TYW1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Wybutosine is a hypermodified guanosine found in phenylalanine tRNA. Wybutosine functions to stabilize codon-anticodon interactions during ribosome decoding and therefore supports the maintenance of the reading frame. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. The human genome contains two closely related genes that putatively function in wybutosine synthesis. The open reading frame of this locus is disrupted in some individuals. Thus, this locus appears to be an evolving pseudogene, but may still be functional in some members of the population. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1rRNA methylation (GO:0031167)4.90031944
2rRNA modification (GO:0000154)4.89741730
3regulation of meiosis I (GO:0060631)4.86986112
4piRNA metabolic process (GO:0034587)4.65226265
5positive regulation of immune response to tumor cell (GO:0002839)4.44083960
6regulation of immune response to tumor cell (GO:0002837)4.44083960
7regulation of response to tumor cell (GO:0002834)4.44083960
8positive regulation of response to tumor cell (GO:0002836)4.44083960
9DNA methylation involved in gamete generation (GO:0043046)4.30843896
10respiratory chain complex IV assembly (GO:0008535)4.19009085
11establishment of protein localization to mitochondrial membrane (GO:0090151)4.09267662
12protein-chromophore linkage (GO:0018298)4.02581854
13meiotic chromosome segregation (GO:0045132)4.02129795
14peptidyl-histidine modification (GO:0018202)3.81724035
15maturation of 5.8S rRNA (GO:0000460)3.81567321
16protein complex biogenesis (GO:0070271)3.68246724
17mitochondrial respiratory chain complex assembly (GO:0033108)3.63899925
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.63364395
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.63364395
20NADH dehydrogenase complex assembly (GO:0010257)3.63364395
21negative regulation of DNA-dependent DNA replication (GO:2000104)3.61029537
22centriole replication (GO:0007099)3.56784695
23cytochrome complex assembly (GO:0017004)3.43202882
24ribonucleoprotein complex disassembly (GO:0032988)3.30026950
25DNA deamination (GO:0045006)3.28133745
26RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.27992626
27tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.27992626
28protein K6-linked ubiquitination (GO:0085020)3.25062399
29regulation of DNA endoreduplication (GO:0032875)3.22729065
30exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.22388338
31water-soluble vitamin biosynthetic process (GO:0042364)3.22257618
32nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20223427
33activated T cell proliferation (GO:0050798)3.19112866
34organelle disassembly (GO:1903008)3.18481666
35protein deneddylation (GO:0000338)3.13780652
36establishment of integrated proviral latency (GO:0075713)3.11818325
37cullin deneddylation (GO:0010388)3.05631250
38chromatin remodeling at centromere (GO:0031055)3.04923761
39negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.03196742
40pseudouridine synthesis (GO:0001522)3.03144444
41sphingosine metabolic process (GO:0006670)3.01497987
42transcription elongation from RNA polymerase III promoter (GO:0006385)2.99474196
43termination of RNA polymerase III transcription (GO:0006386)2.99474196
44chaperone-mediated protein transport (GO:0072321)2.97440745
45mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.94945885
46CENP-A containing nucleosome assembly (GO:0034080)2.93989034
47somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.92803525
48somatic cell DNA recombination (GO:0016444)2.92803525
49V(D)J recombination (GO:0033151)2.92729002
50nuclear pore complex assembly (GO:0051292)2.91371575
51reciprocal DNA recombination (GO:0035825)2.91197125
52reciprocal meiotic recombination (GO:0007131)2.91197125
53male meiosis I (GO:0007141)2.87421551
54regulation of nuclear cell cycle DNA replication (GO:0033262)2.86843408
55histone mRNA metabolic process (GO:0008334)2.84687698
56double-strand break repair via homologous recombination (GO:0000724)2.83725112
57synapsis (GO:0007129)2.83522383
58recombinational repair (GO:0000725)2.81581946
59isotype switching (GO:0045190)2.79987081
60somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.79987081
61somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.79987081
62* tRNA processing (GO:0008033)2.79043742
63somatic diversification of immune receptors (GO:0002200)2.78447064
64nuclear pore organization (GO:0006999)2.77822435
65histone exchange (GO:0043486)2.76450520
66diol metabolic process (GO:0034311)2.75637280
67regulation of female receptivity (GO:0045924)2.75103633
68resolution of meiotic recombination intermediates (GO:0000712)2.74777927
69sphingoid metabolic process (GO:0046519)2.72697770
70mitotic spindle checkpoint (GO:0071174)2.71917741
71replication fork processing (GO:0031297)2.70466881
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.70296004
73acrosome reaction (GO:0007340)2.70002240
74RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.69734450
75neural tube formation (GO:0001841)2.67460719
76epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.67405200
77DNA double-strand break processing (GO:0000729)2.67370911
78spindle checkpoint (GO:0031577)2.67141500
79regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.65980431
80somatic recombination of immunoglobulin gene segments (GO:0016447)2.65143605
81proteasome assembly (GO:0043248)2.64166207
82rRNA processing (GO:0006364)2.61488353
83telomere maintenance via telomerase (GO:0007004)2.58572533
84negative regulation of chromosome segregation (GO:0051985)2.56231958
85positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.56183913
86negative regulation of mitotic sister chromatid separation (GO:2000816)2.55957021
87negative regulation of sister chromatid segregation (GO:0033046)2.55957021
88negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.55957021
89negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.55957021
90negative regulation of mitotic sister chromatid segregation (GO:0033048)2.55957021
91non-recombinational repair (GO:0000726)2.55905069
92double-strand break repair via nonhomologous end joining (GO:0006303)2.55905069
93postreplication repair (GO:0006301)2.54988357
94regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.54773689
95regulation of mitotic spindle checkpoint (GO:1903504)2.54773689
96* ncRNA metabolic process (GO:0034660)2.54235395
97* ncRNA processing (GO:0034470)2.54138119
98rRNA metabolic process (GO:0016072)2.52108732
99meiosis I (GO:0007127)2.51758133
100spliceosomal snRNP assembly (GO:0000387)2.50942086

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.29551594
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.92395184
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.61034261
4IGF1R_20145208_ChIP-Seq_DFB_Human3.23480799
5* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.87544378
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.75463087
7ELK1_19687146_ChIP-ChIP_HELA_Human2.74725522
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.73942313
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.59280101
10VDR_22108803_ChIP-Seq_LS180_Human2.56116033
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.54057446
12ZNF274_21170338_ChIP-Seq_K562_Hela2.49045936
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.41255882
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.39931597
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.37128377
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.35474910
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.34086767
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.34071391
19VDR_23849224_ChIP-Seq_CD4+_Human2.30010843
20FOXP3_21729870_ChIP-Seq_TREG_Human2.09704846
21E2F7_22180533_ChIP-Seq_HELA_Human2.02878576
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00209562
23FUS_26573619_Chip-Seq_HEK293_Human1.97022744
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95954059
25EWS_26573619_Chip-Seq_HEK293_Human1.92139414
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.82630571
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81499750
28MYC_18940864_ChIP-ChIP_HL60_Human1.77532654
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77163578
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72841470
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.71496672
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69929545
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63947856
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.59449128
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56530161
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.55932655
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.53686048
38ER_23166858_ChIP-Seq_MCF-7_Human1.51833777
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48920901
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.47637876
41P300_19829295_ChIP-Seq_ESCs_Human1.47152478
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46089999
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41162973
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37788487
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35150781
46TP53_22573176_ChIP-Seq_HFKS_Human1.33207541
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31332339
48TAF15_26573619_Chip-Seq_HEK293_Human1.29910959
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27713551
50TTF2_22483619_ChIP-Seq_HELA_Human1.26290874
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.26111999
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.25480302
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25002821
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24482719
55* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23493562
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23032555
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21242399
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20707374
59CBP_20019798_ChIP-Seq_JUKART_Human1.20510191
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20510191
61SOX2_19829295_ChIP-Seq_ESCs_Human1.17955241
62NANOG_19829295_ChIP-Seq_ESCs_Human1.17955241
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16333892
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15655197
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15343163
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14767356
67DCP1A_22483619_ChIP-Seq_HELA_Human1.14306147
68GABP_19822575_ChIP-Seq_HepG2_Human1.11777882
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.10102431
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04236816
71HOXB7_26014856_ChIP-Seq_BT474_Human1.04015347
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03208067
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01535018
74HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00468540
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99422549
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98841628
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96940796
78LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96794473
79SALL4_22934838_ChIP-ChIP_CD34+_Human0.96446134
80FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95757110
81AR_21572438_ChIP-Seq_LNCaP_Human0.95624860
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94219508
83AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93806516
84MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92926384
85EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92049015
86CRX_20693478_ChIP-Seq_RETINA_Mouse0.91888869
87STAT3_23295773_ChIP-Seq_U87_Human0.91814005
88TP63_19390658_ChIP-ChIP_HaCaT_Human0.91540329
89AR_25329375_ChIP-Seq_VCAP_Human0.90707157
90FOXA1_25329375_ChIP-Seq_VCAP_Human0.89551917
91FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89551917
92FOXM1_23109430_ChIP-Seq_U2OS_Human0.89494708
93BCAT_22108803_ChIP-Seq_LS180_Human0.89311340
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89165848
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89165848
96NELFA_20434984_ChIP-Seq_ESCs_Mouse0.88676882
97NANOG_18555785_Chip-Seq_ESCs_Mouse0.87773017
98P300_18555785_Chip-Seq_ESCs_Mouse0.86903924
99E2F1_21310950_ChIP-Seq_MCF-7_Human0.86860552
100TCF4_22108803_ChIP-Seq_LS180_Human0.86638243

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color6.61424128
2MP0002163_abnormal_gland_morphology4.21137489
3MP0005171_absent_coat_pigmentation3.48800394
4MP0008057_abnormal_DNA_replication3.48351446
5MP0000569_abnormal_digit_pigmentation3.31423880
6MP0000372_irregular_coat_pigmentation3.19148466
7MP0008877_abnormal_DNA_methylation3.17279382
8MP0005379_endocrine/exocrine_gland_phen2.82322794
9MP0004381_abnormal_hair_follicle2.70395694
10MP0002837_dystrophic_cardiac_calcinosis2.65778422
11MP0008058_abnormal_DNA_repair2.62675615
12MP0002653_abnormal_ependyma_morphology2.39098345
13MP0003693_abnormal_embryo_hatching2.35050912
14MP0003787_abnormal_imprinting2.19566405
15MP0002638_abnormal_pupillary_reflex2.17036935
16MP0010094_abnormal_chromosome_stability2.09084396
17MP0003718_maternal_effect1.93890373
18MP0003890_abnormal_embryonic-extraembry1.88372330
19MP0002938_white_spotting1.86355787
20MP0000015_abnormal_ear_pigmentation1.83594871
21MP0002876_abnormal_thyroid_physiology1.76329683
22MP0005174_abnormal_tail_pigmentation1.76258167
23MP0002095_abnormal_skin_pigmentation1.76076636
24MP0003646_muscle_fatigue1.69358911
25MP0001529_abnormal_vocalization1.66182419
26MP0004957_abnormal_blastocyst_morpholog1.64390022
27MP0005408_hypopigmentation1.62714550
28MP0003195_calcinosis1.59596872
29MP0003077_abnormal_cell_cycle1.53683402
30MP0008007_abnormal_cellular_replicative1.53481635
31MP0002138_abnormal_hepatobiliary_system1.41945591
32MP0006072_abnormal_retinal_apoptosis1.41024698
33MP0003786_premature_aging1.39630386
34MP0002102_abnormal_ear_morphology1.37272527
35MP0003111_abnormal_nucleus_morphology1.30142250
36MP0003121_genomic_imprinting1.25290284
37MP0001929_abnormal_gametogenesis1.24504552
38MP0005671_abnormal_response_to1.24462159
39MP0001986_abnormal_taste_sensitivity1.24095870
40MP0005075_abnormal_melanosome_morpholog1.23092340
41MP0005253_abnormal_eye_physiology1.20887574
42MP0003186_abnormal_redox_activity1.20798961
43MP0002210_abnormal_sex_determination1.19721146
44MP0005084_abnormal_gallbladder_morpholo1.17493913
45MP0001984_abnormal_olfaction1.16750379
46MP0005551_abnormal_eye_electrophysiolog1.14651841
47MP0005410_abnormal_fertilization1.13669236
48MP0008789_abnormal_olfactory_epithelium1.13439962
49MP0008995_early_reproductive_senescence1.03987168
50MP0005310_abnormal_salivary_gland1.02410096
51MP0005395_other_phenotype1.01070653
52MP0006035_abnormal_mitochondrial_morpho0.99518114
53MP0008932_abnormal_embryonic_tissue0.98598021
54MP0001485_abnormal_pinna_reflex0.96182436
55MP0001764_abnormal_homeostasis0.96030539
56MP0002928_abnormal_bile_duct0.94200073
57MP0001324_abnormal_eye_pigmentation0.93392972
58MP0006292_abnormal_olfactory_placode0.92202342
59MP0002132_abnormal_respiratory_system0.91620908
60MP0002277_abnormal_respiratory_mucosa0.91473464
61MP0010307_abnormal_tumor_latency0.89818379
62MP0006276_abnormal_autonomic_nervous0.89773692
63MP0000653_abnormal_sex_gland0.89205478
64MP0005645_abnormal_hypothalamus_physiol0.89175869
65MP0004142_abnormal_muscle_tone0.88680061
66MP0000647_abnormal_sebaceous_gland0.87029187
67MP0003698_abnormal_male_reproductive0.86278425
68MP0000427_abnormal_hair_cycle0.85106364
69MP0003123_paternal_imprinting0.84037464
70MP0001346_abnormal_lacrimal_gland0.83031261
71MP0001293_anophthalmia0.82837749
72MP0001145_abnormal_male_reproductive0.78206448
73MP0006036_abnormal_mitochondrial_physio0.77937929
74MP0009697_abnormal_copulation0.75183533
75MP0002160_abnormal_reproductive_system0.74051767
76MP0009046_muscle_twitch0.73880034
77MP0005187_abnormal_penis_morphology0.73327944
78MP0002166_altered_tumor_susceptibility0.72163777
79MP0003567_abnormal_fetal_cardiomyocyte0.70844466
80MP0001119_abnormal_female_reproductive0.69986712
81MP0001348_abnormal_lacrimal_gland0.68006142
82MP0004147_increased_porphyrin_level0.66301120
83MP0005499_abnormal_olfactory_system0.65805209
84MP0005394_taste/olfaction_phenotype0.65805209
85MP0003045_fibrosis0.65535032
86MP0000685_abnormal_immune_system0.65042915
87MP0003943_abnormal_hepatobiliary_system0.62101888
88MP0002751_abnormal_autonomic_nervous0.62059916
89MP0002006_tumorigenesis0.61403888
90MP0001661_extended_life_span0.61107962
91MP0001186_pigmentation_phenotype0.58351650
92MP0002075_abnormal_coat/hair_pigmentati0.58040830
93MP0001800_abnormal_humoral_immune0.55431714
94MP0002233_abnormal_nose_morphology0.54239478
95MP0000538_abnormal_urinary_bladder0.52958731
96MP0005391_vision/eye_phenotype0.52685380
97MP0004742_abnormal_vestibular_system0.52620814
98MP0002735_abnormal_chemical_nociception0.50852308
99MP0009780_abnormal_chondrocyte_physiolo0.50662607
100MP0000383_abnormal_hair_follicle0.50598590

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)3.57656295
2Pancreatic cysts (HP:0001737)3.44907067
3Acute necrotizing encephalopathy (HP:0006965)3.38345855
4Volvulus (HP:0002580)3.24318220
5Progressive macrocephaly (HP:0004481)3.21999591
6Neoplasm of the adrenal cortex (HP:0100641)3.09855399
7Abnormality of the renal cortex (HP:0011035)3.08458013
8Acute encephalopathy (HP:0006846)3.00478491
9Abnormal mitochondria in muscle tissue (HP:0008316)2.96290761
10Nephronophthisis (HP:0000090)2.94745249
11Mitochondrial inheritance (HP:0001427)2.91798671
12Increased CSF lactate (HP:0002490)2.85528557
13Increased hepatocellular lipid droplets (HP:0006565)2.85299566
14Abnormality of the renal medulla (HP:0100957)2.82237916
15Autoimmune hemolytic anemia (HP:0001890)2.81756938
16Thyroiditis (HP:0100646)2.70368629
17Aplasia/Hypoplasia of the uvula (HP:0010293)2.68958336
18Colon cancer (HP:0003003)2.65157899
19Abnormality of the pons (HP:0007361)2.61012879
20Tubular atrophy (HP:0000092)2.60485543
21Severe visual impairment (HP:0001141)2.57515296
22Cutaneous melanoma (HP:0012056)2.51929401
23Lipid accumulation in hepatocytes (HP:0006561)2.51183501
24Increased serum lactate (HP:0002151)2.44479621
25Progressive inability to walk (HP:0002505)2.42379270
26B lymphocytopenia (HP:0010976)2.40428441
27Hepatocellular necrosis (HP:0001404)2.34553181
28Abnormality of midbrain morphology (HP:0002418)2.33977333
29Molar tooth sign on MRI (HP:0002419)2.33977333
30True hermaphroditism (HP:0010459)2.30974237
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.29023667
32Medial flaring of the eyebrow (HP:0010747)2.28454619
33Chromsome breakage (HP:0040012)2.22950700
34Erythroderma (HP:0001019)2.22668620
35Hypoplasia of the pons (HP:0012110)2.21367950
36Hypothermia (HP:0002045)2.19991808
37Hypoplasia of the fovea (HP:0007750)2.17020577
38Aplasia/Hypoplasia of the fovea (HP:0008060)2.17020577
39Albinism (HP:0001022)2.15354538
40Hypoproteinemia (HP:0003075)2.14644369
41Optic disc pallor (HP:0000543)2.14441324
42Parakeratosis (HP:0001036)2.13633931
43Increased IgM level (HP:0003496)2.12324219
44Hepatic necrosis (HP:0002605)2.11761816
45Pancreatic fibrosis (HP:0100732)2.10564423
46Respiratory difficulties (HP:0002880)2.10172881
47Aplastic anemia (HP:0001915)2.09811639
48Renal Fanconi syndrome (HP:0001994)2.07298155
49Abnormality of chromosome stability (HP:0003220)2.07220051
50Abnormality of B cell number (HP:0010975)2.06449720
51IgG deficiency (HP:0004315)2.05510405
52Severe combined immunodeficiency (HP:0004430)2.03774625
53Leukodystrophy (HP:0002415)2.03174425
54Attenuation of retinal blood vessels (HP:0007843)2.02996980
55Abnormality of the ileum (HP:0001549)2.00109441
56Eosinophilia (HP:0001880)1.99649204
57Pendular nystagmus (HP:0012043)1.99235478
58Abnormality of T cell number (HP:0011839)1.98872336
59Autoimmune thrombocytopenia (HP:0001973)1.98624621
60Neoplasm of the adrenal gland (HP:0100631)1.97258129
61Cerebral edema (HP:0002181)1.96118118
62Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.96086375
63Meckel diverticulum (HP:0002245)1.94370703
64Chronic hepatic failure (HP:0100626)1.94333609
65Respiratory failure (HP:0002878)1.94292313
66Abnormal rod and cone electroretinograms (HP:0008323)1.90510801
67Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.89787980
68Renal cortical cysts (HP:0000803)1.89376055
69Sloping forehead (HP:0000340)1.88653373
70Lactic acidosis (HP:0003128)1.85593485
71Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85119831
72Nephroblastoma (Wilms tumor) (HP:0002667)1.84255966
73Combined immunodeficiency (HP:0005387)1.83970562
74Rhabdomyosarcoma (HP:0002859)1.82534474
75Abnormality of the preputium (HP:0100587)1.81576404
76Amelogenesis imperfecta (HP:0000705)1.81432870
77Abnormality of eosinophils (HP:0001879)1.80668262
78Abnormality of macular pigmentation (HP:0008002)1.80608671
79Carpal bone hypoplasia (HP:0001498)1.80264761
80Constricted visual fields (HP:0001133)1.78758467
8111 pairs of ribs (HP:0000878)1.78485317
82Short chin (HP:0000331)1.78431008
83Enlarged kidneys (HP:0000105)1.75919211
84Embryonal renal neoplasm (HP:0011794)1.75404790
85Abnormality of the fovea (HP:0000493)1.74112955
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.74097500
87Abnormality of alanine metabolism (HP:0010916)1.74097500
88Hyperalaninemia (HP:0003348)1.74097500
89Small hand (HP:0200055)1.73898251
90Absent/shortened dynein arms (HP:0200106)1.73864528
91Dynein arm defect of respiratory motile cilia (HP:0012255)1.73864528
92Abnormal drinking behavior (HP:0030082)1.71215766
93Polydipsia (HP:0001959)1.71215766
94Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.71088447
95Bony spicule pigmentary retinopathy (HP:0007737)1.70051028
96Exertional dyspnea (HP:0002875)1.67585302
97Nephrogenic diabetes insipidus (HP:0009806)1.67516574
98Pancytopenia (HP:0001876)1.65263301
99Large for gestational age (HP:0001520)1.65246949
100Horizontal nystagmus (HP:0000666)1.64908059

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.88506456
2BUB13.43466076
3TSSK63.30145945
4ZAK3.10310523
5EIF2AK33.03967982
6STK38L3.02317874
7LATS12.91070801
8BCR2.58144781
9MST42.39501277
10VRK22.25402172
11NLK2.14263998
12ACVR1B2.03541219
13SRPK12.02940773
14BMPR1B1.92281083
15TAF11.87248220
16NUAK11.80684594
17WNK31.78620093
18EIF2AK11.77790871
19STK31.64805804
20PBK1.59141562
21NME11.55350905
22TNIK1.55155675
23TXK1.54202731
24VRK11.51657298
25FGFR21.49958460
26PLK41.48358551
27MARK31.43154302
28PLK31.42528734
29PNCK1.34113062
30MKNK21.28758667
31TRIM281.27981646
32LATS21.27799528
33MAP4K21.24246179
34PIK3CG1.18933063
35CDC71.17322718
36PDK21.13977146
37AKT31.11685530
38INSRR1.06646661
39PAK31.06517518
40GRK11.04551416
41ADRBK21.03524978
42MUSK1.03422161
43EIF2AK20.98732960
44TGFBR10.98287871
45TTK0.94550147
46TGFBR20.89822001
47WEE10.88857465
48STK390.88443248
49MAP3K90.86698023
50PLK20.83493568
51PINK10.83284386
52PLK10.82268174
53KSR10.78875405
54WNK40.76508536
55ATR0.75807754
56STK160.74615063
57TLK10.73041454
58BRSK20.72822497
59MAP3K20.70651321
60MKNK10.61340999
61CSNK1G10.60746205
62NTRK30.59125739
63PIM10.58892562
64STK240.58027658
65MELK0.56046324
66FER0.56009083
67CSNK1A1L0.54727311
68CHEK10.52432631
69ATM0.51503899
70CASK0.47336427
71PRKD30.47174018
72AURKB0.46259550
73TEC0.45351682
74CDK30.45253952
75CLK10.45217567
76STK40.44460805
77IKBKB0.43753219
78CSNK2A20.42739707
79FGFR10.42049121
80KSR20.40172473
81CSNK2A10.39844650
82FGFR30.39746320
83SGK20.37029229
84RAF10.35780518
85OXSR10.33801480
86RPS6KA40.32259855
87DYRK1A0.32137396
88DYRK20.31536946
89CSNK1A10.31097300
90DYRK30.30308237
91TAOK30.30156317
92PASK0.29942094
93CHEK20.29925255
94KIT0.29835674
95NEK60.29437615
96MAP3K140.28845249
97PAK10.27525483
98BRSK10.26444677
99CSNK1E0.26227265
100PRKCI0.25974904

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.58449868
2Non-homologous end-joining_Homo sapiens_hsa034503.40537675
3Proteasome_Homo sapiens_hsa030503.34907956
4RNA polymerase_Homo sapiens_hsa030202.96827521
5Basal transcription factors_Homo sapiens_hsa030222.80454362
6Homologous recombination_Homo sapiens_hsa034402.64521696
7Mismatch repair_Homo sapiens_hsa034302.63110920
8Oxidative phosphorylation_Homo sapiens_hsa001902.57752720
9Ribosome_Homo sapiens_hsa030102.46462045
10Protein export_Homo sapiens_hsa030602.32453332
11RNA degradation_Homo sapiens_hsa030182.20720255
12Steroid biosynthesis_Homo sapiens_hsa001002.19460711
13Fanconi anemia pathway_Homo sapiens_hsa034602.10411187
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.00668831
15RNA transport_Homo sapiens_hsa030131.98678106
16DNA replication_Homo sapiens_hsa030301.95526803
17Parkinsons disease_Homo sapiens_hsa050121.89360635
18Spliceosome_Homo sapiens_hsa030401.80670376
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.76059538
20One carbon pool by folate_Homo sapiens_hsa006701.72811441
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69984290
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67920242
23Nucleotide excision repair_Homo sapiens_hsa034201.67717692
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64610137
25Propanoate metabolism_Homo sapiens_hsa006401.56333166
26Huntingtons disease_Homo sapiens_hsa050161.56077498
27Butanoate metabolism_Homo sapiens_hsa006501.47458320
28Phototransduction_Homo sapiens_hsa047441.46797290
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43997528
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.40423767
31Cell cycle_Homo sapiens_hsa041101.39252868
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37885217
33Regulation of autophagy_Homo sapiens_hsa041401.36821713
34Selenocompound metabolism_Homo sapiens_hsa004501.35923623
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35057047
36Pyrimidine metabolism_Homo sapiens_hsa002401.32803527
37Fatty acid elongation_Homo sapiens_hsa000621.31929546
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.27710967
39Purine metabolism_Homo sapiens_hsa002301.23280105
40Base excision repair_Homo sapiens_hsa034101.22195983
41Tryptophan metabolism_Homo sapiens_hsa003801.19958030
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10272366
43Alzheimers disease_Homo sapiens_hsa050101.08994769
44Oocyte meiosis_Homo sapiens_hsa041141.08588242
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99659464
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92819955
47Collecting duct acid secretion_Homo sapiens_hsa049660.88748683
48p53 signaling pathway_Homo sapiens_hsa041150.88546998
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87379167
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87366337
51Nicotine addiction_Homo sapiens_hsa050330.79046417
52N-Glycan biosynthesis_Homo sapiens_hsa005100.78965811
53Pyruvate metabolism_Homo sapiens_hsa006200.78472890
54Fatty acid metabolism_Homo sapiens_hsa012120.76421375
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76398968
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76293640
57mRNA surveillance pathway_Homo sapiens_hsa030150.76216194
58Lysine degradation_Homo sapiens_hsa003100.74293836
59Primary immunodeficiency_Homo sapiens_hsa053400.73019802
60Type I diabetes mellitus_Homo sapiens_hsa049400.67546023
61Fatty acid biosynthesis_Homo sapiens_hsa000610.66036134
62Taste transduction_Homo sapiens_hsa047420.63533392
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63484252
64Metabolic pathways_Homo sapiens_hsa011000.62905371
65Dorso-ventral axis formation_Homo sapiens_hsa043200.61729334
66Caffeine metabolism_Homo sapiens_hsa002320.61544056
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57723991
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57291453
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54091072
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53539270
71Sphingolipid metabolism_Homo sapiens_hsa006000.47994220
72Peroxisome_Homo sapiens_hsa041460.46783337
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44089689
74Allograft rejection_Homo sapiens_hsa053300.43711800
75Circadian rhythm_Homo sapiens_hsa047100.43626673
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.43186600
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42997750
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42328315
79Fatty acid degradation_Homo sapiens_hsa000710.42045800
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.41640605
81Retinol metabolism_Homo sapiens_hsa008300.41523100
82Olfactory transduction_Homo sapiens_hsa047400.41190250
83TGF-beta signaling pathway_Homo sapiens_hsa043500.41012724
84Cardiac muscle contraction_Homo sapiens_hsa042600.39594211
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.39107555
86Vitamin B6 metabolism_Homo sapiens_hsa007500.38655073
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37031801
88Epstein-Barr virus infection_Homo sapiens_hsa051690.35986487
89Graft-versus-host disease_Homo sapiens_hsa053320.35944617
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35420526
91Autoimmune thyroid disease_Homo sapiens_hsa053200.34816044
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32751919
93Nitrogen metabolism_Homo sapiens_hsa009100.32616619
94Herpes simplex infection_Homo sapiens_hsa051680.31078592
95Chemical carcinogenesis_Homo sapiens_hsa052040.26959011
96Sulfur metabolism_Homo sapiens_hsa009200.26852905
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.26846739
98Measles_Homo sapiens_hsa051620.26806320
99Rheumatoid arthritis_Homo sapiens_hsa053230.23708351
100Legionellosis_Homo sapiens_hsa051340.22522461

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