UAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.18970128
2Golgi transport vesicle coating (GO:0048200)6.18970128
3vitamin transmembrane transport (GO:0035461)6.15016223
4nuclear pore complex assembly (GO:0051292)5.30964129
5* UDP-N-acetylglucosamine metabolic process (GO:0006047)4.98449209
6folic acid transport (GO:0015884)4.82402194
7purine nucleobase biosynthetic process (GO:0009113)4.65205735
8COPII vesicle coating (GO:0048208)4.60550107
9nuclear pore organization (GO:0006999)4.52310221
10hemidesmosome assembly (GO:0031581)4.47845687
11NIK/NF-kappaB signaling (GO:0038061)4.46888703
12* nucleotide-sugar biosynthetic process (GO:0009226)4.36157841
13folic acid metabolic process (GO:0046655)4.24224746
14biotin metabolic process (GO:0006768)4.17718450
15ribosome assembly (GO:0042255)3.96860839
16pantothenate metabolic process (GO:0015939)3.87169770
17nucleobase biosynthetic process (GO:0046112)3.86795609
18pore complex assembly (GO:0046931)3.81980674
19serine family amino acid catabolic process (GO:0009071)3.78235247
20nucleobase-containing small molecule interconversion (GO:0015949)3.66295620
21mitotic chromosome condensation (GO:0007076)3.65080302
22vesicle coating (GO:0006901)3.64664339
23regulation of RIG-I signaling pathway (GO:0039535)3.54465077
24retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.52343052
25glycine metabolic process (GO:0006544)3.52121483
26modified amino acid transport (GO:0072337)3.47557380
27S-adenosylmethionine metabolic process (GO:0046500)3.47433441
28regulation of spindle organization (GO:0090224)3.39670336
29proline biosynthetic process (GO:0006561)3.38383869
30cell-substrate junction assembly (GO:0007044)3.36208781
31peptidyl-proline hydroxylation (GO:0019511)3.34168002
32homocysteine metabolic process (GO:0050667)3.32919755
33vitamin transport (GO:0051180)3.32549529
34regulation of translational fidelity (GO:0006450)3.31418347
35cysteine metabolic process (GO:0006534)3.29870846
36protein hydroxylation (GO:0018126)3.29661557
37NADH metabolic process (GO:0006734)3.24964604
38urate metabolic process (GO:0046415)3.21744978
39serine family amino acid metabolic process (GO:0009069)3.18662101
40cofactor transport (GO:0051181)3.18349296
41lung-associated mesenchyme development (GO:0060484)3.18153733
42pyrimidine-containing compound transmembrane transport (GO:0072531)3.15844717
43protein maturation by protein folding (GO:0022417)3.14194607
44desmosome organization (GO:0002934)3.13910855
45regulation of plasminogen activation (GO:0010755)3.08122864
46CDP-diacylglycerol metabolic process (GO:0046341)3.04003541
47sulfur amino acid catabolic process (GO:0000098)3.01985207
48mitotic sister chromatid segregation (GO:0000070)3.01715618
49serine family amino acid biosynthetic process (GO:0009070)2.97252947
50fructose metabolic process (GO:0006000)2.95816762
51skeletal muscle tissue regeneration (GO:0043403)2.95415771
52mitotic metaphase plate congression (GO:0007080)2.94987430
53intestinal epithelial cell development (GO:0060576)2.94518107
54iron ion import (GO:0097286)2.93255930
55DNA unwinding involved in DNA replication (GO:0006268)2.91902249
56regulation of metalloenzyme activity (GO:0048552)2.90782674
57protein localization to endosome (GO:0036010)2.89396774
58activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.86521738
59valine metabolic process (GO:0006573)2.86066568
60L-methionine biosynthetic process (GO:0071265)2.85319379
61amino acid salvage (GO:0043102)2.85319379
62L-methionine salvage (GO:0071267)2.85319379
63regulation of mitotic spindle organization (GO:0060236)2.83999167
64positive regulation of nuclease activity (GO:0032075)2.83216593
65mitotic nuclear envelope disassembly (GO:0007077)2.82798538
66histone-serine phosphorylation (GO:0035404)2.82427693
67keratan sulfate catabolic process (GO:0042340)2.80655905
68membrane disassembly (GO:0030397)2.78213634
69nuclear envelope disassembly (GO:0051081)2.78213634
70low-density lipoprotein particle clearance (GO:0034383)2.77097761
71endoplasmic reticulum unfolded protein response (GO:0030968)2.76227873
72interferon-gamma secretion (GO:0072643)2.75992820
73sister chromatid segregation (GO:0000819)2.75896862
74sulfur amino acid biosynthetic process (GO:0000097)2.74605517
75amino-acid betaine metabolic process (GO:0006577)2.73136422
76cellular response to arsenic-containing substance (GO:0071243)2.71844963
77regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.68908906
78regulation of cholesterol homeostasis (GO:2000188)2.68499000
79mitotic nuclear envelope reassembly (GO:0007084)2.67799932
80nuclear envelope reassembly (GO:0031468)2.67799932
81sulfur amino acid metabolic process (GO:0000096)2.67258066
82regulation of early endosome to late endosome transport (GO:2000641)2.66935799
83GMP metabolic process (GO:0046037)2.65081845
84mitotic cytokinesis (GO:0000281)2.63842035
85ER-nucleus signaling pathway (GO:0006984)2.63823767
86negative regulation of anoikis (GO:2000811)2.62988526
87regulation of complement activation (GO:0030449)2.62949729
88blastocyst development (GO:0001824)2.62837712
89cellular protein complex localization (GO:0034629)2.62505179
90regulation of G0 to G1 transition (GO:0070316)2.61501550
91autophagic vacuole assembly (GO:0000045)2.59548555
92focal adhesion assembly (GO:0048041)2.59488323
93cell-substrate adherens junction assembly (GO:0007045)2.59488323
94cellular response to unfolded protein (GO:0034620)2.58574475
95regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.58183513
96positive regulation of Cdc42 GTPase activity (GO:0043089)2.57985975
97sequestering of extracellular ligand from receptor (GO:0035581)2.57916480
98regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.57526317
99regulation of dendritic cell antigen processing and presentation (GO:0002604)2.57466850
100regulation of translational termination (GO:0006449)2.57004138
101skin morphogenesis (GO:0043589)2.55900887
102wound healing, spreading of epidermal cells (GO:0035313)2.55830452
103* nucleotide-sugar metabolic process (GO:0009225)2.54986551
104positive regulation of blood vessel endothelial cell migration (GO:0043536)2.54668079
105regulation of protein activation cascade (GO:2000257)2.54419277
106chondrocyte proliferation (GO:0035988)2.53651574
107endodermal cell differentiation (GO:0035987)2.52696762
1084-hydroxyproline metabolic process (GO:0019471)2.51330246
109regulation of nuclease activity (GO:0032069)2.50617749
110bile acid and bile salt transport (GO:0015721)2.50160367
111negative regulation of lipid storage (GO:0010888)2.49813224
112metaphase plate congression (GO:0051310)2.48882947
113membrane raft organization (GO:0031579)2.48526753
114mesodermal cell differentiation (GO:0048333)2.47793786
115opsonization (GO:0008228)2.47300632
116cell adhesion mediated by integrin (GO:0033627)2.47182197
117kidney mesenchyme development (GO:0072074)2.46950383
118* protein N-linked glycosylation via asparagine (GO:0018279)2.46916174
119deoxyribonucleotide biosynthetic process (GO:0009263)2.46750330
120response to xenobiotic stimulus (GO:0009410)2.45541525
121nuclear envelope organization (GO:0006998)2.45349559
122positive regulation of autophagy (GO:0010508)2.45006298
123maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.44471823
124complement activation, alternative pathway (GO:0006957)2.43896648
125positive regulation of cell size (GO:0045793)2.43670220
126* peptidyl-asparagine modification (GO:0018196)2.43244566
127protein localization to chromosome, centromeric region (GO:0071459)2.42977363
128positive regulation of p38MAPK cascade (GO:1900745)2.42133896
129positive regulation of osteoblast proliferation (GO:0033690)2.41761667
130negative regulation of fatty acid biosynthetic process (GO:0045717)2.41614605
131adherens junction assembly (GO:0034333)2.41114105
132extracellular fibril organization (GO:0043206)2.38151133
133alditol phosphate metabolic process (GO:0052646)2.37834034
134diterpenoid biosynthetic process (GO:0016102)2.37591291
135cytoskeleton-dependent cytokinesis (GO:0061640)2.36969295
136cellular copper ion homeostasis (GO:0006878)2.36790877
137growth hormone receptor signaling pathway (GO:0060396)2.36597767
138cellular response to topologically incorrect protein (GO:0035967)2.34612881
139* protein N-linked glycosylation (GO:0006487)2.34410876
140CDP-diacylglycerol biosynthetic process (GO:0016024)2.33890231
141hyaluronan catabolic process (GO:0030214)2.33472108
142regulation of anoikis (GO:2000209)2.33125372
143establishment of chromosome localization (GO:0051303)2.33004484
144regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.32780445
145apoptotic cell clearance (GO:0043277)2.32364139
146methionine metabolic process (GO:0006555)2.32363156
147ribosome biogenesis (GO:0042254)2.32118525
148branched-chain amino acid metabolic process (GO:0009081)2.32036400
149protein retention in ER lumen (GO:0006621)2.31869516
150hypotonic response (GO:0006971)2.31562063
151regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.31418270
152mammary gland epithelial cell proliferation (GO:0033598)2.31161156
153protein localization to microtubule (GO:0035372)2.31117554
154ventricular cardiac muscle cell development (GO:0055015)2.31098101
155response to unfolded protein (GO:0006986)2.31043553
156negative regulation of innate immune response (GO:0045824)2.30489759
157intestinal cholesterol absorption (GO:0030299)2.29452294
158endothelial cell morphogenesis (GO:0001886)2.29402894
159methionine biosynthetic process (GO:0009086)2.29185713
160L-serine metabolic process (GO:0006563)2.28591693
161collagen fibril organization (GO:0030199)2.28288987
162retina vasculature morphogenesis in camera-type eye (GO:0061299)2.27799751
163branched-chain amino acid catabolic process (GO:0009083)2.27134366
164regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.26829295
165protein export from nucleus (GO:0006611)2.26416215
166regulation of transforming growth factor beta1 production (GO:0032908)2.26354567
167water-soluble vitamin metabolic process (GO:0006767)2.25952935
168type B pancreatic cell proliferation (GO:0044342)2.25843717
169formation of translation preinitiation complex (GO:0001731)2.25164888
170cellular response to vitamin (GO:0071295)2.23951624
171negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.23069087
172dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.22642796
173glutamine family amino acid biosynthetic process (GO:0009084)2.22275048
174regulation of sequestering of triglyceride (GO:0010889)2.21988812
175negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.21479283
176epithelial cell-cell adhesion (GO:0090136)2.21471746
177regulation of response to interferon-gamma (GO:0060330)2.20480401
178nucleoside diphosphate biosynthetic process (GO:0009133)2.19858109
179response to hydroperoxide (GO:0033194)2.19431360
180rRNA modification (GO:0000154)2.18221336
181regulation of integrin-mediated signaling pathway (GO:2001044)2.17443559

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.33749268
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.80783078
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.65303193
4CLOCK_20551151_ChIP-Seq_293T_Human2.96714749
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.96141970
6ZNF263_19887448_ChIP-Seq_K562_Human2.89762494
7* RXR_22158963_ChIP-Seq_LIVER_Mouse2.81331175
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.72756992
9AR_21909140_ChIP-Seq_LNCAP_Human2.67331322
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.53391968
11STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.46926448
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.36163013
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.34537773
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.33580964
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.24818314
16E2F7_22180533_ChIP-Seq_HELA_Human2.15317116
17LXR_22158963_ChIP-Seq_LIVER_Mouse2.10667792
18PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.06586970
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.98914090
20STAT3_1855785_ChIP-Seq_MESCs_Mouse1.98550928
21WT1_19549856_ChIP-ChIP_CCG9911_Human1.93787229
22* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.91359618
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88099144
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.86120810
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85056995
26GATA1_22025678_ChIP-Seq_K562_Human1.81986414
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79894228
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.73677904
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.73421305
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71379791
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.71055394
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.68310934
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67816105
34SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.65923698
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.65754992
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.65621487
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65209920
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.64415664
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.63878319
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.62371793
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61826277
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.60301833
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.59214341
44SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.58621872
45P300_27058665_Chip-Seq_ZR-75-30cells_Human1.57417135
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56672032
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.55089812
48* BRD4_25478319_ChIP-Seq_HGPS_Human1.54566776
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.52464490
50ATF3_27146783_Chip-Seq_COLON_Human1.50432241
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49052643
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45979743
53* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.43037994
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42566559
55* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.42398280
56* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41218793
57* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.40563823
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40512789
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38928013
60* CHD1_26751641_Chip-Seq_LNCaP_Human1.38842775
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36242296
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35763952
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.35342312
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.32682553
65* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31275580
66GATA4_25053715_ChIP-Seq_YYC3_Human1.30827700
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30457434
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.27913486
69IRF8_22096565_ChIP-ChIP_GC-B_Human1.25751034
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25515821
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24832619
72TFEB_21752829_ChIP-Seq_HELA_Human1.23891348
73* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22220468
74* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22220468
75SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21382409
76ELK1_19687146_ChIP-ChIP_HELA_Human1.21217863
77CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19179779
78MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18715985
79CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.18710541
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.18357077
81* SOX17_20123909_ChIP-Seq_XEN_Mouse1.17942782
82* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17713926
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.16266714
84* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15895338
85TTF2_22483619_ChIP-Seq_HELA_Human1.12371936
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11858391
87FOXO3_23340844_ChIP-Seq_DLD1_Human1.11365449
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.11106145
89ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.10753431
90EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10420136
91E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10061373
92DCP1A_22483619_ChIP-Seq_HELA_Human1.09685276
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09614020
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09360514
95* CJUN_26792858_Chip-Seq_BT549_Human1.09278651
96VDR_23849224_ChIP-Seq_CD4+_Human1.08971631
97PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.08649718
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07438106
99TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07007881
100UBF1/2_26484160_Chip-Seq_HMECs_Human1.06026844
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05598031
102THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05179592
103TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04839317
104MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04617819
105TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.03629250
106* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03008530
107POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02602779
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02368709
109MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01993534
110SOX2_20726797_ChIP-Seq_SW620_Human1.01349523
111KAP1_22055183_ChIP-Seq_ESCs_Mouse1.01099084
112IRF8_21731497_ChIP-ChIP_J774_Mouse1.00616019
113GATA6_25053715_ChIP-Seq_YYC3_Human1.00569611
114* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98082720
115TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.95733868
116KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95280550
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95170025
118* RACK7_27058665_Chip-Seq_MCF-7_Human0.94694331
119NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94686535
120NCOR1_26117541_ChIP-Seq_K562_Human0.94627289
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93771035
122GABP_19822575_ChIP-Seq_HepG2_Human0.91966307
123JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91864113
124FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.91664644
125FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91581441
126RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91168307
127JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90216776
128PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89472576
129EST1_17652178_ChIP-ChIP_JURKAT_Human0.88411303
130HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88318016
131NOTCH1_21737748_ChIP-Seq_TLL_Human0.86240770
132NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.86185275
133* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.85925025
134XRN2_22483619_ChIP-Seq_HELA_Human0.82323940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.07692031
2MP0002138_abnormal_hepatobiliary_system3.35740529
3MP0005275_abnormal_skin_tensile3.19789005
4MP0003950_abnormal_plasma_membrane3.18190241
5MP0009840_abnormal_foam_cell2.97703786
6MP0002254_reproductive_system_inflammat2.83843560
7MP0003705_abnormal_hypodermis_morpholog2.76483754
8MP0005503_abnormal_tendon_morphology2.69169730
9MP0010352_gastrointestinal_tract_polyps2.50017742
10MP0003941_abnormal_skin_development2.48549784
11MP0005623_abnormal_meninges_morphology2.46016061
12MP0002139_abnormal_hepatobiliary_system2.42568553
13MP0002877_abnormal_melanocyte_morpholog2.24056353
14MP0005360_urolithiasis2.20372675
15MP0003693_abnormal_embryo_hatching2.12686978
16MP0001542_abnormal_bone_strength2.05201638
17MP0005365_abnormal_bile_salt1.99590089
18MP0005085_abnormal_gallbladder_physiolo1.96695794
19MP0010368_abnormal_lymphatic_system1.90887591
20MP0009697_abnormal_copulation1.87736166
21MP0003806_abnormal_nucleotide_metabolis1.84296886
22MP0003718_maternal_effect1.78521616
23MP0004233_abnormal_muscle_weight1.78307418
24MP0001958_emphysema1.77901417
25MP0008260_abnormal_autophagy1.66008015
26MP0008932_abnormal_embryonic_tissue1.57222396
27MP0002060_abnormal_skin_morphology1.56687702
28MP0009780_abnormal_chondrocyte_physiolo1.54631619
29MP0003724_increased_susceptibility_to1.51156713
30MP0003091_abnormal_cell_migration1.49049345
31MP0008007_abnormal_cellular_replicative1.48273353
32MP0005451_abnormal_body_composition1.47289470
33MP0003279_aneurysm1.44715027
34MP0005332_abnormal_amino_acid1.44464879
35MP0004185_abnormal_adipocyte_glucose1.44169223
36MP0002009_preneoplasia1.41940015
37MP0009384_cardiac_valve_regurgitation1.41217075
38MP0001661_extended_life_span1.40478697
39MP0004858_abnormal_nervous_system1.39232125
40MP0005670_abnormal_white_adipose1.37870145
41MP0000609_abnormal_liver_physiology1.37566679
42MP0010030_abnormal_orbit_morphology1.36189149
43MP0001666_abnormal_nutrient_absorption1.35777219
44MP0003191_abnormal_cellular_cholesterol1.34308200
45MP0004019_abnormal_vitamin_homeostasis1.32739261
46MP0000733_abnormal_muscle_development1.31108164
47MP0000762_abnormal_tongue_morphology1.28741856
48MP0005023_abnormal_wound_healing1.26706189
49MP0002166_altered_tumor_susceptibility1.25484461
50MP0002876_abnormal_thyroid_physiology1.25243606
51MP0005666_abnormal_adipose_tissue1.25081434
52MP0001348_abnormal_lacrimal_gland1.24951719
53MP0000685_abnormal_immune_system1.23189027
54MP0006054_spinal_hemorrhage1.20621390
55MP0003656_abnormal_erythrocyte_physiolo1.19882531
56MP0009053_abnormal_anal_canal1.18198122
57MP0003077_abnormal_cell_cycle1.17618227
58MP0005501_abnormal_skin_physiology1.16916964
59MP0003566_abnormal_cell_adhesion1.16857410
60MP0003453_abnormal_keratinocyte_physiol1.16235718
61MP0001756_abnormal_urination1.15264623
62MP0001730_embryonic_growth_arrest1.14912625
63MP0002896_abnormal_bone_mineralization1.14786933
64MP0008875_abnormal_xenobiotic_pharmacok1.13919173
65MP0010329_abnormal_lipoprotein_level1.13764583
66MP0005377_hearing/vestibular/ear_phenot1.12845413
67MP0003878_abnormal_ear_physiology1.12845413
68MP0001243_abnormal_dermal_layer1.12237629
69MP0000678_abnormal_parathyroid_gland1.11413536
70MP0000003_abnormal_adipose_tissue1.10921691
71MP0009643_abnormal_urine_homeostasis1.10499426
72MP0000750_abnormal_muscle_regeneration1.10462182
73MP0003868_abnormal_feces_composition1.09815737
74MP0000467_abnormal_esophagus_morphology1.09122020
75MP0000751_myopathy1.08296276
76MP0001873_stomach_inflammation1.08013094
77MP0001299_abnormal_eye_distance/1.07974178
78MP0000350_abnormal_cell_proliferation1.04764581
79MP0005319_abnormal_enzyme/_coenzyme1.04338356
80MP0003186_abnormal_redox_activity1.04096713
81MP0002796_impaired_skin_barrier1.03531656
82MP0000537_abnormal_urethra_morphology1.03109678
83MP0001533_abnormal_skeleton_physiology1.02972820
84MP0003252_abnormal_bile_duct1.02615340
85MP0001764_abnormal_homeostasis1.01529843
86MP0003786_premature_aging1.01413084
87MP0005395_other_phenotype0.99599661
88MP0005058_abnormal_lysosome_morphology0.99058415
89MP0005076_abnormal_cell_differentiation0.98129702
90MP0005330_cardiomyopathy0.97730721
91MP0005508_abnormal_skeleton_morphology0.97471682
92MP0000749_muscle_degeneration0.96419373
93MP0001545_abnormal_hematopoietic_system0.95882502
94MP0005397_hematopoietic_system_phenotyp0.95882502
95MP0003385_abnormal_body_wall0.95407328
96MP0001216_abnormal_epidermal_layer0.95372697
97MP0000759_abnormal_skeletal_muscle0.95335048
98MP0002396_abnormal_hematopoietic_system0.93731908
99MP0002118_abnormal_lipid_homeostasis0.93636298
100MP0000767_abnormal_smooth_muscle0.92304507
101MP0002295_abnormal_pulmonary_circulatio0.92002326
102MP0000747_muscle_weakness0.91913187
103MP0004947_skin_inflammation0.91818152
104MP0005390_skeleton_phenotype0.90921860
105MP0010094_abnormal_chromosome_stability0.90016884
106MP0004957_abnormal_blastocyst_morpholog0.89503970
107MP0003111_abnormal_nucleus_morphology0.88903546
108MP0002086_abnormal_extraembryonic_tissu0.88491342
109MP0002006_tumorigenesis0.88377007
110MP0002080_prenatal_lethality0.87982980
111MP0002971_abnormal_brown_adipose0.87799685
112MP0009333_abnormal_splenocyte_physiolog0.87020605
113MP0010234_abnormal_vibrissa_follicle0.87014153
114MP0001881_abnormal_mammary_gland0.85621349
115MP0001879_abnormal_lymphatic_vessel0.85111903
116MP0002269_muscular_atrophy0.85071847
117MP0005621_abnormal_cell_physiology0.84603876
118MP0005380_embryogenesis_phenotype0.83843562
119MP0001672_abnormal_embryogenesis/_devel0.83843562
120MP0005375_adipose_tissue_phenotype0.82974200
121MP0004134_abnormal_chest_morphology0.82915716
122MP0004272_abnormal_basement_membrane0.82768533
123MP0000627_abnormal_mammary_gland0.82580699
124MP0001915_intracranial_hemorrhage0.81880741
125MP0003436_decreased_susceptibility_to0.81453009
126MP0003984_embryonic_growth_retardation0.80926119
127MP0002933_joint_inflammation0.79867734
128MP0001697_abnormal_embryo_size0.79541562
129MP0000858_altered_metastatic_potential0.78513870
130MP0003448_altered_tumor_morphology0.78195146
131MP0000013_abnormal_adipose_tissue0.77809236
132MP0002088_abnormal_embryonic_growth/wei0.77155434
133MP0000358_abnormal_cell_content/0.76980088
134MP0002084_abnormal_developmental_patter0.76315863
135MP0008004_abnormal_stomach_pH0.76188438
136MP0010307_abnormal_tumor_latency0.76153567
137MP0001849_ear_inflammation0.76138785
138MP0002136_abnormal_kidney_physiology0.75964152
139MP0004084_abnormal_cardiac_muscle0.75639719
140MP0005408_hypopigmentation0.75534930
141MP0000377_abnormal_hair_follicle0.74934927
142MP0000534_abnormal_ureter_morphology0.74908438
143MP0010771_integument_phenotype0.74857388
144MP0003221_abnormal_cardiomyocyte_apopto0.74685623
145MP0008469_abnormal_protein_level0.74000747
146MP0010155_abnormal_intestine_physiology0.73875985
147MP0001346_abnormal_lacrimal_gland0.73844520
148MP0004087_abnormal_muscle_fiber0.73831279
149MP0009250_abnormal_appendicular_skeleto0.73723883
150MP0004264_abnormal_extraembryonic_tissu0.72974072
151MP0002234_abnormal_pharynx_morphology0.72911742
152MP0003195_calcinosis0.72654402
153MP0005257_abnormal_intraocular_pressure0.71470807
154MP0002108_abnormal_muscle_morphology0.70842199
155MP0006138_congestive_heart_failure0.69768244
156MP0000598_abnormal_liver_morphology0.69577260
157MP0005084_abnormal_gallbladder_morpholo0.69321736
158MP0003828_pulmonary_edema0.68575556

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.99322418
2Hyperglycinemia (HP:0002154)4.28424433
3Hyperglycinuria (HP:0003108)4.23169718
4Osteolytic defects of the hand bones (HP:0009699)3.89910982
5Osteolytic defects of the phalanges of the hand (HP:0009771)3.89910982
6Gout (HP:0001997)3.77666572
7Abnormality of serine family amino acid metabolism (HP:0010894)3.74828448
8Abnormality of glycine metabolism (HP:0010895)3.74828448
9Abnormality of the distal phalanges of the toes (HP:0010182)3.65161381
10Protrusio acetabuli (HP:0003179)3.34739349
11Muscle fiber splitting (HP:0003555)3.24833968
12Cervical subluxation (HP:0003308)3.23723682
13Aortic dissection (HP:0002647)3.16302925
14Short nail (HP:0001799)3.15509142
15Ureteral duplication (HP:0000073)3.14297405
16Ankle contracture (HP:0006466)3.09556125
17Follicular hyperkeratosis (HP:0007502)2.98604368
18Pustule (HP:0200039)2.98258102
19Vascular tortuosity (HP:0004948)2.97910537
20Entropion (HP:0000621)2.87249335
21Myocardial infarction (HP:0001658)2.83775563
22Patent foramen ovale (HP:0001655)2.83475152
23Ankyloglossia (HP:0010296)2.79454843
24Stillbirth (HP:0003826)2.79307143
25Arterial tortuosity (HP:0005116)2.79216045
26Alopecia of scalp (HP:0002293)2.77721598
27Abnormality of the umbilical cord (HP:0010881)2.75722307
28Elbow flexion contracture (HP:0002987)2.69674643
29Xanthomatosis (HP:0000991)2.68813387
30Abnormal delivery (HP:0001787)2.67723252
31Bladder diverticulum (HP:0000015)2.66285643
32Abnormality of dentin (HP:0010299)2.66021604
33Wrist flexion contracture (HP:0001239)2.65727662
34Aortic aneurysm (HP:0004942)2.62832132
35Increased connective tissue (HP:0009025)2.60206507
36Polycythemia (HP:0001901)2.58402267
37Reduced subcutaneous adipose tissue (HP:0003758)2.57039238
38Abnormality of serum amino acid levels (HP:0003112)2.55557103
39Achilles tendon contracture (HP:0001771)2.55195831
40Hyperglycemia (HP:0003074)2.53844150
41Cardiovascular calcification (HP:0011915)2.51172140
42Mitral stenosis (HP:0001718)2.45253438
43Increased purine levels (HP:0004368)2.44730289
44Hyperuricemia (HP:0002149)2.44730289
45Abnormal cartilage morphology (HP:0002763)2.44043067
46Carpal bone hypoplasia (HP:0001498)2.43876321
47Peritonitis (HP:0002586)2.43216068
48Rough bone trabeculation (HP:0100670)2.42861756
49Glucose intolerance (HP:0000833)2.40574352
50Abnormality of oral frenula (HP:0000190)2.39140577
51Abnormality of carpal bone ossification (HP:0006257)2.38647205
52Soft skin (HP:0000977)2.36105746
53Irregular epiphyses (HP:0010582)2.34258454
54Blue sclerae (HP:0000592)2.33262551
55Abnormality of the Achilles tendon (HP:0005109)2.32447578
56Mildly elevated creatine phosphokinase (HP:0008180)2.31176545
57Segmental peripheral demyelination/remyelination (HP:0003481)2.29832584
58Ileus (HP:0002595)2.28592711
59Abnormality of purine metabolism (HP:0004352)2.27887193
60Upper limb amyotrophy (HP:0009129)2.25684473
61Distal upper limb amyotrophy (HP:0007149)2.25684473
62Abnormality of the proximal phalanges of the hand (HP:0009834)2.22475149
63Distal lower limb amyotrophy (HP:0008944)2.22262374
64Abnormality of fatty-acid metabolism (HP:0004359)2.21797864
65Onycholysis (HP:0001806)2.21260614
66Type 1 muscle fiber predominance (HP:0003803)2.19892477
67Breech presentation (HP:0001623)2.19490096
68Delayed epiphyseal ossification (HP:0002663)2.18637602
69Spinal cord compression (HP:0002176)2.16725854
70Abnormality of subcutaneous fat tissue (HP:0001001)2.14604103
71Abnormal trabecular bone morphology (HP:0100671)2.13854948
72Difficulty climbing stairs (HP:0003551)2.11758863
73Progressive muscle weakness (HP:0003323)2.10903645
74Atrioventricular block (HP:0001678)2.09640771
75Dilatation of the ascending aorta (HP:0005111)2.08971313
76Nonimmune hydrops fetalis (HP:0001790)2.08679536
77Relative macrocephaly (HP:0004482)2.08057460
78Trismus (HP:0000211)2.07846270
79Abnormal gallbladder physiology (HP:0012438)2.07605733
80Cholecystitis (HP:0001082)2.07605733
81Hyperammonemia (HP:0001987)2.06148221
82Abnormality of the tricuspid valve (HP:0001702)2.05517044
83Back pain (HP:0003418)2.05220796
84Areflexia of lower limbs (HP:0002522)2.05205565
85Congenital, generalized hypertrichosis (HP:0004540)2.05047780
86Abnormal ossification of hand bones (HP:0005921)2.05046678
87Generalized amyotrophy (HP:0003700)2.03647550
88Hyperextensible skin (HP:0000974)2.03399355
89Cupped ribs (HP:0000887)2.03118568
90Vertebral compression fractures (HP:0002953)2.02752344
91Termporal pattern (HP:0011008)2.02037628
92Insidious onset (HP:0003587)2.02037628
93Abnormal tarsal ossification (HP:0008369)2.01689957
94Beaking of vertebral bodies (HP:0004568)2.01621055
95Abnormality of proline metabolism (HP:0010907)1.99933283
96Hydroxyprolinuria (HP:0003080)1.99933283
97Abnormality of glutamine family amino acid metabolism (HP:0010902)1.99600944
98Decreased subcutaneous fat (HP:0001002)1.99347797
99Abnormality of the intrinsic pathway (HP:0010989)1.99266546
100Flat capital femoral epiphysis (HP:0003370)1.98818044
101Fatigue (HP:0012378)1.98675981
102Syringomyelia (HP:0003396)1.96984348
103Spinal cord lesions (HP:0100561)1.96984348
104Insulin-resistant diabetes mellitus (HP:0000831)1.96423408
105Complement deficiency (HP:0004431)1.95011205
106Disproportionate tall stature (HP:0001519)1.94845941
107Flat acetabular roof (HP:0003180)1.93019187
108Upper limb muscle weakness (HP:0003484)1.93008917
109Joint laxity (HP:0001388)1.92660410
110Submucous cleft hard palate (HP:0000176)1.91733727
111Hypoalphalipoproteinemia (HP:0003233)1.91719354
112Hand muscle atrophy (HP:0009130)1.90692465
113Orthostatic hypotension (HP:0001278)1.89714407
114Mitral valve prolapse (HP:0001634)1.89527831
115Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88985249
116Dicarboxylic aciduria (HP:0003215)1.88985249
117Abnormalities of placenta or umbilical cord (HP:0001194)1.88707439
118Neonatal short-limb short stature (HP:0008921)1.88620854
119Atrophic scars (HP:0001075)1.88269291
120Vascular calcification (HP:0004934)1.88182113
121Natal tooth (HP:0000695)1.87269273
122Abnormality of glycolysis (HP:0004366)1.86946051
123Limb-girdle muscle atrophy (HP:0003797)1.85824538
124Multiple enchondromatosis (HP:0005701)1.85651371
125Toxemia of pregnancy (HP:0100603)1.84671903
126Shallow orbits (HP:0000586)1.84375256
127Abnormality of monocarboxylic acid metabolism (HP:0010996)1.84292101
128Death in infancy (HP:0001522)1.84256064
129Biconcave vertebral bodies (HP:0004586)1.84128393
130Right ventricular cardiomyopathy (HP:0011663)1.82603960
131Thick nail (HP:0001805)1.82254556
132Knee flexion contracture (HP:0006380)1.81687078
133Breast hypoplasia (HP:0003187)1.81311546
134Ulnar bowing (HP:0003031)1.80621057
135Intrahepatic cholestasis (HP:0001406)1.80235108
136Abnormality of complement system (HP:0005339)1.79449220
137Increased serum pyruvate (HP:0003542)1.79026396
138Abnormality of nucleobase metabolism (HP:0010932)1.76993025
139Abnormal foot bone ossification (HP:0010675)1.76807198
140Fragile skin (HP:0001030)1.76560643
141Limb-girdle muscle weakness (HP:0003325)1.75788958
142Distal lower limb muscle weakness (HP:0009053)1.75456537
143Small epiphyses (HP:0010585)1.74123990
144Spinal rigidity (HP:0003306)1.73862731
145Microglossia (HP:0000171)1.73809938
146Joint stiffness (HP:0001387)1.73659818
147Sparse lateral eyebrow (HP:0005338)1.72220731
148Chondrocalcinosis (HP:0000934)1.71708729
149Mitral regurgitation (HP:0001653)1.70734281
150Thoracolumbar scoliosis (HP:0002944)1.70558923
151Genu recurvatum (HP:0002816)1.70261206
152Abnormality of aromatic amino acid family metabolism (HP:0004338)1.69088525
153Hypolipoproteinemia (HP:0010981)1.68078236
154Thin skin (HP:0000963)1.68047465
155Wormian bones (HP:0002645)1.67943600
156Redundant skin (HP:0001582)1.67279456
157Abnormality of transition element cation homeostasis (HP:0011030)1.66372493
158Azoospermia (HP:0000027)1.66069506
159Abnormality of the acetabulum (HP:0003170)1.65868322
160Birth length less than 3rd percentile (HP:0003561)1.65756736
161Abnormality of the phalanges of the hallux (HP:0010057)1.65470616
162Pterygium (HP:0001059)1.64902688
163Abnormal hand bone ossification (HP:0010660)1.64247957
164Tetraparesis (HP:0002273)1.63814121
165Abnormality of the fetal cardiovascular system (HP:0010948)1.62290869
166Abnormal umbilical cord blood vessels (HP:0011403)1.62290869
167Single umbilical artery (HP:0001195)1.62290869
168Venous abnormality (HP:0002624)1.62248041
169Shoulder girdle muscle weakness (HP:0003547)1.61808190
170Coronal craniosynostosis (HP:0004440)1.61653917
171Congenital glaucoma (HP:0001087)1.61202269
172Aortic regurgitation (HP:0001659)1.60518488
173Delayed cranial suture closure (HP:0000270)1.60469886

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.99453623
2WEE13.52327544
3PLK42.84997018
4MAP3K32.65659001
5EPHA22.60947903
6PBK2.50535490
7PIM22.49127141
8STK32.43217046
9ACVR1B2.30691498
10PAK42.21761224
11EIF2AK12.12282892
12PTK22.09081212
13NME22.08462960
14EIF2AK32.05492026
15TSSK61.99235439
16BCKDK1.94626166
17MAP3K141.90732477
18BRSK21.84583082
19MST1R1.78930720
20NTRK11.78139032
21FGFR41.77302236
22NEK21.76236365
23ERBB41.73680647
24TYK21.70291288
25EPHB11.64788467
26ICK1.59905546
27ARAF1.56611326
28TESK11.55777973
29EEF2K1.53169025
30KSR21.52554086
31PDK31.52287493
32PDK41.52287493
33IKBKB1.49450611
34MYLK1.47580998
35PDK21.47256108
36STK241.41148094
37MOS1.37242005
38EPHA31.35808878
39DDR21.34974377
40NEK91.32221521
41FRK1.31320753
42PLK31.27084211
43MAP2K21.25231468
44TRIB31.22289742
45DYRK31.22268854
46SRPK11.19865514
47ERN11.16397605
48NEK11.16336005
49MAP3K121.15926900
50RPS6KA41.15522426
51LMTK21.14135584
52CLK11.11676737
53LATS21.09949397
54AKT31.08188648
55LIMK11.07045789
56IRAK31.04814440
57EPHB21.02643784
58PLK11.00572088
59KSR11.00328823
60MAP2K30.99754741
61TRPM70.99278455
62STK38L0.99049973
63CDK120.96372566
64MAP3K80.95167866
65ZAK0.94042587
66ABL20.92817869
67PRKAA20.92671928
68TTN0.91772451
69MET0.91492874
70TIE10.91448123
71ILK0.90424998
72STK100.90311867
73JAK30.88113451
74TTK0.85832966
75MAP2K10.84574005
76SMG10.82345960
77CCNB10.81163297
78MAP3K60.79292538
79TAOK20.79143955
80TGFBR20.79031702
81GSK3A0.76317733
82CDK80.75887016
83STK380.75807001
84MELK0.75519369
85CHUK0.73693216
86EIF2AK20.72182235
87PRKAA10.71276776
88PIM10.71266098
89MTOR0.69300776
90VRK10.67396149
91JAK10.67392332
92BCR0.66237356
93JAK20.64042303
94TGFBR10.63364159
95ERBB30.62909408
96BMPR1B0.62855498
97SCYL20.62164189
98MST40.61008048
99CDK70.60881232
100DMPK0.60579462
101AURKB0.58466773
102PINK10.58346540
103SIK10.57487104
104PRKD30.57395586
105PRKCI0.57086603
106CDC70.56909167
107BMX0.55149976
108PAK10.54727992
109FER0.54165612
110FLT30.53906525
111ALK0.53447632
112PKN20.52021605
113ZAP700.52013908
114PTK60.51501388
115LRRK20.51041168
116PNCK0.51014908
117NUAK10.50113920
118CHEK10.49489611
119RAF10.49473606
120CHEK20.48951986
121BMPR20.48930966
122RIPK10.48922382
123PAK20.48575074
124TBK10.47774820
125PRPF4B0.47554057
126NLK0.46658803
127MAPKAPK20.46452391
128TESK20.45139717
129STK160.44439386
130PIK3CA0.43284001
131NME10.43236422
132PDGFRB0.42301075
133AKT20.41911441
134BRSK10.41641780
135STK40.41167659
136MAP3K20.40280426
137PRKG20.40170383
138CSF1R0.38955038
139RPS6KB20.38135808
140PTK2B0.37745290
141RPS6KA50.36996597
142BRAF0.34457742
143LATS10.32963835
144CDK60.32378029
145CDK40.32208856
146AURKA0.31915259
147PDGFRA0.31304250

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.87959356
2Folate biosynthesis_Homo sapiens_hsa007902.78960845
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.49276085
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45126754
5Vitamin digestion and absorption_Homo sapiens_hsa049772.43205423
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.42027281
7Pentose phosphate pathway_Homo sapiens_hsa000302.02785819
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00709852
9Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.98446994
10* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.95961515
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.87414629
12Sulfur metabolism_Homo sapiens_hsa009201.83808011
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72488024
14Proteasome_Homo sapiens_hsa030501.70185800
15RNA polymerase_Homo sapiens_hsa030201.68609139
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.68089982
17Drug metabolism - other enzymes_Homo sapiens_hsa009831.65094598
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.64900792
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.62651189
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61850531
21Focal adhesion_Homo sapiens_hsa045101.61846761
22Caffeine metabolism_Homo sapiens_hsa002321.59128519
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.56826152
24Regulation of autophagy_Homo sapiens_hsa041401.54870704
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54236323
26Propanoate metabolism_Homo sapiens_hsa006401.50804469
27Bladder cancer_Homo sapiens_hsa052191.50224003
28N-Glycan biosynthesis_Homo sapiens_hsa005101.48818325
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.46393421
30p53 signaling pathway_Homo sapiens_hsa041151.46059275
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44707258
32Nucleotide excision repair_Homo sapiens_hsa034201.42497979
33Arginine biosynthesis_Homo sapiens_hsa002201.38054103
34Adherens junction_Homo sapiens_hsa045201.36889881
35Fructose and mannose metabolism_Homo sapiens_hsa000511.36678669
36Histidine metabolism_Homo sapiens_hsa003401.36231063
37Thyroid cancer_Homo sapiens_hsa052161.34905429
38Fatty acid degradation_Homo sapiens_hsa000711.34133975
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.32856493
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.31297074
41Proteoglycans in cancer_Homo sapiens_hsa052051.30680819
42Biosynthesis of amino acids_Homo sapiens_hsa012301.29855985
43Carbon metabolism_Homo sapiens_hsa012001.28781991
44Prion diseases_Homo sapiens_hsa050201.24788619
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.24709673
46Chronic myeloid leukemia_Homo sapiens_hsa052201.23867388
47beta-Alanine metabolism_Homo sapiens_hsa004101.22658247
48Mismatch repair_Homo sapiens_hsa034301.19683571
49Central carbon metabolism in cancer_Homo sapiens_hsa052301.17143162
50Fat digestion and absorption_Homo sapiens_hsa049751.16198082
51Butanoate metabolism_Homo sapiens_hsa006501.14708720
52Phenylalanine metabolism_Homo sapiens_hsa003601.13850792
53Tryptophan metabolism_Homo sapiens_hsa003801.12933134
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11934518
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08302890
56PPAR signaling pathway_Homo sapiens_hsa033201.07820645
57Glutathione metabolism_Homo sapiens_hsa004801.06401074
58Sulfur relay system_Homo sapiens_hsa041221.05217456
59Starch and sucrose metabolism_Homo sapiens_hsa005001.03514338
60Complement and coagulation cascades_Homo sapiens_hsa046101.03195065
61Selenocompound metabolism_Homo sapiens_hsa004501.02260425
62Small cell lung cancer_Homo sapiens_hsa052220.98337652
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97475923
64Vibrio cholerae infection_Homo sapiens_hsa051100.96942123
65Arginine and proline metabolism_Homo sapiens_hsa003300.96304574
66Pancreatic cancer_Homo sapiens_hsa052120.96087918
67Shigellosis_Homo sapiens_hsa051310.94151177
68MicroRNAs in cancer_Homo sapiens_hsa052060.92726072
69Linoleic acid metabolism_Homo sapiens_hsa005910.90241440
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.88829611
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88298069
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88216769
73Protein digestion and absorption_Homo sapiens_hsa049740.88150165
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86993525
75Arachidonic acid metabolism_Homo sapiens_hsa005900.86932586
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86543876
77Pyrimidine metabolism_Homo sapiens_hsa002400.85109970
78Glycerolipid metabolism_Homo sapiens_hsa005610.84261097
79ECM-receptor interaction_Homo sapiens_hsa045120.83156340
80Legionellosis_Homo sapiens_hsa051340.83033437
81RNA transport_Homo sapiens_hsa030130.82647450
82Peroxisome_Homo sapiens_hsa041460.81588018
83Fatty acid metabolism_Homo sapiens_hsa012120.80871455
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79580224
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77920667
86Cell cycle_Homo sapiens_hsa041100.76539479
87Antigen processing and presentation_Homo sapiens_hsa046120.76193107
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75602274
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75582631
90TGF-beta signaling pathway_Homo sapiens_hsa043500.75523991
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74411685
92Staphylococcus aureus infection_Homo sapiens_hsa051500.74392372
93Retinol metabolism_Homo sapiens_hsa008300.73597754
94Fatty acid biosynthesis_Homo sapiens_hsa000610.72993364
95Renal cell carcinoma_Homo sapiens_hsa052110.72593316
96Chemical carcinogenesis_Homo sapiens_hsa052040.71673802
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70950148
98Steroid biosynthesis_Homo sapiens_hsa001000.70788204
99Apoptosis_Homo sapiens_hsa042100.70411806
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69985453
101Other glycan degradation_Homo sapiens_hsa005110.68776914
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68178481
103Prostate cancer_Homo sapiens_hsa052150.67468370
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67278963
105Pyruvate metabolism_Homo sapiens_hsa006200.64556658
106Sphingolipid metabolism_Homo sapiens_hsa006000.63683744
107TNF signaling pathway_Homo sapiens_hsa046680.62970700
108Purine metabolism_Homo sapiens_hsa002300.62722646
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62653848
110Hippo signaling pathway_Homo sapiens_hsa043900.62219482
111Galactose metabolism_Homo sapiens_hsa000520.61204143
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.61120519
113Spliceosome_Homo sapiens_hsa030400.60900587
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59986656
115Oocyte meiosis_Homo sapiens_hsa041140.59198360
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59151671
117Tyrosine metabolism_Homo sapiens_hsa003500.58991564
118Malaria_Homo sapiens_hsa051440.58989967
119mRNA surveillance pathway_Homo sapiens_hsa030150.58445522
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.58366808
121Melanoma_Homo sapiens_hsa052180.57653006
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56138661
123Epstein-Barr virus infection_Homo sapiens_hsa051690.54381667
124Nitrogen metabolism_Homo sapiens_hsa009100.54107265
125Tight junction_Homo sapiens_hsa045300.52003541
126Toxoplasmosis_Homo sapiens_hsa051450.51980004
127* Metabolic pathways_Homo sapiens_hsa011000.51101524
128Glioma_Homo sapiens_hsa052140.50362305
129Cyanoamino acid metabolism_Homo sapiens_hsa004600.48987854
130Amoebiasis_Homo sapiens_hsa051460.48970837
131Insulin signaling pathway_Homo sapiens_hsa049100.48854641
132Pathways in cancer_Homo sapiens_hsa052000.46896334
133Viral carcinogenesis_Homo sapiens_hsa052030.45717435
134ErbB signaling pathway_Homo sapiens_hsa040120.45206953
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.43539492
136Lysosome_Homo sapiens_hsa041420.42289117
137Renin-angiotensin system_Homo sapiens_hsa046140.41615443
138Mineral absorption_Homo sapiens_hsa049780.39861053
139Insulin resistance_Homo sapiens_hsa049310.37963852
140Bile secretion_Homo sapiens_hsa049760.31061097
141Protein export_Homo sapiens_hsa030600.31038041
142AMPK signaling pathway_Homo sapiens_hsa041520.30370169
143Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29475539
144Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29249284
145DNA replication_Homo sapiens_hsa030300.28972018
146Fatty acid elongation_Homo sapiens_hsa000620.28177918
147Hepatitis C_Homo sapiens_hsa051600.27736060
148One carbon pool by folate_Homo sapiens_hsa006700.25248103

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