ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	7.59238311
2	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	6.69684930
3	regulation of isotype switching to IgG isotypes (GO:0048302)	5.99747238
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.13262692
5	ATP synthesis coupled proton transport (GO:0015986)	5.13262692
6	regulation of immunoglobulin secretion (GO:0051023)	4.99232928
7	negative regulation of B cell apoptotic process (GO:0002903)	4.82424313
8	chaperone-mediated protein transport (GO:0072321)	4.78740216
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.64816177
10	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.58162140
11	regulation of regulatory T cell differentiation (GO:0045589)	4.55371516
12	protein neddylation (GO:0045116)	4.34012012
13	positive regulation of interleukin-17 production (GO:0032740)	4.33334161
14	GTP biosynthetic process (GO:0006183)	4.32502592
15	behavioral response to nicotine (GO:0035095)	4.16700685
16	kinetochore assembly (GO:0051382)	4.02859611
17	positive regulation of isotype switching (GO:0045830)	3.99256683
18	inner mitochondrial membrane organization (GO:0007007)	3.87336134
19	DNA deamination (GO:0045006)	3.74836583
20	positive regulation of DNA recombination (GO:0045911)	3.74729595
21	interferon-gamma production (GO:0032609)	3.71899249
22	kinetochore organization (GO:0051383)	3.68608261
23	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.62259806
24	piRNA metabolic process (GO:0034587)	3.52613930
25	positive regulation of activated T cell proliferation (GO:0042104)	3.49492793
26	UTP biosynthetic process (GO:0006228)	3.48381622
27	protein localization to cilium (GO:0061512)	3.41101539
28	DNA double-strand break processing (GO:0000729)	3.38493672
29	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.35006348
30	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.32656428
31	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.31298099
32	UTP metabolic process (GO:0046051)	3.29375757
33	regulation of B cell apoptotic process (GO:0002902)	3.28046185
34	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.26221895
35	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.26184631
36	viral protein processing (GO:0019082)	3.19385140
37	regulation of action potential (GO:0098900)	3.19010274
38	electron transport chain (GO:0022900)	3.18636364
39	respiratory electron transport chain (GO:0022904)	3.17056958
40	hydrogen ion transmembrane transport (GO:1902600)	3.14551486
41	protein complex biogenesis (GO:0070271)	3.10647156
42	negative regulation of telomere maintenance (GO:0032205)	3.09469060
43	positive regulation of immunoglobulin production (GO:0002639)	3.09326868
44	DNA methylation involved in gamete generation (GO:0043046)	3.08475432
45	meiotic chromosome segregation (GO:0045132)	3.06455358
46	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.00559642
47	NADH dehydrogenase complex assembly (GO:0010257)	3.00559642
48	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.00559642
49	ATP biosynthetic process (GO:0006754)	2.99338786
50	maturation of SSU-rRNA (GO:0030490)	2.98590697
51	base-excision repair, AP site formation (GO:0006285)	2.97799702
52	proton transport (GO:0015992)	2.92833364
53	preassembly of GPI anchor in ER membrane (GO:0016254)	2.92299829
54	cell wall macromolecule catabolic process (GO:0016998)	2.88095874
55	response to pheromone (GO:0019236)	2.85783613
56	positive regulation of mitochondrial fission (GO:0090141)	2.84451708
57	mitochondrial respiratory chain complex assembly (GO:0033108)	2.82853332
58	hydrogen transport (GO:0006818)	2.82272038
59	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.81501128
60	CTP metabolic process (GO:0046036)	2.80421939
61	CTP biosynthetic process (GO:0006241)	2.80421939
62	cellular response to exogenous dsRNA (GO:0071360)	2.80195854
63	positive regulation of dendritic spine development (GO:0060999)	2.79846400
64	tRNA processing (GO:0008033)	2.77140335
65	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.76446014
66	proteasome assembly (GO:0043248)	2.76210950
67	respiratory chain complex IV assembly (GO:0008535)	2.71916625
68	protein insertion into membrane (GO:0051205)	2.69894063
69	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.63351912
70	inositol phosphate dephosphorylation (GO:0046855)	2.63351912
71	positive regulation of B cell mediated immunity (GO:0002714)	2.60614454
72	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.60614454
73	regulation of activated T cell proliferation (GO:0046006)	2.59557506
74	rRNA modification (GO:0000154)	2.58759977
75	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.55590798
76	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.55590798
77	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.55548192
78	DNA dealkylation (GO:0035510)	2.55443460
79	platelet dense granule organization (GO:0060155)	2.55425091
80	intracellular protein transmembrane import (GO:0044743)	2.54868562
81	L-fucose catabolic process (GO:0042355)	2.54614265
82	fucose catabolic process (GO:0019317)	2.54614265
83	L-fucose metabolic process (GO:0042354)	2.54614265
84	protein peptidyl-prolyl isomerization (GO:0000413)	2.53286090
85	positive regulation of defense response to virus by host (GO:0002230)	2.52816064
86	positive regulation of fatty acid transport (GO:2000193)	2.52661517
87	rRNA methylation (GO:0031167)	2.52206566
88	protein K6-linked ubiquitination (GO:0085020)	2.51507421
89	resolution of meiotic recombination intermediates (GO:0000712)	2.51465734
90	nucleoside diphosphate phosphorylation (GO:0006165)	2.49531532
91	inositol phosphate catabolic process (GO:0071545)	2.47344909
92	positive regulation of prostaglandin secretion (GO:0032308)	2.45306903
93	C-terminal protein lipidation (GO:0006501)	2.45020666
94	water-soluble vitamin biosynthetic process (GO:0042364)	2.44913965
95	regulation of podosome assembly (GO:0071801)	2.44867062
96	polyol catabolic process (GO:0046174)	2.42705169
97	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.42082904
98	termination of RNA polymerase III transcription (GO:0006386)	2.41987511
99	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.41987511
100	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.41473349

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.25422837
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.83524237
3	VDR_22108803_ChIP-Seq_LS180_Human	3.62525348
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.55666024
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.33423783
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.15441933
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.98225946
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.81447217
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.53680635
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.37556779
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.12622704
12	MYC_18940864_ChIP-ChIP_HL60_Human	2.06155206
13	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.03686756
14	IRF1_19129219_ChIP-ChIP_H3396_Human	1.93573593
15	EWS_26573619_Chip-Seq_HEK293_Human	1.87985538
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.87727278
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.85427239
18	FOXP3_21729870_ChIP-Seq_TREG_Human	1.83418082
19	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.81799366
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.80516573
21	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.79019380
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.75082882
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.71847250
24	FUS_26573619_Chip-Seq_HEK293_Human	1.68618661
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.68045839
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.66327258
27	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.63041149
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.62625351
29	SOX2_19829295_ChIP-Seq_ESCs_Human	1.62141023
30	NANOG_19829295_ChIP-Seq_ESCs_Human	1.62141023
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.61211347
32	IGF1R_20145208_ChIP-Seq_DFB_Human	1.59856380
33	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.57320472
34	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.56676294
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.56454560
36	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.56422625
37	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.56304189
38	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.55682681
39	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.55326506
40	P300_19829295_ChIP-Seq_ESCs_Human	1.52477800
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.51283650
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.51283650
43	TP53_22573176_ChIP-Seq_HFKS_Human	1.45122429
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.40985942
45	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.38766402
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.37450230
47	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.33504049
48	BCAT_22108803_ChIP-Seq_LS180_Human	1.32313433
49	EZH2_22144423_ChIP-Seq_EOC_Human	1.32267647
50	GBX2_23144817_ChIP-Seq_PC3_Human	1.31297200
51	NANOG_20526341_ChIP-Seq_ESCs_Human	1.30433918
52	NCOR_22424771_ChIP-Seq_293T_Human	1.29033893
53	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.29023049
54	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.28692919
55	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.26356690
56	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.23137213
57	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.22205820
58	TTF2_22483619_ChIP-Seq_HELA_Human	1.20877702
59	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.19726047
60	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.18885583
61	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.17746620
62	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.17454130
63	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.15637900
64	TAF15_26573619_Chip-Seq_HEK293_Human	1.15062834
65	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.12475099
66	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12187326
67	TAF2_19829295_ChIP-Seq_ESCs_Human	1.10500375
68	MYC_19829295_ChIP-Seq_ESCs_Human	1.09707932
69	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.08627944
70	HTT_18923047_ChIP-ChIP_STHdh_Human	1.08152715
71	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08091365
72	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.08001792
73	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.06825034
74	CBP_20019798_ChIP-Seq_JUKART_Human	1.04298221
75	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.04298221
76	GABP_19822575_ChIP-Seq_HepG2_Human	1.03924479
77	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02077356
78	RNF2_27304074_Chip-Seq_NSC_Mouse	1.01953406
79	TCF4_22108803_ChIP-Seq_LS180_Human	1.00972617
80	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.97968285
81	GATA3_26560356_Chip-Seq_TH2_Human	0.97951740
82	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97419258
83	ERA_21632823_ChIP-Seq_H3396_Human	0.97268400
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.96048681
85	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.94796238
86	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.93942380
87	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.93880495
88	AR_20517297_ChIP-Seq_VCAP_Human	0.92884565
89	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.92785806
90	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.92446523
91	REST_21632747_ChIP-Seq_MESCs_Mouse	0.92147694
92	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.90743923
93	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.89777722
94	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.89591302
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.88929795
96	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.88090161
97	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.87845318
98	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.86478888
99	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.85787828
100	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.85539429

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.54979045
2	MP0003786_premature_aging	2.91853141
3	MP0002138_abnormal_hepatobiliary_system	2.81580343
4	MP0005645_abnormal_hypothalamus_physiol	2.60136744
5	MP0003195_calcinosis	2.57874998
6	MP0008872_abnormal_physiological_respon	2.55034563
7	MP0001835_abnormal_antigen_presentation	2.49204152
8	MP0008995_early_reproductive_senescence	2.46676705
9	MP0005389_reproductive_system_phenotype	2.36629176
10	MP0008875_abnormal_xenobiotic_pharmacok	2.25910495
11	MP0002837_dystrophic_cardiac_calcinosis	2.22367238
12	MP0002160_abnormal_reproductive_system	2.21084056
13	MP0003646_muscle_fatigue	2.17125994
14	MP0008877_abnormal_DNA_methylation	2.11571168
15	MP0003300_gastrointestinal_ulcer	2.11407704
16	MP0002139_abnormal_hepatobiliary_system	2.08356113
17	MP0004147_increased_porphyrin_level	2.02595749
18	MP0006276_abnormal_autonomic_nervous	1.93963868
19	MP0000604_amyloidosis	1.93144530
20	MP0001919_abnormal_reproductive_system	1.87398617
21	MP0002102_abnormal_ear_morphology	1.86522434
22	MP0004142_abnormal_muscle_tone	1.81894268
23	MP0005551_abnormal_eye_electrophysiolog	1.80515056
24	MP0006072_abnormal_retinal_apoptosis	1.74843144
25	MP0004145_abnormal_muscle_electrophysio	1.69170158
26	MP0001986_abnormal_taste_sensitivity	1.66864573
27	MP0002876_abnormal_thyroid_physiology	1.64165471
28	MP0002234_abnormal_pharynx_morphology	1.61009128
29	MP0005084_abnormal_gallbladder_morpholo	1.59558221
30	MP0003283_abnormal_digestive_organ	1.56065121
31	MP0001853_heart_inflammation	1.49601163
32	MP0003880_abnormal_central_pattern	1.45191246
33	MP0005360_urolithiasis	1.44327409
34	MP0009046_muscle_twitch	1.43935469
35	MP0002272_abnormal_nervous_system	1.43913856
36	MP0009745_abnormal_behavioral_response	1.39541876
37	MP0002163_abnormal_gland_morphology	1.39049748
38	MP0000465_gastrointestinal_hemorrhage	1.38211352
39	MP0004043_abnormal_pH_regulation	1.37311939
40	MP0005410_abnormal_fertilization	1.35001813
41	MP0008058_abnormal_DNA_repair	1.33102823
42	MP0003122_maternal_imprinting	1.32616693
43	MP0000372_irregular_coat_pigmentation	1.30563636
44	MP0005671_abnormal_response_to	1.29779375
45	MP0004742_abnormal_vestibular_system	1.26097570
46	MP0001293_anophthalmia	1.25641309
47	MP0004133_heterotaxia	1.24627162
48	MP0001502_abnormal_circadian_rhythm	1.23605085
49	MP0005253_abnormal_eye_physiology	1.18977986
50	MP0005167_abnormal_blood-brain_barrier	1.18936889
51	MP0003718_maternal_effect	1.18311828
52	MP0005085_abnormal_gallbladder_physiolo	1.18131557
53	MP0001968_abnormal_touch/_nociception	1.16852590
54	MP0005646_abnormal_pituitary_gland	1.12486784
55	MP0001501_abnormal_sleep_pattern	1.11391230
56	MP0002938_white_spotting	1.11149928
57	MP0000427_abnormal_hair_cycle	1.08622317
58	MP0005423_abnormal_somatic_nervous	1.07815631
59	MP0004885_abnormal_endolymph	1.04791535
60	MP0005365_abnormal_bile_salt	1.03299181
61	MP0002733_abnormal_thermal_nociception	1.02329757
62	MP0002277_abnormal_respiratory_mucosa	1.01621398
63	MP0001873_stomach_inflammation	1.01247690
64	MP0001970_abnormal_pain_threshold	1.01117841
65	MP0002693_abnormal_pancreas_physiology	0.97487643
66	MP0002928_abnormal_bile_duct	0.95428842
67	MP0001929_abnormal_gametogenesis	0.95195421
68	MP0001440_abnormal_grooming_behavior	0.95162265
69	MP0006035_abnormal_mitochondrial_morpho	0.93545995
70	MP0002210_abnormal_sex_determination	0.93454902
71	MP0001800_abnormal_humoral_immune	0.89263594
72	MP0003186_abnormal_redox_activity	0.88782242
73	MP0002638_abnormal_pupillary_reflex	0.86821805
74	MP0002557_abnormal_social/conspecific_i	0.86784398
75	MP0000631_abnormal_neuroendocrine_gland	0.85352514
76	MP0006036_abnormal_mitochondrial_physio	0.81824554
77	MP0002822_catalepsy	0.80124892
78	MP0003724_increased_susceptibility_to	0.79997758
79	MP0000685_abnormal_immune_system	0.79203080
80	MP0000653_abnormal_sex_gland	0.77941365
81	MP0003121_genomic_imprinting	0.76957961
82	MP0002064_seizures	0.76712186
83	MP0002736_abnormal_nociception_after	0.76439905
84	MP0002572_abnormal_emotion/affect_behav	0.73972449
85	MP0001790_abnormal_immune_system	0.73945135
86	MP0005387_immune_system_phenotype	0.73945135
87	MP0005195_abnormal_posterior_eye	0.73514666
88	MP0003698_abnormal_male_reproductive	0.73208276
89	MP0005377_hearing/vestibular/ear_phenot	0.72997267
90	MP0003878_abnormal_ear_physiology	0.72997267
91	MP0000647_abnormal_sebaceous_gland	0.71356910
92	MP0002653_abnormal_ependyma_morphology	0.71266946
93	MP0001145_abnormal_male_reproductive	0.70791624
94	MP0001348_abnormal_lacrimal_gland	0.70158399
95	MP0005636_abnormal_mineral_homeostasis	0.70014300
96	MP0008775_abnormal_heart_ventricle	0.69693653
97	MP0008961_abnormal_basal_metabolism	0.69671515
98	MP0002148_abnormal_hypersensitivity_rea	0.69403459
99	MP0002229_neurodegeneration	0.68719035
100	MP0003252_abnormal_bile_duct	0.68490370

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	5.26714799
2	Molar tooth sign on MRI (HP:0002419)	3.98154490
3	Abnormality of midbrain morphology (HP:0002418)	3.98154490
4	Pancreatic cysts (HP:0001737)	3.44630459
5	Mitochondrial inheritance (HP:0001427)	3.33526725
6	True hermaphroditism (HP:0010459)	3.27384263
7	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.26548374
8	Acute encephalopathy (HP:0006846)	3.22956832
9	Nephronophthisis (HP:0000090)	3.19896665
10	Acute necrotizing encephalopathy (HP:0006965)	3.18799691
11	Pancreatic fibrosis (HP:0100732)	3.16784043
12	Increased CSF lactate (HP:0002490)	3.10769130
13	Pendular nystagmus (HP:0012043)	3.07697780
14	Congenital stationary night blindness (HP:0007642)	3.06132033
15	Constricted visual fields (HP:0001133)	3.03039846
16	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.99526473
17	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.99526473
18	Abnormal mitochondria in muscle tissue (HP:0008316)	2.91738881
19	Optic disc pallor (HP:0000543)	2.89995856
20	Hepatocellular necrosis (HP:0001404)	2.84284599
21	Attenuation of retinal blood vessels (HP:0007843)	2.80542177
22	Abolished electroretinogram (ERG) (HP:0000550)	2.79132282
23	Abnormality of the pons (HP:0007361)	2.74425724
24	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.67741808
25	Colon cancer (HP:0003003)	2.63577587
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.63426907
27	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.61669914
28	Increased serum lactate (HP:0002151)	2.61536163
29	Large for gestational age (HP:0001520)	2.58399752
30	Increased hepatocellular lipid droplets (HP:0006565)	2.57830088
31	Progressive macrocephaly (HP:0004481)	2.55063450
32	Lipid accumulation in hepatocytes (HP:0006561)	2.54252261
33	Stomatitis (HP:0010280)	2.51802293
34	Absent/shortened dynein arms (HP:0200106)	2.47206843
35	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.47206843
36	Abnormality of the renal medulla (HP:0100957)	2.44872500
37	Broad-based gait (HP:0002136)	2.43196894
38	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.40584341
39	Elevated erythrocyte sedimentation rate (HP:0003565)	2.38699391
40	Hepatic necrosis (HP:0002605)	2.33485736
41	Sclerocornea (HP:0000647)	2.33255570
42	Panhypogammaglobulinemia (HP:0003139)	2.32404848
43	Congenital, generalized hypertrichosis (HP:0004540)	2.31999679
44	Lactic acidosis (HP:0003128)	2.30174074
45	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.27519946
46	Duplicated collecting system (HP:0000081)	2.23801889
47	Cystic liver disease (HP:0006706)	2.20720831
48	Hypothermia (HP:0002045)	2.20091922
49	Entropion (HP:0000621)	2.17955716
50	Bony spicule pigmentary retinopathy (HP:0007737)	2.15937011
51	Abnormality of the renal collecting system (HP:0004742)	2.15768776
52	Abnormal respiratory epithelium morphology (HP:0012253)	2.13223907
53	Abnormal respiratory motile cilium morphology (HP:0005938)	2.13223907
54	Abnormality of cells of the erythroid lineage (HP:0012130)	2.11836136
55	Tetany (HP:0001281)	2.10803581
56	Medial flaring of the eyebrow (HP:0010747)	2.09823055
57	Male pseudohermaphroditism (HP:0000037)	2.09643201
58	Hypoplasia of the pons (HP:0012110)	2.08714198
59	Rib fusion (HP:0000902)	2.08646230
60	Hyperalaninemia (HP:0003348)	2.05110878
61	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.05110878
62	Abnormality of alanine metabolism (HP:0010916)	2.05110878
63	Abnormal biliary tract physiology (HP:0012439)	2.04048494
64	Bile duct proliferation (HP:0001408)	2.04048494
65	Abnormality of the anterior horn cell (HP:0006802)	2.03857416
66	Degeneration of anterior horn cells (HP:0002398)	2.03857416
67	Anencephaly (HP:0002323)	2.00822667
68	Reticulocytopenia (HP:0001896)	2.00705189
69	Absent thumb (HP:0009777)	2.00498362
70	Abnormality of renal resorption (HP:0011038)	1.98020612
71	Polyphagia (HP:0002591)	1.97430948
72	Hyperglycinemia (HP:0002154)	1.96616949
73	Hypomagnesemia (HP:0002917)	1.95551025
74	Agitation (HP:0000713)	1.95528143
75	Adrenal hypoplasia (HP:0000835)	1.94899811
76	Abnormal number of erythroid precursors (HP:0012131)	1.94368493
77	Abnormal ciliary motility (HP:0012262)	1.94220743
78	Decreased central vision (HP:0007663)	1.92838403
79	IgG deficiency (HP:0004315)	1.91940411
80	Congenital hepatic fibrosis (HP:0002612)	1.90641863
81	Submucous cleft hard palate (HP:0000176)	1.90011589
82	Chronic hepatic failure (HP:0100626)	1.86585493
83	Exertional dyspnea (HP:0002875)	1.83940661
84	Rhinitis (HP:0012384)	1.82485035
85	Azoospermia (HP:0000027)	1.81140644
86	Increased intramyocellular lipid droplets (HP:0012240)	1.80147399
87	Narrow forehead (HP:0000341)	1.79788313
88	Focal motor seizures (HP:0011153)	1.79689215
89	Renal Fanconi syndrome (HP:0001994)	1.78878425
90	Abnormality of the labia minora (HP:0012880)	1.78555333
91	Abnormality of the prostate (HP:0008775)	1.78483997
92	Severe combined immunodeficiency (HP:0004430)	1.77064664
93	Aplasia/hypoplasia of the uterus (HP:0008684)	1.76657909
94	Abnormal respiratory motile cilium physiology (HP:0012261)	1.75578491
95	Abnormality of DNA repair (HP:0003254)	1.75327060
96	Hypoplasia of the uterus (HP:0000013)	1.75309694
97	Type II lissencephaly (HP:0007260)	1.72480471
98	Respiratory failure (HP:0002878)	1.71548259
99	Hypoproteinemia (HP:0003075)	1.70776800
100	Exercise intolerance (HP:0003546)	1.70207082

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NUAK1	3.39158460
2	NEK1	3.28763467
3	TAOK3	3.20381668
4	WNK3	2.91358376
5	BUB1	2.90503610
6	ZAK	2.69668487
7	ADRBK2	2.61765943
8	STK16	2.43981263
9	GRK1	2.37860949
10	MUSK	2.27470794
11	TLK1	2.15653461
12	MAP4K2	2.03449049
13	TNIK	1.96986141
14	VRK2	1.96585767
15	PINK1	1.89431033
16	WNK4	1.85266903
17	NEK2	1.77586435
18	TEC	1.64881449
19	FRK	1.50623440
20	PHKG1	1.50133659
21	PHKG2	1.50133659
22	TSSK6	1.49992653
23	EPHA4	1.46549927
24	VRK1	1.46481654
25	BMPR1B	1.46010210
26	EIF2AK3	1.40503133
27	MAPK13	1.38933875
28	CDK19	1.19151813
29	FES	1.10984669
30	MST4	1.09892330
31	EIF2AK1	1.05725098
32	GRK6	1.05285183
33	PLK2	1.04222696
34	PIK3CA	1.00495027
35	PLK3	0.97829806
36	NTRK1	0.96872631
37	TXK	0.96599217
38	UHMK1	0.95608255
39	ITK	0.94531101
40	FLT3	0.90395231
41	DAPK2	0.89218939
42	SIK2	0.88808654
43	BCKDK	0.87562982
44	STK39	0.86304492
45	OXSR1	0.85361545
46	IKBKB	0.85356848
47	TRIM28	0.81602040
48	PLK4	0.80350474
49	MAP4K1	0.78972230
50	GRK5	0.78337256
51	PRKD3	0.77572349
52	MAP2K2	0.74220175
53	MAP2K7	0.71405075
54	PRKCE	0.70855427
55	MAP3K4	0.68067060
56	CSNK1G2	0.66616493
57	EPHB2	0.66392799
58	CASK	0.66165846
59	STK3	0.65768632
60	MAP2K6	0.65706529
61	CSNK1A1L	0.63705501
62	KIT	0.61811849
63	INSRR	0.60929730
64	BRSK1	0.59902992
65	ADRBK1	0.59225216
66	PRKCQ	0.59071790
67	PBK	0.58851622
68	PRKD2	0.56289457
69	MARK1	0.56064323
70	MAP3K14	0.54737934
71	ATR	0.53820176
72	AURKA	0.53675780
73	EIF2AK2	0.53026790
74	SYK	0.52506002
75	BTK	0.52233975
76	LMTK2	0.51607095
77	CSNK1G3	0.51299663
78	PLK1	0.50578179
79	DYRK2	0.46700863
80	STK38L	0.45389556
81	CSF1R	0.42616096
82	DAPK3	0.41221620
83	ACVR1B	0.39805443
84	MAP3K11	0.39455831
85	PRKCH	0.39154347
86	PRKCG	0.37284011
87	NME1	0.36675167
88	TGFBR1	0.36644749
89	NEK9	0.36512262
90	NME2	0.36332705
91	CSNK2A2	0.35536557
92	PRKACA	0.35384597
93	ATM	0.34896205
94	CAMKK2	0.34433832
95	PRKCA	0.34063139
96	ILK	0.33037040
97	CDK3	0.32870635
98	BRSK2	0.31719661
99	TIE1	0.31299447
100	CSNK1E	0.30673238

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.23566319
2	Allograft rejection_Homo sapiens_hsa05330	3.51576042
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.36571277
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.35132340
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.17818275
6	Parkinsons disease_Homo sapiens_hsa05012	2.75582825
7	Type I diabetes mellitus_Homo sapiens_hsa04940	2.62726508
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.52757015
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.52552746
10	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.26923205
11	Proteasome_Homo sapiens_hsa03050	2.24493828
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.06242206
13	Basal transcription factors_Homo sapiens_hsa03022	2.03830945
14	Alzheimers disease_Homo sapiens_hsa05010	1.95535215
15	Huntingtons disease_Homo sapiens_hsa05016	1.78835990
16	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.78498068
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.76628901
18	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.72492005
19	Phototransduction_Homo sapiens_hsa04744	1.70869447
20	RNA polymerase_Homo sapiens_hsa03020	1.66162756
21	Ribosome_Homo sapiens_hsa03010	1.65560504
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.63160143
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.60758011
24	Protein export_Homo sapiens_hsa03060	1.59919357
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.51771697
26	RNA degradation_Homo sapiens_hsa03018	1.51165955
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.47662500
28	Sulfur relay system_Homo sapiens_hsa04122	1.33637521
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.33404482
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.25922185
31	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.23038716
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.21350526
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.18656009
34	Peroxisome_Homo sapiens_hsa04146	1.18147040
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.11988950
36	Primary immunodeficiency_Homo sapiens_hsa05340	1.10912227
37	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.07533454
38	Rheumatoid arthritis_Homo sapiens_hsa05323	1.02916786
39	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.02722037
40	Nicotine addiction_Homo sapiens_hsa05033	1.01663222
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.99747747
42	Nitrogen metabolism_Homo sapiens_hsa00910	0.96067356
43	Spliceosome_Homo sapiens_hsa03040	0.95996794
44	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.94417852
45	Fat digestion and absorption_Homo sapiens_hsa04975	0.93965630
46	Homologous recombination_Homo sapiens_hsa03440	0.86961505
47	Collecting duct acid secretion_Homo sapiens_hsa04966	0.85633217
48	Pyrimidine metabolism_Homo sapiens_hsa00240	0.83916971
49	Caffeine metabolism_Homo sapiens_hsa00232	0.83778831
50	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.79138045
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.78223546
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.76806130
53	Mineral absorption_Homo sapiens_hsa04978	0.76408078
54	Antigen processing and presentation_Homo sapiens_hsa04612	0.75958102
55	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.75299815
56	Propanoate metabolism_Homo sapiens_hsa00640	0.73829141
57	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.69267385
58	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.67832775
59	Mismatch repair_Homo sapiens_hsa03430	0.67371054
60	Butanoate metabolism_Homo sapiens_hsa00650	0.66924910
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66647950
62	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.66456453
63	p53 signaling pathway_Homo sapiens_hsa04115	0.64904733
64	Nucleotide excision repair_Homo sapiens_hsa03420	0.64764991
65	Olfactory transduction_Homo sapiens_hsa04740	0.64067938
66	Sulfur metabolism_Homo sapiens_hsa00920	0.59319796
67	Insulin secretion_Homo sapiens_hsa04911	0.58857111
68	Metabolic pathways_Homo sapiens_hsa01100	0.58764373
69	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.57886146
70	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.57494897
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.56167152
72	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.56026482
73	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.54891157
74	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.52866922
75	RNA transport_Homo sapiens_hsa03013	0.50621735
76	Folate biosynthesis_Homo sapiens_hsa00790	0.47761651
77	Fatty acid elongation_Homo sapiens_hsa00062	0.45461689
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44235399
79	One carbon pool by folate_Homo sapiens_hsa00670	0.42724322
80	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42578337
81	Retinol metabolism_Homo sapiens_hsa00830	0.41111347
82	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.40864205
83	Purine metabolism_Homo sapiens_hsa00230	0.40013734
84	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.39593607
85	Regulation of autophagy_Homo sapiens_hsa04140	0.39176848
86	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.37865523
87	Taste transduction_Homo sapiens_hsa04742	0.37266288
88	Selenocompound metabolism_Homo sapiens_hsa00450	0.36023946
89	Tryptophan metabolism_Homo sapiens_hsa00380	0.34584680
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.34308807
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.33952509
92	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.33829551
93	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.30684299
94	Circadian rhythm_Homo sapiens_hsa04710	0.30437668
95	Morphine addiction_Homo sapiens_hsa05032	0.29875706
96	Base excision repair_Homo sapiens_hsa03410	0.26521118
97	Glutathione metabolism_Homo sapiens_hsa00480	0.25671888
98	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.25077997
99	Viral myocarditis_Homo sapiens_hsa05416	0.22897689
100	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.22370038

UBA52P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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