TYW1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Wybutosine (yW) is a hypermodified guanosine found in phenylalanine tRNA adjacent to the anticodon that stabilizes codon-anticodon interactions in the ribosome. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.91584244
2DNA replication initiation (GO:0006270)4.68277718
3DNA strand elongation (GO:0022616)4.68242677
4telomere maintenance via semi-conservative replication (GO:0032201)4.59953561
5DNA unwinding involved in DNA replication (GO:0006268)4.57080119
6DNA deamination (GO:0045006)4.43231076
7rRNA methylation (GO:0031167)4.38034248
8folic acid-containing compound biosynthetic process (GO:0009396)4.30268393
9transcription from mitochondrial promoter (GO:0006390)4.26332753
10telomere maintenance via recombination (GO:0000722)4.21097143
11nucleobase biosynthetic process (GO:0046112)4.14175830
12protein localization to kinetochore (GO:0034501)4.08182549
13mitotic recombination (GO:0006312)3.98119726
14DNA replication checkpoint (GO:0000076)3.91948046
15purine nucleobase biosynthetic process (GO:0009113)3.90357983
16protein localization to chromosome, centromeric region (GO:0071459)3.85827020
17regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.84299282
18protein deneddylation (GO:0000338)3.80516648
19mitotic metaphase plate congression (GO:0007080)3.80177841
20telomere maintenance via telomere lengthening (GO:0010833)3.75251218
21cullin deneddylation (GO:0010388)3.72104202
22somatic hypermutation of immunoglobulin genes (GO:0016446)3.68796119
23somatic diversification of immune receptors via somatic mutation (GO:0002566)3.68796119
24maturation of SSU-rRNA (GO:0030490)3.67782018
25mitotic nuclear envelope disassembly (GO:0007077)3.64070984
26IMP biosynthetic process (GO:0006188)3.62687227
27RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.61223197
28mitochondrial RNA metabolic process (GO:0000959)3.59533577
29nucleotide-excision repair, DNA gap filling (GO:0006297)3.55057701
30CENP-A containing nucleosome assembly (GO:0034080)3.47781286
31attachment of spindle microtubules to kinetochore (GO:0008608)3.46291421
32chromatin remodeling at centromere (GO:0031055)3.45449960
33pseudouridine synthesis (GO:0001522)3.44631789
34metaphase plate congression (GO:0051310)3.42960905
35nuclear pore organization (GO:0006999)3.42506409
36DNA replication-dependent nucleosome assembly (GO:0006335)3.40726407
37DNA replication-dependent nucleosome organization (GO:0034723)3.40726407
38replication fork processing (GO:0031297)3.39962664
39IMP metabolic process (GO:0046040)3.33094629
40regulation of mitotic spindle checkpoint (GO:1903504)3.32618578
41regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.32618578
42membrane disassembly (GO:0030397)3.31451039
43nuclear envelope disassembly (GO:0051081)3.31451039
44positive regulation of histone H3-K4 methylation (GO:0051571)3.31324247
45ribosomal small subunit assembly (GO:0000028)3.28180718
46folic acid metabolic process (GO:0046655)3.28040683
47pore complex assembly (GO:0046931)3.27468360
48formation of translation preinitiation complex (GO:0001731)3.27048724
49negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.25521022
50protein K6-linked ubiquitination (GO:0085020)3.24711371
51exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.24319014
52ribosome biogenesis (GO:0042254)3.23021739
53ribosome assembly (GO:0042255)3.22409293
54positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.21487662
55mismatch repair (GO:0006298)3.19189158
56nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.17877130
57rRNA catabolic process (GO:0016075)3.17676965
58nuclear pore complex assembly (GO:0051292)3.17482104
59regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.15513664
60tRNA aminoacylation for protein translation (GO:0006418)3.14162242
61mitochondrial DNA replication (GO:0006264)3.13750212
62mitotic sister chromatid cohesion (GO:0007064)3.13262868
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.12277844
64proteasome assembly (GO:0043248)3.12087574
65DNA replication-independent nucleosome assembly (GO:0006336)3.11757838
66DNA replication-independent nucleosome organization (GO:0034724)3.11757838
67transcription elongation from RNA polymerase I promoter (GO:0006362)3.11324677
68DNA duplex unwinding (GO:0032508)3.10381328
69establishment of chromosome localization (GO:0051303)3.08852195
70DNA geometric change (GO:0032392)3.07992445
71regulation of meiosis I (GO:0060631)3.07748323
72peptidyl-histidine modification (GO:0018202)3.06671318
73telomere maintenance (GO:0000723)3.06279963
74double-strand break repair via nonhomologous end joining (GO:0006303)3.05505402
75non-recombinational repair (GO:0000726)3.05505402
76tRNA aminoacylation (GO:0043039)3.05330439
77amino acid activation (GO:0043038)3.05330439
78telomere organization (GO:0032200)3.05314866
79pteridine-containing compound biosynthetic process (GO:0042559)3.01083309
80signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.98280678
81signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.98280678
82signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.98280678
83mitotic chromosome condensation (GO:0007076)2.96427880
84regulation of spindle organization (GO:0090224)2.95922924
85termination of RNA polymerase I transcription (GO:0006363)2.95560542
86DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.95368637
87signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.95340898
88intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.95340898
89ubiquinone biosynthetic process (GO:0006744)2.94249213
90ribonucleoprotein complex biogenesis (GO:0022613)2.93954435
91negative regulation of ligase activity (GO:0051352)2.93916765
92negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.93916765
93L-serine metabolic process (GO:0006563)2.92554909
94translesion synthesis (GO:0019985)2.92361906
95mitotic sister chromatid segregation (GO:0000070)2.92332342
96transcription elongation from RNA polymerase III promoter (GO:0006385)2.91403216
97termination of RNA polymerase III transcription (GO:0006386)2.91403216
98transcription-coupled nucleotide-excision repair (GO:0006283)2.91402624
99signal transduction involved in DNA integrity checkpoint (GO:0072401)2.90666490
100signal transduction involved in DNA damage checkpoint (GO:0072422)2.90666490
101histone mRNA metabolic process (GO:0008334)2.90645293
102histone H2A acetylation (GO:0043968)2.90094863
103signal transduction involved in cell cycle checkpoint (GO:0072395)2.90034475
104base-excision repair, AP site formation (GO:0006285)2.88197499
105regulation of DNA endoreduplication (GO:0032875)2.87994555
106postreplication repair (GO:0006301)2.87300289
107establishment of viral latency (GO:0019043)2.85727903
108tetrahydrofolate metabolic process (GO:0046653)2.84899455
109regulation of cellular amino acid metabolic process (GO:0006521)2.84366100
110somatic recombination of immunoglobulin gene segments (GO:0016447)2.84159902
111histone exchange (GO:0043486)2.81664348
112pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.81643013
113transcription initiation from RNA polymerase I promoter (GO:0006361)2.81183589
114DNA catabolic process, exonucleolytic (GO:0000738)2.80457549
115somatic cell DNA recombination (GO:0016444)2.80133903
116somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.80133903
117ribosomal large subunit biogenesis (GO:0042273)2.79619106
118serine family amino acid biosynthetic process (GO:0009070)2.79328593
119rRNA processing (GO:0006364)2.78779210
120double-strand break repair via homologous recombination (GO:0000724)2.78116214
121positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.77585861
122* tRNA metabolic process (GO:0006399)2.77445485
123somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.77246969
124isotype switching (GO:0045190)2.77246969
125somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.77246969
126kinetochore organization (GO:0051383)2.76155798
127tRNA methylation (GO:0030488)2.75243082
128transcription from RNA polymerase I promoter (GO:0006360)2.74129254
129recombinational repair (GO:0000725)2.73490738
130positive regulation of chromosome segregation (GO:0051984)2.72383312
131* ncRNA processing (GO:0034470)2.72182063
132rRNA metabolic process (GO:0016072)2.72160503
133protein localization to chromosome (GO:0034502)2.72032744
134* ncRNA metabolic process (GO:0034660)2.71549289
135rRNA modification (GO:0000154)2.71485432
136respiratory chain complex IV assembly (GO:0008535)2.71140902
137DNA replication (GO:0006260)2.68436687
138base-excision repair (GO:0006284)2.67940120
139* tRNA processing (GO:0008033)2.67581916
140G1/S transition of mitotic cell cycle (GO:0000082)2.66419269
141cell cycle G1/S phase transition (GO:0044843)2.66419269
142regulation of helicase activity (GO:0051095)2.65669499
143viral transcription (GO:0019083)2.65314022
144regulation of nuclear cell cycle DNA replication (GO:0033262)2.65121231
145translational termination (GO:0006415)2.62670871
146translational elongation (GO:0006414)2.62096491
147pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.61996850
148maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.61761253
149establishment of integrated proviral latency (GO:0075713)2.61387566
150maturation of 5.8S rRNA (GO:0000460)2.60783508
151ribosomal small subunit biogenesis (GO:0042274)2.60673765
152meiotic chromosome segregation (GO:0045132)2.60441231
153negative regulation of chromosome segregation (GO:0051985)2.60016462
154kinetochore assembly (GO:0051382)2.59792237
155negative regulation of mitotic sister chromatid separation (GO:2000816)2.59168674
156negative regulation of mitotic sister chromatid segregation (GO:0033048)2.59168674
157negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.59168674
158negative regulation of sister chromatid segregation (GO:0033046)2.59168674
159glycine metabolic process (GO:0006544)2.58362710
160regulation of centriole replication (GO:0046599)2.57037219
161regulation of double-strand break repair via homologous recombination (GO:0010569)2.57030223
162negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.56743815
163nuclear envelope organization (GO:0006998)2.56233649
164regulation of mitotic metaphase/anaphase transition (GO:0030071)2.56111356

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.97141620
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.84203128
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.50985379
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.43323274
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.38829613
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.97923961
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.72397111
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.65488985
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64262501
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58200237
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.53355678
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.51320967
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50337454
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.42560907
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28371136
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25086287
17AR_21909140_ChIP-Seq_LNCAP_Human2.18260582
18* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17287707
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.11334082
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10901806
21VDR_23849224_ChIP-Seq_CD4+_Human2.05746583
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.00482729
23XRN2_22483619_ChIP-Seq_HELA_Human1.98616753
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.97670973
25* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96018814
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95407544
27* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94773298
28FOXP3_21729870_ChIP-Seq_TREG_Human1.92494083
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.79775806
30GABP_19822575_ChIP-Seq_HepG2_Human1.79335351
31MYC_22102868_ChIP-Seq_BL_Human1.79259231
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78448639
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73805570
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.73047626
35DCP1A_22483619_ChIP-Seq_HELA_Human1.72440058
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70280166
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69458189
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65867063
39CIITA_25753668_ChIP-Seq_RAJI_Human1.63212642
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59770106
41* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59422392
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54436212
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53520089
44* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52335725
45* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50724781
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.50531572
47TTF2_22483619_ChIP-Seq_HELA_Human1.50364876
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50123833
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47401453
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.45911673
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.45697203
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45659567
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44948503
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43717520
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.43668988
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42430375
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.39460907
58EWS_26573619_Chip-Seq_HEK293_Human1.39316656
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38043486
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37964034
61IGF1R_20145208_ChIP-Seq_DFB_Human1.34069109
62* KDM5A_27292631_Chip-Seq_BREAST_Human1.33906721
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33792706
64* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33372549
65* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30198425
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28900709
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.27744912
68ELK1_19687146_ChIP-ChIP_HELA_Human1.26937732
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26177056
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24647342
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23784973
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22357942
73ZNF274_21170338_ChIP-Seq_K562_Hela1.21424865
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19276519
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17555032
76SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17536058
77VDR_22108803_ChIP-Seq_LS180_Human1.17257074
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16618921
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16280373
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15757341
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15297010
82TFEB_21752829_ChIP-Seq_HELA_Human1.13591324
83FUS_26573619_Chip-Seq_HEK293_Human1.12351512
84SPI1_23547873_ChIP-Seq_NB4_Human1.09194603
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09065500
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08485947
87PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08025283
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07945748
89MYC_18940864_ChIP-ChIP_HL60_Human1.07773562
90ELK1_22589737_ChIP-Seq_MCF10A_Human1.07301877
91* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04484848
92EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03486586
93FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03213565
94VDR_21846776_ChIP-Seq_THP-1_Human1.02144918
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01201152
96PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01121247
97POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00517059
98ELF5_23300383_ChIP-Seq_T47D_Human0.97153827
99RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93673626
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92516957
101ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.89720878
102CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89621123
103MYB_26560356_Chip-Seq_TH1_Human0.89230940
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.89230093
105* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88113983
106SALL4_22934838_ChIP-ChIP_CD34+_Human0.87201856
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86584354
108* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85969523
109ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85500589
110RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83214192
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83102035
112MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.82869532
113STAT4_19710469_ChIP-ChIP_TH1__Mouse0.81396921
114SOX17_20123909_ChIP-Seq_XEN_Mouse0.80164045
115UTX_26944678_Chip-Seq_JUKART_Human0.79522183
116MYB_21317192_ChIP-Seq_ERMYB_Mouse0.79500130
117SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79444307
118MAF_26560356_Chip-Seq_TH1_Human0.78360152
119KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.77970798
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.77558558
121SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.75913955
122ER_23166858_ChIP-Seq_MCF-7_Human0.75751828
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.73304794
124CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72206746
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.71992358
126IRF1_19129219_ChIP-ChIP_H3396_Human0.70617170
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.69728058
128CBP_20019798_ChIP-Seq_JUKART_Human0.69728058
129FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69642884

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.94832381
2MP0010094_abnormal_chromosome_stability4.42834687
3MP0003111_abnormal_nucleus_morphology4.12671128
4MP0004957_abnormal_blastocyst_morpholog3.66242060
5MP0003077_abnormal_cell_cycle3.52091000
6MP0008058_abnormal_DNA_repair3.06067022
7MP0009697_abnormal_copulation3.02304497
8MP0008057_abnormal_DNA_replication2.80222586
9MP0002396_abnormal_hematopoietic_system2.61733061
10MP0003806_abnormal_nucleotide_metabolis2.51616774
11MP0003763_abnormal_thymus_physiology2.36747477
12MP0008007_abnormal_cellular_replicative2.32695683
13MP0008877_abnormal_DNA_methylation2.18646557
14MP0003718_maternal_effect2.07384533
15MP0008932_abnormal_embryonic_tissue1.98257048
16MP0006036_abnormal_mitochondrial_physio1.93774709
17MP0010307_abnormal_tumor_latency1.88215278
18MP0001730_embryonic_growth_arrest1.83086597
19MP0008995_early_reproductive_senescence1.82100812
20MP0002009_preneoplasia1.81539208
21MP0006035_abnormal_mitochondrial_morpho1.81472757
22MP0003786_premature_aging1.71535268
23MP0002019_abnormal_tumor_incidence1.69261742
24MP0010352_gastrointestinal_tract_polyps1.68476015
25MP0009840_abnormal_foam_cell1.67889836
26MP0005671_abnormal_response_to1.67491060
27MP0000350_abnormal_cell_proliferation1.63212586
28MP0000372_irregular_coat_pigmentation1.59711794
29MP0006072_abnormal_retinal_apoptosis1.56001870
30MP0000490_abnormal_crypts_of1.55004821
31MP0002132_abnormal_respiratory_system1.49592482
32MP0000689_abnormal_spleen_morphology1.49350420
33MP0002398_abnormal_bone_marrow1.47830376
34MP0003941_abnormal_skin_development1.44454529
35MP0002722_abnormal_immune_system1.43580060
36MP0000703_abnormal_thymus_morphology1.39531705
37MP0003186_abnormal_redox_activity1.37592914
38MP0003950_abnormal_plasma_membrane1.33930853
39MP0009333_abnormal_splenocyte_physiolog1.33284542
40MP0002139_abnormal_hepatobiliary_system1.32736463
41MP0000685_abnormal_immune_system1.31946742
42MP0004808_abnormal_hematopoietic_stem1.31188410
43MP0000313_abnormal_cell_death1.30488217
44MP0000858_altered_metastatic_potential1.28383141
45MP0001672_abnormal_embryogenesis/_devel1.24907263
46MP0005380_embryogenesis_phenotype1.24907263
47MP0003123_paternal_imprinting1.21348834
48MP0002080_prenatal_lethality1.21159302
49MP0000383_abnormal_hair_follicle1.19450822
50MP0003195_calcinosis1.19279548
51MP0001800_abnormal_humoral_immune1.17997274
52MP0001697_abnormal_embryo_size1.16406107
53MP0002429_abnormal_blood_cell1.15209177
54MP0000716_abnormal_immune_system1.12385428
55MP0006292_abnormal_olfactory_placode1.11704712
56MP0001661_extended_life_span1.09907455
57MP0001119_abnormal_female_reproductive1.09698086
58MP0005075_abnormal_melanosome_morpholog1.09595864
59MP0005360_urolithiasis1.07855554
60MP0003984_embryonic_growth_retardation1.06261926
61MP0000427_abnormal_hair_cycle1.06058726
62MP0002210_abnormal_sex_determination1.05782045
63MP0000647_abnormal_sebaceous_gland1.05403000
64MP0009785_altered_susceptibility_to1.03764445
65MP0002088_abnormal_embryonic_growth/wei1.02501367
66MP0002098_abnormal_vibrissa_morphology1.02415282
67MP0002160_abnormal_reproductive_system1.02006808
68MP0002085_abnormal_embryonic_tissue1.01909966
69MP0002405_respiratory_system_inflammati0.99511112
70MP0005408_hypopigmentation0.98967961
71MP0002420_abnormal_adaptive_immunity0.98507852
72MP0001545_abnormal_hematopoietic_system0.97792154
73MP0005397_hematopoietic_system_phenotyp0.97792154
74MP0002723_abnormal_immune_serum0.97597254
75MP0001819_abnormal_immune_cell0.97462294
76MP0004264_abnormal_extraembryonic_tissu0.97262113
77MP0002086_abnormal_extraembryonic_tissu0.96117895
78MP0003943_abnormal_hepatobiliary_system0.95319944
79MP0005395_other_phenotype0.94626010
80MP0002452_abnormal_antigen_presenting0.93103714
81MP0001853_heart_inflammation0.92235506
82MP0004134_abnormal_chest_morphology0.91847056
83MP0001835_abnormal_antigen_presentation0.91793678
84MP0001919_abnormal_reproductive_system0.91658996
85MP0005451_abnormal_body_composition0.91528403
86MP0010678_abnormal_skin_adnexa0.91120186
87MP0005410_abnormal_fertilization0.90132978
88MP0000465_gastrointestinal_hemorrhage0.89979228
89MP0002166_altered_tumor_susceptibility0.89690183
90MP0000653_abnormal_sex_gland0.89110373
91MP0005025_abnormal_response_to0.88933841
92MP0002877_abnormal_melanocyte_morpholog0.88308999
93MP0001145_abnormal_male_reproductive0.87952671
94MP0005253_abnormal_eye_physiology0.87546475
95MP0001929_abnormal_gametogenesis0.86960510
96MP0001764_abnormal_homeostasis0.86639125
97MP0005023_abnormal_wound_healing0.86394250
98MP0002084_abnormal_developmental_patter0.85237946
99MP0005389_reproductive_system_phenotype0.84452580
100MP0000377_abnormal_hair_follicle0.83930158
101MP0005365_abnormal_bile_salt0.83393032
102MP0003699_abnormal_female_reproductive0.82271704
103MP0000477_abnormal_intestine_morphology0.82056913
104MP0003705_abnormal_hypodermis_morpholog0.81898331
105MP0003121_genomic_imprinting0.81266225
106MP0004197_abnormal_fetal_growth/weight/0.79807903
107MP0005384_cellular_phenotype0.79647593
108MP0000598_abnormal_liver_morphology0.79193567
109MP0003656_abnormal_erythrocyte_physiolo0.78080901
110MP0000627_abnormal_mammary_gland0.77723204
111MP0002006_tumorigenesis0.77629378
112MP0003890_abnormal_embryonic-extraembry0.76241576
113MP0005387_immune_system_phenotype0.76146621
114MP0001790_abnormal_immune_system0.76146621
115MP0002095_abnormal_skin_pigmentation0.75709814
116MP0005085_abnormal_gallbladder_physiolo0.75624872
117MP0003698_abnormal_male_reproductive0.74953736
118MP0002876_abnormal_thyroid_physiology0.74852106
119MP0010155_abnormal_intestine_physiology0.74815528
120MP0001915_intracranial_hemorrhage0.74636767
121MP0005319_abnormal_enzyme/_coenzyme0.74331178
122MP0006054_spinal_hemorrhage0.74320832
123MP0003936_abnormal_reproductive_system0.73285551
124MP0003315_abnormal_perineum_morphology0.73173919
125MP0000358_abnormal_cell_content/0.73171844
126MP0003191_abnormal_cellular_cholesterol0.73072030
127MP0005266_abnormal_metabolism0.72512710
128MP0000015_abnormal_ear_pigmentation0.71850285
129MP0009763_increased_sensitivity_to0.70509957
130MP0003448_altered_tumor_morphology0.70364122
131MP0001216_abnormal_epidermal_layer0.69316562
132MP0002638_abnormal_pupillary_reflex0.67626530
133MP0001727_abnormal_embryo_implantation0.67202523
134MP0008875_abnormal_xenobiotic_pharmacok0.66878889
135MP0001984_abnormal_olfaction0.62744822
136MP0008873_increased_physiological_sensi0.62084841
137MP0005501_abnormal_skin_physiology0.60506852
138MP0001881_abnormal_mammary_gland0.60141457
139MP0008789_abnormal_olfactory_epithelium0.59316826
140MP0001191_abnormal_skin_condition0.57871627
141MP0003937_abnormal_limbs/digits/tail_de0.57864912
142MP0005621_abnormal_cell_physiology0.56461258

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.36222735
2Chromsome breakage (HP:0040012)3.49715340
3Reticulocytopenia (HP:0001896)3.33475380
4Impulsivity (HP:0100710)3.25731997
5Increased CSF lactate (HP:0002490)3.24016995
6Breast hypoplasia (HP:0003187)3.21558497
7Agnosia (HP:0010524)3.19902694
8Combined immunodeficiency (HP:0005387)3.19230520
9Oral leukoplakia (HP:0002745)3.17149823
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.16545434
11Renal cortical cysts (HP:0000803)3.15424168
12Abnormality of chromosome stability (HP:0003220)3.06661562
13IgM deficiency (HP:0002850)3.06489815
14Volvulus (HP:0002580)3.03116954
15Increased serum lactate (HP:0002151)2.99701396
16Medulloblastoma (HP:0002885)2.98121917
17Patellar aplasia (HP:0006443)2.96024723
18Abnormality of the renal cortex (HP:0011035)2.94737833
19Acute encephalopathy (HP:0006846)2.93832779
20Severe combined immunodeficiency (HP:0004430)2.93569804
21Acute necrotizing encephalopathy (HP:0006965)2.90795388
22Dyschromatopsia (HP:0007641)2.88973666
23T lymphocytopenia (HP:0005403)2.87895607
24Tubulointerstitial nephritis (HP:0001970)2.86188211
25Abnormality of pyrimidine metabolism (HP:0004353)2.86186259
26Selective tooth agenesis (HP:0001592)2.85523863
27Aplasia/Hypoplasia of the patella (HP:0006498)2.85279507
28Rhabdomyosarcoma (HP:0002859)2.81279331
29Hepatocellular necrosis (HP:0001404)2.73248748
30Ependymoma (HP:0002888)2.70619476
31Abnormality of cells of the erythroid lineage (HP:0012130)2.68544750
32Abnormal mitochondria in muscle tissue (HP:0008316)2.68088526
33Abnormality of T cell number (HP:0011839)2.66227898
34Mitochondrial inheritance (HP:0001427)2.62859466
35Abnormal number of erythroid precursors (HP:0012131)2.60696696
36Hepatic necrosis (HP:0002605)2.60196037
37Dry hair (HP:0011359)2.59483725
38Colon cancer (HP:0003003)2.55932533
39Carpal bone hypoplasia (HP:0001498)2.55712181
40Aplastic anemia (HP:0001915)2.55041944
41Thrombocytosis (HP:0001894)2.51244804
42Abnormality of the preputium (HP:0100587)2.51092673
43Increased hepatocellular lipid droplets (HP:0006565)2.49727500
44Ectopic kidney (HP:0000086)2.48241253
45Generalized aminoaciduria (HP:0002909)2.46058415
46Pancreatic cysts (HP:0001737)2.44747810
47Lymphoma (HP:0002665)2.41390992
48Lipid accumulation in hepatocytes (HP:0006561)2.41359480
49Increased serum pyruvate (HP:0003542)2.41297857
50Meckel diverticulum (HP:0002245)2.40992036
51Progressive macrocephaly (HP:0004481)2.40403846
52Premature graying of hair (HP:0002216)2.39816785
53Microretrognathia (HP:0000308)2.39145195
54Gonadotropin excess (HP:0000837)2.38138711
55Cerebral edema (HP:0002181)2.37336156
56Basal cell carcinoma (HP:0002671)2.35812862
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.33749134
58Abnormality of methionine metabolism (HP:0010901)2.33595289
59Abnormality of T cells (HP:0002843)2.32411141
60Bone marrow hypocellularity (HP:0005528)2.31253304
61Absent thumb (HP:0009777)2.30305746
62Abnormality of glycolysis (HP:0004366)2.30213424
63Glioma (HP:0009733)2.30001318
64Rough bone trabeculation (HP:0100670)2.28462154
65Slender long bone (HP:0003100)2.26668276
66Abnormality of the ileum (HP:0001549)2.26065479
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.24494084
68Abnormal protein N-linked glycosylation (HP:0012347)2.24494084
69Abnormal protein glycosylation (HP:0012346)2.24494084
70Abnormal glycosylation (HP:0012345)2.24494084
71Prostate neoplasm (HP:0100787)2.23165022
72Anhidrosis (HP:0000970)2.22605654
73Recurrent bronchitis (HP:0002837)2.20368543
7411 pairs of ribs (HP:0000878)2.20286809
75Premature ovarian failure (HP:0008209)2.17881305
76Poikiloderma (HP:0001029)2.17475820
77Lactic acidosis (HP:0003128)2.17051360
78Myelodysplasia (HP:0002863)2.16468338
79Abnormality of alanine metabolism (HP:0010916)2.15583492
80Hyperalaninemia (HP:0003348)2.15583492
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15583492
82Hypoplasia of the thymus (HP:0000778)2.15502977
83Bile duct proliferation (HP:0001408)2.15426049
84Abnormal biliary tract physiology (HP:0012439)2.15426049
85Squamous cell carcinoma (HP:0002860)2.14934620
86Degeneration of anterior horn cells (HP:0002398)2.14762016
87Abnormality of the anterior horn cell (HP:0006802)2.14762016
88Abnormality of aspartate family amino acid metabolism (HP:0010899)2.14034192
89Sloping forehead (HP:0000340)2.13316537
90Tubular atrophy (HP:0000092)2.12232191
91Thyroiditis (HP:0100646)2.10183763
92Autoimmune hemolytic anemia (HP:0001890)2.10097130
93Macrocytic anemia (HP:0001972)2.09162680
94Neoplasm of the pancreas (HP:0002894)2.09013892
95Abnormality of the renal medulla (HP:0100957)2.07145506
96Nephronophthisis (HP:0000090)2.04672222
97Limb hypertonia (HP:0002509)2.04010311
98IgG deficiency (HP:0004315)2.03514075
99Hypobetalipoproteinemia (HP:0003563)2.03044179
100Pancreatic islet-cell hyperplasia (HP:0004510)2.02928112
101Renal Fanconi syndrome (HP:0001994)2.02875195
102High pitched voice (HP:0001620)2.02178649
103Megaloblastic anemia (HP:0001889)2.01588466
104Hyperglycinemia (HP:0002154)2.01010822
105Abnormality of serum amino acid levels (HP:0003112)2.00866532
106Pallor (HP:0000980)2.00774918
107Small intestinal stenosis (HP:0012848)2.00660180
108Duodenal stenosis (HP:0100867)2.00660180
109Clubbing of toes (HP:0100760)2.00596647
110Microvesicular hepatic steatosis (HP:0001414)2.00022894
111Abnormality of monocarboxylic acid metabolism (HP:0010996)1.98579075
112Horseshoe kidney (HP:0000085)1.98451880
113Abnormality of DNA repair (HP:0003254)1.98097068
114Aplasia/Hypoplasia of the thymus (HP:0010515)1.97842674
115Secondary amenorrhea (HP:0000869)1.97071037
116Amaurosis fugax (HP:0100576)1.96667749
117CNS demyelination (HP:0007305)1.96248316
118Abnormality of the carotid arteries (HP:0005344)1.93532109
119Abnormality of the pons (HP:0007361)1.93262149
120Astrocytoma (HP:0009592)1.93123233
121Abnormality of the astrocytes (HP:0100707)1.93123233
122Absent radius (HP:0003974)1.92753547
123Reduced antithrombin III activity (HP:0001976)1.91749279
124Cellular immunodeficiency (HP:0005374)1.91628431
125Abnormal lung lobation (HP:0002101)1.91519161
126Lethargy (HP:0001254)1.90882461
127Supernumerary spleens (HP:0009799)1.90266696
128Type I transferrin isoform profile (HP:0003642)1.89326234
129Prominent nose (HP:0000448)1.88922425
130Cerebral hypomyelination (HP:0006808)1.87534375
131B lymphocytopenia (HP:0010976)1.85169332
132Respiratory difficulties (HP:0002880)1.84332651
133Hypokinesia (HP:0002375)1.83925293
134Pancreatic fibrosis (HP:0100732)1.83644764
135Neoplasm of the colon (HP:0100273)1.83592434
136Type 2 muscle fiber atrophy (HP:0003554)1.83485758
137Pulmonary fibrosis (HP:0002206)1.82407245
138Pancytopenia (HP:0001876)1.82404790
139Abnormal number of incisors (HP:0011064)1.82306676
140Decreased activity of mitochondrial respiratory chain (HP:0008972)1.82267309
141Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.82267309
142Hyperglycinuria (HP:0003108)1.81776796
143Muscle fiber atrophy (HP:0100295)1.78838362
144Facial hemangioma (HP:0000329)1.78732786
145Stomach cancer (HP:0012126)1.78165896
146Hypoplastic pelvis (HP:0008839)1.78021530
147Abnormal spermatogenesis (HP:0008669)1.77931497
148Neoplasm of striated muscle (HP:0009728)1.77387479
149Abnormality of B cell number (HP:0010975)1.77287494
150Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76035791
151Entropion (HP:0000621)1.75921602
152Multiple enchondromatosis (HP:0005701)1.74984697
153Biliary tract neoplasm (HP:0100574)1.74814237
154Aplasia involving forearm bones (HP:0009822)1.73998670
155Absent forearm bone (HP:0003953)1.73998670
156Posterior subcapsular cataract (HP:0007787)1.73945236
157Acute myeloid leukemia (HP:0004808)1.73852154
158Abnormality of the duodenum (HP:0002246)1.73698597
159Fair hair (HP:0002286)1.72829588
160Deviation of the thumb (HP:0009603)1.70943655
161Trismus (HP:0000211)1.70386951
162Abnormal trabecular bone morphology (HP:0100671)1.69894019
163Proximal placement of thumb (HP:0009623)1.69696806
164Asplenia (HP:0001746)1.69470156
165Abnormality of T cell physiology (HP:0011840)1.69396683
166Hypergonadotropic hypogonadism (HP:0000815)1.68713004
167Triphalangeal thumb (HP:0001199)1.68344593

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.01515397
2BUB13.49177619
3CDC73.40353002
4WEE13.12059035
5PDK22.85928277
6TTK2.67526462
7EEF2K2.66689360
8NEK22.54930774
9NUAK12.48675791
10VRK22.47360757
11MUSK2.46156165
12NME22.40145188
13PLK42.28993479
14PBK2.26870994
15ACVR1B2.23040020
16TRIM282.15102235
17EIF2AK32.11933568
18RPS6KB22.10725175
19EIF2AK12.04083586
20TLK12.03281615
21EPHA21.96790528
22MAP4K11.94972886
23ATR1.91670742
24PLK11.89603377
25TAOK31.84164356
26RPS6KA41.84026610
27ZAK1.78133079
28VRK11.76486279
29CDK71.71390350
30DYRK31.71134995
31STK101.70659990
32CHEK21.68719866
33CDK41.66038831
34CDK81.61559898
35PASK1.58319029
36BCKDK1.56540693
37BMPR1B1.54561350
38SRPK11.54462508
39AURKB1.54345522
40TESK21.48724439
41TSSK61.43568613
42BRSK21.42571444
43MAP4K21.42329898
44KDR1.39232819
45MST1R1.39100934
46AURKA1.37934342
47AKT31.34253923
48FRK1.33483815
49STK391.33043260
50MAP3K81.32484586
51NME11.28492257
52CDK121.27745441
53TYK21.27290996
54STK161.27279743
55BCR1.23441511
56CLK11.17451184
57PLK31.14780977
58STK38L1.13659888
59FLT31.12126233
60MKNK21.10211135
61MKNK11.09560928
62PKN21.08044204
63STK41.07849234
64PIM11.06609409
65ERBB31.05181220
66CHEK11.05121820
67TGFBR10.98660414
68NEK90.97616321
69IRAK30.94885709
70MAPKAPK30.88198975
71NEK60.87933542
72STK30.84940970
73ATM0.84636519
74BTK0.83525532
75NEK10.82886180
76MAPK110.82585329
77PLK20.81445026
78MAP3K140.81335972
79IKBKE0.79915808
80OXSR10.78769361
81BRD40.78463577
82TNIK0.78439081
83SCYL20.78190547
84BRAF0.78101933
85CDK20.77469292
86LRRK20.77316896
87WNK40.77176360
88TXK0.77032608
89BRSK10.73987984
90EIF2AK20.72882219
91CDK60.72478343
92LATS10.71831235
93JAK30.71381489
94PAK40.71244886
95KIT0.71099702
96ZAP700.71053505
97BLK0.68558019
98MET0.67471135
99MAP3K100.66805337
100SIK30.63551660
101CSNK2A10.62613106
102ERBB40.62105482
103MAP3K120.61095538
104CSNK2A20.60651490
105TEC0.59086645
106GRK60.59002503
107CDK90.58915613
108PIK3CG0.57817765
109ITK0.57071237
110CSNK1G10.55072828
111CDK10.54671319
112RAF10.54618476
113TAF10.54588938
114MELK0.53221097
115CSF1R0.52928225
116PRKCI0.52924948
117CSNK1A1L0.51948702
118FGFR40.51562915
119CHUK0.51433875
120RPS6KB10.49539241
121IKBKB0.48590892
122TBK10.48532661
123MAP2K20.47100277
124INSRR0.46679999
125RPS6KA50.45570786
126PAK10.45459400
127CSNK1G30.42502996
128CCNB10.41398566
129LYN0.41186772
130MAP3K130.39930674
131IRAK40.37798272
132MAP3K110.37362073
133PIM20.36226672
134CDK30.35539399
135NLK0.35449925
136CSNK1E0.35092782
137TRIB30.34862128
138IGF1R0.34133732
139SYK0.33503420
140KSR10.32522156
141ADRBK20.31347996
142MTOR0.31338555
143MAPKAPK20.30454139
144ALK0.29766905
145AKT10.29698004
146CSK0.29590040
147PRKDC0.28176867
148GRK10.27956716

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.77863053
2Mismatch repair_Homo sapiens_hsa034304.11316100
3One carbon pool by folate_Homo sapiens_hsa006703.12313044
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97715877
5Homologous recombination_Homo sapiens_hsa034402.95086616
6Base excision repair_Homo sapiens_hsa034102.87743398
7Nucleotide excision repair_Homo sapiens_hsa034202.75951186
8RNA polymerase_Homo sapiens_hsa030202.53681043
9Spliceosome_Homo sapiens_hsa030402.49932255
10Proteasome_Homo sapiens_hsa030502.47218657
11Cell cycle_Homo sapiens_hsa041102.39052677
12Ribosome_Homo sapiens_hsa030102.37589547
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.29900165
14RNA transport_Homo sapiens_hsa030132.29138977
15Pyrimidine metabolism_Homo sapiens_hsa002402.26389657
16Non-homologous end-joining_Homo sapiens_hsa034502.23448846
17Fanconi anemia pathway_Homo sapiens_hsa034602.11034166
18Propanoate metabolism_Homo sapiens_hsa006402.10153000
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84021619
20Fatty acid elongation_Homo sapiens_hsa000621.78002508
21RNA degradation_Homo sapiens_hsa030181.71009402
22Basal transcription factors_Homo sapiens_hsa030221.68558229
23Folate biosynthesis_Homo sapiens_hsa007901.65538056
24Selenocompound metabolism_Homo sapiens_hsa004501.53764412
25p53 signaling pathway_Homo sapiens_hsa041151.50065110
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42817135
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.41097288
28Oxidative phosphorylation_Homo sapiens_hsa001901.38122035
29Primary immunodeficiency_Homo sapiens_hsa053401.36791867
30Steroid biosynthesis_Homo sapiens_hsa001001.29185370
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.25569001
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17908010
33Sulfur metabolism_Homo sapiens_hsa009201.17235523
34Parkinsons disease_Homo sapiens_hsa050121.17137400
35Systemic lupus erythematosus_Homo sapiens_hsa053221.15684300
36Other glycan degradation_Homo sapiens_hsa005111.15024672
37Antigen processing and presentation_Homo sapiens_hsa046121.13180823
38Pentose phosphate pathway_Homo sapiens_hsa000301.12205972
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10520697
40mRNA surveillance pathway_Homo sapiens_hsa030151.10439353
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08210897
42Purine metabolism_Homo sapiens_hsa002301.06715466
43Biosynthesis of amino acids_Homo sapiens_hsa012301.06001182
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05055466
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03465419
46Sulfur relay system_Homo sapiens_hsa041221.02567295
47Huntingtons disease_Homo sapiens_hsa050161.00057533
48Butanoate metabolism_Homo sapiens_hsa006500.95930968
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.93285237
50Glutathione metabolism_Homo sapiens_hsa004800.93066549
51Herpes simplex infection_Homo sapiens_hsa051680.93049247
52Epstein-Barr virus infection_Homo sapiens_hsa051690.92390379
53Fatty acid metabolism_Homo sapiens_hsa012120.86846587
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84996210
55Viral carcinogenesis_Homo sapiens_hsa052030.84953767
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82850469
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76723885
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75603735
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.71558388
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68771235
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.68001075
62Measles_Homo sapiens_hsa051620.67570919
63HTLV-I infection_Homo sapiens_hsa051660.63946850
64Carbon metabolism_Homo sapiens_hsa012000.62477102
65Vitamin B6 metabolism_Homo sapiens_hsa007500.59909993
66Protein export_Homo sapiens_hsa030600.58700468
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57659461
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56818885
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54012554
70Lysine degradation_Homo sapiens_hsa003100.53635116
71Small cell lung cancer_Homo sapiens_hsa052220.53343236
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53030054
73Regulation of autophagy_Homo sapiens_hsa041400.51278105
74Apoptosis_Homo sapiens_hsa042100.50340261
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49708107
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48964552
77N-Glycan biosynthesis_Homo sapiens_hsa005100.48476606
78Alzheimers disease_Homo sapiens_hsa050100.48353431
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.48331522
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47808361
81Circadian rhythm_Homo sapiens_hsa047100.46085918
82Retinol metabolism_Homo sapiens_hsa008300.44935371
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39604269
84Hematopoietic cell lineage_Homo sapiens_hsa046400.38473591
85Chemical carcinogenesis_Homo sapiens_hsa052040.38318533
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37693241
87Hepatitis B_Homo sapiens_hsa051610.36710628
88Arginine and proline metabolism_Homo sapiens_hsa003300.36578847
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36501417
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36401789
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36334405
92Peroxisome_Homo sapiens_hsa041460.34150694
93Metabolic pathways_Homo sapiens_hsa011000.33209528
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33022948
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31375662
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31360297
97Tryptophan metabolism_Homo sapiens_hsa003800.31182129
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31141167
99MicroRNAs in cancer_Homo sapiens_hsa052060.30562312
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29363238
101beta-Alanine metabolism_Homo sapiens_hsa004100.28930058
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27603985
103Type I diabetes mellitus_Homo sapiens_hsa049400.27443211
104B cell receptor signaling pathway_Homo sapiens_hsa046620.27441993
105Bladder cancer_Homo sapiens_hsa052190.27253840
106Thyroid cancer_Homo sapiens_hsa052160.26778251
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.25946979
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.24959742
109Caffeine metabolism_Homo sapiens_hsa002320.24646322
110Fructose and mannose metabolism_Homo sapiens_hsa000510.24365059
111TGF-beta signaling pathway_Homo sapiens_hsa043500.23638635
112T cell receptor signaling pathway_Homo sapiens_hsa046600.23601567
113Vitamin digestion and absorption_Homo sapiens_hsa049770.23558770
114Autoimmune thyroid disease_Homo sapiens_hsa053200.23217200
115Shigellosis_Homo sapiens_hsa051310.22493918
116Galactose metabolism_Homo sapiens_hsa000520.21978382
117Fatty acid degradation_Homo sapiens_hsa000710.21196766
118Colorectal cancer_Homo sapiens_hsa052100.21161012
119Pyruvate metabolism_Homo sapiens_hsa006200.21051831
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20390360
121Oocyte meiosis_Homo sapiens_hsa041140.20211855
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.19720004
123Pancreatic cancer_Homo sapiens_hsa052120.19692547
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19373244
125Legionellosis_Homo sapiens_hsa051340.18176157
126Nitrogen metabolism_Homo sapiens_hsa009100.14956741
127Allograft rejection_Homo sapiens_hsa053300.12674184

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