TYRP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* pigment biosynthetic process (GO:0046148)7.23679240
2regulation of endothelial cell chemotaxis (GO:2001026)6.02259283
3* pigment metabolic process (GO:0042440)5.57120478
4myotube differentiation (GO:0014902)5.53159745
5mesenchymal-epithelial cell signaling (GO:0060638)5.39048451
6endosome to pigment granule transport (GO:0043485)5.34863176
7endosome to melanosome transport (GO:0035646)5.34863176
8* melanocyte differentiation (GO:0030318)5.33440075
9negative regulation of hydrogen peroxide-induced cell death (GO:1903206)5.25805868
10pigmentation (GO:0043473)5.18808031
11positive regulation of neuroblast proliferation (GO:0002052)5.09000744
12* pigment cell differentiation (GO:0050931)4.84474695
13negative regulation of response to reactive oxygen species (GO:1901032)4.77305247
14calcium-mediated signaling using intracellular calcium source (GO:0035584)4.75070735
15pigment granule transport (GO:0051904)4.74861727
16aromatic amino acid family metabolic process (GO:0009072)4.74610902
17melanosome transport (GO:0032402)4.72555194
18regulation of hydrogen peroxide-induced cell death (GO:1903205)4.71294974
19establishment of pigment granule localization (GO:0051905)4.53014466
20establishment of melanosome localization (GO:0032401)4.49819718
21pigment granule localization (GO:0051875)4.44825384
22regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.42373142
23melanosome localization (GO:0032400)4.41555653
24endothelial cell morphogenesis (GO:0001886)4.18778847
25* melanosome organization (GO:0032438)4.00330051
26* melanin biosynthetic process (GO:0042438)33.6385552
27* melanin metabolic process (GO:0006582)30.2483781
28nerve growth factor signaling pathway (GO:0038180)3.98945234
29regulation of integrin-mediated signaling pathway (GO:2001044)3.88814707
30* phenol-containing compound metabolic process (GO:0018958)3.80888614
31* pigment granule organization (GO:0048753)3.78997469
32somatic stem cell division (GO:0048103)3.76233963
33semaphorin-plexin signaling pathway (GO:0071526)3.73447297
34proline transport (GO:0015824)3.72449443
35vitamin A metabolic process (GO:0006776)3.66914261
36regulation of neuroblast proliferation (GO:1902692)3.57417085
37regulation of superoxide anion generation (GO:0032928)3.50016108
38mitotic G1 DNA damage checkpoint (GO:0031571)3.27403814
39negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.25478046
40antigen processing and presentation via MHC class Ib (GO:0002475)3.25330210
41* neuroepithelial cell differentiation (GO:0060563)3.25142496
42positive regulation of receptor recycling (GO:0001921)3.21538262
43regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.20371078
44regulation of somitogenesis (GO:0014807)3.19899498
45muscle cell migration (GO:0014812)3.13847015
46regulation of protein sumoylation (GO:0033233)3.12346806
47G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.10769695
48ventricular cardiac muscle cell development (GO:0055015)3.10304052
49negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.10016359
50negative regulation of interleukin-1 beta production (GO:0032691)3.10004076
51enteric nervous system development (GO:0048484)3.07596574
52barbed-end actin filament capping (GO:0051016)3.01839921
53* secondary metabolite biosynthetic process (GO:0044550)27.4695234
54regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.95598663
55retinal rod cell development (GO:0046548)2.89023727
56positive regulation of DNA-dependent DNA replication (GO:2000105)2.88742521
57diterpenoid biosynthetic process (GO:0016102)2.87206007
58response to epinephrine (GO:0071871)2.85564380
59mitotic G1/S transition checkpoint (GO:0044819)2.82953591
60fibroblast migration (GO:0010761)2.80828485
61G1 DNA damage checkpoint (GO:0044783)2.78849676
62righting reflex (GO:0060013)2.75271013
63cell migration involved in heart development (GO:0060973)2.72164237
64dosage compensation (GO:0007549)2.71741003
65negative regulation of organelle assembly (GO:1902116)2.70417138
66response to iron ion (GO:0010039)2.69221534
67regulation of response to reactive oxygen species (GO:1901031)2.68757944
68cellular response to reactive nitrogen species (GO:1902170)2.62455166
69bone remodeling (GO:0046849)2.62337892
70response to magnesium ion (GO:0032026)2.59570950
71stress fiber assembly (GO:0043149)2.58294351
72positive regulation of neural precursor cell proliferation (GO:2000179)2.57263952
73mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.56654230
74negative regulation of oxidative stress-induced cell death (GO:1903202)2.54509688
75cellular response to nitric oxide (GO:0071732)2.53394649
76negative regulation of JUN kinase activity (GO:0043508)2.53016497
77behavioral response to ethanol (GO:0048149)2.52675606
78Rap protein signal transduction (GO:0032486)2.51936074
79regulation of superoxide metabolic process (GO:0090322)2.50570725
80hair cell differentiation (GO:0035315)2.49993237
81polyol catabolic process (GO:0046174)2.49484169
82cellular response to thyroid hormone stimulus (GO:0097067)2.46460960
83negative regulation of response to oxidative stress (GO:1902883)2.44424662
84negative regulation of cellular response to oxidative stress (GO:1900408)2.44424662
85negative regulation of interleukin-1 production (GO:0032692)2.42690624
86peripheral nervous system development (GO:0007422)2.42431176
87negative regulation of fatty acid biosynthetic process (GO:0045717)2.42162645
88stem cell division (GO:0017145)2.40685093
89signal peptide processing (GO:0006465)2.40050869
90cellular response to oxygen radical (GO:0071450)2.37484479
91removal of superoxide radicals (GO:0019430)2.37484479
92cellular response to superoxide (GO:0071451)2.37484479
93pinocytosis (GO:0006907)2.37285790
94Rac protein signal transduction (GO:0016601)2.36857409
95regulation of sister chromatid cohesion (GO:0007063)2.36375872
96platelet dense granule organization (GO:0060155)2.35916917
97mitotic G2 DNA damage checkpoint (GO:0007095)2.34116432
98response to nerve growth factor (GO:1990089)2.33129353
99cellular response to nerve growth factor stimulus (GO:1990090)2.33129353
100auditory receptor cell stereocilium organization (GO:0060088)2.31275906
101regulation of DNA endoreduplication (GO:0032875)2.30680991
102negative regulation of cell cycle arrest (GO:0071157)2.30578611
103negative regulation of chemokine production (GO:0032682)2.30107994
104regulation of cellular respiration (GO:0043457)2.28687219
105establishment of nucleus localization (GO:0040023)2.23984164
106response to thyroid hormone (GO:0097066)2.23216531
107autophagic vacuole fusion (GO:0000046)2.22101847
108vesicle localization (GO:0051648)2.20609218
109antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.18859935
110regulation of centriole replication (GO:0046599)2.18367822
111negative regulation of TOR signaling (GO:0032007)2.17362249
112response to nitric oxide (GO:0071731)2.15922376
113alanine transport (GO:0032328)2.15742882
114regulation of clathrin-mediated endocytosis (GO:2000369)2.15468249
115piRNA metabolic process (GO:0034587)2.15207703
1164-hydroxyproline metabolic process (GO:0019471)2.14977240
117regulation of lipoprotein metabolic process (GO:0050746)2.14710313
118intracellular pH reduction (GO:0051452)2.14021752
119terpenoid biosynthetic process (GO:0016114)2.10342091
120positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.09769661
121osteoclast differentiation (GO:0030316)2.09023430
122mitotic sister chromatid segregation (GO:0000070)2.07536839
123* organic hydroxy compound biosynthetic process (GO:1901617)2.02753787
124positive regulation of glucose transport (GO:0010828)2.02709012
125tyrosine metabolic process (GO:0006570)15.4107738
126developmental pigmentation (GO:0048066)13.1548495
127* phenol-containing compound biosynthetic process (GO:0046189)10.4292678
128* secondary metabolic process (GO:0019748)10.1922321
129negative regulation of fatty acid metabolic process (GO:0045922)1.98240736
130myelin assembly (GO:0032288)1.93287061
131regulation of apoptotic cell clearance (GO:2000425)1.92841434
132regulation of early endosome to late endosome transport (GO:2000641)1.90621972
133peptidyl-lysine dimethylation (GO:0018027)1.87012199
134cellular glucuronidation (GO:0052695)1.86888130
135positive chemotaxis (GO:0050918)1.85886799
136positive regulation of osteoblast proliferation (GO:0033690)1.85785901
137* columnar/cuboidal epithelial cell differentiation (GO:0002065)1.84077573
138regulation of short-term neuronal synaptic plasticity (GO:0048172)1.79927221
139regulation of oxidative stress-induced cell death (GO:1903201)1.79544476
140establishment of mitotic spindle orientation (GO:0000132)1.77928466
141centrosome duplication (GO:0051298)1.76126727
142negative regulation of histone methylation (GO:0031061)1.74949740
143negative regulation of membrane potential (GO:0045837)1.73935604
144glycoprotein catabolic process (GO:0006516)1.73640498
145folic acid-containing compound biosynthetic process (GO:0009396)1.71932624
146positive regulation of Rap GTPase activity (GO:0032854)1.71267409
147protein K6-linked ubiquitination (GO:0085020)1.70135664
148uronic acid metabolic process (GO:0006063)1.67571097
149glucuronate metabolic process (GO:0019585)1.67571097
150organelle membrane fusion (GO:0090174)1.65655844
151glycolytic process (GO:0006096)1.65268944
152regulation of cellular response to oxidative stress (GO:1900407)1.63829646
153specification of organ identity (GO:0010092)1.61497009
154inositol phosphate dephosphorylation (GO:0046855)1.60216085
155phosphorylated carbohydrate dephosphorylation (GO:0046838)1.60216085
156angiogenesis involved in wound healing (GO:0060055)1.59566403
157inositol phosphate catabolic process (GO:0071545)1.58529238
158regulation of histone H3-K9 methylation (GO:0051570)1.57869878
159chondroitin sulfate biosynthetic process (GO:0030206)1.56838336
160establishment of mitotic spindle localization (GO:0040001)1.53894666
161centrosome localization (GO:0051642)1.53322444
162spinal cord association neuron differentiation (GO:0021527)1.52526971
163thymus development (GO:0048538)1.51842146
164glycogen biosynthetic process (GO:0005978)1.51422320

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat8.85837147
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.38280908
3GATA1_22025678_ChIP-Seq_K562_Human4.51871361
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.27414444
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.93029761
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.81745880
7E2F7_22180533_ChIP-Seq_HELA_Human3.49468297
8ESR1_20079471_ChIP-ChIP_T-47D_Human3.35826256
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.31286461
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.30647435
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.87259705
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.84701908
13CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.77058446
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.76286128
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.76119299
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.56801393
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.36608388
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25036103
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.23183641
20EGR1_19032775_ChIP-ChIP_M12_Human2.15105421
21PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.02751096
22RBPJ_22232070_ChIP-Seq_NCS_Mouse10.3110953
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89415139
24TFEB_21752829_ChIP-Seq_HELA_Human1.87989334
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.85507332
26* MITF_21258399_ChIP-Seq_MELANOMA_Human1.79552477
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.79408959
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78071332
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74526144
30ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.70695699
31NR3C1_21868756_ChIP-Seq_MCF10A_Human1.64784356
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.60678090
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.57066260
34CLOCK_20551151_ChIP-Seq_293T_Human1.52835382
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.50333533
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47339836
37* PIAS1_25552417_ChIP-Seq_VCAP_Human1.41956761
38ZNF263_19887448_ChIP-Seq_K562_Human1.41210242
39FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.40647169
40* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39220640
41FUS_26573619_Chip-Seq_HEK293_Human1.37823469
42* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.36616746
43DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.36560232
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35402034
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32240083
46KAP1_22055183_ChIP-Seq_ESCs_Mouse1.32103213
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.30832027
48P300_19829295_ChIP-Seq_ESCs_Human1.28558871
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.27141889
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.26653958
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.26638854
52CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.25125467
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24673156
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23384126
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21994433
56FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.21314018
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20615969
58AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19434710
59BRD4_25478319_ChIP-Seq_HGPS_Human1.19309069
60SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17916268
61SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17916268
62AR_21909140_ChIP-Seq_LNCAP_Human1.17643701
63TP53_18474530_ChIP-ChIP_U2OS_Human1.16586783
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16032456
65TRIM28_21343339_ChIP-Seq_HEK293_Human1.15982911
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15097323
67CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14919758
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14411712
69* TAL1_26923725_Chip-Seq_HPCs_Mouse1.14291619
70FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13608285
71TBX20_22080862_ChIP-Seq_HEART_Mouse1.12999298
72TBX20_22328084_ChIP-Seq_HEART_Mouse1.12999298
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12790072
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12299267
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11786738
76FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11581089
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.10682498
78GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.10573221
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08113930
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06663179
81TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06432544
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.05996416
83SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03894804
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03303997
85P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02582438
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02323438
87FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.01942818
88EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01617564
89SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00806108
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.00628894
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00372675
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00284651
93GATA1_26923725_Chip-Seq_HPCs_Mouse0.99979333
94SOX17_20123909_ChIP-Seq_XEN_Mouse0.99878896
95HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99871678
96BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98935098
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97821711
98ESR2_21235772_ChIP-Seq_MCF-7_Human0.95814031
99UBF1/2_26484160_Chip-Seq_HMECs_Human0.95234534
100ETS1_22383799_ChIP-Seq_G1ME_Mouse0.95001869
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94956758
102JUN_21703547_ChIP-Seq_K562_Human0.94349544
103SOX2_18555785_Chip-Seq_ESCs_Mouse0.92309909
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91700939
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.91626773
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91228716
107PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91056475
108OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90944357
109ELK1_19687146_ChIP-ChIP_HELA_Human0.90333094
110* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89981641
111E2F1_21310950_ChIP-Seq_MCF-7_Human0.89382303
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89376316
113MYCN_18555785_ChIP-Seq_MESCs_Mouse0.89289711
114SOX2_22085726_ChIP-Seq_NPCs_Mouse0.89288500
115* SMAD3_21741376_ChIP-Seq_EPCs_Human0.89179080
116MYB_21317192_ChIP-Seq_ERMYB_Mouse0.88692417
117STAT3_18555785_Chip-Seq_ESCs_Mouse0.88474954
118* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.88028502
119ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87921606
120MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87790545
121P53_22387025_ChIP-Seq_ESCs_Mouse0.87267099
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86802391
123ISL1_27105846_Chip-Seq_CPCs_Mouse0.86236395
124ESRRB_18555785_Chip-Seq_ESCs_Mouse0.86121508
125NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85981868
126NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85981868
127FOXO3_23340844_ChIP-Seq_DLD1_Human0.85571522
128GATA3_24758297_ChIP-Seq_MCF-7_Human0.85278689
129BCAT_22108803_ChIP-Seq_LS180_Human0.84966823
130PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84456376
131MYC_18358816_ChIP-ChIP_MESCs_Mouse0.84257757
132TP53_16413492_ChIP-PET_HCT116_Human0.84108136
133DCP1A_22483619_ChIP-Seq_HELA_Human0.83816214
134EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83712519
135SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83651503
136ATF3_27146783_Chip-Seq_COLON_Human0.82687432
137* CJUN_26792858_Chip-Seq_BT549_Human0.82441382
138TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.82439136
139* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82387362
140PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82157960
141TCF4_23295773_ChIP-Seq_U87_Human0.82148617
142FOXA2_19822575_ChIP-Seq_HepG2_Human0.82098958
143SOX9_24532713_ChIP-Seq_HFSC_Mouse0.81592571
144NMYC_18555785_Chip-Seq_ESCs_Mouse0.81346419
145SMAD4_21799915_ChIP-Seq_A2780_Human0.80727757
146GATA4_21415370_ChIP-Seq_HL-1_Mouse0.80664803
147AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80378193
148PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.80249006
149HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79967155
150KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.79887111
151ZFX_18555785_Chip-Seq_ESCs_Mouse0.79705338
152PU1_27457419_Chip-Seq_LIVER_Mouse0.79277885
153STAT3_23295773_ChIP-Seq_U87_Human0.78729817
154GF1B_26923725_Chip-Seq_HPCs_Mouse0.78698146
155RXR_22158963_ChIP-Seq_LIVER_Mouse0.77596400
156NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.77502554
157PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.76389207
158SALL1_21062744_ChIP-ChIP_HESCs_Human0.76163823
159PPARA_22158963_ChIP-Seq_LIVER_Mouse0.75493731
160KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.75452545
161PU_27001747_Chip-Seq_BMDM_Mouse0.74729805
162PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.70759867
163BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70110033
164* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.69451938
165RUNX1_27514584_Chip-Seq_MCF-7_Human0.69057886
166NFIB_24661679_ChIP-Seq_LUNG_Mouse0.68434727
167GATA2_21666600_ChIP-Seq_HMVEC_Human0.68406738
168SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.67723265
169NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.67267901
170PADI4_21655091_ChIP-ChIP_MCF-7_Human0.66871798
171* AR_25329375_ChIP-Seq_VCAP_Human0.66788650
172LXR_22158963_ChIP-Seq_LIVER_Mouse0.66008598

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation9.65020342
2MP0005408_hypopigmentation6.00812569
3MP0003136_yellow_coat_color5.60998187
4MP0004381_abnormal_hair_follicle4.31336470
5MP0005257_abnormal_intraocular_pressure4.25808576
6* MP0000371_diluted_coat_color3.91469209
7MP0002095_abnormal_skin_pigmentation3.50438996
8MP0002877_abnormal_melanocyte_morpholog3.40232251
9MP0000015_abnormal_ear_pigmentation3.38312692
10MP0005075_abnormal_melanosome_morpholog2.64073397
11* MP0001324_abnormal_eye_pigmentation2.39742812
12* MP0002075_abnormal_coat/hair_pigmentati2.28643667
13MP0005174_abnormal_tail_pigmentation2.20023635
14MP0000569_abnormal_digit_pigmentation2.19936371
15MP0000372_irregular_coat_pigmentation11.7032911
16* MP0001186_pigmentation_phenotype1.82675394
17MP0002938_white_spotting1.81213586
18MP0005248_abnormal_Harderian_gland1.74562871
19MP0003806_abnormal_nucleotide_metabolis1.42326098
20MP0002638_abnormal_pupillary_reflex1.33174812
21MP0002090_abnormal_vision1.26186149
22MP0003705_abnormal_hypodermis_morpholog1.21528227
23MP0005409_darkened_coat_color1.12444053
24MP0003646_muscle_fatigue1.12251470
25MP0003011_delayed_dark_adaptation1.08679250
26* MP0005197_abnormal_uvea_morphology0.91953149
27MP0010234_abnormal_vibrissa_follicle0.83780920
28MP0005253_abnormal_eye_physiology0.81959275
29MP0010094_abnormal_chromosome_stability0.79143912
30MP0000733_abnormal_muscle_development0.71208879
31MP0003453_abnormal_keratinocyte_physiol0.70891701
32MP0001293_anophthalmia0.69755192
33MP0002089_abnormal_postnatal_growth/wei0.65794894
34MP0005058_abnormal_lysosome_morphology0.62453260
35* MP0000367_abnormal_coat/_hair0.56115855
36MP0006054_spinal_hemorrhage0.53600665
37MP0000377_abnormal_hair_follicle0.50845913
38MP0002822_catalepsy0.50789463
39MP0000762_abnormal_tongue_morphology0.50320605
40MP0009697_abnormal_copulation0.50173098
41MP0001485_abnormal_pinna_reflex0.49829588
42MP0010030_abnormal_orbit_morphology0.48902832
43MP0005391_vision/eye_phenotype0.47456189
44MP0002092_abnormal_eye_morphology0.47269121
45MP0010307_abnormal_tumor_latency0.45558100
46MP0006138_congestive_heart_failure0.44808814
47MP0005551_abnormal_eye_electrophysiolog0.44753832
48MP0005023_abnormal_wound_healing0.43879224
49MP0009840_abnormal_foam_cell0.43717138
50MP0002177_abnormal_outer_ear0.42241926
51MP0003566_abnormal_cell_adhesion0.41296307
52MP0008260_abnormal_autophagy0.41192945
53MP0003943_abnormal_hepatobiliary_system0.38114137
54MP0005623_abnormal_meninges_morphology0.37842839
55MP0003186_abnormal_redox_activity0.36974960
56MP0000465_gastrointestinal_hemorrhage0.34817541
57MP0008438_abnormal_cutaneous_collagen0.34205227
58MP0000647_abnormal_sebaceous_gland0.34042533
59MP0003191_abnormal_cellular_cholesterol0.30408150
60MP0001849_ear_inflammation0.29953440
61MP0003091_abnormal_cell_migration0.29936852
62MP0008057_abnormal_DNA_replication0.29932853
63MP0003950_abnormal_plasma_membrane0.28879439
64MP0008770_decreased_survivor_rate0.28829508
65MP0004084_abnormal_cardiac_muscle0.28508321
66MP0000749_muscle_degeneration0.28310774
67MP0002837_dystrophic_cardiac_calcinosis0.27460169
68MP0003077_abnormal_cell_cycle0.27408129
69MP0001958_emphysema0.26721765
70MP0001984_abnormal_olfaction0.26022901
71MP0000358_abnormal_cell_content/0.25741504
72MP0004233_abnormal_muscle_weight0.25019459
73* MP0005193_abnormal_anterior_eye0.24242765
74MP0001915_intracranial_hemorrhage0.23303516
75MP0002396_abnormal_hematopoietic_system0.22330131
76MP0009046_muscle_twitch0.21507000
77MP0001851_eye_inflammation0.20501743
78MP0003567_abnormal_fetal_cardiomyocyte0.20101270
79MP0005451_abnormal_body_composition0.19866852
80MP0003172_abnormal_lysosome_physiology0.19341354
81MP0010352_gastrointestinal_tract_polyps0.19196971
82MP0004197_abnormal_fetal_growth/weight/0.17572426
83MP0001188_hyperpigmentation0.16139983
84MP0003111_abnormal_nucleus_morphology0.15960217
85MP0004484_altered_response_of0.15200023
86MP0002139_abnormal_hepatobiliary_system0.14734376
87MP0002697_abnormal_eye_size0.13582264
88MP0008932_abnormal_embryonic_tissue0.12396332
89MP0004808_abnormal_hematopoietic_stem0.12258560
90MP0003385_abnormal_body_wall0.11731040
91MP0001299_abnormal_eye_distance/0.11598147
92MP0004272_abnormal_basement_membrane0.10068915
93MP0005164_abnormal_response_to0.10065050
94MP0006036_abnormal_mitochondrial_physio0.10058955
95MP0005384_cellular_phenotype0.09962325
96MP0000955_abnormal_spinal_cord0.07991858
97MP0003632_abnormal_nervous_system0.07703280
98MP0002229_neurodegeneration0.07430123
99MP0004147_increased_porphyrin_level0.07355692
100MP0005621_abnormal_cell_physiology0.07131387
101MP0008569_lethality_at_weaning0.06795401
102MP0005195_abnormal_posterior_eye0.06527285
103MP0004134_abnormal_chest_morphology0.06216856
104MP0000920_abnormal_myelination0.06031785
105MP0009703_decreased_birth_body0.05974033
106MP0003938_abnormal_ear_development0.05834777
107MP0000747_muscle_weakness0.05520025
108MP0003755_abnormal_palate_morphology0.05293711
109MP0010678_abnormal_skin_adnexa0.05214256
110MP0000432_abnormal_head_morphology0.05063659
111MP0003937_abnormal_limbs/digits/tail_de0.04998743
112MP0008007_abnormal_cellular_replicative0.04758795
113MP0002269_muscular_atrophy0.04385019
114MP0003045_fibrosis0.04271489
115MP0000427_abnormal_hair_cycle0.03870529
116MP0004036_abnormal_muscle_relaxation0.03683305
117MP0003137_abnormal_impulse_conducting0.03195312
118MP0008058_abnormal_DNA_repair0.03013886
119MP0009384_cardiac_valve_regurgitation0.02959978
120MP0005330_cardiomyopathy0.02875566
121MP0003718_maternal_effect0.02828020
122MP0003634_abnormal_glial_cell0.02680159
123MP0010329_abnormal_lipoprotein_level0.02558587
124MP0002751_abnormal_autonomic_nervous0.02558021
125MP0005187_abnormal_penis_morphology0.01854238
126MP0003300_gastrointestinal_ulcer0.01736151
127MP0005275_abnormal_skin_tensile0.01722483
128MP0002060_abnormal_skin_morphology0.01719532
129MP0004087_abnormal_muscle_fiber0.01266826
130MP0005165_increased_susceptibility_to0.01158409
131MP0003329_amyloid_beta_deposits0.00742442
132MP0000537_abnormal_urethra_morphology0.00585687
133MP0005083_abnormal_biliary_tract0.00130371
134MP0000681_abnormal_thyroid_gland0.00068039
135MP0002128_abnormal_blood_circulation0.00045949
136MP0002752_abnormal_somatic_nervous-0.0011925

Predicted human phenotypes

RankGene SetZ-score
1Hypopigmentation of the fundus (HP:0007894)8.32917501
2* Ocular albinism (HP:0001107)7.71041188
3Generalized hypopigmentation (HP:0007513)7.13366574
4* Iris hypopigmentation (HP:0007730)6.71970951
5White forelock (HP:0002211)6.53003549
6Subacute progressive viral hepatitis (HP:0006572)6.37051820
7Congenital sensorineural hearing impairment (HP:0008527)6.18642939
8Patchy hypopigmentation of hair (HP:0011365)5.83567531
9Hypoplasia of the iris (HP:0007676)5.16001893
10Cutaneous melanoma (HP:0012056)4.74408908
11Heterochromia iridis (HP:0001100)4.64268010
12Generalized hypopigmentation of hair (HP:0011358)4.46750665
13Bilateral sensorineural hearing impairment (HP:0008619)4.09028339
14Aplasia/Hypoplasia affecting the fundus (HP:0008057)3.91216003
15Premature graying of hair (HP:0002216)3.75447388
16Viral hepatitis (HP:0006562)3.63115966
17Micronodular cirrhosis (HP:0001413)3.51601030
18Albinism (HP:0001022)3.36203249
19Hepatocellular carcinoma (HP:0001402)2.98308463
20* Freckling (HP:0001480)2.95754966
21Neoplasm of the adrenal cortex (HP:0100641)2.88993078
22Congenital stationary night blindness (HP:0007642)2.69340511
23Amblyopia (HP:0000646)2.67172741
24Melanoma (HP:0002861)2.48042422
25Horizontal nystagmus (HP:0000666)2.46863209
26Asymmetric septal hypertrophy (HP:0001670)2.34815241
27Abnormality of vision evoked potentials (HP:0000649)2.24431373
28Abnormal auditory evoked potentials (HP:0006958)2.23340838
29Abnormality of glycolipid metabolism (HP:0010969)2.03312517
30Abnormality of liposaccharide metabolism (HP:0010968)2.03312517
31Abnormality of glycosphingolipid metabolism (HP:0004343)2.03312517
32Aplasia/Hypoplasia of the macula (HP:0008059)12.7868036
33Aplasia/Hypoplasia affecting the retina (HP:0008061)11.9790033
34Hypoplasia of the fovea (HP:0007750)11.7930497
35Aplasia/Hypoplasia of the fovea (HP:0008060)11.7930497
36Blue irides (HP:0000635)11.7020752
37Abnormality of the fovea (HP:0000493)10.1297643
38Mucopolysacchariduria (HP:0008155)1.99869135
39Urinary glycosaminoglycan excretion (HP:0003541)1.99869135
40Scapular winging (HP:0003691)1.93910187
41Abnormal gallbladder physiology (HP:0012438)1.93775758
42Cholecystitis (HP:0001082)1.93775758
43Neoplasm of the adrenal gland (HP:0100631)1.90176580
44Degeneration of anterior horn cells (HP:0002398)1.86894393
45Abnormality of the anterior horn cell (HP:0006802)1.86894393
46Choroideremia (HP:0001139)1.85748480
47Renal cell carcinoma (HP:0005584)1.84596181
48Vertebral compression fractures (HP:0002953)1.84069254
49Epidermoid cyst (HP:0200040)1.82253389
50Spastic diplegia (HP:0001264)1.82203043
51Peripheral hypomyelination (HP:0007182)1.81615970
52Frequent falls (HP:0002359)1.81006633
53Rhabdomyosarcoma (HP:0002859)1.79680592
54Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79355194
55Abnormality of polysaccharide metabolism (HP:0011012)1.79355194
56Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79355194
57Synophrys (HP:0000664)1.73782152
58Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71072946
59Astigmatism (HP:0000483)1.68124235
60Underdeveloped nasal alae (HP:0000430)1.65145120
61Melanocytic nevus (HP:0000995)1.62725689
62Tongue fasciculations (HP:0001308)1.62607758
63Hypermelanotic macule (HP:0001034)1.61810911
64Dysostosis multiplex (HP:0000943)1.60168484
65Hepatitis (HP:0012115)1.56179461
66Cerebral hypomyelination (HP:0006808)1.47665456
67Exercise-induced muscle cramps (HP:0003710)1.45856312
68Hypokinesia (HP:0002375)1.44043470
69Facial cleft (HP:0002006)1.42079952
70Tented upper lip vermilion (HP:0010804)1.41730373
71Adrenal hypoplasia (HP:0000835)1.41400739
72Alacrima (HP:0000522)1.40252729
73Intestinal atresia (HP:0011100)1.40162419
74Conjunctival hamartoma (HP:0100780)1.38437473
75Abnormal autonomic nervous system physiology (HP:0012332)1.36994514
76Muscle fibrillation (HP:0010546)1.36921158
77Megalencephaly (HP:0001355)1.35791447
78Abnormality of the pupil (HP:0000615)1.35423221
79Abnormality of the anterior chamber (HP:0000593)1.33368208
80Photophobia (HP:0000613)1.32810585
81Scotoma (HP:0000575)1.31720461
82Hamartoma of the eye (HP:0010568)1.31435346
83Fibular hypoplasia (HP:0003038)1.30673200
84Narrow nasal bridge (HP:0000446)1.30018720
85Cerebral inclusion bodies (HP:0100314)1.27808238
86Protrusio acetabuli (HP:0003179)1.27366245
87Decreased lacrimation (HP:0000633)1.26275017
88Abnormality of the left ventricular outflow tract (HP:0011103)1.26111855
89Subaortic stenosis (HP:0001682)1.26111855
90Aortic aneurysm (HP:0004942)1.25392089
91Neoplasm of the liver (HP:0002896)1.24643535
92Hand muscle atrophy (HP:0009130)1.24469503
93Long toe (HP:0010511)1.24237719
94Aplasia cutis congenita (HP:0001057)1.23785052
95Myelomeningocele (HP:0002475)1.21811485
96Neoplasm of striated muscle (HP:0009728)1.20952548
97Supernumerary ribs (HP:0005815)1.20933621
98Vascular tortuosity (HP:0004948)1.20223114
99Visual hallucinations (HP:0002367)1.19169090
100Anterior segment dysgenesis (HP:0007700)1.18760364
101Decreased central vision (HP:0007663)1.18090649
102Spastic paraplegia (HP:0001258)1.17306340
103Ulnar deviation of finger (HP:0009465)1.16896758
104Poor head control (HP:0002421)1.16295974
105Hypermetropia (HP:0000540)1.14290208
106Intestinal polyposis (HP:0200008)1.13758723
107Morphological abnormality of the inner ear (HP:0011390)1.12193210
108Spinal muscular atrophy (HP:0007269)1.08989984
109Decreased motor nerve conduction velocity (HP:0003431)1.08856743
110Asymmetry of the thorax (HP:0001555)1.07777223
111Atelectasis (HP:0100750)1.06867438
112Overlapping toe (HP:0001845)1.05296788
113Intestinal polyp (HP:0005266)1.04809166
114Coarse hair (HP:0002208)1.04555081
115Macular degeneration (HP:0000608)1.04481881
116Tracheomalacia (HP:0002779)1.04114238
117Loss of speech (HP:0002371)1.03381936
118Paraplegia (HP:0010550)1.03124519
119Synostosis of carpal bones (HP:0005048)1.02760876
120Paraparesis (HP:0002385)1.02688611
121Absent frontal sinuses (HP:0002688)1.02391768
122Upper limb amyotrophy (HP:0009129)1.01918678
123Distal upper limb amyotrophy (HP:0007149)1.01918678
124Supernumerary bones of the axial skeleton (HP:0009144)1.01697748
125Neoplasm of the oral cavity (HP:0100649)0.99497787
126Proximal amyotrophy (HP:0007126)0.99407025
127Bladder diverticulum (HP:0000015)0.99206876
128Abnormality of glycolysis (HP:0004366)0.99063520
129Ovoid vertebral bodies (HP:0003300)0.99057983
130Premature rupture of membranes (HP:0001788)0.98027985
131Abnormality of the shoulder girdle musculature (HP:0001435)0.97660627
132Long clavicles (HP:0000890)0.96830816
133Neoplasm of the colon (HP:0100273)0.96652461
134Parkinsonism with favorable response to dopaminergic medication (HP:0002548)0.96024664
135Distal sensory impairment (HP:0002936)0.94224059
136Large for gestational age (HP:0001520)0.93729206
137Spastic paraparesis (HP:0002313)0.93419091
138Dyschromatopsia (HP:0007641)0.93367922
139Osteolytic defects of the phalanges of the hand (HP:0009771)0.92754766
140Osteolytic defects of the hand bones (HP:0009699)0.92754766
141Uterine leiomyosarcoma (HP:0002891)0.92572379
142Leiomyosarcoma (HP:0100243)0.92572379
143Skin nodule (HP:0200036)0.91494467
144Ulnar deviation of the hand or of fingers of the hand (HP:0001193)0.91330233
145Carpal synostosis (HP:0009702)0.91114096
146Leukodystrophy (HP:0002415)0.91113630
147Upper limb muscle weakness (HP:0003484)0.90006374
148Exostoses (HP:0100777)0.88584905
149Cutaneous finger syndactyly (HP:0010554)0.87712447
150Macroorchidism (HP:0000053)0.86085078
151Hypopigmented skin patches (HP:0001053)0.85461275
152Enlarged penis (HP:0000040)0.85151006
153Bladder neoplasm (HP:0009725)0.84853429
154Bladder carcinoma (HP:0002862)0.84853429
155Attenuation of retinal blood vessels (HP:0007843)0.84671368
156Joint stiffness (HP:0001387)0.84187183
157Deep venous thrombosis (HP:0002625)0.83079122

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MET5.70737858
2PDK24.51539311
3BMX3.99220595
4MARK33.87245269
5PKN23.66749630
6WEE12.96666927
7TRIB32.58649799
8CDK32.34639324
9BMPR22.32091729
10EPHA32.19485923
11ERBB32.12830364
12EIF2AK12.03846949
13MST1R13.3347730
14BMPR1B1.90730021
15TRIM281.88792625
16PRKCH1.86490959
17ACVR1B1.67426771
18SCYL21.58884967
19EIF2AK31.47574328
20SIK31.35974933
21TGFBR21.27189327
22DDR21.21568402
23GRK61.18310761
24PTK2B1.15785422
25GRK51.12589038
26LATS11.05363281
27PLK31.03239727
28MAP3K30.97743186
29NEK60.96000194
30FLT30.92329786
31PTK60.87284482
32PRKD10.85766343
33ABL20.84562481
34PLK10.84300897
35TTN0.82787499
36NEK10.81743223
37PRKD30.78622293
38GSK3A0.77774033
39DAPK30.77743434
40LRRK20.74850249
41MAPKAPK30.72005221
42BRSK10.71889515
43STK38L0.71885876
44ATR0.68417915
45CAMKK10.67226883
46CCNB10.63746877
47CSNK1G10.60769085
48CDK180.58904139
49RET0.58437249
50KSR20.56368719
51CSNK1G30.54061462
52ADRBK10.52175389
53CSNK1A1L0.52171457
54PIM10.51864860
55KSR10.50087114
56RPS6KB10.49654964
57BCR0.49426269
58TGFBR10.49390085
59CDK150.48425943
60FER0.48385572
61MATK0.48103567
62KIT0.47936584
63PAK40.47190847
64ATM0.46864133
65ILK0.42869800
66STK380.42074145
67EIF2AK20.42016317
68CDK11A0.42004401
69FGFR40.41958967
70CDK140.41667293
71CSNK1G20.41621221
72PDGFRA0.41186744
73CAMKK20.39630065
74ICK0.39404989
75RPS6KB20.39402579
76KDR0.39210440
77MAP3K90.38838975
78BUB10.38458256
79TBK10.36218146
80PRKG20.35889841
81RIPK10.34974657
82MAP3K130.33970842
83AKT20.33885913
84DYRK1A0.33586438
85CSNK1A10.32597389
86FRK0.31978866
87EEF2K0.31409258
88PINK10.31146103
89MAPK120.30471243
90PAK60.29419901
91PRKCE0.29070181
92MELK0.27576837
93INSR0.26668933
94PRKCZ0.25787797
95MAP2K10.24859225
96CDK60.24749462
97CDK70.24637257
98PRKD20.23688107
99NTRK10.23172467
100FGFR30.22810473
101CAMK1D0.21951000
102LMTK20.20728439
103EGFR0.20423153
104MAP3K80.20018828
105MAPK70.19458184
106DMPK0.19350273
107MAP3K110.18923883
108PLK40.18519876
109RAF10.18130173
110CAMK2A0.17632101
111NME20.16941327
112STK390.16399857
113CHUK0.16112724
114FGR0.14761052
115EPHB10.13700795
116STK40.13688633
117SGK30.13302127
118ARAF0.13239252
119CDC70.13200912
120IGF1R0.12541547
121TYRO30.12477227
122ALK0.12414549
123TLK10.12157280
124FGFR10.11759277
125PLK20.11609689
126PAK30.11392392
127LATS20.11344123
128RPS6KA10.11242814
129STK30.11208854
130PAK20.11101484
131SGK20.10981761
132FGFR20.10897560
133PDGFRB0.10831943
134ABL10.10626158
135CHEK20.10598719
136SRC0.10505361
137BRSK20.09036007
138PTK20.08731450
139CDK40.08540233
140BLK0.08256993
141MAPK30.08146173
142CSNK1D0.08139296
143DYRK1B0.07460393
144ZAK0.07223221
145MAP4K10.05812506
146MOS0.05681505
147PRKACB0.05438807
148TRPM70.05191701
149SGK4940.05142391
150SGK2230.05142391
151MAP3K20.04269014
152PRKAA20.04168779
153NEK90.03543755
154PRKCQ0.03477866
155PDK10.03212764
156MAP3K10.02615976
157ERBB20.02468828
158NEK20.01939623
159WNK40.01667168

Predicted pathways (KEGG)

RankGene SetZ-score
1* Tyrosine metabolism_Homo sapiens_hsa003507.96634349
2Glycosaminoglycan degradation_Homo sapiens_hsa005314.66154560
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.13538239
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.45126288
5* Melanogenesis_Homo sapiens_hsa049163.24261159
6Non-homologous end-joining_Homo sapiens_hsa034503.19948071
7Central carbon metabolism in cancer_Homo sapiens_hsa052303.10317167
8Galactose metabolism_Homo sapiens_hsa000522.57453351
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.43904995
10Melanoma_Homo sapiens_hsa052182.27288470
11Renal cell carcinoma_Homo sapiens_hsa052112.24910552
12Other glycan degradation_Homo sapiens_hsa005112.22669594
13Proteasome_Homo sapiens_hsa030502.09590689
14Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.07835531
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.07442054
16Fatty acid elongation_Homo sapiens_hsa000621.94512226
17Protein export_Homo sapiens_hsa030601.94384163
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93617724
19p53 signaling pathway_Homo sapiens_hsa041151.83990240
20Sphingolipid metabolism_Homo sapiens_hsa006001.82353273
21Adherens junction_Homo sapiens_hsa045201.71644938
22Histidine metabolism_Homo sapiens_hsa003401.65758744
23Homologous recombination_Homo sapiens_hsa034401.62593773
24Starch and sucrose metabolism_Homo sapiens_hsa005001.61666828
25Biosynthesis of amino acids_Homo sapiens_hsa012301.57572149
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54731038
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.51633571
28Oxidative phosphorylation_Homo sapiens_hsa001901.50335612
29Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.49763392
30Cell cycle_Homo sapiens_hsa041101.47962430
31Fructose and mannose metabolism_Homo sapiens_hsa000511.47428422
32Systemic lupus erythematosus_Homo sapiens_hsa053221.37960236
33beta-Alanine metabolism_Homo sapiens_hsa004101.36289619
34Glutathione metabolism_Homo sapiens_hsa004801.34059241
35Malaria_Homo sapiens_hsa051441.32470658
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.29450068
37Parkinsons disease_Homo sapiens_hsa050121.26650758
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23504547
39Carbon metabolism_Homo sapiens_hsa012001.18346232
40Mismatch repair_Homo sapiens_hsa034301.17906933
41HIF-1 signaling pathway_Homo sapiens_hsa040661.17530450
42One carbon pool by folate_Homo sapiens_hsa006701.16874748
43Pentose phosphate pathway_Homo sapiens_hsa000301.14808808
44Vibrio cholerae infection_Homo sapiens_hsa051101.14517452
45N-Glycan biosynthesis_Homo sapiens_hsa005101.14148477
46Pyruvate metabolism_Homo sapiens_hsa006201.13567395
47Lysosome_Homo sapiens_hsa041421.12088791
48Fanconi anemia pathway_Homo sapiens_hsa034601.09689652
49Collecting duct acid secretion_Homo sapiens_hsa049661.02460618
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98733333
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98252510
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98071873
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97313403
54MicroRNAs in cancer_Homo sapiens_hsa052060.96705827
55Glioma_Homo sapiens_hsa052140.94946201
56Proteoglycans in cancer_Homo sapiens_hsa052050.94704033
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94190081
58Focal adhesion_Homo sapiens_hsa045100.91873065
59Alzheimers disease_Homo sapiens_hsa050100.89260582
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86119944
61Axon guidance_Homo sapiens_hsa043600.84967685
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84694561
63Alcoholism_Homo sapiens_hsa050340.82432921
64Small cell lung cancer_Homo sapiens_hsa052220.82131751
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80394230
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78241674
67Chronic myeloid leukemia_Homo sapiens_hsa052200.78035043
68mTOR signaling pathway_Homo sapiens_hsa041500.77998291
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77007935
70Folate biosynthesis_Homo sapiens_hsa007900.74425230
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73162885
72Butanoate metabolism_Homo sapiens_hsa006500.72950080
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71040792
74Steroid biosynthesis_Homo sapiens_hsa001000.70673466
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.69603324
76Bile secretion_Homo sapiens_hsa049760.69570852
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69102279
78Thyroid cancer_Homo sapiens_hsa052160.67258703
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67248731
80* Metabolic pathways_Homo sapiens_hsa011000.67190020
81Estrogen signaling pathway_Homo sapiens_hsa049150.65946635
82Huntingtons disease_Homo sapiens_hsa050160.65587805
83Phenylalanine metabolism_Homo sapiens_hsa003600.64220458
84Viral carcinogenesis_Homo sapiens_hsa052030.62226138
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59246677
86Bladder cancer_Homo sapiens_hsa052190.58413163
87Fat digestion and absorption_Homo sapiens_hsa049750.57894665
88VEGF signaling pathway_Homo sapiens_hsa043700.56376976
89DNA replication_Homo sapiens_hsa030300.55834396
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55401917
91Prolactin signaling pathway_Homo sapiens_hsa049170.54537881
92Insulin signaling pathway_Homo sapiens_hsa049100.54123074
93Glucagon signaling pathway_Homo sapiens_hsa049220.54059718
94Lysine degradation_Homo sapiens_hsa003100.54043214
95Endometrial cancer_Homo sapiens_hsa052130.53086261
96Fatty acid degradation_Homo sapiens_hsa000710.52471744
97Prostate cancer_Homo sapiens_hsa052150.52459387
98Linoleic acid metabolism_Homo sapiens_hsa005910.51867141
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51462050
100Retinol metabolism_Homo sapiens_hsa008300.49466127
101Rap1 signaling pathway_Homo sapiens_hsa040150.49369802
102Osteoclast differentiation_Homo sapiens_hsa043800.48387552
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47685100
104ABC transporters_Homo sapiens_hsa020100.47020136
105Inositol phosphate metabolism_Homo sapiens_hsa005620.46881395
106Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46331345
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46146464
108ErbB signaling pathway_Homo sapiens_hsa040120.45828805
109FoxO signaling pathway_Homo sapiens_hsa040680.45572069
110Vitamin B6 metabolism_Homo sapiens_hsa007500.45269825
111Nucleotide excision repair_Homo sapiens_hsa034200.44661771
112Endocytosis_Homo sapiens_hsa041440.44494169
113Chemical carcinogenesis_Homo sapiens_hsa052040.44028961
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43991393
115Ras signaling pathway_Homo sapiens_hsa040140.42170754
116Fatty acid metabolism_Homo sapiens_hsa012120.40457725
117Tight junction_Homo sapiens_hsa045300.37468815
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37065991
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.36646865
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34830163
121Fatty acid biosynthesis_Homo sapiens_hsa000610.32237626
122Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31820994
123Synaptic vesicle cycle_Homo sapiens_hsa047210.31377370
124Hippo signaling pathway_Homo sapiens_hsa043900.31319415
125Arginine biosynthesis_Homo sapiens_hsa002200.30264939
126Phagosome_Homo sapiens_hsa041450.29971267
127Insulin resistance_Homo sapiens_hsa049310.27756967
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27575926
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27377365
130Hepatitis B_Homo sapiens_hsa051610.26584920
131Peroxisome_Homo sapiens_hsa041460.26487658
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26230015
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25746684
134Dorso-ventral axis formation_Homo sapiens_hsa043200.24135441
135Sulfur relay system_Homo sapiens_hsa041220.24001063
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23908440
137Pathways in cancer_Homo sapiens_hsa052000.23759741
138Colorectal cancer_Homo sapiens_hsa052100.23580338
139Propanoate metabolism_Homo sapiens_hsa006400.23574390
140Sulfur metabolism_Homo sapiens_hsa009200.23198241
141Non-small cell lung cancer_Homo sapiens_hsa052230.22882779
142AMPK signaling pathway_Homo sapiens_hsa041520.21884716
143Oocyte meiosis_Homo sapiens_hsa041140.21421068
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21199458
145Thyroid hormone synthesis_Homo sapiens_hsa049180.20924777
146PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20239467
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20173860
148Vascular smooth muscle contraction_Homo sapiens_hsa042700.18130911
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17120708
150Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.16836550
151Mineral absorption_Homo sapiens_hsa049780.15636376
152Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.15244226
153Adipocytokine signaling pathway_Homo sapiens_hsa049200.14565943
154cGMP-PKG signaling pathway_Homo sapiens_hsa040220.13628210

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