UBA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-arginine omega-N-methylation (GO:0035247)4.50491240
2pre-miRNA processing (GO:0031054)4.43536116
3retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.36821218
4regulation of translational fidelity (GO:0006450)4.33194280
5protein retention in ER lumen (GO:0006621)4.27776440
6regulation of translational termination (GO:0006449)4.26648559
7peptidyl-arginine N-methylation (GO:0035246)4.22990499
8peptidyl-arginine methylation (GO:0018216)4.22990499
9DNA unwinding involved in DNA replication (GO:0006268)4.14010086
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.11214586
11spliceosomal tri-snRNP complex assembly (GO:0000244)3.86031280
12nuclear pore complex assembly (GO:0051292)3.85769488
13layer formation in cerebral cortex (GO:0021819)3.81389408
14regulation of mammary gland epithelial cell proliferation (GO:0033599)3.79471430
15nuclear pore organization (GO:0006999)3.76725817
16negative regulation of cell size (GO:0045792)3.68922997
17dosage compensation (GO:0007549)3.67490752
18peptidyl-lysine dimethylation (GO:0018027)3.62146439
19histone arginine methylation (GO:0034969)3.58486034
20proline biosynthetic process (GO:0006561)3.55091072
21glucocorticoid receptor signaling pathway (GO:0042921)3.53051348
22negative regulation of microtubule polymerization (GO:0031115)3.52572940
23regulation of NFAT protein import into nucleus (GO:0051532)3.51112768
24cell-substrate adherens junction assembly (GO:0007045)3.50748221
25focal adhesion assembly (GO:0048041)3.50748221
26heterochromatin organization (GO:0070828)3.50171442
27semaphorin-plexin signaling pathway (GO:0071526)3.43052455
28NLS-bearing protein import into nucleus (GO:0006607)3.38323095
29nuclear envelope disassembly (GO:0051081)3.33293744
30membrane disassembly (GO:0030397)3.33293744
31mitotic nuclear envelope disassembly (GO:0007077)3.31296697
32activation of Rac GTPase activity (GO:0032863)3.29929650
33negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.28535676
34negative regulation of histone methylation (GO:0031061)3.24829454
35folic acid-containing compound biosynthetic process (GO:0009396)3.23831117
36COPI coating of Golgi vesicle (GO:0048205)3.22559905
37Golgi transport vesicle coating (GO:0048200)3.22559905
38convergent extension (GO:0060026)3.14644904
39cell-substrate junction assembly (GO:0007044)3.11812533
40apoptotic process involved in morphogenesis (GO:0060561)3.11294724
41protein localization to endosome (GO:0036010)3.06494340
42establishment of nucleus localization (GO:0040023)3.05213045
43pentose-phosphate shunt (GO:0006098)3.04315060
44Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.04184184
45regulation of RNA export from nucleus (GO:0046831)3.02883278
46protein-DNA complex disassembly (GO:0032986)3.02251646
47nucleosome disassembly (GO:0006337)3.02251646
48pyrimidine nucleobase catabolic process (GO:0006208)3.00337563
49protein localization to kinetochore (GO:0034501)3.00332771
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.00070513
51regulation of glucose import in response to insulin stimulus (GO:2001273)2.99545981
52epithelial cell-cell adhesion (GO:0090136)2.99123395
53positive regulation of RNA splicing (GO:0033120)2.97821191
54cytoskeletal anchoring at plasma membrane (GO:0007016)2.97184518
55regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.97182818
56histone H2A monoubiquitination (GO:0035518)2.96716594
57ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.95761165
58cerebellar Purkinje cell layer development (GO:0021680)2.93699084
59cell migration in hindbrain (GO:0021535)2.92758540
60positive regulation of synapse maturation (GO:0090129)2.92293860
61basement membrane organization (GO:0071711)2.92001131
62regulation of establishment of planar polarity (GO:0090175)2.89747668
63cell-cell junction maintenance (GO:0045217)2.89624365
64hippo signaling (GO:0035329)2.89465445
65glucose 6-phosphate metabolic process (GO:0051156)2.87672921
66nuclear envelope organization (GO:0006998)2.87471295
67dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.86997976
68intracellular estrogen receptor signaling pathway (GO:0030520)2.86765862
69corticosteroid receptor signaling pathway (GO:0031958)2.85994841
70mitotic nuclear envelope reassembly (GO:0007084)2.84395753
71nuclear envelope reassembly (GO:0031468)2.84395753
72alternative mRNA splicing, via spliceosome (GO:0000380)2.82630249
73polarized epithelial cell differentiation (GO:0030859)2.82597058
74negative regulation of RNA splicing (GO:0033119)2.80198958
75positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.79530688
76vesicle coating (GO:0006901)2.77800387
77hemidesmosome assembly (GO:0031581)2.76883082
78positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.76711614
79embryonic foregut morphogenesis (GO:0048617)2.76444378
80mRNA stabilization (GO:0048255)2.75074765
81RNA stabilization (GO:0043489)2.75074765
82DNA duplex unwinding (GO:0032508)2.71087814
833-UTR-mediated mRNA stabilization (GO:0070935)2.70619670
84barbed-end actin filament capping (GO:0051016)2.68946166
85protein localization to microtubule (GO:0035372)2.68747234
86DNA geometric change (GO:0032392)2.67577138
87negative regulation of mRNA metabolic process (GO:1903312)2.66835228
88cellular response to epidermal growth factor stimulus (GO:0071364)2.65974195
89epithelial cell differentiation involved in prostate gland development (GO:0060742)2.65363740
90adherens junction assembly (GO:0034333)2.63877055
91glucose catabolic process (GO:0006007)2.63297073
92protein maturation by protein folding (GO:0022417)2.62674723
93protein complex localization (GO:0031503)2.62610456
94NADPH regeneration (GO:0006740)2.62497231
95paraxial mesoderm development (GO:0048339)2.62292816
96regulation of early endosome to late endosome transport (GO:2000641)2.62091880
97sister chromatid segregation (GO:0000819)2.61470813
98cochlea morphogenesis (GO:0090103)2.60665741
99glial cell proliferation (GO:0014009)2.59991569
100planar cell polarity pathway involved in neural tube closure (GO:0090179)2.59110726
101regulation of translational elongation (GO:0006448)2.58349021
102establishment of apical/basal cell polarity (GO:0035089)2.58075670
103regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.57774745
104mitotic sister chromatid cohesion (GO:0007064)2.57652049
105regulation of chromatin binding (GO:0035561)2.57103602
106negative regulation of mRNA processing (GO:0050686)2.56810521
107IMP biosynthetic process (GO:0006188)2.56479713
108gene silencing by RNA (GO:0031047)2.55841274
109regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.55624618
110pore complex assembly (GO:0046931)2.55346653
111response to epidermal growth factor (GO:0070849)2.55058915
112amyloid precursor protein catabolic process (GO:0042987)2.54393128
113negative regulation of catenin import into nucleus (GO:0035414)2.53875163
114positive regulation of SMAD protein import into nucleus (GO:0060391)2.52730661
115stress fiber assembly (GO:0043149)2.52418789
116mitotic chromosome condensation (GO:0007076)2.52417929
117glycolytic process (GO:0006096)2.51842297
118protein export from nucleus (GO:0006611)2.51168339
119gene silencing (GO:0016458)2.49874541
120desmosome organization (GO:0002934)2.49302732
121sodium ion export (GO:0071436)2.48707908
122regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.48437380
123stress granule assembly (GO:0034063)2.47181914
124regulation of sister chromatid cohesion (GO:0007063)2.47125382
125peptidyl-arginine modification (GO:0018195)2.46559442
126ectodermal placode formation (GO:0060788)2.45885619
127regulation of nucleobase-containing compound transport (GO:0032239)2.43906848
128adherens junction organization (GO:0034332)2.43509204
129cellular protein complex localization (GO:0034629)2.43242763
130regulation of hippo signaling (GO:0035330)2.43081325
131regulation of SMAD protein import into nucleus (GO:0060390)2.42963127
132branching involved in mammary gland duct morphogenesis (GO:0060444)2.42522188
133regulation of mitotic spindle organization (GO:0060236)2.41274669
134cytoplasmic mRNA processing body assembly (GO:0033962)2.40111121
135mitotic spindle organization (GO:0007052)2.40003660
136chromatin assembly (GO:0031497)2.39855723
137modulation by virus of host morphology or physiology (GO:0019048)2.39475089
138positive regulation of receptor biosynthetic process (GO:0010870)2.38885468
139regulation of spindle organization (GO:0090224)2.38206444
140positive regulation of blood vessel endothelial cell migration (GO:0043536)2.37864746
141eye morphogenesis (GO:0048592)2.36546242
142regulation of DNA damage checkpoint (GO:2000001)2.36531605
143activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.35886748
144camera-type eye morphogenesis (GO:0048593)2.35665004
145protein targeting to plasma membrane (GO:0072661)2.35302344
146positive regulation of nuclease activity (GO:0032075)2.34622189
147maternal placenta development (GO:0001893)2.34587900
148snRNA metabolic process (GO:0016073)2.34401024
149mitochondrion transport along microtubule (GO:0047497)2.33877619
150establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.33877619
151positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.32532884
152regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.32532884
153endoplasmic reticulum unfolded protein response (GO:0030968)2.32404977
154DNA replication-dependent nucleosome organization (GO:0034723)2.31706565
155DNA replication-dependent nucleosome assembly (GO:0006335)2.31706565
156regulation of protein heterodimerization activity (GO:0043497)2.31022537
157gastrulation with mouth forming second (GO:0001702)2.30812383
158negative regulation of organelle assembly (GO:1902116)2.29837089

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.94063591
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.09760844
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.90631073
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.46277258
5MYC_22102868_ChIP-Seq_BL_Human3.44073340
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.74979722
7ZFP281_18757296_ChIP-ChIP_E14_Mouse2.62109665
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.55646047
9ZNF263_19887448_ChIP-Seq_K562_Human2.34664980
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.33312385
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.25128126
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.24822325
13KDM2B_26808549_Chip-Seq_DND41_Human2.18715733
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.12203840
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.10984618
16CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.08600083
17* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03357286
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03286860
19ESR1_15608294_ChIP-ChIP_MCF-7_Human2.00146585
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99610443
21ZFP281_27345836_Chip-Seq_ESCs_Mouse1.96899776
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.93205113
23KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91389366
24TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.91118953
25SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.89755865
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.87456070
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.83610847
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.83319805
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.79392036
30VDR_21846776_ChIP-Seq_THP-1_Human1.78312646
31DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.76027386
32CIITA_25753668_ChIP-Seq_RAJI_Human1.76001150
33TCF7_22412390_ChIP-Seq_EML_Mouse1.73636084
34CLOCK_20551151_ChIP-Seq_293T_Human1.65478292
35SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.65254588
36XRN2_22483619_ChIP-Seq_HELA_Human1.65026835
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.63119200
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.62617633
39P300_27058665_Chip-Seq_ZR-75-30cells_Human1.62274740
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61915511
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.61739647
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.59280834
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57846073
44KDM2B_26808549_Chip-Seq_JURKAT_Human1.57389305
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.56772835
46KDM2B_26808549_Chip-Seq_K562_Human1.54316224
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.53620317
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.51159848
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49405128
50DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.49308063
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.48008646
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47166446
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.45867855
54LXR_22292898_ChIP-Seq_THP-1_Human1.45626879
55ATF3_27146783_Chip-Seq_COLON_Human1.44140546
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43661869
57CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.43129056
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42725332
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42423396
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40511972
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.40057030
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.38563907
63EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.36570275
64AR_21909140_ChIP-Seq_LNCAP_Human1.36184509
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36130766
66NANOG_21062744_ChIP-ChIP_HESCs_Human1.35093444
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33334280
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32145196
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32102543
70PKCTHETA_26484144_Chip-Seq_BREAST_Human1.29859352
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.29215882
72CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28643928
73HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28593742
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27827551
75SMC4_20622854_ChIP-Seq_HELA_Human1.27816161
76CHD1_26751641_Chip-Seq_LNCaP_Human1.26868794
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26741032
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26411262
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25993969
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25696262
81* CREB1_26743006_Chip-Seq_LNCaP_Human1.25684628
82MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24476237
83THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23626874
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23354999
85SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21901299
86KDM5A_27292631_Chip-Seq_BREAST_Human1.21272005
87HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19453811
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18357334
89RACK7_27058665_Chip-Seq_MCF-7_Human1.18067340
90SALL1_21062744_ChIP-ChIP_HESCs_Human1.17449509
91MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17178955
92UTX_26944678_Chip-Seq_JUKART_Human1.16265812
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15962807
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15882419
95* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15333556
96NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14015961
97TRIM28_21343339_ChIP-Seq_HEK293_Human1.12804206
98FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.12083497
99TP53_22127205_ChIP-Seq_IMR90_Human1.12061268
100SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.11986602
101NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.11884336
102DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11881292
103STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11567852
104TP63_19390658_ChIP-ChIP_HaCaT_Human1.08521853
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07350219
106KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06781115
107SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05988908
108TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.04720743
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04602332
110NCOR1_26117541_ChIP-Seq_K562_Human1.04303377
111SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.03600067
112OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02445540
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02235838
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01317634
115P68_20966046_ChIP-Seq_HELA_Human1.00691412
116ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00613880
117RUNX1_27514584_Chip-Seq_MCF-7_Human1.00045584
118MYC_18358816_ChIP-ChIP_MESCs_Mouse0.99644408
119FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99621421
120PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99370815
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98958260
122CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98858545
123SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98807870
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98610408
125UBF1/2_26484160_Chip-Seq_HMECs_Human0.98585414
126MAF_26560356_Chip-Seq_TH1_Human0.98079852
127NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97785331
128DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97525024
129TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97430732
130SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97011349
131TET1_21490601_ChIP-Seq_MESCs_Mouse0.96890746
132RARB_27405468_Chip-Seq_BRAIN_Mouse0.95715482
133* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95094715
134NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94081264

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.47624816
2MP0010352_gastrointestinal_tract_polyps3.42132253
3MP0000537_abnormal_urethra_morphology3.20090095
4MP0005076_abnormal_cell_differentiation2.99726171
5MP0008438_abnormal_cutaneous_collagen2.44940675
6MP0003123_paternal_imprinting2.42334937
7MP0000569_abnormal_digit_pigmentation2.39779025
8MP0001730_embryonic_growth_arrest2.25418904
9MP0003111_abnormal_nucleus_morphology2.21447596
10MP0005451_abnormal_body_composition2.20325653
11MP0010234_abnormal_vibrissa_follicle2.13404434
12MP0005257_abnormal_intraocular_pressure2.06455925
13MP0010030_abnormal_orbit_morphology2.02276452
14MP0001849_ear_inflammation2.01378432
15MP0000566_synostosis2.00733349
16MP0002084_abnormal_developmental_patter1.99444743
17MP0004957_abnormal_blastocyst_morpholog1.99128819
18MP0000579_abnormal_nail_morphology1.98088070
19MP0002249_abnormal_larynx_morphology1.95943176
20MP0004859_abnormal_synaptic_plasticity1.94588902
21MP0004272_abnormal_basement_membrane1.93791959
22MP0003283_abnormal_digestive_organ1.91269572
23MP0008961_abnormal_basal_metabolism1.91246137
24MP0004233_abnormal_muscle_weight1.87836566
25MP0004197_abnormal_fetal_growth/weight/1.86001202
26MP0003119_abnormal_digestive_system1.85943339
27MP0005623_abnormal_meninges_morphology1.85775895
28MP0000350_abnormal_cell_proliferation1.84995415
29MP0002653_abnormal_ependyma_morphology1.84339953
30MP0005187_abnormal_penis_morphology1.81776658
31MP0003121_genomic_imprinting1.80442396
32MP0005409_darkened_coat_color1.79314363
33MP0004858_abnormal_nervous_system1.78186796
34MP0009053_abnormal_anal_canal1.76765297
35MP0002085_abnormal_embryonic_tissue1.74206465
36MP0003077_abnormal_cell_cycle1.72077169
37MP0001697_abnormal_embryo_size1.68438951
38MP0001346_abnormal_lacrimal_gland1.66963741
39MP0008260_abnormal_autophagy1.66371701
40MP0000733_abnormal_muscle_development1.65832132
41MP0005380_embryogenesis_phenotype1.64840264
42MP0001672_abnormal_embryogenesis/_devel1.64840264
43MP0000751_myopathy1.64783027
44MP0010094_abnormal_chromosome_stability1.64443894
45MP0003122_maternal_imprinting1.64323914
46MP0002088_abnormal_embryonic_growth/wei1.60420456
47MP0003984_embryonic_growth_retardation1.59864400
48MP0000678_abnormal_parathyroid_gland1.59847630
49MP0002796_impaired_skin_barrier1.57433327
50MP0010307_abnormal_tumor_latency1.51205204
51MP0002080_prenatal_lethality1.50872103
52MP0003115_abnormal_respiratory_system1.50691027
53MP0002086_abnormal_extraembryonic_tissu1.50254865
54MP0003861_abnormal_nervous_system1.50001040
55MP0003566_abnormal_cell_adhesion1.48592039
56MP0000428_abnormal_craniofacial_morphol1.47181678
57MP0002877_abnormal_melanocyte_morpholog1.47053515
58MP0002089_abnormal_postnatal_growth/wei1.46618517
59MP0003693_abnormal_embryo_hatching1.44132651
60MP0005058_abnormal_lysosome_morphology1.43316892
61MP0003890_abnormal_embryonic-extraembry1.42582674
62MP0003300_gastrointestinal_ulcer1.42520385
63MP0005501_abnormal_skin_physiology1.41633799
64MP0001348_abnormal_lacrimal_gland1.33621263
65MP0000762_abnormal_tongue_morphology1.31526540
66MP0003567_abnormal_fetal_cardiomyocyte1.31127878
67MP0000534_abnormal_ureter_morphology1.29767179
68MP0009278_abnormal_bone_marrow1.27992206
69MP0003091_abnormal_cell_migration1.26503314
70MP0000778_abnormal_nervous_system1.24651642
71MP0009672_abnormal_birth_weight1.23607091
72MP0003453_abnormal_keratinocyte_physiol1.22022099
73MP0004811_abnormal_neuron_physiology1.19882404
74MP0002909_abnormal_adrenal_gland1.18140710
75MP0004185_abnormal_adipocyte_glucose1.17154190
76MP0001299_abnormal_eye_distance/1.17057710
77MP0003385_abnormal_body_wall1.15857135
78MP0008932_abnormal_embryonic_tissue1.15744514
79MP0002060_abnormal_skin_morphology1.15520955
80MP0008007_abnormal_cellular_replicative1.13560786
81MP0000462_abnormal_digestive_system1.12298684
82MP0002098_abnormal_vibrissa_morphology1.11859595
83MP0003303_peritoneal_inflammation1.11329823
84MP0000467_abnormal_esophagus_morphology1.11313273
85MP0003935_abnormal_craniofacial_develop1.11299388
86MP0008770_decreased_survivor_rate1.10804891
87MP0002234_abnormal_pharynx_morphology1.09368383
88MP0004264_abnormal_extraembryonic_tissu1.08989021
89MP0002925_abnormal_cardiovascular_devel1.06585592
90MP0003942_abnormal_urinary_system1.05295602
91MP0002697_abnormal_eye_size1.01562449
92MP0009703_decreased_birth_body0.99883558
93MP0002822_catalepsy0.99838792
94MP0010630_abnormal_cardiac_muscle0.97081733
95MP0002184_abnormal_innervation0.96768607
96MP0005666_abnormal_adipose_tissue0.95839508
97MP0006054_spinal_hemorrhage0.95419768
98MP0000759_abnormal_skeletal_muscle0.95358170
99MP0003221_abnormal_cardiomyocyte_apopto0.94147332
100MP0001915_intracranial_hemorrhage0.93994096
101MP0002081_perinatal_lethality0.93685286
102MP0005248_abnormal_Harderian_gland0.93187684
103MP0002152_abnormal_brain_morphology0.93013099
104MP0000003_abnormal_adipose_tissue0.92817958
105MP0005394_taste/olfaction_phenotype0.91740456
106MP0005499_abnormal_olfactory_system0.91740456
107MP0009780_abnormal_chondrocyte_physiolo0.90509940
108MP0002092_abnormal_eye_morphology0.90425001
109MP0000747_muscle_weakness0.89794622
110MP0005508_abnormal_skeleton_morphology0.89119560
111MP0002896_abnormal_bone_mineralization0.88821044
112MP0000955_abnormal_spinal_cord0.87620868
113MP0008789_abnormal_olfactory_epithelium0.87345694
114MP0003634_abnormal_glial_cell0.87085267
115MP0001661_extended_life_span0.86738060
116MP0004808_abnormal_hematopoietic_stem0.85732028
117MP0002114_abnormal_axial_skeleton0.85295801
118MP0000750_abnormal_muscle_regeneration0.84793312
119MP0003279_aneurysm0.84670673
120MP0004084_abnormal_cardiac_muscle0.83970063
121MP0000377_abnormal_hair_follicle0.80953611
122MP0009384_cardiac_valve_regurgitation0.80607172
123MP0003329_amyloid_beta_deposits0.80475664
124MP0000432_abnormal_head_morphology0.79869687
125MP0005023_abnormal_wound_healing0.78962847
126MP0000266_abnormal_heart_morphology0.78861814
127MP0003315_abnormal_perineum_morphology0.78194671
128MP0001293_anophthalmia0.77730833
129MP0002396_abnormal_hematopoietic_system0.77242148
130MP0002111_abnormal_tail_morphology0.76119101
131MP0003937_abnormal_limbs/digits/tail_de0.76021641
132MP0003755_abnormal_palate_morphology0.75570547
133MP0002116_abnormal_craniofacial_bone0.73950783
134MP0002932_abnormal_joint_morphology0.70871600
135MP0005375_adipose_tissue_phenotype0.69853232
136MP0005621_abnormal_cell_physiology0.68518423
137MP0004087_abnormal_muscle_fiber0.68360584

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.72494285
2Premature rupture of membranes (HP:0001788)3.52944411
3Ependymoma (HP:0002888)3.33175693
4Astrocytoma (HP:0009592)3.28768271
5Abnormality of the astrocytes (HP:0100707)3.28768271
6Short 4th metacarpal (HP:0010044)3.27355590
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.27355590
8Ulnar bowing (HP:0003031)2.98894921
9Broad face (HP:0000283)2.96283196
10Shallow orbits (HP:0000586)2.89231355
11Abnormality of the lower motor neuron (HP:0002366)2.86831398
12Renal duplication (HP:0000075)2.85077265
13Insomnia (HP:0100785)2.83965426
14Distal lower limb amyotrophy (HP:0008944)2.77338753
15Pointed chin (HP:0000307)2.69845866
16Amyotrophic lateral sclerosis (HP:0007354)2.64381441
17Abnormality of the 4th metacarpal (HP:0010012)2.58376253
18Bowel diverticulosis (HP:0005222)2.56380451
19Hand muscle atrophy (HP:0009130)2.55862402
20Cerebral aneurysm (HP:0004944)2.54510819
21Increased nuchal translucency (HP:0010880)2.54142139
22Elfin facies (HP:0004428)2.53862734
23Heterotopia (HP:0002282)2.53800887
24Flat acetabular roof (HP:0003180)2.50375156
25Shoulder girdle muscle weakness (HP:0003547)2.48543692
26Overriding aorta (HP:0002623)2.47666403
27Pelvic girdle muscle weakness (HP:0003749)2.47057287
28Broad distal phalanx of finger (HP:0009836)2.44750917
29Neoplasm of the heart (HP:0100544)2.44694477
30Cortical dysplasia (HP:0002539)2.43621669
31Renovascular hypertension (HP:0100817)2.41384021
32Abnormality of the distal phalanx of the thumb (HP:0009617)2.40066709
33Protrusio acetabuli (HP:0003179)2.37351034
34Short nail (HP:0001799)2.37187222
35Macroorchidism (HP:0000053)2.36555313
36Glioma (HP:0009733)2.34041592
37Disproportionate tall stature (HP:0001519)2.33509003
38Upper limb amyotrophy (HP:0009129)2.30541573
39Distal upper limb amyotrophy (HP:0007149)2.30541573
40Cervical subluxation (HP:0003308)2.28574472
41Lower limb amyotrophy (HP:0007210)2.27916674
42Increased density of long bones (HP:0006392)2.23182052
43Trigonocephaly (HP:0000243)2.22860600
44Genu recurvatum (HP:0002816)2.21549792
45Vertebral compression fractures (HP:0002953)2.18539826
46Wrist flexion contracture (HP:0001239)2.18000162
47Spinal rigidity (HP:0003306)2.17706333
48Fibroma (HP:0010614)2.17697481
49Lymphangioma (HP:0100764)2.16580165
50Obstructive sleep apnea (HP:0002870)2.16443734
51Turricephaly (HP:0000262)2.14993916
52Abnormality of dentin (HP:0010299)2.14771363
53Abnormality of the labia minora (HP:0012880)2.14164530
54Arnold-Chiari malformation (HP:0002308)2.13322645
55Insidious onset (HP:0003587)2.12240651
56Termporal pattern (HP:0011008)2.12240651
57Adenoma sebaceum (HP:0009720)2.11193960
58Angiofibromas (HP:0010615)2.11193960
59Patellar dislocation (HP:0002999)2.11163311
60Subacute progressive viral hepatitis (HP:0006572)2.10672434
61Abnormality of the musculature of the pelvis (HP:0001469)2.09523135
62Abnormality of the hip-girdle musculature (HP:0001445)2.09523135
63Fibrous tissue neoplasm (HP:0012316)2.09073604
64Increased connective tissue (HP:0009025)2.08393833
65Sacral dimple (HP:0000960)2.08138836
66Centrally nucleated skeletal muscle fibers (HP:0003687)2.05331929
67Enlarged penis (HP:0000040)2.04741787
68High anterior hairline (HP:0009890)2.03964894
69Deep palmar crease (HP:0006191)2.03750400
70Mitral regurgitation (HP:0001653)2.03326543
71Ankle contracture (HP:0006466)2.03053798
72Megalocornea (HP:0000485)2.02747357
73Apathy (HP:0000741)2.02061943
74Bladder diverticulum (HP:0000015)2.02041104
75Fragile skin (HP:0001030)1.96841740
76Abnormality of the distal phalanges of the toes (HP:0010182)1.96162681
77Diminished motivation (HP:0000745)1.95775586
78Hallux valgus (HP:0001822)1.93936170
79Asymmetry of the thorax (HP:0001555)1.92842763
80Deviation of the hallux (HP:0010051)1.91743564
81Bronchomalacia (HP:0002780)1.91181952
82Advanced eruption of teeth (HP:0006288)1.90559671
83Premature skin wrinkling (HP:0100678)1.90389430
84Flat cornea (HP:0007720)1.90127015
85Broad palm (HP:0001169)1.88391078
86Atrophic scars (HP:0001075)1.87837532
87Overlapping toe (HP:0001845)1.86990649
88Mildly elevated creatine phosphokinase (HP:0008180)1.86472514
89Colon cancer (HP:0003003)1.85881824
90Achilles tendon contracture (HP:0001771)1.85858444
91Thin bony cortex (HP:0002753)1.84565107
92Back pain (HP:0003418)1.83724590
93Hammertoe (HP:0001765)1.80879327
94Increased variability in muscle fiber diameter (HP:0003557)1.80536453
95Cholecystitis (HP:0001082)1.80416736
96Abnormal gallbladder physiology (HP:0012438)1.80416736
97Gastrointestinal carcinoma (HP:0002672)1.79918098
98Malignant gastrointestinal tract tumors (HP:0006749)1.79918098
99Metaphyseal cupping (HP:0003021)1.79596784
100Trismus (HP:0000211)1.79512003
101Ankyloglossia (HP:0010296)1.78689932
102Abnormality of oral frenula (HP:0000190)1.78637785
103Selective tooth agenesis (HP:0001592)1.78595999
104Intellectual disability, profound (HP:0002187)1.77889354
105Dilatation of the ascending aorta (HP:0005111)1.77171479
106Aneurysm (HP:0002617)1.76800361
107Flattened epiphyses (HP:0003071)1.75996930
108Natal tooth (HP:0000695)1.75910805
109Medulloblastoma (HP:0002885)1.75612317
110Abnormality of the calcaneus (HP:0008364)1.75524371
111Biconcave vertebral bodies (HP:0004586)1.74138683
112Wormian bones (HP:0002645)1.73295186
113Abnormality of the phalanges of the hallux (HP:0010057)1.73216009
114Obsessive-compulsive behavior (HP:0000722)1.73007403
115Limb-girdle muscle atrophy (HP:0003797)1.71200178
116Pseudobulbar signs (HP:0002200)1.69783722
117Thin ribs (HP:0000883)1.69442063
118Congenital glaucoma (HP:0001087)1.68905586
119Blue sclerae (HP:0000592)1.68848115
120Distal lower limb muscle weakness (HP:0009053)1.68227793
121Neoplasm of striated muscle (HP:0009728)1.68185663
122Mitral valve prolapse (HP:0001634)1.67926210
123Dysmetric saccades (HP:0000641)1.67042189
124Facial hemangioma (HP:0000329)1.66784277
125Cerebral inclusion bodies (HP:0100314)1.66522041
126Abnormal ossification of hand bones (HP:0005921)1.65772161
127Vertebral arch anomaly (HP:0008438)1.65560383
128Broad thumb (HP:0011304)1.64889147
129Hyperparathyroidism (HP:0000843)1.63376005
130Urinary urgency (HP:0000012)1.63105196
131Long palpebral fissure (HP:0000637)1.62655247
132Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.62532021
133Generalized hypotonia (HP:0001290)1.61762000
134Sparse lateral eyebrow (HP:0005338)1.61296348
135Joint laxity (HP:0001388)1.61240935
136Rectal prolapse (HP:0002035)1.60836743
137Intestinal polyp (HP:0005266)1.60819139
138Neoplasm of the oral cavity (HP:0100649)1.60768948
139Broad metatarsal (HP:0001783)1.60410617
140Relative macrocephaly (HP:0004482)1.60141205
141Leiomyosarcoma (HP:0100243)1.59831960
142Uterine leiomyosarcoma (HP:0002891)1.59831960
143Abnormality of the aortic arch (HP:0012303)1.59426154
144Hepatoblastoma (HP:0002884)1.59266819
145Abnormality of the diencephalon (HP:0010662)1.59194541
146Difficulty climbing stairs (HP:0003551)1.58955524
147Spina bifida occulta (HP:0003298)1.58896240
148Long eyelashes (HP:0000527)1.58566892
149Midface retrusion (HP:0011800)1.58389155
150Annular pancreas (HP:0001734)1.57698510
151Rhizomelia (HP:0008905)1.57435407
152* Deviation of the thumb (HP:0009603)1.57259515
153Exostoses (HP:0100777)1.56780857
154Cutis marmorata (HP:0000965)1.56655379
155Abnormality of the Achilles tendon (HP:0005109)1.56589563
156Aplasia involving bones of the upper limbs (HP:0009823)1.55318359
157Aplasia of the phalanges of the hand (HP:0009802)1.55318359
158Aplasia involving bones of the extremities (HP:0009825)1.55318359
159Missing ribs (HP:0000921)1.55201678
160Precocious puberty (HP:0000826)1.55108772
161Attention deficit hyperactivity disorder (HP:0007018)1.55036749
162Basal cell carcinoma (HP:0002671)1.54559165

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.99693536
2EEF2K3.98295467
3SMG13.88368009
4PKN23.46153138
5CDK122.89964130
6MAP3K102.63203179
7PRPF4B2.61747039
8MARK12.58695420
9SCYL22.30884120
10NEK12.23724303
11MAP3K92.10593122
12LATS22.01950439
13KSR11.97198032
14ALK1.95826388
15PDGFRA1.92137730
16CDC71.87751795
17IRAK31.85149726
18ICK1.60166077
19TYRO31.59013197
20TSSK61.57367300
21TTN1.52347794
22TESK21.52185169
23KSR21.48751996
24PAK61.45475678
25PASK1.43172059
26RIPK11.42687776
27PTK61.40362137
28LMTK21.40147332
29NEK21.39812846
30MTOR1.31836287
31MINK11.30452229
32MST1R1.22902637
33EPHB11.21952904
34NME21.20453652
35RET1.17807716
36PRKD31.15394933
37FGFR11.13123309
38PAK41.12941240
39TAOK21.07098445
40ARAF1.05114849
41TESK11.04870413
42RPS6KB21.04862389
43EPHB21.04542844
44PAK21.02083977
45LIMK11.00943242
46TGFBR10.99896920
47TAOK10.99250057
48BRD40.92860331
49LRRK20.89463845
50SIK20.89384674
51MET0.86802802
52CDK60.85172855
53NTRK20.85091223
54FER0.84153394
55MAP3K80.83751979
56FGFR40.82591756
57PTK20.81519833
58PRKD20.79623962
59UHMK10.79607125
60PAK30.77842677
61EIF2AK10.77544955
62CDK140.76441596
63CDK40.75588221
64DDR20.73807822
65SIK10.73245797
66CDK180.73154812
67CDK150.73071368
68CHEK10.72493598
69BMX0.71049666
70DYRK20.70665677
71FGFR30.69448297
72PNCK0.69240806
73BRAF0.67595370
74LATS10.67398490
75MAP3K40.66734289
76CDK11A0.66261952
77CAMKK10.65551824
78ERBB20.65523153
79CDK20.64845660
80FGFR20.64508441
81CAMK1G0.64360709
82EPHA30.64269209
83PDGFRB0.63912301
84EPHA20.63500718
85MAP3K60.62778791
86PLK30.62197654
87NTRK10.60625600
88CSNK1E0.59106411
89ATR0.58881430
90CAMK1D0.56726041
91AURKA0.56691499
92ILK0.55979152
93BRSK10.55401119
94CDK90.55320827
95TTK0.55215775
96DYRK1B0.53153453
97BUB10.52663173
98RPS6KA20.51880396
99RPS6KC10.50106121
100RPS6KL10.50106121
101CDK70.48255066
102STK100.47948605
103CSNK1G20.47666594
104MAPK90.47311079
105MAP2K30.47215577
106PDPK10.46309194
107ERN10.45742143
108DMPK0.45432646
109CSNK1D0.45368319
110PLK10.45245550
111MAP3K110.45007862
112MAP2K20.44876516
113* CDK10.44847073
114PIM20.44439496
115CDC42BPA0.44231343
116VRK20.43992731
117SIK30.43874602
118MARK20.42927994
119WEE10.41748739
120IRAK20.41564376
121MAP3K20.41290764
122PAK10.40067665
123PRKDC0.39717843
124CSNK1A1L0.39276596
125CHEK20.38761664
126AKT20.38712382
127MAP3K130.38481899
128MAP3K10.36125179
129MAPK110.34863308
130SRPK10.32044335
131MAPK100.31949236
132MOS0.31488775
133STK380.30482529
134ROCK20.28833455

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01382078
2Chronic myeloid leukemia_Homo sapiens_hsa052201.90953484
3mTOR signaling pathway_Homo sapiens_hsa041501.86500449
4RNA transport_Homo sapiens_hsa030131.84839535
5Pentose phosphate pathway_Homo sapiens_hsa000301.84836850
6Colorectal cancer_Homo sapiens_hsa052101.81455645
7Endometrial cancer_Homo sapiens_hsa052131.78834659
8mRNA surveillance pathway_Homo sapiens_hsa030151.73610990
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67695994
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.66365278
11Central carbon metabolism in cancer_Homo sapiens_hsa052301.64142965
12Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.62473095
13Glioma_Homo sapiens_hsa052141.58831698
14Hippo signaling pathway_Homo sapiens_hsa043901.56000486
15Cell cycle_Homo sapiens_hsa041101.55782760
16Oocyte meiosis_Homo sapiens_hsa041141.52332523
17Fructose and mannose metabolism_Homo sapiens_hsa000511.49953654
18Neurotrophin signaling pathway_Homo sapiens_hsa047221.47455563
19Thyroid hormone signaling pathway_Homo sapiens_hsa049191.45731260
20MicroRNAs in cancer_Homo sapiens_hsa052061.45706279
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43805401
22Non-small cell lung cancer_Homo sapiens_hsa052231.43452917
23Spliceosome_Homo sapiens_hsa030401.42986301
24Viral myocarditis_Homo sapiens_hsa054161.42625069
25Prion diseases_Homo sapiens_hsa050201.39107242
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.38403452
27Adherens junction_Homo sapiens_hsa045201.37031559
28Bladder cancer_Homo sapiens_hsa052191.33500617
29VEGF signaling pathway_Homo sapiens_hsa043701.33115236
30Renal cell carcinoma_Homo sapiens_hsa052111.32892488
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.32657195
32Vibrio cholerae infection_Homo sapiens_hsa051101.30805364
33* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30175446
34Basal cell carcinoma_Homo sapiens_hsa052171.30152672
35Proteoglycans in cancer_Homo sapiens_hsa052051.27694085
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.27419286
37Notch signaling pathway_Homo sapiens_hsa043301.27171424
38Thyroid cancer_Homo sapiens_hsa052161.24579999
39Estrogen signaling pathway_Homo sapiens_hsa049151.24125009
40Galactose metabolism_Homo sapiens_hsa000521.20591838
41Pancreatic cancer_Homo sapiens_hsa052121.18046713
42DNA replication_Homo sapiens_hsa030301.16499054
43Carbon metabolism_Homo sapiens_hsa012001.16332361
44One carbon pool by folate_Homo sapiens_hsa006701.16100950
45Other glycan degradation_Homo sapiens_hsa005111.14318739
46Gap junction_Homo sapiens_hsa045401.13570485
47Axon guidance_Homo sapiens_hsa043601.12591854
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11170249
49HTLV-I infection_Homo sapiens_hsa051661.10364306
50Viral carcinogenesis_Homo sapiens_hsa052031.05468815
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05350336
52ErbB signaling pathway_Homo sapiens_hsa040121.04384610
53Focal adhesion_Homo sapiens_hsa045101.04340994
54Insulin signaling pathway_Homo sapiens_hsa049101.03526629
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03494841
56Hedgehog signaling pathway_Homo sapiens_hsa043401.01067741
57Small cell lung cancer_Homo sapiens_hsa052220.98395250
58ECM-receptor interaction_Homo sapiens_hsa045120.97283184
59AMPK signaling pathway_Homo sapiens_hsa041520.95719098
60Acute myeloid leukemia_Homo sapiens_hsa052210.95042465
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92678977
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92578445
63Tight junction_Homo sapiens_hsa045300.90926067
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89628427
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89533700
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89516063
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89230280
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89088738
69Long-term potentiation_Homo sapiens_hsa047200.88301600
70Wnt signaling pathway_Homo sapiens_hsa043100.88125578
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87699878
72Dorso-ventral axis formation_Homo sapiens_hsa043200.87410125
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87176791
74Lysine degradation_Homo sapiens_hsa003100.86831183
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85631962
76Type II diabetes mellitus_Homo sapiens_hsa049300.84822219
77Prolactin signaling pathway_Homo sapiens_hsa049170.84489265
78HIF-1 signaling pathway_Homo sapiens_hsa040660.83953936
79Dopaminergic synapse_Homo sapiens_hsa047280.82139219
80Endocytosis_Homo sapiens_hsa041440.81950649
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.81510489
82Amoebiasis_Homo sapiens_hsa051460.79866488
83Inositol phosphate metabolism_Homo sapiens_hsa005620.79356472
84p53 signaling pathway_Homo sapiens_hsa041150.77932714
85Shigellosis_Homo sapiens_hsa051310.76634153
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76309350
87Melanogenesis_Homo sapiens_hsa049160.75793736
88Synaptic vesicle cycle_Homo sapiens_hsa047210.73577050
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.72591891
90Prostate cancer_Homo sapiens_hsa052150.72459321
91Pathways in cancer_Homo sapiens_hsa052000.72125132
92Insulin resistance_Homo sapiens_hsa049310.71526426
93TGF-beta signaling pathway_Homo sapiens_hsa043500.71100974
94Biosynthesis of amino acids_Homo sapiens_hsa012300.71061751
95Dilated cardiomyopathy_Homo sapiens_hsa054140.71052470
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70374472
97GnRH signaling pathway_Homo sapiens_hsa049120.70280580
98Mismatch repair_Homo sapiens_hsa034300.69689471
99T cell receptor signaling pathway_Homo sapiens_hsa046600.69601326
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69434136
101Sulfur relay system_Homo sapiens_hsa041220.69303150
102Epstein-Barr virus infection_Homo sapiens_hsa051690.68627202
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67839008
104Rap1 signaling pathway_Homo sapiens_hsa040150.67606387
105Hepatitis B_Homo sapiens_hsa051610.66027539
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65807665
107Apoptosis_Homo sapiens_hsa042100.65721406
108Glucagon signaling pathway_Homo sapiens_hsa049220.64666270
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.63276795
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62616152
111Base excision repair_Homo sapiens_hsa034100.62387266
112Salmonella infection_Homo sapiens_hsa051320.61307732
113Hepatitis C_Homo sapiens_hsa051600.61266543
114Melanoma_Homo sapiens_hsa052180.60647748
115Oxytocin signaling pathway_Homo sapiens_hsa049210.60420472
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60217640
117N-Glycan biosynthesis_Homo sapiens_hsa005100.59769971
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.59688328
119FoxO signaling pathway_Homo sapiens_hsa040680.58399619
120Alcoholism_Homo sapiens_hsa050340.58335982
121MAPK signaling pathway_Homo sapiens_hsa040100.58252224
122Choline metabolism in cancer_Homo sapiens_hsa052310.57307698
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.57283285
124Cholinergic synapse_Homo sapiens_hsa047250.56804304
125Steroid biosynthesis_Homo sapiens_hsa001000.56221415

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