U2AF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.93082636
2DNA unwinding involved in DNA replication (GO:0006268)4.68533886
3regulation of translational fidelity (GO:0006450)4.35002903
4nuclear pore complex assembly (GO:0051292)4.34569284
5protein localization to kinetochore (GO:0034501)4.28427064
6heterochromatin organization (GO:0070828)4.27233924
7nuclear pore organization (GO:0006999)4.23958834
8Golgi transport vesicle coating (GO:0048200)4.18416337
9COPI coating of Golgi vesicle (GO:0048205)4.18416337
10RNA stabilization (GO:0043489)4.02411868
11mRNA stabilization (GO:0048255)4.02411868
12regulation of mammary gland epithelial cell proliferation (GO:0033599)3.93514369
13negative regulation of erythrocyte differentiation (GO:0045647)3.89826414
14proline biosynthetic process (GO:0006561)3.83014276
15folic acid-containing compound biosynthetic process (GO:0009396)3.81896744
16regulation of gene silencing by RNA (GO:0060966)3.78088801
17regulation of posttranscriptional gene silencing (GO:0060147)3.78088801
18regulation of gene silencing by miRNA (GO:0060964)3.78088801
19negative regulation of histone methylation (GO:0031061)3.76875084
20peptidyl-lysine dimethylation (GO:0018027)3.76033346
21regulation of translational termination (GO:0006449)3.69049221
22spliceosomal tri-snRNP complex assembly (GO:0000244)3.60734949
23sister chromatid segregation (GO:0000819)3.60638911
24chromatin assembly (GO:0031497)3.60226248
25activation of Rac GTPase activity (GO:0032863)3.56375290
26protein localization to endosome (GO:0036010)3.52540563
27positive regulation of histone deacetylation (GO:0031065)3.48761249
28dosage compensation (GO:0007549)3.47372680
29mitotic nuclear envelope disassembly (GO:0007077)3.42239563
30regulation of histone H3-K27 methylation (GO:0061085)3.41764846
31protein localization to chromosome, centromeric region (GO:0071459)3.41224814
32pentose-phosphate shunt (GO:0006098)3.41213669
33DNA duplex unwinding (GO:0032508)3.41041852
34mitotic sister chromatid segregation (GO:0000070)3.40106409
35DNA geometric change (GO:0032392)3.37926588
36peptidyl-arginine omega-N-methylation (GO:0035247)3.35188414
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.34572186
38maternal placenta development (GO:0001893)3.31148469
39regulation of histone H3-K9 methylation (GO:0051570)3.30167697
40glucocorticoid receptor signaling pathway (GO:0042921)3.28800019
41regulation of NFAT protein import into nucleus (GO:0051532)3.28627445
42membrane disassembly (GO:0030397)3.27819612
43nuclear envelope disassembly (GO:0051081)3.27819612
44regulation of hippo signaling (GO:0035330)3.27608879
45DNA replication-dependent nucleosome assembly (GO:0006335)3.25637968
46DNA replication-dependent nucleosome organization (GO:0034723)3.25637968
47regulation of RNA export from nucleus (GO:0046831)3.24619818
48regulation of early endosome to late endosome transport (GO:2000641)3.24362461
49mitotic G1 DNA damage checkpoint (GO:0031571)3.22392362
50regulation of glucose import in response to insulin stimulus (GO:2001273)3.21165642
51establishment of apical/basal cell polarity (GO:0035089)3.19497586
523-UTR-mediated mRNA stabilization (GO:0070935)3.18815151
53NLS-bearing protein import into nucleus (GO:0006607)3.18041302
54mitotic chromosome condensation (GO:0007076)3.16859270
55* negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.14640736
56regulation of sister chromatid cohesion (GO:0007063)3.13185757
57intracellular estrogen receptor signaling pathway (GO:0030520)3.07680674
58positive regulation of SMAD protein import into nucleus (GO:0060391)3.06335751
59retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.06069278
60regulation of mRNA stability (GO:0043488)3.06035220
61pore complex assembly (GO:0046931)3.05968947
62cellular protein complex localization (GO:0034629)3.05673455
63histone H2A monoubiquitination (GO:0035518)3.05407636
64apoptotic process involved in morphogenesis (GO:0060561)3.04431694
65ribosomal small subunit biogenesis (GO:0042274)3.04024534
66protein complex localization (GO:0031503)3.02512517
67peptidyl-arginine N-methylation (GO:0035246)3.01913640
68peptidyl-arginine methylation (GO:0018216)3.01913640
69protein retention in ER lumen (GO:0006621)3.01061945
70polarized epithelial cell differentiation (GO:0030859)2.99409562
71mitotic sister chromatid cohesion (GO:0007064)2.99117573
72maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.98904849
73positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.98138623
74alternative mRNA splicing, via spliceosome (GO:0000380)2.96863171
75formation of translation preinitiation complex (GO:0001731)2.95314973
76trophectodermal cell differentiation (GO:0001829)2.92550435
77cell-substrate junction assembly (GO:0007044)2.91337551
78NADPH regeneration (GO:0006740)2.90558229
79* negative regulation of RNA splicing (GO:0033119)2.90482350
80positive regulation of chromosome segregation (GO:0051984)2.89301841
81IMP biosynthetic process (GO:0006188)2.87904173
82glucose catabolic process (GO:0006007)2.86827471
83protein export from nucleus (GO:0006611)2.86030296
84mitotic G1/S transition checkpoint (GO:0044819)2.85871522
85regulation of RNA stability (GO:0043487)2.85415590
86embryonic process involved in female pregnancy (GO:0060136)2.84117923
87negative regulation of cell size (GO:0045792)2.82575528
88adherens junction assembly (GO:0034333)2.79821713
89paraxial mesoderm development (GO:0048339)2.78101933
90nuclear envelope organization (GO:0006998)2.77394919
91DNA topological change (GO:0006265)2.77157098
92regulation of chromatin binding (GO:0035561)2.73621531
93cytoplasmic mRNA processing body assembly (GO:0033962)2.73408790
94protein-DNA complex disassembly (GO:0032986)2.72205472
95nucleosome disassembly (GO:0006337)2.72205472
96glucose 6-phosphate metabolic process (GO:0051156)2.70579763
97mannose metabolic process (GO:0006013)2.70084404
98planar cell polarity pathway involved in neural tube closure (GO:0090179)2.69533112
99positive regulation of Cdc42 GTPase activity (GO:0043089)2.68320600
100regulation of nucleobase-containing compound transport (GO:0032239)2.67734184
101DNA replication initiation (GO:0006270)2.67596807
102gene silencing (GO:0016458)2.66348819
103chromatin silencing (GO:0006342)2.66321133
104G1 DNA damage checkpoint (GO:0044783)2.66296868
105corticosteroid receptor signaling pathway (GO:0031958)2.66220686
106DNA strand elongation involved in DNA replication (GO:0006271)2.65414873
107chromosome condensation (GO:0030261)2.64018649
108modulation by symbiont of host cellular process (GO:0044068)2.63930231
109DNA strand elongation (GO:0022616)2.62721869
110positive regulation of gene expression, epigenetic (GO:0045815)2.61878997
111positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.61565626
112regulation of SMAD protein import into nucleus (GO:0060390)2.60983254
113epithelial cell differentiation involved in prostate gland development (GO:0060742)2.60094011
114* negative regulation of mRNA metabolic process (GO:1903312)2.59888169
115modulation by virus of host process (GO:0019054)2.59587739
116* negative regulation of mRNA processing (GO:0050686)2.59121240
117regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.59055778
118positive regulation of nuclease activity (GO:0032075)2.57031613
119activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.56798223
120negative regulation of gene expression, epigenetic (GO:0045814)2.56245069
121establishment or maintenance of monopolar cell polarity (GO:0061339)2.53744191
122establishment of monopolar cell polarity (GO:0061162)2.53744191
123DNA conformation change (GO:0071103)2.53302380
124cell-substrate adherens junction assembly (GO:0007045)2.53182125
125focal adhesion assembly (GO:0048041)2.53182125
126negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.52803677
127nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.52289439
128regulation of gene silencing (GO:0060968)2.51010046
129gene silencing by RNA (GO:0031047)2.50437192
130cellular response to epidermal growth factor stimulus (GO:0071364)2.50289387
131positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.49503501
132regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.49503501
133negative regulation of histone modification (GO:0031057)2.48713254
134cytoskeletal anchoring at plasma membrane (GO:0007016)2.48210438
135negative regulation of viral release from host cell (GO:1902187)2.47400901
136pinocytosis (GO:0006907)2.47061014
137nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.46804860
138positive regulation of protein deacetylation (GO:0090312)2.46773206
139hippo signaling (GO:0035329)2.46191036
140IMP metabolic process (GO:0046040)2.45470784
141chromatin assembly or disassembly (GO:0006333)2.45116541
142T cell apoptotic process (GO:0070231)2.45079978
143histone arginine methylation (GO:0034969)2.44633817
144stress fiber assembly (GO:0043149)2.44336905
145histone H4-K12 acetylation (GO:0043983)2.44334556
146protein localization to microtubule (GO:0035372)2.44324739
147histone H3-K36 demethylation (GO:0070544)2.43726475
148proline metabolic process (GO:0006560)2.42591413
149response to epidermal growth factor (GO:0070849)2.41324002
150response to laminar fluid shear stress (GO:0034616)2.41307318
151positive regulation of blood vessel endothelial cell migration (GO:0043536)2.39715874
152basement membrane organization (GO:0071711)2.36912725
153semaphorin-plexin signaling pathway (GO:0071526)2.36352676
154regulation of nuclease activity (GO:0032069)2.35691004
155nuclear envelope reassembly (GO:0031468)2.34519359

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.89045241
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.84370424
3MYC_22102868_ChIP-Seq_BL_Human3.82429480
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.75104935
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.28012429
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.57556516
7VDR_21846776_ChIP-Seq_THP-1_Human2.50871967
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.46239070
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.27007506
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24401709
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18778277
12KDM2B_26808549_Chip-Seq_DND41_Human2.17323586
13* TCF7_22412390_ChIP-Seq_EML_Mouse2.14941415
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.13780145
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.06172920
16* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.97287136
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95707344
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95172956
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.94587349
20* ELK3_25401928_ChIP-Seq_HUVEC_Human1.89989795
21KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88996045
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.87568414
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.84251017
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78737762
25* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.74351625
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72561208
27ZFP281_27345836_Chip-Seq_ESCs_Mouse1.67012943
28UTX_26944678_Chip-Seq_JUKART_Human1.64854301
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61878562
30CIITA_25753668_ChIP-Seq_RAJI_Human1.59124961
31MAF_26560356_Chip-Seq_TH1_Human1.59005818
32* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55529878
33ZNF263_19887448_ChIP-Seq_K562_Human1.55006441
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54891431
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54533712
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.54051774
37ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.49295164
38CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48785109
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48537220
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47674817
41* XRN2_22483619_ChIP-Seq_HELA_Human1.45586527
42KDM2B_26808549_Chip-Seq_JURKAT_Human1.45254427
43LXR_22292898_ChIP-Seq_THP-1_Human1.43825523
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41794857
45P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40797759
46CLOCK_20551151_ChIP-Seq_293T_Human1.38649986
47DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37317012
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36746506
49* RACK7_27058665_Chip-Seq_MCF-7_Human1.36171523
50* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35741944
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.31868652
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31631037
53* NCOR1_26117541_ChIP-Seq_K562_Human1.29785742
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29731406
55SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28894730
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28865278
57KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28735671
58* ATF3_27146783_Chip-Seq_COLON_Human1.28597484
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27970245
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27853129
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26510594
62* AR_21909140_ChIP-Seq_LNCAP_Human1.25743997
63* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25205277
64CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24083840
65* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23432614
66* KDM5A_27292631_Chip-Seq_BREAST_Human1.23102383
67DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22633402
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21801672
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21594527
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21594527
71KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21594527
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21213905
73NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20275825
74* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20098665
75SA1_27219007_Chip-Seq_ERYTHROID_Human1.19116192
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.18216417
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17904312
78* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17643494
79NANOG_21062744_ChIP-ChIP_HESCs_Human1.15907645
80* VDR_24763502_ChIP-Seq_THP-1_Human1.15198775
81E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12937615
82BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12218197
83KDM2B_26808549_Chip-Seq_K562_Human1.11980513
84THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11735700
85TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11368553
86* RUNX1_22412390_ChIP-Seq_EML_Mouse1.11161569
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10876486
88MAF_26560356_Chip-Seq_TH2_Human1.10796673
89* CHD1_26751641_Chip-Seq_LNCaP_Human1.10766925
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10085017
91* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09574943
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09037777
93GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08940196
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08291816
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06684208
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06669549
97CREB1_26743006_Chip-Seq_LNCaP_Human1.06623950
98ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04661771
99MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04190089
100SMC4_20622854_ChIP-Seq_HELA_Human1.04127006
101* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04122301
102PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03615154
103NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03474694
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02818452
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02778778
106TP53_22127205_ChIP-Seq_IMR90_Human1.02380379
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02156234
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02023100
109MYB_26560356_Chip-Seq_TH1_Human1.01460591
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01373380
111MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01189603
112ERG_21242973_ChIP-ChIP_JURKAT_Human1.00555458
113STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99792208
114MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99469942
115NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98843892
116MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97209918
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97023227
118P68_20966046_ChIP-Seq_HELA_Human0.96881307
119ELF1_20517297_ChIP-Seq_JURKAT_Human0.95828745
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95398816
121TFEB_21752829_ChIP-Seq_HELA_Human0.94502221
122ESR2_21235772_ChIP-Seq_MCF-7_Human0.94490925
123* MYB_26560356_Chip-Seq_TH2_Human0.93660214
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93592657
125UBF1/2_26484160_Chip-Seq_HMECs_Human0.92097728

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.08229771
2MP0010352_gastrointestinal_tract_polyps3.31260718
3MP0005076_abnormal_cell_differentiation3.28349301
4MP0005451_abnormal_body_composition2.74487953
5MP0003111_abnormal_nucleus_morphology2.69685373
6MP0009278_abnormal_bone_marrow2.41517284
7MP0004957_abnormal_blastocyst_morpholog2.35400980
8MP0010234_abnormal_vibrissa_follicle2.27583470
9MP0001730_embryonic_growth_arrest2.25272531
10MP0003077_abnormal_cell_cycle2.22872688
11MP0010094_abnormal_chromosome_stability2.17717860
12MP0003300_gastrointestinal_ulcer2.17076857
13MP0010307_abnormal_tumor_latency2.14495538
14MP0000537_abnormal_urethra_morphology2.09522796
15MP0004197_abnormal_fetal_growth/weight/2.06564026
16MP0001849_ear_inflammation2.03862074
17MP0003303_peritoneal_inflammation2.01724338
18MP0003693_abnormal_embryo_hatching2.00701246
19MP0003566_abnormal_cell_adhesion1.97655575
20MP0003123_paternal_imprinting1.97115511
21MP0000350_abnormal_cell_proliferation1.96792860
22MP0004858_abnormal_nervous_system1.90441269
23MP0002084_abnormal_developmental_patter1.87416138
24MP0001672_abnormal_embryogenesis/_devel1.82471069
25MP0005380_embryogenesis_phenotype1.82471069
26MP0000733_abnormal_muscle_development1.77783212
27MP0002796_impaired_skin_barrier1.76878001
28MP0005058_abnormal_lysosome_morphology1.76855257
29MP0002086_abnormal_extraembryonic_tissu1.74967979
30MP0009053_abnormal_anal_canal1.74534805
31MP0003984_embryonic_growth_retardation1.73649783
32MP0008057_abnormal_DNA_replication1.73514332
33MP0002085_abnormal_embryonic_tissue1.73184390
34MP0002088_abnormal_embryonic_growth/wei1.72361822
35MP0010030_abnormal_orbit_morphology1.72070330
36MP0004185_abnormal_adipocyte_glucose1.72001790
37MP0008260_abnormal_autophagy1.70938973
38MP0001697_abnormal_embryo_size1.65775963
39MP0000678_abnormal_parathyroid_gland1.62324363
40MP0004808_abnormal_hematopoietic_stem1.61594123
41MP0002396_abnormal_hematopoietic_system1.53917992
42MP0002080_prenatal_lethality1.53686141
43MP0008961_abnormal_basal_metabolism1.51808622
44MP0002653_abnormal_ependyma_morphology1.49593319
45MP0005409_darkened_coat_color1.46730439
46MP0002877_abnormal_melanocyte_morpholog1.34482476
47MP0000428_abnormal_craniofacial_morphol1.34421826
48MP0002249_abnormal_larynx_morphology1.34341751
49MP0008007_abnormal_cellular_replicative1.33840347
50MP0003119_abnormal_digestive_system1.33832191
51MP0005023_abnormal_wound_healing1.33363351
52MP0005623_abnormal_meninges_morphology1.31330827
53MP0003567_abnormal_fetal_cardiomyocyte1.28193803
54MP0003283_abnormal_digestive_organ1.26563551
55MP0003115_abnormal_respiratory_system1.24914429
56MP0000703_abnormal_thymus_morphology1.23339614
57MP0001915_intracranial_hemorrhage1.23098624
58MP0009672_abnormal_birth_weight1.21266652
59MP0002060_abnormal_skin_morphology1.21262824
60MP0003121_genomic_imprinting1.21243387
61MP0003436_decreased_susceptibility_to1.20487096
62MP0002925_abnormal_cardiovascular_devel1.18047874
63MP0000490_abnormal_crypts_of1.14333601
64MP0002697_abnormal_eye_size1.14131911
65MP0002092_abnormal_eye_morphology1.10138211
66MP0003091_abnormal_cell_migration1.07750989
67MP0009703_decreased_birth_body1.07673369
68MP0003890_abnormal_embryonic-extraembry1.06478869
69MP0002009_preneoplasia1.05809951
70MP0008770_decreased_survivor_rate1.05657080
71MP0004233_abnormal_muscle_weight1.05070651
72MP0005397_hematopoietic_system_phenotyp1.02995915
73MP0001545_abnormal_hematopoietic_system1.02995915
74MP0002019_abnormal_tumor_incidence1.00581354
75MP0008932_abnormal_embryonic_tissue0.99154173
76MP0003191_abnormal_cellular_cholesterol0.99100054
77MP0000313_abnormal_cell_death0.98619563
78MP0006054_spinal_hemorrhage0.98543453
79MP0003172_abnormal_lysosome_physiology0.97939869
80MP0001873_stomach_inflammation0.97016716
81MP0009840_abnormal_foam_cell0.96107507
82MP0002111_abnormal_tail_morphology0.95138327
83MP0003935_abnormal_craniofacial_develop0.95129583
84MP0001293_anophthalmia0.95128584
85MP0001216_abnormal_epidermal_layer0.94709016
86MP0002398_abnormal_bone_marrow0.94674996
87MP0010630_abnormal_cardiac_muscle0.94310456
88MP0003453_abnormal_keratinocyte_physiol0.91121601
89MP0009931_abnormal_skin_appearance0.90618528
90MP0004272_abnormal_basement_membrane0.90081604
91MP0001346_abnormal_lacrimal_gland0.87827302
92MP0003763_abnormal_thymus_physiology0.87058852
93MP0002722_abnormal_immune_system0.86716489
94MP0001348_abnormal_lacrimal_gland0.85973030
95MP0000266_abnormal_heart_morphology0.85963197
96MP0005666_abnormal_adipose_tissue0.85685450
97MP0004264_abnormal_extraembryonic_tissu0.85486889
98MP0005384_cellular_phenotype0.85314196
99MP0000569_abnormal_digit_pigmentation0.84037553
100MP0000477_abnormal_intestine_morphology0.83488757
101MP0009333_abnormal_splenocyte_physiolog0.83297873
102MP0000685_abnormal_immune_system0.83077156
103MP0003385_abnormal_body_wall0.82373794
104MP0004947_skin_inflammation0.81892739
105MP0000747_muscle_weakness0.81649786
106MP0005375_adipose_tissue_phenotype0.81604691
107MP0002932_abnormal_joint_morphology0.81183247
108MP0001784_abnormal_fluid_regulation0.80261377
109MP0008438_abnormal_cutaneous_collagen0.80218676
110MP0005621_abnormal_cell_physiology0.79445049
111MP0000432_abnormal_head_morphology0.78794231
112MP0003329_amyloid_beta_deposits0.78618023
113MP0000003_abnormal_adipose_tissue0.77815994
114MP0003861_abnormal_nervous_system0.77265020
115MP0005501_abnormal_skin_physiology0.77157533
116MP0000534_abnormal_ureter_morphology0.76194823
117MP0002089_abnormal_postnatal_growth/wei0.75794903
118MP0005187_abnormal_penis_morphology0.73010095
119MP0000689_abnormal_spleen_morphology0.73009799
120MP0000759_abnormal_skeletal_muscle0.72899491
121MP0003221_abnormal_cardiomyocyte_apopto0.72466418
122MP0003315_abnormal_perineum_morphology0.71705377
123MP0003942_abnormal_urinary_system0.70931403
124MP0002098_abnormal_vibrissa_morphology0.69636277
125MP0000858_altered_metastatic_potential0.68956518
126MP0004087_abnormal_muscle_fiber0.68766622
127MP0000467_abnormal_esophagus_morphology0.68766189
128MP0004782_abnormal_surfactant_physiolog0.68594824
129MP0005257_abnormal_intraocular_pressure0.68271221
130MP0000750_abnormal_muscle_regeneration0.67712715

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.64733723
2Ependymoma (HP:0002888)3.41106175
3Cerebral aneurysm (HP:0004944)3.12274522
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.90266259
5Short 4th metacarpal (HP:0010044)2.90266259
6Renal duplication (HP:0000075)2.86310121
7Pseudobulbar signs (HP:0002200)2.86153756
8Astrocytoma (HP:0009592)2.84823236
9Abnormality of the astrocytes (HP:0100707)2.84823236
10Broad face (HP:0000283)2.82644550
11Ulnar bowing (HP:0003031)2.80708543
12Shallow orbits (HP:0000586)2.78112843
13Premature rupture of membranes (HP:0001788)2.70634778
14Distal lower limb amyotrophy (HP:0008944)2.69007411
15Increased nuchal translucency (HP:0010880)2.63627012
16Increased density of long bones (HP:0006392)2.62612734
17Long palpebral fissure (HP:0000637)2.59151981
18Selective tooth agenesis (HP:0001592)2.56941170
19Asymmetry of the thorax (HP:0001555)2.54025228
20Elfin facies (HP:0004428)2.44884470
21Abnormality of the 4th metacarpal (HP:0010012)2.42308485
22Increased connective tissue (HP:0009025)2.42071170
23Renovascular hypertension (HP:0100817)2.39334219
24Insomnia (HP:0100785)2.38754871
25Abnormality of the Achilles tendon (HP:0005109)2.36463024
26Overriding aorta (HP:0002623)2.30896370
27Protrusio acetabuli (HP:0003179)2.29472947
28Flat acetabular roof (HP:0003180)2.28995769
29Deviation of the thumb (HP:0009603)2.28586151
30Obstructive sleep apnea (HP:0002870)2.28454417
31Vertebral compression fractures (HP:0002953)2.28315444
32Basal cell carcinoma (HP:0002671)2.26330953
33Heterotopia (HP:0002282)2.25669578
34Distal upper limb amyotrophy (HP:0007149)2.23297352
35Upper limb amyotrophy (HP:0009129)2.23297352
36Proximal placement of thumb (HP:0009623)2.22692294
37Pointed chin (HP:0000307)2.21781340
38Abnormality of the distal phalanx of the thumb (HP:0009617)2.20675873
39Trismus (HP:0000211)2.19525085
40Genu recurvatum (HP:0002816)2.19180862
41Abnormality of the lower motor neuron (HP:0002366)2.16952001
42Bowel diverticulosis (HP:0005222)2.16403967
43Centrally nucleated skeletal muscle fibers (HP:0003687)2.15598672
44Progressive muscle weakness (HP:0003323)2.15183473
45Dysmetric saccades (HP:0000641)2.14131142
46Hand muscle atrophy (HP:0009130)2.13343606
47Macroorchidism (HP:0000053)2.13221062
48Mitral valve prolapse (HP:0001634)2.12529545
49Malignant gastrointestinal tract tumors (HP:0006749)2.10744632
50Gastrointestinal carcinoma (HP:0002672)2.10744632
51Abnormality of the fingertips (HP:0001211)2.05727179
52High pitched voice (HP:0001620)2.04864119
53Fragile skin (HP:0001030)2.04269168
54Broad distal phalanx of finger (HP:0009836)2.03980081
55Urethral obstruction (HP:0000796)2.03029289
56Subacute progressive viral hepatitis (HP:0006572)2.02877556
57Skin tags (HP:0010609)2.01082631
58Cellulitis (HP:0100658)2.00243289
59Bladder diverticulum (HP:0000015)2.00205237
60Patellar dislocation (HP:0002999)1.99356204
61Broad thumb (HP:0011304)1.97103732
62Sparse lateral eyebrow (HP:0005338)1.96987171
63Fibroma (HP:0010614)1.96792304
64Deep palmar crease (HP:0006191)1.96524182
65Abnormality of oral frenula (HP:0000190)1.96132808
66Glioma (HP:0009733)1.96064657
67Syringomyelia (HP:0003396)1.95625697
68Spinal cord lesions (HP:0100561)1.95625697
69Ankle contracture (HP:0006466)1.94974538
70Rectal prolapse (HP:0002035)1.94958246
71Ankyloglossia (HP:0010296)1.94869478
72Missing ribs (HP:0000921)1.94248210
73Fibrous tissue neoplasm (HP:0012316)1.93362196
74Medulloblastoma (HP:0002885)1.93269394
75Lower limb amyotrophy (HP:0007210)1.91844682
76Neoplasm of striated muscle (HP:0009728)1.90967380
77Hallux valgus (HP:0001822)1.90777656
78Deviation of the hallux (HP:0010051)1.89908797
79Back pain (HP:0003418)1.88326340
80Neoplasm of the oral cavity (HP:0100649)1.88227461
81Abnormality of the thoracic spine (HP:0100711)1.88107544
82Biconcave vertebral bodies (HP:0004586)1.86974272
83Abnormality of the distal phalanges of the toes (HP:0010182)1.86949869
84Mitral regurgitation (HP:0001653)1.86260239
85Aneurysm (HP:0002617)1.84416657
86Long eyelashes (HP:0000527)1.84036114
87Bowed forearm bones (HP:0003956)1.83590058
88Bowing of the arm (HP:0006488)1.83590058
89Angiofibromas (HP:0010615)1.82171861
90Adenoma sebaceum (HP:0009720)1.82171861
91Broad palm (HP:0001169)1.81491098
92Flat cornea (HP:0007720)1.80108754
93Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.79871489
94Spastic diplegia (HP:0001264)1.79592497
95Cholecystitis (HP:0001082)1.79272685
96Abnormal gallbladder physiology (HP:0012438)1.79272685
97Distal lower limb muscle weakness (HP:0009053)1.77745376
98Dislocated radial head (HP:0003083)1.77510893
99Enlarged penis (HP:0000040)1.77434602
100Radial bowing (HP:0002986)1.77015291
101Trigonocephaly (HP:0000243)1.76545547
102Hyperparathyroidism (HP:0000843)1.76095905
103Preauricular skin tag (HP:0000384)1.75415344
104Achilles tendon contracture (HP:0001771)1.75355024
105Dilatation of the ascending aorta (HP:0005111)1.75140916
106Reticulocytosis (HP:0001923)1.73882632
107Progressive external ophthalmoplegia (HP:0000590)1.73650183
108Turricephaly (HP:0000262)1.73365245
109Skull defect (HP:0001362)1.72733150
110Arnold-Chiari malformation (HP:0002308)1.72555928
111Polygenic inheritance (HP:0010982)1.72463493
112Abnormality of the diencephalon (HP:0010662)1.71984909
113Advanced eruption of teeth (HP:0006288)1.71275488
114Volvulus (HP:0002580)1.71058502
115Abnormality of the calcaneus (HP:0008364)1.70778978
116Bicuspid aortic valve (HP:0001647)1.70563402
117Lymphangioma (HP:0100764)1.70226128
118Blue sclerae (HP:0000592)1.69975864
119Premature skin wrinkling (HP:0100678)1.69025659
120Osteolytic defects of the phalanges of the hand (HP:0009771)1.68914737
121Osteolytic defects of the hand bones (HP:0009699)1.68914737
122Short nail (HP:0001799)1.68458930
123Abnormality of the peritoneum (HP:0002585)1.68116206
124Persistence of primary teeth (HP:0006335)1.67728915
125Annular pancreas (HP:0001734)1.67064241
126Difficulty climbing stairs (HP:0003551)1.66902400
127Prominent nose (HP:0000448)1.65712542
128Rhabdomyosarcoma (HP:0002859)1.65628339
129Vertebral arch anomaly (HP:0008438)1.65407717
130Sandal gap (HP:0001852)1.65345465
131Thin ribs (HP:0000883)1.64503184
132Aortic aneurysm (HP:0004942)1.64359517
133Abnormality of the radial head (HP:0003995)1.64327756
134Metaphyseal cupping (HP:0003021)1.64262491
135Rib fusion (HP:0000902)1.64020016
136Hemorrhage of the eye (HP:0011885)1.63743864
137Abnormality of the phalanges of the hallux (HP:0010057)1.62789329
138Disproportionate tall stature (HP:0001519)1.62554591
139Biliary tract neoplasm (HP:0100574)1.62220330
140Colon cancer (HP:0003003)1.61365333
141Termporal pattern (HP:0011008)1.60910213
142Insidious onset (HP:0003587)1.60910213
143Obsessive-compulsive behavior (HP:0000722)1.60601262
144Segmental peripheral demyelination/remyelination (HP:0003481)1.59733387
145Uterine leiomyosarcoma (HP:0002891)1.59159009
146Leiomyosarcoma (HP:0100243)1.59159009
147Short phalanx of the thumb (HP:0009660)1.58777881
148Broad phalanges of the hand (HP:0009768)1.58229497
149Supernumerary ribs (HP:0005815)1.58108200
150Large earlobe (HP:0009748)1.57621167
151Abnormal number of incisors (HP:0011064)1.57579532
152Thin bony cortex (HP:0002753)1.57389061
153Spina bifida occulta (HP:0003298)1.57296298
154Hypopigmentation of the fundus (HP:0007894)1.57199556
155Increased variability in muscle fiber diameter (HP:0003557)1.56660287
156Elbow flexion contracture (HP:0002987)1.56165086
157Abnormal ossification of hand bones (HP:0005921)1.55831023
158Spinal cord compression (HP:0002176)1.55240763
159Germ cell neoplasia (HP:0100728)1.54621637
160Spinal rigidity (HP:0003306)1.54380019
161High anterior hairline (HP:0009890)1.54099174
162Septate vagina (HP:0001153)1.52220206
163Natal tooth (HP:0000695)1.51712396
164Micronodular cirrhosis (HP:0001413)1.51221436
165Generalized amyotrophy (HP:0003700)1.51018544
166Stridor (HP:0010307)1.50930272
167Abnormality of skeletal muscle fiber size (HP:0012084)1.50561745
168Bowel incontinence (HP:0002607)1.49933821

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.63161907
2SMG14.31676441
3TRIB34.27759008
4CDK123.87682673
5PKN23.82146421
6MAP3K103.79806744
7PRPF4B3.31323659
8IRAK32.76203504
9CDC72.31194601
10NEK22.06300129
11NME22.01359169
12ALK1.98383980
13TTN1.93296425
14ICK1.92773295
15PTK61.85867740
16RPS6KB21.85234639
17PDGFRA1.63271664
18STK101.61803676
19RIPK11.59292914
20MAP4K11.55190445
21BMX1.52504768
22LRRK21.51743106
23ERN11.44169093
24PAK41.39239338
25MTOR1.38636431
26CDK41.38521428
27PASK1.34324529
28SCYL21.33623049
29TYRO31.30929485
30SIK21.30430677
31GRK61.28646249
32MAP3K131.27536379
33NEK11.25359935
34CDK61.23234733
35MAP3K81.21348669
36BRD41.19486803
37SIK11.18323854
38TAOK21.16261862
39MST1R1.13525590
40PAK21.11021236
41TTK1.06162920
42LATS11.04820899
43TSSK61.02762044
44CDK70.95973102
45EPHA20.93361105
46CAMK1D0.92591435
47TESK20.91311295
48CHEK10.90518920
49TAOK10.85281559
50CAMK1G0.84733059
51LATS20.84554397
52ARAF0.84304815
53IRAK40.83083910
54IRAK20.81068568
55KSR20.79385083
56DDR20.78468360
57TGFBR10.77288431
58MAP2K20.76870791
59STK30.75049334
60FGFR10.74682911
61PDGFRB0.74535889
62MAP3K90.73329053
63ATR0.73120412
64MAP3K140.72264477
65SIK30.70837337
66RPS6KA40.70525602
67MARK20.69707404
68CDK20.69705474
69MAP3K10.68445943
70STK40.68329596
71BRAF0.67854260
72FLT30.67615953
73ILK0.67393199
74DMPK0.66629332
75RIPK40.66260742
76PRKD20.65547241
77LMTK20.64110278
78PDPK10.64097936
79PRKD30.63779672
80FGFR40.62707533
81TESK10.62403691
82PTK20.62147797
83PIM10.62129052
84RPS6KA20.60391832
85AURKB0.59273373
86RET0.58579581
87MAP3K70.56684880
88AKT20.56282531
89EPHB10.55933724
90MAP3K30.55131845
91NTRK10.54479554
92MAP3K110.53415408
93VRK20.53340201
94AURKA0.53294268
95MAP2K30.52884459
96PLK10.51109073
97RPS6KA10.51065393
98ATM0.51058288
99CSK0.50876301
100FGFR30.49110590
101WEE10.48481830
102CDK80.48285137
103CSF1R0.47996394
104CSNK1D0.47739907
105HCK0.46264987
106CDK90.45830789
107MKNK10.45523634
108ZAP700.45514887
109CHEK20.45208869
110PAK60.44249745
111DYRK1B0.44155443
112BUB10.43538601
113CSNK1E0.43419192
114MELK0.41441237
115CLK10.40971320
116PRKCH0.40654614
117* CDK10.40505157
118BTK0.39527118
119PRKDC0.39026380
120PAK10.38821168
121MAPK110.38752116
122MAPKAPK30.38553207
123TBK10.37280094
124MAPK140.37269947
125ITK0.37064343
126HIPK20.36910251
127JAK30.35554234
128RPS6KC10.35497668
129RPS6KL10.35497668
130CDC42BPA0.34779830
131BRSK10.34039354
132MET0.33274721
133RPS6KA60.32412515
134PRKG20.31532733
135MOS0.30974735

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.21361145
2Chronic myeloid leukemia_Homo sapiens_hsa052202.13880520
3One carbon pool by folate_Homo sapiens_hsa006702.08277779
4mRNA surveillance pathway_Homo sapiens_hsa030152.00334966
5DNA replication_Homo sapiens_hsa030301.95074037
6* Spliceosome_Homo sapiens_hsa030401.94325534
7RNA transport_Homo sapiens_hsa030131.93379412
8mTOR signaling pathway_Homo sapiens_hsa041501.75325802
9Pentose phosphate pathway_Homo sapiens_hsa000301.74461113
10Notch signaling pathway_Homo sapiens_hsa043301.68164602
11MicroRNAs in cancer_Homo sapiens_hsa052061.66285264
12Cell cycle_Homo sapiens_hsa041101.65916490
13Other glycan degradation_Homo sapiens_hsa005111.62207821
14Mismatch repair_Homo sapiens_hsa034301.61029459
15Small cell lung cancer_Homo sapiens_hsa052221.55530044
16Non-small cell lung cancer_Homo sapiens_hsa052231.54067554
17Lysine degradation_Homo sapiens_hsa003101.53812544
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.48810021
19Central carbon metabolism in cancer_Homo sapiens_hsa052301.47543254
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46602445
21Viral carcinogenesis_Homo sapiens_hsa052031.46108315
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.45153064
23Colorectal cancer_Homo sapiens_hsa052101.44456329
24Proteoglycans in cancer_Homo sapiens_hsa052051.41985753
25Prion diseases_Homo sapiens_hsa050201.40512019
26Adherens junction_Homo sapiens_hsa045201.37661579
27Bladder cancer_Homo sapiens_hsa052191.36425426
28B cell receptor signaling pathway_Homo sapiens_hsa046621.36149067
29Endometrial cancer_Homo sapiens_hsa052131.35635557
30Basal cell carcinoma_Homo sapiens_hsa052171.34868393
31HTLV-I infection_Homo sapiens_hsa051661.34467634
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34311040
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33688142
34Acute myeloid leukemia_Homo sapiens_hsa052211.32476127
35Hippo signaling pathway_Homo sapiens_hsa043901.29765038
36Fructose and mannose metabolism_Homo sapiens_hsa000511.29295805
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.21269519
38Pancreatic cancer_Homo sapiens_hsa052121.20952477
39Glioma_Homo sapiens_hsa052141.19704509
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19365630
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.18490617
42VEGF signaling pathway_Homo sapiens_hsa043701.17984371
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17636295
44Base excision repair_Homo sapiens_hsa034101.17066930
45Viral myocarditis_Homo sapiens_hsa054161.15541669
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12895019
47Focal adhesion_Homo sapiens_hsa045101.12688735
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.12125416
49Antigen processing and presentation_Homo sapiens_hsa046121.10031935
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07728584
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06641644
52Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06055698
53Thyroid cancer_Homo sapiens_hsa052161.05352656
54Systemic lupus erythematosus_Homo sapiens_hsa053221.04330896
55Leukocyte transendothelial migration_Homo sapiens_hsa046701.04139975
56Renal cell carcinoma_Homo sapiens_hsa052111.03038709
57T cell receptor signaling pathway_Homo sapiens_hsa046600.99370435
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98206535
59p53 signaling pathway_Homo sapiens_hsa041150.97752295
60Galactose metabolism_Homo sapiens_hsa000520.93861225
61Apoptosis_Homo sapiens_hsa042100.89540406
62Hepatitis B_Homo sapiens_hsa051610.89265620
63HIF-1 signaling pathway_Homo sapiens_hsa040660.87946008
64Estrogen signaling pathway_Homo sapiens_hsa049150.87791131
65Dorso-ventral axis formation_Homo sapiens_hsa043200.87780010
66Hepatitis C_Homo sapiens_hsa051600.86780496
67Prostate cancer_Homo sapiens_hsa052150.86563592
68Hedgehog signaling pathway_Homo sapiens_hsa043400.85331225
69Insulin resistance_Homo sapiens_hsa049310.82654168
70Influenza A_Homo sapiens_hsa051640.82226677
71Pathways in cancer_Homo sapiens_hsa052000.82121716
72Sulfur relay system_Homo sapiens_hsa041220.81510537
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80959866
74Biosynthesis of amino acids_Homo sapiens_hsa012300.80917360
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80325776
76Toxoplasmosis_Homo sapiens_hsa051450.79844044
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79673782
78Primary immunodeficiency_Homo sapiens_hsa053400.78979649
79Herpes simplex infection_Homo sapiens_hsa051680.78970485
80Choline metabolism in cancer_Homo sapiens_hsa052310.78480324
81Tight junction_Homo sapiens_hsa045300.77880321
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.77605219
83Osteoclast differentiation_Homo sapiens_hsa043800.76611413
84TGF-beta signaling pathway_Homo sapiens_hsa043500.76555808
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76183687
86Prolactin signaling pathway_Homo sapiens_hsa049170.76121784
87Nitrogen metabolism_Homo sapiens_hsa009100.74866567
88GnRH signaling pathway_Homo sapiens_hsa049120.73980266
89Carbon metabolism_Homo sapiens_hsa012000.73706969
90AMPK signaling pathway_Homo sapiens_hsa041520.73585669
91Oocyte meiosis_Homo sapiens_hsa041140.73395143
92Inositol phosphate metabolism_Homo sapiens_hsa005620.73121960
93Shigellosis_Homo sapiens_hsa051310.71653534
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70828745
95Insulin signaling pathway_Homo sapiens_hsa049100.70390438
96Platelet activation_Homo sapiens_hsa046110.70336876
97Amoebiasis_Homo sapiens_hsa051460.70064729
98Epstein-Barr virus infection_Homo sapiens_hsa051690.70027056
99Nucleotide excision repair_Homo sapiens_hsa034200.68125608
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66847342
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64925392
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.64479200
103FoxO signaling pathway_Homo sapiens_hsa040680.63494774
104Wnt signaling pathway_Homo sapiens_hsa043100.63479677
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63160713
106ErbB signaling pathway_Homo sapiens_hsa040120.62758126
107Rap1 signaling pathway_Homo sapiens_hsa040150.62165575
108TNF signaling pathway_Homo sapiens_hsa046680.61645701
109Endocytosis_Homo sapiens_hsa041440.59363971
110ECM-receptor interaction_Homo sapiens_hsa045120.58759907
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58407297
112Alcoholism_Homo sapiens_hsa050340.57780541
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.57632163
114Selenocompound metabolism_Homo sapiens_hsa004500.56243206
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55820672
116Type II diabetes mellitus_Homo sapiens_hsa049300.55678714
117N-Glycan biosynthesis_Homo sapiens_hsa005100.54840399
118Leishmaniasis_Homo sapiens_hsa051400.54017554
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53232236
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.52491160
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52387707
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.51962538
123Salmonella infection_Homo sapiens_hsa051320.51624945
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51470237
125Measles_Homo sapiens_hsa051620.51197602
126RNA degradation_Homo sapiens_hsa030180.51113457
127Melanoma_Homo sapiens_hsa052180.49290531
128Vitamin B6 metabolism_Homo sapiens_hsa007500.48670909
129Long-term potentiation_Homo sapiens_hsa047200.47313548

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