UBA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been identified on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exocrine pancreas development (GO:0031017)5.85428767
2signal peptide processing (GO:0006465)5.50572714
3protein maturation by protein folding (GO:0022417)5.05081493
4positive regulation of growth hormone secretion (GO:0060124)4.84543065
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.74438596
6pseudouridine synthesis (GO:0001522)4.70094375
7ER overload response (GO:0006983)4.64987542
8protein retention in ER lumen (GO:0006621)4.36708416
9COPI coating of Golgi vesicle (GO:0048205)4.30110559
10Golgi transport vesicle coating (GO:0048200)4.30110559
11chemosensory behavior (GO:0007635)4.23447824
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.93742676
13regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.86366215
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.84620181
15regulation of mitotic spindle organization (GO:0060236)3.76058155
16endocrine pancreas development (GO:0031018)3.72463552
17DNA damage response, detection of DNA damage (GO:0042769)3.71670982
18negative regulation of smooth muscle cell differentiation (GO:0051151)3.68504812
19digestion (GO:0007586)3.64784964
20ATP synthesis coupled proton transport (GO:0015986)3.61504709
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.61504709
22glandular epithelial cell differentiation (GO:0002067)3.60091670
23histone H2B ubiquitination (GO:0033523)3.58616873
24dopamine biosynthetic process (GO:0042416)3.57000137
25peptide hormone processing (GO:0016486)3.37115175
26positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.36017709
27mitotic metaphase plate congression (GO:0007080)3.34525558
28single strand break repair (GO:0000012)3.31278980
29intestinal cholesterol absorption (GO:0030299)3.30766485
30regulation of growth hormone secretion (GO:0060123)3.26293832
31sequestering of metal ion (GO:0051238)3.23625775
32keratinocyte development (GO:0003334)3.18752128
33regulation of pigment cell differentiation (GO:0050932)3.16871969
34neuron cell-cell adhesion (GO:0007158)3.16482912
35detection of calcium ion (GO:0005513)3.15904366
36growth hormone secretion (GO:0030252)3.15639721
37GDP-mannose metabolic process (GO:0019673)3.15119549
38pyrimidine-containing compound transmembrane transport (GO:0072531)3.10647842
39dopamine transport (GO:0015872)3.10430508
40branching involved in prostate gland morphogenesis (GO:0060442)3.09083925
41regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.08424288
42lung secretory cell differentiation (GO:0061140)3.05624248
43epithelial cell maturation (GO:0002070)3.05149372
44GTP biosynthetic process (GO:0006183)3.04361856
45COPII vesicle coating (GO:0048208)3.04196595
46SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)3.01896738
47protein localization to Golgi apparatus (GO:0034067)3.00200408
48face development (GO:0060324)3.00080426
49cellular response to ATP (GO:0071318)2.98137540
50zinc ion transport (GO:0006829)2.97770199
51presynaptic membrane assembly (GO:0097105)2.97025033
52regulation of catecholamine metabolic process (GO:0042069)2.95989125
53regulation of dopamine metabolic process (GO:0042053)2.95989125
54glycolipid catabolic process (GO:0019377)2.94821942
55DNA double-strand break processing (GO:0000729)2.94442420
56respiratory electron transport chain (GO:0022904)2.93429719
57sister chromatid cohesion (GO:0007062)2.93069817
58regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.91939772
59positive regulation of response to oxidative stress (GO:1902884)2.91103829
60positive regulation of cellular response to oxidative stress (GO:1900409)2.91103829
61mitotic sister chromatid cohesion (GO:0007064)2.89469932
62electron transport chain (GO:0022900)2.89359757
63nucleotide transmembrane transport (GO:1901679)2.86606716
64negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.85591301
65protein complex biogenesis (GO:0070271)2.83914501
66positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.83666604
67neuron recognition (GO:0008038)2.82093352
68histone H2A monoubiquitination (GO:0035518)2.79515090
69sensory perception of smell (GO:0007608)2.79294666
70inner ear receptor cell development (GO:0060119)2.79166013
71ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.75719243
72neuron remodeling (GO:0016322)2.75610452
73ceramide catabolic process (GO:0046514)2.74603194
74regulation of DNA damage checkpoint (GO:2000001)2.73937299
75regulation of oxidative phosphorylation (GO:0002082)2.70517639
76neural tube formation (GO:0001841)2.69949628
77nucleoside diphosphate catabolic process (GO:0009134)2.69299593
78histone ubiquitination (GO:0016574)2.68892400
79outer ear morphogenesis (GO:0042473)2.68804607
80protein N-linked glycosylation via asparagine (GO:0018279)2.68538803
81positive regulation of glycoprotein metabolic process (GO:1903020)2.67150243
82monoamine transport (GO:0015844)2.66001728
83activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.65385224
84positive regulation of glycoprotein biosynthetic process (GO:0010560)2.63808298
85ribonucleoprotein complex disassembly (GO:0032988)2.63733891
86nuclear pore complex assembly (GO:0051292)2.62502232
87positive regulation of histone methylation (GO:0031062)2.61653649
88negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.61152906
89mitochondrial calcium ion transport (GO:0006851)2.60740495
90regulation of spindle organization (GO:0090224)2.60377966
91peptidyl-asparagine modification (GO:0018196)2.60092468
92catechol-containing compound biosynthetic process (GO:0009713)2.58408225
93catecholamine biosynthetic process (GO:0042423)2.58408225
94aggressive behavior (GO:0002118)2.56008704
95cAMP-mediated signaling (GO:0019933)2.55977267
96respiratory chain complex IV assembly (GO:0008535)2.55711363
97negative regulation of execution phase of apoptosis (GO:1900118)2.55521955
98presynaptic membrane organization (GO:0097090)2.55306202
99mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.54845198
100mitochondrial respiratory chain complex I assembly (GO:0032981)2.54845198
101NADH dehydrogenase complex assembly (GO:0010257)2.54845198
102activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.54540821
103guanosine-containing compound biosynthetic process (GO:1901070)2.54090301
104retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.54087540
105regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.52924213
106protein N-linked glycosylation (GO:0006487)2.52740541
107histone monoubiquitination (GO:0010390)2.52727734
108cell morphogenesis involved in neuron differentiation (GO:0048667)2.52211914
109regulation of type B pancreatic cell apoptotic process (GO:2000674)2.51514634
110positive regulation of dendritic spine morphogenesis (GO:0061003)2.51039857
111response to nitrosative stress (GO:0051409)2.51037806
112fucose metabolic process (GO:0006004)2.49288063
113postsynaptic membrane organization (GO:0001941)2.48461147
114post-embryonic morphogenesis (GO:0009886)2.48186086
115multicellular organismal aging (GO:0010259)2.45614694
116startle response (GO:0001964)2.45284286
117fucosylation (GO:0036065)2.44629693
118catecholamine transport (GO:0051937)2.43095432
119regulation of neuron projection regeneration (GO:0070570)2.42881975
120regulation of axon regeneration (GO:0048679)2.42881975
121metaphase plate congression (GO:0051310)2.42373035
122cytochrome complex assembly (GO:0017004)2.41585562
123histone H2A ubiquitination (GO:0033522)2.41530155
124magnesium ion transport (GO:0015693)2.41387800
125positive regulation of nuclease activity (GO:0032075)2.40467616
126CENP-A containing nucleosome assembly (GO:0034080)2.40041320
127intraciliary transport (GO:0042073)2.39873045
128histone H2A acetylation (GO:0043968)2.39590676
129mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.38951228
130positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.38951228
131phenylpropanoid metabolic process (GO:0009698)2.38300451
132neuronal action potential propagation (GO:0019227)2.38200984
133fucose catabolic process (GO:0019317)2.37231617
134L-fucose metabolic process (GO:0042354)2.37231617
135L-fucose catabolic process (GO:0042355)2.37231617
136protein localization to cilium (GO:0061512)2.37126571
137developmental pigmentation (GO:0048066)2.36546469
138regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.36321769
139membrane lipid catabolic process (GO:0046466)2.36185980
140toxin metabolic process (GO:0009404)2.35942113
141transcytosis (GO:0045056)2.34803481
142nuclear pore organization (GO:0006999)2.34616654
143axoneme assembly (GO:0035082)2.34269999
144termination of RNA polymerase II transcription (GO:0006369)2.34057137
145ionotropic glutamate receptor signaling pathway (GO:0035235)2.32933571
146behavioral response to ethanol (GO:0048149)2.32706252
147short-term memory (GO:0007614)2.32482073
148glutamate receptor signaling pathway (GO:0007215)2.32420457
149glucosamine-containing compound catabolic process (GO:1901072)2.32050827
150regulation of beta-amyloid formation (GO:1902003)2.31283243
151cilium or flagellum-dependent cell motility (GO:0001539)2.30828773
152regulation of acyl-CoA biosynthetic process (GO:0050812)2.25298405
153chromatin remodeling at centromere (GO:0031055)2.24113410
154cellular glucuronidation (GO:0052695)2.23480978
155cilium morphogenesis (GO:0060271)2.21547694
156establishment of melanosome localization (GO:0032401)2.19226505
157melanosome transport (GO:0032402)2.18180659
158positive regulation of protein depolymerization (GO:1901881)2.17670126
159negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.17191796
160histone exchange (GO:0043486)2.17066059
161gene silencing by RNA (GO:0031047)2.16792311
162positive regulation of DNA-templated transcription, elongation (GO:0032786)2.15976037
163positive regulation of microtubule polymerization (GO:0031116)2.15585826
164regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.15106818
165mitotic chromosome condensation (GO:0007076)2.14951956
166proteasome assembly (GO:0043248)2.14612535
167DNA catabolic process, exonucleolytic (GO:0000738)2.13861845
168peristalsis (GO:0030432)2.13683767
169uronic acid metabolic process (GO:0006063)2.13150190
170glucuronate metabolic process (GO:0019585)2.13150190
171regulation of coenzyme metabolic process (GO:0051196)2.12140773
172regulation of cofactor metabolic process (GO:0051193)2.12140773
173sister chromatid segregation (GO:0000819)2.11531524
174positive regulation of mitochondrial fission (GO:0090141)2.11393236
175regulation of centriole replication (GO:0046599)2.10580265
176ATP-dependent chromatin remodeling (GO:0043044)2.10574277
177regulation of transcription from RNA polymerase I promoter (GO:0006356)2.10469344
178negative regulation of DNA repair (GO:0045738)2.10332635
179mitochondrial RNA metabolic process (GO:0000959)2.09865998
180RNA polyadenylation (GO:0043631)2.09786098
181regulation of DNA endoreduplication (GO:0032875)2.09629866
182lateral ventricle development (GO:0021670)2.09518987
183lateral sprouting from an epithelium (GO:0060601)2.08993094
184mRNA 3-end processing (GO:0031124)2.08268878
185regulation of hexokinase activity (GO:1903299)2.07943492
186regulation of glucokinase activity (GO:0033131)2.07943492
187embryonic epithelial tube formation (GO:0001838)2.07332405
188positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.06287323
189negative regulation of signal transduction by p53 class mediator (GO:1901797)2.06148916
190morphogenesis of an epithelial sheet (GO:0002011)2.05679373
191ribosomal large subunit biogenesis (GO:0042273)2.05338985
192positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.05276693
193transcription from mitochondrial promoter (GO:0006390)2.04664067
194detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.03780994
195mRNA cleavage (GO:0006379)2.03014034
196nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.01116587
197mRNA polyadenylation (GO:0006378)2.00900878

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.27667228
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.16742462
3GBX2_23144817_ChIP-Seq_PC3_Human3.81265114
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.54592554
5EWS_26573619_Chip-Seq_HEK293_Human3.11586120
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.54399560
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52343892
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.48629477
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44257558
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.42970785
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29881272
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.25813841
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25517309
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.24728874
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22982614
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.21491830
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.19860826
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.19241382
19TAF15_26573619_Chip-Seq_HEK293_Human2.14460477
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.14438429
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07890420
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05027637
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04190689
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02500611
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92113170
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.83771534
27ZNF274_21170338_ChIP-Seq_K562_Hela1.83452104
28P300_19829295_ChIP-Seq_ESCs_Human1.82820948
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81977902
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79796809
31* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77418783
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75962330
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.74500376
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74323819
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72522258
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72522258
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68117573
38VDR_22108803_ChIP-Seq_LS180_Human1.67418011
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65937777
40ELK1_19687146_ChIP-ChIP_HELA_Human1.65128489
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62430531
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.62364303
43AR_21572438_ChIP-Seq_LNCaP_Human1.57460213
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57051083
45RNF2_27304074_Chip-Seq_NSC_Mouse1.55949781
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54486966
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53135330
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.52416149
49PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.51068056
50MYC_18555785_ChIP-Seq_MESCs_Mouse1.50391150
51REST_21632747_ChIP-Seq_MESCs_Mouse1.50075742
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49837819
53IGF1R_20145208_ChIP-Seq_DFB_Human1.47687901
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46675927
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46091827
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43401616
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42966132
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40052578
59TP53_18474530_ChIP-ChIP_U2OS_Human1.39030769
60SMAD4_21799915_ChIP-Seq_A2780_Human1.37687484
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37546783
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34774476
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34754826
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.34502731
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33679095
66IRF1_19129219_ChIP-ChIP_H3396_Human1.33516113
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33100428
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32865982
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.32510632
70FUS_26573619_Chip-Seq_HEK293_Human1.31387257
71* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30463867
72DCP1A_22483619_ChIP-Seq_HELA_Human1.28594655
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28436723
74CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27330963
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27329604
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26833836
77E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26695843
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26373825
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26202801
80REST_19997604_ChIP-ChIP_NEURONS_Mouse1.25598538
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.25575497
82RUNX2_22187159_ChIP-Seq_PCA_Human1.24951557
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24951443
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23796287
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21552343
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21249709
87ER_23166858_ChIP-Seq_MCF-7_Human1.21203967
88AR_25329375_ChIP-Seq_VCAP_Human1.19903895
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19460316
90CBP_20019798_ChIP-Seq_JUKART_Human1.19460316
91FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19371200
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19005791
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17717258
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16705623
95EST1_17652178_ChIP-ChIP_JURKAT_Human1.15937232
96HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15232754
97P53_22387025_ChIP-Seq_ESCs_Mouse1.14532634
98CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14468946
99ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13532511
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12626976
101BCAT_22108803_ChIP-Seq_LS180_Human1.12367334
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11912494
103ERG_21242973_ChIP-ChIP_JURKAT_Human1.11824688
104STAT3_18555785_Chip-Seq_ESCs_Mouse1.11217297
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11061809
106BP1_19119308_ChIP-ChIP_Hs578T_Human1.09932887
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08943466
108NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08943466
109TAL1_26923725_Chip-Seq_HPCs_Mouse1.08704542
110SMAD4_21741376_ChIP-Seq_EPCs_Human1.08339623
111E2F1_18555785_Chip-Seq_ESCs_Mouse1.08058018
112SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08057744
113EZH2_27294783_Chip-Seq_NPCs_Mouse1.07156345
114CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07150436
115SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06972477
116FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06631891
117VDR_23849224_ChIP-Seq_CD4+_Human1.06552285
118EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05101319
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04432119
120YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03992325
121SOX2_18555785_Chip-Seq_ESCs_Mouse1.03623833
122FLI1_27457419_Chip-Seq_LIVER_Mouse1.03467473
123CMYC_18555785_Chip-Seq_ESCs_Mouse1.03444323
124WT1_19549856_ChIP-ChIP_CCG9911_Human1.03070734
125POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02647480
126FLI1_21867929_ChIP-Seq_TH2_Mouse1.02510214
127CDX2_22108803_ChIP-Seq_LS180_Human1.01956417
128AR_21909140_ChIP-Seq_LNCAP_Human1.00904733
129TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00206795
130NMYC_18555785_Chip-Seq_ESCs_Mouse0.99125267
131* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98969026
132TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98707727
133SOX9_26525672_Chip-Seq_HEART_Mouse0.98391337
134TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98211858
135TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97828871
136STAT3_23295773_ChIP-Seq_U87_Human0.97218762
137PHF8_20622853_ChIP-Seq_HELA_Human0.96937606
138JUN_21703547_ChIP-Seq_K562_Human0.96632301
139TP53_22573176_ChIP-Seq_HFKS_Human0.95654966
140CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95587312
141P300_18555785_Chip-Seq_ESCs_Mouse0.95480789
142TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94982931
143PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94662305
144RUNX1_27457419_Chip-Seq_LIVER_Mouse0.94220654
145TBL1_22424771_ChIP-Seq_293T_Human0.93868117
146PRDM14_20953172_ChIP-Seq_ESCs_Human0.93236262
147E2F1_21310950_ChIP-Seq_MCF-7_Human0.92793682
148NOTCH1_21737748_ChIP-Seq_TLL_Human0.92258348
149CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92002213
150YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91808710
151TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91659602
152CRX_20693478_ChIP-Seq_RETINA_Mouse0.91422803

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.57906179
2MP0010386_abnormal_urinary_bladder3.84538205
3MP0006276_abnormal_autonomic_nervous2.88852705
4MP0005220_abnormal_exocrine_pancreas2.86354948
5MP0003567_abnormal_fetal_cardiomyocyte2.82775254
6MP0005379_endocrine/exocrine_gland_phen2.78447063
7MP0002693_abnormal_pancreas_physiology2.76760536
8MP0009379_abnormal_foot_pigmentation2.47335268
9MP0001666_abnormal_nutrient_absorption2.36022954
10MP0004270_analgesia2.33605498
11MP0001188_hyperpigmentation2.30529315
12MP0003868_abnormal_feces_composition2.26536822
13MP0001501_abnormal_sleep_pattern2.15167985
14MP0001944_abnormal_pancreas_morphology2.14544230
15MP0003122_maternal_imprinting2.09644890
16MP0008058_abnormal_DNA_repair2.01619139
17MP0000013_abnormal_adipose_tissue1.90062883
18MP0002736_abnormal_nociception_after1.89858447
19MP0004043_abnormal_pH_regulation1.87646413
20MP0002234_abnormal_pharynx_morphology1.86234201
21MP0002233_abnormal_nose_morphology1.85618049
22MP0001968_abnormal_touch/_nociception1.85179839
23MP0008789_abnormal_olfactory_epithelium1.85088780
24MP0002277_abnormal_respiratory_mucosa1.82215504
25MP0000537_abnormal_urethra_morphology1.79920700
26MP0002938_white_spotting1.79725666
27MP0001905_abnormal_dopamine_level1.77798102
28MP0002837_dystrophic_cardiac_calcinosis1.76787391
29MP0003890_abnormal_embryonic-extraembry1.76347315
30MP0005394_taste/olfaction_phenotype1.75250666
31MP0005499_abnormal_olfactory_system1.75250666
32MP0001664_abnormal_digestion1.74736876
33MP0002876_abnormal_thyroid_physiology1.72392578
34MP0009780_abnormal_chondrocyte_physiolo1.71666631
35MP0005645_abnormal_hypothalamus_physiol1.70833782
36MP0005409_darkened_coat_color1.68647391
37MP0003195_calcinosis1.68629051
38MP0003635_abnormal_synaptic_transmissio1.68537697
39MP0002909_abnormal_adrenal_gland1.65972251
40MP0001984_abnormal_olfaction1.60993620
41MP0002734_abnormal_mechanical_nocicepti1.59959795
42MP0003959_abnormal_lean_body1.59483561
43MP0004957_abnormal_blastocyst_morpholog1.55681336
44MP0004145_abnormal_muscle_electrophysio1.54788798
45MP0000681_abnormal_thyroid_gland1.53997777
46MP0003221_abnormal_cardiomyocyte_apopto1.53150254
47MP0009745_abnormal_behavioral_response1.52949988
48MP0005423_abnormal_somatic_nervous1.48488928
49MP0004147_increased_porphyrin_level1.48228166
50MP0002163_abnormal_gland_morphology1.45899304
51MP0002572_abnormal_emotion/affect_behav1.45332707
52MP0005084_abnormal_gallbladder_morpholo1.43862626
53MP0005083_abnormal_biliary_tract1.41806086
54MP0009697_abnormal_copulation1.40744234
55MP0000613_abnormal_salivary_gland1.39987860
56MP0002160_abnormal_reproductive_system1.39561634
57MP0005187_abnormal_penis_morphology1.39400417
58MP0003315_abnormal_perineum_morphology1.37312513
59MP0005365_abnormal_bile_salt1.37112723
60MP0002272_abnormal_nervous_system1.36655289
61MP0003693_abnormal_embryo_hatching1.36396786
62MP0005535_abnormal_body_temperature1.35256092
63MP0008877_abnormal_DNA_methylation1.34982316
64MP0003136_yellow_coat_color1.34842923
65MP0002063_abnormal_learning/memory/cond1.33084386
66MP0003937_abnormal_limbs/digits/tail_de1.31707985
67MP0003718_maternal_effect1.31393698
68MP0000538_abnormal_urinary_bladder1.30997414
69MP0004133_heterotaxia1.30601272
70MP0003283_abnormal_digestive_organ1.30475981
71MP0001730_embryonic_growth_arrest1.30183488
72MP0000631_abnormal_neuroendocrine_gland1.29936665
73MP0005646_abnormal_pituitary_gland1.29571629
74MP0002067_abnormal_sensory_capabilities1.29527780
75MP0001440_abnormal_grooming_behavior1.28067242
76MP0001486_abnormal_startle_reflex1.27029200
77MP0002064_seizures1.26908720
78MP0002733_abnormal_thermal_nociception1.25406979
79MP0006072_abnormal_retinal_apoptosis1.25258062
80MP0002184_abnormal_innervation1.23569910
81MP0001529_abnormal_vocalization1.22607251
82MP0003385_abnormal_body_wall1.20787249
83MP0004742_abnormal_vestibular_system1.19816441
84MP0001970_abnormal_pain_threshold1.19608268
85MP0000778_abnormal_nervous_system1.18625899
86MP0005171_absent_coat_pigmentation1.15914415
87MP0002078_abnormal_glucose_homeostasis1.14715399
88MP0003119_abnormal_digestive_system1.14102900
89MP0005367_renal/urinary_system_phenotyp1.13212997
90MP0000516_abnormal_urinary_system1.13212997
91MP0003183_abnormal_peptide_metabolism1.12180995
92MP0000566_synostosis1.10376834
93MP0006292_abnormal_olfactory_placode1.09207724
94MP0000462_abnormal_digestive_system1.08875782
95MP0002557_abnormal_social/conspecific_i1.08096030
96MP0002735_abnormal_chemical_nociception1.07593658
97MP0002751_abnormal_autonomic_nervous1.06894641
98MP0005551_abnormal_eye_electrophysiolog1.05459479
99MP0002084_abnormal_developmental_patter1.03592198
100MP0003121_genomic_imprinting1.00995904
101MP0001765_abnormal_ion_homeostasis0.99820338
102MP0005253_abnormal_eye_physiology0.99212128
103MP0002295_abnormal_pulmonary_circulatio0.98426818
104MP0005310_abnormal_salivary_gland0.97006833
105MP0008057_abnormal_DNA_replication0.96353450
106MP0004197_abnormal_fetal_growth/weight/0.94741393
107MP0002102_abnormal_ear_morphology0.94060216
108MP0004859_abnormal_synaptic_plasticity0.93840719
109MP0002269_muscular_atrophy0.93811606
110MP0000678_abnormal_parathyroid_gland0.93658096
111MP0004924_abnormal_behavior0.93365090
112MP0005386_behavior/neurological_phenoty0.93365090
113MP0001727_abnormal_embryo_implantation0.93320269
114MP0010234_abnormal_vibrissa_follicle0.93314558
115MP0002090_abnormal_vision0.92983101
116MP0000049_abnormal_middle_ear0.92528515
117MP0004811_abnormal_neuron_physiology0.91989418
118MP0009046_muscle_twitch0.91692281
119MP0001293_anophthalmia0.90696622
120MP0001502_abnormal_circadian_rhythm0.90196935
121MP0006035_abnormal_mitochondrial_morpho0.89885819
122MP0003953_abnormal_hormone_level0.89188158
123MP0005380_embryogenesis_phenotype0.88857576
124MP0001672_abnormal_embryogenesis/_devel0.88857576
125MP0002177_abnormal_outer_ear0.88468092
126MP0002229_neurodegeneration0.87359731
127MP0009250_abnormal_appendicular_skeleto0.86929954
128MP0005174_abnormal_tail_pigmentation0.86706423
129MP0001929_abnormal_gametogenesis0.85782806
130MP0000026_abnormal_inner_ear0.84363267
131MP0009384_cardiac_valve_regurgitation0.83579561
132MP0000569_abnormal_digit_pigmentation0.83284100
133MP0000428_abnormal_craniofacial_morphol0.83173404
134MP0003755_abnormal_palate_morphology0.83076623
135MP0003935_abnormal_craniofacial_develop0.82348829
136MP0003984_embryonic_growth_retardation0.82318420
137MP0005636_abnormal_mineral_homeostasis0.81806100
138MP0002638_abnormal_pupillary_reflex0.81664886
139MP0002088_abnormal_embryonic_growth/wei0.81661650
140MP0002069_abnormal_eating/drinking_beha0.80900011
141MP0000653_abnormal_sex_gland0.80874924
142MP0001177_atelectasis0.80269698
143MP0002114_abnormal_axial_skeleton0.80011604
144MP0003123_paternal_imprinting0.79940634
145MP0003698_abnormal_male_reproductive0.79484013
146MP0002896_abnormal_bone_mineralization0.79004715
147MP0002127_abnormal_cardiovascular_syste0.78507337
148MP0005448_abnormal_energy_balance0.77977441
149MP0003724_increased_susceptibility_to0.77887366
150MP0003861_abnormal_nervous_system0.77155501
151MP0004134_abnormal_chest_morphology0.76926495
152MP0003943_abnormal_hepatobiliary_system0.76467571
153MP0001299_abnormal_eye_distance/0.76366693
154MP0002928_abnormal_bile_duct0.75904555
155MP0005332_abnormal_amino_acid0.75320279
156MP0003941_abnormal_skin_development0.75039535
157MP0001286_abnormal_eye_development0.74474832
158MP0004264_abnormal_extraembryonic_tissu0.72268005
159MP0003879_abnormal_hair_cell0.70863492
160MP0001963_abnormal_hearing_physiology0.69394899
161MP0000955_abnormal_spinal_cord0.69233120
162MP0002138_abnormal_hepatobiliary_system0.68366031
163MP0002877_abnormal_melanocyte_morpholog0.68143794
164MP0005595_abnormal_vascular_smooth0.67380864

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.27867775
2Bile duct proliferation (HP:0001408)4.23526928
3Abnormal biliary tract physiology (HP:0012439)4.23526928
4Hypothermia (HP:0002045)3.92545064
5Chromsome breakage (HP:0040012)3.80037349
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.77731681
7Progressive macrocephaly (HP:0004481)3.76121814
8Bifid tongue (HP:0010297)3.75346082
9Acute encephalopathy (HP:0006846)3.57010905
10Conjugated hyperbilirubinemia (HP:0002908)3.56319604
11Abnormal mitochondria in muscle tissue (HP:0008316)3.55042032
12Pancreatic fibrosis (HP:0100732)3.48445372
13Abnormal pancreas size (HP:0012094)3.45923198
14Molar tooth sign on MRI (HP:0002419)3.45582075
15Abnormality of midbrain morphology (HP:0002418)3.45582075
16Mitochondrial inheritance (HP:0001427)3.37276175
17Duplicated collecting system (HP:0000081)3.34635363
18Agitation (HP:0000713)3.28539209
19Abnormality of the renal collecting system (HP:0004742)3.25150423
20Pancreatic cysts (HP:0001737)3.11118092
21Reticulocytopenia (HP:0001896)3.08032883
22Progressive inability to walk (HP:0002505)2.97743297
23Exercise-induced muscle cramps (HP:0003710)2.90561244
24Focal motor seizures (HP:0011153)2.88067675
25Symptomatic seizures (HP:0011145)2.86137721
26Abnormality of the intrinsic pathway (HP:0010989)2.82015812
27Hyperinsulinemic hypoglycemia (HP:0000825)2.81106755
28Truncal obesity (HP:0001956)2.78204666
29Vacuolated lymphocytes (HP:0001922)2.76022446
30Retinal dysplasia (HP:0007973)2.72787356
31Hypoglycemic seizures (HP:0002173)2.69561142
32Increased CSF lactate (HP:0002490)2.66115954
33Type II lissencephaly (HP:0007260)2.65304586
34Nephronophthisis (HP:0000090)2.61400797
35Hypoplasia of the pons (HP:0012110)2.61350925
36Tubulointerstitial nephritis (HP:0001970)2.61227725
37Renal Fanconi syndrome (HP:0001994)2.60669191
38Aplasia/Hypoplasia of the tongue (HP:0010295)2.60593256
39Visual hallucinations (HP:0002367)2.58415959
40Febrile seizures (HP:0002373)2.57903634
41Volvulus (HP:0002580)2.57902640
42Failure to thrive in infancy (HP:0001531)2.57260160
43Abnormality of the pons (HP:0007361)2.56946270
44Epileptiform EEG discharges (HP:0011182)2.52228145
45Abnormality of calcium-phosphate metabolism (HP:0100530)2.50603423
46Renal cortical cysts (HP:0000803)2.48511014
47EEG with generalized epileptiform discharges (HP:0011198)2.48201879
48Septate vagina (HP:0001153)2.47088731
49Cerebral edema (HP:0002181)2.40606837
50Hydroureter (HP:0000072)2.40489561
51Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.40076804
52Abnormality of renal resorption (HP:0011038)2.39341578
53Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.37334945
54Congenital stationary night blindness (HP:0007642)2.37218447
55Abnormality of aromatic amino acid family metabolism (HP:0004338)2.36011061
56Aplasia/hypoplasia of the uterus (HP:0008684)2.33290427
57Restlessness (HP:0000711)2.33016383
58Atonic seizures (HP:0010819)2.31929383
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.31139749
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.31139749
61Decreased circulating renin level (HP:0003351)2.29659118
62Congenital sensorineural hearing impairment (HP:0008527)2.29297025
63Aplasia/Hypoplasia of the spleen (HP:0010451)2.29191898
64Hypsarrhythmia (HP:0002521)2.25888794
65Hepatocellular necrosis (HP:0001404)2.25294223
66Confusion (HP:0001289)2.23770562
67Cystic liver disease (HP:0006706)2.23338603
68Limb dystonia (HP:0002451)2.22793931
69Asplenia (HP:0001746)2.22208202
70Osteomalacia (HP:0002749)2.21590236
71Prolonged partial thromboplastin time (HP:0003645)2.21433426
72Optic disc pallor (HP:0000543)2.21281606
73Abnormal pupillary function (HP:0007686)2.21263442
74Increased serum pyruvate (HP:0003542)2.20628656
75Abnormality of the renal medulla (HP:0100957)2.20072615
76Thoracolumbar scoliosis (HP:0002944)2.19031790
77Optic nerve coloboma (HP:0000588)2.18693725
78Abnormality of DNA repair (HP:0003254)2.15039969
79Hepatic necrosis (HP:0002605)2.15038486
80Abnormality of the common coagulation pathway (HP:0010990)2.13499903
81Duplication of thumb phalanx (HP:0009942)2.13363389
82Papillary thyroid carcinoma (HP:0002895)2.13180630
83Ketoacidosis (HP:0001993)2.08572840
84Abnormality of urine glucose concentration (HP:0011016)2.08065855
85Glycosuria (HP:0003076)2.08065855
86Progressive external ophthalmoplegia (HP:0000590)2.05108766
87Epiphyseal dysplasia (HP:0002656)2.04110356
88Inability to walk (HP:0002540)2.03319545
89Increased hepatocellular lipid droplets (HP:0006565)2.03307894
90Generalized aminoaciduria (HP:0002909)2.01975164
91Absent radius (HP:0003974)2.01731309
92True hermaphroditism (HP:0010459)2.01707275
93Patchy hypopigmentation of hair (HP:0011365)2.01403455
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01052363
95Abnormal protein N-linked glycosylation (HP:0012347)2.01052363
96Abnormal protein glycosylation (HP:0012346)2.01052363
97Abnormal glycosylation (HP:0012345)2.01052363
98Meckel diverticulum (HP:0002245)2.00956689
99Impaired smooth pursuit (HP:0007772)2.00377379
100Abnormality of secondary sexual hair (HP:0009888)2.00106332
101Abnormality of the axillary hair (HP:0100134)2.00106332
102Split foot (HP:0001839)1.99767248
103Proximal tubulopathy (HP:0000114)1.99051615
104Aplasia/Hypoplasia of the uvula (HP:0010293)1.97631939
105Abnormality of the ileum (HP:0001549)1.96815150
106Hypoglycemic coma (HP:0001325)1.96421009
107Sclerocornea (HP:0000647)1.95422844
108Abnormality of the labia minora (HP:0012880)1.94908713
109Aplasia involving forearm bones (HP:0009822)1.94565285
110Absent forearm bone (HP:0003953)1.94565285
111Reduced antithrombin III activity (HP:0001976)1.92978512
112Thyroid-stimulating hormone excess (HP:0002925)1.92901487
113Postaxial foot polydactyly (HP:0001830)1.92755601
114Abnormality of the lower motor neuron (HP:0002366)1.92010338
115Gonadotropin excess (HP:0000837)1.91414426
116Exercise intolerance (HP:0003546)1.91216803
117Abnormality of the renal cortex (HP:0011035)1.90884772
118Thyroid carcinoma (HP:0002890)1.90326077
1193-Methylglutaconic aciduria (HP:0003535)1.90245253
120Exercise-induced myalgia (HP:0003738)1.90230025
121Absence seizures (HP:0002121)1.89665075
122Morphological abnormality of the pyramidal tract (HP:0002062)1.89011357
123Hypoplasia of the uterus (HP:0000013)1.88424467
124Thickened helices (HP:0000391)1.88367745
125Hypomagnesemia (HP:0002917)1.87683310
126Hyperglycinuria (HP:0003108)1.87359733
127Hypercortisolism (HP:0001578)1.86124377
128Hyperphosphaturia (HP:0003109)1.84958657
129Type I transferrin isoform profile (HP:0003642)1.84594239
130Short tibia (HP:0005736)1.84391256
131Medial flaring of the eyebrow (HP:0010747)1.84336006
132Protruding tongue (HP:0010808)1.84019861
133Alacrima (HP:0000522)1.83691626
134Microvesicular hepatic steatosis (HP:0001414)1.83310913
135Hypophosphatemic rickets (HP:0004912)1.83210198
136Irregular vertebral endplates (HP:0003301)1.82220387
137Supernumerary spleens (HP:0009799)1.81383394
138White forelock (HP:0002211)1.80891487
139Abnormality of chromosome stability (HP:0003220)1.80560557
140Abnormality of glycolysis (HP:0004366)1.79782729
141Hypergonadotropic hypogonadism (HP:0000815)1.77459726
142Dysostosis multiplex (HP:0000943)1.77049389
143Epileptic encephalopathy (HP:0200134)1.76609660
144Esotropia (HP:0000565)1.76377215
145Unilateral renal agenesis (HP:0000122)1.75806296
146Lipid accumulation in hepatocytes (HP:0006561)1.73980514
147Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73740062
148Blue irides (HP:0000635)1.73718984
149Postaxial hand polydactyly (HP:0001162)1.73225235
150Hemiparesis (HP:0001269)1.72987455
151Progressive neurologic deterioration (HP:0002344)1.72785548
152Oculomotor apraxia (HP:0000657)1.70775764
153Hyperphosphatemia (HP:0002905)1.70593627
154Narrow forehead (HP:0000341)1.70373320
155Decreased subcutaneous fat (HP:0001002)1.69833831
156Tachypnea (HP:0002789)1.69832413
157Congenital glaucoma (HP:0001087)1.69235299
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.69094721
159Male pseudohermaphroditism (HP:0000037)1.68937031
160Dysautonomia (HP:0002459)1.68260496
161Abnormal urine phosphate concentration (HP:0012599)1.68016211
162Genital tract atresia (HP:0001827)1.67382365
163Hypoproteinemia (HP:0003075)1.66949352
164Congenital primary aphakia (HP:0007707)1.66823349
165Excessive salivation (HP:0003781)1.66399923
166Drooling (HP:0002307)1.66399923
167Hyperglycemia (HP:0003074)1.66074279
168Generalized hypopigmentation of hair (HP:0011358)1.65507118
169X-linked dominant inheritance (HP:0001423)1.64963377
170Supranuclear gaze palsy (HP:0000605)1.64822705
171Gait imbalance (HP:0002141)1.64693657
172Infantile muscular hypotonia (HP:0008947)1.64628151
173Bradykinesia (HP:0002067)1.64540880
174Anencephaly (HP:0002323)1.64201769
175Abnormality of the phalanges of the 2nd finger (HP:0009541)1.63243888
176Oligohydramnios (HP:0001562)1.62394084
177Preaxial hand polydactyly (HP:0001177)1.61669942
178Furrowed tongue (HP:0000221)1.61245382
179Vaginal atresia (HP:0000148)1.61173166
180Ragged-red muscle fibers (HP:0003200)1.59367798
181Delayed gross motor development (HP:0002194)1.59092982
182Ectopic kidney (HP:0000086)1.59046448
183Septo-optic dysplasia (HP:0100842)1.58238197
184Horseshoe kidney (HP:0000085)1.58084042
185Abnormality of the preputium (HP:0100587)1.57750903
186Broad foot (HP:0001769)1.57141669
187Clubbing of toes (HP:0100760)1.55808146
188Impaired vibration sensation in the lower limbs (HP:0002166)1.55506536
189Chorioretinal coloboma (HP:0000567)1.55323344
190Abnormality of pyrimidine metabolism (HP:0004353)1.53276431
191Abnormality of the ischium (HP:0003174)1.52743650
192Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.52361077
193Hyperalaninemia (HP:0003348)1.52361077

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.14839196
2LATS13.83387521
3NEK13.35067736
4RIPK43.00877704
5TNIK2.99223271
6CASK2.87536068
7NTRK32.69363539
8DYRK32.60592770
9BMPR22.42866517
10MAP4K22.41591616
11AKT32.41014719
12STK162.39068900
13TAOK32.29151266
14MAPK152.26074808
15SCYL22.21636390
16NME12.21226807
17EIF2AK32.09093342
18BRD42.03949472
19SRPK12.01941747
20RPS6KA41.98941274
21TRIM281.93992660
22IRAK31.90835948
23BCKDK1.89519468
24MAP2K71.86217209
25BMPR1B1.85470017
26NME21.83406625
27ARAF1.74748200
28NEK21.69884635
29PNCK1.63002724
30GRK71.58913069
31MST41.54892250
32BRAF1.54132951
33FRK1.48643672
34EPHA41.48122088
35FGFR31.47338032
36MAP3K21.44482914
37MAPK131.44231294
38IRAK41.36964945
39MAP3K141.31881274
40LMTK21.30793178
41MAP3K121.30567222
42PLK41.27435112
43WNK41.26147960
44IRAK21.26038356
45MKNK11.25677964
46PIK3CG1.25281857
47ERBB31.24997391
48NTRK11.24116094
49NTRK21.20719579
50TTK1.16062282
51PRKCE1.13170784
52MYLK1.11753999
53WNK31.10399050
54MARK11.08818175
55CDC71.07574263
56OBSCN1.06331217
57CAMK2B1.04905806
58PLK21.04588908
59RPS6KB21.01044322
60DYRK1A1.00816735
61BUB10.99525868
62STK38L0.98027947
63DYRK20.97370953
64STK390.94168790
65PLK10.93515352
66CSNK1A1L0.92978606
67CSNK1G20.92925381
68GRK50.92647658
69CCNB10.91853923
70STK30.91711777
71IRAK10.91595275
72MAP3K40.90851680
73CSNK1G30.89426696
74AKT20.89093103
75CAMK2A0.87152695
76CAMK2D0.86305986
77PHKG20.84864282
78PHKG10.84864282
79CAMKK20.84574354
80ERN10.84137494
81FGFR10.83819796
82MAPKAPK50.83032895
83NEK60.82309417
84PRKACB0.81040611
85UHMK10.80728823
86KSR10.80408071
87PLK30.80407836
88ADRBK20.79641714
89SIK20.79190921
90PRKCI0.78792799
91PAK30.77971315
92PASK0.77764257
93MAP3K130.74754350
94MKNK20.74456148
95BCR0.71027623
96HIPK20.70758924
97CSNK1G10.70513870
98FER0.69643126
99MAP2K20.69574359
100MUSK0.68078635
101TSSK60.66390252
102FGR0.63814528
103PRKCG0.60293524
104PINK10.59519469
105CHEK10.59373575
106GRK10.59116587
107CDC42BPA0.58444888
108ATM0.58206787
109CSNK1E0.57924113
110CDK50.57671272
111WEE10.57605266
112EIF2AK20.57443743
113ZAK0.56960576
114FGFR20.56678404
115CAMK2G0.55575166
116CDK190.55340895
117NUAK10.52954725
118PIM20.52448786
119CSNK1D0.51128477
120FES0.50093687
121MAP3K10.49732057
122MAPK100.49657290
123PRKACA0.49492639
124CSNK1A10.49233914
125ADRBK10.49189134
126YES10.49080525
127PKN20.49073737
128RPS6KB10.48670999
129EIF2AK10.48129484
130PRKD20.46732892
131EPHA30.46091939
132CDK20.45789228
133TIE10.45032203
134OXSR10.44502454
135PRKCQ0.42838989
136LIMK10.42761149
137FLT30.42073065
138VRK10.41995099
139PRKG10.40906163
140PAK20.40559768
141RAF10.40554384
142PBK0.40197755
143CDK90.38979119
144IGF1R0.38204223
145ATR0.37633213
146MAP2K10.37132252
147MAP2K40.36991607
148CDK30.36765675
149CDK10.36701428
150CDK180.34706576
151DDR20.33851431
152MET0.33686413
153PRKCA0.33499526
154RPS6KA20.33164413
155MINK10.32368284
156PKN10.31222427
157SYK0.30323622

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030606.49816411
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.61855387
3Oxidative phosphorylation_Homo sapiens_hsa001903.17380977
4Pancreatic secretion_Homo sapiens_hsa049722.72882359
5Propanoate metabolism_Homo sapiens_hsa006402.58638237
6Non-homologous end-joining_Homo sapiens_hsa034502.41818659
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.38498918
8Alzheimers disease_Homo sapiens_hsa050102.35616329
9Sulfur metabolism_Homo sapiens_hsa009202.34649084
10Nicotine addiction_Homo sapiens_hsa050332.33520609
11Vibrio cholerae infection_Homo sapiens_hsa051102.30092463
12Parkinsons disease_Homo sapiens_hsa050122.14486516
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.07714193
14Collecting duct acid secretion_Homo sapiens_hsa049661.90387968
15Insulin secretion_Homo sapiens_hsa049111.86727595
16Selenocompound metabolism_Homo sapiens_hsa004501.82478006
17RNA transport_Homo sapiens_hsa030131.81120853
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80938164
19RNA degradation_Homo sapiens_hsa030181.79029326
20Butanoate metabolism_Homo sapiens_hsa006501.76457759
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.73523456
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.72824056
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72560826
24Basal transcription factors_Homo sapiens_hsa030221.72346262
25mRNA surveillance pathway_Homo sapiens_hsa030151.68740585
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.68516018
27Taste transduction_Homo sapiens_hsa047421.65320447
28Spliceosome_Homo sapiens_hsa030401.64771340
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60150154
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59592445
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59456847
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.59393537
33Pyruvate metabolism_Homo sapiens_hsa006201.58243694
34Cocaine addiction_Homo sapiens_hsa050301.56751633
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.55550553
36Protein digestion and absorption_Homo sapiens_hsa049741.54644070
37Huntingtons disease_Homo sapiens_hsa050161.47156504
38Serotonergic synapse_Homo sapiens_hsa047261.45301656
39Amphetamine addiction_Homo sapiens_hsa050311.44677244
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.42297042
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38143554
42Long-term potentiation_Homo sapiens_hsa047201.34603742
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33026665
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.31531255
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31326150
46N-Glycan biosynthesis_Homo sapiens_hsa005101.26447831
47Other glycan degradation_Homo sapiens_hsa005111.26354767
48Circadian rhythm_Homo sapiens_hsa047101.23318036
49Oocyte meiosis_Homo sapiens_hsa041141.23086634
50Olfactory transduction_Homo sapiens_hsa047401.22010336
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19300944
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18237812
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18064400
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17561657
55Fanconi anemia pathway_Homo sapiens_hsa034601.16298272
56beta-Alanine metabolism_Homo sapiens_hsa004101.15674814
57Regulation of autophagy_Homo sapiens_hsa041401.14411821
58Fatty acid degradation_Homo sapiens_hsa000711.14064776
59Vitamin B6 metabolism_Homo sapiens_hsa007501.13566101
60Glutamatergic synapse_Homo sapiens_hsa047241.13462499
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10396778
62Caffeine metabolism_Homo sapiens_hsa002321.09560268
63GABAergic synapse_Homo sapiens_hsa047271.08639896
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07896923
65Fat digestion and absorption_Homo sapiens_hsa049751.03323954
66Type I diabetes mellitus_Homo sapiens_hsa049401.02184371
67Morphine addiction_Homo sapiens_hsa050321.01014995
68Arginine biosynthesis_Homo sapiens_hsa002201.00499836
69Dopaminergic synapse_Homo sapiens_hsa047280.98944154
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97784491
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97352607
72Nitrogen metabolism_Homo sapiens_hsa009100.97283068
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96076337
74Fatty acid metabolism_Homo sapiens_hsa012120.95908615
75Carbon metabolism_Homo sapiens_hsa012000.95757793
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94327033
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93201335
78Circadian entrainment_Homo sapiens_hsa047130.92572839
79Rheumatoid arthritis_Homo sapiens_hsa053230.92457504
80Prion diseases_Homo sapiens_hsa050200.91558275
81Steroid biosynthesis_Homo sapiens_hsa001000.90920431
82Long-term depression_Homo sapiens_hsa047300.90444769
83Sphingolipid metabolism_Homo sapiens_hsa006000.90071480
84Retinol metabolism_Homo sapiens_hsa008300.90000326
85Folate biosynthesis_Homo sapiens_hsa007900.89559275
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.88753167
87Renin secretion_Homo sapiens_hsa049240.88576773
88Calcium signaling pathway_Homo sapiens_hsa040200.87366377
89Biosynthesis of amino acids_Homo sapiens_hsa012300.84395452
90Cell cycle_Homo sapiens_hsa041100.84271253
91Lysosome_Homo sapiens_hsa041420.83303156
92Cardiac muscle contraction_Homo sapiens_hsa042600.83145465
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81788902
94Salivary secretion_Homo sapiens_hsa049700.81460751
95Chemical carcinogenesis_Homo sapiens_hsa052040.81183874
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79663306
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78834488
98Synaptic vesicle cycle_Homo sapiens_hsa047210.77086142
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.74664882
100Thyroid hormone synthesis_Homo sapiens_hsa049180.74586296
101Tight junction_Homo sapiens_hsa045300.70693809
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69476473
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69091773
104Lysine degradation_Homo sapiens_hsa003100.67713022
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64250252
106Hippo signaling pathway_Homo sapiens_hsa043900.61994122
107Type II diabetes mellitus_Homo sapiens_hsa049300.61100273
108African trypanosomiasis_Homo sapiens_hsa051430.58865186
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58782004
110Base excision repair_Homo sapiens_hsa034100.58604769
111Phagosome_Homo sapiens_hsa041450.58223201
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58189191
113Peroxisome_Homo sapiens_hsa041460.57951360
114Cholinergic synapse_Homo sapiens_hsa047250.57777669
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57507292
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56730356
117ABC transporters_Homo sapiens_hsa020100.56438158
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.56072706
119Vitamin digestion and absorption_Homo sapiens_hsa049770.55193473
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54921804
121Hedgehog signaling pathway_Homo sapiens_hsa043400.54661031
122Melanogenesis_Homo sapiens_hsa049160.54568534
123Ribosome_Homo sapiens_hsa030100.54378516
124TGF-beta signaling pathway_Homo sapiens_hsa043500.54369981
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51858662
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51612796
127Gastric acid secretion_Homo sapiens_hsa049710.49925450
128Renin-angiotensin system_Homo sapiens_hsa046140.49650080
129Glucagon signaling pathway_Homo sapiens_hsa049220.47857999
130Tryptophan metabolism_Homo sapiens_hsa003800.47044459
131Arachidonic acid metabolism_Homo sapiens_hsa005900.46267050
132Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45247607
133Purine metabolism_Homo sapiens_hsa002300.44722094
134Glycerolipid metabolism_Homo sapiens_hsa005610.44428958
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44215129
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43453082
137One carbon pool by folate_Homo sapiens_hsa006700.43162634
138Metabolic pathways_Homo sapiens_hsa011000.42541659
139Arginine and proline metabolism_Homo sapiens_hsa003300.41545471
140cAMP signaling pathway_Homo sapiens_hsa040240.40806738
141Histidine metabolism_Homo sapiens_hsa003400.40321482
142GnRH signaling pathway_Homo sapiens_hsa049120.39500194
143Phototransduction_Homo sapiens_hsa047440.38591966
144Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34693345
145Gap junction_Homo sapiens_hsa045400.33450239
146Oxytocin signaling pathway_Homo sapiens_hsa049210.32351241
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32001584
148Inositol phosphate metabolism_Homo sapiens_hsa005620.31163664
149Estrogen signaling pathway_Homo sapiens_hsa049150.29932158
150Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29451318
151Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28532393
152Tyrosine metabolism_Homo sapiens_hsa003500.28174831
153Ether lipid metabolism_Homo sapiens_hsa005650.27328898
154RNA polymerase_Homo sapiens_hsa030200.26966795
155Proteasome_Homo sapiens_hsa030500.26056763
156Fatty acid elongation_Homo sapiens_hsa000620.25967390
157Axon guidance_Homo sapiens_hsa043600.24130383
158Starch and sucrose metabolism_Homo sapiens_hsa005000.24064950
159Linoleic acid metabolism_Homo sapiens_hsa005910.23486824
160Prolactin signaling pathway_Homo sapiens_hsa049170.21733935
161Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.21147752
162Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20503300
163Phenylalanine metabolism_Homo sapiens_hsa003600.18070637

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