TYW5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)6.99417273
2establishment of protein localization to mitochondrial membrane (GO:0090151)6.41126559
3protein neddylation (GO:0045116)5.27420968
4proteasome assembly (GO:0043248)5.15457649
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.96967208
6ATP synthesis coupled proton transport (GO:0015986)4.96967208
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.92265143
8response to pheromone (GO:0019236)4.79623457
97-methylguanosine mRNA capping (GO:0006370)4.78451400
10behavioral response to nicotine (GO:0035095)4.77380260
11RNA capping (GO:0036260)4.73776088
127-methylguanosine RNA capping (GO:0009452)4.73776088
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.72849784
14cullin deneddylation (GO:0010388)4.49119406
15protein targeting to mitochondrion (GO:0006626)4.26772862
16establishment of protein localization to mitochondrion (GO:0072655)4.11661893
17axon ensheathment in central nervous system (GO:0032291)4.07010308
18central nervous system myelination (GO:0022010)4.07010308
19L-fucose catabolic process (GO:0042355)4.04311869
20fucose catabolic process (GO:0019317)4.04311869
21L-fucose metabolic process (GO:0042354)4.04311869
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.98990761
23regulation of cellular amino acid metabolic process (GO:0006521)3.87391578
24protein deneddylation (GO:0000338)3.82046597
25respiratory electron transport chain (GO:0022904)3.79768542
26L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.76052424
27protein localization to mitochondrion (GO:0070585)3.75287154
28electron transport chain (GO:0022900)3.71839657
29negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.67955940
30negative regulation of ligase activity (GO:0051352)3.67955940
31positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.67000762
32DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.62209288
33regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.55761415
34maturation of 5.8S rRNA (GO:0000460)3.54937361
35protein K11-linked deubiquitination (GO:0035871)3.53280622
36intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.51605480
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.51605480
38signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.49546919
39signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.49546919
40signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.49546919
41response to redox state (GO:0051775)3.48142100
42regulation of mitotic spindle checkpoint (GO:1903504)3.47157347
43regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.47157347
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.46511041
45protein-cofactor linkage (GO:0018065)3.46331527
46anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.46328880
47transcription elongation from RNA polymerase III promoter (GO:0006385)3.44396237
48termination of RNA polymerase III transcription (GO:0006386)3.44396237
49establishment of integrated proviral latency (GO:0075713)3.40018101
50cytochrome complex assembly (GO:0017004)3.38823185
51signal transduction involved in DNA damage checkpoint (GO:0072422)3.37441707
52signal transduction involved in DNA integrity checkpoint (GO:0072401)3.37441707
53long-chain fatty acid biosynthetic process (GO:0042759)3.35517958
54water-soluble vitamin biosynthetic process (GO:0042364)3.35076344
55signal transduction involved in cell cycle checkpoint (GO:0072395)3.33458776
56tryptophan catabolic process (GO:0006569)3.32670420
57indole-containing compound catabolic process (GO:0042436)3.32670420
58indolalkylamine catabolic process (GO:0046218)3.32670420
59replication fork processing (GO:0031297)3.32360609
60pseudouridine synthesis (GO:0001522)3.31509948
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.31065308
62regulation of cellular amine metabolic process (GO:0033238)3.30593349
63antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.27925952
64indolalkylamine metabolic process (GO:0006586)3.27715671
65transcription elongation from RNA polymerase I promoter (GO:0006362)3.24776454
66RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.23782844
67tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.23782844
68exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.22997466
69kynurenine metabolic process (GO:0070189)3.21423791
70RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.15371341
71DNA deamination (GO:0045006)3.15348067
72fatty acid elongation (GO:0030497)3.13853579
73establishment of viral latency (GO:0019043)3.12729449
74preassembly of GPI anchor in ER membrane (GO:0016254)3.12696367
75regulation of nuclear cell cycle DNA replication (GO:0033262)3.09105891
76positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.08087744
77intracellular protein transmembrane import (GO:0044743)3.07231261
78mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.06608778
79mitochondrial respiratory chain complex I assembly (GO:0032981)3.06608778
80NADH dehydrogenase complex assembly (GO:0010257)3.06608778
81detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.05829505
82ribosomal large subunit biogenesis (GO:0042273)3.05821472
83DNA double-strand break processing (GO:0000729)3.05206413
84negative regulation of transcription regulatory region DNA binding (GO:2000678)3.04077825
85cellular ketone body metabolic process (GO:0046950)3.03988013
86negative regulation of DNA-dependent DNA replication (GO:2000104)3.03690288
87L-methionine salvage (GO:0071267)3.03550351
88L-methionine biosynthetic process (GO:0071265)3.03550351
89amino acid salvage (GO:0043102)3.03550351
90GTP biosynthetic process (GO:0006183)3.03414278
91termination of RNA polymerase I transcription (GO:0006363)3.02756651
92epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01400213
93positive regulation of ligase activity (GO:0051351)3.01092844
94neural tube formation (GO:0001841)3.00922235
95recombinational repair (GO:0000725)3.00421406
96double-strand break repair via homologous recombination (GO:0000724)3.00161097
97positive regulation of viral transcription (GO:0050434)2.97561296
98transcription-coupled nucleotide-excision repair (GO:0006283)2.95896197
99DNA damage response, detection of DNA damage (GO:0042769)2.95183796
100kidney morphogenesis (GO:0060993)2.95110658
101transcription elongation from RNA polymerase II promoter (GO:0006368)2.93765366
102transcription from RNA polymerase I promoter (GO:0006360)2.93520172
103centriole replication (GO:0007099)2.91207734
104tryptophan metabolic process (GO:0006568)2.89833125
105microtubule polymerization or depolymerization (GO:0031109)2.86723789
106rRNA catabolic process (GO:0016075)2.83301302
107somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.82340848
108isotype switching (GO:0045190)2.82340848
109somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.82340848
110S-adenosylmethionine metabolic process (GO:0046500)2.81220442
111ketone body metabolic process (GO:1902224)2.80583552
112protein prenylation (GO:0018342)2.80433270
113prenylation (GO:0097354)2.80433270
114cholesterol biosynthetic process (GO:0006695)2.79308290
115sulfation (GO:0051923)2.77798104
116DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.77255597
117protein complex biogenesis (GO:0070271)2.76789921
118dopamine transport (GO:0015872)2.75985628
119sterol biosynthetic process (GO:0016126)2.75718367
120reciprocal meiotic recombination (GO:0007131)2.74863988
121reciprocal DNA recombination (GO:0035825)2.74863988
122regulation of dopamine metabolic process (GO:0042053)2.74819717
123regulation of catecholamine metabolic process (GO:0042069)2.74819717
124positive regulation of cell cycle arrest (GO:0071158)2.74687863
125ribosome assembly (GO:0042255)2.73908735
126quinone metabolic process (GO:1901661)2.73111707
127regulation of ubiquitin-protein transferase activity (GO:0051438)2.71611402
128positive regulation of prostaglandin secretion (GO:0032308)2.69216211
129nonmotile primary cilium assembly (GO:0035058)2.68624795
130somatic diversification of immune receptors via somatic mutation (GO:0002566)2.68542943
131somatic hypermutation of immunoglobulin genes (GO:0016446)2.68542943
132antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.68430287
133rRNA modification (GO:0000154)2.68212514
134signal peptide processing (GO:0006465)2.67923492
135regulation of ligase activity (GO:0051340)2.67392918
136platelet dense granule organization (GO:0060155)2.67361045
137ubiquinone biosynthetic process (GO:0006744)2.66732042
138CENP-A containing nucleosome assembly (GO:0034080)2.66267755
139ribonucleoprotein complex biogenesis (GO:0022613)2.65379748
140cellular component biogenesis (GO:0044085)2.65285561
141serotonin receptor signaling pathway (GO:0007210)2.65146258
142transcription initiation from RNA polymerase I promoter (GO:0006361)2.65042633
143isoprenoid biosynthetic process (GO:0008299)2.63364090
144methionine biosynthetic process (GO:0009086)2.62780614
145cilium morphogenesis (GO:0060271)2.61348051
146respiratory chain complex IV assembly (GO:0008535)2.61234800
147mitochondrial respiratory chain complex assembly (GO:0033108)2.60975465
148deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.60824720
149photoreceptor cell maintenance (GO:0045494)2.59441069
150neurotransmitter uptake (GO:0001504)2.58652238
151mitochondrial transport (GO:0006839)2.58195758
152UTP biosynthetic process (GO:0006228)2.57994704
153negative regulation of translation, ncRNA-mediated (GO:0040033)2.56953124
154regulation of translation, ncRNA-mediated (GO:0045974)2.56953124
155negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.56953124
156protein polyglutamylation (GO:0018095)2.56046235
157head development (GO:0060322)2.55902277
158ubiquinone metabolic process (GO:0006743)2.55709390
159* tRNA processing (GO:0008033)2.54884437
160detection of light stimulus involved in sensory perception (GO:0050962)2.52853996
161detection of light stimulus involved in visual perception (GO:0050908)2.52853996
162negative regulation of telomere maintenance (GO:0032205)2.52441825
163meiotic chromosome segregation (GO:0045132)2.52074623
164maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.51393509
165microtubule anchoring (GO:0034453)2.49882228
166oxidative demethylation (GO:0070989)2.49711362
167negative regulation of mast cell activation (GO:0033004)2.49157426
168synapsis (GO:0007129)2.48365943
169regulation of centriole replication (GO:0046599)2.46510451
170regulation of hippo signaling (GO:0035330)2.45806622
171GPI anchor metabolic process (GO:0006505)2.45667967
172monoubiquitinated protein deubiquitination (GO:0035520)2.38329986
173regulation of telomere maintenance (GO:0032204)2.37407477
174positive regulation of fatty acid transport (GO:2000193)2.37341035
175DNA demethylation (GO:0080111)2.36816674
176protein localization to cilium (GO:0061512)2.36146768
177postreplication repair (GO:0006301)2.34873890
178regulation of mesoderm development (GO:2000380)2.34439666
179reflex (GO:0060004)2.33355260
180translesion synthesis (GO:0019985)2.33052931
181indole-containing compound metabolic process (GO:0042430)2.30837498
182UMP metabolic process (GO:0046049)2.30549145
183UMP biosynthetic process (GO:0006222)2.30549145

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.38212124
2ZNF274_21170338_ChIP-Seq_K562_Hela4.03505881
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.83965930
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.77942969
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.74396359
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.53356849
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.40594912
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.22478135
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.18246508
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.16716516
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.07975210
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.92926459
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.88058283
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.86566251
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.77561775
16TAF15_26573619_Chip-Seq_HEK293_Human2.57784263
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.39169396
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37912781
19IGF1R_20145208_ChIP-Seq_DFB_Human2.31870105
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29254773
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.27620014
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.18067117
23ELK1_19687146_ChIP-ChIP_HELA_Human2.14170713
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11178416
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.08149631
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07211221
27VDR_23849224_ChIP-Seq_CD4+_Human2.04881203
28FUS_26573619_Chip-Seq_HEK293_Human2.03986759
29IRF1_19129219_ChIP-ChIP_H3396_Human1.97782906
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.96710862
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.93836129
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93630869
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.93372879
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89459132
35GBX2_23144817_ChIP-Seq_PC3_Human1.87189793
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79209902
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.78943840
38DCP1A_22483619_ChIP-Seq_HELA_Human1.77578572
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71910509
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.71063478
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69333375
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.68865617
43FOXP3_21729870_ChIP-Seq_TREG_Human1.67322254
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66798690
45EWS_26573619_Chip-Seq_HEK293_Human1.65019938
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.60592336
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58991137
48* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58492726
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57674864
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55666764
51BCAT_22108803_ChIP-Seq_LS180_Human1.55389213
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54278472
53CBP_20019798_ChIP-Seq_JUKART_Human1.54278472
54TP53_22573176_ChIP-Seq_HFKS_Human1.53917970
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.53743445
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.51838093
57XRN2_22483619_ChIP-Seq_HELA_Human1.50575968
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49057723
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46903390
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.46229613
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42738713
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42295569
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41694212
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.40467402
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40447218
66STAT3_23295773_ChIP-Seq_U87_Human1.39385627
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38680644
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37157108
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36159902
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35053532
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34842568
72NELFA_20434984_ChIP-Seq_ESCs_Mouse1.34235904
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32759444
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32462878
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31945736
76NANOG_19829295_ChIP-Seq_ESCs_Human1.30956346
77SOX2_19829295_ChIP-Seq_ESCs_Human1.30956346
78KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29979888
79KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29979888
80KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29979888
81EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.28803273
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.28318800
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.27177355
84P300_19829295_ChIP-Seq_ESCs_Human1.26819565
85TCF4_23295773_ChIP-Seq_U87_Human1.26363912
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25887800
87SMAD4_21799915_ChIP-Seq_A2780_Human1.24039187
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.23274238
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23274238
90TCF4_22108803_ChIP-Seq_LS180_Human1.22763055
91VDR_22108803_ChIP-Seq_LS180_Human1.22101823
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19230958
93ELK1_22589737_ChIP-Seq_MCF10A_Human1.18791412
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18737448
95AR_25329375_ChIP-Seq_VCAP_Human1.18090711
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17014930
97PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16846363
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16794269
99FLI1_21867929_ChIP-Seq_TH2_Mouse1.15960321
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.14893059
101RUNX2_22187159_ChIP-Seq_PCA_Human1.14653343
102PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14545279
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.14497975
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13737664
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13737664
106MYC_18940864_ChIP-ChIP_HL60_Human1.12812559
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12750862
108ER_23166858_ChIP-Seq_MCF-7_Human1.11589422
109TTF2_22483619_ChIP-Seq_HELA_Human1.09555450
110AR_20517297_ChIP-Seq_VCAP_Human1.09489259
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09288464
112FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08544153
113BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08406246
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08001851
115OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07107137
116PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07013153
117SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06757058
118GABP_19822575_ChIP-Seq_HepG2_Human1.06479735
119HOXB7_26014856_ChIP-Seq_BT474_Human1.06066748
120ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05633570
121IRF8_21731497_ChIP-ChIP_J774_Mouse1.05489470
122CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05444153
123NANOG_18555785_Chip-Seq_ESCs_Mouse1.05096417
124NCOR_22424771_ChIP-Seq_293T_Human1.04968482
125IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04958714
126P53_22387025_ChIP-Seq_ESCs_Mouse1.04331822
127SMAD4_21741376_ChIP-Seq_EPCs_Human1.03510478
128NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.01270940
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00977660
130GATA3_21878914_ChIP-Seq_MCF-7_Human0.99836219
131CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99514010
132PRDM14_20953172_ChIP-Seq_ESCs_Human0.97665189
133SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97465359
134AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97318614
135SOX17_20123909_ChIP-Seq_XEN_Mouse0.97052259
136TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96989696
137GATA3_26560356_Chip-Seq_TH2_Human0.96199945
138NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95993602
139NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94862268
140E2F7_22180533_ChIP-Seq_HELA_Human0.94619018
141JUN_21703547_ChIP-Seq_K562_Human0.94518182
142MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93706089
143NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92679277
144FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91436414
145CBX2_27304074_Chip-Seq_ESCs_Mouse0.90206495
146EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89085814
147* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87686125
148NFE2_27457419_Chip-Seq_LIVER_Mouse0.87440674
149SOX2_16153702_ChIP-ChIP_HESCs_Human0.86555194
150RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84843551
151STAT3_18555785_Chip-Seq_ESCs_Mouse0.83868502
152CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83215343
153EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.83071744
154SUZ12_18555785_Chip-Seq_ESCs_Mouse0.82272900
155GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81861391
156RUNX1_27457419_Chip-Seq_LIVER_Mouse0.81638671

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.56348859
2MP0003136_yellow_coat_color4.02531560
3MP0001529_abnormal_vocalization3.59733486
4MP0003195_calcinosis3.26842841
5MP0001905_abnormal_dopamine_level3.05537490
6MP0002102_abnormal_ear_morphology3.04525868
7MP0006292_abnormal_olfactory_placode3.02867777
8MP0002163_abnormal_gland_morphology2.96971050
9MP0005171_absent_coat_pigmentation2.69490592
10MP0009379_abnormal_foot_pigmentation2.68567048
11MP0000372_irregular_coat_pigmentation2.66759769
12MP0003718_maternal_effect2.57243161
13MP0005409_darkened_coat_color2.47003344
14MP0006072_abnormal_retinal_apoptosis2.38641957
15MP0000566_synostosis2.31670921
16MP0003787_abnormal_imprinting2.28437006
17MP0003806_abnormal_nucleotide_metabolis2.21132090
18MP0008872_abnormal_physiological_respon2.02826706
19MP0003646_muscle_fatigue1.98189449
20MP0000427_abnormal_hair_cycle1.93783394
21MP0002837_dystrophic_cardiac_calcinosis1.92426862
22MP0002736_abnormal_nociception_after1.92222345
23MP0002272_abnormal_nervous_system1.90652196
24MP0000920_abnormal_myelination1.82890336
25MP0005379_endocrine/exocrine_gland_phen1.80801978
26MP0000569_abnormal_digit_pigmentation1.80417553
27MP0008875_abnormal_xenobiotic_pharmacok1.76159123
28MP0008058_abnormal_DNA_repair1.69340298
29MP0004043_abnormal_pH_regulation1.62280726
30MP0003693_abnormal_embryo_hatching1.60921584
31MP0001968_abnormal_touch/_nociception1.59386919
32MP0010030_abnormal_orbit_morphology1.58880527
33MP0006276_abnormal_autonomic_nervous1.58458059
34MP0005084_abnormal_gallbladder_morpholo1.57548597
35MP0004957_abnormal_blastocyst_morpholog1.56977319
36MP0004142_abnormal_muscle_tone1.54966361
37MP0005645_abnormal_hypothalamus_physiol1.52939071
38MP0000778_abnormal_nervous_system1.52748343
39MP0008932_abnormal_embryonic_tissue1.51080825
40MP0002572_abnormal_emotion/affect_behav1.45741383
41MP0002064_seizures1.45199694
42MP0004147_increased_porphyrin_level1.43647022
43MP0008260_abnormal_autophagy1.43123740
44MP0001440_abnormal_grooming_behavior1.41236041
45MP0001486_abnormal_startle_reflex1.40861441
46MP0005646_abnormal_pituitary_gland1.38651796
47MP0001188_hyperpigmentation1.38003258
48MP0003011_delayed_dark_adaptation1.34878636
49MP0002234_abnormal_pharynx_morphology1.34581174
50MP0004885_abnormal_endolymph1.34552927
51MP0000631_abnormal_neuroendocrine_gland1.34100342
52MP0009745_abnormal_behavioral_response1.32559373
53MP0003632_abnormal_nervous_system1.28986401
54MP0001984_abnormal_olfaction1.28517607
55MP0009046_muscle_twitch1.27430918
56MP0008057_abnormal_DNA_replication1.26003524
57MP0001542_abnormal_bone_strength1.24648094
58MP0005075_abnormal_melanosome_morpholog1.23824365
59MP0008995_early_reproductive_senescence1.23733120
60MP0001986_abnormal_taste_sensitivity1.23103020
61MP0010094_abnormal_chromosome_stability1.22773664
62MP0002938_white_spotting1.22275901
63MP0003690_abnormal_glial_cell1.22202240
64MP0002928_abnormal_bile_duct1.19060793
65MP0005389_reproductive_system_phenotype1.17738243
66MP0002735_abnormal_chemical_nociception1.17428110
67MP0001293_anophthalmia1.17186091
68MP0003123_paternal_imprinting1.17156270
69MP0003786_premature_aging1.13828538
70MP0005551_abnormal_eye_electrophysiolog1.13607871
71MP0004270_analgesia1.12339661
72MP0002160_abnormal_reproductive_system1.11438577
73MP0003329_amyloid_beta_deposits1.11172101
74MP0002067_abnormal_sensory_capabilities1.10447558
75MP0003635_abnormal_synaptic_transmissio1.09773790
76MP0002638_abnormal_pupillary_reflex1.09426679
77MP0002277_abnormal_respiratory_mucosa1.08977813
78MP0001727_abnormal_embryo_implantation1.08637695
79MP0003121_genomic_imprinting1.07527686
80MP0005451_abnormal_body_composition1.06761696
81MP0003938_abnormal_ear_development1.06758905
82MP0002138_abnormal_hepatobiliary_system1.05870588
83MP0002254_reproductive_system_inflammat1.05659340
84MP0001963_abnormal_hearing_physiology1.05173665
85MP0001485_abnormal_pinna_reflex1.04940452
86MP0003634_abnormal_glial_cell1.04720915
87MP0009697_abnormal_copulation1.03242432
88MP0009333_abnormal_splenocyte_physiolog1.02630392
89MP0001501_abnormal_sleep_pattern1.02204958
90MP0001919_abnormal_reproductive_system1.01807142
91MP0002876_abnormal_thyroid_physiology0.98810692
92MP0003252_abnormal_bile_duct0.98776815
93MP0002229_neurodegeneration0.98307154
94MP0001970_abnormal_pain_threshold0.97694108
95MP0008877_abnormal_DNA_methylation0.97383490
96MP0004133_heterotaxia0.97098802
97MP0002751_abnormal_autonomic_nervous0.97068118
98MP0002734_abnormal_mechanical_nocicepti0.96932741
99MP0004381_abnormal_hair_follicle0.96783634
100MP0000026_abnormal_inner_ear0.96253853
101MP0003122_maternal_imprinting0.96179751
102MP0005174_abnormal_tail_pigmentation0.95314427
103MP0004924_abnormal_behavior0.95300866
104MP0005386_behavior/neurological_phenoty0.95300866
105MP0001929_abnormal_gametogenesis0.95119101
106MP0005423_abnormal_somatic_nervous0.93649648
107MP0006082_CNS_inflammation0.93250771
108MP0003890_abnormal_embryonic-extraembry0.92206671
109MP0001835_abnormal_antigen_presentation0.92173449
110MP0004215_abnormal_myocardial_fiber0.91424930
111MP0000015_abnormal_ear_pigmentation0.91228761
112MP0003315_abnormal_perineum_morphology0.90841744
113MP0002752_abnormal_somatic_nervous0.90334124
114MP0001324_abnormal_eye_pigmentation0.89467432
115MP0002095_abnormal_skin_pigmentation0.88825828
116MP0003183_abnormal_peptide_metabolism0.88548271
117MP0002063_abnormal_learning/memory/cond0.88424627
118MP0000383_abnormal_hair_follicle0.88127726
119MP0006036_abnormal_mitochondrial_physio0.87727215
120MP0002733_abnormal_thermal_nociception0.87159690
121MP0003937_abnormal_limbs/digits/tail_de0.86833768
122MP0000647_abnormal_sebaceous_gland0.85889236
123MP0003567_abnormal_fetal_cardiomyocyte0.85623469
124MP0002210_abnormal_sex_determination0.84830197
125MP0005391_vision/eye_phenotype0.84574006
126MP0002557_abnormal_social/conspecific_i0.84395319
127MP0004145_abnormal_muscle_electrophysio0.83254808
128MP0006035_abnormal_mitochondrial_morpho0.82396470
129MP0005253_abnormal_eye_physiology0.82377640
130MP0000538_abnormal_urinary_bladder0.82156476
131MP0001873_stomach_inflammation0.82044174
132MP0003698_abnormal_male_reproductive0.81758974
133MP0008961_abnormal_basal_metabolism0.81554180
134MP0002090_abnormal_vision0.81265036
135MP0000049_abnormal_middle_ear0.80060667
136MP0010386_abnormal_urinary_bladder0.79957176
137MP0003077_abnormal_cell_cycle0.78832358
138MP0005671_abnormal_response_to0.78391087
139MP0005367_renal/urinary_system_phenotyp0.78105563
140MP0000516_abnormal_urinary_system0.78105563
141MP0000230_abnormal_systemic_arterial0.77853623
142MP0001119_abnormal_female_reproductive0.77537568
143MP0003186_abnormal_redox_activity0.77373884
144MP0000653_abnormal_sex_gland0.76785944
145MP0008775_abnormal_heart_ventricle0.76592392
146MP0003950_abnormal_plasma_membrane0.75949386
147MP0008789_abnormal_olfactory_epithelium0.75406590
148MP0002882_abnormal_neuron_morphology0.75327336
149MP0005410_abnormal_fertilization0.73674100
150MP0003119_abnormal_digestive_system0.73190972
151MP0001145_abnormal_male_reproductive0.72576640
152MP0002132_abnormal_respiratory_system0.72532491
153MP0005195_abnormal_posterior_eye0.72293476
154MP0002653_abnormal_ependyma_morphology0.72060602
155MP0002184_abnormal_innervation0.71291599
156MP0004742_abnormal_vestibular_system0.67058333

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.85396455
2Pancreatic cysts (HP:0001737)4.39456715
3Pancreatic fibrosis (HP:0100732)4.06292489
4Abnormal mitochondria in muscle tissue (HP:0008316)4.00392730
5Mitochondrial inheritance (HP:0001427)3.93915417
6Molar tooth sign on MRI (HP:0002419)3.87003190
7Progressive macrocephaly (HP:0004481)3.86399264
8Acute encephalopathy (HP:0006846)3.69300673
9Abnormality of glycolysis (HP:0004366)3.68184040
10Increased serum pyruvate (HP:0003542)3.68184040
11True hermaphroditism (HP:0010459)3.51113170
12Increased CSF lactate (HP:0002490)3.48767458
13Hepatocellular necrosis (HP:0001404)3.45561943
14Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.37071369
15Congenital stationary night blindness (HP:0007642)3.36796895
163-Methylglutaconic aciduria (HP:0003535)3.20233139
17Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.19585258
18Nephronophthisis (HP:0000090)3.17410283
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.16699180
20Abnormality of the renal cortex (HP:0011035)3.14687434
21Parakeratosis (HP:0001036)3.13676266
22Chronic hepatic failure (HP:0100626)3.11208816
23Carpal bone hypoplasia (HP:0001498)3.09540637
24Sensory axonal neuropathy (HP:0003390)3.06020069
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.90954517
26Decreased activity of mitochondrial respiratory chain (HP:0008972)2.90954517
27Increased hepatocellular lipid droplets (HP:0006565)2.90647161
28Renal Fanconi syndrome (HP:0001994)2.90544078
29Abnormality of the renal medulla (HP:0100957)2.89675220
30Leukodystrophy (HP:0002415)2.88203060
31Birth length less than 3rd percentile (HP:0003561)2.87963661
32Abolished electroretinogram (ERG) (HP:0000550)2.80441008
33Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.74737308
34Abnormality of the pons (HP:0007361)2.71743330
35Abnormal drinking behavior (HP:0030082)2.71129956
36Polydipsia (HP:0001959)2.71129956
37Irregular epiphyses (HP:0010582)2.68976200
38Hypoplasia of the pons (HP:0012110)2.68392775
39Stenosis of the external auditory canal (HP:0000402)2.67401642
40Bile duct proliferation (HP:0001408)2.66808934
41Abnormal biliary tract physiology (HP:0012439)2.66808934
42Tubular atrophy (HP:0000092)2.62696356
43Attenuation of retinal blood vessels (HP:0007843)2.60882360
44Optic disc pallor (HP:0000543)2.60255634
45Hypoplastic pelvis (HP:0008839)2.52886764
46Cystic liver disease (HP:0006706)2.51956089
47Hepatic necrosis (HP:0002605)2.49983717
48Cerebral edema (HP:0002181)2.49371365
49Increased serum lactate (HP:0002151)2.46408462
50Intestinal atresia (HP:0011100)2.46304906
51Abnormality of alanine metabolism (HP:0010916)2.42885431
52Hyperalaninemia (HP:0003348)2.42885431
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42885431
54Breast hypoplasia (HP:0003187)2.42494643
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.40035394
56Hyperventilation (HP:0002883)2.39111156
57Renal cortical cysts (HP:0000803)2.38997280
58Abnormality of the axillary hair (HP:0100134)2.37728677
59Abnormality of secondary sexual hair (HP:0009888)2.37728677
60Exercise intolerance (HP:0003546)2.35042259
61Microvesicular hepatic steatosis (HP:0001414)2.34160818
62Meckel diverticulum (HP:0002245)2.34074099
63Abnormality of the ileum (HP:0001549)2.30422849
64Abnormal rod and cone electroretinograms (HP:0008323)2.28200553
65Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28033521
66Rectovaginal fistula (HP:0000143)2.27626128
67Rectal fistula (HP:0100590)2.27626128
68Adrenal hypoplasia (HP:0000835)2.26291142
69Type II lissencephaly (HP:0007260)2.25998355
70Abnormality of chromosome stability (HP:0003220)2.25872021
71Respiratory failure (HP:0002878)2.25368867
72Abnormal lung lobation (HP:0002101)2.24107075
73Postnatal microcephaly (HP:0005484)2.23765974
74Cerebral hypomyelination (HP:0006808)2.21643234
75Chromsome breakage (HP:0040012)2.20677552
76Lipid accumulation in hepatocytes (HP:0006561)2.19591809
77Aplasia/Hypoplasia of the tibia (HP:0005772)2.18691490
78Medial flaring of the eyebrow (HP:0010747)2.18565377
79Abnormality of the labia minora (HP:0012880)2.17930622
80Anencephaly (HP:0002323)2.16305228
81Respiratory difficulties (HP:0002880)2.16066921
82Abnormality of cells of the erythroid lineage (HP:0012130)2.15435326
83X-linked dominant inheritance (HP:0001423)2.13898394
84Protruding tongue (HP:0010808)2.13785874
85Gaze-evoked nystagmus (HP:0000640)2.13474146
86Polyuria (HP:0000103)2.13106711
87Progressive inability to walk (HP:0002505)2.09312136
88Broad-based gait (HP:0002136)2.09054758
89Clubbing of toes (HP:0100760)2.07737820
90Aplasia/Hypoplasia of the spleen (HP:0010451)2.07225647
91Aplasia/Hypoplasia of the tongue (HP:0010295)2.06951890
92Abnormality of the renal collecting system (HP:0004742)2.05661489
93Duplicated collecting system (HP:0000081)2.04432222
94Hyperglycinemia (HP:0002154)2.04279482
95Colon cancer (HP:0003003)2.04140566
96Focal motor seizures (HP:0011153)2.03256604
97Methylmalonic acidemia (HP:0002912)2.02063649
98Type I transferrin isoform profile (HP:0003642)2.01517076
99Nephrogenic diabetes insipidus (HP:0009806)2.00489520
100Abnormal hair whorl (HP:0010721)2.00378747
101Sclerocornea (HP:0000647)2.00000462
102Congenital hepatic fibrosis (HP:0002612)1.98766159
103Congenital ichthyosiform erythroderma (HP:0007431)1.98653659
104Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98099364
105Supernumerary spleens (HP:0009799)1.97394430
106Asplenia (HP:0001746)1.96290848
107Concave nail (HP:0001598)1.95357471
108Anomalous pulmonary venous return (HP:0010772)1.94355292
109Aplasia/Hypoplasia involving the musculature (HP:0001460)1.94090520
110Inability to walk (HP:0002540)1.93914328
111Sloping forehead (HP:0000340)1.92954695
112Cerebellar dysplasia (HP:0007033)1.91805760
113Aplasia involving forearm bones (HP:0009822)1.91071880
114Absent forearm bone (HP:0003953)1.91071880
115Pendular nystagmus (HP:0012043)1.89933078
116Degeneration of the lateral corticospinal tracts (HP:0002314)1.89527783
117Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.89527783
118Dandy-Walker malformation (HP:0001305)1.88694959
119Patchy hypopigmentation of hair (HP:0011365)1.87778843
120Optic nerve hypoplasia (HP:0000609)1.86995405
121Genetic anticipation (HP:0003743)1.86975502
122Congenital, generalized hypertrichosis (HP:0004540)1.86534639
123Septo-optic dysplasia (HP:0100842)1.86411325
124Large for gestational age (HP:0001520)1.86116503
125Genital tract atresia (HP:0001827)1.86097968
126Lissencephaly (HP:0001339)1.85491434
127Furrowed tongue (HP:0000221)1.85304427
128Lactic acidosis (HP:0003128)1.84541777
129Diastasis recti (HP:0001540)1.83393836
130Aplasia/hypoplasia of the uterus (HP:0008684)1.82802569
131Decreased central vision (HP:0007663)1.82553208
132Progressive external ophthalmoplegia (HP:0000590)1.82432493
133Exertional dyspnea (HP:0002875)1.81792984
134Absent radius (HP:0003974)1.81308418
135Vaginal atresia (HP:0000148)1.80373466
136Thyroiditis (HP:0100646)1.80160241
137Abnormality of homocysteine metabolism (HP:0010919)1.79593630
138Homocystinuria (HP:0002156)1.79593630
139Chromosomal breakage induced by crosslinking agents (HP:0003221)1.77813951
140Abnormality of the preputium (HP:0100587)1.77223862
141Abnormal number of erythroid precursors (HP:0012131)1.76917485
142Vaginal fistula (HP:0004320)1.76169690
143Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75886138
144Male pseudohermaphroditism (HP:0000037)1.75866311
145Absent thumb (HP:0009777)1.75793929
146Bony spicule pigmentary retinopathy (HP:0007737)1.75560933
147Small epiphyses (HP:0010585)1.75257490
148Oligodactyly (hands) (HP:0001180)1.74810164
149Split foot (HP:0001839)1.74786660
150Progressive cerebellar ataxia (HP:0002073)1.74715880
151Heterochromia iridis (HP:0001100)1.74270782
152Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73305901
153Absent epiphyses (HP:0010577)1.73305901
154Macrocytic anemia (HP:0001972)1.73259699
155Abnormality of the pulmonary veins (HP:0011718)1.73043545
156Epileptic encephalopathy (HP:0200134)1.72797698
157Ectopic kidney (HP:0000086)1.72408348
158Patellar aplasia (HP:0006443)1.71985154
159Delusions (HP:0000746)1.71454601
160Triphalangeal thumb (HP:0001199)1.70961602
161Hypoplastic left heart (HP:0004383)1.70848194
162Abnormality of the septum pellucidum (HP:0007375)1.69414212
163Poor head control (HP:0002421)1.68806348
164Aganglionic megacolon (HP:0002251)1.68125062
165Retinal dysplasia (HP:0007973)1.68080193
166Gait imbalance (HP:0002141)1.66748675
167Fibular aplasia (HP:0002990)1.65979014
168Absent septum pellucidum (HP:0001331)1.65968276
169Sparse eyelashes (HP:0000653)1.65653281
170Emotional lability (HP:0000712)1.64895351
171Aplasia/Hypoplasia of the sacrum (HP:0008517)1.63752623
172Conical tooth (HP:0000698)1.63057068
173CNS demyelination (HP:0007305)1.62632841
174Congenital primary aphakia (HP:0007707)1.62620842
175White forelock (HP:0002211)1.61459819
176Hypothermia (HP:0002045)1.60091771
177Abnormality of midbrain morphology (HP:0002418)1.57911381

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.43251040
2BMPR1B3.18814879
3MKNK13.06840955
4CASK3.00474674
5MUSK2.80660831
6BUB12.79508181
7EIF2AK32.77508352
8EIF2AK12.54829667
9MAPKAPK52.48611871
10TXK2.48203122
11NUAK12.29206235
12TRIM282.28284798
13PBK2.27039227
14FGR2.25202502
15SRPK12.21600850
16NME12.20383331
17TAOK32.17826097
18MAP4K21.98287856
19INSRR1.90197198
20STK161.89953105
21GRK51.88833405
22WNK41.86831605
23WEE11.75046388
24TLK11.74261667
25YES11.73998334
26MST41.69823288
27PNCK1.66210236
28STK391.59872380
29NEK61.58448064
30MATK1.55959129
31TNIK1.55897006
32PLK41.54597245
33IRAK31.52198994
34MAP3K121.49471224
35IRAK41.48273343
36BCR1.45256372
37ADRBK21.44556957
38MAP3K41.44377936
39AKT31.41651223
40DYRK21.38035782
41GRK71.36236459
42CSNK1G31.31432173
43OXSR11.29668657
44VRK11.28001657
45TGFBR11.27621382
46TSSK61.22614775
47PLK21.19878891
48NME21.18420869
49EIF2AK21.17580636
50SIK21.17063043
51PIM21.17029111
52ARAF1.14131492
53MKNK21.11262141
54PINK11.09203542
55RPS6KA51.07508494
56CAMKK20.96960125
57PLK30.95588476
58PAK30.94203730
59RIPK40.94078323
60CSNK1G10.92949246
61MAPK130.90816046
62ERBB30.89917825
63BRAF0.86597971
64ACVR1B0.81504377
65GRK60.80952778
66CSNK1A1L0.80700216
67TEC0.80617058
68FGFR20.78613243
69ABL20.76911386
70ATR0.75459699
71CSNK1G20.75175889
72BCKDK0.74157965
73CSK0.73786045
74IRAK10.73585483
75PKN10.72955529
76CDK30.71663621
77PIK3CA0.70225713
78IRAK20.68328661
79CAMK2B0.65565009
80BMPR20.65053659
81AURKA0.63851501
82CSF1R0.63457583
83TIE10.62845321
84DAPK20.62501966
85STK30.61724167
86WNK30.60851097
87UHMK10.60476029
88PRPF4B0.59811233
89PTK2B0.59543811
90CAMK2A0.59542686
91LIMK10.59057617
92PRKCQ0.58308652
93CSNK2A10.58291622
94IKBKB0.56941499
95MET0.56817118
96PLK10.56418783
97CHEK20.55410304
98EPHA40.55032806
99PAK10.54976406
100PDK20.53931033
101BRD40.53773615
102MOS0.53404182
103CDK80.52730488
104FES0.51747844
105KIT0.51301774
106RPS6KA40.51055418
107ZAK0.50316328
108CSNK2A20.50003306
109ATM0.49994276
110FLT30.49203728
111CAMK2D0.48771745
112PASK0.48446059
113LYN0.47335301
114ADRBK10.46736657
115MAPK150.46687723
116CDC70.44672340
117ROCK20.44191848
118PRKCH0.43548389
119BRSK20.43488663
120CDK190.43024161
121MARK10.42763249
122NLK0.42068889
123TYK20.41670429
124GRK10.40576195
125PRKCG0.39880333
126STK38L0.39653243
127PRKCE0.39001747
128CSNK1A10.38929266
129CDK140.38114119
130MAP2K60.37225204
131PHKG20.36674969
132PHKG10.36674969
133MYLK0.35800619
134ITK0.34734231
135MAP2K70.34563956
136SGK20.34432026
137DYRK30.33279815
138OBSCN0.33195256
139EPHB10.33150436
140DYRK1A0.32963013
141NEK20.32881191
142PRKACA0.32671840
143SIK30.31293270
144TTK0.30942003
145IKBKE0.30573754
146STK110.29406519

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.86970488
2Oxidative phosphorylation_Homo sapiens_hsa001904.26831151
3Parkinsons disease_Homo sapiens_hsa050123.40380354
4RNA polymerase_Homo sapiens_hsa030203.29180967
5Ribosome_Homo sapiens_hsa030103.16393185
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.80217466
7Huntingtons disease_Homo sapiens_hsa050162.63314593
8Alzheimers disease_Homo sapiens_hsa050102.58242536
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.54898913
10Steroid biosynthesis_Homo sapiens_hsa001002.35693620
11Selenocompound metabolism_Homo sapiens_hsa004502.24444372
12Butanoate metabolism_Homo sapiens_hsa006502.14628549
13Spliceosome_Homo sapiens_hsa030402.12688560
14Protein export_Homo sapiens_hsa030602.11522494
15Basal transcription factors_Homo sapiens_hsa030222.03170193
16Nitrogen metabolism_Homo sapiens_hsa009102.00720094
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.90771564
18Nucleotide excision repair_Homo sapiens_hsa034201.85790039
19DNA replication_Homo sapiens_hsa030301.83605424
20Mismatch repair_Homo sapiens_hsa034301.81563998
21Vitamin B6 metabolism_Homo sapiens_hsa007501.77961655
22Pyrimidine metabolism_Homo sapiens_hsa002401.74103353
23Ether lipid metabolism_Homo sapiens_hsa005651.71593135
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.68723622
25Collecting duct acid secretion_Homo sapiens_hsa049661.66213170
26RNA transport_Homo sapiens_hsa030131.65653395
27Fatty acid elongation_Homo sapiens_hsa000621.63785976
28Caffeine metabolism_Homo sapiens_hsa002321.62430026
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53420850
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51351260
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49748772
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47357036
33Homologous recombination_Homo sapiens_hsa034401.45977708
34Propanoate metabolism_Homo sapiens_hsa006401.42117822
35Tryptophan metabolism_Homo sapiens_hsa003801.37410176
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32859877
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.31553194
38Linoleic acid metabolism_Homo sapiens_hsa005911.30528766
39Base excision repair_Homo sapiens_hsa034101.30132121
40Arachidonic acid metabolism_Homo sapiens_hsa005901.26378370
41Nicotine addiction_Homo sapiens_hsa050331.20874923
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18835086
43Fanconi anemia pathway_Homo sapiens_hsa034601.18730260
44Serotonergic synapse_Homo sapiens_hsa047261.18552792
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17884004
46Purine metabolism_Homo sapiens_hsa002301.16889450
47RNA degradation_Homo sapiens_hsa030181.14936121
48Peroxisome_Homo sapiens_hsa041461.14391447
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13514116
50Sulfur relay system_Homo sapiens_hsa041221.12785091
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12264633
52Cardiac muscle contraction_Homo sapiens_hsa042601.09814810
53Primary bile acid biosynthesis_Homo sapiens_hsa001201.09174947
54Olfactory transduction_Homo sapiens_hsa047401.08770820
55Non-homologous end-joining_Homo sapiens_hsa034501.07373736
56SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07266872
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07087593
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05988163
59Chemical carcinogenesis_Homo sapiens_hsa052041.04776967
60Rheumatoid arthritis_Homo sapiens_hsa053230.99574781
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98620425
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98208939
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.97524818
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97285612
65One carbon pool by folate_Homo sapiens_hsa006700.95188872
66Long-term depression_Homo sapiens_hsa047300.94805137
67Primary immunodeficiency_Homo sapiens_hsa053400.93499683
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92326273
69Vibrio cholerae infection_Homo sapiens_hsa051100.89052081
70Retinol metabolism_Homo sapiens_hsa008300.88485724
71Glycerolipid metabolism_Homo sapiens_hsa005610.86553219
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84280225
73Phototransduction_Homo sapiens_hsa047440.82777224
74Regulation of autophagy_Homo sapiens_hsa041400.81395820
75Fat digestion and absorption_Homo sapiens_hsa049750.81215760
76Autoimmune thyroid disease_Homo sapiens_hsa053200.76205949
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74386693
78Phagosome_Homo sapiens_hsa041450.73694953
79Metabolic pathways_Homo sapiens_hsa011000.73110815
80ABC transporters_Homo sapiens_hsa020100.72109474
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71688810
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.69093528
83Glutamatergic synapse_Homo sapiens_hsa047240.65035196
84Cell cycle_Homo sapiens_hsa041100.65007514
85Epstein-Barr virus infection_Homo sapiens_hsa051690.63965633
86Allograft rejection_Homo sapiens_hsa053300.63418065
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62470734
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61013306
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58314047
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56620174
91GABAergic synapse_Homo sapiens_hsa047270.51503802
92Sphingolipid metabolism_Homo sapiens_hsa006000.49876527
93beta-Alanine metabolism_Homo sapiens_hsa004100.49495911
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48341310
95Glutathione metabolism_Homo sapiens_hsa004800.48143450
96mRNA surveillance pathway_Homo sapiens_hsa030150.45640439
97Sulfur metabolism_Homo sapiens_hsa009200.43924419
98Circadian rhythm_Homo sapiens_hsa047100.42084811
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41400505
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38984125
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37459489
102Graft-versus-host disease_Homo sapiens_hsa053320.36351378
103Ovarian steroidogenesis_Homo sapiens_hsa049130.35210917
104Tyrosine metabolism_Homo sapiens_hsa003500.34391876
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33842813
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32786343
107Histidine metabolism_Homo sapiens_hsa003400.32585458
108Fatty acid degradation_Homo sapiens_hsa000710.32327710
109p53 signaling pathway_Homo sapiens_hsa041150.32299875
110Phenylalanine metabolism_Homo sapiens_hsa003600.31706781
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31604261
112Synaptic vesicle cycle_Homo sapiens_hsa047210.31379196
113Type I diabetes mellitus_Homo sapiens_hsa049400.31262139
114Malaria_Homo sapiens_hsa051440.30874085
115Taste transduction_Homo sapiens_hsa047420.30744063
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.30739851
117Alcoholism_Homo sapiens_hsa050340.28592348
118Systemic lupus erythematosus_Homo sapiens_hsa053220.28507315
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28013670
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.27869337
121Arginine and proline metabolism_Homo sapiens_hsa003300.26539180
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25399242
123Morphine addiction_Homo sapiens_hsa050320.24667523
124African trypanosomiasis_Homo sapiens_hsa051430.24424647
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21130528
126Cocaine addiction_Homo sapiens_hsa050300.20230444
127Asthma_Homo sapiens_hsa053100.20179086
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.20100079
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19152474
130Axon guidance_Homo sapiens_hsa043600.17719974
131Oocyte meiosis_Homo sapiens_hsa041140.16180640
132Circadian entrainment_Homo sapiens_hsa047130.14778126
133Shigellosis_Homo sapiens_hsa051310.14564851
134Pentose phosphate pathway_Homo sapiens_hsa000300.12282407
135Vitamin digestion and absorption_Homo sapiens_hsa049770.11927592
136Dopaminergic synapse_Homo sapiens_hsa047280.10688725

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