U2AF1L4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)8.08979670
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.01082742
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.85431179
4ATP synthesis coupled proton transport (GO:0015986)5.85431179
5behavioral response to nicotine (GO:0035095)5.38224581
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.36763031
7mitochondrial respiratory chain complex I assembly (GO:0032981)5.08848003
8NADH dehydrogenase complex assembly (GO:0010257)5.08848003
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.08848003
10protein complex biogenesis (GO:0070271)4.90078868
11protein neddylation (GO:0045116)4.83935756
12respiratory electron transport chain (GO:0022904)4.76328657
13proteasome assembly (GO:0043248)4.73467304
14electron transport chain (GO:0022900)4.64996290
15mitochondrial respiratory chain complex assembly (GO:0033108)4.40981065
16ribosomal large subunit biogenesis (GO:0042273)4.37504721
17L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.28225239
18protein targeting to mitochondrion (GO:0006626)4.27676617
19ribosomal small subunit assembly (GO:0000028)4.20480222
20viral transcription (GO:0019083)4.11652743
21maturation of 5.8S rRNA (GO:0000460)4.10677218
22establishment of protein localization to mitochondrion (GO:0072655)3.99974059
23translational termination (GO:0006415)3.99931128
24transcription elongation from RNA polymerase III promoter (GO:0006385)3.99738310
25termination of RNA polymerase III transcription (GO:0006386)3.99738310
26DNA deamination (GO:0045006)3.95119184
27ribosomal small subunit biogenesis (GO:0042274)3.84205410
28cotranslational protein targeting to membrane (GO:0006613)3.73601451
29protein localization to mitochondrion (GO:0070585)3.72468387
30indole-containing compound catabolic process (GO:0042436)3.67643053
31indolalkylamine catabolic process (GO:0046218)3.67643053
32tryptophan catabolic process (GO:0006569)3.67643053
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.67295851
34cytidine deamination (GO:0009972)3.67152369
35cytidine metabolic process (GO:0046087)3.67152369
36cytidine catabolic process (GO:0006216)3.67152369
37L-fucose metabolic process (GO:0042354)3.65126889
38L-fucose catabolic process (GO:0042355)3.65126889
39fucose catabolic process (GO:0019317)3.65126889
40protein targeting to ER (GO:0045047)3.62929595
41protein localization to endoplasmic reticulum (GO:0070972)3.61973968
42cullin deneddylation (GO:0010388)3.60335841
437-methylguanosine mRNA capping (GO:0006370)3.56790119
44indolalkylamine metabolic process (GO:0006586)3.55906611
45negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.55454893
46regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.55201740
47RNA capping (GO:0036260)3.54427836
487-methylguanosine RNA capping (GO:0009452)3.54427836
49kynurenine metabolic process (GO:0070189)3.49159227
50respiratory chain complex IV assembly (GO:0008535)3.49153411
51water-soluble vitamin biosynthetic process (GO:0042364)3.46904622
52establishment of protein localization to endoplasmic reticulum (GO:0072599)3.45253172
53protein deneddylation (GO:0000338)3.44190985
54sulfation (GO:0051923)3.42744643
55maturation of SSU-rRNA (GO:0030490)3.36209314
56detection of light stimulus involved in visual perception (GO:0050908)3.33811641
57detection of light stimulus involved in sensory perception (GO:0050962)3.33811641
58cellular protein complex disassembly (GO:0043624)3.28012671
59regulation of cellular amino acid metabolic process (GO:0006521)3.27108743
60negative regulation of mast cell activation (GO:0033004)3.26270030
61protein polyglutamylation (GO:0018095)3.25488984
62positive regulation of defense response to virus by host (GO:0002230)3.24474049
63translational elongation (GO:0006414)3.24162506
64positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.23445247
65negative regulation of ligase activity (GO:0051352)3.23336228
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.23336228
67GTP biosynthetic process (GO:0006183)3.22307843
68pyrimidine ribonucleoside catabolic process (GO:0046133)3.20914435
69DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.19416489
70positive regulation of prostaglandin secretion (GO:0032308)3.18271536
71viral life cycle (GO:0019058)3.17645649
72amino acid salvage (GO:0043102)3.16449252
73L-methionine salvage (GO:0071267)3.16449252
74L-methionine biosynthetic process (GO:0071265)3.16449252
75quinone biosynthetic process (GO:1901663)3.15796503
76ubiquinone biosynthetic process (GO:0006744)3.15796503
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15637033
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.15086592
79regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14996624
80cellular component biogenesis (GO:0044085)3.14408435
81preassembly of GPI anchor in ER membrane (GO:0016254)3.12570693
82intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.11698620
83signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.11698620
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.11605398
85tryptophan metabolic process (GO:0006568)3.11300779
86signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.10961170
87signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.10961170
88signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.10961170
89mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.10687999
90metallo-sulfur cluster assembly (GO:0031163)3.09687004
91iron-sulfur cluster assembly (GO:0016226)3.09687004
92translation (GO:0006412)3.07909213
93positive regulation of fatty acid transport (GO:2000193)3.07299760
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06809347
95hydrogen ion transmembrane transport (GO:1902600)3.06153200
96cytochrome complex assembly (GO:0017004)3.06067415
97translational initiation (GO:0006413)3.04995035
98gamma-aminobutyric acid transport (GO:0015812)3.04146949
99platelet dense granule organization (GO:0060155)3.03830116
100establishment of protein localization to mitochondrial membrane (GO:0090151)3.03564015
101negative regulation of telomere maintenance (GO:0032205)3.02926471
102DNA ligation (GO:0006266)3.02748342
103signal transduction involved in cell cycle checkpoint (GO:0072395)3.00966688
104signal transduction involved in DNA integrity checkpoint (GO:0072401)3.00952212
105signal transduction involved in DNA damage checkpoint (GO:0072422)3.00952212
106purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.95595953
107transcription-coupled nucleotide-excision repair (GO:0006283)2.94426860
108deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.93501219
109antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.90417866
110cellular response to ATP (GO:0071318)2.89080557
111ATP biosynthetic process (GO:0006754)2.87963984
112intracellular protein transmembrane import (GO:0044743)2.87851546
113purine nucleoside triphosphate biosynthetic process (GO:0009145)2.87130529
114positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.86783463
115nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.85603730
116peptidyl-histidine modification (GO:0018202)2.85025580
117amine catabolic process (GO:0009310)2.83910142
118cellular biogenic amine catabolic process (GO:0042402)2.83910142
119mannosylation (GO:0097502)2.82496746
120oxidative phosphorylation (GO:0006119)2.81889722
121rRNA modification (GO:0000154)2.81306584
122ubiquinone metabolic process (GO:0006743)2.81254408
123guanosine-containing compound biosynthetic process (GO:1901070)2.80313374
124pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.78736033
125protein complex disassembly (GO:0043241)2.78514336
126indole-containing compound metabolic process (GO:0042430)2.78497035
127positive regulation of ligase activity (GO:0051351)2.78275910
128negative regulation of appetite (GO:0032099)2.77696361
129negative regulation of response to food (GO:0032096)2.77696361
130regulation of mitochondrial translation (GO:0070129)2.75994475
131inner mitochondrial membrane organization (GO:0007007)2.75226587
132mitochondrial transport (GO:0006839)2.72362355
133NAD biosynthetic process (GO:0009435)2.71952812
134macromolecular complex disassembly (GO:0032984)2.70418487
135proton transport (GO:0015992)2.69570681
136RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.69353888
137tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.69353888
138regulation of cellular amine metabolic process (GO:0033238)2.68869390
139axoneme assembly (GO:0035082)2.66130119
140adaptation of signaling pathway (GO:0023058)2.62951003
141negative regulation of transcription regulatory region DNA binding (GO:2000678)2.62313859
142positive regulation of icosanoid secretion (GO:0032305)2.61141692
143detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.61061403
144serotonin metabolic process (GO:0042428)2.59624818
145regulation of memory T cell differentiation (GO:0043380)2.59495174
146cAMP catabolic process (GO:0006198)2.56099615
147primary amino compound metabolic process (GO:1901160)2.55153585
148cellular response to interleukin-15 (GO:0071350)2.55048937
149mast cell activation involved in immune response (GO:0002279)2.54045318
150mast cell degranulation (GO:0043303)2.54045318
151GPI anchor metabolic process (GO:0006505)2.51610640
152tolerance induction (GO:0002507)2.49685488
153protein-cofactor linkage (GO:0018065)2.49343197
154piRNA metabolic process (GO:0034587)2.47138087
155positive regulation of calcium-mediated signaling (GO:0050850)2.47001488
156positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.46836037
157negative regulation of heart rate (GO:0010459)2.46307916
158neuronal action potential (GO:0019228)2.43356685
159regulation of germinal center formation (GO:0002634)2.40934312
160positive regulation of T-helper 1 type immune response (GO:0002827)2.39197104
161base-excision repair, AP site formation (GO:0006285)2.35383617
162cellular ketone body metabolic process (GO:0046950)2.34442730
163activated T cell proliferation (GO:0050798)2.34248082
164alanine transport (GO:0032328)2.30985210
165regulation of cilium movement (GO:0003352)2.30951047
1663-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.30637039
167purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.30637039
168adenosine metabolic process (GO:0046085)2.30424966
169positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.30411821
170interferon-gamma production (GO:0032609)2.30015035
171multicellular organism reproduction (GO:0032504)2.29873239
172mast cell activation (GO:0045576)2.29816511
173cyclic nucleotide catabolic process (GO:0009214)2.29625650
174negative regulation of membrane potential (GO:0045837)2.29437281
175dopamine transport (GO:0015872)2.28982003
176regulation of prostaglandin secretion (GO:0032306)2.28087919
177regulation of rhodopsin mediated signaling pathway (GO:0022400)2.27321571
178rhodopsin mediated signaling pathway (GO:0016056)2.26615135
179synaptic transmission, cholinergic (GO:0007271)2.25242342
180regulation of action potential (GO:0098900)2.24834885
181replication fork processing (GO:0031297)2.24762183
182positive regulation of organic acid transport (GO:0032892)2.24731630
183purinergic nucleotide receptor signaling pathway (GO:0035590)2.23595965
184cellular response to interferon-beta (GO:0035458)2.23057710
185response to interferon-beta (GO:0035456)2.22524776

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.77630437
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.46348396
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.15307689
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.13333076
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.06497582
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.87912661
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.66893972
8ZNF274_21170338_ChIP-Seq_K562_Hela3.63210472
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.57265760
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.54585627
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.27691895
12IRF8_22096565_ChIP-ChIP_GC-B_Human3.08052699
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.04211033
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.95652841
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.91050000
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.72386902
17* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.70507322
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.69175368
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.66570955
20VDR_23849224_ChIP-Seq_CD4+_Human2.62210041
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.53889810
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.52601403
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.46120814
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.42965357
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.39737858
26GBX2_23144817_ChIP-Seq_PC3_Human2.36154835
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.33775900
28DCP1A_22483619_ChIP-Seq_HELA_Human2.33265933
29FOXP3_21729870_ChIP-Seq_TREG_Human2.22293155
30YY1_21170310_ChIP-Seq_MESCs_Mouse2.20151127
31ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04264934
32XRN2_22483619_ChIP-Seq_HELA_Human2.04206498
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98141552
34IGF1R_20145208_ChIP-Seq_DFB_Human1.96811417
35TTF2_22483619_ChIP-Seq_HELA_Human1.95214994
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95209975
37* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.94301841
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89307073
39* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.88080177
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.81909326
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80934291
42GABP_19822575_ChIP-Seq_HepG2_Human1.77973907
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77958537
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.77111857
45CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.74623293
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74005386
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70215384
48* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68379550
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64290300
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.64002614
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63615753
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.63593817
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.62483730
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59575498
55ELK1_19687146_ChIP-ChIP_HELA_Human1.56559279
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54253399
57TP53_22573176_ChIP-Seq_HFKS_Human1.54245637
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53359732
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.48657181
60ER_23166858_ChIP-Seq_MCF-7_Human1.48366860
61RUNX_20019798_ChIP-Seq_JUKART_Human1.46649017
62* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44084666
63GATA3_26560356_Chip-Seq_TH2_Human1.42641414
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40869027
65BCAT_22108803_ChIP-Seq_LS180_Human1.40605114
66E2F7_22180533_ChIP-Seq_HELA_Human1.40551335
67EWS_26573619_Chip-Seq_HEK293_Human1.40307392
68CIITA_25753668_ChIP-Seq_RAJI_Human1.38947341
69P300_19829295_ChIP-Seq_ESCs_Human1.37603674
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36955514
71VDR_22108803_ChIP-Seq_LS180_Human1.35914233
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.34848040
73GATA3_21878914_ChIP-Seq_MCF-7_Human1.34489121
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34473873
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32483493
76FOXA1_25329375_ChIP-Seq_VCAP_Human1.32483493
77FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30978130
78REST_21632747_ChIP-Seq_MESCs_Mouse1.30258752
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27879434
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27687585
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26279430
82CBP_20019798_ChIP-Seq_JUKART_Human1.26279430
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26183498
84MYC_18940864_ChIP-ChIP_HL60_Human1.25482540
85NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24497126
86* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.23555133
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23345238
88NCOR_22424771_ChIP-Seq_293T_Human1.23221992
89ELK1_22589737_ChIP-Seq_MCF10A_Human1.22735254
90FUS_26573619_Chip-Seq_HEK293_Human1.22613481
91MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18068170
92NANOG_19829295_ChIP-Seq_ESCs_Human1.17347000
93SOX2_19829295_ChIP-Seq_ESCs_Human1.17347000
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.16822993
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15861955
96ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15403506
97AR_20517297_ChIP-Seq_VCAP_Human1.14813984
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14558468
99TAF2_19829295_ChIP-Seq_ESCs_Human1.13509371
100MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13023359
101TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11854960
102FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11652766
103EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10142534
104EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09939140
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09718585
106NOTCH1_21737748_ChIP-Seq_TLL_Human1.09544906
107EZH2_22144423_ChIP-Seq_EOC_Human1.09418758
108TAF15_26573619_Chip-Seq_HEK293_Human1.08695130
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.07760819
110NANOG_20526341_ChIP-Seq_ESCs_Human1.05728188
111HOXB7_26014856_ChIP-Seq_BT474_Human1.05277051
112POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04951744
113* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04779566
114CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04702747
115EZH2_27294783_Chip-Seq_NPCs_Mouse1.04185063
116SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03796338
117CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03697362
118EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03507098
119MYC_19829295_ChIP-Seq_ESCs_Human1.02734233
120GATA3_27048872_Chip-Seq_THYMUS_Human1.02716000
121AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00852577
122BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00728884
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99971145
124* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99951763
125KDM5A_27292631_Chip-Seq_BREAST_Human0.99452353
126AR_25329375_ChIP-Seq_VCAP_Human0.99319591
127CBX2_27304074_Chip-Seq_ESCs_Mouse0.99022856
128CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98734566
129ERA_21632823_ChIP-Seq_H3396_Human0.98393637
130FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96681992
131AR_21572438_ChIP-Seq_LNCaP_Human0.96195077
132PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95487227
133GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95110289
134FOXH1_21741376_ChIP-Seq_EPCs_Human0.94425021
135GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94382742
136TCF4_23295773_ChIP-Seq_U87_Human0.93129058
137CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92838395
138PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92614947
139NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91758595
140RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91659463
141CRX_20693478_ChIP-Seq_RETINA_Mouse0.91344022
142FLI1_21867929_ChIP-Seq_TH2_Mouse0.91020608
143PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90988447
144FOXH1_21741376_ChIP-Seq_ESCs_Human0.90970682
145LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88020533
146CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87054004
147FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86671421
148STAT4_19710469_ChIP-ChIP_TH1__Mouse0.85848831
149* SPI1_23547873_ChIP-Seq_NB4_Human0.84394344
150FLI1_27457419_Chip-Seq_LIVER_Mouse0.83301995
151SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82427172
152MYCN_18555785_ChIP-Seq_MESCs_Mouse0.82409619
153MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.81643095
154RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.80960565
155YY1_22570637_ChIP-Seq_MALME-3M_Human0.80743179
156IRF1_19129219_ChIP-ChIP_H3396_Human0.80291402
157POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.80240373
158GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78687617
159STAT1_20625510_ChIP-Seq_HELA_Human0.78556469
160TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78436089
161RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.76069354
162FOXM1_23109430_ChIP-Seq_U2OS_Human0.75487845
163SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75353922
164PU.1_20513432_ChIP-Seq_Bcells_Mouse0.75105747
165ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.74138342
166POU3F2_20337985_ChIP-ChIP_501MEL_Human0.71834025
167PCGF2_27294783_Chip-Seq_ESCs_Mouse0.70504411
168TFEB_21752829_ChIP-Seq_HELA_Human0.68429179

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.82956678
2MP0001529_abnormal_vocalization2.95221959
3MP0001905_abnormal_dopamine_level2.60960801
4MP0003195_calcinosis2.60483655
5MP0009379_abnormal_foot_pigmentation2.53371347
6MP0001986_abnormal_taste_sensitivity2.39458398
7MP0005423_abnormal_somatic_nervous2.32485625
8MP0002837_dystrophic_cardiac_calcinosis2.24179726
9MP0002638_abnormal_pupillary_reflex2.19359330
10MP0003763_abnormal_thymus_physiology2.12209516
11MP0008875_abnormal_xenobiotic_pharmacok2.00219659
12MP0002653_abnormal_ependyma_morphology1.95885209
13MP0005671_abnormal_response_to1.91860212
14MP0006292_abnormal_olfactory_placode1.87951655
15MP0006276_abnormal_autonomic_nervous1.84684987
16MP0002272_abnormal_nervous_system1.83128276
17MP0003011_delayed_dark_adaptation1.76666232
18MP0006036_abnormal_mitochondrial_physio1.75102934
19MP0002736_abnormal_nociception_after1.73977187
20MP0005551_abnormal_eye_electrophysiolog1.68294569
21MP0001968_abnormal_touch/_nociception1.67935704
22MP0004742_abnormal_vestibular_system1.65305842
23MP0003693_abnormal_embryo_hatching1.64657071
24MP0004142_abnormal_muscle_tone1.64334461
25MP0001188_hyperpigmentation1.62354730
26MP0004145_abnormal_muscle_electrophysio1.60542170
27MP0002064_seizures1.58897215
28MP0003646_muscle_fatigue1.58632024
29MP0002138_abnormal_hepatobiliary_system1.56960179
30MP0004885_abnormal_endolymph1.55286880
31MP0009745_abnormal_behavioral_response1.54215168
32MP0000372_irregular_coat_pigmentation1.50917953
33MP0008058_abnormal_DNA_repair1.50792052
34MP0006072_abnormal_retinal_apoptosis1.50648170
35MP0005409_darkened_coat_color1.49670790
36MP0005645_abnormal_hypothalamus_physiol1.48331520
37MP0009764_decreased_sensitivity_to1.48053547
38MP0002163_abnormal_gland_morphology1.47030730
39MP0003635_abnormal_synaptic_transmissio1.46982693
40MP0002822_catalepsy1.46770691
41MP0004147_increased_porphyrin_level1.44232832
42MP0004957_abnormal_blastocyst_morpholog1.43921944
43MP0005379_endocrine/exocrine_gland_phen1.43873676
44MP0002277_abnormal_respiratory_mucosa1.41654154
45MP0008877_abnormal_DNA_methylation1.38005958
46MP0002102_abnormal_ear_morphology1.37182584
47MP0002572_abnormal_emotion/affect_behav1.36324614
48MP0002735_abnormal_chemical_nociception1.33817241
49MP0009046_muscle_twitch1.31939508
50MP0005084_abnormal_gallbladder_morpholo1.31482725
51MP0000631_abnormal_neuroendocrine_gland1.30279319
52MP0003077_abnormal_cell_cycle1.27071827
53MP0008932_abnormal_embryonic_tissue1.25658461
54MP0005253_abnormal_eye_physiology1.25505188
55MP0001919_abnormal_reproductive_system1.25324609
56MP0010386_abnormal_urinary_bladder1.25216291
57MP0000685_abnormal_immune_system1.24844135
58MP0004036_abnormal_muscle_relaxation1.24151340
59MP0008260_abnormal_autophagy1.23796051
60MP0002734_abnormal_mechanical_nocicepti1.23563971
61MP0008995_early_reproductive_senescence1.23562276
62MP0001485_abnormal_pinna_reflex1.23499437
63MP0009333_abnormal_splenocyte_physiolog1.22939596
64MP0001835_abnormal_antigen_presentation1.22452190
65MP0004215_abnormal_myocardial_fiber1.21760812
66MP0001790_abnormal_immune_system1.21547999
67MP0005387_immune_system_phenotype1.21547999
68MP0001970_abnormal_pain_threshold1.20634517
69MP0002452_abnormal_antigen_presenting1.20185720
70MP0008057_abnormal_DNA_replication1.19546252
71MP0002067_abnormal_sensory_capabilities1.19205714
72MP0000569_abnormal_digit_pigmentation1.18849286
73MP0005389_reproductive_system_phenotype1.17863539
74MP0010094_abnormal_chromosome_stability1.15726926
75MP0001486_abnormal_startle_reflex1.15614171
76MP0006035_abnormal_mitochondrial_morpho1.15473114
77MP0002148_abnormal_hypersensitivity_rea1.14684965
78MP0001873_stomach_inflammation1.14458647
79MP0003656_abnormal_erythrocyte_physiolo1.14346280
80MP0004133_heterotaxia1.12891965
81MP0003718_maternal_effect1.11447469
82MP0005174_abnormal_tail_pigmentation1.09750268
83MP0003638_abnormal_response/metabolism_1.07323006
84MP0008775_abnormal_heart_ventricle1.04632686
85MP0002063_abnormal_learning/memory/cond1.04391413
86MP0002557_abnormal_social/conspecific_i1.00679927
87MP0001440_abnormal_grooming_behavior1.00349283
88MP0008569_lethality_at_weaning1.00161888
89MP0004924_abnormal_behavior0.99352224
90MP0005386_behavior/neurological_phenoty0.99352224
91MP0005000_abnormal_immune_tolerance0.99294234
92MP0003787_abnormal_imprinting0.98881230
93MP0002928_abnormal_bile_duct0.98803817
94MP0000230_abnormal_systemic_arterial0.96933302
95MP0002723_abnormal_immune_serum0.95567647
96MP0001502_abnormal_circadian_rhythm0.95498046
97MP0004130_abnormal_muscle_cell0.95186544
98MP0002876_abnormal_thyroid_physiology0.95053728
99MP0004859_abnormal_synaptic_plasticity0.94828891
100MP0002420_abnormal_adaptive_immunity0.93706069
101MP0001501_abnormal_sleep_pattern0.93697990
102MP0000749_muscle_degeneration0.93135634
103MP0004084_abnormal_cardiac_muscle0.92895398
104MP0001819_abnormal_immune_cell0.91765926
105MP0002398_abnormal_bone_marrow0.91009448
106MP0000703_abnormal_thymus_morphology0.90883792
107MP0001800_abnormal_humoral_immune0.90284517
108MP0005646_abnormal_pituitary_gland0.89620324
109MP0003111_abnormal_nucleus_morphology0.89331966
110MP0004270_analgesia0.89057414
111MP0003786_premature_aging0.88998677
112MP0009785_altered_susceptibility_to0.88384013
113MP0002693_abnormal_pancreas_physiology0.88121477
114MP0008872_abnormal_physiological_respon0.87734895
115MP0003724_increased_susceptibility_to0.87346239
116MP0002132_abnormal_respiratory_system0.87160990
117MP0000716_abnormal_immune_system0.86293365
118MP0003436_decreased_susceptibility_to0.86182879
119MP0002419_abnormal_innate_immunity0.85852808
120MP0003136_yellow_coat_color0.85134717
121MP0005075_abnormal_melanosome_morpholog0.84786829
122MP0003879_abnormal_hair_cell0.84145611
123MP0000689_abnormal_spleen_morphology0.84129156
124MP0003866_abnormal_defecation0.83746688
125MP0005025_abnormal_response_to0.83711528
126MP0005332_abnormal_amino_acid0.83020665
127MP0001727_abnormal_embryo_implantation0.82373557
128MP0000920_abnormal_myelination0.82129459
129MP0002933_joint_inflammation0.81921888
130MP0002160_abnormal_reproductive_system0.80961890
131MP0002229_neurodegeneration0.80543437
132MP0002184_abnormal_innervation0.80372016
133MP0006082_CNS_inflammation0.79733878
134MP0003137_abnormal_impulse_conducting0.79485295
135MP0002722_abnormal_immune_system0.79149497
136MP0002733_abnormal_thermal_nociception0.78870291
137MP0005410_abnormal_fertilization0.77831618
138MP0001845_abnormal_inflammatory_respons0.77763141
139MP0004043_abnormal_pH_regulation0.75860458
140MP0001963_abnormal_hearing_physiology0.75465584
141MP0003252_abnormal_bile_duct0.72409648
142MP0001853_heart_inflammation0.72207880
143MP0002405_respiratory_system_inflammati0.71731875

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.12047604
2Mitochondrial inheritance (HP:0001427)5.70650104
3Abnormal mitochondria in muscle tissue (HP:0008316)5.64682895
4Hepatocellular necrosis (HP:0001404)5.28541753
5Increased CSF lactate (HP:0002490)5.00157973
6Progressive macrocephaly (HP:0004481)4.84825660
7Acute encephalopathy (HP:0006846)4.73580562
8Hepatic necrosis (HP:0002605)4.44732648
9Increased hepatocellular lipid droplets (HP:0006565)4.22168476
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.95040467
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.95040467
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.86507068
13Lipid accumulation in hepatocytes (HP:0006561)3.77419329
14Renal Fanconi syndrome (HP:0001994)3.71784958
15Increased serum pyruvate (HP:0003542)3.66303227
16Abnormality of glycolysis (HP:0004366)3.66303227
17Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.63553816
18Optic disc pallor (HP:0000543)3.51723289
19Stomach cancer (HP:0012126)3.41476173
20Increased intramyocellular lipid droplets (HP:0012240)3.39398741
21Increased serum lactate (HP:0002151)3.37709921
22Respiratory failure (HP:0002878)3.34165220
23Exercise intolerance (HP:0003546)3.24892093
24Molar tooth sign on MRI (HP:0002419)3.17068846
25Abnormality of midbrain morphology (HP:0002418)3.17068846
26Lactic acidosis (HP:0003128)3.09618241
27Nephronophthisis (HP:0000090)3.05122351
28Exertional dyspnea (HP:0002875)3.04312367
29Leukodystrophy (HP:0002415)3.00350467
30Stomatitis (HP:0010280)2.92743224
31Abnormal number of erythroid precursors (HP:0012131)2.91170802
32Increased muscle lipid content (HP:0009058)2.90921091
33Abnormality of cells of the erythroid lineage (HP:0012130)2.90675441
34Cerebral edema (HP:0002181)2.87898149
35Abolished electroretinogram (ERG) (HP:0000550)2.80652549
36Abnormality of the renal cortex (HP:0011035)2.80623877
373-Methylglutaconic aciduria (HP:0003535)2.80444264
38Respiratory difficulties (HP:0002880)2.77302592
39Reticulocytopenia (HP:0001896)2.76387417
40Attenuation of retinal blood vessels (HP:0007843)2.71836599
41Cerebral hypomyelination (HP:0006808)2.65649731
42Abnormal hair whorl (HP:0010721)2.64220640
43Elevated erythrocyte sedimentation rate (HP:0003565)2.60293801
44Aplastic anemia (HP:0001915)2.58088770
45Type II lissencephaly (HP:0007260)2.57739673
46Renal cortical cysts (HP:0000803)2.56143800
47Abnormality of the renal medulla (HP:0100957)2.55881582
48Progressive cerebellar ataxia (HP:0002073)2.50725958
49Pendular nystagmus (HP:0012043)2.49187410
50Decreased electroretinogram (ERG) amplitude (HP:0000654)2.46842996
51Methylmalonic aciduria (HP:0012120)2.46029127
52Methylmalonic acidemia (HP:0002912)2.45478595
53Congenital, generalized hypertrichosis (HP:0004540)2.44334905
54Emotional lability (HP:0000712)2.43725104
55Medial flaring of the eyebrow (HP:0010747)2.41203950
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.38875253
57Thyroiditis (HP:0100646)2.36991129
58CNS demyelination (HP:0007305)2.35113776
59Decreased central vision (HP:0007663)2.33452290
60Macrocytic anemia (HP:0001972)2.29979107
61Agitation (HP:0000713)2.28956799
62Congenital stationary night blindness (HP:0007642)2.25360904
63Abnormality of renal resorption (HP:0011038)2.25207451
64Cystic liver disease (HP:0006706)2.22542262
65Aplasia/hypoplasia of the uterus (HP:0008684)2.20476671
66Pallor (HP:0000980)2.16922472
67Aplasia/Hypoplasia of the sacrum (HP:0008517)2.15905820
68Gaze-evoked nystagmus (HP:0000640)2.13642120
69Abnormality of B cell number (HP:0010975)2.11208126
70Microvesicular hepatic steatosis (HP:0001414)2.10194714
71Panhypogammaglobulinemia (HP:0003139)2.10169680
72Poor suck (HP:0002033)2.09971333
73Congenital primary aphakia (HP:0007707)2.08627821
74Aplasia/Hypoplasia of the fovea (HP:0008060)2.06883781
75Hypoplasia of the fovea (HP:0007750)2.06883781
76Genetic anticipation (HP:0003743)2.06452809
77Increased IgM level (HP:0003496)2.06341434
78Focal motor seizures (HP:0011153)2.05508995
79Secondary amenorrhea (HP:0000869)2.04614936
80Gait imbalance (HP:0002141)2.03116589
81Hemiparesis (HP:0001269)2.01277098
82X-linked dominant inheritance (HP:0001423)2.01199681
83Sclerocornea (HP:0000647)2.00963827
84Inability to walk (HP:0002540)1.98954658
85Unsteady gait (HP:0002317)1.98836218
86Birth length less than 3rd percentile (HP:0003561)1.98036041
87Atonic seizures (HP:0010819)1.97929374
88Abnormality of the prostate (HP:0008775)1.97541164
89Polydipsia (HP:0001959)1.97342685
90Abnormal drinking behavior (HP:0030082)1.97342685
91Furrowed tongue (HP:0000221)1.97234213
92Nephrogenic diabetes insipidus (HP:0009806)1.96818386
93Retrobulbar optic neuritis (HP:0100654)1.96398152
94Optic neuritis (HP:0100653)1.96398152
95Hypothermia (HP:0002045)1.95810762
96Myositis (HP:0100614)1.94956823
97Concave nail (HP:0001598)1.94609991
98Male pseudohermaphroditism (HP:0000037)1.91578065
99Congenital sensorineural hearing impairment (HP:0008527)1.91451772
100Abnormality of alanine metabolism (HP:0010916)1.91440386
101Hyperalaninemia (HP:0003348)1.91440386
102Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91440386
103Brushfield spots (HP:0001088)1.91384415
104Progressive external ophthalmoplegia (HP:0000590)1.90444393
105Abnormality of T cells (HP:0002843)1.90050123
106Abnormality of T cell physiology (HP:0011840)1.89526821
107Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.89515687
108Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.89150660
109Breast hypoplasia (HP:0003187)1.88607561
110Hyperphosphaturia (HP:0003109)1.87817868
111Progressive inability to walk (HP:0002505)1.87705724
112Increased corneal curvature (HP:0100692)1.87324861
113Keratoconus (HP:0000563)1.87324861
114Aplasia/Hypoplasia of the tibia (HP:0005772)1.87254789
115Pancytopenia (HP:0001876)1.85458220
116Abnormal rod and cone electroretinograms (HP:0008323)1.84123232
117Aplasia/Hypoplasia of the spleen (HP:0010451)1.83329727
118Severe combined immunodeficiency (HP:0004430)1.83169786
119Recurrent cutaneous fungal infections (HP:0011370)1.81642074
120Chronic mucocutaneous candidiasis (HP:0002728)1.81642074
121IgG deficiency (HP:0004315)1.81351758
122True hermaphroditism (HP:0010459)1.80598839
123Menstrual irregularities (HP:0000858)1.80234425
124Dynein arm defect of respiratory motile cilia (HP:0012255)1.77775683
125Absent/shortened dynein arms (HP:0200106)1.77775683
126Abnormality of the heme biosynthetic pathway (HP:0010472)1.77389492
127Severe visual impairment (HP:0001141)1.76212136
128Abnormality of T cell number (HP:0011839)1.75835567
129Ketosis (HP:0001946)1.75087610
130Abnormality of the phalanges of the 2nd finger (HP:0009541)1.74669081
131Abnormality of the fovea (HP:0000493)1.74530674
132Asplenia (HP:0001746)1.73639791
133Progressive microcephaly (HP:0000253)1.73454266
134IgM deficiency (HP:0002850)1.73357290
135Rough bone trabeculation (HP:0100670)1.73078645
136Polyuria (HP:0000103)1.72794639
137Type I transferrin isoform profile (HP:0003642)1.72388577
138Bony spicule pigmentary retinopathy (HP:0007737)1.71920425
139Pancreatic fibrosis (HP:0100732)1.71244030
140Seborrheic dermatitis (HP:0001051)1.71143963
141Tubular atrophy (HP:0000092)1.70411877
142Absent rod-and cone-mediated responses on ERG (HP:0007688)1.69271241
143Neutropenia (HP:0001875)1.68888136
144CNS hypomyelination (HP:0003429)1.68562681
145Severe muscular hypotonia (HP:0006829)1.67975711
146Short tibia (HP:0005736)1.67695720
147Patellar aplasia (HP:0006443)1.67419328
148Large for gestational age (HP:0001520)1.66142738
149Hypoplasia of the uterus (HP:0000013)1.65840590
150Absent thumb (HP:0009777)1.65188754
151Orchitis (HP:0100796)1.63825413
152Autoimmune thrombocytopenia (HP:0001973)1.63064737
153Gliosis (HP:0002171)1.62940742
154Female pseudohermaphroditism (HP:0010458)1.62349124
155Abnormality of placental membranes (HP:0011409)1.61926573
156Amniotic constriction ring (HP:0009775)1.61926573
157Ragged-red muscle fibers (HP:0003200)1.59957335
158Blindness (HP:0000618)1.57965139
159Oral leukoplakia (HP:0002745)1.56575596
160Delusions (HP:0000746)1.56351180
161Abnormality of eosinophils (HP:0001879)1.56097372
162Parakeratosis (HP:0001036)1.55421095
163Pancreatic cysts (HP:0001737)1.54195740
164Epileptic encephalopathy (HP:0200134)1.54127392
165Aplasia/Hypoplasia of the patella (HP:0006498)1.53942038
166Neuroendocrine neoplasm (HP:0100634)1.52948504
167Dialeptic seizures (HP:0011146)1.52072737
168Broad-based gait (HP:0002136)1.50505956
169Myokymia (HP:0002411)1.49659955
170Glycosuria (HP:0003076)1.49499435

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.67225190
2FRK4.60869610
3TAOK34.20220052
4ZAK3.65958237
5PBK3.23815394
6MAP3K123.11801093
7BUB13.00628337
8CASK2.87813177
9STK162.74704326
10GRK12.72256467
11EIF2AK32.51872496
12TXK2.39241374
13NME12.35680554
14INSRR2.34848712
15ARAF2.25790125
16TLK12.18754109
17PINK12.16878919
18VRK12.11592610
19NUAK12.09641616
20MAP4K22.09144077
21WNK32.02771417
22CCNB11.95326996
23MAP4K11.92951026
24MAP3K111.92617460
25NME21.88658151
26ACVR1B1.81254998
27IKBKB1.68495701
28MST41.63498773
29BMPR1B1.61775930
30MYLK1.59952243
31WNK41.58156228
32PNCK1.54824663
33SRPK11.42723532
34ADRBK21.41536333
35MAP3K131.41443589
36TNK21.40948717
37MUSK1.35503296
38TSSK61.34385581
39PIM21.28264338
40WEE11.27909724
41VRK21.23183634
42ITK1.20417618
43BRSK11.19862540
44BCKDK1.12306012
45BRAF1.11965752
46PLK41.11580752
47DAPK21.11521069
48MAPKAPK51.10927686
49GRK71.07880486
50MKNK21.06662684
51CDK190.98605435
52MAPKAPK30.95492622
53RPS6KA50.95454796
54IRAK40.95133677
55MKNK10.93045259
56KDR0.88133271
57BLK0.87669415
58TNIK0.86720557
59PAK30.86381914
60MAP2K70.84843401
61PTK2B0.81751500
62BMPR20.81712493
63TESK20.81630501
64ZAP700.81301306
65MAPK150.80309141
66KIT0.80283900
67FGFR20.79363724
68MAP2K20.78772889
69CSF1R0.78433247
70IRAK30.78068565
71SIK30.77710680
72TEC0.77221770
73CSNK1G30.76761999
74FES0.76120909
75PRKCG0.75478503
76STK390.74831563
77PRKCE0.73241369
78AKT30.72865703
79BCR0.72606681
80PRKD20.72263065
81OBSCN0.70506019
82EIF2AK20.70234970
83PIK3CA0.69864423
84CSNK1G20.69687769
85DAPK10.69055438
86CAMK2B0.68015387
87UHMK10.67306426
88OXSR10.67160647
89IKBKE0.66473891
90ADRBK10.65378079
91CSNK1G10.62693738
92DYRK30.62455774
93MAP3K40.61658930
94CHUK0.61269249
95AURKA0.60250580
96SYK0.59541294
97RIPK40.58508331
98LCK0.58425410
99MATK0.57519209
100TBK10.57296886
101NLK0.56307614
102EPHB10.55223217
103GRK50.55132961
104CSNK1A1L0.54987958
105PHKG10.54662517
106PHKG20.54662517
107SIK20.54462519
108JAK30.53546105
109LYN0.52289276
110CAMK2A0.51896839
111PRKACA0.51275326
112NTRK30.51237944
113TIE10.51208801
114DYRK20.50925349
115PLK20.50654567
116RPS6KA40.50244546
117MAPK130.50138088
118MARK30.49613031
119PLK10.48485511
120FLT30.48310061
121RAF10.47487503
122CSNK1A10.46745676
123MAPK70.46709334
124PRKCA0.44708382
125CAMK2G0.43407815
126IRAK10.43086991
127DYRK1A0.42059167
128CAMKK20.41498687
129PRKCI0.41445586
130PIM10.41236072
131CAMKK10.41174598
132GRK60.41038726
133STK110.40843729
134ERBB30.40297777
135CDK80.40188971
136EPHA40.39353016
137PRKCQ0.39189471
138DAPK30.38889223
139CSNK2A10.38382103
140PLK30.38345127
141TYK20.38218072
142ERBB20.37022753
143CAMK2D0.36550988
144RPS6KC10.36347362
145RPS6KL10.36347362
146BTK0.36336565
147RPS6KA60.35984156
148IGF1R0.35676809
149HCK0.35553081
150PASK0.34564148
151FGR0.33898567
152MAP2K60.32420409
153PKN10.31868504
154ABL10.31519257
155MAP3K140.31329123
156CAMK10.31322723
157STK240.30852805

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.81504706
2Ribosome_Homo sapiens_hsa030104.28979098
3Proteasome_Homo sapiens_hsa030504.17115822
4Parkinsons disease_Homo sapiens_hsa050124.15331351
5RNA polymerase_Homo sapiens_hsa030203.45754596
6Huntingtons disease_Homo sapiens_hsa050163.08746632
7Alzheimers disease_Homo sapiens_hsa050103.07639462
8Protein export_Homo sapiens_hsa030602.70604177
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.45935274
10Caffeine metabolism_Homo sapiens_hsa002322.18217325
11Cardiac muscle contraction_Homo sapiens_hsa042602.13369400
12Homologous recombination_Homo sapiens_hsa034402.13218172
13* Spliceosome_Homo sapiens_hsa030402.11682867
14Mismatch repair_Homo sapiens_hsa034302.11429454
15Phototransduction_Homo sapiens_hsa047442.07338913
16DNA replication_Homo sapiens_hsa030302.04571202
17Nitrogen metabolism_Homo sapiens_hsa009102.00360396
18Linoleic acid metabolism_Homo sapiens_hsa005911.95865491
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.87568532
20Pyrimidine metabolism_Homo sapiens_hsa002401.87020015
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.81948349
22Collecting duct acid secretion_Homo sapiens_hsa049661.74354644
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69177641
24Base excision repair_Homo sapiens_hsa034101.68940250
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.67109937
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67039742
27Primary immunodeficiency_Homo sapiens_hsa053401.61944665
28Nucleotide excision repair_Homo sapiens_hsa034201.61673283
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.57907647
30Basal transcription factors_Homo sapiens_hsa030221.48350528
31RNA degradation_Homo sapiens_hsa030181.45117587
32Tryptophan metabolism_Homo sapiens_hsa003801.41673348
33Nicotine addiction_Homo sapiens_hsa050331.38737468
34Purine metabolism_Homo sapiens_hsa002301.33891087
35Butanoate metabolism_Homo sapiens_hsa006501.31393324
36Non-homologous end-joining_Homo sapiens_hsa034501.24876845
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24798846
38RNA transport_Homo sapiens_hsa030131.17600200
39Fanconi anemia pathway_Homo sapiens_hsa034601.15757563
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14688839
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12951861
42Chemical carcinogenesis_Homo sapiens_hsa052041.12182919
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10141150
44Selenocompound metabolism_Homo sapiens_hsa004501.02247067
45Synaptic vesicle cycle_Homo sapiens_hsa047211.00813009
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97578509
47Peroxisome_Homo sapiens_hsa041460.96923137
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95154805
49Vibrio cholerae infection_Homo sapiens_hsa051100.92462009
50Sulfur metabolism_Homo sapiens_hsa009200.90941387
51Staphylococcus aureus infection_Homo sapiens_hsa051500.89835667
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89430720
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85500890
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83025622
55Fatty acid elongation_Homo sapiens_hsa000620.82854930
56Epstein-Barr virus infection_Homo sapiens_hsa051690.82216106
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79851456
58Folate biosynthesis_Homo sapiens_hsa007900.79533303
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77061539
60Glycerolipid metabolism_Homo sapiens_hsa005610.76313830
61Rheumatoid arthritis_Homo sapiens_hsa053230.73670518
62Morphine addiction_Homo sapiens_hsa050320.72316149
63Serotonergic synapse_Homo sapiens_hsa047260.70132170
64Regulation of autophagy_Homo sapiens_hsa041400.69097996
65Retinol metabolism_Homo sapiens_hsa008300.68662306
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.67850694
67GABAergic synapse_Homo sapiens_hsa047270.66601675
68Cell cycle_Homo sapiens_hsa041100.66053123
69Hematopoietic cell lineage_Homo sapiens_hsa046400.65050481
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61782826
71Allograft rejection_Homo sapiens_hsa053300.61656440
72Vitamin B6 metabolism_Homo sapiens_hsa007500.61311830
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60416912
74Type I diabetes mellitus_Homo sapiens_hsa049400.52716817
75Circadian entrainment_Homo sapiens_hsa047130.52144372
76Taste transduction_Homo sapiens_hsa047420.50932185
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.50503457
78Metabolic pathways_Homo sapiens_hsa011000.49828993
79Leishmaniasis_Homo sapiens_hsa051400.49118104
80Ether lipid metabolism_Homo sapiens_hsa005650.48931776
81Fat digestion and absorption_Homo sapiens_hsa049750.48865251
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.48386980
83T cell receptor signaling pathway_Homo sapiens_hsa046600.48061270
84Olfactory transduction_Homo sapiens_hsa047400.45514335
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45431777
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44956890
87Glutamatergic synapse_Homo sapiens_hsa047240.44443677
88Autoimmune thyroid disease_Homo sapiens_hsa053200.44347851
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.43985437
90Other glycan degradation_Homo sapiens_hsa005110.43906891
91Graft-versus-host disease_Homo sapiens_hsa053320.43715024
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43473167
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42819084
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42626344
95ABC transporters_Homo sapiens_hsa020100.41901146
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41900859
97Herpes simplex infection_Homo sapiens_hsa051680.39290649
98Long-term depression_Homo sapiens_hsa047300.38949930
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38738555
100Measles_Homo sapiens_hsa051620.38315381
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37870157
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37317337
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35746831
104Alcoholism_Homo sapiens_hsa050340.35150867
105Pyruvate metabolism_Homo sapiens_hsa006200.34634212
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33428302
107Calcium signaling pathway_Homo sapiens_hsa040200.33373966
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.33285054
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.32379969
110Dopaminergic synapse_Homo sapiens_hsa047280.32204748
111Oocyte meiosis_Homo sapiens_hsa041140.32009370
112Amphetamine addiction_Homo sapiens_hsa050310.31866117
113Ovarian steroidogenesis_Homo sapiens_hsa049130.30366515
114Vitamin digestion and absorption_Homo sapiens_hsa049770.29937644
115p53 signaling pathway_Homo sapiens_hsa041150.29767444
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29089959
117Circadian rhythm_Homo sapiens_hsa047100.28766639
118African trypanosomiasis_Homo sapiens_hsa051430.27725082
119mRNA surveillance pathway_Homo sapiens_hsa030150.27308765
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25022431
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.23868050
122Cholinergic synapse_Homo sapiens_hsa047250.22240688
123Insulin secretion_Homo sapiens_hsa049110.21218061
124Antigen processing and presentation_Homo sapiens_hsa046120.21148612
125Arachidonic acid metabolism_Homo sapiens_hsa005900.20732693
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.19636162
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18954975
128Renin secretion_Homo sapiens_hsa049240.18531584
129Sphingolipid metabolism_Homo sapiens_hsa006000.18293666
130Sulfur relay system_Homo sapiens_hsa041220.17636766
131Cocaine addiction_Homo sapiens_hsa050300.17204264
132Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.16896780
133Salivary secretion_Homo sapiens_hsa049700.16199169
134Asthma_Homo sapiens_hsa053100.16029974
135Systemic lupus erythematosus_Homo sapiens_hsa053220.15256420
136Long-term potentiation_Homo sapiens_hsa047200.14510006
137Phagosome_Homo sapiens_hsa041450.13432088

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