TYROBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.76500318
2positive regulation by symbiont of host defense response (GO:0052509)6.22281537
3modulation by symbiont of host defense response (GO:0052031)6.22281537
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.22281537
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.22281537
6positive regulation by organism of defense response of other organism involved in symbiotic interact6.22281537
7modulation by symbiont of host immune response (GO:0052553)6.22281537
8* neutrophil activation involved in immune response (GO:0002283)5.70525293
9respiratory burst (GO:0045730)5.52164475
10response to peptidoglycan (GO:0032494)5.37549755
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.08047305
12negative regulation of cell killing (GO:0031342)5.08047305
13positive regulation of gamma-delta T cell activation (GO:0046645)4.83764907
14immunoglobulin mediated immune response (GO:0016064)4.82573897
15regulation of interferon-beta biosynthetic process (GO:0045357)4.59787503
16positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.49582267
17microglial cell activation (GO:0001774)4.48543362
18production of molecular mediator involved in inflammatory response (GO:0002532)4.44321227
19hydrogen peroxide biosynthetic process (GO:0050665)4.39657989
20positive regulation of interferon-alpha production (GO:0032727)4.36205389
21detection of other organism (GO:0098543)4.34852194
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.25219856
23superoxide anion generation (GO:0042554)4.24971661
24antigen processing and presentation of endogenous antigen (GO:0019883)4.23193495
25* granulocyte activation (GO:0036230)4.21504178
26* macrophage activation involved in immune response (GO:0002281)4.20299440
27positive regulation of mast cell activation involved in immune response (GO:0033008)4.19627152
28positive regulation of mast cell degranulation (GO:0043306)4.19627152
29reactive oxygen species biosynthetic process (GO:1903409)4.19292662
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.17702966
31response to host immune response (GO:0052572)4.17702966
32positive regulation of mast cell activation (GO:0033005)4.16948491
33detection of bacterium (GO:0016045)4.16656950
34lipopolysaccharide-mediated signaling pathway (GO:0031663)4.14003232
35eosinophil chemotaxis (GO:0048245)4.11529381
36regulation of interferon-alpha production (GO:0032647)4.11517148
37* neutrophil activation (GO:0042119)4.01595175
38regulation of mast cell degranulation (GO:0043304)4.00399222
39* myeloid cell activation involved in immune response (GO:0002275)3.95249670
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.95245249
41regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.91319386
42detection of external biotic stimulus (GO:0098581)3.87216674
43regulation of B cell receptor signaling pathway (GO:0050855)3.85496386
44eosinophil migration (GO:0072677)3.80298776
45positive regulation of antigen processing and presentation (GO:0002579)3.77201138
46regulation of mast cell activation (GO:0033003)3.76793961
47cellular extravasation (GO:0045123)3.76214048
48positive regulation of monocyte chemotaxis (GO:0090026)3.76140232
49regulation of mast cell activation involved in immune response (GO:0033006)3.73630328
50response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.69473169
51response to host (GO:0075136)3.69473169
52response to host defenses (GO:0052200)3.69473169
53leukocyte aggregation (GO:0070486)3.61707747
54positive regulation of cellular amide metabolic process (GO:0034250)3.59890057
55regulation of mononuclear cell migration (GO:0071675)3.54123720
56detection of molecule of bacterial origin (GO:0032490)3.52768526
57leukocyte mediated cytotoxicity (GO:0001909)3.48954013
58B cell mediated immunity (GO:0019724)3.48799476
59response to muramyl dipeptide (GO:0032495)3.47289813
60neutrophil mediated immunity (GO:0002446)3.44301256
61positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.43996093
62detection of biotic stimulus (GO:0009595)3.41815676
63regulation of gamma-delta T cell activation (GO:0046643)3.41196487
64cellular response to type I interferon (GO:0071357)3.39923319
65type I interferon signaling pathway (GO:0060337)3.39923319
66positive regulation of leukocyte degranulation (GO:0043302)3.39683756
67regulation of leukocyte degranulation (GO:0043300)3.38748429
68regulation of myeloid leukocyte mediated immunity (GO:0002886)3.37021227
69* macrophage activation (GO:0042116)3.36963045
70positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.36000344
71monocyte chemotaxis (GO:0002548)3.35658024
72response to type I interferon (GO:0034340)3.35240777
73regulation of T cell tolerance induction (GO:0002664)3.33907836
74negative regulation of cytokine production involved in immune response (GO:0002719)3.33002036
75positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.32983798
76regulation of antigen processing and presentation (GO:0002577)3.28093834
77defense response to protozoan (GO:0042832)3.28012042
78positive regulation of chemokine biosynthetic process (GO:0045080)3.27083268
79pinocytosis (GO:0006907)3.26590931
80cellular response to zinc ion (GO:0071294)3.25377956
81myeloid dendritic cell activation (GO:0001773)3.24181775
82myeloid dendritic cell differentiation (GO:0043011)3.24121045
83germinal center formation (GO:0002467)3.21245776
84neutrophil chemotaxis (GO:0030593)3.21161405
85mast cell activation (GO:0045576)3.20188974
86phagosome maturation (GO:0090382)3.19653882
87negative regulation of mast cell activation (GO:0033004)3.19086851
88regulation of interleukin-8 biosynthetic process (GO:0045414)3.18493514
89positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.17606164
90negative regulation of myeloid cell apoptotic process (GO:0033033)3.17270839
91positive regulation of interferon-beta production (GO:0032728)3.17237258
92* myeloid leukocyte activation (GO:0002274)3.16941700
93lymphocyte chemotaxis (GO:0048247)3.16062077
94positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.15653002
95negative regulation of interleukin-17 production (GO:0032700)3.15540236
96phagocytosis, engulfment (GO:0006911)3.15237481
97regulation of tolerance induction (GO:0002643)3.14345109
98negative regulation of erythrocyte differentiation (GO:0045647)3.13988762
99regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.13912417
100positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.13589422
101negative regulation of lymphocyte mediated immunity (GO:0002707)3.13530511
102neutrophil migration (GO:1990266)3.12245956
103lipoxygenase pathway (GO:0019372)3.11830919
104regulation of monocyte chemotaxis (GO:0090025)3.11787973
105amino sugar catabolic process (GO:0046348)3.11389379
106positive regulation of lymphocyte migration (GO:2000403)3.09353308
107regulation of dendritic cell antigen processing and presentation (GO:0002604)3.05889091
108regulation of T-helper 2 cell differentiation (GO:0045628)3.04520519
109positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.03706932
110NIK/NF-kappaB signaling (GO:0038061)3.03564949
111negative regulation of leukocyte mediated immunity (GO:0002704)3.02219911
112granulocyte chemotaxis (GO:0071621)3.01130875
113interferon-gamma-mediated signaling pathway (GO:0060333)3.00577163
114positive regulation of B cell differentiation (GO:0045579)2.99173376
115natural killer cell mediated immunity (GO:0002228)2.96933696
116natural killer cell mediated cytotoxicity (GO:0042267)2.96933696
117response to protozoan (GO:0001562)2.96826104
118leukocyte degranulation (GO:0043299)2.96591849
119cellular response to thyroid hormone stimulus (GO:0097067)2.95950664
120positive regulation of tumor necrosis factor production (GO:0032760)2.94321363
121regulation of hypersensitivity (GO:0002883)2.92149639
122negative regulation of T cell mediated immunity (GO:0002710)2.91487726
123T-helper 1 type immune response (GO:0042088)2.91437402
124negative regulation of interleukin-12 production (GO:0032695)2.91414827
125glycosphingolipid catabolic process (GO:0046479)2.91126650
126dendritic cell differentiation (GO:0097028)2.90711327
127granulocyte migration (GO:0097530)2.90660077
128cellular response to interferon-beta (GO:0035458)2.90513451
129Arp2/3 complex-mediated actin nucleation (GO:0034314)2.89849366
130positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.89069675
131regulation of regulated secretory pathway (GO:1903305)2.87404348
132regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.87187402
133negative regulation of interleukin-6 production (GO:0032715)2.76139205
134leukocyte migration involved in inflammatory response (GO:0002523)2.76138772
135positive regulation of type 2 immune response (GO:0002830)2.75735248
136regulation of interleukin-12 production (GO:0032655)2.72979760
137cellular response to interferon-gamma (GO:0071346)2.72455929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse7.43556596
2BP1_19119308_ChIP-ChIP_Hs578T_Human7.37434594
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.31203376
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.87899254
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.55362133
6NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse4.02546304
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.84198631
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.74782853
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.73751928
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.40154810
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.13115471
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.96960851
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.95962384
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.86168284
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.77796032
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.71383480
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.57073392
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.56120749
19* SPI1_23547873_ChIP-Seq_NB4_Human2.56068607
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.49895512
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.48594323
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.19916356
23PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.07237609
24SCL_19346495_ChIP-Seq_HPC-7_Human2.05536364
25VDR_24763502_ChIP-Seq_THP-1_Human1.98391987
26PU_27001747_Chip-Seq_BMDM_Mouse1.93291171
27* RUNX1_22412390_ChIP-Seq_EML_Mouse1.91213935
28SPI1_23127762_ChIP-Seq_K562_Human1.85299025
29CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.84534632
30PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.80911880
31CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.80142793
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78046124
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75165602
34VDR_24787735_ChIP-Seq_THP-1_Human1.73739902
35MYB_26560356_Chip-Seq_TH2_Human1.73500269
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.71122660
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69897861
38* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69822566
39LXR_22292898_ChIP-Seq_THP-1_Human1.66751112
40RUNX_20019798_ChIP-Seq_JUKART_Human1.65901256
41VDR_21846776_ChIP-Seq_THP-1_Human1.63864652
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62973886
43MYC_22102868_ChIP-Seq_BL_Human1.60937028
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57005008
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55565805
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55547978
47CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.54946613
48CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.53579045
49KDM2B_26808549_Chip-Seq_DND41_Human1.51976938
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49852998
51* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49637058
52MAF_26560356_Chip-Seq_TH1_Human1.49155453
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46637690
54PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42213856
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39362342
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36315674
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34487927
58MYB_26560356_Chip-Seq_TH1_Human1.32812250
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31629830
60SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31214554
61BCL6_27268052_Chip-Seq_Bcells_Human1.19461756
62GATA3_26560356_Chip-Seq_TH2_Human1.19279804
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18273818
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17439738
65GATA3_27048872_Chip-Seq_THYMUS_Human1.12799443
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11444960
67* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11440710
68BCOR_27268052_Chip-Seq_Bcells_Human1.11122444
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08512903
70VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08067850
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07833973
72UTX_26944678_Chip-Seq_JUKART_Human1.06438395
73STAT1_20625510_ChIP-Seq_HELA_Human1.01238000
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.00596267
75IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97531373
76* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97101937
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96462789
78SMAD_19615063_ChIP-ChIP_OVARY_Human0.94115946
79GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93715941
80EGR1_19032775_ChIP-ChIP_M12_Human0.91865894
81* ELF1_20517297_ChIP-Seq_JURKAT_Human0.90390731
82NCOR1_26117541_ChIP-Seq_K562_Human0.86685678
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86539753
84KDM2B_26808549_Chip-Seq_JURKAT_Human0.86251887
85SPI1_20517297_ChIP-Seq_HL60_Human0.86162719
86SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86032083
87TFEB_21752829_ChIP-Seq_HELA_Human0.85951929
88TCF7_22412390_ChIP-Seq_EML_Mouse0.85848399
89CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83689998
90RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83362885
91GATA1_19941827_ChIP-Seq_MEL_Mouse0.82047111
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.79052326
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78403496
94E2F7_22180533_ChIP-Seq_HELA_Human0.78062584
95HOXB4_20404135_ChIP-ChIP_EML_Mouse0.77988812
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77556696
97SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.74819592
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.74605595
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.73810504
100MAF_26560356_Chip-Seq_TH2_Human0.72184850
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.71015114
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69083398
103GATA1_22025678_ChIP-Seq_K562_Human0.67938895
104ELK3_25401928_ChIP-Seq_HUVEC_Human0.67077091
105GATA2_19941826_ChIP-Seq_K562_Human0.65894467
106* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.65666755
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.65016777
108ERG_20887958_ChIP-Seq_HPC-7_Mouse0.64081726
109CDX2_19796622_ChIP-Seq_MESCs_Mouse0.62348586
110NRF2_20460467_ChIP-Seq_MEFs_Mouse0.61341985
111NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.61341985
112GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61264150
113CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.60687840
114GATA1_19941826_ChIP-Seq_K562_Human0.59569484
115SMRT_27268052_Chip-Seq_Bcells_Human0.59490143
116SOX2_20726797_ChIP-Seq_SW620_Human0.58574279
117CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.56283956
118ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.56178435
119ETS1_22383799_ChIP-Seq_G1ME_Mouse0.55205035
120CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.54935334

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.94981665
2* MP0003436_decreased_susceptibility_to4.03963744
3* MP0002148_abnormal_hypersensitivity_rea3.79435120
4* MP0002419_abnormal_innate_immunity3.57461245
5MP0009785_altered_susceptibility_to3.57092665
6MP0003303_peritoneal_inflammation3.48017029
7MP0005058_abnormal_lysosome_morphology3.44503960
8MP0006082_CNS_inflammation3.38049556
9* MP0005000_abnormal_immune_tolerance3.28507844
10* MP0005025_abnormal_response_to3.04602649
11MP0003724_increased_susceptibility_to2.79600516
12* MP0002452_abnormal_antigen_presenting2.74708531
13MP0005387_immune_system_phenotype2.63787673
14MP0001790_abnormal_immune_system2.63787673
15MP0005671_abnormal_response_to2.57869209
16* MP0002723_abnormal_immune_serum2.54113367
17MP0001800_abnormal_humoral_immune2.49566851
18MP0005464_abnormal_platelet_physiology2.42600321
19MP0003172_abnormal_lysosome_physiology2.38033009
20* MP0001819_abnormal_immune_cell2.34084578
21* MP0002420_abnormal_adaptive_immunity2.32195658
22MP0000685_abnormal_immune_system2.31205408
23MP0003191_abnormal_cellular_cholesterol2.16977728
24MP0004510_myositis2.13432088
25* MP0001533_abnormal_skeleton_physiology2.13015534
26MP0001853_heart_inflammation2.12007777
27MP0002405_respiratory_system_inflammati2.09448674
28MP0000343_altered_response_to2.08739571
29MP0001845_abnormal_inflammatory_respons1.99281224
30MP0003075_altered_response_to1.94970034
31MP0009840_abnormal_foam_cell1.88541827
32MP0009764_decreased_sensitivity_to1.86126225
33MP0008469_abnormal_protein_level1.73266041
34MP0003448_altered_tumor_morphology1.68668520
35MP0005310_abnormal_salivary_gland1.67596653
36* MP0000716_abnormal_immune_system1.63366099
37MP0009333_abnormal_splenocyte_physiolog1.60196107
38MP0010155_abnormal_intestine_physiology1.57844825
39MP0003806_abnormal_nucleotide_metabolis1.56201851
40MP0003690_abnormal_glial_cell1.55850378
41MP0002006_tumorigenesis1.55072459
42MP0004947_skin_inflammation1.50642490
43MP0000858_altered_metastatic_potential1.48896756
44MP0005166_decreased_susceptibility_to1.47617569
45* MP0002398_abnormal_bone_marrow1.46699967
46MP0003183_abnormal_peptide_metabolism1.43906503
47* MP0002998_abnormal_bone_remodeling1.39095745
48MP0009278_abnormal_bone_marrow1.38688710
49MP0006054_spinal_hemorrhage1.35672320
50MP0000689_abnormal_spleen_morphology1.33427091
51MP0004782_abnormal_surfactant_physiolog1.32566141
52* MP0002429_abnormal_blood_cell1.31818643
53MP0008004_abnormal_stomach_pH1.31316943
54MP0000604_amyloidosis1.29951815
55MP0005174_abnormal_tail_pigmentation1.29887390
56MP0005167_abnormal_blood-brain_barrier1.28991548
57MP0002139_abnormal_hepatobiliary_system1.27768980
58MP0002277_abnormal_respiratory_mucosa1.24758167
59MP0000569_abnormal_digit_pigmentation1.22573151
60MP0002166_altered_tumor_susceptibility1.20705790
61MP0002722_abnormal_immune_system1.19239424
62MP0001545_abnormal_hematopoietic_system1.18511379
63MP0005397_hematopoietic_system_phenotyp1.18511379
64MP0005164_abnormal_response_to1.14988417
65MP0003828_pulmonary_edema1.13662641
66MP0001851_eye_inflammation1.11336178
67MP0003186_abnormal_redox_activity1.10644018
68MP0003300_gastrointestinal_ulcer1.02711726
69MP0000465_gastrointestinal_hemorrhage1.00056430
70MP0009763_increased_sensitivity_to0.98068709
71MP0002933_joint_inflammation0.95956528
72* MP0005390_skeleton_phenotype0.95796787
73MP0004883_abnormal_blood_vessel0.95736518
74MP0002254_reproductive_system_inflammat0.95362783
75MP0010307_abnormal_tumor_latency0.94084412
76MP0000249_abnormal_blood_vessel0.91113352
77MP0003329_amyloid_beta_deposits0.89532297
78MP0002132_abnormal_respiratory_system0.84357597
79MP0008260_abnormal_autophagy0.83613853
80MP0000490_abnormal_crypts_of0.81910285
81MP0000015_abnormal_ear_pigmentation0.78853373
82MP0005076_abnormal_cell_differentiation0.74873926
83MP0002090_abnormal_vision0.74733133
84MP0002332_abnormal_exercise_endurance0.74045292
85MP0000371_diluted_coat_color0.72725098
86MP0003656_abnormal_erythrocyte_physiolo0.72408034
87* MP0003795_abnormal_bone_structure0.70710271
88MP0001542_abnormal_bone_strength0.68865485
89MP0001663_abnormal_digestive_system0.68316846
90MP0002138_abnormal_hepatobiliary_system0.67886415
91MP0002136_abnormal_kidney_physiology0.66470426
92MP0009765_abnormal_xenobiotic_induced0.65744330
93MP0008874_decreased_physiological_sensi0.65160384
94MP0001873_stomach_inflammation0.64644045
95MP0005257_abnormal_intraocular_pressure0.64351866
96MP0002396_abnormal_hematopoietic_system0.63161112
97MP0003866_abnormal_defecation0.60773864
98* MP0000920_abnormal_myelination0.60341108
99MP0005319_abnormal_enzyme/_coenzyme0.60292163
100MP0004808_abnormal_hematopoietic_stem0.58148283
101MP0005365_abnormal_bile_salt0.58077827
102MP0003763_abnormal_thymus_physiology0.56259829
103MP0003566_abnormal_cell_adhesion0.56218722
104MP0000767_abnormal_smooth_muscle0.56158194
105MP0008438_abnormal_cutaneous_collagen0.53302968
106MP0003091_abnormal_cell_migration0.51744180
107MP0005165_increased_susceptibility_to0.51046298
108MP0000703_abnormal_thymus_morphology0.50556313
109MP0005381_digestive/alimentary_phenotyp0.50427442
110MP0003879_abnormal_hair_cell0.49973168
111MP0003195_calcinosis0.49300297
112MP0004381_abnormal_hair_follicle0.49119126
113MP0004858_abnormal_nervous_system0.48899882
114* MP0008873_increased_physiological_sensi0.48290030
115MP0000609_abnormal_liver_physiology0.47676579
116MP0005584_abnormal_enzyme/coenzyme_acti0.47482830
117MP0003453_abnormal_keratinocyte_physiol0.47227374
118MP0005451_abnormal_body_composition0.47109126
119MP0002693_abnormal_pancreas_physiology0.43991820

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)8.45656464
2Eczematoid dermatitis (HP:0000976)7.93948367
3Recurrent bacterial skin infections (HP:0005406)7.72297983
4Recurrent gram-negative bacterial infections (HP:0005420)6.99472264
5Abnormality of macrophages (HP:0004311)5.67758131
6Systemic lupus erythematosus (HP:0002725)5.57604940
7Mediastinal lymphadenopathy (HP:0100721)5.11406322
8Vacuolated lymphocytes (HP:0001922)5.10846617
9Increased cerebral lipofuscin (HP:0011813)4.83994241
10Increased neuronal autofluorescent lipopigment (HP:0002074)4.74358859
11Recurrent skin infections (HP:0001581)4.67632669
12Obstructive lung disease (HP:0006536)4.61472202
13Chronic obstructive pulmonary disease (HP:0006510)4.61472202
14Gingivitis (HP:0000230)4.53518152
15Myositis (HP:0100614)4.04934843
16Abnormality of glycolipid metabolism (HP:0010969)4.04442506
17Abnormality of liposaccharide metabolism (HP:0010968)4.04442506
18Abnormality of glycosphingolipid metabolism (HP:0004343)4.04442506
19Glomerulonephritis (HP:0000099)4.04272745
20Elevated erythrocyte sedimentation rate (HP:0003565)3.99567824
21Recurrent fungal infections (HP:0002841)3.97318550
22Orchitis (HP:0100796)3.58389887
23Dysostosis multiplex (HP:0000943)3.57844231
24Stomatitis (HP:0010280)3.56491419
25Autoimmune thrombocytopenia (HP:0001973)3.55771004
26Optic neuritis (HP:0100653)3.33417332
27Retrobulbar optic neuritis (HP:0100654)3.33417332
28Cellulitis (HP:0100658)3.26718620
29Mutism (HP:0002300)3.25486075
30Amyloidosis (HP:0011034)3.08360515
31Urticaria (HP:0001025)3.08254432
32Pustule (HP:0200039)3.04834098
33Meningitis (HP:0001287)3.01485722
34Recurrent cutaneous fungal infections (HP:0011370)3.01230561
35Chronic mucocutaneous candidiasis (HP:0002728)3.01230561
36Vasculitis (HP:0002633)3.00394089
37Periodontitis (HP:0000704)2.98325539
38Encephalitis (HP:0002383)2.97172953
39Recurrent viral infections (HP:0004429)2.95319698
40Recurrent pneumonia (HP:0006532)2.93853809
41Prostate neoplasm (HP:0100787)2.92435673
42Gastrointestinal infarctions (HP:0005244)2.91177930
43Interstitial pulmonary disease (HP:0006530)2.90715778
44Neurofibrillary tangles (HP:0002185)2.81104829
45Mucopolysacchariduria (HP:0008155)2.77767040
46Urinary glycosaminoglycan excretion (HP:0003541)2.77767040
47Increased serum ferritin (HP:0003281)2.74970159
48Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.74949641
49Spontaneous hematomas (HP:0007420)2.68570424
50Petechiae (HP:0000967)2.67428892
51Thick nail (HP:0001805)2.67024883
52Osteomyelitis (HP:0002754)2.66067007
53Increased IgE level (HP:0003212)2.64950866
54Hepatosplenomegaly (HP:0001433)2.63271826
55Joint hemorrhage (HP:0005261)2.58747672
56Nephritis (HP:0000123)2.58161721
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.56269487
58Abnormality of polysaccharide metabolism (HP:0011012)2.56269487
59Abnormality of glycosaminoglycan metabolism (HP:0004371)2.56269487
60Pulmonary infiltrates (HP:0002113)2.56153797
61Abnormality of complement system (HP:0005339)2.54868073
62T lymphocytopenia (HP:0005403)2.52477412
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.46139966
64Recurrent lower respiratory tract infections (HP:0002783)2.44885708
65Poor head control (HP:0002421)2.41864213
66Neuronal loss in central nervous system (HP:0002529)2.39737396
67Pulmonary embolism (HP:0002204)2.37270599
68Myocardial infarction (HP:0001658)2.36006825
69* Disinhibition (HP:0000734)2.35669346
70Abnormality of iron homeostasis (HP:0011031)2.35413868
71* Basal ganglia calcification (HP:0002135)2.35089687
72Abnormality of T cell number (HP:0011839)2.35076973
73Chest pain (HP:0100749)2.33046036
74Leukocytosis (HP:0001974)2.29615879
75Hemoptysis (HP:0002105)2.27922325
76Complement deficiency (HP:0004431)2.27616491
77Anorexia (HP:0002039)2.26257908
78Prolonged bleeding time (HP:0003010)2.25971166
79Nuclear cataract (HP:0100018)2.25246828
80Polyneuropathy (HP:0001271)2.24817770
81Gangrene (HP:0100758)2.24452378
82Episodic fever (HP:0001954)2.23629513
83Progressive neurologic deterioration (HP:0002344)2.23429747
84Abnormality of the prostate (HP:0008775)2.21779909
85Loss of speech (HP:0002371)2.20995413
86Hematochezia (HP:0002573)2.17963452
87Gingival bleeding (HP:0000225)2.11989683
88Hypergammaglobulinemia (HP:0010702)2.11399145
89Arterial thrombosis (HP:0004420)2.10609368
90Abnormality of the nasal mucosa (HP:0000433)2.10061577
91Diminished motivation (HP:0000745)2.09738677
92Osteolytic defects of the hand bones (HP:0009699)2.08670170
93Osteolytic defects of the phalanges of the hand (HP:0009771)2.08670170
94Sepsis (HP:0100806)2.08117549
95Increased IgM level (HP:0003496)2.07179304
96Purpura (HP:0000979)2.06642001
97Progressive visual loss (HP:0000529)2.06424444
98Apathy (HP:0000741)2.05714278
99Keratoconjunctivitis sicca (HP:0001097)2.02691745
100Malnutrition (HP:0004395)1.98977853
101Abnormality of the vasculature of the conjunctiva (HP:0008054)1.98069747
102Epistaxis (HP:0000421)1.96929837
103* Axonal loss (HP:0003447)1.95956108
104Cerebral inclusion bodies (HP:0100314)1.95820191
105IgM deficiency (HP:0002850)1.95797729
106* Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.95322867
107Chronic otitis media (HP:0000389)1.95135776
108Cheilitis (HP:0100825)1.93973938
109Inflammation of the large intestine (HP:0002037)1.93219017
110J-shaped sella turcica (HP:0002680)1.92735934
111Colitis (HP:0002583)1.92605817
112Tetraparesis (HP:0002273)1.92080611
113Glomerulopathy (HP:0100820)1.91872450
114Vertigo (HP:0002321)1.91397295
115Eosinophilia (HP:0001880)1.88879448
116Skin ulcer (HP:0200042)1.88593629
117Abnormality of transition element cation homeostasis (HP:0011030)1.87845535
118Acne (HP:0001061)1.87594856
119Restrictive lung disease (HP:0002091)1.87099209
120Hypochromic anemia (HP:0001931)1.86407977
121Thoracic kyphosis (HP:0002942)1.84272486
122Keratoconjunctivitis (HP:0001096)1.83177545
123Albinism (HP:0001022)1.81551135
124Abnormality of the pleura (HP:0002103)1.79532162
125Abnormality of the lumbar spine (HP:0100712)1.78459466
126Gastrointestinal inflammation (HP:0004386)1.76489475
127Premature loss of primary teeth (HP:0006323)1.75985457
128Thrombocytosis (HP:0001894)1.74764536
129* Bone pain (HP:0002653)1.73647723
130Nausea (HP:0002018)1.72301665

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.94474913
2RIPK44.73530436
3IRAK43.91929649
4MAP3K143.64294479
5TBK12.97905177
6IRAK32.93916148
7TYK22.91459428
8PBK2.71146392
9MAP4K12.57225889
10KIT2.30978908
11IKBKB2.13744951
12TAOK12.10867629
13TGFBR22.06314344
14TXK2.03575283
15IKBKE1.94084886
16PIM21.92394317
17PRPF4B1.90947149
18ERN11.87507174
19TNK21.83930871
20TAOK21.76647097
21CSK1.68332906
22CSF1R1.66087499
23JAK11.65385234
24BTK1.65124654
25JAK31.61348601
26TEC1.60740793
27NME21.54163178
28HCK1.50316788
29LYN1.50188693
30ZAP701.48039448
31CLK11.41057970
32FES1.36924381
33ABL21.33728199
34TAOK31.32029523
35GRK71.31918360
36NEK91.28502250
37PIM11.21236778
38SIK31.19660195
39TESK21.18654274
40MATK1.18423737
41* SYK1.17820741
42MAP2K31.15393537
43STK101.09492494
44MST41.09051974
45EPHB11.05044160
46JAK21.04539878
47CDC42BPA1.03712172
48CHUK1.03403523
49YES11.02432706
50FGR1.01303378
51RPS6KA40.99858990
52BMPR20.98360179
53TRPM70.98170653
54MAP3K100.97808336
55* LCK0.96544549
56ITK0.95520997
57DDR20.91834458
58ARAF0.90836263
59MAP3K130.90372355
60STK40.88753205
61MST1R0.88721769
62BMX0.83611789
63PRKCD0.80883159
64ADRBK20.77739707
65EIF2AK20.77690437
66MARK20.75254989
67MARK30.71974454
68BMPR1B0.70161498
69MAP2K60.69256156
70KSR20.66116200
71ABL10.65593195
72LRRK20.65572559
73RIPK10.62907814
74MAP3K120.61412417
75ERBB30.61001580
76EGFR0.59625576
77MAPK120.59212126
78IRAK20.58956674
79SCYL20.58951217
80PRKD20.58634939
81MAP3K110.58408574
82MAP3K30.56707565
83CAMKK20.54913621
84PAK40.53934445
85MAPK70.53495724
86MOS0.51013795
87DAPK20.48949587
88RPS6KA60.48811655
89CAMK1D0.46323569
90IRAK10.45400154
91ACVR1B0.45034590
92TRIB30.44507661
93GRK60.44216865
94MAPKAPK20.44017830
95PIK3CG0.41392387
96SIK10.40965650
97MAP3K50.40594375
98MAP3K60.39993903
99CDK190.39888220
100EIF2AK30.39510853
101PTK60.39181779
102DYRK1B0.39170756
103TESK10.37236383
104RPS6KC10.37001061
105RPS6KL10.37001061
106FYN0.36444752
107PRKCQ0.36071816
108CDK60.35704308
109CAMKK10.34573942
110FGFR30.33856818
111HIPK20.33410350
112PDK10.32316301
113PRKG20.32234753
114EPHA30.30966695
115SIK20.30542443
116IGF1R0.28912541
117PDPK10.28830223
118MAP3K10.28207654
119MAPK40.26526979
120MAP3K80.25648675
121FLT30.25417622
122STK30.24775167
123PKN20.23321685
124KDR0.22302418
125RPS6KA20.21132816
126TTN0.20912147

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.92726752
2Leishmaniasis_Homo sapiens_hsa051403.56901424
3Graft-versus-host disease_Homo sapiens_hsa053322.80971763
4Lysosome_Homo sapiens_hsa041422.77598584
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.70087476
6Pertussis_Homo sapiens_hsa051332.53938938
7* Osteoclast differentiation_Homo sapiens_hsa043802.52013700
8Legionellosis_Homo sapiens_hsa051342.51472425
9Tuberculosis_Homo sapiens_hsa051522.49904929
10Other glycan degradation_Homo sapiens_hsa005112.45066060
11Rheumatoid arthritis_Homo sapiens_hsa053232.36125105
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.29400549
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.24863892
14Phagosome_Homo sapiens_hsa041452.23148212
15Asthma_Homo sapiens_hsa053102.21060955
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.16732886
17NOD-like receptor signaling pathway_Homo sapiens_hsa046212.11911340
18Malaria_Homo sapiens_hsa051442.10641188
19Allograft rejection_Homo sapiens_hsa053302.08631560
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.91305377
21Salmonella infection_Homo sapiens_hsa051321.84548050
22Measles_Homo sapiens_hsa051621.80953409
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73573636
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.73337402
25B cell receptor signaling pathway_Homo sapiens_hsa046621.64314398
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.59834573
27Influenza A_Homo sapiens_hsa051641.49809748
28Chemokine signaling pathway_Homo sapiens_hsa040621.48496027
29Type I diabetes mellitus_Homo sapiens_hsa049401.48210079
30Hematopoietic cell lineage_Homo sapiens_hsa046401.47593004
31Antigen processing and presentation_Homo sapiens_hsa046121.45644998
32Toxoplasmosis_Homo sapiens_hsa051451.45579469
33* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.44024893
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.43488125
35TNF signaling pathway_Homo sapiens_hsa046681.40503424
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37170568
37Apoptosis_Homo sapiens_hsa042101.32565693
38Shigellosis_Homo sapiens_hsa051311.28882334
39Herpes simplex infection_Homo sapiens_hsa051681.23569275
40African trypanosomiasis_Homo sapiens_hsa051431.19227447
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18217255
42Complement and coagulation cascades_Homo sapiens_hsa046101.12276222
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10791330
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.09539330
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09521382
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07512946
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03317294
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.99842668
49Collecting duct acid secretion_Homo sapiens_hsa049660.99617229
50Viral myocarditis_Homo sapiens_hsa054160.98464955
51Autoimmune thyroid disease_Homo sapiens_hsa053200.92650100
52Hepatitis B_Homo sapiens_hsa051610.91051479
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86557762
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84296000
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83140873
56Primary immunodeficiency_Homo sapiens_hsa053400.81944594
57Amoebiasis_Homo sapiens_hsa051460.80438428
58Prion diseases_Homo sapiens_hsa050200.75181789
59Hepatitis C_Homo sapiens_hsa051600.71254755
60Platelet activation_Homo sapiens_hsa046110.70510738
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68727502
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64499497
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61560958
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61168237
65T cell receptor signaling pathway_Homo sapiens_hsa046600.59293941
66Acute myeloid leukemia_Homo sapiens_hsa052210.59086604
67Pancreatic cancer_Homo sapiens_hsa052120.55464088
68Bladder cancer_Homo sapiens_hsa052190.53385830
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.52848940
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52010558
71Sphingolipid metabolism_Homo sapiens_hsa006000.51230707
72Renin-angiotensin system_Homo sapiens_hsa046140.49661988
73Chronic myeloid leukemia_Homo sapiens_hsa052200.48417762
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.48116879
75Caffeine metabolism_Homo sapiens_hsa002320.44451051
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44177396
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42821033
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42577054
79Epstein-Barr virus infection_Homo sapiens_hsa051690.42086045
80Mineral absorption_Homo sapiens_hsa049780.41340830
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.40602019
82Vibrio cholerae infection_Homo sapiens_hsa051100.38826429
83Non-small cell lung cancer_Homo sapiens_hsa052230.38008028
84Notch signaling pathway_Homo sapiens_hsa043300.37695482
85Renal cell carcinoma_Homo sapiens_hsa052110.34982561
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33644393
87Endocytosis_Homo sapiens_hsa041440.33194550
88GnRH signaling pathway_Homo sapiens_hsa049120.32714669
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30413910
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29979719
91HIF-1 signaling pathway_Homo sapiens_hsa040660.28324368
92Arachidonic acid metabolism_Homo sapiens_hsa005900.28126180
93Galactose metabolism_Homo sapiens_hsa000520.26417152
94Viral carcinogenesis_Homo sapiens_hsa052030.24004889
95MAPK signaling pathway_Homo sapiens_hsa040100.24002044
96Prolactin signaling pathway_Homo sapiens_hsa049170.23402984
97Systemic lupus erythematosus_Homo sapiens_hsa053220.21675640
98FoxO signaling pathway_Homo sapiens_hsa040680.21573753
99Insulin resistance_Homo sapiens_hsa049310.21261017
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.21105024
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.20948578
102VEGF signaling pathway_Homo sapiens_hsa043700.20192622
103Dorso-ventral axis formation_Homo sapiens_hsa043200.19497618
104Proteoglycans in cancer_Homo sapiens_hsa052050.14290420
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.14074749
106Pentose phosphate pathway_Homo sapiens_hsa000300.11771869
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11065808
108Steroid biosynthesis_Homo sapiens_hsa001000.10621423
109HTLV-I infection_Homo sapiens_hsa051660.10424652
110Small cell lung cancer_Homo sapiens_hsa052220.10353857
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.07802412
112Type II diabetes mellitus_Homo sapiens_hsa049300.06708314
113Ether lipid metabolism_Homo sapiens_hsa005650.06661534
114Histidine metabolism_Homo sapiens_hsa003400.06415350

Most similar genes based on co-expression Upload to Enrichr

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