TYSND1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix. The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative splicing results in multiple transcript variants for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.50378699
2L-phenylalanine metabolic process (GO:0006558)6.50378699
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.50069121
4L-phenylalanine catabolic process (GO:0006559)6.50069121
5aromatic amino acid family catabolic process (GO:0009074)5.76343611
6glyoxylate metabolic process (GO:0046487)5.64887902
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.63186543
8cysteine metabolic process (GO:0006534)5.35462948
9alpha-linolenic acid metabolic process (GO:0036109)5.35143678
10sulfur amino acid catabolic process (GO:0000098)5.24947025
11kynurenine metabolic process (GO:0070189)5.15526298
12indole-containing compound catabolic process (GO:0042436)5.11745913
13indolalkylamine catabolic process (GO:0046218)5.11745913
14tryptophan catabolic process (GO:0006569)5.11745913
15bile acid biosynthetic process (GO:0006699)5.10781468
16lysine metabolic process (GO:0006553)5.00609238
17lysine catabolic process (GO:0006554)5.00609238
18serine family amino acid catabolic process (GO:0009071)4.93498448
19urea metabolic process (GO:0019627)4.85385696
20urea cycle (GO:0000050)4.85385696
21negative regulation of fibrinolysis (GO:0051918)4.79839455
22glycine metabolic process (GO:0006544)4.79350895
23tryptophan metabolic process (GO:0006568)4.78173305
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.77710976
25high-density lipoprotein particle remodeling (GO:0034375)4.71096016
26amino-acid betaine metabolic process (GO:0006577)4.62680127
27nitrogen cycle metabolic process (GO:0071941)4.54510168
28amyloid precursor protein catabolic process (GO:0042987)4.53699941
29serine family amino acid biosynthetic process (GO:0009070)4.50305199
30serine family amino acid metabolic process (GO:0009069)4.50246770
31regulation of triglyceride catabolic process (GO:0010896)4.46054495
32protein carboxylation (GO:0018214)4.45313676
33peptidyl-glutamic acid carboxylation (GO:0017187)4.45313676
34regulation of fibrinolysis (GO:0051917)4.41923343
35regulation of protein activation cascade (GO:2000257)4.35513782
36complement activation, alternative pathway (GO:0006957)4.31152522
37ribosomal small subunit biogenesis (GO:0042274)4.30551452
38bile acid metabolic process (GO:0008206)4.30107642
39proline biosynthetic process (GO:0006561)4.27661798
40homocysteine metabolic process (GO:0050667)4.24858262
41GDP-mannose metabolic process (GO:0019673)4.22316375
42alpha-amino acid catabolic process (GO:1901606)4.22009832
43aromatic amino acid family metabolic process (GO:0009072)4.21175065
44negative regulation of sterol transport (GO:0032372)4.15754568
45negative regulation of cholesterol transport (GO:0032375)4.15754568
46reverse cholesterol transport (GO:0043691)4.15034804
47triglyceride homeostasis (GO:0070328)4.09274007
48acylglycerol homeostasis (GO:0055090)4.09274007
49regulation of cholesterol esterification (GO:0010872)4.08772378
50regulation of complement activation (GO:0030449)4.08206915
51plasma lipoprotein particle remodeling (GO:0034369)4.06152601
52protein-lipid complex remodeling (GO:0034368)4.06152601
53macromolecular complex remodeling (GO:0034367)4.06152601
54valine metabolic process (GO:0006573)4.03521068
55plasma lipoprotein particle clearance (GO:0034381)4.02749729
56ethanol oxidation (GO:0006069)3.99531885
57cellular ketone body metabolic process (GO:0046950)3.99078452
58cellular amino acid catabolic process (GO:0009063)3.98415138
59regulation of mitochondrial translation (GO:0070129)3.97776570
60phospholipid efflux (GO:0033700)3.94501523
61cellular modified amino acid catabolic process (GO:0042219)3.94475243
62regulation of translational fidelity (GO:0006450)3.89240556
63coenzyme catabolic process (GO:0009109)3.89128356
642-oxoglutarate metabolic process (GO:0006103)3.88718455
65acetyl-CoA metabolic process (GO:0006084)3.85916194
66tyrosine metabolic process (GO:0006570)3.81998487
67fatty acid beta-oxidation (GO:0006635)3.79920493
68carnitine metabolic process (GO:0009437)3.78305628
69amine catabolic process (GO:0009310)3.76298781
70cellular biogenic amine catabolic process (GO:0042402)3.76298781
71peptidyl-arginine omega-N-methylation (GO:0035247)3.76188562
72short-chain fatty acid metabolic process (GO:0046459)3.74539100
73L-serine metabolic process (GO:0006563)3.73257116
74regulation of cholesterol homeostasis (GO:2000188)3.68992726
75aspartate family amino acid catabolic process (GO:0009068)3.65495698
76fatty acid oxidation (GO:0019395)3.64913583
77carboxylic acid catabolic process (GO:0046395)3.63486094
78organic acid catabolic process (GO:0016054)3.63486094
79plasma lipoprotein particle assembly (GO:0034377)3.62511205
80glutamate metabolic process (GO:0006536)3.61810032
81urate metabolic process (GO:0046415)3.61710769
82viral transcription (GO:0019083)3.60408863
83benzene-containing compound metabolic process (GO:0042537)3.59002146
84imidazole-containing compound metabolic process (GO:0052803)3.57887260
85mitotic G1 DNA damage checkpoint (GO:0031571)3.57654528
86lipid oxidation (GO:0034440)3.57163191
87fatty acid catabolic process (GO:0009062)3.56889263
88bile acid and bile salt transport (GO:0015721)3.53275675
89monocarboxylic acid catabolic process (GO:0072329)3.52550868
90folic acid metabolic process (GO:0046655)3.52469690
91positive regulation of triglyceride lipase activity (GO:0061365)3.51999132
92positive regulation of lipoprotein lipase activity (GO:0051006)3.51999132
93indolalkylamine metabolic process (GO:0006586)3.48786937
94positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.48132839
95aldehyde catabolic process (GO:0046185)3.47912496
96arginine metabolic process (GO:0006525)3.47233485
97amyloid precursor protein metabolic process (GO:0042982)3.47087748
98snRNA metabolic process (GO:0016073)3.45221074
99positive regulation of triglyceride metabolic process (GO:0090208)3.43158306
100regulation of mammary gland epithelial cell proliferation (GO:0033599)3.43078052
101ketone body metabolic process (GO:1902224)3.42762148
102cholesterol efflux (GO:0033344)3.41551579
103positive regulation of lipid catabolic process (GO:0050996)3.39243743
104cellular glucuronidation (GO:0052695)3.38779444
105cofactor catabolic process (GO:0051187)3.38326447
106pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.36874137
107drug transmembrane transport (GO:0006855)3.36493610
108cholesterol homeostasis (GO:0042632)3.34446001
109positive regulation of fatty acid beta-oxidation (GO:0032000)3.34328894
110tricarboxylic acid metabolic process (GO:0072350)3.33281926
111regulation of cholesterol metabolic process (GO:0090181)3.32584365
112blood coagulation, intrinsic pathway (GO:0007597)3.31982066
113deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.31925940
114translational termination (GO:0006415)3.31849575
115protein-lipid complex assembly (GO:0065005)3.31642330
116drug catabolic process (GO:0042737)3.31588937
117sterol homeostasis (GO:0055092)3.28620816
118pentose metabolic process (GO:0019321)3.24343485
119translational elongation (GO:0006414)3.23978880
120rRNA transcription (GO:0009303)3.23270006
121T cell apoptotic process (GO:0070231)3.22381513
122mitotic G1/S transition checkpoint (GO:0044819)3.22299182
123maturation of SSU-rRNA (GO:0030490)3.17488509
124DNA replication checkpoint (GO:0000076)3.16891078
125negative regulation of viral release from host cell (GO:1902187)3.16578477
126G1 DNA damage checkpoint (GO:0044783)3.14679994
127guanosine-containing compound biosynthetic process (GO:1901070)3.13487737
128pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.11587444
129negative regulation of cell size (GO:0045792)3.10100786
130pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.07915228
131peptidyl-arginine methylation (GO:0018216)3.07351247
132peptidyl-arginine N-methylation (GO:0035246)3.07351247
133positive regulation of histone deacetylation (GO:0031065)3.07265159
134UTP biosynthetic process (GO:0006228)3.05681012
135histone arginine methylation (GO:0034969)3.04708903
136CTP biosynthetic process (GO:0006241)3.03929161
137CTP metabolic process (GO:0046036)3.03929161
138apoptotic process involved in morphogenesis (GO:0060561)3.03182011
139regulation of chromatin binding (GO:0035561)3.02084104
140telomere maintenance via semi-conservative replication (GO:0032201)3.01577402
141proline metabolic process (GO:0006560)3.00762342
142nucleotide salvage (GO:0043173)2.98448580
143formation of translation preinitiation complex (GO:0001731)2.97711097
144negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.97194455
145positive regulation of keratinocyte differentiation (GO:0045618)2.93038648
146snRNA processing (GO:0016180)2.92177525
147tRNA methylation (GO:0030488)2.91418253
148positive regulation of Cdc42 GTPase activity (GO:0043089)2.88895597
149peptidyl-histidine modification (GO:0018202)2.88784562
150necroptotic process (GO:0070266)2.87218084
151GMP metabolic process (GO:0046037)2.85608388
152pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.85541852
153spliceosomal tri-snRNP complex assembly (GO:0000244)2.83565400
154biotin metabolic process (GO:0006768)2.83243170
155nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.82545946
156regulation of water loss via skin (GO:0033561)2.80885455
157base-excision repair, AP site formation (GO:0006285)2.77815407
158DNA replication initiation (GO:0006270)2.76536390
159viral life cycle (GO:0019058)2.76088986
160positive regulation of protein deacetylation (GO:0090312)2.75560775
161negative regulation of B cell apoptotic process (GO:0002903)2.74078192
162lymphocyte apoptotic process (GO:0070227)2.73767456
163UTP metabolic process (GO:0046051)2.73591438
164misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.72754660
165pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.71659097
166DNA strand elongation involved in DNA replication (GO:0006271)2.71100528
167ribonucleoprotein complex biogenesis (GO:0022613)2.70672457
168programmed necrotic cell death (GO:0097300)2.70253730
169ribosomal small subunit assembly (GO:0000028)2.69978498
170tRNA modification (GO:0006400)2.69047129
171purine deoxyribonucleotide catabolic process (GO:0009155)2.68689766
172glucose catabolic process (GO:0006007)2.68334518
173pentose-phosphate shunt (GO:0006098)2.67039041
174DNA strand elongation (GO:0022616)2.66692187
175pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.65706163
176cytochrome complex assembly (GO:0017004)2.64082807
177mitotic chromosome condensation (GO:0007076)2.63669611
178pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.61035903
179UMP biosynthetic process (GO:0006222)2.61035903
180pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.61035903
181UMP metabolic process (GO:0046049)2.61035903
182ribosome biogenesis (GO:0042254)2.60248157
183SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.57383703
184mitochondrial DNA metabolic process (GO:0032042)2.56815213
185pyrimidine-containing compound salvage (GO:0008655)2.56657307
186pyrimidine nucleoside salvage (GO:0043097)2.56657307
187base-excision repair (GO:0006284)2.56458282
188GTP biosynthetic process (GO:0006183)2.56409536
189pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.56321277
190respiratory chain complex IV assembly (GO:0008535)2.54715001
191pseudouridine synthesis (GO:0001522)2.54400984
192telomere maintenance via recombination (GO:0000722)2.53703064
193nuclear envelope reassembly (GO:0031468)2.53612825
194mitotic nuclear envelope reassembly (GO:0007084)2.53612825
195NIK/NF-kappaB signaling (GO:0038061)2.53094660
196establishment of skin barrier (GO:0061436)2.51529689
197pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.51363502
198protein targeting to ER (GO:0045047)2.50321534
199ncRNA 3-end processing (GO:0043628)2.48223730
200nucleoside salvage (GO:0043174)2.46822763

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.94776628
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.15183610
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.52437852
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.36358287
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.52035653
6* LXR_22158963_ChIP-Seq_LIVER_Mouse4.45382915
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.91199256
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.55642918
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.19246634
10E2F7_22180533_ChIP-Seq_HELA_Human3.11056286
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.81003792
12* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.50492915
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.45688405
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.45236384
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.26703018
16DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.08014585
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.01849424
18* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.88618611
19CLOCK_20551151_ChIP-Seq_293T_Human1.82438963
20KDM5A_27292631_Chip-Seq_BREAST_Human1.72918403
21THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72088483
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.63333557
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63231189
24ZNF263_19887448_ChIP-Seq_K562_Human1.62663729
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.57315235
26* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56895622
27CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52852577
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51953836
29* SA1_27219007_Chip-Seq_ERYTHROID_Human1.50366809
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47247611
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46061750
32STAT3_1855785_ChIP-Seq_MESCs_Mouse1.45248296
33* KDM2B_26808549_Chip-Seq_DND41_Human1.42730150
34CIITA_25753668_ChIP-Seq_RAJI_Human1.42613753
35* MYC_22102868_ChIP-Seq_BL_Human1.40162253
36CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37769453
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.36753301
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.36092880
39VDR_21846776_ChIP-Seq_THP-1_Human1.35127736
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34692924
41LXR_22292898_ChIP-Seq_THP-1_Human1.34265067
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33189059
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32687658
44CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30744566
45SMC4_20622854_ChIP-Seq_HELA_Human1.28843788
46* FOXP1_21924763_ChIP-Seq_HESCs_Human1.28658339
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28382519
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25743678
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25516882
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24774877
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.22500552
52VDR_24763502_ChIP-Seq_THP-1_Human1.22020784
53FOXP3_21729870_ChIP-Seq_TREG_Human1.21601411
54CTCF_18555785_ChIP-Seq_MESCs_Mouse1.21159511
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21020454
56* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19909134
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.18537159
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18290486
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16103778
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.16035594
61E2F1_20622854_ChIP-Seq_HELA_Human1.15744206
62* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15456011
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14719958
64EST1_17652178_ChIP-ChIP_JURKAT_Human1.10595907
65GATA1_22025678_ChIP-Seq_K562_Human1.10217813
66* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09551458
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09520474
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09069073
69CREB1_26743006_Chip-Seq_LNCaP_Human1.08993670
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.08293301
71* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07655834
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07505826
73* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07504967
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07359425
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07302254
76PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06957601
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06262763
78STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05975585
79RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05799055
80TTF2_22483619_ChIP-Seq_HELA_Human1.05174783
81* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04726305
82SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01831485
83GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01204417
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99354089
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98574443
86* HNF4A_19822575_ChIP-Seq_HepG2_Human0.95273020
87SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94517159
88E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94454777
89BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94273681
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92841654
91RACK7_27058665_Chip-Seq_MCF-7_Human0.90568474
92TET1_21451524_ChIP-Seq_MESCs_Mouse0.89714861
93* BCL6_27268052_Chip-Seq_Bcells_Human0.89549574
94* BCOR_27268052_Chip-Seq_Bcells_Human0.89397840
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89003624
96ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89003624
97NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.88105056
98ELF1_17652178_ChIP-ChIP_JURKAT_Human0.88043864
99ATF3_27146783_Chip-Seq_COLON_Human0.87710104
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86623532
101P68_20966046_ChIP-Seq_HELA_Human0.86302303
102RARA_24833708_ChIP-Seq_LIVER_Mouse0.86111846
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85664805
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85583715
105RARB_24833708_ChIP-Seq_LIVER_Mouse0.84845093
106SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84796518
107FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84168592
108SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.83943949
109E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.83520358
110ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83414548
111SCL_19346495_ChIP-Seq_HPC-7_Human0.83050846
112TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.82878442
113E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.82706570
114FOXA2_19822575_ChIP-Seq_HepG2_Human0.82366120
115* XRN2_22483619_ChIP-Seq_HELA_Human0.82262444
116* CTCF_21964334_Chip-Seq_Bcells_Human0.82083817
117IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.81270135
118ETS1_20019798_ChIP-Seq_JURKAT_Human0.80493226
119MYC_19030024_ChIP-ChIP_MESCs_Mouse0.79590662
120TCF7_22412390_ChIP-Seq_EML_Mouse0.78581689
121AR_21909140_ChIP-Seq_LNCAP_Human0.78289579
122BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77600034
123MAF_26560356_Chip-Seq_TH1_Human0.77457920
124GABP_19822575_ChIP-Seq_HepG2_Human0.77442756
125* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.77081450
126ELF1_20517297_ChIP-Seq_JURKAT_Human0.76645038
127DCP1A_22483619_ChIP-Seq_HELA_Human0.76624023
128SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.76377133
129CREB1_15753290_ChIP-ChIP_HEK293T_Human0.76310028
130* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.76146278
131GATA1_19941827_ChIP-Seq_MEL_Mouse0.76089779
132CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75798649
133FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.75681110
134ESR1_15608294_ChIP-ChIP_MCF-7_Human0.75513922
135HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75299391
136KLF4_18555785_ChIP-Seq_MESCs_Mouse0.73117982
137UTX_26944678_Chip-Seq_JUKART_Human0.72201401
138* MAF_26560356_Chip-Seq_TH2_Human0.71868408
139* CTCF_26484167_Chip-Seq_Bcells_Mouse0.71867653
140GATA2_22383799_ChIP-Seq_G1ME_Mouse0.71569509
141* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.70847593
142PHF8_20622854_ChIP-Seq_HELA_Human0.70736208
143GATA4_25053715_ChIP-Seq_YYC3_Human0.70656398
144* P300_27268052_Chip-Seq_Bcells_Human0.69708387
145TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.69016487

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.18853065
2MP0005360_urolithiasis6.87390344
3MP0005365_abnormal_bile_salt5.56261317
4MP0005085_abnormal_gallbladder_physiolo5.42363105
5MP0003806_abnormal_nucleotide_metabolis4.37002552
6MP0008875_abnormal_xenobiotic_pharmacok4.16509022
7MP0009840_abnormal_foam_cell3.62305442
8MP0010329_abnormal_lipoprotein_level3.35009915
9MP0003252_abnormal_bile_duct3.17902554
10MP0003693_abnormal_embryo_hatching3.09351196
11MP0005083_abnormal_biliary_tract3.01496727
12MP0005332_abnormal_amino_acid2.81366691
13MP0004381_abnormal_hair_follicle2.79804701
14MP0001666_abnormal_nutrient_absorption2.71543861
15MP0002796_impaired_skin_barrier2.66082805
16MP0003191_abnormal_cellular_cholesterol2.44317616
17MP0010234_abnormal_vibrissa_follicle2.41600121
18MP0005501_abnormal_skin_physiology2.33246844
19MP0003195_calcinosis2.26858796
20MP0010030_abnormal_orbit_morphology2.26754637
21MP0000609_abnormal_liver_physiology2.22908369
22MP0003111_abnormal_nucleus_morphology2.20376360
23MP0001873_stomach_inflammation2.18516770
24MP0010094_abnormal_chromosome_stability2.15662540
25MP0005670_abnormal_white_adipose2.10824277
26MP0000678_abnormal_parathyroid_gland2.08840056
27MP0003763_abnormal_thymus_physiology2.04477286
28MP0002118_abnormal_lipid_homeostasis2.03177930
29MP0005319_abnormal_enzyme/_coenzyme1.94448406
30MP0004019_abnormal_vitamin_homeostasis1.93525809
31MP0009333_abnormal_splenocyte_physiolog1.90159243
32MP0003705_abnormal_hypodermis_morpholog1.85497288
33MP0002249_abnormal_larynx_morphology1.84472210
34MP0003186_abnormal_redox_activity1.81227786
35MP0002396_abnormal_hematopoietic_system1.80492798
36MP0004957_abnormal_blastocyst_morpholog1.77613660
37MP0005451_abnormal_body_composition1.71073861
38MP0005584_abnormal_enzyme/coenzyme_acti1.65791979
39MP0009643_abnormal_urine_homeostasis1.63726624
40MP0002138_abnormal_hepatobiliary_system1.61654209
41MP0008058_abnormal_DNA_repair1.60815513
42MP0003077_abnormal_cell_cycle1.60282397
43MP0003656_abnormal_erythrocyte_physiolo1.57852431
44MP0001764_abnormal_homeostasis1.57232138
45MP0003453_abnormal_keratinocyte_physiol1.56136936
46MP0005075_abnormal_melanosome_morpholog1.55991705
47MP0000490_abnormal_crypts_of1.55456967
48MP0005076_abnormal_cell_differentiation1.50516921
49MP0002234_abnormal_pharynx_morphology1.50330253
50MP0003868_abnormal_feces_composition1.48214206
51MP0001849_ear_inflammation1.47446748
52MP0000537_abnormal_urethra_morphology1.45655813
53MP0000003_abnormal_adipose_tissue1.44011864
54MP0000598_abnormal_liver_morphology1.38153874
55MP0002166_altered_tumor_susceptibility1.38150312
56MP0006036_abnormal_mitochondrial_physio1.37930847
57MP0002163_abnormal_gland_morphology1.37802349
58MP0003786_premature_aging1.31255256
59MP0000703_abnormal_thymus_morphology1.29288949
60MP0001346_abnormal_lacrimal_gland1.25224073
61MP0001216_abnormal_epidermal_layer1.21121919
62MP0002098_abnormal_vibrissa_morphology1.19514697
63MP0000566_synostosis1.19325753
64MP0004858_abnormal_nervous_system1.17650598
65MP0003123_paternal_imprinting1.13367134
66MP0008932_abnormal_embryonic_tissue1.11713650
67MP0005636_abnormal_mineral_homeostasis1.09824105
68MP0004782_abnormal_surfactant_physiolog1.09242945
69MP0008260_abnormal_autophagy1.08898064
70MP0005666_abnormal_adipose_tissue1.08735886
71MP0002019_abnormal_tumor_incidence1.06803885
72MP0008469_abnormal_protein_level1.06145578
73MP0002009_preneoplasia1.04739724
74MP0005220_abnormal_exocrine_pancreas1.02670067
75MP0002398_abnormal_bone_marrow1.02395546
76MP0003011_delayed_dark_adaptation1.01656775
77MP0000313_abnormal_cell_death1.00050870
78MP0000350_abnormal_cell_proliferation0.99312038
79MP0009931_abnormal_skin_appearance0.98238749
80MP0009763_increased_sensitivity_to0.97232436
81MP0000377_abnormal_hair_follicle0.97134152
82MP0005377_hearing/vestibular/ear_phenot0.96999895
83MP0003878_abnormal_ear_physiology0.96999895
84MP0004130_abnormal_muscle_cell0.96337766
85MP0008057_abnormal_DNA_replication0.95719766
86MP0009278_abnormal_bone_marrow0.95659153
87MP0000613_abnormal_salivary_gland0.95314730
88MP0004808_abnormal_hematopoietic_stem0.93492392
89MP0002006_tumorigenesis0.92999150
90MP0000467_abnormal_esophagus_morphology0.92955658
91MP0005310_abnormal_salivary_gland0.92364195
92MP0009642_abnormal_blood_homeostasis0.92210803
93MP0003315_abnormal_perineum_morphology0.91667965
94MP0010771_integument_phenotype0.90530288
95MP0000604_amyloidosis0.90409896
96MP0001800_abnormal_humoral_immune0.90335512
97MP0002971_abnormal_brown_adipose0.89850343
98MP0005647_abnormal_sex_gland0.88501274
99MP0005084_abnormal_gallbladder_morpholo0.88416014
100MP0001730_embryonic_growth_arrest0.87662520
101MP0002722_abnormal_immune_system0.86845792
102MP0002429_abnormal_blood_cell0.86651301
103MP0005334_abnormal_fat_pad0.85582382
104MP0000681_abnormal_thyroid_gland0.85555531
105MP0002078_abnormal_glucose_homeostasis0.85234995
106MP0001919_abnormal_reproductive_system0.84123115
107MP0005464_abnormal_platelet_physiology0.84073970
108MP0002277_abnormal_respiratory_mucosa0.82958035
109MP0000477_abnormal_intestine_morphology0.82713924
110MP0000579_abnormal_nail_morphology0.82169300
111MP0000470_abnormal_stomach_morphology0.81355665
112MP0005058_abnormal_lysosome_morphology0.80213681
113MP0000716_abnormal_immune_system0.80134430
114MP0009764_decreased_sensitivity_to0.79378325
115MP0002060_abnormal_skin_morphology0.79338780
116MP0001348_abnormal_lacrimal_gland0.78916633
117MP0004233_abnormal_muscle_weight0.78605176
118MP0001835_abnormal_antigen_presentation0.78398523
119MP0002420_abnormal_adaptive_immunity0.77310226
120MP0001756_abnormal_urination0.77155202
121MP0001853_heart_inflammation0.77151318
122MP0001819_abnormal_immune_cell0.77026428
123MP0005379_endocrine/exocrine_gland_phen0.76865634
124MP0002089_abnormal_postnatal_growth/wei0.76747290
125MP0005376_homeostasis/metabolism_phenot0.76415909
126MP0001661_extended_life_span0.76065674
127MP0000858_altered_metastatic_potential0.75917218
128MP0004264_abnormal_extraembryonic_tissu0.75735723
129MP0005266_abnormal_metabolism0.75651162
130MP0009697_abnormal_copulation0.74590756
131MP0003436_decreased_susceptibility_to0.71162663
132MP0002136_abnormal_kidney_physiology0.70926624
133MP0002970_abnormal_white_adipose0.70246135
134MP0009765_abnormal_xenobiotic_induced0.67854276
135MP0006035_abnormal_mitochondrial_morpho0.64863458
136MP0000685_abnormal_immune_system0.62599383
137MP0003300_gastrointestinal_ulcer0.60609904
138MP0009115_abnormal_fat_cell0.58746823
139MP0005408_hypopigmentation0.57309198
140MP0010368_abnormal_lymphatic_system0.57303909
141MP0004147_increased_porphyrin_level0.55877748
142MP0008873_increased_physiological_sensi0.55873909
143MP0009672_abnormal_birth_weight0.55521948
144MP0003638_abnormal_response/metabolism_0.54534800
145MP0005375_adipose_tissue_phenotype0.54493418
146MP0005535_abnormal_body_temperature0.54259504
147MP0005448_abnormal_energy_balance0.52652495
148MP0001845_abnormal_inflammatory_respons0.51844372
149MP0003329_amyloid_beta_deposits0.51641824
150MP0002132_abnormal_respiratory_system0.50385853
151MP0004185_abnormal_adipocyte_glucose0.50237056
152MP0005023_abnormal_wound_healing0.49403549
153MP0003959_abnormal_lean_body0.48533143
154MP0005330_cardiomyopathy0.44445885
155MP0004947_skin_inflammation0.44350814
156MP0002269_muscular_atrophy0.44028143
157MP0003724_increased_susceptibility_to0.42618460
158MP0009053_abnormal_anal_canal0.42408318
159MP0000639_abnormal_adrenal_gland0.42134357
160MP0003953_abnormal_hormone_level0.42130494
161MP0002135_abnormal_kidney_morphology0.41660700
162MP0002928_abnormal_bile_duct0.40898243
163MP0001243_abnormal_dermal_layer0.39982542
164MP0003172_abnormal_lysosome_physiology0.39832116
165MP0000689_abnormal_spleen_morphology0.39529410
166MP0001545_abnormal_hematopoietic_system0.38278309
167MP0005397_hematopoietic_system_phenotyp0.38278309
168MP0005025_abnormal_response_to0.37976269
169MP0000249_abnormal_blood_vessel0.37646734
170MP0001915_intracranial_hemorrhage0.36994081
171MP0001944_abnormal_pancreas_morphology0.36660528
172MP0009384_cardiac_valve_regurgitation0.36309354
173MP0005395_other_phenotype0.36248119
174MP0002254_reproductive_system_inflammat0.36122731
175MP0003075_altered_response_to0.35432795
176MP0010155_abnormal_intestine_physiology0.34168660
177MP0000358_abnormal_cell_content/0.33910371

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.46361373
2Deep venous thrombosis (HP:0002625)6.07118362
3Intrahepatic cholestasis (HP:0001406)5.80820005
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.72872577
5Xanthomatosis (HP:0000991)5.64510727
6Hypobetalipoproteinemia (HP:0003563)5.44322723
7Prolonged partial thromboplastin time (HP:0003645)4.82267234
8Hyperlipoproteinemia (HP:0010980)4.81358520
9Hyperammonemia (HP:0001987)4.63582423
10Ketosis (HP:0001946)4.50518088
11Hyperglycinuria (HP:0003108)4.47675220
12Abnormality of serine family amino acid metabolism (HP:0010894)4.21273252
13Abnormality of glycine metabolism (HP:0010895)4.21273252
14Hyperglycinemia (HP:0002154)4.21174618
15Hypoglycemic coma (HP:0001325)4.20985540
16Complement deficiency (HP:0004431)4.16727365
17Hypolipoproteinemia (HP:0010981)4.07221191
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.95818537
19Abnormality of sulfur amino acid metabolism (HP:0004339)3.87879222
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.76217673
21Abnormality of fatty-acid metabolism (HP:0004359)3.76023079
22Abnormality of aspartate family amino acid metabolism (HP:0010899)3.73267127
23Abnormality of the common coagulation pathway (HP:0010990)3.65202935
24Abnormality of methionine metabolism (HP:0010901)3.58969760
25Joint hemorrhage (HP:0005261)3.58966397
26Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.58496820
27Ketoacidosis (HP:0001993)3.57190017
28Hypoalphalipoproteinemia (HP:0003233)3.52117415
29Fat malabsorption (HP:0002630)3.46761265
30Epidermoid cyst (HP:0200040)3.41041594
31Abnormality of complement system (HP:0005339)3.30863775
32Dicarboxylic aciduria (HP:0003215)3.28610035
33Abnormality of dicarboxylic acid metabolism (HP:0010995)3.28610035
34Abnormality of pyrimidine metabolism (HP:0004353)3.28540297
35Abnormality of the intrinsic pathway (HP:0010989)3.26317761
36Microretrognathia (HP:0000308)3.26100811
37Stridor (HP:0010307)3.25811318
38Hyperbilirubinemia (HP:0002904)3.12290755
39Hypercholesterolemia (HP:0003124)3.07529187
40Abnormality of nucleobase metabolism (HP:0010932)3.03886765
41Microvesicular hepatic steatosis (HP:0001414)3.00996521
42Abnormality of serum amino acid levels (HP:0003112)3.00639161
43Broad distal phalanx of finger (HP:0009836)3.00419415
44Testicular atrophy (HP:0000029)2.98493191
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.93317035
46Increased intramyocellular lipid droplets (HP:0012240)2.91674599
47Abnormality of purine metabolism (HP:0004352)2.91559999
48Progressive muscle weakness (HP:0003323)2.87389764
49Metabolic acidosis (HP:0001942)2.83020093
50Gout (HP:0001997)2.82294302
51Colitis (HP:0002583)2.81344431
52Spastic diplegia (HP:0001264)2.77537424
53Squamous cell carcinoma (HP:0002860)2.76914491
54Abnormal number of erythroid precursors (HP:0012131)2.76138759
55Lethargy (HP:0001254)2.74989183
56Delayed CNS myelination (HP:0002188)2.73659477
57Late onset (HP:0003584)2.69315069
58Generalized aminoaciduria (HP:0002909)2.68544499
59Abnormality of cells of the erythroid lineage (HP:0012130)2.65923301
60Reticulocytopenia (HP:0001896)2.64844225
61Steatorrhea (HP:0002570)2.64323993
62Hepatocellular carcinoma (HP:0001402)2.63767495
63Double outlet right ventricle (HP:0001719)2.60683824
64Congenital malformation of the right heart (HP:0011723)2.60683824
65Pili torti (HP:0003777)2.58609487
66Cerebral edema (HP:0002181)2.57101257
67Myocardial infarction (HP:0001658)2.56439970
68Septate vagina (HP:0001153)2.53122436
69Neoplasm of the adrenal cortex (HP:0100641)2.51654051
70Breast hypoplasia (HP:0003187)2.47945562
71Poikiloderma (HP:0001029)2.45997360
72Aplasia/Hypoplasia of the sacrum (HP:0008517)2.44892066
73Abnormality of the aortic arch (HP:0012303)2.43824630
74Panhypogammaglobulinemia (HP:0003139)2.41430077
75Lipid accumulation in hepatocytes (HP:0006561)2.41222678
76Villous atrophy (HP:0011473)2.38619478
77Abnormality of small intestinal villus morphology (HP:0011472)2.38619478
78Conjugated hyperbilirubinemia (HP:0002908)2.37840574
79Neonatal onset (HP:0003623)2.35880966
80Gastrointestinal inflammation (HP:0004386)2.35735323
81Hypoglycemic seizures (HP:0002173)2.35404226
82Pancreatitis (HP:0001733)2.33238533
83Abnormal cartilage morphology (HP:0002763)2.31643582
84Long foot (HP:0001833)2.30457982
85Seborrheic dermatitis (HP:0001051)2.30064106
86Vomiting (HP:0002013)2.29728742
87Malnutrition (HP:0004395)2.27426991
88Abnormality of iron homeostasis (HP:0011031)2.25824673
89Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.25451306
90Systemic lupus erythematosus (HP:0002725)2.24582389
91Abnormality of transition element cation homeostasis (HP:0011030)2.23928915
92Skin nodule (HP:0200036)2.20157709
93Irritability (HP:0000737)2.19571708
94Increased hepatocellular lipid droplets (HP:0006565)2.18029977
95Acanthocytosis (HP:0001927)2.17501574
96Recurrent bacterial skin infections (HP:0005406)2.17331742
97Increased serum ferritin (HP:0003281)2.16517072
98Rectal prolapse (HP:0002035)2.16506873
99Brushfield spots (HP:0001088)2.15826469
100Acanthosis nigricans (HP:0000956)2.15533806
101Hypokinesia (HP:0002375)2.14529030
102Viral hepatitis (HP:0006562)2.13786721
103Amelogenesis imperfecta (HP:0000705)2.13537282
104Cholecystitis (HP:0001082)2.13277878
105Abnormal gallbladder physiology (HP:0012438)2.13277878
106Cholelithiasis (HP:0001081)2.11162640
107Proximal tubulopathy (HP:0000114)2.11001972
108Myoglobinuria (HP:0002913)2.10947415
109Opisthotonus (HP:0002179)2.10772314
110Respiratory difficulties (HP:0002880)2.09600824
111Hydroxyprolinuria (HP:0003080)2.07521671
112Abnormality of proline metabolism (HP:0010907)2.07521671
113Abnormal hair laboratory examination (HP:0003328)2.07433938
114Recurrent viral infections (HP:0004429)2.06129732
115Abnormal gallbladder morphology (HP:0012437)2.06117565
116Menorrhagia (HP:0000132)2.04747044
117Vascular calcification (HP:0004934)2.04469417
118Inflammation of the large intestine (HP:0002037)2.03572347
119Abnormality of DNA repair (HP:0003254)2.03326943
120Ragged-red muscle fibers (HP:0003200)2.02599738
121Nausea (HP:0002018)2.02558979
122Ureteral duplication (HP:0000073)2.02347126
123Spontaneous abortion (HP:0005268)2.00899274
124Hypertriglyceridemia (HP:0002155)2.00813988
125Growth hormone excess (HP:0000845)2.00468522
126Gingival bleeding (HP:0000225)2.00427410
127Thin bony cortex (HP:0002753)1.98539975
128Sensorimotor neuropathy (HP:0007141)1.98386788
129Hepatic necrosis (HP:0002605)1.97773287
130Absent thumb (HP:0009777)1.96481923
131Rhabdomyolysis (HP:0003201)1.96137475
132Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94788374
133Increased purine levels (HP:0004368)1.94388887
134Hyperuricemia (HP:0002149)1.94388887
135Mitral stenosis (HP:0001718)1.94059619
136Lip pit (HP:0100267)1.93696214
137Hyperacusis (HP:0010780)1.93513580
138Unilateral renal agenesis (HP:0000122)1.91947592
139Thrombophlebitis (HP:0004418)1.91896520
140Increased muscle lipid content (HP:0009058)1.90582503
141Poikilocytosis (HP:0004447)1.90325926
142Reticulocytosis (HP:0001923)1.90316103
143Micronodular cirrhosis (HP:0001413)1.89284202
144Ulnar bowing (HP:0003031)1.88443828
145Progressive external ophthalmoplegia (HP:0000590)1.87946148
146Esophageal varix (HP:0002040)1.87541289
147Glycosuria (HP:0003076)1.87324391
148Abnormality of urine glucose concentration (HP:0011016)1.87324391
149Multiple enchondromatosis (HP:0005701)1.86226173
150Abnormal enzyme/coenzyme activity (HP:0012379)1.85784431
151Duplicated collecting system (HP:0000081)1.84593697
152Cardiovascular calcification (HP:0011915)1.84459622
153Hyperinsulinemic hypoglycemia (HP:0000825)1.84307420
154Renal Fanconi syndrome (HP:0001994)1.83928172
155Elevated hepatic transaminases (HP:0002910)1.83077906
156Tongue fasciculations (HP:0001308)1.82521095
157Recurrent abscess formation (HP:0002722)1.81704804
158Agammaglobulinemia (HP:0004432)1.81562454
159Exercise intolerance (HP:0003546)1.80799094
160Selective tooth agenesis (HP:0001592)1.78842217
161Hypertensive crisis (HP:0100735)1.78394794
162Increased serum lactate (HP:0002151)1.75308214
163Hypergonadotropic hypogonadism (HP:0000815)1.74134046
164Bulbar palsy (HP:0001283)1.73721321
165Abnormality of T cell physiology (HP:0011840)1.73571751
166Birth length less than 3rd percentile (HP:0003561)1.72478595
167Spinal cord compression (HP:0002176)1.72181486
168Enlarged penis (HP:0000040)1.72080699
169Reduced subcutaneous adipose tissue (HP:0003758)1.71257570
17011 pairs of ribs (HP:0000878)1.71104027
171Decreased activity of mitochondrial respiratory chain (HP:0008972)1.71050074
172Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.71050074
173Increased neuronal autofluorescent lipopigment (HP:0002074)1.70541097
174Polygenic inheritance (HP:0010982)1.69900315
175Annular pancreas (HP:0001734)1.69302298
176Aplasia cutis congenita (HP:0001057)1.68194862
177Short thumb (HP:0009778)1.67672849
178Pustule (HP:0200039)1.66150969
179Abdominal distention (HP:0003270)1.64247008
180Hepatocellular necrosis (HP:0001404)1.63184265
181External ophthalmoplegia (HP:0000544)1.63135676
182Basal cell carcinoma (HP:0002671)1.61543366
183Recurrent skin infections (HP:0001581)1.60737128
184Prostate neoplasm (HP:0100787)1.59586833
185Truncus arteriosus (HP:0001660)1.58612822
186Down-sloping shoulders (HP:0200021)1.56837873
187Mitochondrial inheritance (HP:0001427)1.56679331

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.17980870
2SMG15.44943002
3ERN14.65586749
4VRK24.10499681
5TRIB33.95227608
6SIK13.50640231
7PKN23.34322724
8FGFR43.17446239
9TAF12.62292921
10MAP3K102.62235188
11PRKD32.56638311
12EPHA22.49014005
13EEF2K2.35439669
14MAP4K12.34068634
15IRAK32.16954452
16NME22.16767699
17FLT32.12682380
18RIPK11.88803651
19TLK11.87477361
20KDR1.86387111
21MAP3K111.72638895
22TYK21.70066392
23GRK61.64435586
24MAP4K21.64026748
25CDK81.56957082
26STK161.55780558
27MAPK111.55120333
28TESK21.53845138
29MELK1.47623996
30TBK11.46721079
31SCYL21.41285126
32TAOK31.39371409
33PTK61.37824538
34CDK121.37644011
35IRAK21.32278050
36MAP2K31.27549101
37VRK11.24772036
38ZAK1.23484246
39PRPF4B1.22796161
40LRRK21.18148375
41IRAK41.17343104
42TNK21.11222963
43ZAP700.99392310
44NME10.97931748
45ERBB40.96954292
46CDK40.92727807
47CDK90.92392141
48MKNK20.90937949
49CSF1R0.90738497
50PIK3CG0.90222319
51NEK20.89592449
52HIPK20.88985533
53ABL20.88723386
54MAP3K30.88220046
55CDC70.87807959
56RPS6KA40.86659591
57DYRK1B0.86216526
58PRKCI0.85898001
59TGFBR20.85416811
60JAK20.84056122
61PRKD20.82731821
62CHEK20.82054606
63MAPKAPK30.81821396
64MAP3K80.80455746
65PIM20.80257956
66NEK10.79392742
67MST1R0.79112008
68MAPK40.78387821
69ATR0.78207044
70TIE10.78008785
71EPHB10.77987986
72PDK40.77414248
73PDK30.77414248
74RPS6KB20.76638665
75IKBKE0.76441503
76DAPK10.76113459
77INSRR0.74505196
78JAK30.70988283
79CDK60.70575622
80ICK0.70347615
81STK100.68789637
82MTOR0.65877902
83PASK0.65341593
84KIT0.65011576
85BTK0.64400853
86MAPK150.64057806
87DYRK30.64022187
88STK380.63466961
89MAPK120.62561854
90RPS6KC10.62144321
91RPS6KL10.62144321
92NEK90.61169043
93TAOK20.59694304
94MAP2K20.58938722
95PIM10.58928894
96PAK40.58572305
97ILK0.58401416
98IKBKB0.57760583
99ACVR1B0.57260024
100EIF2AK30.54937348
101EIF2AK10.54197979
102CAMK1D0.53854332
103RPS6KA60.53382973
104EIF2AK20.52945478
105BUB10.51422920
106PRKAA20.49804077
107PTK20.49654102
108TGFBR10.49606311
109TESK10.49174139
110JAK10.48756733
111MAP3K70.48436030
112CAMKK10.47104964
113PAK20.46731752
114MAPKAPK20.46451710
115BRSK10.46161126
116TTN0.45912039
117RPS6KA50.45004522
118CSK0.44520843
119PDPK10.44519137
120BMX0.44217390
121BLK0.42957748
122ARAF0.42855329
123RPS6KA20.40903456
124CHEK10.40675576
125WEE10.40361765
126MAP2K60.39159183
127AKT20.37441176
128CDK70.37361635
129NUAK10.37254883
130GSK3A0.36674521
131PRKACG0.36160489
132MUSK0.35810700
133BRAF0.35684165
134AURKB0.34778565
135PINK10.34776509
136PDK10.34535696
137SYK0.33482686
138ERBB20.33120031
139CSNK1G30.32573908
140DAPK30.32456909
141MAP3K10.31626047
142PRKAA10.31064804
143PDGFRA0.30593792
144MAP2K10.29286518
145STK110.28701569
146MAP3K50.27649510
147MAPKAPK50.27019828
148STK40.26080145
149AURKA0.25940051
150CSNK1A1L0.24853109
151GRK50.24432230
152CDC42BPA0.23707915
153SIK30.23334950

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.93176232
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.14985313
3Base excision repair_Homo sapiens_hsa034102.93728415
4Nitrogen metabolism_Homo sapiens_hsa009102.88232468
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.87798439
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.85807963
7Fatty acid degradation_Homo sapiens_hsa000712.76212824
8Arginine biosynthesis_Homo sapiens_hsa002202.65401198
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.64851025
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55118412
11Tryptophan metabolism_Homo sapiens_hsa003802.47176648
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.45698424
13Propanoate metabolism_Homo sapiens_hsa006402.24347152
14Complement and coagulation cascades_Homo sapiens_hsa046102.20350970
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20114817
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.18042650
17Homologous recombination_Homo sapiens_hsa034402.08211309
18Peroxisome_Homo sapiens_hsa041462.08018901
19Butanoate metabolism_Homo sapiens_hsa006502.04479568
20Fatty acid metabolism_Homo sapiens_hsa012122.02096730
21PPAR signaling pathway_Homo sapiens_hsa033201.93451815
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.88387220
23Selenocompound metabolism_Homo sapiens_hsa004501.85843720
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.75381145
25beta-Alanine metabolism_Homo sapiens_hsa004101.72746732
26Folate biosynthesis_Homo sapiens_hsa007901.71087812
27Caffeine metabolism_Homo sapiens_hsa002321.69741346
28Mismatch repair_Homo sapiens_hsa034301.69523146
29Pyruvate metabolism_Homo sapiens_hsa006201.63834784
30Chemical carcinogenesis_Homo sapiens_hsa052041.63551433
31Biosynthesis of amino acids_Homo sapiens_hsa012301.62335068
32Fanconi anemia pathway_Homo sapiens_hsa034601.62324217
33Notch signaling pathway_Homo sapiens_hsa043301.62068464
34Carbon metabolism_Homo sapiens_hsa012001.61305972
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.60977591
36Sulfur relay system_Homo sapiens_hsa041221.60749167
37Histidine metabolism_Homo sapiens_hsa003401.59051548
38RNA polymerase_Homo sapiens_hsa030201.56271924
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.51780587
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50897765
41Primary immunodeficiency_Homo sapiens_hsa053401.49212860
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.49065546
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.42795238
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42475294
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42143365
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.41238248
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39253841
48Nucleotide excision repair_Homo sapiens_hsa034201.37827666
49Non-small cell lung cancer_Homo sapiens_hsa052231.37238728
50Non-homologous end-joining_Homo sapiens_hsa034501.36763830
51Staphylococcus aureus infection_Homo sapiens_hsa051501.36280291
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34236899
53Fat digestion and absorption_Homo sapiens_hsa049751.33398691
54Fatty acid elongation_Homo sapiens_hsa000621.30801889
55Phenylalanine metabolism_Homo sapiens_hsa003601.30068394
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28148702
57Retinol metabolism_Homo sapiens_hsa008301.26818204
58Bile secretion_Homo sapiens_hsa049761.26253434
59One carbon pool by folate_Homo sapiens_hsa006701.24894234
60Sulfur metabolism_Homo sapiens_hsa009201.20939944
61Starch and sucrose metabolism_Homo sapiens_hsa005001.17860596
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17212369
63Cell cycle_Homo sapiens_hsa041101.15501907
64B cell receptor signaling pathway_Homo sapiens_hsa046621.15322724
65Arginine and proline metabolism_Homo sapiens_hsa003301.13264095
66Tyrosine metabolism_Homo sapiens_hsa003501.11921741
67p53 signaling pathway_Homo sapiens_hsa041151.09408979
68Pentose phosphate pathway_Homo sapiens_hsa000301.09094105
69mTOR signaling pathway_Homo sapiens_hsa041501.07694813
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07353630
71Maturity onset diabetes of the young_Homo sapiens_hsa049501.07290980
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01921978
73Chronic myeloid leukemia_Homo sapiens_hsa052200.98890493
74ABC transporters_Homo sapiens_hsa020100.97816173
75Vitamin B6 metabolism_Homo sapiens_hsa007500.97810534
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94806019
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94375131
78Lysine degradation_Homo sapiens_hsa003100.94125994
79Viral carcinogenesis_Homo sapiens_hsa052030.91617749
80Inositol phosphate metabolism_Homo sapiens_hsa005620.91230206
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90191982
82Sphingolipid metabolism_Homo sapiens_hsa006000.88099324
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87732103
84Glutathione metabolism_Homo sapiens_hsa004800.87420495
85Steroid biosynthesis_Homo sapiens_hsa001000.84806509
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84686716
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84253386
88HTLV-I infection_Homo sapiens_hsa051660.84169077
89Vitamin digestion and absorption_Homo sapiens_hsa049770.81934052
90Purine metabolism_Homo sapiens_hsa002300.81755247
91Thyroid cancer_Homo sapiens_hsa052160.79890498
92Alcoholism_Homo sapiens_hsa050340.79371538
93Glycerolipid metabolism_Homo sapiens_hsa005610.78720489
94Pancreatic cancer_Homo sapiens_hsa052120.78412155
95Small cell lung cancer_Homo sapiens_hsa052220.76430438
96Herpes simplex infection_Homo sapiens_hsa051680.76352235
97RNA transport_Homo sapiens_hsa030130.75525725
98Basal cell carcinoma_Homo sapiens_hsa052170.74635338
99Spliceosome_Homo sapiens_hsa030400.72499239
100Hepatitis C_Homo sapiens_hsa051600.70465420
101Epstein-Barr virus infection_Homo sapiens_hsa051690.69513313
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67867093
103Endometrial cancer_Homo sapiens_hsa052130.67721209
104Fatty acid biosynthesis_Homo sapiens_hsa000610.63475780
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62674585
106VEGF signaling pathway_Homo sapiens_hsa043700.62527097
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62213858
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60364296
109Fructose and mannose metabolism_Homo sapiens_hsa000510.57053319
110Metabolic pathways_Homo sapiens_hsa011000.55860247
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53849766
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53670213
113Galactose metabolism_Homo sapiens_hsa000520.50687931
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47858659
115Colorectal cancer_Homo sapiens_hsa052100.46075596
116Apoptosis_Homo sapiens_hsa042100.44998093
117mRNA surveillance pathway_Homo sapiens_hsa030150.44375905
118Prostate cancer_Homo sapiens_hsa052150.44127902
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43195979
120Lysosome_Homo sapiens_hsa041420.40757095
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39141032
122Insulin resistance_Homo sapiens_hsa049310.35185663
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.31051089
124Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28187928
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20494050
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20376984
127AMPK signaling pathway_Homo sapiens_hsa041520.17767511
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17671390
129Prion diseases_Homo sapiens_hsa050200.16841379
130Pyrimidine metabolism_Homo sapiens_hsa002400.15880181
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.14993173
132Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13160273
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12264516
134Glucagon signaling pathway_Homo sapiens_hsa049220.09804927
135Ribosome_Homo sapiens_hsa030100.06241233
136Systemic lupus erythematosus_Homo sapiens_hsa053220.05660822
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.04734751
138DNA replication_Homo sapiens_hsa030300.04177574
139Renin-angiotensin system_Homo sapiens_hsa046140.03536639
140Linoleic acid metabolism_Homo sapiens_hsa005910.03418003
141Glycosaminoglycan degradation_Homo sapiens_hsa005310.03251397
142Insulin signaling pathway_Homo sapiens_hsa049100.02847780
143N-Glycan biosynthesis_Homo sapiens_hsa005100.01121868
144Other glycan degradation_Homo sapiens_hsa005110.00382286
145Proteasome_Homo sapiens_hsa03050-0.1251681
146Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1100802
147Legionellosis_Homo sapiens_hsa05134-0.0979522
148Protein digestion and absorption_Homo sapiens_hsa04974-0.0921424
149Acute myeloid leukemia_Homo sapiens_hsa05221-0.0848222
150Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0706965
151Bladder cancer_Homo sapiens_hsa05219-0.0017442

Most similar genes based on co-expression Upload to Enrichr

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