UBA52P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.89736887
2positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.65542372
3regulation of activation of Janus kinase activity (GO:0010533)5.31540459
4ribosomal small subunit assembly (GO:0000028)4.99670163
5regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.87710055
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.75947528
7ATP synthesis coupled proton transport (GO:0015986)4.49837253
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.49837253
9GTP biosynthetic process (GO:0006183)4.32065708
10maturation of SSU-rRNA (GO:0030490)4.31631330
11regulation of regulatory T cell differentiation (GO:0045589)4.25113553
12cytidine deamination (GO:0009972)4.19804360
13cytidine metabolic process (GO:0046087)4.19804360
14cytidine catabolic process (GO:0006216)4.19804360
15viral transcription (GO:0019083)4.10101537
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.07520524
17chaperone-mediated protein transport (GO:0072321)4.03373207
18positive regulation of interleukin-17 production (GO:0032740)3.97335631
19protein neddylation (GO:0045116)3.95041522
20translational termination (GO:0006415)3.93366467
21protein complex biogenesis (GO:0070271)3.92019070
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.87244933
23regulation of memory T cell differentiation (GO:0043380)3.83439398
24ribosomal small subunit biogenesis (GO:0042274)3.82367137
25ribosomal large subunit biogenesis (GO:0042273)3.77729947
26negative regulation of heart rate (GO:0010459)3.74029348
27respiratory electron transport chain (GO:0022904)3.67555869
28regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.65168286
29electron transport chain (GO:0022900)3.65150370
30positive regulation of cell fate commitment (GO:0010455)3.62757905
31UTP biosynthetic process (GO:0006228)3.60806580
32regulation of mitochondrial translation (GO:0070129)3.60563988
33positive regulation of action potential (GO:0045760)3.59615253
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.56778863
35cotranslational protein targeting to membrane (GO:0006613)3.55569606
36pyrimidine ribonucleoside catabolic process (GO:0046133)3.54637856
37purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.53610605
38protein targeting to ER (GO:0045047)3.52078234
39translational elongation (GO:0006414)3.51134935
40purine nucleoside triphosphate biosynthetic process (GO:0009145)3.47635418
41regulation of immunoglobulin secretion (GO:0051023)3.45462135
42mitochondrial respiratory chain complex assembly (GO:0033108)3.44756370
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.39642886
44NADH dehydrogenase complex assembly (GO:0010257)3.39642886
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.39642886
46nucleoside diphosphate phosphorylation (GO:0006165)3.37328228
47establishment of protein localization to endoplasmic reticulum (GO:0072599)3.35987111
48protein localization to endoplasmic reticulum (GO:0070972)3.32358121
49positive regulation of defense response to virus by host (GO:0002230)3.30994754
50positive regulation of T-helper 1 type immune response (GO:0002827)3.30326513
51ATP biosynthetic process (GO:0006754)3.28835309
52tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.28710175
53RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.28710175
54regulation of action potential (GO:0098900)3.26035903
55tachykinin receptor signaling pathway (GO:0007217)3.21783167
56positive regulation of T cell mediated cytotoxicity (GO:0001916)3.20395840
57regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.18008134
58UTP metabolic process (GO:0046051)3.14511159
59positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.06047236
60platelet dense granule organization (GO:0060155)3.05041700
61negative regulation of mast cell activation (GO:0033004)3.03782108
62cellular component biogenesis (GO:0044085)2.98161308
63cellular protein complex disassembly (GO:0043624)2.96458295
64ribonucleoside triphosphate biosynthetic process (GO:0009201)2.96271013
65ribonucleoprotein complex biogenesis (GO:0022613)2.95292103
66positive regulation of calcium-mediated signaling (GO:0050850)2.91125075
67regulation of interleukin-12 biosynthetic process (GO:0045075)2.90324017
68translation (GO:0006412)2.88816626
69behavioral response to nicotine (GO:0035095)2.86303355
70base-excision repair, AP site formation (GO:0006285)2.85901832
71viral life cycle (GO:0019058)2.85077794
72motile cilium assembly (GO:0044458)2.83968751
73positive regulation of activated T cell proliferation (GO:0042104)2.83354272
74ubiquinone biosynthetic process (GO:0006744)2.82306324
75negative regulation of T cell differentiation in thymus (GO:0033085)2.80611498
76negative regulation by host of viral transcription (GO:0043922)2.79983579
77proteasome assembly (GO:0043248)2.79426402
78heme transport (GO:0015886)2.78393147
79regulation of isotype switching to IgG isotypes (GO:0048302)2.77328440
80intracellular protein transmembrane import (GO:0044743)2.76951925
81regulation of cellular amino acid metabolic process (GO:0006521)2.76501416
82nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.75088755
83positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.74228239
84guanosine-containing compound biosynthetic process (GO:1901070)2.74053442
85L-fucose catabolic process (GO:0042355)2.73046334
86fucose catabolic process (GO:0019317)2.73046334
87L-fucose metabolic process (GO:0042354)2.73046334
88positive regulation of tolerance induction (GO:0002645)2.72818408
89translational initiation (GO:0006413)2.70768874
90CTP metabolic process (GO:0046036)2.69984586
91CTP biosynthetic process (GO:0006241)2.69984586
92epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.69855233
93nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69258664
94negative regulation of calcium ion transport into cytosol (GO:0010523)2.68572703
95regulation of gamma-delta T cell differentiation (GO:0045586)2.67401571
96regulation of T cell mediated cytotoxicity (GO:0001914)2.66380350
97regulation of chronic inflammatory response (GO:0002676)2.65026670
98monocyte chemotaxis (GO:0002548)2.64908723
99ubiquinone metabolic process (GO:0006743)2.64791318
100cellular response to nicotine (GO:0071316)2.63843052

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.07902376
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.33576456
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.29386993
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.91265705
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.15823713
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.05224914
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90411948
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.71292395
9VDR_22108803_ChIP-Seq_LS180_Human2.66823527
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.66790813
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.59336557
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.53964649
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.35036637
14VDR_23849224_ChIP-Seq_CD4+_Human2.24416527
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16943976
16ZNF274_21170338_ChIP-Seq_K562_Hela2.12392625
17ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99036442
18IRF1_19129219_ChIP-ChIP_H3396_Human1.89986597
19FOXP3_21729870_ChIP-Seq_TREG_Human1.88304007
20ELK1_19687146_ChIP-ChIP_HELA_Human1.82512245
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.81203566
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.78223661
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77152363
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.76596153
25EGR1_23403033_ChIP-Seq_LIVER_Mouse1.74182546
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66533446
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.63130713
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.62075153
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61404982
30TP53_22573176_ChIP-Seq_HFKS_Human1.60293401
31MYC_18940864_ChIP-ChIP_HL60_Human1.55969466
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55096005
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.51681528
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51296588
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.48056753
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47260311
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40449304
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38465814
39FOXA1_27270436_Chip-Seq_PROSTATE_Human1.38135131
40FOXA1_25329375_ChIP-Seq_VCAP_Human1.38135131
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35614826
42GBX2_23144817_ChIP-Seq_PC3_Human1.35189593
43TTF2_22483619_ChIP-Seq_HELA_Human1.34831013
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34569214
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33507848
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.32289381
47SOX2_16153702_ChIP-ChIP_HESCs_Human1.31399979
48PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.30295567
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.29839608
50MYC_19829295_ChIP-Seq_ESCs_Human1.26787100
51TAF2_19829295_ChIP-Seq_ESCs_Human1.25951119
52RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.25689307
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24352212
54EWS_26573619_Chip-Seq_HEK293_Human1.23972196
55ER_23166858_ChIP-Seq_MCF-7_Human1.21846947
56PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.21536651
57EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20945501
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.19047072
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17039002
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.17026611
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16887147
62MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15613391
63FUS_26573619_Chip-Seq_HEK293_Human1.13182385
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13170134
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12033952
66AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10398561
67IRF8_21731497_ChIP-ChIP_J774_Mouse1.10288233
68TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08851980
69GABP_19822575_ChIP-Seq_HepG2_Human1.08084060
70YY1_22570637_ChIP-Seq_MALME-3M_Human1.06926943
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06870020
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05174859
73XRN2_22483619_ChIP-Seq_HELA_Human1.03963460
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03393889
75TAF15_26573619_Chip-Seq_HEK293_Human1.03229297
76FOXH1_21741376_ChIP-Seq_EPCs_Human1.01350746
77IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01348189
78HOXB7_26014856_ChIP-Seq_BT474_Human1.00300879
79NANOG_20526341_ChIP-Seq_ESCs_Human0.99969310
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99064435
81STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98771924
82CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97833178
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97688982
84DCP1A_22483619_ChIP-Seq_HELA_Human0.95785803
85NCOR_22424771_ChIP-Seq_293T_Human0.94732804
86GATA3_26560356_Chip-Seq_TH2_Human0.94722737
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93298403
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92649153
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92298424
90EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91838711
91PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91356877
92NANOG_19829295_ChIP-Seq_ESCs_Human0.91018610
93SOX2_19829295_ChIP-Seq_ESCs_Human0.91018610
94PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90904652
95CTCF_20526341_ChIP-Seq_ESCs_Human0.90812372
96GATA3_27048872_Chip-Seq_THYMUS_Human0.90420305
97NANOG_16153702_ChIP-ChIP_HESCs_Human0.89542031
98POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88725494
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88539172
100P300_27268052_Chip-Seq_Bcells_Human0.88012741

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.68053915
2MP0003878_abnormal_ear_physiology3.45828038
3MP0005377_hearing/vestibular/ear_phenot3.45828038
4MP0002102_abnormal_ear_morphology3.08558098
5MP0010386_abnormal_urinary_bladder3.06025512
6MP0008875_abnormal_xenobiotic_pharmacok2.74450175
7MP0009379_abnormal_foot_pigmentation2.65684967
8MP0006292_abnormal_olfactory_placode2.36991532
9MP0003195_calcinosis2.35572313
10MP0004885_abnormal_endolymph2.29863204
11MP0003045_fibrosis2.28926265
12MP0002653_abnormal_ependyma_morphology2.19795645
13MP0008877_abnormal_DNA_methylation2.06938232
14MP0008872_abnormal_physiological_respon1.99208558
15MP0005084_abnormal_gallbladder_morpholo1.96439824
16MP0009785_altered_susceptibility_to1.91562963
17MP0002736_abnormal_nociception_after1.90016517
18MP0004742_abnormal_vestibular_system1.83569715
19MP0003866_abnormal_defecation1.83159477
20MP0001485_abnormal_pinna_reflex1.82145049
21MP0001968_abnormal_touch/_nociception1.74141652
22MP0001529_abnormal_vocalization1.72120683
23MP0002277_abnormal_respiratory_mucosa1.67723202
24MP0004145_abnormal_muscle_electrophysio1.66588198
25MP0001984_abnormal_olfaction1.62378390
26MP0009333_abnormal_splenocyte_physiolog1.61365280
27MP0001835_abnormal_antigen_presentation1.58114519
28MP0003787_abnormal_imprinting1.56338077
29MP0005075_abnormal_melanosome_morpholog1.50941880
30MP0001905_abnormal_dopamine_level1.46367388
31MP0002735_abnormal_chemical_nociception1.46085992
32MP0003011_delayed_dark_adaptation1.45665131
33MP0003786_premature_aging1.44877030
34MP0005423_abnormal_somatic_nervous1.44213778
35MP0008789_abnormal_olfactory_epithelium1.44167242
36MP0002163_abnormal_gland_morphology1.40810011
37MP0003646_muscle_fatigue1.40606162
38MP0005646_abnormal_pituitary_gland1.38873642
39MP0002138_abnormal_hepatobiliary_system1.32897299
40MP0004147_increased_porphyrin_level1.30648607
41MP0002837_dystrophic_cardiac_calcinosis1.30247654
42MP0001800_abnormal_humoral_immune1.28149480
43MP0001790_abnormal_immune_system1.25489456
44MP0005387_immune_system_phenotype1.25489456
45MP0005645_abnormal_hypothalamus_physiol1.22608711
46MP0004142_abnormal_muscle_tone1.20626337
47MP0005551_abnormal_eye_electrophysiolog1.15538460
48MP0002160_abnormal_reproductive_system1.13993133
49MP0003879_abnormal_hair_cell1.12474471
50MP0005394_taste/olfaction_phenotype1.12381776
51MP0005499_abnormal_olfactory_system1.12381776
52MP0001853_heart_inflammation1.10611861
53MP0001873_stomach_inflammation1.10352504
54MP0002272_abnormal_nervous_system1.09219326
55MP0003122_maternal_imprinting1.08727511
56MP0005000_abnormal_immune_tolerance1.06849671
57MP0003123_paternal_imprinting1.06028157
58MP0005636_abnormal_mineral_homeostasis1.04999946
59MP0005389_reproductive_system_phenotype1.04851474
60MP0001764_abnormal_homeostasis1.04691160
61MP0005379_endocrine/exocrine_gland_phen1.03892449
62MP0006054_spinal_hemorrhage1.03299011
63MP0002938_white_spotting1.03041997
64MP0001919_abnormal_reproductive_system1.02259341
65MP0009745_abnormal_behavioral_response1.02032659
66MP0001348_abnormal_lacrimal_gland0.99849208
67MP0002723_abnormal_immune_serum0.99588307
68MP0005410_abnormal_fertilization0.95261602
69MP0003567_abnormal_fetal_cardiomyocyte0.95257715
70MP0002148_abnormal_hypersensitivity_rea0.94904755
71MP0005670_abnormal_white_adipose0.93570768
72MP0001963_abnormal_hearing_physiology0.92534970
73MP0002405_respiratory_system_inflammati0.89865643
74MP0003763_abnormal_thymus_physiology0.87487239
75MP0001188_hyperpigmentation0.86482016
76MP0000049_abnormal_middle_ear0.85310621
77MP0006072_abnormal_retinal_apoptosis0.84147764
78MP0002693_abnormal_pancreas_physiology0.83582928
79MP0004133_heterotaxia0.82873982
80MP0002420_abnormal_adaptive_immunity0.82772242
81MP0003718_maternal_effect0.80185823
82MP0005025_abnormal_response_to0.80009507
83MP0002234_abnormal_pharynx_morphology0.79728023
84MP0000026_abnormal_inner_ear0.77791735
85MP0001819_abnormal_immune_cell0.77491303
86MP0010368_abnormal_lymphatic_system0.76288623
87MP0003638_abnormal_response/metabolism_0.75753364
88MP0000613_abnormal_salivary_gland0.73285893
89MP0000538_abnormal_urinary_bladder0.73202593
90MP0000685_abnormal_immune_system0.71033132
91MP0001970_abnormal_pain_threshold0.70996606
92MP0006276_abnormal_autonomic_nervous0.70436360
93MP0009643_abnormal_urine_homeostasis0.70357507
94MP0002876_abnormal_thyroid_physiology0.70166664
95MP0002733_abnormal_thermal_nociception0.69709231
96MP0005360_urolithiasis0.69487565
97MP0005408_hypopigmentation0.66803496
98MP0001663_abnormal_digestive_system0.66200953
99MP0010155_abnormal_intestine_physiology0.65508309
100MP0001486_abnormal_startle_reflex0.65018462

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.29203256
2Increased IgM level (HP:0003496)4.28879454
3Abnormal mitochondria in muscle tissue (HP:0008316)4.13523524
4Mitochondrial inheritance (HP:0001427)3.97403976
5Renal Fanconi syndrome (HP:0001994)3.67618613
6Progressive macrocephaly (HP:0004481)3.60469971
7Increased CSF lactate (HP:0002490)3.58741647
8Stomatitis (HP:0010280)3.57832161
9Acute encephalopathy (HP:0006846)3.53363889
10Hepatocellular necrosis (HP:0001404)3.38478466
11Abnormality of T cell number (HP:0011839)3.38141698
123-Methylglutaconic aciduria (HP:0003535)3.32820001
13IgG deficiency (HP:0004315)3.29361887
14Pancreatic cysts (HP:0001737)3.24161998
15Abnormality of the renal cortex (HP:0011035)3.23654977
16Molar tooth sign on MRI (HP:0002419)3.23079225
17Abnormality of midbrain morphology (HP:0002418)3.23079225
18Hepatic necrosis (HP:0002605)3.17522358
19Increased hepatocellular lipid droplets (HP:0006565)3.13280664
20Colon cancer (HP:0003003)3.09070126
21Absent rod-and cone-mediated responses on ERG (HP:0007688)3.01437211
22Increased intramyocellular lipid droplets (HP:0012240)2.97481212
23Lipid accumulation in hepatocytes (HP:0006561)2.95153799
24Generalized aminoaciduria (HP:0002909)2.92700116
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.91760278
26Decreased activity of mitochondrial respiratory chain (HP:0008972)2.91760278
27Type II lissencephaly (HP:0007260)2.86564203
28Renal cortical cysts (HP:0000803)2.80834234
29Cerebral edema (HP:0002181)2.80037855
30Retrobulbar optic neuritis (HP:0100654)2.78051111
31Optic neuritis (HP:0100653)2.78051111
32Nephronophthisis (HP:0000090)2.75118526
33Congenital stationary night blindness (HP:0007642)2.73029797
34Abnormality of cells of the erythroid lineage (HP:0012130)2.72832384
35Pancreatic fibrosis (HP:0100732)2.69145926
36Aplastic anemia (HP:0001915)2.66451675
37Tubular atrophy (HP:0000092)2.62399727
38Stomach cancer (HP:0012126)2.59662702
39Hypochromic anemia (HP:0001931)2.50158656
40True hermaphroditism (HP:0010459)2.50113478
41Abnormality of T cells (HP:0002843)2.49446159
42Abnormal number of erythroid precursors (HP:0012131)2.49235903
43T lymphocytopenia (HP:0005403)2.49223263
44Hypophosphatemic rickets (HP:0004912)2.48878289
45Increased muscle lipid content (HP:0009058)2.47059559
46Medial flaring of the eyebrow (HP:0010747)2.42457783
47Abnormality of the renal medulla (HP:0100957)2.41678615
48Lactic acidosis (HP:0003128)2.40014463
49Optic disc pallor (HP:0000543)2.36276831
50Hypoproteinemia (HP:0003075)2.35553759
51Abnormal drinking behavior (HP:0030082)2.33612872
52Polydipsia (HP:0001959)2.33612872
53Reticulocytopenia (HP:0001896)2.33531179
54Septo-optic dysplasia (HP:0100842)2.31263375
55Increased serum lactate (HP:0002151)2.30339115
56Macrocytic anemia (HP:0001972)2.29959517
57Abnormal delayed hypersensitivity skin test (HP:0002963)2.27269862
58Decreased electroretinogram (ERG) amplitude (HP:0000654)2.23314111
59Orchitis (HP:0100796)2.19944303
60Absent thumb (HP:0009777)2.19722378
61Respiratory failure (HP:0002878)2.16670420
62Abnormal rod and cone electroretinograms (HP:0008323)2.15483384
63Autoimmune thrombocytopenia (HP:0001973)2.14739470
64Abnormality of renal resorption (HP:0011038)2.11726527
65Abnormality of T cell physiology (HP:0011840)2.11140792
66Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.08396817
67Absent/shortened dynein arms (HP:0200106)2.07820259
68Dynein arm defect of respiratory motile cilia (HP:0012255)2.07820259
69Myositis (HP:0100614)2.07803879
70Decreased central vision (HP:0007663)2.07267801
71Glycosuria (HP:0003076)2.04520894
72Abnormality of urine glucose concentration (HP:0011016)2.04520894
73Abnormality of alanine metabolism (HP:0010916)2.04218244
74Hyperalaninemia (HP:0003348)2.04218244
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04218244
76Exertional dyspnea (HP:0002875)2.03186787
77Abnormality of eosinophils (HP:0001879)2.02112645
78Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.00252469
79Sclerocornea (HP:0000647)1.99669927
80Methylmalonic aciduria (HP:0012120)1.98847840
81Abolished electroretinogram (ERG) (HP:0000550)1.98208313
82Abnormality of aspartate family amino acid metabolism (HP:0010899)1.95637833
83Abnormality of B cell number (HP:0010975)1.94059152
84Polyuria (HP:0000103)1.92146562
85Hypergammaglobulinemia (HP:0010702)1.92139000
86Hypochromic microcytic anemia (HP:0004840)1.88846087
87Methylmalonic acidemia (HP:0002912)1.88454593
88Leukodystrophy (HP:0002415)1.86863393
89Exercise intolerance (HP:0003546)1.85444963
90Cystic liver disease (HP:0006706)1.84862443
91Severe combined immunodeficiency (HP:0004430)1.81557223
92Autoimmune hemolytic anemia (HP:0001890)1.81096966
93Attenuation of retinal blood vessels (HP:0007843)1.78064640
94Abnormality of serum amino acid levels (HP:0003112)1.76227220
95Elevated erythrocyte sedimentation rate (HP:0003565)1.75907424
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.74234034
97Hypoplasia of the pons (HP:0012110)1.72637180
98Pendular nystagmus (HP:0012043)1.72340613
99Rib fusion (HP:0000902)1.71436472
100Porencephaly (HP:0002132)1.70610922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.60800243
2ZAK3.65924378
3KDR3.35610761
4VRK23.29696544
5NUAK12.85970663
6TLK12.84011277
7CDK192.68772816
8TIE12.56063819
9VRK12.32584252
10ADRBK22.32000741
11PINK12.29736779
12GRK12.27202514
13NME12.25054118
14FRK2.20758143
15PASK2.20205807
16MAP4K12.15313652
17BUB12.11876291
18PIK3CA1.66039740
19NME21.52106690
20BCKDK1.43923830
21ITK1.41454875
22TEC1.39792299
23RPS6KA51.36388139
24TSSK61.29955690
25PRKCQ1.24725330
26TAOK31.13823812
27BMPR1B1.13710643
28INSRR1.08232779
29FES1.04937641
30PNCK1.04556549
31TRIM281.03870765
32WEE11.03088802
33TESK21.01697691
34WNK30.97999888
35IKBKB0.94758735
36OXSR10.94027369
37MST40.90622240
38PLK30.89682621
39DYRK20.89180866
40AURKA0.88773182
41MAP4K20.88681522
42CDC70.88326797
43PLK40.88032664
44STK40.87924814
45MARK30.85785768
46CSNK1G30.79164936
47CSK0.78535723
48NEK10.75933707
49IRAK40.74207963
50PHKG20.74156682
51PHKG10.74156682
52PBK0.73448819
53CSNK1G20.72560302
54LCK0.65099935
55DAPK30.63784635
56LYN0.61957252
57WNK40.59831353
58EPHA40.59679232
59ROCK10.58309981
60ATR0.57331774
61CSNK1G10.56461839
62CAMKK20.55433929
63IKBKE0.55019442
64PRKCG0.54503682
65ALK0.53976327
66ZAP700.53864094
67TAF10.53490052
68CHUK0.52754845
69BCR0.52394719
70STK30.51368989
71PLK10.48220157
72SYK0.47801152
73CSNK2A20.47489213
74IGF1R0.47075966
75AURKB0.46979914
76GRK60.45206731
77PRKACA0.44254976
78ADRBK10.44033300
79LIMK10.43274586
80OBSCN0.43233498
81MATK0.41886164
82NTRK30.41424541
83MAPKAPK50.41019608
84CSNK2A10.40749573
85PRKCI0.40299811
86CAMK10.39376322
87STK160.39110058
88ERBB20.38726876
89PRKCA0.37743644
90DAPK20.37477110
91PRKCE0.34905188
92BTK0.34517629
93CSNK1A1L0.33857069
94CAMK2A0.33253645
95TAOK10.33248461
96CSNK1A10.32433948
97MAPK150.30668786
98PAK30.29274516
99GRK50.28697255
100NTRK20.27789839

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.98783480
2Oxidative phosphorylation_Homo sapiens_hsa001903.63863220
3Primary immunodeficiency_Homo sapiens_hsa053403.46763624
4Proteasome_Homo sapiens_hsa030503.45482216
5Parkinsons disease_Homo sapiens_hsa050122.80835986
6Autoimmune thyroid disease_Homo sapiens_hsa053202.28075756
7RNA polymerase_Homo sapiens_hsa030202.21647198
8Systemic lupus erythematosus_Homo sapiens_hsa053222.21344426
9Allograft rejection_Homo sapiens_hsa053302.18444409
10Graft-versus-host disease_Homo sapiens_hsa053322.11778423
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.06140338
12Protein export_Homo sapiens_hsa030601.93897753
13Huntingtons disease_Homo sapiens_hsa050161.89267188
14Type I diabetes mellitus_Homo sapiens_hsa049401.88703196
15Alzheimers disease_Homo sapiens_hsa050101.86433058
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.80589903
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75828037
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.71595408
19Nitrogen metabolism_Homo sapiens_hsa009101.61099197
20Antigen processing and presentation_Homo sapiens_hsa046121.58410415
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57790337
22Caffeine metabolism_Homo sapiens_hsa002321.55350374
23Asthma_Homo sapiens_hsa053101.54890860
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53942958
25Cardiac muscle contraction_Homo sapiens_hsa042601.51701288
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50745097
27Hematopoietic cell lineage_Homo sapiens_hsa046401.49176005
28Rheumatoid arthritis_Homo sapiens_hsa053231.38755940
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.37149431
30Phototransduction_Homo sapiens_hsa047441.33313518
31Pyrimidine metabolism_Homo sapiens_hsa002401.30625417
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29351479
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28269853
34Homologous recombination_Homo sapiens_hsa034401.25843462
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23114989
36T cell receptor signaling pathway_Homo sapiens_hsa046601.12051402
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11046529
38Alcoholism_Homo sapiens_hsa050341.06621552
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02195254
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01406365
41Selenocompound metabolism_Homo sapiens_hsa004501.00609171
42RNA degradation_Homo sapiens_hsa030180.99856855
43One carbon pool by folate_Homo sapiens_hsa006700.99658567
44Linoleic acid metabolism_Homo sapiens_hsa005910.98344394
45Spliceosome_Homo sapiens_hsa030400.96790431
46Basal transcription factors_Homo sapiens_hsa030220.94175096
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93990587
48Fanconi anemia pathway_Homo sapiens_hsa034600.93173360
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92579980
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90593990
51Tryptophan metabolism_Homo sapiens_hsa003800.86705967
52Purine metabolism_Homo sapiens_hsa002300.86301917
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86227765
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86189238
55Propanoate metabolism_Homo sapiens_hsa006400.84922330
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.83014573
57Peroxisome_Homo sapiens_hsa041460.82627047
58RNA transport_Homo sapiens_hsa030130.81855025
59DNA replication_Homo sapiens_hsa030300.81728250
60Chemical carcinogenesis_Homo sapiens_hsa052040.81087208
61Base excision repair_Homo sapiens_hsa034100.78909154
62Butanoate metabolism_Homo sapiens_hsa006500.77672997
63Mismatch repair_Homo sapiens_hsa034300.77437358
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76538865
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75871976
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73507337
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73193783
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72501651
69Nucleotide excision repair_Homo sapiens_hsa034200.71176490
70Nicotine addiction_Homo sapiens_hsa050330.68710919
71Retinol metabolism_Homo sapiens_hsa008300.63482410
72Fat digestion and absorption_Homo sapiens_hsa049750.62825031
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60913297
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.59578919
75Metabolic pathways_Homo sapiens_hsa011000.59195264
76Sulfur metabolism_Homo sapiens_hsa009200.59176523
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58787347
78Fatty acid degradation_Homo sapiens_hsa000710.58440858
79Tyrosine metabolism_Homo sapiens_hsa003500.56508665
80Vitamin digestion and absorption_Homo sapiens_hsa049770.53024451
81Steroid biosynthesis_Homo sapiens_hsa001000.52147450
82Collecting duct acid secretion_Homo sapiens_hsa049660.51901591
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.51117730
84Glutathione metabolism_Homo sapiens_hsa004800.46294569
85Olfactory transduction_Homo sapiens_hsa047400.45788992
86Viral myocarditis_Homo sapiens_hsa054160.41485178
87Regulation of autophagy_Homo sapiens_hsa041400.40276457
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40087113
89Arginine biosynthesis_Homo sapiens_hsa002200.39256197
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39138540
91Measles_Homo sapiens_hsa051620.36758779
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36007371
93Vitamin B6 metabolism_Homo sapiens_hsa007500.33744772
94Arachidonic acid metabolism_Homo sapiens_hsa005900.33233662
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31957983
96N-Glycan biosynthesis_Homo sapiens_hsa005100.29024897
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27603596
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.26162903
99Pyruvate metabolism_Homo sapiens_hsa006200.21927939
100beta-Alanine metabolism_Homo sapiens_hsa004100.21355280

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