UAP1L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.44865092
2positive regulation by organism of defense response of other organism involved in symbiotic interact4.44865092
3modulation by symbiont of host immune response (GO:0052553)4.44865092
4positive regulation by symbiont of host defense response (GO:0052509)4.44865092
5modulation by symbiont of host defense response (GO:0052031)4.44865092
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.44865092
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.43088571
8regulation of interferon-beta biosynthetic process (GO:0045357)4.32863832
9protein localization to endosome (GO:0036010)4.19041041
10neutrophil activation involved in immune response (GO:0002283)3.96908210
11negative regulation of erythrocyte differentiation (GO:0045647)3.94913389
12immunoglobulin mediated immune response (GO:0016064)3.79557251
13regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.62773896
14positive regulation of interferon-alpha production (GO:0032727)3.62484523
15COPI coating of Golgi vesicle (GO:0048205)3.59927949
16Golgi transport vesicle coating (GO:0048200)3.59927949
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.59164507
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.59164507
19Arp2/3 complex-mediated actin nucleation (GO:0034314)3.58501193
20pinocytosis (GO:0006907)3.45042478
21natural killer cell mediated cytotoxicity (GO:0042267)3.41613534
22natural killer cell mediated immunity (GO:0002228)3.41613534
23regulation of interferon-alpha production (GO:0032647)3.39753684
24oligosaccharide catabolic process (GO:0009313)3.39715756
25cellular response to thyroid hormone stimulus (GO:0097067)3.34660059
26macrophage activation involved in immune response (GO:0002281)3.33776446
27amino sugar catabolic process (GO:0046348)3.27245657
28response to peptidoglycan (GO:0032494)3.22628824
29antigen processing and presentation via MHC class Ib (GO:0002475)3.21252099
30regulation of leukocyte degranulation (GO:0043300)3.19618252
31positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.13353609
32regulation of mast cell degranulation (GO:0043304)3.12484063
33positive regulation of interferon-beta production (GO:0032728)3.08001974
34B cell mediated immunity (GO:0019724)3.05739229
35N-acetylneuraminate metabolic process (GO:0006054)3.04102979
36antigen processing and presentation of endogenous antigen (GO:0019883)3.03845719
37regulation of early endosome to late endosome transport (GO:2000641)3.03002808
38stress fiber assembly (GO:0043149)3.01839512
39negative regulation of interleukin-12 production (GO:0032695)2.99020427
40response to laminar fluid shear stress (GO:0034616)2.94639569
41lipopolysaccharide-mediated signaling pathway (GO:0031663)2.92941991
42positive regulation of receptor recycling (GO:0001921)2.92052280
43response to muramyl dipeptide (GO:0032495)2.91718248
44endosome to pigment granule transport (GO:0043485)2.91374127
45endosome to melanosome transport (GO:0035646)2.91374127
46positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.89805725
47regulation of B cell receptor signaling pathway (GO:0050855)2.83881666
48keratan sulfate catabolic process (GO:0042340)2.82954625
49respiratory burst (GO:0045730)2.82751911
50mannose metabolic process (GO:0006013)2.81153880
51regulation of mast cell activation involved in immune response (GO:0033006)2.80476043
52adhesion of symbiont to host (GO:0044406)2.79833935
53ceramide catabolic process (GO:0046514)2.79751527
54positive regulation of leukocyte degranulation (GO:0043302)2.79603945
55apoptotic cell clearance (GO:0043277)2.79421131
56positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.78600145
57actin nucleation (GO:0045010)2.77029638
58regulation of myeloid leukocyte mediated immunity (GO:0002886)2.76910840
59T cell apoptotic process (GO:0070231)2.76855984
60adhesion of symbiont to host cell (GO:0044650)2.76665451
61virion attachment to host cell (GO:0019062)2.76665451
62cellular response to arsenic-containing substance (GO:0071243)2.76503467
63negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.68672611
64response to interferon-alpha (GO:0035455)2.67573991
65response to host immune response (GO:0052572)2.67548777
66response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.67548777
67basement membrane organization (GO:0071711)2.64608948
68positive regulation of lymphocyte apoptotic process (GO:0070230)2.64241475
69formation of translation preinitiation complex (GO:0001731)2.63860107
70positive regulation of protein dephosphorylation (GO:0035307)2.62756732
71pentose-phosphate shunt (GO:0006098)2.62032156
72regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.59733638
73glycosphingolipid catabolic process (GO:0046479)2.59482181
74detection of molecule of bacterial origin (GO:0032490)2.56584951
75hyaluronan catabolic process (GO:0030214)2.56191692
76positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.56004477
77lysosome organization (GO:0007040)2.55674409
78lytic vacuole organization (GO:0080171)2.55674409
79positive regulation of antigen processing and presentation (GO:0002579)2.55156949
80positive regulation of Cdc42 GTPase activity (GO:0043089)2.54585665
81folic acid transport (GO:0015884)2.53869963
82regulation of integrin activation (GO:0033623)2.53487305
83glycolipid catabolic process (GO:0019377)2.52268639
84positive regulation of cellular amide metabolic process (GO:0034250)2.52177011
85maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.51702601
86L-alpha-amino acid transmembrane transport (GO:1902475)2.51463112
87membrane lipid catabolic process (GO:0046466)2.50377117
88myeloid cell homeostasis (GO:0002262)2.48844688
89antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.48043487
90regulation of interferon-beta production (GO:0032648)2.47858696
91regulation of regulated secretory pathway (GO:1903305)2.47582104
92regulation of extracellular matrix disassembly (GO:0010715)2.46980702
93semaphorin-plexin signaling pathway (GO:0071526)2.46918769
94modulation by symbiont of host cellular process (GO:0044068)2.46843707
95regulation of protein heterodimerization activity (GO:0043497)2.46647659
96sphingolipid catabolic process (GO:0030149)2.46588107
97positive regulation of T cell apoptotic process (GO:0070234)2.45884442
98regulation of superoxide anion generation (GO:0032928)2.45559465
99barbed-end actin filament capping (GO:0051016)2.43043241
100regulation of type I interferon-mediated signaling pathway (GO:0060338)2.41693541
101amyloid precursor protein catabolic process (GO:0042987)2.41367570
102lymphocyte apoptotic process (GO:0070227)2.40376637
103skin morphogenesis (GO:0043589)2.40183873
104glycoside metabolic process (GO:0016137)2.39570100
105germinal center formation (GO:0002467)2.39324450
106activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.38459937
107regulation of macrophage cytokine production (GO:0010935)2.37699542
108embryonic process involved in female pregnancy (GO:0060136)2.37270509
109peptide catabolic process (GO:0043171)2.36637433
110myeloid cell activation involved in immune response (GO:0002275)2.36144526
111regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.36092170
112response to host (GO:0075136)2.35548188
113response to host defenses (GO:0052200)2.35548188
114response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.35548188
115positive regulation of nuclease activity (GO:0032075)2.35163310
116chaperone mediated protein folding requiring cofactor (GO:0051085)2.34832006
117apoptotic process involved in morphogenesis (GO:0060561)2.34476783
118positive regulation of macrophage cytokine production (GO:0060907)2.34408314
119positive regulation of extracellular matrix organization (GO:1903055)2.34142664
120decidualization (GO:0046697)2.34099655
121protein retention in ER lumen (GO:0006621)2.33874006
122regulation of antigen processing and presentation (GO:0002577)2.33388424
123detection of other organism (GO:0098543)2.32644342
124response to interferon-beta (GO:0035456)2.32415038
125mature B cell differentiation involved in immune response (GO:0002313)2.31080113
126positive regulation of bone resorption (GO:0045780)2.30042280
127positive regulation of bone remodeling (GO:0046852)2.30042280
128epithelial cell differentiation involved in prostate gland development (GO:0060742)2.29835620
129cellular response to interferon-alpha (GO:0035457)2.29545581
130folic acid-containing compound biosynthetic process (GO:0009396)2.29534580
131retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.29261711
132regulation of T-helper 2 cell differentiation (GO:0045628)2.29118369
133production of molecular mediator involved in inflammatory response (GO:0002532)2.29075244
134antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.28738076
135response to thyroid hormone (GO:0097066)2.28623284
136detection of external biotic stimulus (GO:0098581)2.28572013
137cell adhesion mediated by integrin (GO:0033627)2.28466670
138positive regulation of chemokine biosynthetic process (GO:0045080)2.28226617
139regulation of integrin-mediated signaling pathway (GO:2001044)2.27820885
140NADPH regeneration (GO:0006740)2.26794185
141endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.26726852
142glucose catabolic process (GO:0006007)2.26672006
143neutrophil mediated immunity (GO:0002446)2.26239366
144response to magnesium ion (GO:0032026)2.26054247
145leukocyte mediated cytotoxicity (GO:0001909)2.26023287
146positive regulation of mast cell activation (GO:0033005)2.25891941
147negative regulation of protein localization to plasma membrane (GO:1903077)2.25710911
148positive regulation of mast cell activation involved in immune response (GO:0033008)2.25463932
149positive regulation of mast cell degranulation (GO:0043306)2.25463932
150NIK/NF-kappaB signaling (GO:0038061)2.25388736
151granulocyte activation (GO:0036230)2.25036989
152wound healing, spreading of epidermal cells (GO:0035313)2.24971301
153leukocyte apoptotic process (GO:0071887)2.24821081
154myeloid dendritic cell differentiation (GO:0043011)2.24447899
155low-density lipoprotein particle clearance (GO:0034383)2.24435496
156endothelial cell chemotaxis (GO:0035767)2.24033729
157positive regulation of SMAD protein import into nucleus (GO:0060391)2.23795056
158positive regulation of gamma-delta T cell activation (GO:0046645)2.23530033
159regulation of nuclease activity (GO:0032069)2.22772399
160folic acid metabolic process (GO:0046655)2.22170679
161endoplasmic reticulum unfolded protein response (GO:0030968)2.21973886
162negative regulation of cell size (GO:0045792)2.21160363
163negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.21093259
164negative regulation of cell killing (GO:0031342)2.21093259
165cortical actin cytoskeleton organization (GO:0030866)2.21069616

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse3.37212813
2E2F7_22180533_ChIP-Seq_HELA_Human3.31183259
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.23494697
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.71861467
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.65555015
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.42481700
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.42301416
8TFEB_21752829_ChIP-Seq_HELA_Human2.29588668
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.20063676
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.15852939
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13379388
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12224600
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.09766538
14* MYC_18555785_ChIP-Seq_MESCs_Mouse2.06384576
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.05607030
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.04852117
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.99914867
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96717598
19VDR_21846776_ChIP-Seq_THP-1_Human1.95241096
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.90111972
21KDM2B_26808549_Chip-Seq_DND41_Human1.86855534
22SPI1_23547873_ChIP-Seq_NB4_Human1.84909865
23FOXM1_23109430_ChIP-Seq_U2OS_Human1.83317433
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.81889726
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.80402783
26BRD4_27068464_Chip-Seq_AML-cells_Mouse1.79416322
27MYC_22102868_ChIP-Seq_BL_Human1.76615475
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.76224345
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72121219
30SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.63816856
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63587423
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.60830462
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60625275
34* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57681919
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.56486467
36* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55350337
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.54329136
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52730873
39KDM2B_26808549_Chip-Seq_K562_Human1.52380476
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52151639
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52133135
42* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.51357758
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.47346539
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46958284
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45274890
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.45214101
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.43633172
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42433810
49PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42405430
50* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40769964
51ZNF263_19887448_ChIP-Seq_K562_Human1.39747554
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39649953
53VDR_24763502_ChIP-Seq_THP-1_Human1.39485464
54CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38098766
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.37871676
56CLOCK_20551151_ChIP-Seq_293T_Human1.34662430
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33902427
58* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33345911
59* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32291542
60MAF_26560356_Chip-Seq_TH2_Human1.31631143
61MAF_26560356_Chip-Seq_TH1_Human1.31064374
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30176891
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29927829
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29671281
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26923411
66DCP1A_22483619_ChIP-Seq_HELA_Human1.26635469
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26612371
68UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26060534
69TP53_22127205_ChIP-Seq_IMR90_Human1.25983348
70VDR_23849224_ChIP-Seq_CD4+_Human1.25019255
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24879866
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24185076
73GATA1_19941827_ChIP-Seq_MEL_Mouse1.22029418
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21979183
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21835210
76STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21715639
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21544493
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21173129
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20981536
80BP1_19119308_ChIP-ChIP_Hs578T_Human1.20938660
81* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20632911
82P68_20966046_ChIP-Seq_HELA_Human1.19697839
83KDM2B_26808549_Chip-Seq_JURKAT_Human1.19495186
84XRN2_22483619_ChIP-Seq_HELA_Human1.19166608
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18789315
86SPI1_23127762_ChIP-Seq_K562_Human1.18455746
87* TET1_21451524_ChIP-Seq_MESCs_Mouse1.17991863
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17716355
89ATF3_27146783_Chip-Seq_COLON_Human1.17401752
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17130237
91SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16888139
92NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16718191
93ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16467395
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15978084
95UTX_26944678_Chip-Seq_JUKART_Human1.15939940
96GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15619028
97KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15434811
98SA1_27219007_Chip-Seq_ERYTHROID_Human1.15248482
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15174491
100NCOR1_26117541_ChIP-Seq_K562_Human1.14583783
101ESR1_21235772_ChIP-Seq_MCF-7_Human1.13707868
102ELF1_20517297_ChIP-Seq_JURKAT_Human1.13581646
103GABP_19822575_ChIP-Seq_HepG2_Human1.13424692
104MYB_26560356_Chip-Seq_TH2_Human1.13409283
105BCOR_27268052_Chip-Seq_Bcells_Human1.12402787
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12326044
107CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11973680
108EST1_17652178_ChIP-ChIP_JURKAT_Human1.11901120
109FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.11526242
110SMC4_20622854_ChIP-Seq_HELA_Human1.11296437
111CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10027883
112TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09828042
113MYB_26560356_Chip-Seq_TH1_Human1.08722496
114KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08335248
115* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07896719
116PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07417393
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06911533
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05802258
119ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05369790
120PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04788023
121ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04786124
122RACK7_27058665_Chip-Seq_MCF-7_Human1.04227851
123* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04051997
124TCF7_22412390_ChIP-Seq_EML_Mouse1.03516669
125SCL_19346495_ChIP-Seq_HPC-7_Human1.03323002
126UBF1/2_26484160_Chip-Seq_HMECs_Human1.02979244
127PU_27001747_Chip-Seq_BMDM_Mouse1.02221106
128ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02212690
129HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01436382
130RUNX1_27514584_Chip-Seq_MCF-7_Human1.01295861
131KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01263757
132GATA1_19941826_ChIP-Seq_K562_Human1.00650837
133GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99812581
134CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99489322
135WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98351332
136PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98285426
137* LXR_22292898_ChIP-Seq_THP-1_Human0.97674566
138HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97231517
139SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97013066
140CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96722298
141AR_21909140_ChIP-Seq_LNCAP_Human0.95985837
142SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94487402
143E2F4_17652178_ChIP-ChIP_JURKAT_Human0.93892656
144CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93781673
145TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92899792

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.74155490
2MP0003172_abnormal_lysosome_physiology3.28225595
3MP0008438_abnormal_cutaneous_collagen3.00379420
4MP0009840_abnormal_foam_cell2.93866836
5MP0005451_abnormal_body_composition2.61175955
6MP0003436_decreased_susceptibility_to2.41862761
7MP0005257_abnormal_intraocular_pressure2.41553434
8MP0001835_abnormal_antigen_presentation2.35239652
9MP0003705_abnormal_hypodermis_morpholog2.26755149
10MP0003303_peritoneal_inflammation2.24259295
11MP0010307_abnormal_tumor_latency2.23590680
12MP0006082_CNS_inflammation2.16132920
13MP0002877_abnormal_melanocyte_morpholog2.15536155
14MP0001958_emphysema2.01984360
15MP0002419_abnormal_innate_immunity1.93093868
16MP0003300_gastrointestinal_ulcer1.83137121
17MP0010352_gastrointestinal_tract_polyps1.80403239
18MP0003693_abnormal_embryo_hatching1.76764820
19MP0009278_abnormal_bone_marrow1.73271865
20MP0003566_abnormal_cell_adhesion1.73031142
21MP0003191_abnormal_cellular_cholesterol1.71938376
22MP0005000_abnormal_immune_tolerance1.71445476
23MP0009785_altered_susceptibility_to1.70078318
24MP0000858_altered_metastatic_potential1.64506839
25MP0002452_abnormal_antigen_presenting1.63969081
26MP0005025_abnormal_response_to1.58541741
27MP0009333_abnormal_splenocyte_physiolog1.57224461
28MP0005464_abnormal_platelet_physiology1.55875729
29MP0001533_abnormal_skeleton_physiology1.52972933
30MP0003448_altered_tumor_morphology1.51611573
31MP0000371_diluted_coat_color1.51244274
32MP0005023_abnormal_wound_healing1.49604396
33MP0000490_abnormal_crypts_of1.48910484
34MP0004947_skin_inflammation1.48519574
35MP0003453_abnormal_keratinocyte_physiol1.46714660
36MP0000685_abnormal_immune_system1.45810490
37MP0002148_abnormal_hypersensitivity_rea1.45700864
38MP0005397_hematopoietic_system_phenotyp1.45301069
39MP0001545_abnormal_hematopoietic_system1.45301069
40MP0000569_abnormal_digit_pigmentation1.43413598
41MP0002254_reproductive_system_inflammat1.42472312
42MP0005171_absent_coat_pigmentation1.41807905
43MP0002723_abnormal_immune_serum1.39668850
44MP0003075_altered_response_to1.36229214
45MP0001819_abnormal_immune_cell1.35569730
46MP0002420_abnormal_adaptive_immunity1.34597250
47MP0005387_immune_system_phenotype1.33060877
48MP0001790_abnormal_immune_system1.33060877
49MP0001800_abnormal_humoral_immune1.30612060
50MP0002405_respiratory_system_inflammati1.30542665
51MP0005076_abnormal_cell_differentiation1.29677944
52MP0003183_abnormal_peptide_metabolism1.28959675
53MP0005174_abnormal_tail_pigmentation1.24626546
54MP0001348_abnormal_lacrimal_gland1.24246968
55MP0003329_amyloid_beta_deposits1.22235628
56MP0002998_abnormal_bone_remodeling1.20446755
57MP0006054_spinal_hemorrhage1.20294538
58MP0001845_abnormal_inflammatory_respons1.20138826
59MP0004808_abnormal_hematopoietic_stem1.19661067
60MP0004858_abnormal_nervous_system1.19375342
61MP0005310_abnormal_salivary_gland1.18534041
62MP0000689_abnormal_spleen_morphology1.17887832
63MP0002396_abnormal_hematopoietic_system1.17325227
64MP0004233_abnormal_muscle_weight1.15373582
65MP0004381_abnormal_hair_follicle1.14568661
66MP0003279_aneurysm1.14200777
67MP0010234_abnormal_vibrissa_follicle1.14119137
68MP0000767_abnormal_smooth_muscle1.14050484
69MP0005671_abnormal_response_to1.13598687
70MP0001853_heart_inflammation1.12291297
71MP0000343_altered_response_to1.10829487
72MP0004957_abnormal_blastocyst_morpholog1.09614786
73MP0003111_abnormal_nucleus_morphology1.08863886
74MP0002166_altered_tumor_susceptibility1.07251856
75MP0005275_abnormal_skin_tensile1.07204544
76MP0002722_abnormal_immune_system1.06708109
77MP0000015_abnormal_ear_pigmentation1.06472027
78MP0000716_abnormal_immune_system1.06107655
79MP0003828_pulmonary_edema1.05228277
80MP0002398_abnormal_bone_marrow1.04605246
81MP0004510_myositis1.04223634
82MP0008469_abnormal_protein_level1.03791474
83MP0003091_abnormal_cell_migration1.01929745
84MP0010155_abnormal_intestine_physiology1.01879700
85MP0002933_joint_inflammation1.01861001
86MP0000465_gastrointestinal_hemorrhage1.01388413
87MP0005390_skeleton_phenotype1.00324053
88MP0003795_abnormal_bone_structure0.99365896
89MP0000372_irregular_coat_pigmentation0.99342361
90MP0002429_abnormal_blood_cell0.99158758
91MP0009384_cardiac_valve_regurgitation0.98114302
92MP0000920_abnormal_myelination0.91720182
93MP0000358_abnormal_cell_content/0.91135525
94MP0002896_abnormal_bone_mineralization0.90568165
95MP0008260_abnormal_autophagy0.90552875
96MP0000604_amyloidosis0.90259563
97MP0005503_abnormal_tendon_morphology0.89269496
98MP0002075_abnormal_coat/hair_pigmentati0.89137119
99MP0005409_darkened_coat_color0.88291990
100MP0003186_abnormal_redox_activity0.88058887
101MP0004185_abnormal_adipocyte_glucose0.87927917
102MP0003724_increased_susceptibility_to0.87744443
103MP0003690_abnormal_glial_cell0.87439770
104MP0008007_abnormal_cellular_replicative0.86933825
105MP0003634_abnormal_glial_cell0.84837110
106MP0009643_abnormal_urine_homeostasis0.84200011
107MP0003077_abnormal_cell_cycle0.84195933
108MP0000747_muscle_weakness0.81875132
109MP0001873_stomach_inflammation0.81626800
110MP0002019_abnormal_tumor_incidence0.80042297
111MP0002006_tumorigenesis0.79840929
112MP0005621_abnormal_cell_physiology0.79724161
113MP0004272_abnormal_basement_membrane0.79716952
114MP0002136_abnormal_kidney_physiology0.79466607
115MP0000733_abnormal_muscle_development0.78793602
116MP0001849_ear_inflammation0.78011094
117MP0001542_abnormal_bone_strength0.77987359
118MP0002060_abnormal_skin_morphology0.77180308
119MP0001243_abnormal_dermal_layer0.75709020
120MP0001756_abnormal_urination0.75163269
121MP0005083_abnormal_biliary_tract0.74722156
122MP0001186_pigmentation_phenotype0.74009008
123MP0002089_abnormal_postnatal_growth/wei0.73114906
124MP0005075_abnormal_melanosome_morpholog0.72942100
125MP0005595_abnormal_vascular_smooth0.72777425
126MP0000313_abnormal_cell_death0.70955913
127MP0000598_abnormal_liver_morphology0.70380203
128MP0002135_abnormal_kidney_morphology0.70324933
129MP0000750_abnormal_muscle_regeneration0.67275286
130MP0005384_cellular_phenotype0.65950866

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)5.56537089
2Increased cerebral lipofuscin (HP:0011813)5.55489339
3Dysostosis multiplex (HP:0000943)5.15835941
4Increased neuronal autofluorescent lipopigment (HP:0002074)4.82712684
5Abnormality of glycolipid metabolism (HP:0010969)4.61302557
6Abnormality of liposaccharide metabolism (HP:0010968)4.61302557
7Abnormality of glycosphingolipid metabolism (HP:0004343)4.61302557
8Mucopolysacchariduria (HP:0008155)4.43592897
9Urinary glycosaminoglycan excretion (HP:0003541)4.43592897
10Recurrent abscess formation (HP:0002722)4.30380613
11Abnormality of mucopolysaccharide metabolism (HP:0011020)4.21744618
12Abnormality of polysaccharide metabolism (HP:0011012)4.21744618
13Abnormality of glycosaminoglycan metabolism (HP:0004371)4.21744618
14Abnormality of macrophages (HP:0004311)3.90558832
15Premature rupture of membranes (HP:0001788)3.79546207
16Cervical subluxation (HP:0003308)3.67752283
17Vertebral compression fractures (HP:0002953)3.64551521
18Eczematoid dermatitis (HP:0000976)3.53584859
19Recurrent bacterial skin infections (HP:0005406)3.51418715
20Protrusio acetabuli (HP:0003179)3.20143102
21Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.14362129
22Axonal loss (HP:0003447)3.02707584
23Cerebral aneurysm (HP:0004944)2.70742218
24Disinhibition (HP:0000734)2.68766325
25Pustule (HP:0200039)2.68535940
26Elevated erythrocyte sedimentation rate (HP:0003565)2.66645473
27Hyperacusis (HP:0010780)2.66443315
28Ankle contracture (HP:0006466)2.64891169
29Loss of speech (HP:0002371)2.61884872
30Agnosia (HP:0010524)2.60270142
31Interstitial pulmonary disease (HP:0006530)2.58886829
32Osteolytic defects of the phalanges of the hand (HP:0009771)2.58286653
33Osteolytic defects of the hand bones (HP:0009699)2.58286653
34Nuclear cataract (HP:0100018)2.54587115
35Neurofibrillary tangles (HP:0002185)2.52642981
36Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.46189979
37Abnormality of the vasculature of the conjunctiva (HP:0008054)2.45421488
38Personality changes (HP:0000751)2.44749718
39Petechiae (HP:0000967)2.41942920
40Gingivitis (HP:0000230)2.40902937
41Recurrent gram-negative bacterial infections (HP:0005420)2.35885669
42Joint stiffness (HP:0001387)2.34572551
43Autoimmune thrombocytopenia (HP:0001973)2.33886192
44Achilles tendon contracture (HP:0001771)2.31126138
45Pathologic fracture (HP:0002756)2.29979011
46Abnormality of the distal phalanges of the toes (HP:0010182)2.27969456
47Beaking of vertebral bodies (HP:0004568)2.27080363
48Cerebral inclusion bodies (HP:0100314)2.24206484
49Myositis (HP:0100614)2.21709952
50Poor head control (HP:0002421)2.21029240
51Global brain atrophy (HP:0002283)2.20926910
52Hand muscle atrophy (HP:0009130)2.20722897
53Asymmetric septal hypertrophy (HP:0001670)2.17770519
54Basal ganglia calcification (HP:0002135)2.17374290
55Progressive neurologic deterioration (HP:0002344)2.17001779
56Obstructive lung disease (HP:0006536)2.13949512
57Chronic obstructive pulmonary disease (HP:0006510)2.13949512
58Deformed sella turcica (HP:0002681)2.11814793
59Systemic lupus erythematosus (HP:0002725)2.10318858
60Prolonged neonatal jaundice (HP:0006579)2.09414983
61Spontaneous hematomas (HP:0007420)2.09285419
62Tetraparesis (HP:0002273)2.06954032
63Gastrointestinal stroma tumor (HP:0100723)2.06249348
64Increased connective tissue (HP:0009025)2.05342324
65Thrombocytosis (HP:0001894)2.03677557
66Neuronal loss in central nervous system (HP:0002529)2.03475148
67Abnormality of the Achilles tendon (HP:0005109)2.02954248
68Spinal muscular atrophy (HP:0007269)2.01826408
69Purpura (HP:0000979)2.01635730
70Diminished motivation (HP:0000745)2.00466400
71Distal lower limb muscle weakness (HP:0009053)2.00256268
72Conjunctival telangiectasia (HP:0000524)2.00172672
73Recurrent skin infections (HP:0001581)1.98148535
74Cardiomegaly (HP:0001640)1.97587575
75Ocular albinism (HP:0001107)1.97542412
76Broad face (HP:0000283)1.97195412
77Hepatosplenomegaly (HP:0001433)1.95525486
78Myocardial infarction (HP:0001658)1.95093031
79Distal upper limb amyotrophy (HP:0007149)1.93383784
80Upper limb amyotrophy (HP:0009129)1.93383784
81Recurrent fungal infections (HP:0002841)1.92523267
82Soft skin (HP:0000977)1.92338071
83Albinism (HP:0001022)1.92015180
84Spinal rigidity (HP:0003306)1.91691793
85Thoracic kyphosis (HP:0002942)1.90695548
86Cellulitis (HP:0100658)1.89510792
87Bone pain (HP:0002653)1.88223679
88Distal lower limb amyotrophy (HP:0008944)1.86681798
89Ovoid vertebral bodies (HP:0003300)1.86577987
90Severe short stature (HP:0003510)1.85985149
91Entropion (HP:0000621)1.85632316
92Peritonitis (HP:0002586)1.85124181
93Amyloidosis (HP:0011034)1.83874939
94Aneurysm (HP:0002617)1.83865454
95Dilatation of the ascending aorta (HP:0005111)1.83608138
96Emphysema (HP:0002097)1.82156958
97Supranuclear gaze palsy (HP:0000605)1.80776718
98Abnormality of the acetabulum (HP:0003170)1.80659234
99Colitis (HP:0002583)1.80519828
100Restrictive lung disease (HP:0002091)1.80478460
101Genu recurvatum (HP:0002816)1.80227351
102Mediastinal lymphadenopathy (HP:0100721)1.79937036
103Nonimmune hydrops fetalis (HP:0001790)1.76604452
104J-shaped sella turcica (HP:0002680)1.75263570
105Thin bony cortex (HP:0002753)1.74830687
106Abnormal platelet function (HP:0011869)1.74479400
107Impaired platelet aggregation (HP:0003540)1.74479400
108Bladder diverticulum (HP:0000015)1.74201293
109Abnormality of the umbilical cord (HP:0010881)1.73870852
110Long toe (HP:0010511)1.72901044
111Hematochezia (HP:0002573)1.72817373
112Wormian bones (HP:0002645)1.71396154
113Abnormality of the odontoid process (HP:0003310)1.71382992
114Premature loss of primary teeth (HP:0006323)1.71030410
115Periodontitis (HP:0000704)1.69784996
116Segmental peripheral demyelination/remyelination (HP:0003481)1.69039088
117Osteomyelitis (HP:0002754)1.68771350
118Apathy (HP:0000741)1.68460885
119Abnormality of the thoracic spine (HP:0100711)1.68025709
120Natal tooth (HP:0000695)1.67640312
121Biconcave vertebral bodies (HP:0004586)1.66988770
122Flat acetabular roof (HP:0003180)1.66970413
123Hypoplasia of the odontoid process (HP:0003311)1.66351201
124Spondylolisthesis (HP:0003302)1.66187823
125Orchitis (HP:0100796)1.65538622
126Upper motor neuron abnormality (HP:0002127)1.64078316
127Ulnar bowing (HP:0003031)1.62774824
128Blue sclerae (HP:0000592)1.62725269
129Increased serum ferritin (HP:0003281)1.61340291
130Abnormality of skull ossification (HP:0002703)1.61278286
131Short nail (HP:0001799)1.61150774
132Mitral regurgitation (HP:0001653)1.61019156
133Generalized amyotrophy (HP:0003700)1.59634239
134Sparse lateral eyebrow (HP:0005338)1.58996241
135Elbow flexion contracture (HP:0002987)1.58254723
136Persistence of primary teeth (HP:0006335)1.57118790
137Increased variability in muscle fiber diameter (HP:0003557)1.56850772
138Stridor (HP:0010307)1.56823477
139Fragile skin (HP:0001030)1.56326899

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.61496710
2ERN13.36669648
3PRPF4B2.99680361
4TRIB32.81845872
5SCYL22.76217020
6SIK12.48520715
7BLK2.45109306
8PIM22.38398118
9KIT2.34175261
10TBK12.30264756
11PKN22.11154614
12SMG12.10573861
13MAP3K132.08226370
14IRAK32.03183914
15ICK2.00997434
16PAK41.84275045
17BUB11.84192057
18EPHA21.81794548
19TYK21.80831709
20RPS6KA41.70742772
21MAP4K11.67688730
22LRRK21.67215718
23PRKD21.62490749
24TESK21.62361047
25WEE11.60162213
26TGFBR21.58841854
27MAP2K31.57448578
28TTN1.55070714
29ZAP701.49672722
30CDC42BPA1.47237640
31DDR21.46546715
32NEK21.45365940
33MAP3K31.43435575
34EEF2K1.41843132
35CAMKK21.34749724
36FGFR41.34334655
37IKBKB1.28013834
38FLT31.27653662
39IRAK41.26837116
40STK101.23704242
41KDR1.23176456
42NEK91.21909230
43TESK11.20241755
44CSF1R1.17906297
45JAK31.14503843
46MAP3K111.13743832
47MAP3K81.11380098
48PTK61.10029739
49PDPK11.07818547
50MAP3K101.05005657
51BMX1.03054650
52PIM11.01904208
53TAOK11.01897658
54TNK21.00116259
55TLK10.99664325
56RIPK40.99437668
57TAOK30.99425491
58IKBKE0.98489108
59MAP3K10.96107559
60CAMK1D0.95903639
61MOS0.91106047
62PASK0.90324309
63PDGFRA0.90207015
64MARK20.88501028
65HCK0.87645260
66EIF2AK30.87586144
67PRKD30.87529750
68RPS6KA20.86658397
69SIK30.86598971
70SIK20.85455890
71MST1R0.85245156
72KSR20.85065447
73ABL20.84709479
74BTK0.83423568
75MAPK110.82808674
76MATK0.82324722
77BRSK20.81741086
78CSK0.81593490
79ARAF0.80888489
80MAP2K20.80669029
81MAP3K60.79373670
82PAK20.76688873
83CDK120.75506591
84JAK10.75382871
85TAOK20.75321434
86FGR0.75301259
87LYN0.71046738
88PTK20.70310430
89RIPK10.70160145
90ACVR1B0.68429985
91IRAK20.67441595
92EPHB10.66835905
93MAP3K140.66829835
94EIF2AK10.66243701
95PDK10.64456945
96PAK10.64186699
97RPS6KC10.64123013
98RPS6KL10.64123013
99SYK0.63064729
100CDK70.62021705
101DYRK1B0.60724394
102PRKG20.60285899
103CHUK0.59875471
104MARK30.59822047
105CDK60.59757883
106LCK0.59612533
107MAPK70.59520827
108LMTK20.58839979
109DAPK30.58313602
110RPS6KB20.57085630
111MAPK120.56394664
112TEC0.55521768
113FES0.55071762
114MAPKAPK30.54975836
115PDGFRB0.54844650
116TRPM70.54479700
117HIPK20.54179620
118STK380.53848439
119MAP2K60.51742118
120AURKB0.51583320
121LATS20.51491754
122STK40.49787147
123MTOR0.49108660
124BCKDK0.48496644
125NEK10.47934587
126GRK60.47262833
127PLK10.46689109
128RPS6KA60.46169474
129MAP3K70.46088878
130ALK0.44907660
131CDK40.44513100
132JAK20.44263268
133RET0.43997209
134LIMK10.43660232
135STK30.42843870
136ABL10.42745182
137TYRO30.42657488
138DYRK30.42623931
139MET0.41960397
140PRKD10.40449123
141CAMKK10.38561178

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysosome_Homo sapiens_hsa041423.72193923
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.67275920
3Other glycan degradation_Homo sapiens_hsa005113.48788412
4* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.14128332
5Leishmaniasis_Homo sapiens_hsa051402.00155491
6Antigen processing and presentation_Homo sapiens_hsa046121.89568933
7Proteasome_Homo sapiens_hsa030501.64297943
8Phagosome_Homo sapiens_hsa041451.63511197
9Legionellosis_Homo sapiens_hsa051341.61881215
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.60257888
11Tuberculosis_Homo sapiens_hsa051521.58742203
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.56519025
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.55773635
14Osteoclast differentiation_Homo sapiens_hsa043801.53058417
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.51685558
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49777219
17DNA replication_Homo sapiens_hsa030301.49750647
18Apoptosis_Homo sapiens_hsa042101.49564394
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44874091
20Shigellosis_Homo sapiens_hsa051311.40299985
21Galactose metabolism_Homo sapiens_hsa000521.40023532
22p53 signaling pathway_Homo sapiens_hsa041151.38631468
23Folate biosynthesis_Homo sapiens_hsa007901.37707405
24Malaria_Homo sapiens_hsa051441.36450071
25Renin-angiotensin system_Homo sapiens_hsa046141.35948844
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.35886877
27Caffeine metabolism_Homo sapiens_hsa002321.28801002
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.27946625
29VEGF signaling pathway_Homo sapiens_hsa043701.27525851
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.24743224
31Allograft rejection_Homo sapiens_hsa053301.20563828
32Measles_Homo sapiens_hsa051621.19336415
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.19157595
34Rheumatoid arthritis_Homo sapiens_hsa053231.17946897
35Pertussis_Homo sapiens_hsa051331.17266724
36Ribosome_Homo sapiens_hsa030101.17012811
37Base excision repair_Homo sapiens_hsa034101.13247737
38B cell receptor signaling pathway_Homo sapiens_hsa046621.12002557
39Pentose phosphate pathway_Homo sapiens_hsa000301.11029164
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10126363
41Non-small cell lung cancer_Homo sapiens_hsa052231.09792027
42Sphingolipid metabolism_Homo sapiens_hsa006001.07941800
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06895394
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06535937
45Notch signaling pathway_Homo sapiens_hsa043301.06245794
46Sulfur relay system_Homo sapiens_hsa041221.01538612
47Chronic myeloid leukemia_Homo sapiens_hsa052201.00265667
48Bladder cancer_Homo sapiens_hsa052191.00128174
49Staphylococcus aureus infection_Homo sapiens_hsa051500.99880423
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99792100
51Mismatch repair_Homo sapiens_hsa034300.99726602
52Viral carcinogenesis_Homo sapiens_hsa052030.99353492
53Prion diseases_Homo sapiens_hsa050200.98435176
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97966867
55Renal cell carcinoma_Homo sapiens_hsa052110.96547391
56Fructose and mannose metabolism_Homo sapiens_hsa000510.96283415
57Influenza A_Homo sapiens_hsa051640.95796828
58Viral myocarditis_Homo sapiens_hsa054160.95585165
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.95267175
60Graft-versus-host disease_Homo sapiens_hsa053320.94336780
61Autoimmune thyroid disease_Homo sapiens_hsa053200.94224334
62Salmonella infection_Homo sapiens_hsa051320.93589005
63One carbon pool by folate_Homo sapiens_hsa006700.93546242
64Asthma_Homo sapiens_hsa053100.93299681
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.93131124
66Toxoplasmosis_Homo sapiens_hsa051450.92676476
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.90096750
68Hepatitis B_Homo sapiens_hsa051610.89322775
69Herpes simplex infection_Homo sapiens_hsa051680.88460845
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.87440406
71GnRH signaling pathway_Homo sapiens_hsa049120.86928849
72N-Glycan biosynthesis_Homo sapiens_hsa005100.83332526
73Vibrio cholerae infection_Homo sapiens_hsa051100.82477557
74Epstein-Barr virus infection_Homo sapiens_hsa051690.82157185
75Collecting duct acid secretion_Homo sapiens_hsa049660.81866146
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81194874
77TNF signaling pathway_Homo sapiens_hsa046680.80412953
78Prolactin signaling pathway_Homo sapiens_hsa049170.79720314
79Endometrial cancer_Homo sapiens_hsa052130.79538342
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75266856
81Nucleotide excision repair_Homo sapiens_hsa034200.75080458
82Small cell lung cancer_Homo sapiens_hsa052220.74896739
83Chemokine signaling pathway_Homo sapiens_hsa040620.74322502
84RNA transport_Homo sapiens_hsa030130.73210037
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72897588
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72336590
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.70964184
88T cell receptor signaling pathway_Homo sapiens_hsa046600.69795726
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69689561
90Cell cycle_Homo sapiens_hsa041100.69574751
91Hematopoietic cell lineage_Homo sapiens_hsa046400.69400610
92Pyrimidine metabolism_Homo sapiens_hsa002400.69079065
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68820445
94Estrogen signaling pathway_Homo sapiens_hsa049150.68241053
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67842011
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67675756
97Insulin resistance_Homo sapiens_hsa049310.67276821
98Acute myeloid leukemia_Homo sapiens_hsa052210.67257718
99Type I diabetes mellitus_Homo sapiens_hsa049400.67243404
100RNA polymerase_Homo sapiens_hsa030200.67202183
101Proteoglycans in cancer_Homo sapiens_hsa052050.66406991
102Glioma_Homo sapiens_hsa052140.64868209
103Pancreatic cancer_Homo sapiens_hsa052120.64404200
104Amoebiasis_Homo sapiens_hsa051460.63985190
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.62711441
106Prostate cancer_Homo sapiens_hsa052150.62686492
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62109839
108Vitamin B6 metabolism_Homo sapiens_hsa007500.62073946
109Endocytosis_Homo sapiens_hsa041440.61715396
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61353690
111Insulin signaling pathway_Homo sapiens_hsa049100.61268466
112Regulation of autophagy_Homo sapiens_hsa041400.60786558
113Inositol phosphate metabolism_Homo sapiens_hsa005620.60156918
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60065318
115HIF-1 signaling pathway_Homo sapiens_hsa040660.58664098
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.58308901
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58078202
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57636798
119Hepatitis C_Homo sapiens_hsa051600.55637939
120ErbB signaling pathway_Homo sapiens_hsa040120.55564481
121Mineral absorption_Homo sapiens_hsa049780.55309592
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55138039
123Homologous recombination_Homo sapiens_hsa034400.52828121
124mTOR signaling pathway_Homo sapiens_hsa041500.52794808
125Vitamin digestion and absorption_Homo sapiens_hsa049770.52611930
126Protein export_Homo sapiens_hsa030600.51985209
127HTLV-I infection_Homo sapiens_hsa051660.50688047
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.47831716
129Focal adhesion_Homo sapiens_hsa045100.47706044
130Systemic lupus erythematosus_Homo sapiens_hsa053220.45724239
131MicroRNAs in cancer_Homo sapiens_hsa052060.44757215
132Platelet activation_Homo sapiens_hsa046110.42886322
133Selenocompound metabolism_Homo sapiens_hsa004500.42587342
134Drug metabolism - other enzymes_Homo sapiens_hsa009830.41923537
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.41677585

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