ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of B cell apoptotic process (GO:0002903)	5.96982374
2	behavioral response to nicotine (GO:0035095)	5.95813782
3	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	5.88397811
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.59027364
5	ATP synthesis coupled proton transport (GO:0015986)	5.59027364
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.49781426
7	DNA deamination (GO:0045006)	5.15189072
8	regulation of immunoglobulin secretion (GO:0051023)	4.95196735
9	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.86258102
10	regulation of regulatory T cell differentiation (GO:0045589)	4.60877005
11	sequestering of actin monomers (GO:0042989)	4.40408641
12	regulation of isotype switching to IgG isotypes (GO:0048302)	4.35438294
13	regulation of B cell apoptotic process (GO:0002902)	4.06371942
14	ribosomal small subunit assembly (GO:0000028)	3.95174266
15	positive regulation of prostaglandin secretion (GO:0032308)	3.56124263
16	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.51350977
17	protein neddylation (GO:0045116)	3.50214823
18	pseudouridine synthesis (GO:0001522)	3.48625468
19	peptidyl-histidine modification (GO:0018202)	3.44503077
20	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.38472953
21	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.38472953
22	NIK/NF-kappaB signaling (GO:0038061)	3.34796892
23	respiratory electron transport chain (GO:0022904)	3.33703504
24	electron transport chain (GO:0022900)	3.33087551
25	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.27843999
26	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.27843999
27	isotype switching (GO:0045190)	3.27843999
28	cytidine catabolic process (GO:0006216)	3.26899238
29	cytidine deamination (GO:0009972)	3.26899238
30	cytidine metabolic process (GO:0046087)	3.26899238
31	protein complex biogenesis (GO:0070271)	3.24902859
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.23631895
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.23631895
34	NADH dehydrogenase complex assembly (GO:0010257)	3.23631895
35	regulation of memory T cell differentiation (GO:0043380)	3.21853489
36	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	3.17497649
37	myoblast migration (GO:0051451)	3.13067078
38	positive regulation of interleukin-17 production (GO:0032740)	3.13066792
39	regulation of prostaglandin secretion (GO:0032306)	3.11305633
40	negative regulation of telomere maintenance (GO:0032205)	3.07740460
41	ATP biosynthetic process (GO:0006754)	3.04696070
42	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.04485262
43	regulation of T cell mediated cytotoxicity (GO:0001914)	3.01994374
44	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.99859845
45	L-fucose catabolic process (GO:0042355)	2.95111027
46	fucose catabolic process (GO:0019317)	2.95111027
47	L-fucose metabolic process (GO:0042354)	2.95111027
48	negative regulation of mast cell activation (GO:0033004)	2.93624335
49	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.93232987
50	interferon-gamma production (GO:0032609)	2.91916606
51	embryonic hemopoiesis (GO:0035162)	2.90222448
52	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.85365519
53	mitochondrial respiratory chain complex assembly (GO:0033108)	2.85252340
54	GTP biosynthetic process (GO:0006183)	2.84545132
55	positive regulation of immune response to tumor cell (GO:0002839)	2.84164557
56	regulation of immune response to tumor cell (GO:0002837)	2.84164557
57	regulation of response to tumor cell (GO:0002834)	2.84164557
58	positive regulation of response to tumor cell (GO:0002836)	2.84164557
59	tryptophan catabolic process (GO:0006569)	2.83912866
60	indole-containing compound catabolic process (GO:0042436)	2.83912866
61	indolalkylamine catabolic process (GO:0046218)	2.83912866
62	regulation of T cell migration (GO:2000404)	2.83802092
63	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.82734863
64	drug catabolic process (GO:0042737)	2.82197715
65	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.80749615
66	positive regulation of T-helper 1 type immune response (GO:0002827)	2.80316490
67	regulation of hypersensitivity (GO:0002883)	2.74566750
68	termination of RNA polymerase III transcription (GO:0006386)	2.74214711
69	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.74214711
70	positive regulation of fatty acid transport (GO:2000193)	2.73979747
71	neuron fate determination (GO:0048664)	2.72187711
72	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.71815474
73	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.67610006
74	signal peptide processing (GO:0006465)	2.66080778
75	positive regulation of T cell migration (GO:2000406)	2.63822337
76	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.63438516
77	necroptotic process (GO:0070266)	2.61852471
78	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.60763964
79	negative T cell selection (GO:0043383)	2.59368750
80	retinal cone cell development (GO:0046549)	2.57574640
81	regulation of cell killing (GO:0031341)	2.56292775
82	negative regulation of macrophage differentiation (GO:0045650)	2.55367636
83	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.54998779
84	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.51063515
85	hydrogen ion transmembrane transport (GO:1902600)	2.50199308
86	chaperone-mediated protein transport (GO:0072321)	2.50059647
87	synaptic transmission, cholinergic (GO:0007271)	2.50001688
88	negative thymic T cell selection (GO:0045060)	2.49419722
89	neural tube formation (GO:0001841)	2.47595360
90	water-soluble vitamin biosynthetic process (GO:0042364)	2.47471962
91	positive regulation of DNA recombination (GO:0045911)	2.44427175
92	mast cell activation involved in immune response (GO:0002279)	2.43770554
93	mast cell degranulation (GO:0043303)	2.43770554
94	positive regulation of respiratory burst (GO:0060267)	2.43593915
95	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.43123182
96	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.40792300
97	positive regulation of isotype switching (GO:0045830)	2.39890719
98	kidney morphogenesis (GO:0060993)	2.38888543
99	positive regulation of activated T cell proliferation (GO:0042104)	2.36501116
100	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.35837042

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	4.28230237
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.47376662
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.32782186
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.07538199
5	VDR_22108803_ChIP-Seq_LS180_Human	2.81995039
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.81775435
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.73425302
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.70386796
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.51610288
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.42493949
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.42349834
12	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.26079046
13	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.15583560
14	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.10434179
15	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.03845469
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.01676559
17	VDR_23849224_ChIP-Seq_CD4+_Human	1.98586385
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.98292868
19	ELK1_19687146_ChIP-ChIP_HELA_Human	1.96082420
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.92846337
21	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.91706299
22	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.91169079
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.79452743
24	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.78027810
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.77758902
26	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.75498545
27	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.67180543
28	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.60276174
29	EWS_26573619_Chip-Seq_HEK293_Human	1.58512700
30	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.55779250
31	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.51976750
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.48606953
33	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.48323431
34	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.47440335
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.46699270
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.46401417
37	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.44759275
38	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.41132161
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.40432302
40	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.37022141
41	NCOR_22424771_ChIP-Seq_293T_Human	1.32264891
42	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.31848669
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.29368185
44	ER_23166858_ChIP-Seq_MCF-7_Human	1.28687518
45	GATA3_26560356_Chip-Seq_TH2_Human	1.27851219
46	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.27285069
47	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.27204567
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26402158
49	ETV1_20927104_ChIP-Seq_GIST48_Human	1.25511565
50	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.24898287
51	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.22338035
52	AR_20517297_ChIP-Seq_VCAP_Human	1.20106905
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18887228
54	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.18382776
55	RBPJ_21746931_ChIP-Seq_IB4_Human	1.14959680
56	NANOG_20526341_ChIP-Seq_ESCs_Human	1.14197752
57	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.14138131
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.14138131
59	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13878758
60	EZH2_22144423_ChIP-Seq_EOC_Human	1.13664515
61	FUS_26573619_Chip-Seq_HEK293_Human	1.12643348
62	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.11642177
63	BCAT_22108803_ChIP-Seq_LS180_Human	1.10756837
64	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.10230686
65	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.06435055
66	GBX2_23144817_ChIP-Seq_PC3_Human	1.06206888
67	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.05486884
68	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.05064728
69	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.04619603
70	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.03987570
71	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03856603
72	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.02347411
73	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02000565
74	TCF4_22108803_ChIP-Seq_LS180_Human	1.01258328
75	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.01044296
76	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.99273720
77	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.98765002
78	P300_19829295_ChIP-Seq_ESCs_Human	0.97905690
79	SOX2_19829295_ChIP-Seq_ESCs_Human	0.97546229
80	NANOG_19829295_ChIP-Seq_ESCs_Human	0.97546229
81	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.97202708
82	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97151549
83	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95998944
84	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.94832200
85	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.94651626
86	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.94105336
87	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.93946886
88	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.93463151
89	ERA_21632823_ChIP-Seq_H3396_Human	0.92649625
90	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.91962779
91	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.91519474
92	TAF2_19829295_ChIP-Seq_ESCs_Human	0.89774198
93	P53_21459846_ChIP-Seq_SAOS-2_Human	0.89442283
94	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.88931321
95	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.88855476
96	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.88107970
97	PHF8_20622853_ChIP-Seq_HELA_Human	0.87927717
98	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.87271279
99	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.84888573
100	TTF2_22483619_ChIP-Seq_HELA_Human	0.84792591

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	4.88243125
2	MP0001835_abnormal_antigen_presentation	3.67921706
3	MP0000685_abnormal_immune_system	2.64519467
4	MP0002102_abnormal_ear_morphology	2.52286412
5	MP0008875_abnormal_xenobiotic_pharmacok	2.34935119
6	MP0005671_abnormal_response_to	2.31131556
7	MP0000372_irregular_coat_pigmentation	2.30571377
8	MP0004043_abnormal_pH_regulation	2.20662027
9	MP0002138_abnormal_hepatobiliary_system	2.13440598
10	MP0002638_abnormal_pupillary_reflex	2.05648051
11	MP0008877_abnormal_DNA_methylation	2.03472578
12	MP0003283_abnormal_digestive_organ	2.03218677
13	MP0004145_abnormal_muscle_electrophysio	2.03064481
14	MP0003195_calcinosis	1.98495946
15	MP0004885_abnormal_endolymph	1.92599494
16	MP0000604_amyloidosis	1.88930100
17	MP0002148_abnormal_hypersensitivity_rea	1.88112282
18	MP0005084_abnormal_gallbladder_morpholo	1.82813893
19	MP0006292_abnormal_olfactory_placode	1.82019686
20	MP0002876_abnormal_thyroid_physiology	1.75666532
21	MP0002163_abnormal_gland_morphology	1.63033495
22	MP0000465_gastrointestinal_hemorrhage	1.62170294
23	MP0006276_abnormal_autonomic_nervous	1.61455252
24	MP0003787_abnormal_imprinting	1.59853777
25	MP0005387_immune_system_phenotype	1.59021922
26	MP0001790_abnormal_immune_system	1.59021922
27	MP0009333_abnormal_splenocyte_physiolog	1.57987793
28	MP0009379_abnormal_foot_pigmentation	1.57201162
29	MP0005075_abnormal_melanosome_morpholog	1.52750898
30	MP0004142_abnormal_muscle_tone	1.51439749
31	MP0001800_abnormal_humoral_immune	1.50556051
32	MP0002653_abnormal_ependyma_morphology	1.48287333
33	MP0005551_abnormal_eye_electrophysiolog	1.45597587
34	MP0003806_abnormal_nucleotide_metabolis	1.44452767
35	MP0010386_abnormal_urinary_bladder	1.42517999
36	MP0001984_abnormal_olfaction	1.42489033
37	MP0005083_abnormal_biliary_tract	1.39722047
38	MP0005000_abnormal_immune_tolerance	1.38212933
39	MP0006072_abnormal_retinal_apoptosis	1.35044368
40	MP0003300_gastrointestinal_ulcer	1.32038831
41	MP0004147_increased_porphyrin_level	1.31967002
42	MP0003718_maternal_effect	1.31409459
43	MP0000538_abnormal_urinary_bladder	1.27588605
44	MP0003011_delayed_dark_adaptation	1.26953561
45	MP0002006_tumorigenesis	1.26716319
46	MP0002405_respiratory_system_inflammati	1.25729756
47	MP0005646_abnormal_pituitary_gland	1.22905478
48	MP0002234_abnormal_pharynx_morphology	1.22834620
49	MP0001853_heart_inflammation	1.20363304
50	MP0002723_abnormal_immune_serum	1.20102539
51	MP0002166_altered_tumor_susceptibility	1.19668216
52	MP0003786_premature_aging	1.17791942
53	MP0003252_abnormal_bile_duct	1.16104081
54	MP0008961_abnormal_basal_metabolism	1.11542878
55	MP0005645_abnormal_hypothalamus_physiol	1.10651621
56	MP0001968_abnormal_touch/_nociception	1.07928205
57	MP0003329_amyloid_beta_deposits	1.07889370
58	MP0005174_abnormal_tail_pigmentation	1.07865155
59	MP0005253_abnormal_eye_physiology	1.05444369
60	MP0008872_abnormal_physiological_respon	1.04083766
61	MP0003646_muscle_fatigue	1.02940108
62	MP0001845_abnormal_inflammatory_respons	1.01190087
63	MP0002938_white_spotting	1.00377965
64	MP0002452_abnormal_antigen_presenting	0.99809258
65	MP0001756_abnormal_urination	0.99477962
66	MP0002420_abnormal_adaptive_immunity	0.99457954
67	MP0010155_abnormal_intestine_physiology	0.99239909
68	MP0002139_abnormal_hepatobiliary_system	0.98579546
69	MP0001819_abnormal_immune_cell	0.97578044
70	MP0003866_abnormal_defecation	0.96895999
71	MP0006082_CNS_inflammation	0.96620460
72	MP0008789_abnormal_olfactory_epithelium	0.95129824
73	MP0005389_reproductive_system_phenotype	0.94916740
74	MP0002272_abnormal_nervous_system	0.93338885
75	MP0001905_abnormal_dopamine_level	0.90407380
76	MP0004742_abnormal_vestibular_system	0.89719792
77	MP0001873_stomach_inflammation	0.89522730
78	MP0009745_abnormal_behavioral_response	0.88948211
79	MP0005025_abnormal_response_to	0.88275490
80	MP0002160_abnormal_reproductive_system	0.88101444
81	MP0009785_altered_susceptibility_to	0.87086070
82	MP0004381_abnormal_hair_follicle	0.86283854
83	MP0002736_abnormal_nociception_after	0.85902879
84	MP0009046_muscle_twitch	0.85211237
85	MP0000689_abnormal_spleen_morphology	0.84991164
86	MP0002693_abnormal_pancreas_physiology	0.84256453
87	MP0003878_abnormal_ear_physiology	0.84183030
88	MP0005377_hearing/vestibular/ear_phenot	0.84183030
89	MP0003724_increased_susceptibility_to	0.83925913
90	MP0005085_abnormal_gallbladder_physiolo	0.83316639
91	MP0005332_abnormal_amino_acid	0.82131185
92	MP0000569_abnormal_digit_pigmentation	0.81953789
93	MP0001970_abnormal_pain_threshold	0.81850750
94	MP0001661_extended_life_span	0.81470885
95	MP0003638_abnormal_response/metabolism_	0.81150731
96	MP0002733_abnormal_thermal_nociception	0.78132372
97	MP0009764_decreased_sensitivity_to	0.76528318
98	MP0005379_endocrine/exocrine_gland_phen	0.75092674
99	MP0002398_abnormal_bone_marrow	0.74224235
100	MP0002837_dystrophic_cardiac_calcinosis	0.74078716

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Stomatitis (HP:0010280)	6.10193988
2	3-Methylglutaconic aciduria (HP:0003535)	4.44405424
3	Generalized aminoaciduria (HP:0002909)	4.41875594
4	Congenital stationary night blindness (HP:0007642)	4.32287198
5	Congenital, generalized hypertrichosis (HP:0004540)	3.72769549
6	IgG deficiency (HP:0004315)	3.69998075
7	Increased IgM level (HP:0003496)	3.69949841
8	Abnormality of the renal cortex (HP:0011035)	3.30757834
9	Renal cortical cysts (HP:0000803)	3.21949305
10	Acute necrotizing encephalopathy (HP:0006965)	3.18731371
11	Autoimmune thrombocytopenia (HP:0001973)	3.13047464
12	Hepatic necrosis (HP:0002605)	3.12835797
13	Mitochondrial inheritance (HP:0001427)	3.09131560
14	Lipid accumulation in hepatocytes (HP:0006561)	3.08003477
15	Pancreatic cysts (HP:0001737)	3.07023224
16	Nephronophthisis (HP:0000090)	3.04805931
17	Reduced antithrombin III activity (HP:0001976)	3.04225240
18	Increased hepatocellular lipid droplets (HP:0006565)	3.02132970
19	Increased CSF lactate (HP:0002490)	2.99782474
20	Abnormality of alanine metabolism (HP:0010916)	2.98235303
21	Hyperalaninemia (HP:0003348)	2.98235303
22	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.98235303
23	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.97362853
24	Severe combined immunodeficiency (HP:0004430)	2.85449932
25	Thyroiditis (HP:0100646)	2.81158899
26	Abnormal mitochondria in muscle tissue (HP:0008316)	2.79934712
27	Medial flaring of the eyebrow (HP:0010747)	2.79884732
28	Elevated erythrocyte sedimentation rate (HP:0003565)	2.73984453
29	Acute encephalopathy (HP:0006846)	2.70309109
30	Abnormality of the renal medulla (HP:0100957)	2.69626915
31	Tongue fasciculations (HP:0001308)	2.67631074
32	Progressive macrocephaly (HP:0004481)	2.66067719
33	Abnormality of T cell physiology (HP:0011840)	2.62774562
34	Autoimmune hemolytic anemia (HP:0001890)	2.60325327
35	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.57677786
36	Hepatocellular necrosis (HP:0001404)	2.57530968
37	Glycosuria (HP:0003076)	2.55932162
38	Abnormality of urine glucose concentration (HP:0011016)	2.55932162
39	Large eyes (HP:0001090)	2.48673483
40	Renal Fanconi syndrome (HP:0001994)	2.48354697
41	Type I transferrin isoform profile (HP:0003642)	2.48244183
42	Type 2 muscle fiber atrophy (HP:0003554)	2.47050359
43	Mesangial abnormality (HP:0001966)	2.46906110
44	Pancreatic fibrosis (HP:0100732)	2.45928142
45	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.45089786
46	Optic disc pallor (HP:0000543)	2.41339892
47	Abnormality of eosinophils (HP:0001879)	2.38206653
48	Abolished electroretinogram (ERG) (HP:0000550)	2.32974252
49	Abnormality of B cell number (HP:0010975)	2.32176648
50	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.30588989
51	Attenuation of retinal blood vessels (HP:0007843)	2.27044971
52	True hermaphroditism (HP:0010459)	2.27038121
53	Chronic hepatic failure (HP:0100626)	2.25642654
54	Exertional dyspnea (HP:0002875)	2.23093720
55	Muscle fibrillation (HP:0010546)	2.22598726
56	Abnormal rod and cone electroretinograms (HP:0008323)	2.22512753
57	Abnormality of T cells (HP:0002843)	2.19252823
58	Eosinophilia (HP:0001880)	2.17954929
59	Gait imbalance (HP:0002141)	2.17083866
60	Hypoproteinemia (HP:0003075)	2.15137625
61	Hypothermia (HP:0002045)	2.14985717
62	Limb dystonia (HP:0002451)	2.13958899
63	Constricted visual fields (HP:0001133)	2.13124525
64	Lactic acidosis (HP:0003128)	2.08337399
65	Joint swelling (HP:0001386)	2.06171031
66	Menstrual irregularities (HP:0000858)	2.05704485
67	Increased serum lactate (HP:0002151)	2.04343718
68	Pendular nystagmus (HP:0012043)	2.03981750
69	Muscle fiber atrophy (HP:0100295)	2.00860216
70	Increased intramyocellular lipid droplets (HP:0012240)	1.96005110
71	Abnormality of the labia minora (HP:0012880)	1.95140257
72	Severe muscular hypotonia (HP:0006829)	1.93447873
73	Combined immunodeficiency (HP:0005387)	1.93207770
74	Pachygyria (HP:0001302)	1.90414188
75	Tubular atrophy (HP:0000092)	1.87595222
76	Abnormality of T cell number (HP:0011839)	1.86281264
77	IgA deficiency (HP:0002720)	1.85443101
78	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.84571648
79	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.84571648
80	Polyuria (HP:0000103)	1.84154635
81	B lymphocytopenia (HP:0010976)	1.84097954
82	Cerebral edema (HP:0002181)	1.84084773
83	Congenital primary aphakia (HP:0007707)	1.83801460
84	Abnormal drinking behavior (HP:0030082)	1.83745108
85	Polydipsia (HP:0001959)	1.83745108
86	Abnormality of the pons (HP:0007361)	1.81210033
87	Molar tooth sign on MRI (HP:0002419)	1.80856569
88	Abnormality of midbrain morphology (HP:0002418)	1.80856569
89	Increased muscle lipid content (HP:0009058)	1.78982943
90	Testicular atrophy (HP:0000029)	1.76655991
91	Lethargy (HP:0001254)	1.74571228
92	Nephrogenic diabetes insipidus (HP:0009806)	1.73458133
93	Hypoplasia of the pons (HP:0012110)	1.73039392
94	Decreased central vision (HP:0007663)	1.72678858
95	Cerebral palsy (HP:0100021)	1.72566995
96	Abnormal protein glycosylation (HP:0012346)	1.72562095
97	Abnormal glycosylation (HP:0012345)	1.72562095
98	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.72562095
99	Abnormal protein N-linked glycosylation (HP:0012347)	1.72562095
100	Decreased circulating renin level (HP:0003351)	1.72461140

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	4.74563605
2	VRK2	4.23920427
3	NME2	3.76547875
4	BMPR1B	3.28108015
5	TLK1	2.36203207
6	TAF1	2.27155929
7	FRK	2.20748701
8	ADRBK2	2.14196353
9	TXK	2.12366984
10	ZAK	2.11151298
11	KIT	1.94064895
12	INSRR	1.91821496
13	WNK3	1.91521339
14	VRK1	1.86075716
15	FLT3	1.84604604
16	BCKDK	1.83772894
17	CAMKK2	1.79066116
18	MKNK1	1.61763427
19	GRK1	1.60890184
20	PASK	1.57180459
21	MAP4K2	1.51411751
22	ACVR1B	1.50104632
23	PHKG2	1.39677307
24	PHKG1	1.39677307
25	DYRK2	1.33077134
26	TIE1	1.32008315
27	PKN2	1.30657756
28	WNK4	1.30458267
29	IKBKB	1.25994489
30	MAP4K1	1.22821917
31	CDK8	1.22648082
32	PINK1	1.20654086
33	TGFBR1	1.17730642
34	KDR	1.16087403
35	IKBKE	1.15545277
36	MAPKAPK5	1.13740058
37	GRK6	1.13476895
38	SYK	1.11034413
39	MARK1	1.10840752
40	NUAK1	1.07486849
41	TNK2	0.98186909
42	MAPK13	0.96842873
43	DAPK2	0.96725821
44	TEC	0.94440312
45	FES	0.93012619
46	MAP3K4	0.92601305
47	NME1	0.92132812
48	LYN	0.91162652
49	MKNK2	0.89279641
50	MAP2K6	0.85101576
51	RPS6KA5	0.82340897
52	ITK	0.80475904
53	BTK	0.78964589
54	MAP3K14	0.77518052
55	RPS6KA4	0.77313661
56	STK16	0.74483947
57	ADRBK1	0.72023912
58	CAMKK1	0.70307414
59	TSSK6	0.65857743
60	CHUK	0.65097627
61	CSK	0.63339265
62	PRKCQ	0.63176085
63	BCR	0.62953136
64	AKT3	0.61163050
65	CSNK1G2	0.57116639
66	MATK	0.56818447
67	CSNK1G3	0.55085848
68	CDK9	0.55022470
69	MELK	0.54143104
70	TGFBR2	0.54142261
71	PRKCE	0.53422733
72	CSNK1A1L	0.51880001
73	LCK	0.50033908
74	ABL2	0.47341620
75	CDC7	0.46626784
76	BLK	0.45970146
77	EIF2AK2	0.45396536
78	MAP2K7	0.44459515
79	NTRK3	0.40638648
80	DYRK1A	0.40491342
81	MST4	0.38310602
82	PRKD3	0.38017518
83	PIM1	0.37917235
84	PAK3	0.37844654
85	NTRK2	0.36200758
86	BMPR2	0.36159149
87	OXSR1	0.35872116
88	MAP3K7	0.35630668
89	MARK3	0.35332080
90	CASK	0.34797515
91	OBSCN	0.30585875
92	PRKACA	0.30474405
93	STK38L	0.30436277
94	CSNK1A1	0.29987548
95	PRKCG	0.29830699
96	FGFR1	0.28926932
97	PRKG1	0.28215674
98	EPHA3	0.28165931
99	PRKCD	0.28016236
100	PRKCA	0.27867330

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Allograft rejection_Homo sapiens_hsa05330	3.54134044
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.35853336
3	Asthma_Homo sapiens_hsa05310	3.29413379
4	Proteasome_Homo sapiens_hsa03050	3.26134562
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.17158229
6	Type I diabetes mellitus_Homo sapiens_hsa04940	2.88748406
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.80921767
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.80470539
9	Parkinsons disease_Homo sapiens_hsa05012	2.75101762
10	Protein export_Homo sapiens_hsa03060	2.58757564
11	Ribosome_Homo sapiens_hsa03010	2.40482982
12	Primary immunodeficiency_Homo sapiens_hsa05340	2.26829147
13	Linoleic acid metabolism_Homo sapiens_hsa00591	2.22561792
14	Alzheimers disease_Homo sapiens_hsa05010	1.85618504
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.83557668
16	RNA polymerase_Homo sapiens_hsa03020	1.83214047
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.82598171
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.78305324
19	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.76655073
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.70431065
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.64588684
22	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.64377226
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.64219408
24	Huntingtons disease_Homo sapiens_hsa05016	1.56847421
25	Rheumatoid arthritis_Homo sapiens_hsa05323	1.52072012
26	Phototransduction_Homo sapiens_hsa04744	1.51172951
27	Caffeine metabolism_Homo sapiens_hsa00232	1.31278389
28	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.31190984
29	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.28654399
30	Antigen processing and presentation_Homo sapiens_hsa04612	1.25290017
31	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.22092007
32	Basal transcription factors_Homo sapiens_hsa03022	1.21797660
33	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.18419398
34	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.15691435
35	RNA degradation_Homo sapiens_hsa03018	1.14819222
36	Regulation of autophagy_Homo sapiens_hsa04140	1.08634580
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.03943913
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.01242051
39	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.00735988
40	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.00238229
41	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.96472187
42	Butanoate metabolism_Homo sapiens_hsa00650	0.92937190
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.88864072
44	Propanoate metabolism_Homo sapiens_hsa00640	0.85372718
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.84547149
46	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.84075265
47	Ether lipid metabolism_Homo sapiens_hsa00565	0.80441153
48	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.80153231
49	Nicotine addiction_Homo sapiens_hsa05033	0.78896050
50	Tryptophan metabolism_Homo sapiens_hsa00380	0.78871617
51	Nitrogen metabolism_Homo sapiens_hsa00910	0.78144838
52	Retinol metabolism_Homo sapiens_hsa00830	0.74774988
53	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.74118860
54	Pyrimidine metabolism_Homo sapiens_hsa00240	0.71810878
55	Olfactory transduction_Homo sapiens_hsa04740	0.71185700
56	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.65709997
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64399680
58	Fanconi anemia pathway_Homo sapiens_hsa03460	0.63861274
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62932906
60	Insulin secretion_Homo sapiens_hsa04911	0.62214434
61	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.61994875
62	Viral myocarditis_Homo sapiens_hsa05416	0.59680863
63	Mineral absorption_Homo sapiens_hsa04978	0.59241484
64	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.59121283
65	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.57098937
66	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.57072756
67	Purine metabolism_Homo sapiens_hsa00230	0.55584081
68	Fat digestion and absorption_Homo sapiens_hsa04975	0.54114135
69	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.51886069
70	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51726661
71	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.51442474
72	Taste transduction_Homo sapiens_hsa04742	0.50364007
73	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.49247687
74	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.48137130
75	Spliceosome_Homo sapiens_hsa03040	0.46017348
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.45238373
77	Homologous recombination_Homo sapiens_hsa03440	0.44742218
78	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.42802124
79	African trypanosomiasis_Homo sapiens_hsa05143	0.42597663
80	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.41570448
81	One carbon pool by folate_Homo sapiens_hsa00670	0.41371575
82	Metabolic pathways_Homo sapiens_hsa01100	0.40618104
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36782205
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.36703583
85	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.36539300
86	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.36025523
87	Measles_Homo sapiens_hsa05162	0.35222826
88	Peroxisome_Homo sapiens_hsa04146	0.34394617
89	TNF signaling pathway_Homo sapiens_hsa04668	0.34360267
90	Morphine addiction_Homo sapiens_hsa05032	0.34117982
91	RNA transport_Homo sapiens_hsa03013	0.31665420
92	beta-Alanine metabolism_Homo sapiens_hsa00410	0.30659382
93	Leishmaniasis_Homo sapiens_hsa05140	0.30169348
94	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.29028847
95	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.27800103
96	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.24960670
97	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.24811014
98	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.23182098
99	Serotonergic synapse_Homo sapiens_hsa04726	0.21842881
100	ABC transporters_Homo sapiens_hsa02010	0.21762191

UBA52P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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