TYW3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW3 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.71667790
2regulation of mitochondrial translation (GO:0070129)4.68459318
3ribosomal large subunit biogenesis (GO:0042273)4.59722471
4chaperone-mediated protein transport (GO:0072321)4.55627274
5proteasome assembly (GO:0043248)4.54338433
6ribosomal small subunit biogenesis (GO:0042274)4.40608727
7L-serine metabolic process (GO:0006563)4.29037151
8nucleobase biosynthetic process (GO:0046112)4.12403933
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.07137258
10purine nucleobase biosynthetic process (GO:0009113)4.03023279
11DNA double-strand break processing (GO:0000729)3.98071997
12tRNA methylation (GO:0030488)3.97251310
13rRNA modification (GO:0000154)3.92136796
14folic acid-containing compound biosynthetic process (GO:0009396)3.90429105
15maturation of 5.8S rRNA (GO:0000460)3.79292861
16establishment of integrated proviral latency (GO:0075713)3.77975083
17translational termination (GO:0006415)3.76897504
18rRNA processing (GO:0006364)3.76541449
19respiratory chain complex IV assembly (GO:0008535)3.71983464
20aminoglycoside antibiotic metabolic process (GO:0030647)3.68593591
21spliceosomal snRNP assembly (GO:0000387)3.68441962
22viral transcription (GO:0019083)3.66835930
23maturation of SSU-rRNA (GO:0030490)3.65111030
24rRNA metabolic process (GO:0016072)3.65038577
25RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.64710838
26tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.64710838
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.62224031
28cytochrome complex assembly (GO:0017004)3.59742987
29rRNA methylation (GO:0031167)3.58788858
30SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.57415379
31cotranslational protein targeting to membrane (GO:0006613)3.54509484
32mitotic metaphase plate congression (GO:0007080)3.50402271
33protein targeting to ER (GO:0045047)3.50214476
34serine family amino acid biosynthetic process (GO:0009070)3.48065860
35DNA replication checkpoint (GO:0000076)3.45171723
36translation (GO:0006412)3.45166771
37DNA deamination (GO:0045006)3.45067046
38positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.42851588
39regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.42602346
40regulation of mitotic spindle checkpoint (GO:1903504)3.42602346
41DNA strand elongation involved in DNA replication (GO:0006271)3.42374935
42anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.41553666
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.39888460
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.39472639
45translational initiation (GO:0006413)3.38969865
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.38552757
47nuclear pore complex assembly (GO:0051292)3.37794389
48histone H2A acetylation (GO:0043968)3.37760723
49somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.35599717
50somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.35599717
51isotype switching (GO:0045190)3.35599717
52telomere maintenance via semi-conservative replication (GO:0032201)3.34261042
53protein localization to kinetochore (GO:0034501)3.33700910
54mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.29105498
55CENP-A containing nucleosome assembly (GO:0034080)3.28548891
56replication fork processing (GO:0031297)3.28442540
57nuclear pore organization (GO:0006999)3.26327135
58DNA strand elongation (GO:0022616)3.25272396
59negative regulation of ligase activity (GO:0051352)3.25150400
60negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.25150400
61pteridine-containing compound biosynthetic process (GO:0042559)3.24843333
62DNA damage response, detection of DNA damage (GO:0042769)3.24255637
63mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.24014275
64mitochondrial respiratory chain complex I assembly (GO:0032981)3.24014275
65NADH dehydrogenase complex assembly (GO:0010257)3.24014275
66protein targeting to mitochondrion (GO:0006626)3.23885405
67protein localization to endoplasmic reticulum (GO:0070972)3.23812401
68viral mRNA export from host cell nucleus (GO:0046784)3.23278482
69translational elongation (GO:0006414)3.22826150
70respiratory electron transport chain (GO:0022904)3.21096614
71DNA unwinding involved in DNA replication (GO:0006268)3.19673697
72non-recombinational repair (GO:0000726)3.19079348
73double-strand break repair via nonhomologous end joining (GO:0006303)3.19079348
74nucleotide-excision repair, DNA gap filling (GO:0006297)3.18861703
757-methylguanosine RNA capping (GO:0009452)3.18081906
76RNA capping (GO:0036260)3.18081906
77ribosome biogenesis (GO:0042254)3.17815348
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16527884
79DNA replication initiation (GO:0006270)3.16207793
80electron transport chain (GO:0022900)3.13379908
817-methylguanosine mRNA capping (GO:0006370)3.10669501
82ATP synthesis coupled proton transport (GO:0015986)3.10468354
83energy coupled proton transport, down electrochemical gradient (GO:0015985)3.10468354
84somatic hypermutation of immunoglobulin genes (GO:0016446)3.06004146
85somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06004146
86formation of translation preinitiation complex (GO:0001731)3.04583163
87establishment of protein localization to mitochondrion (GO:0072655)3.04419747
88transcription from mitochondrial promoter (GO:0006390)3.04335277
89chromatin remodeling at centromere (GO:0031055)3.03744177
90protein localization to chromosome, centromeric region (GO:0071459)3.02359958
91spliceosomal complex assembly (GO:0000245)3.01990442
92histone mRNA metabolic process (GO:0008334)3.01989014
93nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.01712939
94synapsis (GO:0007129)3.01601633
95positive regulation of histone H3-K4 methylation (GO:0051571)2.99659181
96telomere maintenance via telomerase (GO:0007004)2.98644991
97regulation of chromatin binding (GO:0035561)2.98631982
98ribosome assembly (GO:0042255)2.98557812
99positive regulation of ligase activity (GO:0051351)2.98213772
100mitochondrial RNA metabolic process (GO:0000959)2.97258837
101oxidative phosphorylation (GO:0006119)2.96950250
102protein localization to mitochondrion (GO:0070585)2.96025280
103negative regulation of DNA-dependent DNA replication (GO:2000104)2.95835769
104transcription elongation from RNA polymerase I promoter (GO:0006362)2.93696680
105metaphase plate congression (GO:0051310)2.91474144
106exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90875652
107protein complex biogenesis (GO:0070271)2.88376266
108telomere maintenance via recombination (GO:0000722)2.88102066
109establishment of chromosome localization (GO:0051303)2.88000946
110DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.87751569
111regulation of cellular amino acid metabolic process (GO:0006521)2.87523033
112ribonucleoprotein complex biogenesis (GO:0022613)2.87307322
113kinetochore organization (GO:0051383)2.87077811
114signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.85533584
115signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.85533584
116signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.85533584
117termination of RNA polymerase I transcription (GO:0006363)2.84792676
118signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.84783425
119intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.84783425
120kinetochore assembly (GO:0051382)2.82463307
121transcription-coupled nucleotide-excision repair (GO:0006283)2.82261000
122DNA catabolic process, exonucleolytic (GO:0000738)2.79630070
123cullin deneddylation (GO:0010388)2.79222741
124transcription elongation from RNA polymerase III promoter (GO:0006385)2.78700203
125termination of RNA polymerase III transcription (GO:0006386)2.78700203
126mitotic recombination (GO:0006312)2.78230944
127protein deneddylation (GO:0000338)2.77376199
128mitochondrial respiratory chain complex assembly (GO:0033108)2.77044861
129signal transduction involved in DNA damage checkpoint (GO:0072422)2.76672435
130signal transduction involved in DNA integrity checkpoint (GO:0072401)2.76672435
131regulation of ubiquitin-protein transferase activity (GO:0051438)2.76128840
132deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.75263672
133DNA replication-independent nucleosome assembly (GO:0006336)2.75160827
134DNA replication-independent nucleosome organization (GO:0034724)2.75160827
135nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.74883339
136telomere maintenance via telomere lengthening (GO:0010833)2.74317822
137tRNA modification (GO:0006400)2.73065107
138signal transduction involved in cell cycle checkpoint (GO:0072395)2.72485162
139establishment of viral latency (GO:0019043)2.71961913
140pseudouridine synthesis (GO:0001522)2.69429419
141negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.67195960
142negative regulation of DNA-templated transcription, elongation (GO:0032785)2.67195960
143cellular component biogenesis (GO:0044085)2.66195762
144histone exchange (GO:0043486)2.65623816
145transcription from RNA polymerase I promoter (GO:0006360)2.63268623
146regulation of ligase activity (GO:0051340)2.62484738
147positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.60234057
148cell cycle G1/S phase transition (GO:0044843)2.59911040
149G1/S transition of mitotic cell cycle (GO:0000082)2.59911040
150negative regulation of sister chromatid segregation (GO:0033046)2.59533576
151negative regulation of mitotic sister chromatid separation (GO:2000816)2.59533576
152negative regulation of mitotic sister chromatid segregation (GO:0033048)2.59533576

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.23478239
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.38304447
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.94147524
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.75823256
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.58004865
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.42694606
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.18824518
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.13908677
9* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.05079042
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.03881718
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.98405755
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.95574551
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94715994
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90544239
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.84169084
16AR_21909140_ChIP-Seq_LNCAP_Human2.80568263
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.76835396
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74090749
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.72520015
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.58565581
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.53040836
22* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.33069633
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.33036356
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.25982863
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24644232
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.19972155
27XRN2_22483619_ChIP-Seq_HELA_Human2.19268681
28ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.11854039
29FOXM1_23109430_ChIP-Seq_U2OS_Human2.10652754
30YY1_21170310_ChIP-Seq_MESCs_Mouse2.10564724
31* VDR_23849224_ChIP-Seq_CD4+_Human2.08264277
32* TTF2_22483619_ChIP-Seq_HELA_Human2.01260171
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.98007915
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.95742380
35* FOXP3_21729870_ChIP-Seq_TREG_Human1.94161033
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91308408
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.90555972
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86363204
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85038744
40DCP1A_22483619_ChIP-Seq_HELA_Human1.82193541
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81991418
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80214397
43GABP_19822575_ChIP-Seq_HepG2_Human1.78981707
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.77293833
45* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72005952
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68042992
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.62231879
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58577821
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56257851
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55701775
51CIITA_25753668_ChIP-Seq_RAJI_Human1.54946663
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51689406
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49118026
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48868999
55ELK1_19687146_ChIP-ChIP_HELA_Human1.48553172
56KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42060820
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33588174
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29387807
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28081502
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.26529202
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.25128553
62SOX2_16153702_ChIP-ChIP_HESCs_Human1.24596000
63IRF1_19129219_ChIP-ChIP_H3396_Human1.22816471
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22665907
65IGF1R_20145208_ChIP-Seq_DFB_Human1.19492264
66ZNF274_21170338_ChIP-Seq_K562_Hela1.19430550
67NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.18700886
68SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.17421311
69TAF15_26573619_Chip-Seq_HEK293_Human1.17347446
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.17327686
71TFEB_21752829_ChIP-Seq_HELA_Human1.17207876
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14107572
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14081246
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13944251
75FUS_26573619_Chip-Seq_HEK293_Human1.13387806
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12182826
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10344000
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09983539
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08700016
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07411857
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07156974
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06413232
83* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06341211
84NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.05280934
85NANOG_16153702_ChIP-ChIP_HESCs_Human1.02991309
86ELK1_22589737_ChIP-Seq_MCF10A_Human1.01492604
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99361957
88NOTCH1_21737748_ChIP-Seq_TLL_Human0.98534256
89EWS_26573619_Chip-Seq_HEK293_Human0.97603304
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97070506
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96193188
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95050539
93NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93862699
94* MYC_18940864_ChIP-ChIP_HL60_Human0.91684277
95PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89034429
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88422126
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87573924
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87240420
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86306545
100* KDM5A_27292631_Chip-Seq_BREAST_Human0.84503367
101GBX2_23144817_ChIP-Seq_PC3_Human0.83576167
102SOX17_20123909_ChIP-Seq_XEN_Mouse0.83026620
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82815189
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82443417
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81526162
106ERG_20887958_ChIP-Seq_HPC-7_Mouse0.79062435
107SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.78948107
108SOX9_26525672_Chip-Seq_HEART_Mouse0.78754798
109VDR_22108803_ChIP-Seq_LS180_Human0.78531755
110ELF5_23300383_ChIP-Seq_T47D_Human0.78253014
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78003602
112SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.76813338
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75146660
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.73921006
115TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.72418002
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.71137371
117OCT4_18692474_ChIP-Seq_MEFs_Mouse0.70325694
118POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.69946486
119TP53_22573176_ChIP-Seq_HFKS_Human0.68811027
120GATA1_22025678_ChIP-Seq_K562_Human0.68793699
121ER_23166858_ChIP-Seq_MCF-7_Human0.68363024
122DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.68088981
123GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.65709497
124* PHF8_20622853_ChIP-Seq_HELA_Human0.65450532
125CHD1_26751641_Chip-Seq_LNCaP_Human0.63149505

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.56096199
2MP0003693_abnormal_embryo_hatching3.25289050
3MP0008058_abnormal_DNA_repair2.99357082
4MP0010094_abnormal_chromosome_stability2.98970944
5MP0004043_abnormal_pH_regulation2.66166944
6MP0001529_abnormal_vocalization2.52006859
7MP0003122_maternal_imprinting2.48500174
8MP0003111_abnormal_nucleus_morphology2.47835788
9MP0003806_abnormal_nucleotide_metabolis2.47015450
10MP0004957_abnormal_blastocyst_morpholog2.42873597
11MP0003123_paternal_imprinting2.34021956
12MP0003077_abnormal_cell_cycle2.28280066
13MP0003938_abnormal_ear_development2.26894622
14MP0008877_abnormal_DNA_methylation2.23381881
15MP0003121_genomic_imprinting2.22056582
16MP0008932_abnormal_embryonic_tissue2.20542617
17MP0002837_dystrophic_cardiac_calcinosis2.18162834
18MP0005646_abnormal_pituitary_gland2.09230989
19MP0005645_abnormal_hypothalamus_physiol2.05458476
20MP0002163_abnormal_gland_morphology2.00949929
21MP0009046_muscle_twitch2.00363545
22MP0001293_anophthalmia1.89728560
23MP0010307_abnormal_tumor_latency1.80318602
24MP0008007_abnormal_cellular_replicative1.74365948
25MP0001905_abnormal_dopamine_level1.71815563
26MP0003315_abnormal_perineum_morphology1.70487825
27MP0003186_abnormal_redox_activity1.66791693
28MP0008057_abnormal_DNA_replication1.63807404
29MP0003941_abnormal_skin_development1.62264422
30MP0003942_abnormal_urinary_system1.59969064
31MP0000631_abnormal_neuroendocrine_gland1.59672635
32MP0006072_abnormal_retinal_apoptosis1.53290762
33MP0004859_abnormal_synaptic_plasticity1.49117276
34MP0005379_endocrine/exocrine_gland_phen1.48657810
35MP0002132_abnormal_respiratory_system1.46594290
36MP0000372_irregular_coat_pigmentation1.44048658
37MP0003878_abnormal_ear_physiology1.41907907
38MP0005377_hearing/vestibular/ear_phenot1.41907907
39MP0002102_abnormal_ear_morphology1.41714185
40MP0003646_muscle_fatigue1.41170439
41MP0003718_maternal_effect1.40816727
42MP0009697_abnormal_copulation1.38786152
43MP0001485_abnormal_pinna_reflex1.37034464
44MP0005075_abnormal_melanosome_morpholog1.37023557
45MP0002751_abnormal_autonomic_nervous1.36608327
46MP0002396_abnormal_hematopoietic_system1.35527836
47MP0003635_abnormal_synaptic_transmissio1.32768999
48MP0005174_abnormal_tail_pigmentation1.32405958
49MP0004133_heterotaxia1.30526479
50MP0009379_abnormal_foot_pigmentation1.30003958
51MP0001730_embryonic_growth_arrest1.24355515
52MP0003786_premature_aging1.23799535
53MP0005408_hypopigmentation1.18964741
54MP0000313_abnormal_cell_death1.18412814
55MP0002064_seizures1.16436224
56MP0000049_abnormal_middle_ear1.14985313
57MP0001188_hyperpigmentation1.14730643
58MP0002006_tumorigenesis1.14297156
59MP0003937_abnormal_limbs/digits/tail_de1.14154371
60MP0001968_abnormal_touch/_nociception1.13829265
61MP0005171_absent_coat_pigmentation1.13319640
62MP0002876_abnormal_thyroid_physiology1.12985400
63MP0002736_abnormal_nociception_after1.12942238
64MP0002272_abnormal_nervous_system1.12431626
65MP0002063_abnormal_learning/memory/cond1.12329551
66MP0003880_abnormal_central_pattern1.12200533
67MP0001486_abnormal_startle_reflex1.09808175
68MP0001697_abnormal_embryo_size1.09301040
69MP0009745_abnormal_behavioral_response1.08894590
70MP0004142_abnormal_muscle_tone1.07202013
71MP0002009_preneoplasia1.07065021
72MP0009672_abnormal_birth_weight1.06797686
73MP0001929_abnormal_gametogenesis1.06235550
74MP0002234_abnormal_pharynx_morphology1.05873221
75MP0002160_abnormal_reproductive_system1.05041659
76MP0003195_calcinosis1.04733765
77MP0002095_abnormal_skin_pigmentation1.04671768
78MP0002166_altered_tumor_susceptibility1.03862642
79MP0002877_abnormal_melanocyte_morpholog1.03591498
80MP0003861_abnormal_nervous_system1.03449484
81MP0008872_abnormal_physiological_respon1.01154968
82MP0003787_abnormal_imprinting1.00372473
83MP0002572_abnormal_emotion/affect_behav0.99968165
84MP0002085_abnormal_embryonic_tissue0.99347702
85MP0000350_abnormal_cell_proliferation0.98452825
86MP0009333_abnormal_splenocyte_physiolog0.97841422
87MP0000534_abnormal_ureter_morphology0.97774597
88MP0002019_abnormal_tumor_incidence0.97302744
89MP0001348_abnormal_lacrimal_gland0.97138244
90MP0004084_abnormal_cardiac_muscle0.96980812
91MP0001672_abnormal_embryogenesis/_devel0.96890773
92MP0005380_embryogenesis_phenotype0.96890773
93MP0000569_abnormal_digit_pigmentation0.96834988
94MP0001764_abnormal_homeostasis0.96691819
95MP0002067_abnormal_sensory_capabilities0.95448781
96MP0000653_abnormal_sex_gland0.95263607
97MP0003567_abnormal_fetal_cardiomyocyte0.94779249
98MP0006035_abnormal_mitochondrial_morpho0.93527142
99MP0001661_extended_life_span0.92490514
100MP0002210_abnormal_sex_determination0.91890697
101MP0010030_abnormal_orbit_morphology0.91577660
102MP0000358_abnormal_cell_content/0.90611433
103MP0000778_abnormal_nervous_system0.89909940
104MP0005220_abnormal_exocrine_pancreas0.89709893
105MP0003879_abnormal_hair_cell0.89313732
106MP0010352_gastrointestinal_tract_polyps0.87779838
107MP0005386_behavior/neurological_phenoty0.87607070
108MP0004924_abnormal_behavior0.87607070
109MP0002152_abnormal_brain_morphology0.87398374
110MP0003943_abnormal_hepatobiliary_system0.87231639
111MP0001919_abnormal_reproductive_system0.87043797
112MP0008789_abnormal_olfactory_epithelium0.86990320
113MP0001853_heart_inflammation0.86422529
114MP0003984_embryonic_growth_retardation0.85617059
115MP0000537_abnormal_urethra_morphology0.85280258
116MP0002088_abnormal_embryonic_growth/wei0.85203929
117MP0002735_abnormal_chemical_nociception0.84035871
118MP0005395_other_phenotype0.83716831
119MP0002184_abnormal_innervation0.83701482
120MP0002557_abnormal_social/conspecific_i0.81726541
121MP0005409_darkened_coat_color0.80532674
122MP0002080_prenatal_lethality0.80448151
123MP0004233_abnormal_muscle_weight0.80227214
124MP0006036_abnormal_mitochondrial_physio0.78979624
125MP0005332_abnormal_amino_acid0.77791059
126MP0005389_reproductive_system_phenotype0.75904522
127MP0002938_white_spotting0.75777592
128MP0004811_abnormal_neuron_physiology0.75518578
129MP0001145_abnormal_male_reproductive0.75460424
130MP0003890_abnormal_embryonic-extraembry0.75291525
131MP0004215_abnormal_myocardial_fiber0.75190183
132MP0002233_abnormal_nose_morphology0.74808380
133MP0003950_abnormal_plasma_membrane0.73499177
134MP0003763_abnormal_thymus_physiology0.73354333
135MP0003119_abnormal_digestive_system0.72780062
136MP0001119_abnormal_female_reproductive0.72544890
137MP0002734_abnormal_mechanical_nocicepti0.72168185
138MP0003011_delayed_dark_adaptation0.72063041
139MP0002084_abnormal_developmental_patter0.71765304
140MP0001881_abnormal_mammary_gland0.71507706
141MP0005266_abnormal_metabolism0.67640846
142MP0005253_abnormal_eye_physiology0.65836994
143MP0008775_abnormal_heart_ventricle0.65653346
144MP0003136_yellow_coat_color0.65323029
145MP0002693_abnormal_pancreas_physiology0.64418229
146MP0005084_abnormal_gallbladder_morpholo0.62602714
147MP0001286_abnormal_eye_development0.62453295
148MP0000427_abnormal_hair_cycle0.62115005
149MP0003698_abnormal_male_reproductive0.60433373
150MP0004197_abnormal_fetal_growth/weight/0.59170237
151MP0008875_abnormal_xenobiotic_pharmacok0.59082219

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.00106543
2Rhabdomyosarcoma (HP:0002859)3.69285772
3Breast hypoplasia (HP:0003187)3.42414457
4Reticulocytopenia (HP:0001896)3.40946981
5Cerebral edema (HP:0002181)3.23364855
6Pheochromocytoma (HP:0002666)3.21085096
7Mitochondrial inheritance (HP:0001427)3.18340223
8Abnormality of the ileum (HP:0001549)3.10663223
93-Methylglutaconic aciduria (HP:0003535)3.09977004
10Hepatocellular necrosis (HP:0001404)3.09908750
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.09709723
12Abnormality of cells of the erythroid lineage (HP:0012130)3.08982392
13Abnormal mitochondria in muscle tissue (HP:0008316)3.07117302
14Acute necrotizing encephalopathy (HP:0006965)3.03466977
15Astrocytoma (HP:0009592)2.99292023
16Abnormality of the astrocytes (HP:0100707)2.99292023
17High anterior hairline (HP:0009890)2.98691425
18Abnormality of the preputium (HP:0100587)2.97644754
19Neoplasm of striated muscle (HP:0009728)2.94923204
20Abnormal number of erythroid precursors (HP:0012131)2.92379906
21Severe visual impairment (HP:0001141)2.91720050
22Absent thumb (HP:0009777)2.91345048
23Neuroendocrine neoplasm (HP:0100634)2.85885919
24Colon cancer (HP:0003003)2.84090437
25Increased CSF lactate (HP:0002490)2.82432153
26Abnormality of methionine metabolism (HP:0010901)2.77842422
27Glioma (HP:0009733)2.76685954
28Abnormality of alanine metabolism (HP:0010916)2.76240941
29Hyperalaninemia (HP:0003348)2.76240941
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.76240941
31Renal cortical cysts (HP:0000803)2.73151712
32Abdominal situs inversus (HP:0003363)2.72380967
33Abnormality of abdominal situs (HP:0011620)2.72380967
34Cerebral hypomyelination (HP:0006808)2.70051869
35Increased intramyocellular lipid droplets (HP:0012240)2.65885731
36Hypomagnesemia (HP:0002917)2.65304367
37Abnormality of the renal collecting system (HP:0004742)2.64793409
38Hyperventilation (HP:0002883)2.64752709
39Hyperglycinemia (HP:0002154)2.61719579
40Abnormality of glycolysis (HP:0004366)2.56679658
41Increased serum pyruvate (HP:0003542)2.56679658
42Type I transferrin isoform profile (HP:0003642)2.53581282
43Acute encephalopathy (HP:0006846)2.52927339
44Duplicated collecting system (HP:0000081)2.45151424
45Microvesicular hepatic steatosis (HP:0001414)2.42712084
46Abnormality of magnesium homeostasis (HP:0004921)2.40436000
47Pancreatic islet-cell hyperplasia (HP:0004510)2.35079044
48Hepatic necrosis (HP:0002605)2.34306398
49Abnormal number of incisors (HP:0011064)2.32627144
50Chromsome breakage (HP:0040012)2.31670805
51Reduced antithrombin III activity (HP:0001976)2.31044174
52Patellar aplasia (HP:0006443)2.30464644
53Septo-optic dysplasia (HP:0100842)2.28716867
54Fetal akinesia sequence (HP:0001989)2.26965166
55Increased serum lactate (HP:0002151)2.26499966
56Chromosomal breakage induced by crosslinking agents (HP:0003221)2.26397499
57Duodenal stenosis (HP:0100867)2.25044806
58Small intestinal stenosis (HP:0012848)2.25044806
59Absent radius (HP:0003974)2.24351805
60Increased hepatocellular lipid droplets (HP:0006565)2.24194807
61Myelodysplasia (HP:0002863)2.23585715
62Ectopic kidney (HP:0000086)2.23278542
63Exertional dyspnea (HP:0002875)2.23009282
64Carpal bone hypoplasia (HP:0001498)2.22236753
65Postnatal microcephaly (HP:0005484)2.20631784
66Sensory axonal neuropathy (HP:0003390)2.20575721
67Methylmalonic acidemia (HP:0002912)2.19970144
68Increased circulating renin level (HP:0000848)2.18151930
69Pancreatic cysts (HP:0001737)2.18119674
70Abnormality of aspartate family amino acid metabolism (HP:0010899)2.17935665
71Hypoglycemic coma (HP:0001325)2.17595858
72Progressive macrocephaly (HP:0004481)2.16998571
73Aplasia/Hypoplasia of the patella (HP:0006498)2.16046769
74Absent forearm bone (HP:0003953)2.15427420
75Aplasia involving forearm bones (HP:0009822)2.15427420
76Leukodystrophy (HP:0002415)2.14576058
77Facial cleft (HP:0002006)2.12947598
78Volvulus (HP:0002580)2.12403775
79Atonic seizures (HP:0010819)2.11013784
80Hypoplasia of the pons (HP:0012110)2.10924118
81Abnormality of the pons (HP:0007361)2.10882344
82Emotional lability (HP:0000712)2.10249961
83Abnormal lung lobation (HP:0002101)2.09587904
84Sloping forehead (HP:0000340)2.08523972
85Increased muscle lipid content (HP:0009058)2.07018551
86Abnormality of the labia minora (HP:0012880)2.05828753
87Pallor (HP:0000980)2.04527031
88Clubbing of toes (HP:0100760)2.03533064
89Horseshoe kidney (HP:0000085)2.03403252
90Abnormality of the renal cortex (HP:0011035)2.02310583
91Lethargy (HP:0001254)2.02251949
92Polyuria (HP:0000103)2.01286159
93Respiratory difficulties (HP:0002880)2.01178016
94Abnormality of chromosome segregation (HP:0002916)2.00866744
95Congenital, generalized hypertrichosis (HP:0004540)1.99033458
96Impulsivity (HP:0100710)1.98203968
97Abnormality of the duodenum (HP:0002246)1.97864511
98Pancytopenia (HP:0001876)1.96116483
99Cleft eyelid (HP:0000625)1.95538127
100Aplastic anemia (HP:0001915)1.93553972
101Hyperinsulinemic hypoglycemia (HP:0000825)1.93235649
102Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.93064299
103Abnormality of serum amino acid levels (HP:0003112)1.93024136
104Metabolic alkalosis (HP:0200114)1.92008607
105Unsteady gait (HP:0002317)1.90966402
106Duplication of thumb phalanx (HP:0009942)1.90325658
107Ependymoma (HP:0002888)1.89646375
108Abnormal protein glycosylation (HP:0012346)1.89610521
109Abnormal glycosylation (HP:0012345)1.89610521
110Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89610521
111Abnormal protein N-linked glycosylation (HP:0012347)1.89610521
112Lactic acidosis (HP:0003128)1.85082878
113Exercise intolerance (HP:0003546)1.84588894
114Self-mutilation (HP:0000742)1.84486465
115Generalized aminoaciduria (HP:0002909)1.84209831
116Cutaneous melanoma (HP:0012056)1.83155099
117Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82910182
118Pancreatic fibrosis (HP:0100732)1.82736409
119Hypoplastic pelvis (HP:0008839)1.82544515
120Supernumerary spleens (HP:0009799)1.82374696
121Ureteral duplication (HP:0000073)1.82338855
122Abnormality of renal resorption (HP:0011038)1.82295514
123Rectovaginal fistula (HP:0000143)1.82249651
124Rectal fistula (HP:0100590)1.82249651
125Abnormal biliary tract physiology (HP:0012439)1.81647447
126Bile duct proliferation (HP:0001408)1.81647447
127Broad-based gait (HP:0002136)1.81045917
128Hyperglycinuria (HP:0003108)1.79702509
129Focal motor seizures (HP:0011153)1.79472818
130Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.79464402
131Congenital stationary night blindness (HP:0007642)1.78005601
132Optic disc pallor (HP:0000543)1.77653500
133Lipid accumulation in hepatocytes (HP:0006561)1.77495494
134Meckel diverticulum (HP:0002245)1.76152921
135Megaloblastic anemia (HP:0001889)1.74222414
136CNS demyelination (HP:0007305)1.73996576
137Methylmalonic aciduria (HP:0012120)1.73744602
138Oral leukoplakia (HP:0002745)1.72573620
139Triphalangeal thumb (HP:0001199)1.72545430
140Abnormality of the carotid arteries (HP:0005344)1.71966897
141Abnormality of DNA repair (HP:0003254)1.71386416
142Abnormality of chromosome stability (HP:0003220)1.70996106
143Abnormality of serine family amino acid metabolism (HP:0010894)1.70469081
144Abnormality of glycine metabolism (HP:0010895)1.70469081
145Aplasia/Hypoplasia of the sacrum (HP:0008517)1.69672226
146Macrocytic anemia (HP:0001972)1.69554929
147Renal Fanconi syndrome (HP:0001994)1.69362041
148Rough bone trabeculation (HP:0100670)1.68921184
149Intestinal fistula (HP:0100819)1.67709513
150Preaxial hand polydactyly (HP:0001177)1.67408159
151Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.66773139
152Squamous cell carcinoma (HP:0002860)1.66401909
153Decreased activity of mitochondrial respiratory chain (HP:0008972)1.65153801
154Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.65153801
155Midline defect of the nose (HP:0004122)1.64273059
156Abnormality of the parathyroid morphology (HP:0011766)1.63604219
157Parakeratosis (HP:0001036)1.63156836
158Respiratory failure (HP:0002878)1.63137029

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B7.34669255
2LATS13.90732943
3NUAK13.74983611
4BUB13.22372887
5VRK22.74199414
6TSSK62.72918635
7MST42.70994688
8WEE12.68556622
9PBK2.61239888
10STK162.34802902
11WNK32.34233035
12SCYL22.27010123
13EIF2AK12.12129937
14MKNK22.09261101
15TAF12.07172803
16MKNK12.01778686
17FRK1.97026791
18SRPK11.86150227
19CASK1.80136560
20CDC71.79484256
21SIK31.77196497
22DYRK31.69432567
23STK391.63570894
24BMPR1B1.61477130
25ACVR1B1.57664589
26NEK11.57234181
27ZAK1.52389226
28PLK31.52193826
29PNCK1.46793879
30OXSR11.43799190
31NME21.36909150
32TLK11.23547327
33VRK11.21767733
34TESK21.17879138
35MAP2K71.17487795
36CCNB11.16453279
37PLK11.13905009
38PDK21.12489374
39PASK1.10584673
40RPS6KB21.08404771
41TRIM281.02929715
42AKT31.02406245
43STK31.02278760
44BRD41.00322103
45STK38L0.99695996
46GRK10.96661821
47ATR0.96462349
48SGK20.92877580
49TTK0.92712530
50ATM0.90818782
51WNK40.90763401
52STK40.88594288
53DYRK20.86478677
54AURKA0.86046718
55MAPKAPK50.85159025
56EIF2AK30.83814039
57SGK4940.81534647
58SGK2230.81534647
59NEK20.80993946
60MARK10.76886072
61CDK70.75447803
62STK240.75284736
63YES10.74803016
64PLK40.71155204
65TEC0.70217437
66AURKB0.69866734
67CDK30.69136375
68NME10.68994933
69CSNK1G30.68861304
70PLK20.66480773
71MAP4K20.66448477
72TGFBR10.64887837
73MAP3K40.64579653
74PDK40.64240816
75PDK30.64240816
76DYRK1A0.62977494
77PINK10.61752279
78EPHB20.61255544
79RPS6KA40.61147383
80CDK80.57648245
81ADRBK20.54473611
82CHEK20.54333854
83RPS6KA50.54097802
84CSNK1E0.53492093
85CSNK1G10.53214541
86MAP3K20.51535585
87CSF1R0.51439791
88CSNK2A10.50034191
89BCR0.49056058
90RPS6KC10.48965072
91RPS6KL10.48965072
92PRKCG0.46483103
93CDK10.46253237
94BRSK20.45824808
95CDK190.45741643
96DAPK10.45469849
97EEF2K0.43944617
98CLK10.43774300
99BRSK10.40888878
100ARAF0.40824447
101CHEK10.40697847
102OBSCN0.40478790
103CDK180.40379491
104MAPK130.39939519
105CSNK1G20.39655799
106CDK40.38657846
107EPHA20.38413998
108PRKCI0.38255860
109MARK30.38029483
110ERBB30.37735590
111CDK20.37494011
112CDK140.37429538
113CSNK2A20.37290550
114CAMK2B0.37118519
115TRPM70.37080709
116MAP3K140.36951939
117AKT20.36422988
118PAK40.36365422
119ILK0.35870704
120EPHA40.35541939
121TNIK0.35524404
122GRK50.34841249
123CDK150.34753974
124BRAF0.34620336
125RPS6KA60.34539893
126PRKDC0.34368887
127EIF2AK20.33148369
128RAF10.32308454
129SGK30.31783328
130STK380.31416437
131ALK0.31177842
132MAPK90.31059739
133LIMK10.30499755
134RPS6KA20.30384366
135CDK11A0.29954817
136BMPR20.29556044
137MAP3K120.29210835
138PRKCQ0.28970089
139CSNK1A1L0.26868429
140CDK90.26469801
141CAMK1G0.25965421
142MAPKAPK30.25056234
143RPS6KB10.23157435
144ERBB40.22332004

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.27497119
2Proteasome_Homo sapiens_hsa030504.04367141
3Mismatch repair_Homo sapiens_hsa034303.37627915
4RNA polymerase_Homo sapiens_hsa030203.36996918
5Base excision repair_Homo sapiens_hsa034103.20042647
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.08268149
7Spliceosome_Homo sapiens_hsa030403.01574397
8Ribosome_Homo sapiens_hsa030102.81870123
9Nucleotide excision repair_Homo sapiens_hsa034202.81718439
10Pyrimidine metabolism_Homo sapiens_hsa002402.49140592
11Homologous recombination_Homo sapiens_hsa034402.40399948
12Oxidative phosphorylation_Homo sapiens_hsa001902.39221170
13Parkinsons disease_Homo sapiens_hsa050122.36367402
14RNA transport_Homo sapiens_hsa030132.32440660
15Fanconi anemia pathway_Homo sapiens_hsa034601.94242472
16Huntingtons disease_Homo sapiens_hsa050161.86608434
17Cell cycle_Homo sapiens_hsa041101.79462289
18Non-homologous end-joining_Homo sapiens_hsa034501.78017090
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68937641
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62840012
21Selenocompound metabolism_Homo sapiens_hsa004501.56435041
22RNA degradation_Homo sapiens_hsa030181.56138469
23Purine metabolism_Homo sapiens_hsa002301.53571048
24Vitamin B6 metabolism_Homo sapiens_hsa007501.50636019
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47702961
26One carbon pool by folate_Homo sapiens_hsa006701.47225714
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43355334
28Basal transcription factors_Homo sapiens_hsa030221.37689862
29Glutathione metabolism_Homo sapiens_hsa004801.31308476
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.28874204
31Alzheimers disease_Homo sapiens_hsa050101.28357710
32Nicotine addiction_Homo sapiens_hsa050331.27629392
33mRNA surveillance pathway_Homo sapiens_hsa030151.22238479
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21725940
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15707686
36Collecting duct acid secretion_Homo sapiens_hsa049661.12766843
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05526298
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02728244
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01742356
40Oocyte meiosis_Homo sapiens_hsa041140.98814317
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95362055
42Synaptic vesicle cycle_Homo sapiens_hsa047210.94980727
43Phototransduction_Homo sapiens_hsa047440.87650999
44Butanoate metabolism_Homo sapiens_hsa006500.84125866
45Epstein-Barr virus infection_Homo sapiens_hsa051690.80978143
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80138303
47p53 signaling pathway_Homo sapiens_hsa041150.79699564
48Cardiac muscle contraction_Homo sapiens_hsa042600.77445790
49Nitrogen metabolism_Homo sapiens_hsa009100.74486793
50Sulfur metabolism_Homo sapiens_hsa009200.71312810
51Propanoate metabolism_Homo sapiens_hsa006400.69321997
52Biosynthesis of amino acids_Homo sapiens_hsa012300.68363314
53Carbon metabolism_Homo sapiens_hsa012000.67214770
54Basal cell carcinoma_Homo sapiens_hsa052170.66920670
55Taste transduction_Homo sapiens_hsa047420.63514430
56Fatty acid elongation_Homo sapiens_hsa000620.63123223
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63035825
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61827672
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60378453
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.58830601
61N-Glycan biosynthesis_Homo sapiens_hsa005100.58552496
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57273431
63Protein export_Homo sapiens_hsa030600.56745379
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55397679
65Pyruvate metabolism_Homo sapiens_hsa006200.55050403
66Sulfur relay system_Homo sapiens_hsa041220.54807398
67Metabolic pathways_Homo sapiens_hsa011000.54411950
68Wnt signaling pathway_Homo sapiens_hsa043100.54162847
69GABAergic synapse_Homo sapiens_hsa047270.52299619
70Asthma_Homo sapiens_hsa053100.51283797
71Hedgehog signaling pathway_Homo sapiens_hsa043400.51039372
72Arginine biosynthesis_Homo sapiens_hsa002200.49928180
73Olfactory transduction_Homo sapiens_hsa047400.48691485
74Peroxisome_Homo sapiens_hsa041460.47079415
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45407220
76Morphine addiction_Homo sapiens_hsa050320.45241706
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44690543
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.43522802
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43116980
80Vibrio cholerae infection_Homo sapiens_hsa051100.41640694
81Amphetamine addiction_Homo sapiens_hsa050310.41096194
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40857901
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38489089
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38486995
85Gap junction_Homo sapiens_hsa045400.34817239
86Circadian entrainment_Homo sapiens_hsa047130.34237809
87Hippo signaling pathway_Homo sapiens_hsa043900.34090446
88Alcoholism_Homo sapiens_hsa050340.33601034
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33035659
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31532051
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.31107096
92Fatty acid degradation_Homo sapiens_hsa000710.31103272
93Tryptophan metabolism_Homo sapiens_hsa003800.30312222
94Primary immunodeficiency_Homo sapiens_hsa053400.29687670
95Lysine degradation_Homo sapiens_hsa003100.29553930
96Folate biosynthesis_Homo sapiens_hsa007900.29499221
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28489200
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28422054
99TGF-beta signaling pathway_Homo sapiens_hsa043500.28195889
100Type I diabetes mellitus_Homo sapiens_hsa049400.28118970
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27880803
102HTLV-I infection_Homo sapiens_hsa051660.27120182
103Caffeine metabolism_Homo sapiens_hsa002320.26622506
104Fructose and mannose metabolism_Homo sapiens_hsa000510.26064311
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.25809865
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25551743
107Serotonergic synapse_Homo sapiens_hsa047260.25333814
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25016674
109Fatty acid metabolism_Homo sapiens_hsa012120.24939981
110Pentose phosphate pathway_Homo sapiens_hsa000300.24565147
111Glutamatergic synapse_Homo sapiens_hsa047240.23270183
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23264858
113Arginine and proline metabolism_Homo sapiens_hsa003300.23113955
114Colorectal cancer_Homo sapiens_hsa052100.22477434
115Long-term potentiation_Homo sapiens_hsa047200.21874245
116Systemic lupus erythematosus_Homo sapiens_hsa053220.20375937
117Axon guidance_Homo sapiens_hsa043600.19985613
118Dopaminergic synapse_Homo sapiens_hsa047280.18930933
119Autoimmune thyroid disease_Homo sapiens_hsa053200.18365278
120Tight junction_Homo sapiens_hsa045300.18126023
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17975801
122Tyrosine metabolism_Homo sapiens_hsa003500.16493174
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.15889797
124Allograft rejection_Homo sapiens_hsa053300.15883165
125Circadian rhythm_Homo sapiens_hsa047100.15515603
126Herpes simplex infection_Homo sapiens_hsa051680.14609624
127Antigen processing and presentation_Homo sapiens_hsa046120.14464574
128Retinol metabolism_Homo sapiens_hsa008300.14406800
129Vitamin digestion and absorption_Homo sapiens_hsa049770.14286840
130beta-Alanine metabolism_Homo sapiens_hsa004100.13450742
131Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.13285462
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.13064341
133Viral carcinogenesis_Homo sapiens_hsa052030.12211480
134Gastric acid secretion_Homo sapiens_hsa049710.11733031
135Calcium signaling pathway_Homo sapiens_hsa040200.10523654
136Endometrial cancer_Homo sapiens_hsa052130.09495710
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.08885713
138Chemical carcinogenesis_Homo sapiens_hsa052040.08571897
139Regulation of autophagy_Homo sapiens_hsa041400.07518048

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