MAPK10.40953183
82SIK20.39796615
83PDK20.39202789
84CDK80.38006376
85RPS6KA10.37026706
86ATM0.36914109
87MAPK70.36502521
88CDK20.36246795
89GSK3B0.35918749
90MAPK140.35665956
91TXK0.34916124
92STK40.33464887
93ITK0.33025035
94NEK20.32849458
95AURKA0.32658527
96CDK10.31334409
97RPS6KB10.31326280
98MAPK80.31013701
99FGFR30.30146412
100STK110.29350015

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053223.02781172
2Lysine degradation_Homo sapiens_hsa003102.33605625
3Alcoholism_Homo sapiens_hsa050342.07414008
4Chronic myeloid leukemia_Homo sapiens_hsa052201.95965081
5Acute myeloid leukemia_Homo sapiens_hsa052211.78582140
6Fanconi anemia pathway_Homo sapiens_hsa034601.77722603
7MicroRNAs in cancer_Homo sapiens_hsa052061.76873498
8Homologous recombination_Homo sapiens_hsa034401.75201993
9Small cell lung cancer_Homo sapiens_hsa052221.72751486
10Cell cycle_Homo sapiens_hsa041101.63771502
11Viral carcinogenesis_Homo sapiens_hsa052031.63191894
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.62888938
13Thyroid cancer_Homo sapiens_hsa052161.48116123
14Prostate cancer_Homo sapiens_hsa052151.47096265
15Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.45978953
16Transcriptional misregulation in cancer_Homo sapiens_hsa052021.45280220
17Dorso-ventral axis formation_Homo sapiens_hsa043201.43778842
18DNA replication_Homo sapiens_hsa030301.43189821
19Non-small cell lung cancer_Homo sapiens_hsa052231.39003082
20TGF-beta signaling pathway_Homo sapiens_hsa043501.38323416
21Phosphatidylinositol signaling system_Homo sapiens_hsa040701.36863451
22Pancreatic cancer_Homo sapiens_hsa052121.35296997
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.35289749
24Vitamin B6 metabolism_Homo sapiens_hsa007501.34226782
25FoxO signaling pathway_Homo sapiens_hsa040681.33141685
26Longevity regulating pathway - mammal_Homo sapiens_hsa042111.31972556
27Bladder cancer_Homo sapiens_hsa052191.26234422
28Colorectal cancer_Homo sapiens_hsa052101.23931962
29Notch signaling pathway_Homo sapiens_hsa043301.23387414
30ErbB signaling pathway_Homo sapiens_hsa040121.20456014
31TNF signaling pathway_Homo sapiens_hsa046681.19734366
32Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19732757
33mTOR signaling pathway_Homo sapiens_hsa041501.19599781
34Hepatitis B_Homo sapiens_hsa051611.16726117
35mRNA surveillance pathway_Homo sapiens_hsa030151.16031873
36Insulin resistance_Homo sapiens_hsa049311.14666453
37ABC transporters_Homo sapiens_hsa020101.14611596
38Endometrial cancer_Homo sapiens_hsa052131.14577739
39Inositol phosphate metabolism_Homo sapiens_hsa005621.13226471
40Adherens junction_Homo sapiens_hsa045201.10889141
41B cell receptor signaling pathway_Homo sapiens_hsa046621.10855599
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09867881
43Type II diabetes mellitus_Homo sapiens_hsa049301.08943210
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02702832
45HTLV-I infection_Homo sapiens_hsa051661.00854910
46T cell receptor signaling pathway_Homo sapiens_hsa046601.00514237
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98882402
48Non-homologous end-joining_Homo sapiens_hsa034500.95326257
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.93705005
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91455991
51Glioma_Homo sapiens_hsa052140.90080574
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89674849
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88920838
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.88003020
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86642835
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86406937
57p53 signaling pathway_Homo sapiens_hsa041150.81682666
58AMPK signaling pathway_Homo sapiens_hsa041520.79381420
59Prolactin signaling pathway_Homo sapiens_hsa049170.77437405
60Hepatitis C_Homo sapiens_hsa051600.77035498
61Measles_Homo sapiens_hsa051620.73480302
62Choline metabolism in cancer_Homo sapiens_hsa052310.72750617
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71800388
64Influenza A_Homo sapiens_hsa051640.70706464
65Apoptosis_Homo sapiens_hsa042100.70446165
66MAPK signaling pathway_Homo sapiens_hsa040100.70187011
67Ovarian steroidogenesis_Homo sapiens_hsa049130.68654559
68Toxoplasmosis_Homo sapiens_hsa051450.68612779
69Circadian rhythm_Homo sapiens_hsa047100.67404263
70Melanoma_Homo sapiens_hsa052180.67111586
71Renal cell carcinoma_Homo sapiens_hsa052110.65793167
72One carbon pool by folate_Homo sapiens_hsa006700.65219952
73Osteoclast differentiation_Homo sapiens_hsa043800.65209852
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64063456
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.62568094
76Wnt signaling pathway_Homo sapiens_hsa043100.62505138
77Epstein-Barr virus infection_Homo sapiens_hsa051690.62012345
78Estrogen signaling pathway_Homo sapiens_hsa049150.61173551
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60867691
80Olfactory transduction_Homo sapiens_hsa047400.60804397
81Herpes simplex infection_Homo sapiens_hsa051680.59554700
82Pathways in cancer_Homo sapiens_hsa052000.58198026
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57853616
84Fatty acid biosynthesis_Homo sapiens_hsa000610.57224541
85Proteoglycans in cancer_Homo sapiens_hsa052050.55962062
86Nucleotide excision repair_Homo sapiens_hsa034200.55841601
87Platelet activation_Homo sapiens_hsa046110.55547472
88Hippo signaling pathway_Homo sapiens_hsa043900.53876522
89Hedgehog signaling pathway_Homo sapiens_hsa043400.52249380
90Glucagon signaling pathway_Homo sapiens_hsa049220.51862358
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.51751614
92Mismatch repair_Homo sapiens_hsa034300.51617268
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.51115646
94VEGF signaling pathway_Homo sapiens_hsa043700.50352821
95Insulin signaling pathway_Homo sapiens_hsa049100.49554897
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49289621
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48885500
98RNA polymerase_Homo sapiens_hsa030200.44748006
99Vitamin digestion and absorption_Homo sapiens_hsa049770.41699667
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.41564278

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