UBA52P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lens fiber cell development (GO:0070307)9.15643579
2positive regulation of isotype switching (GO:0045830)7.19667703
3dopamine transport (GO:0015872)6.65914531
4positive regulation of DNA recombination (GO:0045911)6.55855748
5activated T cell proliferation (GO:0050798)6.26802305
6base-excision repair, AP site formation (GO:0006285)6.10453734
7positive regulation of immunoglobulin mediated immune response (GO:0002891)5.11889328
8positive regulation of B cell mediated immunity (GO:0002714)5.11889328
9pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)5.09337693
10UMP metabolic process (GO:0046049)5.09337693
11pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)5.09337693
12UMP biosynthetic process (GO:0006222)5.09337693
13nucleobase biosynthetic process (GO:0046112)5.09169643
14organic cation transport (GO:0015695)4.79896464
15pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)4.70470697
16arginine catabolic process (GO:0006527)4.66131998
17interferon-gamma production (GO:0032609)4.64880311
18cellular response to exogenous dsRNA (GO:0071360)4.57853978
19ribosomal small subunit assembly (GO:0000028)4.55001941
20histamine transport (GO:0051608)4.53608836
21leukotriene biosynthetic process (GO:0019370)4.47227921
22mast cell degranulation (GO:0043303)4.46991496
23mast cell activation involved in immune response (GO:0002279)4.46991496
24pyrimidine nucleoside monophosphate metabolic process (GO:0009129)4.36487206
25regulation of isotype switching (GO:0045191)4.35353801
26energy coupled proton transport, down electrochemical gradient (GO:0015985)4.19974197
27ATP synthesis coupled proton transport (GO:0015986)4.19974197
28positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.10185576
29positive regulation of immunoglobulin production (GO:0002639)4.08993906
30catecholamine transport (GO:0051937)4.04001786
31cellular response to interferon-beta (GO:0035458)3.66340011
32neurotransmitter uptake (GO:0001504)3.61085171
33drug transmembrane transport (GO:0006855)3.59854442
34regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.55778526
35mast cell activation (GO:0045576)3.47580414
36viral transcription (GO:0019083)3.43593046
37DNA deamination (GO:0045006)3.41792587
38pyrimidine nucleobase metabolic process (GO:0006206)3.38856264
39mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.38713759
40protein neddylation (GO:0045116)3.37754382
41positive regulation of guanylate cyclase activity (GO:0031284)3.37002080
42neural tube formation (GO:0001841)3.32502467
43platelet dense granule organization (GO:0060155)3.31607079
44translational termination (GO:0006415)3.30588309
45regulation of immunoglobulin mediated immune response (GO:0002889)3.29492608
46regulation of appetite (GO:0032098)3.29201035
47lysosome localization (GO:0032418)3.28033604
48negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.26366814
49toxin transport (GO:1901998)3.25643378
50pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.25329469
51lymphocyte migration (GO:0072676)3.25165904
52kidney morphogenesis (GO:0060993)3.18205135
53arginine metabolic process (GO:0006525)3.17284626
54regulation of B cell mediated immunity (GO:0002712)3.15936226
55negative regulation of heart rate (GO:0010459)3.15625836
56purine deoxyribonucleotide catabolic process (GO:0009155)3.13525716
57positive regulation of defense response to virus by host (GO:0002230)3.12086495
58peripheral nervous system neuron development (GO:0048935)3.06357331
59pyrimidine ribonucleotide biosynthetic process (GO:0009220)3.05026213
60regulation of guanylate cyclase activity (GO:0031282)3.03269430
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02763164
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00832164
63positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.00478091
64regulation of immunoglobulin production (GO:0002637)2.97128109
65monoamine transport (GO:0015844)2.89954050
66translational elongation (GO:0006414)2.89639500
67cytidine catabolic process (GO:0006216)2.89120011
68cytidine deamination (GO:0009972)2.89120011
69cytidine metabolic process (GO:0046087)2.89120011
70protein K6-linked ubiquitination (GO:0085020)2.88356546
71pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.87282769
72positive regulation of calcium-mediated signaling (GO:0050850)2.86006166
73protein targeting to ER (GO:0045047)2.85703159
74SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.85673565
75protein polyglutamylation (GO:0018095)2.84053428
76pyrimidine ribonucleoside metabolic process (GO:0046131)2.83125158
77protein localization to cilium (GO:0061512)2.82467000
78cotranslational protein targeting to membrane (GO:0006613)2.82039472
79deoxyribonucleotide catabolic process (GO:0009264)2.77375356
80pyrimidine nucleoside biosynthetic process (GO:0046134)2.76470326
81pyrimidine nucleoside metabolic process (GO:0006213)2.75895633
82azole transport (GO:0045117)2.74637761
83positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.73250599
84maturation of SSU-rRNA (GO:0030490)2.73244281
85RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.72925619
86response to interferon-beta (GO:0035456)2.71689886
87establishment of protein localization to endoplasmic reticulum (GO:0072599)2.70791065
88regulation of NFAT protein import into nucleus (GO:0051532)2.67217562
89positive regulation of lymphocyte mediated immunity (GO:0002708)2.66105763
90protein localization to endoplasmic reticulum (GO:0070972)2.65302831
91pyrimidine ribonucleotide metabolic process (GO:0009218)2.63852515
92positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.63087458
93regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.63087458
94endoderm formation (GO:0001706)2.59192627
95nitric oxide biosynthetic process (GO:0006809)2.58842248
96tachykinin receptor signaling pathway (GO:0007217)2.58833135
97sperm motility (GO:0030317)2.58794491
98axoneme assembly (GO:0035082)2.55770579
99pyrimidine nucleotide biosynthetic process (GO:0006221)2.55176765
100regulation of isotype switching to IgG isotypes (GO:0048302)10.2401509

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.60671329
2STAT6_21828071_ChIP-Seq_BEAS2B_Human5.68585834
3CHD7_19251738_ChIP-ChIP_MESCs_Mouse4.76562028
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.90328833
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.77803717
6EZH2_22144423_ChIP-Seq_EOC_Human2.50938509
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.28412097
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27175670
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00728713
10VDR_22108803_ChIP-Seq_LS180_Human1.97497254
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95548802
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86867207
13EST1_17652178_ChIP-ChIP_JURKAT_Human1.77829566
14ZNF274_21170338_ChIP-Seq_K562_Hela1.63959536
15EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60435088
16BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59343783
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58261215
18BP1_19119308_ChIP-ChIP_Hs578T_Human1.57607106
19TDRD3_21172665_ChIP-Seq_MCF-7_Human1.50277822
20GATA3_26560356_Chip-Seq_TH2_Human1.50104139
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46556252
22FOXA1_27270436_Chip-Seq_PROSTATE_Human1.45236274
23FOXA1_25329375_ChIP-Seq_VCAP_Human1.45236274
24NANOG_19829295_ChIP-Seq_ESCs_Human1.44364138
25SOX2_19829295_ChIP-Seq_ESCs_Human1.44364138
26EWS_26573619_Chip-Seq_HEK293_Human1.41730382
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39561255
28MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38753366
29BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.35502100
30CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.34137500
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.33996800
32AUTS2_25519132_ChIP-Seq_293T-REX_Human1.32747018
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.31286557
34SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31142667
35TAF2_19829295_ChIP-Seq_ESCs_Human1.30175661
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27376850
37GBX2_23144817_ChIP-Seq_PC3_Human1.25835215
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23478558
39CBP_20019798_ChIP-Seq_JUKART_Human1.22450892
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22450892
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.22404595
42GATA3_21878914_ChIP-Seq_MCF-7_Human1.21202783
43GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.21139274
44AR_21572438_ChIP-Seq_LNCaP_Human1.20417339
45BCAT_22108803_ChIP-Seq_LS180_Human1.20245841
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19248916
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18789362
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17502883
49IGF1R_20145208_ChIP-Seq_DFB_Human1.17453807
50IRF1_19129219_ChIP-ChIP_H3396_Human1.17320901
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.16157626
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16083532
53GATA3_21867929_ChIP-Seq_TH1_Mouse1.14344452
54TAL1_26923725_Chip-Seq_HPCs_Mouse1.14275722
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14173398
56ELK1_19687146_ChIP-ChIP_HELA_Human1.13404621
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11866451
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11569484
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11154218
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11136519
61RBPJ_21746931_ChIP-Seq_IB4_Human1.10467107
62SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09582164
63P300_19829295_ChIP-Seq_ESCs_Human1.09181715
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08306046
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07840913
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05447621
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.04975776
68GATA1_26923725_Chip-Seq_HPCs_Mouse1.02100650
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02031278
70NCOR_22424771_ChIP-Seq_293T_Human1.01608683
71EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01303185
72HOXB7_26014856_ChIP-Seq_BT474_Human1.00631094
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99902125
74NANOG_20526341_ChIP-Seq_ESCs_Human0.99081075
75GATA6_21074721_ChIP-Seq_CACO-2_Human0.98822929
76JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98814797
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98506233
78TP53_22573176_ChIP-Seq_HFKS_Human0.98009600
79PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97500344
80FUS_26573619_Chip-Seq_HEK293_Human0.96327314
81GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96108861
82ER_23166858_ChIP-Seq_MCF-7_Human0.94174239
83PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.94098196
84EZH2_27294783_Chip-Seq_ESCs_Mouse0.93531202
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93003196
86SMAD4_21741376_ChIP-Seq_EPCs_Human0.92683717
87KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92374742
88TCF4_22108803_ChIP-Seq_LS180_Human0.92005727
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91581756
90ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91509444
91ETS1_20019798_ChIP-Seq_JURKAT_Human0.90698330
92CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.90376635
93PHF8_20622853_ChIP-Seq_HELA_Human0.89949868
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89699496
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88258685
96SOX2_21211035_ChIP-Seq_LN229_Human0.88134454
97LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87652753
98ETV1_20927104_ChIP-Seq_GIST48_Human0.87595073
99CTCF_20526341_ChIP-Seq_ESCs_Human0.87043871
100GATA3_26560356_Chip-Seq_TH1_Human0.86961210

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002132_abnormal_respiratory_system6.55213602
2MP0006082_CNS_inflammation6.44249385
3MP0001986_abnormal_taste_sensitivity4.17618613
4MP0005408_hypopigmentation3.78964785
5MP0009697_abnormal_copulation3.00507809
6MP0005671_abnormal_response_to2.85895801
7MP0001873_stomach_inflammation2.60935769
8MP0003646_muscle_fatigue2.09693112
9MP0003718_maternal_effect2.09392885
10MP0000858_altered_metastatic_potential2.01446557
11MP0004782_abnormal_surfactant_physiolog1.95714459
12MP0009785_altered_susceptibility_to1.86440888
13MP0005167_abnormal_blood-brain_barrier1.85869954
14MP0005410_abnormal_fertilization1.84402569
15MP0002736_abnormal_nociception_after1.78321737
16MP0002405_respiratory_system_inflammati1.77407272
17MP0005645_abnormal_hypothalamus_physiol1.71412248
18MP0004885_abnormal_endolymph1.67530500
19MP0004142_abnormal_muscle_tone1.67088346
20MP0008872_abnormal_physiological_respon1.67059044
21MP0001835_abnormal_antigen_presentation1.65602270
22MP0001800_abnormal_humoral_immune1.61174937
23MP0001905_abnormal_dopamine_level1.53741608
24MP0009379_abnormal_foot_pigmentation1.50442460
25MP0001968_abnormal_touch/_nociception1.49934960
26MP0005084_abnormal_gallbladder_morpholo1.48390041
27MP0002837_dystrophic_cardiac_calcinosis1.42148187
28MP0005000_abnormal_immune_tolerance1.40000161
29MP0008875_abnormal_xenobiotic_pharmacok1.38195723
30MP0010155_abnormal_intestine_physiology1.36134345
31MP0001485_abnormal_pinna_reflex1.34646774
32MP0010386_abnormal_urinary_bladder1.33096801
33MP0003195_calcinosis1.32154882
34MP0005377_hearing/vestibular/ear_phenot1.30914200
35MP0003878_abnormal_ear_physiology1.30914200
36MP0002163_abnormal_gland_morphology1.29277383
37MP0006292_abnormal_olfactory_placode1.26163578
38MP0005647_abnormal_sex_gland1.23217869
39MP0009764_decreased_sensitivity_to1.20374796
40MP0002184_abnormal_innervation1.20327475
41MP0001727_abnormal_embryo_implantation1.18388218
42MP0004742_abnormal_vestibular_system1.16854339
43MP0008469_abnormal_protein_level1.15785498
44MP0002876_abnormal_thyroid_physiology1.13722312
45MP0001663_abnormal_digestive_system1.13104995
46MP0005083_abnormal_biliary_tract1.10159752
47MP0009333_abnormal_splenocyte_physiolog1.09152272
48MP0002735_abnormal_chemical_nociception1.08090666
49MP0005379_endocrine/exocrine_gland_phen1.07289777
50MP0003315_abnormal_perineum_morphology1.04798829
51MP0008995_early_reproductive_senescence1.03682587
52MP0003252_abnormal_bile_duct1.03634413
53MP0001845_abnormal_inflammatory_respons1.00480802
54MP0008877_abnormal_DNA_methylation1.00193990
55MP0002653_abnormal_ependyma_morphology0.99707059
56MP0003186_abnormal_redox_activity0.99435021
57MP0005389_reproductive_system_phenotype0.97748093
58MP0001919_abnormal_reproductive_system0.96924360
59MP0002723_abnormal_immune_serum0.96743450
60MP0002272_abnormal_nervous_system0.96533512
61MP0008775_abnormal_heart_ventricle0.96354127
62MP0005646_abnormal_pituitary_gland0.95390930
63MP0005367_renal/urinary_system_phenotyp0.95130025
64MP0000516_abnormal_urinary_system0.95130025
65MP0004883_abnormal_blood_vessel0.94403399
66MP0000685_abnormal_immune_system0.94327100
67MP0005551_abnormal_eye_electrophysiolog0.94056792
68MP0005085_abnormal_gallbladder_physiolo0.88214474
69MP0005636_abnormal_mineral_homeostasis0.87195936
70MP0002148_abnormal_hypersensitivity_rea0.85360125
71MP0000230_abnormal_systemic_arterial0.84982549
72MP0002928_abnormal_bile_duct0.84121875
73MP0005025_abnormal_response_to0.83942368
74MP0003786_premature_aging0.82992821
75MP0003638_abnormal_response/metabolism_0.82811498
76MP0005395_other_phenotype0.82215304
77MP0002638_abnormal_pupillary_reflex0.82211129
78MP0008789_abnormal_olfactory_epithelium0.82118144
79MP0009745_abnormal_behavioral_response0.81116325
80MP0005319_abnormal_enzyme/_coenzyme0.79616201
81MP0003011_delayed_dark_adaptation0.77142353
82MP0003119_abnormal_digestive_system0.76292143
83MP0002160_abnormal_reproductive_system0.76040332
84MP0001970_abnormal_pain_threshold0.75821614
85MP0002452_abnormal_antigen_presenting0.75193011
86MP0003045_fibrosis0.71651854
87MP0000467_abnormal_esophagus_morphology0.68676160
88MP0006072_abnormal_retinal_apoptosis0.67775683
89MP0002420_abnormal_adaptive_immunity0.67582312
90MP0002138_abnormal_hepatobiliary_system0.67181426
91MP0003137_abnormal_impulse_conducting0.67063867
92MP0001819_abnormal_immune_cell0.66471450
93MP0000049_abnormal_middle_ear0.66235317
94MP0001853_heart_inflammation0.66159173
95MP0005381_digestive/alimentary_phenotyp0.64935040
96MP0004036_abnormal_muscle_relaxation0.64192451
97MP0005253_abnormal_eye_physiology0.63957055
98MP0003300_gastrointestinal_ulcer0.63804740
99MP0002693_abnormal_pancreas_physiology0.62843665
100MP0002210_abnormal_sex_determination0.60112987

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)7.25096577
2Abnormality of pyrimidine metabolism (HP:0004353)6.37891543
3Zonular cataract (HP:0010920)6.06914739
4Abnormality of the nasal mucosa (HP:0000433)5.87388318
5Elevated erythrocyte sedimentation rate (HP:0003565)4.73222334
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.69537282
7Megaloblastic anemia (HP:0001889)4.20034230
8Degeneration of anterior horn cells (HP:0002398)4.10725926
9Abnormality of the anterior horn cell (HP:0006802)4.10725926
10Abnormality of T cell physiology (HP:0011840)4.01745341
113-Methylglutaconic aciduria (HP:0003535)4.00229119
12Spinal muscular atrophy (HP:0007269)3.72184579
13Macrocytic anemia (HP:0001972)3.60781326
14Delayed CNS myelination (HP:0002188)3.60167482
15Stomach cancer (HP:0012126)3.43560395
16Increased IgM level (HP:0003496)3.37205397
17Thrombocytosis (HP:0001894)3.36682199
18Colon cancer (HP:0003003)3.20897351
19Congenital stationary night blindness (HP:0007642)3.09756457
20Hypsarrhythmia (HP:0002521)3.04453537
21Agitation (HP:0000713)3.01396601
22Diaphragmatic weakness (HP:0009113)2.95957368
23Abnormality of T cells (HP:0002843)2.93103662
24Acute necrotizing encephalopathy (HP:0006965)2.93006506
25Poikilocytosis (HP:0004447)2.88093152
26EEG with generalized epileptiform discharges (HP:0011198)2.86844084
27Epileptiform EEG discharges (HP:0011182)2.77253009
28Myositis (HP:0100614)2.76512306
29Hypoproteinemia (HP:0003075)2.75076730
30Stridor (HP:0010307)2.65552255
31Molar tooth sign on MRI (HP:0002419)2.63932084
32Abnormality of midbrain morphology (HP:0002418)2.63932084
33Nephronophthisis (HP:0000090)2.62796292
34Attenuation of retinal blood vessels (HP:0007843)2.61592496
35Pancreatic cysts (HP:0001737)2.55672145
36Abnormal mitochondria in muscle tissue (HP:0008316)2.54432917
37Gonadotropin excess (HP:0000837)2.52491993
38Reticulocytopenia (HP:0001896)2.51703175
39Abnormality of cells of the erythroid lineage (HP:0012130)2.48609343
40Posterior subcapsular cataract (HP:0007787)2.44407127
41Abnormality of the renal medulla (HP:0100957)2.43178909
42Abnormality of the renal cortex (HP:0011035)2.41529866
43Progressive macrocephaly (HP:0004481)2.40980253
44Stomatitis (HP:0010280)2.38994855
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.38715374
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.38715374
47Pancreatic fibrosis (HP:0100732)2.36425227
48Absent rod-and cone-mediated responses on ERG (HP:0007688)2.32860664
49Fair hair (HP:0002286)2.32206443
50Acute encephalopathy (HP:0006846)2.28461006
51Type 2 muscle fiber atrophy (HP:0003554)2.25846467
52Abnormal rod and cone electroretinograms (HP:0008323)2.25721629
53Synostosis of carpal bones (HP:0005048)2.25684639
54Postaxial foot polydactyly (HP:0001830)2.24580212
55Conjugated hyperbilirubinemia (HP:0002908)2.22712757
56Abnormality of nucleobase metabolism (HP:0010932)2.19295381
57Optic disc pallor (HP:0000543)2.18760452
58Pendular nystagmus (HP:0012043)2.16947595
59Keratoconus (HP:0000563)2.14704387
60Increased corneal curvature (HP:0100692)2.14704387
61Autoimmune thrombocytopenia (HP:0001973)2.14431234
62True hermaphroditism (HP:0010459)2.14365394
63Weak cry (HP:0001612)2.13963915
64Hypochromic anemia (HP:0001931)2.13572653
65Abnormality of B cell number (HP:0010975)2.09638183
66Hemiplegia (HP:0002301)2.08771768
67IgG deficiency (HP:0004315)2.08039530
68Mitochondrial inheritance (HP:0001427)2.07464317
69Vacuolated lymphocytes (HP:0001922)2.07116537
70Decreased electroretinogram (ERG) amplitude (HP:0000654)2.06542228
71Hypergammaglobulinemia (HP:0010702)2.05723152
72Decreased central vision (HP:0007663)2.04833640
73Atrophy/Degeneration involving motor neurons (HP:0007373)2.03689611
74Increased CSF lactate (HP:0002490)1.99894713
75Absent thumb (HP:0009777)1.96531964
76Inability to walk (HP:0002540)1.94308663
77Abnormal number of erythroid precursors (HP:0012131)1.91980915
78Abnormality of T cell number (HP:0011839)1.90766729
79Abolished electroretinogram (ERG) (HP:0000550)1.89536278
80Polyuria (HP:0000103)1.84403641
81Hypochromic microcytic anemia (HP:0004840)1.82117648
82Muscle fiber atrophy (HP:0100295)1.80490856
83Respiratory failure (HP:0002878)1.79218550
84Delayed myelination (HP:0012448)1.78309037
85Asthma (HP:0002099)1.77760811
86Sclerocornea (HP:0000647)1.77730199
87Hepatocellular necrosis (HP:0001404)1.77715279
88Tachypnea (HP:0002789)1.75215068
89Enlarged penis (HP:0000040)1.73738449
90Parakeratosis (HP:0001036)1.71226788
91Tubular atrophy (HP:0000092)1.70126473
92Abnormality of the alveolar ridges (HP:0006477)1.68430078
93Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.66001111
94Degeneration of the lateral corticospinal tracts (HP:0002314)1.66001111
95Abnormality of dental color (HP:0011073)1.64685776
96Erythema (HP:0010783)1.64457607
97Autoimmune hemolytic anemia (HP:0001890)1.63970479
98Conical tooth (HP:0000698)1.63685637
99Interstitial pulmonary disease (HP:0006530)1.63340024
100Renal dysplasia (HP:0000110)1.63119963

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ITK5.03103982
2MAP3K124.58331504
3PTK2B3.62639559
4WNK43.40853343
5ZAP703.22553911
6STK392.82195394
7TXK2.76652912
8MAP4K22.56508833
9INSRR2.18043604
10PINK12.06874883
11MYLK2.06284168
12PRKG21.87599127
13GRK11.73531348
14FRK1.71339565
15ADRBK21.61296351
16NME11.54900769
17GSK3A1.51304204
18TLK11.49986482
19CDK191.49735663
20TBK11.48496740
21PLK41.47271526
22NME21.38719507
23DAPK11.38023244
24KDR1.37247171
25CHEK21.34273813
26PASK1.34194552
27ZAK1.30063727
28WNK31.28347267
29TIE11.20999642
30PAK41.19492034
31OXSR11.18157332
32NUAK11.17601957
33PIK3CA1.17414792
34MAP3K71.16699036
35VRK11.16251727
36SYK1.12719217
37PIM11.10930066
38PIK3CG1.09070913
39MAPK71.05550202
40IKBKB0.97589492
41BTK0.96717771
42CSNK1A10.89789944
43CSNK1A1L0.87719444
44VRK20.80650515
45PLK20.80642581
46TAOK30.79744966
47PDGFRB0.74768772
48MAP4K10.72219400
49ABL20.67994858
50EIF2AK30.66852888
51MAP3K40.64683086
52FLT30.64542215
53FES0.63553338
54PHKG20.62861136
55PHKG10.62861136
56CSNK1G30.62761691
57PRKCQ0.61030486
58CAMK10.57837884
59PRKCZ0.57732800
60ILK0.57295878
61PRKCG0.57203540
62DAPK30.56517442
63MUSK0.55392492
64RPS6KA50.54803992
65CASK0.53305037
66DYRK20.52807014
67PRKCE0.52189453
68OBSCN0.51906785
69GRK70.51745174
70TEC0.50069345
71MAP2K70.50004747
72ERBB30.49581867
73CDK40.49425618
74ADRBK10.49184987
75PRKACA0.48182148
76BMPR20.47558221
77PRKAA20.47533938
78PRKACG0.45550911
79EPHB20.45536339
80GRK60.43198325
81WNK10.42926493
82LYN0.42704803
83PRKCA0.42447799
84PRKG10.42173078
85CSNK1G20.41657910
86BCKDK0.41113726
87PKN10.40517846
88TGFBR20.39862153
89IGF1R0.39660911
90RPS6KA40.39081121
91BMPR1B0.37887607
92CAMK2D0.37856732
93CHUK0.35725646
94MAPKAPK30.35294165
95MINK10.34135397
96CAMK40.33664078
97PLK30.31944776
98MAP3K110.30569489
99ERBB40.30500535
100BCR0.30236447

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.80043872
2Ribosome_Homo sapiens_hsa030103.74507010
3Oxidative phosphorylation_Homo sapiens_hsa001902.97354150
4Drug metabolism - other enzymes_Homo sapiens_hsa009832.85275428
5Allograft rejection_Homo sapiens_hsa053302.62629875
6Autoimmune thyroid disease_Homo sapiens_hsa053202.25009086
7Protein export_Homo sapiens_hsa030602.24897332
8Antigen processing and presentation_Homo sapiens_hsa046122.18477974
9Parkinsons disease_Homo sapiens_hsa050122.17497297
10Type I diabetes mellitus_Homo sapiens_hsa049402.16801030
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.15787285
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.07057863
13Base excision repair_Homo sapiens_hsa034101.99939479
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.94931659
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93936258
16Asthma_Homo sapiens_hsa053101.90542401
17RNA polymerase_Homo sapiens_hsa030201.90013750
18Proteasome_Homo sapiens_hsa030501.88160325
19RNA degradation_Homo sapiens_hsa030181.85039735
20Pyrimidine metabolism_Homo sapiens_hsa002401.83246711
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75468185
22Phototransduction_Homo sapiens_hsa047441.62960045
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60733702
24Huntingtons disease_Homo sapiens_hsa050161.56481092
25Primary immunodeficiency_Homo sapiens_hsa053401.51670340
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.51265152
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.50449658
28Cardiac muscle contraction_Homo sapiens_hsa042601.47878012
29Alzheimers disease_Homo sapiens_hsa050101.45076402
30Rheumatoid arthritis_Homo sapiens_hsa053231.42816667
31Arginine biosynthesis_Homo sapiens_hsa002201.29246355
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26532146
33Homologous recombination_Homo sapiens_hsa034401.24306425
34Viral myocarditis_Homo sapiens_hsa054161.20508938
35Linoleic acid metabolism_Homo sapiens_hsa005911.19696033
36Malaria_Homo sapiens_hsa051441.18800021
37Caffeine metabolism_Homo sapiens_hsa002321.15511438
38Basal transcription factors_Homo sapiens_hsa030221.14634925
39Hematopoietic cell lineage_Homo sapiens_hsa046401.12171195
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09616496
41T cell receptor signaling pathway_Homo sapiens_hsa046601.09416675
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.07423654
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.04640084
44Staphylococcus aureus infection_Homo sapiens_hsa051501.02564750
45Chemical carcinogenesis_Homo sapiens_hsa052041.01166589
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00827747
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98300359
48RNA transport_Homo sapiens_hsa030130.96018836
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91226614
50Olfactory transduction_Homo sapiens_hsa047400.90971659
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.88861050
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88454482
53Nitrogen metabolism_Homo sapiens_hsa009100.85955518
54Fanconi anemia pathway_Homo sapiens_hsa034600.84910165
55African trypanosomiasis_Homo sapiens_hsa051430.83425406
56Retinol metabolism_Homo sapiens_hsa008300.82127916
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78600925
58Spliceosome_Homo sapiens_hsa030400.76856341
59Mismatch repair_Homo sapiens_hsa034300.75820793
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72680794
61DNA replication_Homo sapiens_hsa030300.72619232
62Butanoate metabolism_Homo sapiens_hsa006500.72265470
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71031281
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70219498
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.69186820
66beta-Alanine metabolism_Homo sapiens_hsa004100.68403892
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67175662
68Peroxisome_Homo sapiens_hsa041460.65747077
69Purine metabolism_Homo sapiens_hsa002300.62625248
70Tryptophan metabolism_Homo sapiens_hsa003800.61683450
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59361549
72Nicotine addiction_Homo sapiens_hsa050330.59171848
73Ovarian steroidogenesis_Homo sapiens_hsa049130.57892009
74Nucleotide excision repair_Homo sapiens_hsa034200.57358809
75Systemic lupus erythematosus_Homo sapiens_hsa053220.56522731
76Vitamin B6 metabolism_Homo sapiens_hsa007500.54042190
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52833093
78Insulin secretion_Homo sapiens_hsa049110.52351253
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50665529
80Taste transduction_Homo sapiens_hsa047420.50012800
81Selenocompound metabolism_Homo sapiens_hsa004500.48108528
82Sulfur metabolism_Homo sapiens_hsa009200.45822195
83Fat digestion and absorption_Homo sapiens_hsa049750.41252957
84Metabolic pathways_Homo sapiens_hsa011000.40592280
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38998881
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38129460
87Leishmaniasis_Homo sapiens_hsa051400.37450242
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34176569
89Morphine addiction_Homo sapiens_hsa050320.33575556
90Arginine and proline metabolism_Homo sapiens_hsa003300.32432708
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29779519
92Arachidonic acid metabolism_Homo sapiens_hsa005900.29730342
93Regulation of autophagy_Homo sapiens_hsa041400.28561103
94Glycerolipid metabolism_Homo sapiens_hsa005610.24292666
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23774770
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.23287881
97Collecting duct acid secretion_Homo sapiens_hsa049660.23072606
98Synaptic vesicle cycle_Homo sapiens_hsa047210.22584700
99Measles_Homo sapiens_hsa051620.21743372
100One carbon pool by folate_Homo sapiens_hsa006700.20243146

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