UBA52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)9.78446695
2* cotranslational protein targeting to membrane (GO:0006613)9.69353854
3* protein targeting to ER (GO:0045047)9.64479265
4* translational elongation (GO:0006414)9.61770737
5ribosomal small subunit assembly (GO:0000028)9.37307974
6* establishment of protein localization to endoplasmic reticulum (GO:0072599)9.24570176
7* viral life cycle (GO:0019058)9.12326958
8* cellular protein complex disassembly (GO:0043624)9.10839854
9* protein localization to endoplasmic reticulum (GO:0070972)9.02008808
10* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)8.85429326
11maturation of SSU-rRNA (GO:0030490)8.71285490
12* translational initiation (GO:0006413)8.18154083
13* protein complex disassembly (GO:0043241)7.84639592
14* macromolecular complex disassembly (GO:0032984)7.29359807
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.14196566
16ribosomal large subunit biogenesis (GO:0042273)6.98933427
17ATP synthesis coupled proton transport (GO:0015986)6.83095119
18energy coupled proton transport, down electrochemical gradient (GO:0015985)6.83095119
19* protein targeting to membrane (GO:0006612)6.47797737
20* nuclear-transcribed mRNA catabolic process (GO:0000956)6.05726882
21* translation (GO:0006412)5.85525922
22* mRNA catabolic process (GO:0006402)5.74252673
23* RNA catabolic process (GO:0006401)5.19066221
24ribonucleoprotein complex biogenesis (GO:0022613)4.94867105
25* establishment of protein localization to membrane (GO:0090150)4.44223898
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.33532986
27respiratory electron transport chain (GO:0022904)4.18590479
28negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.18083670
29negative regulation of cell killing (GO:0031342)4.18083670
30electron transport chain (GO:0022900)4.09504872
31* protein targeting (GO:0006605)4.03265641
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.00049871
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.98098928
34positive regulation of gamma-delta T cell activation (GO:0046645)3.97767936
35cellular component biogenesis (GO:0044085)3.94691900
36formation of translation preinitiation complex (GO:0001731)3.90317216
37rRNA processing (GO:0006364)3.88227613
38positive regulation by symbiont of host defense response (GO:0052509)3.86519756
39modulation by symbiont of host defense response (GO:0052031)3.86519756
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.86519756
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.86519756
42positive regulation by organism of defense response of other organism involved in symbiotic interact3.86519756
43modulation by symbiont of host immune response (GO:0052553)3.86519756
44leukocyte aggregation (GO:0070486)3.85100730
45* establishment of protein localization to organelle (GO:0072594)3.84155952
46GTP biosynthetic process (GO:0006183)3.82596256
47antigen processing and presentation of endogenous antigen (GO:0019883)3.80849308
48establishment of protein localization to mitochondrial membrane (GO:0090151)3.74562463
49establishment of integrated proviral latency (GO:0075713)3.73369839
50rRNA metabolic process (GO:0016072)3.71110100
51protein neddylation (GO:0045116)3.70563554
52antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.66597950
53UTP biosynthetic process (GO:0006228)3.60891172
54* protein localization to membrane (GO:0072657)3.41242782
55respiratory burst (GO:0045730)3.34689815
56purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.26237630
57detection of bacterium (GO:0016045)3.25629798
58establishment of viral latency (GO:0019043)3.23099776
59spliceosomal complex assembly (GO:0000245)3.21294529
60termination of RNA polymerase III transcription (GO:0006386)3.18724783
61transcription elongation from RNA polymerase III promoter (GO:0006385)3.18724783
62positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.17837278
63neutrophil activation involved in immune response (GO:0002283)3.17135212
64purine nucleoside triphosphate biosynthetic process (GO:0009145)3.15254691
65proteasome assembly (GO:0043248)3.14834169
66detection of other organism (GO:0098543)3.13200604
67spliceosomal snRNP assembly (GO:0000387)3.11797697
68ATP biosynthetic process (GO:0006754)3.10135165
69UTP metabolic process (GO:0046051)3.07597240
70keratinocyte development (GO:0003334)3.05649534
71regulation of B cell receptor signaling pathway (GO:0050855)2.99100059
72negative regulation of erythrocyte differentiation (GO:0045647)2.98648164
73ribonucleoside triphosphate biosynthetic process (GO:0009201)2.96586948
74negative regulation of phagocytosis (GO:0050765)2.95711419
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.92703122
76response to peptidoglycan (GO:0032494)2.92635179
777-methylguanosine mRNA capping (GO:0006370)2.91847257
78exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90916201
79DNA deamination (GO:0045006)2.89934460
80* cellular component disassembly (GO:0022411)2.89825866
81positive thymic T cell selection (GO:0045059)2.89696066
82modulation by virus of host process (GO:0019054)2.88404852
837-methylguanosine RNA capping (GO:0009452)2.87137491
84RNA capping (GO:0036260)2.87137491
85chaperone-mediated protein transport (GO:0072321)2.80569253
86* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.78311119
87DNA damage response, detection of DNA damage (GO:0042769)2.78227416
88* protein localization to organelle (GO:0033365)2.76349339
89guanosine-containing compound biosynthetic process (GO:1901070)2.73796264
90CTP metabolic process (GO:0046036)2.73626880
91CTP biosynthetic process (GO:0006241)2.73626880
92transcription elongation from RNA polymerase I promoter (GO:0006362)2.68194477
93DNA strand elongation involved in DNA replication (GO:0006271)2.67904347
94negative regulation of interleukin-12 production (GO:0032695)2.67295368
95positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.66977897
96regulation of cellular amino acid metabolic process (GO:0006521)2.66782469
97immunoglobulin mediated immune response (GO:0016064)2.66403288
98pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.64974443
99deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.64836111
100* negative regulation of ligase activity (GO:0051352)2.63635032
101* negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.63635032
102* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.61599018
103regulation of T cell tolerance induction (GO:0002664)2.61534829
104mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.61203384
105mitochondrial respiratory chain complex I assembly (GO:0032981)2.61203384
106NADH dehydrogenase complex assembly (GO:0010257)2.61203384
107thymic T cell selection (GO:0045061)2.60997536
108positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.60911688
109pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.59394544
110termination of RNA polymerase I transcription (GO:0006363)2.59180408
111regulation of gamma-delta T cell activation (GO:0046643)2.58650860
112oxidative phosphorylation (GO:0006119)2.57484311
113tolerance induction (GO:0002507)2.55708469
114* gene expression (GO:0010467)2.54922568
115* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.54039967
116* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.54039967
117regulation of superoxide anion generation (GO:0032928)2.53900627
118negative thymic T cell selection (GO:0045060)2.52143255
119negative T cell selection (GO:0043383)2.51737964
120pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.51596418
121telomere maintenance via semi-conservative replication (GO:0032201)2.51584866
122* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.50797173
123transcription-coupled nucleotide-excision repair (GO:0006283)2.50025400
124DNA strand elongation (GO:0022616)2.49252108
125* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.48703466
126* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.48703466
127* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.48703466
128protein complex biogenesis (GO:0070271)2.48594103
129* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.48365503
130GDP-mannose metabolic process (GO:0019673)2.48284563
131negative regulation of RNA splicing (GO:0033119)2.47556189
132modulation by symbiont of host cellular process (GO:0044068)2.47427016
133* signal transduction involved in DNA integrity checkpoint (GO:0072401)2.47160436
134* signal transduction involved in DNA damage checkpoint (GO:0072422)2.47160436
135* signal transduction involved in cell cycle checkpoint (GO:0072395)2.45173983
136positive regulation of B cell differentiation (GO:0045579)2.44869416
137ncRNA 3-end processing (GO:0043628)2.43690530
138regulation of gamma-delta T cell differentiation (GO:0045586)2.42894461
139T cell migration (GO:0072678)2.39802687
140macrophage activation involved in immune response (GO:0002281)2.39050618
141response to interferon-beta (GO:0035456)2.38799887
142cellular extravasation (GO:0045123)2.38353412
143T cell selection (GO:0045058)2.38286712
144negative regulation of innate immune response (GO:0045824)2.37409293
145detection of external biotic stimulus (GO:0098581)2.34624428
146negative regulation of lymphocyte mediated immunity (GO:0002707)2.33963337
147antigen processing and presentation via MHC class Ib (GO:0002475)2.33608812
148NIK/NF-kappaB signaling (GO:0038061)2.33245846
149response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.33119583
150response to host immune response (GO:0052572)2.33119583
151B cell receptor signaling pathway (GO:0050853)2.31584166
152regulation of tolerance induction (GO:0002643)2.29755262
153leukocyte degranulation (GO:0043299)2.28505299
154negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.28405525
155positive T cell selection (GO:0043368)2.28320733
156regulation of B cell differentiation (GO:0045577)2.27028206
157regulation of mast cell degranulation (GO:0043304)2.26932747
158* viral transcription (GO:0019083)12.2342320
159* translational termination (GO:0006415)11.6438130
160ribosomal small subunit biogenesis (GO:0042274)11.5333243

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.87435526
2MYC_18555785_ChIP-Seq_MESCs_Mouse5.00895133
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.10962577
4* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.91696919
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.89245475
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.84519559
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.63533215
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.60980676
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.50950815
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.44871919
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.40455197
12E2F7_22180533_ChIP-Seq_HELA_Human3.32286959
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.21903814
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.21480473
15XRN2_22483619_ChIP-Seq_HELA_Human3.02297647
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.96737104
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90928874
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.87340823
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78116577
20TTF2_22483619_ChIP-Seq_HELA_Human2.66501054
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.60783645
22MYC_22102868_ChIP-Seq_BL_Human2.58550625
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55059412
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.53499397
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43103565
26ELK1_19687146_ChIP-ChIP_HELA_Human2.31753515
27* VDR_23849224_ChIP-Seq_CD4+_Human2.30141375
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.28608219
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.25360868
30DCP1A_22483619_ChIP-Seq_HELA_Human2.18112408
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.17665331
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10700765
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08545934
34ELK1_22589737_ChIP-Seq_MCF10A_Human2.06015097
35* KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.02260092
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.00824581
37E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00087966
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.92089182
39FOXP3_21729870_ChIP-Seq_TREG_Human1.89250242
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.88885484
41VDR_24763502_ChIP-Seq_THP-1_Human1.83924024
42MAF_26560356_Chip-Seq_TH1_Human1.80342215
43LXR_22292898_ChIP-Seq_THP-1_Human1.75694309
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73087460
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70567704
46SPI1_23547873_ChIP-Seq_NB4_Human1.70383146
47* MAF_26560356_Chip-Seq_TH2_Human1.70260472
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.69938452
49UTX_26944678_Chip-Seq_JUKART_Human1.69923030
50* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63986503
51MYC_18940864_ChIP-ChIP_HL60_Human1.63919221
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.62474924
53IRF8_22096565_ChIP-ChIP_GC-B_Human1.61961008
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.60531326
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60498536
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60358270
57* YY1_21170310_ChIP-Seq_MESCs_Mouse1.59244406
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55999273
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53097266
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50112608
61STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49631063
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49498066
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.45147978
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44062531
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41432031
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41201329
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40407942
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39163704
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.37860028
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.36681578
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36056555
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33547898
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31290908
74KDM2B_26808549_Chip-Seq_DND41_Human1.31261314
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30935191
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.29673744
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28970734
78TCF7_22412390_ChIP-Seq_EML_Mouse1.27584267
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.27097747
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26745869
81OCT4_18692474_ChIP-Seq_MEFs_Mouse1.26602146
82PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25988209
83BCL6_27268052_Chip-Seq_Bcells_Human1.25896600
84P68_20966046_ChIP-Seq_HELA_Human1.25659826
85IRF1_19129219_ChIP-ChIP_H3396_Human1.25345025
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.23605558
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.22775965
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21416583
89RACK7_27058665_Chip-Seq_MCF-7_Human1.20398966
90CTCF_26484167_Chip-Seq_Bcells_Mouse1.18938508
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18727115
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18709280
93BCOR_27268052_Chip-Seq_Bcells_Human1.18615589
94* GABP_19822575_ChIP-Seq_HepG2_Human1.17420910
95IRF8_21731497_ChIP-ChIP_J774_Mouse1.16720899
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16421033
97POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15497073
98MYB_26560356_Chip-Seq_TH1_Human1.14156198
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12952784
100* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12390541
101ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12269173
102KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12112916
103SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10987724
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10904804
105MYB_26560356_Chip-Seq_TH2_Human1.10339114
106TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09935584
107NCOR1_26117541_ChIP-Seq_K562_Human1.08918332
108PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08368403
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07336344
110CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06436979
111SOX2_18692474_ChIP-Seq_MEFs_Mouse1.06306718
112CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06196913
113FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05906521
114SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05820868
115EGR1_19374776_ChIP-ChIP_THP-1_Human1.05590733
116NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05361439
117FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04968100
118TP63_19390658_ChIP-ChIP_HaCaT_Human1.04443480
119KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01900410
120KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01900410
121KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01900410
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01124658
123SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01047672
124MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00498762
125ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99011323
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96098883
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95825485
128BP1_19119308_ChIP-ChIP_Hs578T_Human0.95756345
129VDR_21846776_ChIP-Seq_THP-1_Human0.94839109
130SOX2_16153702_ChIP-ChIP_HESCs_Human0.93408408
131* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91003816
132MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.90848340
133NANOG_18692474_ChIP-Seq_MEFs_Mouse0.90396417
134YY1_22570637_ChIP-Seq_MALME-3M_Human0.90332736
135* CIITA_25753668_ChIP-Seq_RAJI_Human0.85398427
136SOX17_20123909_ChIP-Seq_XEN_Mouse0.85206536
137ZNF263_19887448_ChIP-Seq_K562_Human0.84901090
138POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83310989
139* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83028994
140DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81167668
141BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80970304
142HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80425056
143NOTCH1_21737748_ChIP-Seq_TLL_Human0.79317435
144TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77430132
145* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.76908185
146CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.75969794
147NANOG_16153702_ChIP-ChIP_HESCs_Human0.72357363
148BMI1_23680149_ChIP-Seq_NPCS_Mouse0.71272645

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation8.42055915
2MP0004381_abnormal_hair_follicle3.95149689
3MP0003136_yellow_coat_color3.75275009
4MP0003436_decreased_susceptibility_to3.60712835
5MP0002796_impaired_skin_barrier2.90099638
6MP0005671_abnormal_response_to2.89329978
7MP0003693_abnormal_embryo_hatching2.88852959
8MP0001835_abnormal_antigen_presentation2.75208754
9MP0003303_peritoneal_inflammation2.70984199
10MP0000685_abnormal_immune_system2.69612569
11MP0004957_abnormal_blastocyst_morpholog2.67457049
12MP0005387_immune_system_phenotype2.47175379
13MP0001790_abnormal_immune_system2.47175379
14MP0002419_abnormal_innate_immunity2.34009562
15MP0002420_abnormal_adaptive_immunity2.29723719
16MP0001819_abnormal_immune_cell2.27159191
17MP0002723_abnormal_immune_serum2.24803723
18MP0003806_abnormal_nucleotide_metabolis2.19015210
19MP0009785_altered_susceptibility_to2.17151318
20MP0002452_abnormal_antigen_presenting2.13902894
21MP0003315_abnormal_perineum_morphology2.11876617
22MP0003941_abnormal_skin_development2.09631865
23MP0005501_abnormal_skin_physiology2.08816158
24MP0006082_CNS_inflammation2.02141147
25MP0002938_white_spotting1.97028268
26MP0001873_stomach_inflammation1.89526846
27MP0005409_darkened_coat_color1.89442624
28MP0000716_abnormal_immune_system1.86728093
29MP0003077_abnormal_cell_cycle1.85118932
30MP0008057_abnormal_DNA_replication1.77892953
31MP0008260_abnormal_autophagy1.74467682
32MP0008932_abnormal_embryonic_tissue1.72434866
33MP0003786_premature_aging1.71871488
34MP0000372_irregular_coat_pigmentation1.70470548
35MP0002429_abnormal_blood_cell1.66720098
36MP0002102_abnormal_ear_morphology1.62175060
37MP0000689_abnormal_spleen_morphology1.59955298
38MP0005058_abnormal_lysosome_morphology1.59744017
39MP0010155_abnormal_intestine_physiology1.59708453
40MP0002396_abnormal_hematopoietic_system1.59256506
41MP0003718_maternal_effect1.56063466
42MP0005464_abnormal_platelet_physiology1.55567498
43MP0009278_abnormal_bone_marrow1.51731334
44MP0010094_abnormal_chromosome_stability1.51048954
45MP0001529_abnormal_vocalization1.51030493
46MP0003300_gastrointestinal_ulcer1.50357422
47MP0001845_abnormal_inflammatory_respons1.50353168
48MP0003866_abnormal_defecation1.48338853
49MP0009333_abnormal_splenocyte_physiolog1.48022046
50MP0001727_abnormal_embryo_implantation1.47425043
51MP0004947_skin_inflammation1.47390161
52MP0003763_abnormal_thymus_physiology1.46708516
53MP0005408_hypopigmentation1.46450140
54MP0001533_abnormal_skeleton_physiology1.45804956
55MP0002009_preneoplasia1.41898508
56MP0006292_abnormal_olfactory_placode1.41662769
57MP0002277_abnormal_respiratory_mucosa1.41432920
58MP0002098_abnormal_vibrissa_morphology1.41103957
59MP0002163_abnormal_gland_morphology1.40559133
60MP0008789_abnormal_olfactory_epithelium1.40250252
61MP0002132_abnormal_respiratory_system1.39928356
62MP0003191_abnormal_cellular_cholesterol1.39498318
63MP0008995_early_reproductive_senescence1.39131676
64MP0003938_abnormal_ear_development1.36768464
65MP0001346_abnormal_lacrimal_gland1.36451951
66MP0003111_abnormal_nucleus_morphology1.35927738
67MP0002282_abnormal_trachea_morphology1.33334295
68MP0000537_abnormal_urethra_morphology1.32793768
69MP0000762_abnormal_tongue_morphology1.30964152
70MP0001905_abnormal_dopamine_level1.30563454
71MP0003567_abnormal_fetal_cardiomyocyte1.29065133
72MP0008469_abnormal_protein_level1.28403755
73MP0005451_abnormal_body_composition1.24720284
74MP0005174_abnormal_tail_pigmentation1.22272436
75MP0000383_abnormal_hair_follicle1.21745665
76MP0000566_synostosis1.21181993
77MP0001216_abnormal_epidermal_layer1.19872469
78MP0001663_abnormal_digestive_system1.19805454
79MP0000750_abnormal_muscle_regeneration1.18664231
80MP0002751_abnormal_autonomic_nervous1.15275012
81MP0004185_abnormal_adipocyte_glucose1.14787406
82MP0002638_abnormal_pupillary_reflex1.14719768
83MP0010030_abnormal_orbit_morphology1.14594358
84MP0000647_abnormal_sebaceous_gland1.12136926
85MP0010771_integument_phenotype1.12111852
86MP0005075_abnormal_melanosome_morpholog1.10706753
87MP0006035_abnormal_mitochondrial_morpho1.09376168
88MP0001853_heart_inflammation1.08759505
89MP0002060_abnormal_skin_morphology1.00865380
90MP0000313_abnormal_cell_death1.00786313
91MP0002249_abnormal_larynx_morphology1.00378201
92MP0004858_abnormal_nervous_system0.99694480
93MP0002148_abnormal_hypersensitivity_rea0.94296744
94MP0005397_hematopoietic_system_phenotyp0.94108374
95MP0001545_abnormal_hematopoietic_system0.94108374
96MP0004808_abnormal_hematopoietic_stem0.93105626
97MP0004510_myositis0.93031836
98MP0000490_abnormal_crypts_of0.92693747
99MP0000465_gastrointestinal_hemorrhage0.91623185
100MP0001879_abnormal_lymphatic_vessel0.91116621
101MP0006036_abnormal_mitochondrial_physio0.90696420
102MP0004133_heterotaxia0.90045891
103MP0000049_abnormal_middle_ear0.89907059
104MP0000343_altered_response_to0.89769072
105MP0008007_abnormal_cellular_replicative0.89363093
106MP0002095_abnormal_skin_pigmentation0.88822233
107MP0000467_abnormal_esophagus_morphology0.87532836
108MP0006072_abnormal_retinal_apoptosis0.86004430
109MP0005381_digestive/alimentary_phenotyp0.83718020
110MP0008058_abnormal_DNA_repair0.82226135
111MP0001919_abnormal_reproductive_system0.81116039
112MP0005084_abnormal_gallbladder_morpholo0.79986434
113MP0000858_altered_metastatic_potential0.79590827
114MP0009840_abnormal_foam_cell0.78890495
115MP0001851_eye_inflammation0.78572324
116MP0003828_pulmonary_edema0.77842139
117MP0002998_abnormal_bone_remodeling0.77734817
118MP0000678_abnormal_parathyroid_gland0.77707939
119MP0009931_abnormal_skin_appearance0.77414625
120MP0000377_abnormal_hair_follicle0.76656627
121MP0009764_decreased_sensitivity_to0.76511020
122MP0003724_increased_susceptibility_to0.74239790
123MP0000703_abnormal_thymus_morphology0.73776535
124MP0005390_skeleton_phenotype0.73294137
125MP0001286_abnormal_eye_development0.73141193
126MP0002933_joint_inflammation0.72629398
127MP0002166_altered_tumor_susceptibility0.72510976
128MP0005083_abnormal_biliary_tract0.72312049
129MP0003172_abnormal_lysosome_physiology0.72219136
130MP0003011_delayed_dark_adaptation0.72140782
131MP0001340_abnormal_eyelid_morphology0.71980873
132MP0003453_abnormal_keratinocyte_physiol0.71767993
133MP0003186_abnormal_redox_activity0.71402794
134MP0005310_abnormal_salivary_gland0.70451895
135MP0005394_taste/olfaction_phenotype0.70401350
136MP0005499_abnormal_olfactory_system0.70401350
137MP0002722_abnormal_immune_system0.70361510
138MP0003638_abnormal_response/metabolism_0.69263686
139MP0010678_abnormal_skin_adnexa0.68272610
140MP0001800_abnormal_humoral_immune0.66832550
141MP0002006_tumorigenesis0.66358923
142MP0001730_embryonic_growth_arrest0.65671647
143MP0004883_abnormal_blood_vessel0.65371687
144MP0000350_abnormal_cell_proliferation0.64817740
145MP0003705_abnormal_hypodermis_morpholog0.63546633
146MP0002653_abnormal_ependyma_morphology0.63049420
147MP0003937_abnormal_limbs/digits/tail_de0.62645487
148MP0000470_abnormal_stomach_morphology0.60553039
149MP0005379_endocrine/exocrine_gland_phen0.60419969
150MP0005025_abnormal_response_to0.60412878
151MP0003075_altered_response_to0.59970219
152MP0002405_respiratory_system_inflammati0.59616620
153MP0002398_abnormal_bone_marrow0.59503460
154MP0002127_abnormal_cardiovascular_syste0.59088451
155MP0009763_increased_sensitivity_to0.58500740
156MP0005377_hearing/vestibular/ear_phenot0.58432444
157MP0005000_abnormal_immune_tolerance0.58270215
158MP0002019_abnormal_tumor_incidence0.57855259
159MP0002111_abnormal_tail_morphology0.57012605

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)9.75250236
2Reticulocytopenia (HP:0001896)8.76868503
3Abnormal number of erythroid precursors (HP:0012131)8.37742259
4Macrocytic anemia (HP:0001972)6.89839816
5Pallor (HP:0000980)6.17234040
6Eczematoid dermatitis (HP:0000976)4.94238067
7Acute necrotizing encephalopathy (HP:0006965)4.82781117
8Increased hepatocellular lipid droplets (HP:0006565)4.65319718
9Recurrent abscess formation (HP:0002722)4.41820093
10Mitochondrial inheritance (HP:0001427)4.32419497
11Recurrent bacterial skin infections (HP:0005406)4.29379450
12Abnormality of macrophages (HP:0004311)4.24640624
13Abnormal mitochondria in muscle tissue (HP:0008316)4.04836662
14Parakeratosis (HP:0001036)4.04695361
15Lipid accumulation in hepatocytes (HP:0006561)4.00120788
16Progressive macrocephaly (HP:0004481)3.99060615
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.91334861
18Obstructive lung disease (HP:0006536)3.89343650
19Chronic obstructive pulmonary disease (HP:0006510)3.89343650
20Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.88400857
21Congenital, generalized hypertrichosis (HP:0004540)3.86757375
22Renal Fanconi syndrome (HP:0001994)3.86417625
23Acute encephalopathy (HP:0006846)3.65371132
24Abnormal hemoglobin (HP:0011902)3.63555613
25Myositis (HP:0100614)3.49176488
26Hypochromic microcytic anemia (HP:0004840)3.48928458
27Increased CSF lactate (HP:0002490)3.46781519
28Abnormality of the axillary hair (HP:0100134)3.46348143
29Abnormality of secondary sexual hair (HP:0009888)3.46348143
30Exertional dyspnea (HP:0002875)3.42358777
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.41956500
32Hepatocellular necrosis (HP:0001404)3.34794688
33Respiratory difficulties (HP:0002880)3.31701383
34Hypochromic anemia (HP:0001931)3.22609459
35Stenosis of the external auditory canal (HP:0000402)3.18609845
36Mediastinal lymphadenopathy (HP:0100721)3.17980479
37Stomatitis (HP:0010280)3.17246898
38Congenital ichthyosiform erythroderma (HP:0007431)3.16593470
39Abnormal delayed hypersensitivity skin test (HP:0002963)3.14959210
40Aplasia/Hypoplasia of the sacrum (HP:0008517)3.12190947
41Meningitis (HP:0001287)3.11403678
42Increased IgE level (HP:0003212)3.07273446
43Recurrent gram-negative bacterial infections (HP:0005420)3.05650179
443-Methylglutaconic aciduria (HP:0003535)3.04804751
45Increased intramyocellular lipid droplets (HP:0012240)3.04157302
46IgM deficiency (HP:0002850)2.98785085
47Depressed nasal ridge (HP:0000457)2.96816086
48Recurrent fungal infections (HP:0002841)2.91496136
49Urticaria (HP:0001025)2.86068910
50Cellulitis (HP:0100658)2.81794983
51Hepatic necrosis (HP:0002605)2.74586493
52Abnormality of reticulocytes (HP:0004312)2.74001066
53Woolly hair (HP:0002224)2.70665393
54Orchitis (HP:0100796)2.69770307
55Gastrointestinal infarctions (HP:0005244)2.69614482
56Recurrent skin infections (HP:0001581)2.69580772
57Encephalitis (HP:0002383)2.64180897
58Gastrointestinal inflammation (HP:0004386)2.63630900
59Migraine (HP:0002076)2.59612261
60Absent thumb (HP:0009777)2.59403409
61Panhypogammaglobulinemia (HP:0003139)2.55796651
62Inflammation of the large intestine (HP:0002037)2.55750182
63Increased IgM level (HP:0003496)2.55195318
64Exercise intolerance (HP:0003546)2.53507303
65Microcytic anemia (HP:0001935)2.53048532
66Abnormality of T cell physiology (HP:0011840)2.52424834
67Elevated erythrocyte sedimentation rate (HP:0003565)2.51202260
68Colitis (HP:0002583)2.50055036
69Recurrent viral infections (HP:0004429)2.49918136
70Optic disc pallor (HP:0000543)2.48480503
7111 pairs of ribs (HP:0000878)2.47766586
72Decreased activity of mitochondrial respiratory chain (HP:0008972)2.47184928
73Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.47184928
74Cerebral edema (HP:0002181)2.44486282
75Lymphopenia (HP:0001888)2.44356029
76Increased muscle lipid content (HP:0009058)2.42571738
77Mesangial abnormality (HP:0001966)2.42014341
78Concave nail (HP:0001598)2.41525629
79Abnormality of the heme biosynthetic pathway (HP:0010472)2.40338216
80Abnormality of T cells (HP:0002843)2.39466270
81Spontaneous hematomas (HP:0007420)2.37638483
82Pustule (HP:0200039)2.37584408
83Recurrent cutaneous fungal infections (HP:0011370)2.36943518
84Chronic mucocutaneous candidiasis (HP:0002728)2.36943518
85Abnormality of cells of the lymphoid lineage (HP:0012140)2.34559423
86Partial duplication of thumb phalanx (HP:0009944)2.34099894
87Vasculitis (HP:0002633)2.33923512
88Multiple enchondromatosis (HP:0005701)2.33258627
89Petechiae (HP:0000967)2.31082616
90Increased serum ferritin (HP:0003281)2.30997343
91Respiratory failure (HP:0002878)2.28140895
92Gastrointestinal stroma tumor (HP:0100723)2.26984153
93Nasal polyposis (HP:0100582)2.26017204
94Thick lower lip vermilion (HP:0000179)2.24577966
95Retrobulbar optic neuritis (HP:0100654)2.24463334
96Optic neuritis (HP:0100653)2.24463334
97Hepatosplenomegaly (HP:0001433)2.23814332
98Agammaglobulinemia (HP:0004432)2.22905696
99Leukodystrophy (HP:0002415)2.22468248
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.20805133
101Triphalangeal thumb (HP:0001199)2.18422910
102Fragile nails (HP:0001808)2.16909364
103Hypotrichosis (HP:0001006)2.16900646
104Abnormality of renal resorption (HP:0011038)2.15926530
105Gingivitis (HP:0000230)2.13982004
106Septate vagina (HP:0001153)2.11296254
107Asplenia (HP:0001746)2.10031011
108Colon cancer (HP:0003003)2.09252015
109Abnormality of the nasal mucosa (HP:0000433)2.06303264
110Increased serum lactate (HP:0002151)2.05234026
111Breast hypoplasia (HP:0003187)2.02620348
112Partial duplication of the phalanx of hand (HP:0009999)2.02108582
113Verrucae (HP:0200043)2.01952266
114Papilloma (HP:0012740)2.01952266
115Aplastic anemia (HP:0001915)2.01124399
116Aplasia/Hypoplasia of the thymus (HP:0010515)2.00455807
117Granulocytopenia (HP:0001913)1.98541139
118Hypoplasia of the radius (HP:0002984)1.96877591
119Amniotic constriction ring (HP:0009775)1.96719052
120Abnormality of placental membranes (HP:0011409)1.96719052
121Abnormality of glycolysis (HP:0004366)1.96542472
122Increased serum pyruvate (HP:0003542)1.96542472
123Seborrheic dermatitis (HP:0001051)1.95619619
124Trismus (HP:0000211)1.93869600
125Hypergammaglobulinemia (HP:0010702)1.92393147
126Anorexia (HP:0002039)1.92347266
127Neonatal respiratory distress (HP:0002643)1.91276343
128Oral leukoplakia (HP:0002745)1.90154703
129Lactic acidosis (HP:0003128)1.87262371
130Duplication of thumb phalanx (HP:0009942)1.87096924
131Polycythemia (HP:0001901)1.87067540
132Aplasia/Hypoplasia of the spleen (HP:0010451)1.85084129
133Purpura (HP:0000979)1.83492989
134Absent radius (HP:0003974)1.83212739
135Aplasia cutis congenita (HP:0001057)1.81395422
136Progressive muscle weakness (HP:0003323)1.81313630
137Rough bone trabeculation (HP:0100670)1.80947623
138Abnormality of iron homeostasis (HP:0011031)1.80580875
139Glossoptosis (HP:0000162)1.79930088
140Hyperphosphaturia (HP:0003109)1.79878122
141Duplicated collecting system (HP:0000081)1.79629038
142Sparse eyelashes (HP:0000653)1.78599562
143Hypoproteinemia (HP:0003075)1.75603299
144Abnormality of the parietal bone (HP:0002696)1.73094922
145Abnormal number of incisors (HP:0011064)1.72452008
146Segmental peripheral demyelination/remyelination (HP:0003481)1.71515652
147Prolonged bleeding time (HP:0003010)1.71056193
148T lymphocytopenia (HP:0005403)1.69932007
149Absent forearm bone (HP:0003953)1.69912200
150Aplasia involving forearm bones (HP:0009822)1.69912200
151Hypertensive crisis (HP:0100735)1.69901103
152Horseshoe kidney (HP:0000085)1.69491193
153Glycosuria (HP:0003076)1.69280740
154Abnormality of urine glucose concentration (HP:0011016)1.69280740
155Renal tubular dysfunction (HP:0000124)1.64529480
156Secondary amenorrhea (HP:0000869)1.62130506
157Hypoparathyroidism (HP:0000829)1.59656637
158Carpal bone hypoplasia (HP:0001498)1.59285638
159Cleft eyelid (HP:0000625)1.59208027
160Thrombocytosis (HP:0001894)1.57244897
161Aplasia/Hypoplasia of the ulna (HP:0006495)1.56899816
162Hypoplastic pelvis (HP:0008839)1.56266800
163Cerebral hypomyelination (HP:0006808)1.53502859
164Abnormal urine phosphate concentration (HP:0012599)1.52231326
165Sensory axonal neuropathy (HP:0003390)1.51404234
166Patellar aplasia (HP:0006443)1.51340120
167Erythroderma (HP:0001019)1.50923261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME26.50780094
2TLK13.68570615
3BUB13.41110755
4RIPK43.35220748
5MST43.03259617
6WEE12.70077612
7VRK22.67930559
8PRPF4B2.66999052
9ERN12.61628538
10SMG12.59586886
11STK162.58151912
12LRRK22.52816700
13VRK12.46594193
14MAP2K32.42933466
15SRPK12.39614541
16IRAK42.37092746
17NME12.27112556
18RPS6KB22.24933336
19TRIB32.24924694
20PIM22.12863273
21DYRK32.10863071
22KDR1.97852440
23TGFBR11.83978370
24TAOK21.61181214
25CSK1.54249491
26ZAP701.52463438
27ILK1.50024985
28TAOK11.40050534
29DYRK21.33837355
30IRAK31.31089142
31EIF2AK31.24228809
32MYLK1.23543546
33AURKB1.22749411
34SIK11.18940734
35RPS6KA51.18695443
36TBK11.18448991
37RPS6KA41.18424885
38MKNK11.17999561
39MAP4K11.17232059
40PASK1.12811764
41PBK1.12113426
42BMPR1B1.08881069
43TNK21.07833277
44UHMK11.07370992
45MAP2K21.07087623
46MARK31.04513635
47HCK1.04171245
48MAP3K131.03713210
49MAPKAPK31.02687637
50LIMK11.01486439
51ARAF1.01148865
52ICK0.99367691
53PNCK0.99210549
54PTK60.99123138
55EEF2K0.97998547
56JAK30.97627952
57AURKA0.96314946
58GRK70.92725096
59NUAK10.92644965
60CDK40.92633996
61GRK60.91816198
62TXK0.91232970
63CSNK2A20.91017778
64CDK70.90793824
65CDK190.88695990
66EPHB20.88411766
67IKBKE0.87227175
68MAP3K30.86774025
69FGR0.86701457
70STK390.84318727
71MAP3K10.83923927
72STK100.83651054
73BRAF0.81735857
74BRSK20.80484031
75TESK20.79431970
76DAPK30.78261822
77KSR20.77773295
78MST1R0.77469996
79EPHA20.77041897
80MAP3K100.76560042
81MAPKAPK50.76246576
82CSNK2A10.73705102
83MAP3K110.72654811
84EPHB10.72622731
85PLK40.72224526
86ABL20.69293553
87CDC70.67102516
88EIF2AK20.63903509
89PLK10.63442519
90BLK0.62224851
91PDPK10.62052067
92TESK10.61346071
93BTK0.60641504
94MARK20.60296110
95DYRK1B0.58860702
96MAPK40.57440696
97MAPK120.56896939
98PAK10.56729240
99SIK30.56275098
100CSF1R0.56239593
101STK40.55800615
102ADRBK10.55746428
103PKN10.55681886
104IKBKB0.55131532
105CDK80.53910281
106PIM10.52646621
107SIK20.52238417
108ROCK20.50624361
109SYK0.49919805
110MUSK0.49573516
111HIPK20.49554024
112PDK10.49330898
113GRK10.49139052
114ADRBK20.48145087
115GRK50.48090421
116OBSCN0.46821316
117PRKD20.46334101
118TYK20.45839497
119MAP3K80.45151752
120MOS0.44605602
121JAK20.43521610
122CSNK1G30.43507082
123MAPKAPK20.43214781
124MAP3K120.42974745
125NLK0.42560875
126MAP3K140.42440558
127ITK0.41042266
128FES0.41037860
129LCK0.40874713
130NEK20.40799488
131RPS6KC10.39344691
132RPS6KL10.39344691
133IRAK20.39013960
134BCR0.38638660
135MAPK130.38504686
136MKNK20.38315413
137PRKCI0.38313639
138KIT0.37910482
139TTK0.37883303
140LYN0.37106921
141RPS6KA60.36738226
142CDK120.36703796
143CLK10.36299478
144CHEK20.35627399
145STK240.35606036
146PAK40.35420420
147RPS6KA10.33777702
148CAMKK10.32837912
149PRKCD0.31841805
150TEC0.31804842

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030109.07629090
2Oxidative phosphorylation_Homo sapiens_hsa001904.21543567
3Parkinsons disease_Homo sapiens_hsa050123.68690140
4Proteasome_Homo sapiens_hsa030503.65391926
5RNA polymerase_Homo sapiens_hsa030203.25146567
6Huntingtons disease_Homo sapiens_hsa050162.76597347
7Alzheimers disease_Homo sapiens_hsa050102.73221361
8Spliceosome_Homo sapiens_hsa030402.68276245
9DNA replication_Homo sapiens_hsa030302.45941543
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.41199500
11Mismatch repair_Homo sapiens_hsa034302.18688047
12Protein export_Homo sapiens_hsa030602.00482172
13Pyrimidine metabolism_Homo sapiens_hsa002401.95993464
14Leishmaniasis_Homo sapiens_hsa051401.82756245
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.81542169
16Nucleotide excision repair_Homo sapiens_hsa034201.79992192
17Osteoclast differentiation_Homo sapiens_hsa043801.72145539
18Homologous recombination_Homo sapiens_hsa034401.67103107
19B cell receptor signaling pathway_Homo sapiens_hsa046621.66019240
20Cardiac muscle contraction_Homo sapiens_hsa042601.65723838
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.61504313
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61033984
23Acute myeloid leukemia_Homo sapiens_hsa052211.46549133
24RNA transport_Homo sapiens_hsa030131.41659029
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.38561313
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34465548
27Staphylococcus aureus infection_Homo sapiens_hsa051501.33522959
28Malaria_Homo sapiens_hsa051441.29852104
29Base excision repair_Homo sapiens_hsa034101.27456058
30Other glycan degradation_Homo sapiens_hsa005111.20022615
31Systemic lupus erythematosus_Homo sapiens_hsa053221.19106887
32Basal transcription factors_Homo sapiens_hsa030221.18597460
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16065783
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15652400
35Measles_Homo sapiens_hsa051621.15305875
36Type I diabetes mellitus_Homo sapiens_hsa049401.10335897
37RNA degradation_Homo sapiens_hsa030181.04632081
38Tuberculosis_Homo sapiens_hsa051521.02505518
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02451716
40Non-small cell lung cancer_Homo sapiens_hsa052230.98020468
41Fanconi anemia pathway_Homo sapiens_hsa034600.96256903
42Influenza A_Homo sapiens_hsa051640.91414757
43Glutathione metabolism_Homo sapiens_hsa004800.86845377
44Primary immunodeficiency_Homo sapiens_hsa053400.86681778
45Chronic myeloid leukemia_Homo sapiens_hsa052200.86547341
46Toxoplasmosis_Homo sapiens_hsa051450.86089738
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85660338
48Purine metabolism_Homo sapiens_hsa002300.84557974
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84014249
50Chemokine signaling pathway_Homo sapiens_hsa040620.83962729
51Fatty acid elongation_Homo sapiens_hsa000620.81131067
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80025399
53Pancreatic cancer_Homo sapiens_hsa052120.79161331
54VEGF signaling pathway_Homo sapiens_hsa043700.77945111
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77934286
56Non-homologous end-joining_Homo sapiens_hsa034500.77509104
57Shigellosis_Homo sapiens_hsa051310.76765158
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76400947
59Pentose phosphate pathway_Homo sapiens_hsa000300.75811974
60Hepatitis B_Homo sapiens_hsa051610.74550241
61Arachidonic acid metabolism_Homo sapiens_hsa005900.74195202
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73026469
63Phagosome_Homo sapiens_hsa041450.72618859
64p53 signaling pathway_Homo sapiens_hsa041150.72064660
65Epstein-Barr virus infection_Homo sapiens_hsa051690.71384147
66Legionellosis_Homo sapiens_hsa051340.70055681
67Cell cycle_Homo sapiens_hsa041100.69514152
68One carbon pool by folate_Homo sapiens_hsa006700.69197672
69Linoleic acid metabolism_Homo sapiens_hsa005910.68355808
70African trypanosomiasis_Homo sapiens_hsa051430.68219055
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67987980
72Renal cell carcinoma_Homo sapiens_hsa052110.67170259
73Bladder cancer_Homo sapiens_hsa052190.62004909
74Sulfur relay system_Homo sapiens_hsa041220.62000287
75Asthma_Homo sapiens_hsa053100.57978068
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54450644
77Allograft rejection_Homo sapiens_hsa053300.53492527
78Graft-versus-host disease_Homo sapiens_hsa053320.52525045
79Collecting duct acid secretion_Homo sapiens_hsa049660.51925038
80HIF-1 signaling pathway_Homo sapiens_hsa040660.50525504
81Hematopoietic cell lineage_Homo sapiens_hsa046400.50351314
82Tyrosine metabolism_Homo sapiens_hsa003500.50006662
83Alcoholism_Homo sapiens_hsa050340.49904690
84Thyroid cancer_Homo sapiens_hsa052160.49180791
85Salmonella infection_Homo sapiens_hsa051320.48557941
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48171278
87Basal cell carcinoma_Homo sapiens_hsa052170.47730636
88Metabolic pathways_Homo sapiens_hsa011000.47646688
89Autoimmune thyroid disease_Homo sapiens_hsa053200.47604635
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47543425
91TNF signaling pathway_Homo sapiens_hsa046680.47320877
92Hepatitis C_Homo sapiens_hsa051600.45672023
93Fructose and mannose metabolism_Homo sapiens_hsa000510.45202437
94Phenylalanine metabolism_Homo sapiens_hsa003600.44258671
95Colorectal cancer_Homo sapiens_hsa052100.44124502
96Ether lipid metabolism_Homo sapiens_hsa005650.42705768
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.42618243
98mRNA surveillance pathway_Homo sapiens_hsa030150.42554717
99Sphingolipid metabolism_Homo sapiens_hsa006000.41809752
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41209552
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40710843
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39413612
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39168007
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38691833
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.38566872
106Endocytosis_Homo sapiens_hsa041440.37874823
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37107647
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36589229
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.35442618
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34958479
111Galactose metabolism_Homo sapiens_hsa000520.34839133
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33664853
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32956931
114Steroid biosynthesis_Homo sapiens_hsa001000.32143721
115Lysosome_Homo sapiens_hsa041420.31450499
116Hedgehog signaling pathway_Homo sapiens_hsa043400.31382759
117Folate biosynthesis_Homo sapiens_hsa007900.30170642
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29909876
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29855018
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29389649
121Viral carcinogenesis_Homo sapiens_hsa052030.28844410
122Pertussis_Homo sapiens_hsa051330.28723262
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27704269
124Prion diseases_Homo sapiens_hsa050200.27032940
125Chemical carcinogenesis_Homo sapiens_hsa052040.25832794
126Herpes simplex infection_Homo sapiens_hsa051680.25786133
127Endometrial cancer_Homo sapiens_hsa052130.25255450
128Arginine and proline metabolism_Homo sapiens_hsa003300.24162861
129Notch signaling pathway_Homo sapiens_hsa043300.24032128
130Viral myocarditis_Homo sapiens_hsa054160.22118773
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21790016
132Antigen processing and presentation_Homo sapiens_hsa046120.21634413
133Phototransduction_Homo sapiens_hsa047440.21531636
134HTLV-I infection_Homo sapiens_hsa051660.19913328
135Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17068357
136Small cell lung cancer_Homo sapiens_hsa052220.11736145
137Pathways in cancer_Homo sapiens_hsa052000.11152776
138Sulfur metabolism_Homo sapiens_hsa009200.10317451
139NF-kappa B signaling pathway_Homo sapiens_hsa040640.09641072
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.09119515
141Apoptosis_Homo sapiens_hsa042100.08204089
142Tight junction_Homo sapiens_hsa045300.08095500
143Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.07834732
144Histidine metabolism_Homo sapiens_hsa003400.07737939
145Drug metabolism - other enzymes_Homo sapiens_hsa009830.07494111
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.07087486
147Rheumatoid arthritis_Homo sapiens_hsa053230.06868553
148T cell receptor signaling pathway_Homo sapiens_hsa046600.06148222
149TGF-beta signaling pathway_Homo sapiens_hsa043500.06137275
150Retinol metabolism_Homo sapiens_hsa008300.05528233
151MicroRNAs in cancer_Homo sapiens_hsa052060.03187579
152Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.02616704

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