UBA7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.99650054
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.99650054
3antigen processing and presentation of endogenous antigen (GO:0019883)6.52926292
4positive regulation of gamma-delta T cell activation (GO:0046645)6.32060231
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.62933624
6response to type I interferon (GO:0034340)4.84953990
7type I interferon signaling pathway (GO:0060337)4.78699773
8cellular response to type I interferon (GO:0071357)4.78699773
9regulation of gamma-delta T cell differentiation (GO:0045586)4.72448546
10antigen processing and presentation via MHC class Ib (GO:0002475)4.60743705
11regulation of gamma-delta T cell activation (GO:0046643)4.49780305
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.42491145
13detection of bacterium (GO:0016045)4.33761991
14ribosomal small subunit assembly (GO:0000028)4.30674917
15response to interferon-beta (GO:0035456)4.28908880
16positive regulation of B cell differentiation (GO:0045579)4.28530148
17detection of other organism (GO:0098543)4.27413500
18definitive hemopoiesis (GO:0060216)4.10676222
19regulation of B cell receptor signaling pathway (GO:0050855)4.03981065
20response to interferon-alpha (GO:0035455)4.01825681
21positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.00669368
22negative regulation of erythrocyte differentiation (GO:0045647)3.93285514
23regulation of dendritic cell antigen processing and presentation (GO:0002604)3.84787377
24NIK/NF-kappaB signaling (GO:0038061)3.80924159
25regulation of interleukin-12 biosynthetic process (GO:0045075)3.79819528
26megakaryocyte development (GO:0035855)3.79083088
27negative regulation of cell killing (GO:0031342)3.76016796
28negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.76016796
29regulation of B cell differentiation (GO:0045577)3.75717106
30interferon-gamma-mediated signaling pathway (GO:0060333)3.65528280
31macrophage activation involved in immune response (GO:0002281)3.63321195
32cellular response to interferon-beta (GO:0035458)3.61714642
33regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.61603438
34negative thymic T cell selection (GO:0045060)3.58276039
35immunoglobulin mediated immune response (GO:0016064)3.57760291
36positive regulation of interferon-alpha production (GO:0032727)3.56874243
37regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.56088416
38B cell receptor signaling pathway (GO:0050853)3.54083000
39negative T cell selection (GO:0043383)3.49867114
40defense response to protozoan (GO:0042832)3.48874864
41regulation of type I interferon-mediated signaling pathway (GO:0060338)3.45764362
42T cell migration (GO:0072678)3.44365990
43positive T cell selection (GO:0043368)3.43403119
44negative regulation of viral genome replication (GO:0045071)3.40623887
45detection of external biotic stimulus (GO:0098581)3.40611270
46regulation of interferon-beta biosynthetic process (GO:0045357)3.40608994
47negative regulation of lymphocyte mediated immunity (GO:0002707)3.40000280
48cellular extravasation (GO:0045123)3.39417814
49regulation of interferon-alpha production (GO:0032647)3.37254991
50mature B cell differentiation (GO:0002335)3.34784234
51response to protozoan (GO:0001562)3.31924263
52response to interleukin-15 (GO:0070672)3.29903652
53positive regulation of natural killer cell differentiation (GO:0032825)3.29494962
54negative regulation of interleukin-12 production (GO:0032695)3.29222302
55myeloid dendritic cell activation (GO:0001773)3.27843162
56positive thymic T cell selection (GO:0045059)3.27798761
57negative regulation of T cell mediated immunity (GO:0002710)3.26603269
58negative regulation of leukocyte mediated immunity (GO:0002704)3.24267205
59mature B cell differentiation involved in immune response (GO:0002313)3.21670103
60positive regulation of antigen processing and presentation (GO:0002579)3.18953255
61regulation of mast cell degranulation (GO:0043304)3.18915606
62response to host immune response (GO:0052572)3.14677465
63response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.14677465
64myeloid cell activation involved in immune response (GO:0002275)3.10687657
65T cell homeostasis (GO:0043029)3.10508847
66JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.10172693
67regulation of RIG-I signaling pathway (GO:0039535)3.08615116
68regulation of myeloid leukocyte mediated immunity (GO:0002886)3.07765724
69regulation of alpha-beta T cell proliferation (GO:0046640)3.07125966
70negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.05177403
71microglial cell activation (GO:0001774)3.00486971
72regulation of response to interferon-gamma (GO:0060330)2.99663489
73neutrophil activation (GO:0042119)2.99461971
74myeloid dendritic cell differentiation (GO:0043011)2.98571768
75detection of biotic stimulus (GO:0009595)2.98149578
76negative regulation of innate immune response (GO:0045824)2.97827834
77lymph node development (GO:0048535)2.96494417
78response to host (GO:0075136)2.94218460
79response to host defenses (GO:0052200)2.94218460
80response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.94218460
81regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.93871440
82regulation of leukocyte degranulation (GO:0043300)2.90045544
83regulation of mast cell activation involved in immune response (GO:0033006)2.89153343
84regulation of tolerance induction (GO:0002643)2.89024868
85regulation of T cell tolerance induction (GO:0002664)2.88729080
86regulation of erythrocyte differentiation (GO:0045646)2.88584963
87cellular response to exogenous dsRNA (GO:0071360)2.88151457
88B cell mediated immunity (GO:0019724)2.87802955
89regulation of regulatory T cell differentiation (GO:0045589)2.87486772
90positive regulation of interferon-beta production (GO:0032728)2.87296679
91response to muramyl dipeptide (GO:0032495)2.87235477
92respiratory burst (GO:0045730)2.86471552
93cellular response to interleukin-15 (GO:0071350)2.86027150
94lymphocyte homeostasis (GO:0002260)2.84577369
95mast cell activation (GO:0045576)2.84201804
96regulation of necroptotic process (GO:0060544)2.82911048
97negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.82456771
98negative regulation of T-helper cell differentiation (GO:0045623)2.82456771
99negative regulation of phagocytosis (GO:0050765)2.82029453
100positive regulation of humoral immune response (GO:0002922)2.81777320
101tolerance induction (GO:0002507)2.81761800
102regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.81725749
103platelet dense granule organization (GO:0060155)2.80794456
104positive regulation of type 2 immune response (GO:0002830)2.80644058
105thymic T cell selection (GO:0045061)2.78308604
106regulation of T cell mediated cytotoxicity (GO:0001914)2.76843988
107embryonic hemopoiesis (GO:0035162)2.76790140
108leukocyte degranulation (GO:0043299)2.76776911
109regulation of natural killer cell differentiation (GO:0032823)2.76257765
110leukocyte aggregation (GO:0070486)2.74614021
111interferon-gamma production (GO:0032609)2.73889511
112granulocyte activation (GO:0036230)2.73363342
113regulation of antigen processing and presentation (GO:0002577)2.72909873
114leukocyte homeostasis (GO:0001776)2.72319933
115positive regulation by symbiont of host defense response (GO:0052509)2.71574830
116modulation by symbiont of host defense response (GO:0052031)2.71574830
117modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.71574830
118modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.71574830
119positive regulation by organism of defense response of other organism involved in symbiotic interact2.71574830
120modulation by symbiont of host immune response (GO:0052553)2.71574830
121Peyers patch development (GO:0048541)2.71376493
122mucosal-associated lymphoid tissue development (GO:0048537)2.71376493
123neutrophil activation involved in immune response (GO:0002283)2.70670951
124regulation of T cell receptor signaling pathway (GO:0050856)2.70588358
125Arp2/3 complex-mediated actin nucleation (GO:0034314)2.68454045
126T cell selection (GO:0045058)2.65788120
127response to peptidoglycan (GO:0032494)2.64979041
128positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.64768945
129dendritic cell differentiation (GO:0097028)2.63949262
130positive regulation of defense response to virus by host (GO:0002230)2.63528810
131positive regulation of granulocyte differentiation (GO:0030854)2.60913820
132cellular response to interferon-gamma (GO:0071346)2.60448367
133regulation of T-helper 1 cell differentiation (GO:0045625)2.60345295
134antigen receptor-mediated signaling pathway (GO:0050851)2.60173017
135B cell homeostasis (GO:0001782)2.59020301
136positive regulation of isotype switching (GO:0045830)2.58394536
137positive regulation of T cell mediated cytotoxicity (GO:0001916)2.58357364
138positive regulation of natural killer cell activation (GO:0032816)2.55616883
139viral transcription (GO:0019083)2.55293637
140germinal center formation (GO:0002467)2.55052486

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.83822412
2IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.34381172
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.92422610
4SCL_19346495_ChIP-Seq_HPC-7_Human3.79893536
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.76873704
6* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.75694093
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.72978928
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.65246484
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.41150716
10GATA1_22025678_ChIP-Seq_K562_Human3.34563264
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.93790974
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.72964131
13* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.71715030
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.61073803
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.60279488
16E2F7_22180533_ChIP-Seq_HELA_Human2.53352753
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.51423156
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51116008
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.50554179
20MYC_22102868_ChIP-Seq_BL_Human2.49098649
21VDR_21846776_ChIP-Seq_THP-1_Human2.46098634
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.36281083
23MYB_26560356_Chip-Seq_TH2_Human2.34565393
24MAF_26560356_Chip-Seq_TH1_Human2.30886061
25SPI1_23547873_ChIP-Seq_NB4_Human2.26374638
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.22589460
27RUNX_20019798_ChIP-Seq_JUKART_Human2.19588975
28MYB_26560356_Chip-Seq_TH1_Human2.10337858
29* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.10329217
30EGR1_19374776_ChIP-ChIP_THP-1_Human2.04752899
31* RUNX1_22412390_ChIP-Seq_EML_Mouse2.00538551
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.99894330
33VDR_24763502_ChIP-Seq_THP-1_Human1.98819570
34* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.98089864
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.91000504
36UTX_26944678_Chip-Seq_JUKART_Human1.90377222
37* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.86606499
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.86513094
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83252032
40* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.82630082
41TCF7_22412390_ChIP-Seq_EML_Mouse1.79086454
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77175221
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76817527
44GATA1_22383799_ChIP-Seq_G1ME_Mouse1.76801898
45GATA1_19941827_ChIP-Seq_MEL_Mouse1.74366973
46* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.69173556
47TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.69169748
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66111043
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.64818679
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.64321644
51LXR_22292898_ChIP-Seq_THP-1_Human1.63844399
52SPI1_23127762_ChIP-Seq_K562_Human1.62603778
53EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.56089621
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53840795
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47852732
56* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.47258275
57MAF_26560356_Chip-Seq_TH2_Human1.46578423
58GATA3_27048872_Chip-Seq_THYMUS_Human1.41790020
59GATA1_19941826_ChIP-Seq_K562_Human1.38933575
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.35939408
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35096391
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34892416
63PU_27001747_Chip-Seq_BMDM_Mouse1.31760675
64* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28626010
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.26566506
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25472790
67CIITA_25753668_ChIP-Seq_RAJI_Human1.25453302
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.24105243
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23467715
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23229520
71Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22093725
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21852570
73BCOR_27268052_Chip-Seq_Bcells_Human1.19841604
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18545581
75ELF1_20517297_ChIP-Seq_JURKAT_Human1.17691576
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16952247
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16462110
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13762442
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11719575
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.10174550
81SMAD_19615063_ChIP-ChIP_OVARY_Human1.09264495
82GATA2_19941826_ChIP-Seq_K562_Human1.06796988
83KDM2B_26808549_Chip-Seq_DND41_Human1.06638257
84* GATA3_26560356_Chip-Seq_TH2_Human1.06341365
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05600571
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03880199
87KDM2B_26808549_Chip-Seq_JURKAT_Human1.03053754
88KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98548771
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97494817
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97361260
91PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95035775
92SA1_27219007_Chip-Seq_ERYTHROID_Human0.95025021
93RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94507332
94PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94269241
95NCOR1_26117541_ChIP-Seq_K562_Human0.93872970
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93788907
97P68_20966046_ChIP-Seq_HELA_Human0.92446666
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92248880
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91989267
100PPARA_22158963_ChIP-Seq_LIVER_Mouse0.90813040
101VDR_23849224_ChIP-Seq_CD4+_Human0.90611329
102FOXP3_21729870_ChIP-Seq_TREG_Human0.88493257
103TFEB_21752829_ChIP-Seq_HELA_Human0.86595329
104GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86511533
105CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85952261
106CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85289944
107FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.84888721
108ETS1_22383799_ChIP-Seq_G1ME_Mouse0.84865036
109PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84311979
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83515659
111BCL6_27268052_Chip-Seq_Bcells_Human0.79613077
112PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77797703
113RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.77060307
114EGR1_23403033_ChIP-Seq_LIVER_Mouse0.75166911
115CTCF_21964334_ChIP-Seq_BJAB-B_Human0.69264335
116RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69006166
117VDR_24787735_ChIP-Seq_THP-1_Human0.67949575

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.29744715
2MP0000685_abnormal_immune_system3.47141739
3MP0005671_abnormal_response_to3.21802440
4MP0009785_altered_susceptibility_to3.17707820
5MP0001800_abnormal_humoral_immune2.93234075
6MP0005387_immune_system_phenotype2.83759310
7MP0001790_abnormal_immune_system2.83759310
8MP0002396_abnormal_hematopoietic_system2.81616624
9MP0005025_abnormal_response_to2.72788122
10MP0005000_abnormal_immune_tolerance2.67722482
11MP0002452_abnormal_antigen_presenting2.62005494
12MP0005464_abnormal_platelet_physiology2.59923400
13MP0002166_altered_tumor_susceptibility2.58538069
14MP0003436_decreased_susceptibility_to2.58077083
15MP0003763_abnormal_thymus_physiology2.58052432
16MP0002723_abnormal_immune_serum2.57232998
17MP0002420_abnormal_adaptive_immunity2.47681488
18MP0001819_abnormal_immune_cell2.46301806
19MP0002398_abnormal_bone_marrow2.41806187
20MP0002148_abnormal_hypersensitivity_rea2.38076038
21MP0004510_myositis2.36163642
22MP0002419_abnormal_innate_immunity2.33459282
23MP0004808_abnormal_hematopoietic_stem2.26478331
24MP0003724_increased_susceptibility_to2.22463783
25MP0001873_stomach_inflammation2.13634705
26MP0000716_abnormal_immune_system2.13125278
27MP0001545_abnormal_hematopoietic_system2.10917389
28MP0005397_hematopoietic_system_phenotyp2.10917389
29MP0000689_abnormal_spleen_morphology2.05525151
30MP0006082_CNS_inflammation1.96862934
31MP0002006_tumorigenesis1.96402879
32MP0010155_abnormal_intestine_physiology1.93729534
33MP0002722_abnormal_immune_system1.93089710
34MP0005174_abnormal_tail_pigmentation1.92319446
35MP0002405_respiratory_system_inflammati1.88831844
36MP0002429_abnormal_blood_cell1.88285176
37MP0000465_gastrointestinal_hemorrhage1.86842345
38MP0004947_skin_inflammation1.85400837
39MP0009278_abnormal_bone_marrow1.80706318
40MP0001853_heart_inflammation1.75272336
41MP0004147_increased_porphyrin_level1.72742789
42MP0003656_abnormal_erythrocyte_physiolo1.71586442
43MP0001845_abnormal_inflammatory_respons1.71534994
44MP0009333_abnormal_splenocyte_physiolog1.63524017
45MP0003300_gastrointestinal_ulcer1.56567543
46MP0003303_peritoneal_inflammation1.53978514
47MP0008469_abnormal_protein_level1.52656759
48MP0000703_abnormal_thymus_morphology1.50692617
49MP0003866_abnormal_defecation1.44981771
50MP0005310_abnormal_salivary_gland1.43356657
51MP0003191_abnormal_cellular_cholesterol1.40156935
52MP0008260_abnormal_autophagy1.37202552
53MP0005075_abnormal_melanosome_morpholog1.35782974
54MP0003172_abnormal_lysosome_physiology1.26774458
55MP0005058_abnormal_lysosome_morphology1.25940857
56MP0001533_abnormal_skeleton_physiology1.25375155
57MP0000490_abnormal_crypts_of1.24908891
58MP0008004_abnormal_stomach_pH1.22810623
59MP0009764_decreased_sensitivity_to1.18137556
60MP0002933_joint_inflammation1.13048656
61MP0002095_abnormal_skin_pigmentation1.13032260
62MP0004883_abnormal_blood_vessel1.09218062
63MP0000343_altered_response_to1.06392279
64MP0003448_altered_tumor_morphology1.05600624
65MP0000858_altered_metastatic_potential1.03493030
66MP0000015_abnormal_ear_pigmentation1.00383028
67MP0005451_abnormal_body_composition0.97973607
68MP0005390_skeleton_phenotype0.97923434
69MP0009763_increased_sensitivity_to0.96652056
70MP0002877_abnormal_melanocyte_morpholog0.95242584
71MP0000569_abnormal_digit_pigmentation0.94255220
72MP0006054_spinal_hemorrhage0.93986389
73MP0002138_abnormal_hepatobiliary_system0.93257691
74MP0003806_abnormal_nucleotide_metabolis0.91710912
75MP0002019_abnormal_tumor_incidence0.91324275
76MP0005360_urolithiasis0.90280885
77MP0005164_abnormal_response_to0.90253630
78MP0000604_amyloidosis0.88072515
79MP0003828_pulmonary_edema0.80690431
80MP0002009_preneoplasia0.80356826
81MP0003279_aneurysm0.79539207
82MP0001851_eye_inflammation0.77505801
83MP0003943_abnormal_hepatobiliary_system0.77324638
84MP0002132_abnormal_respiratory_system0.76341244
85MP0002998_abnormal_bone_remodeling0.75884477
86MP0004381_abnormal_hair_follicle0.74660540
87MP0009765_abnormal_xenobiotic_induced0.74622966
88MP0009840_abnormal_foam_cell0.73834222
89MP0003690_abnormal_glial_cell0.72977592
90MP0001986_abnormal_taste_sensitivity0.72327954
91MP0003091_abnormal_cell_migration0.70923705
92MP0000371_diluted_coat_color0.70184272
93MP0001879_abnormal_lymphatic_vessel0.69883812
94MP0003795_abnormal_bone_structure0.69782055
95MP0010307_abnormal_tumor_latency0.69610158
96MP0000249_abnormal_blood_vessel0.69597026
97MP0003252_abnormal_bile_duct0.69300768
98MP0002254_reproductive_system_inflammat0.68431257
99MP0003183_abnormal_peptide_metabolism0.68391586
100MP0005381_digestive/alimentary_phenotyp0.67387411
101MP0001958_emphysema0.66671008
102MP0002136_abnormal_kidney_physiology0.66373164
103MP0005166_decreased_susceptibility_to0.65860460
104MP0000598_abnormal_liver_morphology0.65610549
105MP0003566_abnormal_cell_adhesion0.63659708
106MP0010368_abnormal_lymphatic_system0.63643823
107MP0000609_abnormal_liver_physiology0.63098340
108MP0001663_abnormal_digestive_system0.62990161
109MP0008874_decreased_physiological_sensi0.62490054
110MP0005023_abnormal_wound_healing0.61059512
111MP0002139_abnormal_hepatobiliary_system0.59972334
112MP0010352_gastrointestinal_tract_polyps0.59138451
113MP0008058_abnormal_DNA_repair0.59050270
114MP0008007_abnormal_cellular_replicative0.58233568
115MP0003075_altered_response_to0.57989175
116MP0005535_abnormal_body_temperature0.56583314
117* MP0000313_abnormal_cell_death0.56577361
118MP0003045_fibrosis0.55737568
119MP0001348_abnormal_lacrimal_gland0.55552274
120MP0001191_abnormal_skin_condition0.52665528
121MP0003453_abnormal_keratinocyte_physiol0.51635528

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)5.21166444
2Elevated erythrocyte sedimentation rate (HP:0003565)4.55419841
3Thrombocytosis (HP:0001894)4.50915274
4Myositis (HP:0100614)4.36790928
5Recurrent abscess formation (HP:0002722)4.26230137
6Recurrent viral infections (HP:0004429)4.22848231
7Prolonged bleeding time (HP:0003010)4.13869003
8Recurrent bronchitis (HP:0002837)4.09980519
9Abnormality of the nasal mucosa (HP:0000433)4.04092577
10Nasal polyposis (HP:0100582)4.00964764
11Petechiae (HP:0000967)3.96840517
12Recurrent fungal infections (HP:0002841)3.95731308
13Recurrent bacterial skin infections (HP:0005406)3.92482274
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.85927103
15Eczematoid dermatitis (HP:0000976)3.79197741
16Agammaglobulinemia (HP:0004432)3.75405793
17IgM deficiency (HP:0002850)3.71782622
18Autoimmune thrombocytopenia (HP:0001973)3.58309432
19Panhypogammaglobulinemia (HP:0003139)3.56433056
20Epistaxis (HP:0000421)3.50419328
21Abnormal platelet function (HP:0011869)3.49791059
22Impaired platelet aggregation (HP:0003540)3.49791059
23Recurrent cutaneous fungal infections (HP:0011370)3.48970059
24Chronic mucocutaneous candidiasis (HP:0002728)3.48970059
25Stomatitis (HP:0010280)3.34163046
26Colitis (HP:0002583)3.22764418
27Recurrent skin infections (HP:0001581)3.22017402
28Gingival bleeding (HP:0000225)3.19928084
29Inflammation of the large intestine (HP:0002037)3.19028466
30Orchitis (HP:0100796)3.18882269
31Vasculitis (HP:0002633)3.16902766
32Cellulitis (HP:0100658)3.16783046
33Gastrointestinal infarctions (HP:0005244)3.16218169
34Abnormality of T cells (HP:0002843)3.16154700
35Systemic lupus erythematosus (HP:0002725)3.15226773
36Gastrointestinal inflammation (HP:0004386)3.13404915
37Abnormality of the fingertips (HP:0001211)3.13381538
38Pustule (HP:0200039)3.12828536
39Abnormality of T cell physiology (HP:0011840)3.08311412
40Meningitis (HP:0001287)3.06812067
41Spontaneous hematomas (HP:0007420)3.05448632
42Optic neuritis (HP:0100653)3.01806028
43Retrobulbar optic neuritis (HP:0100654)3.01806028
44T lymphocytopenia (HP:0005403)3.00270279
45Abnormality of T cell number (HP:0011839)3.00139291
46Chronic sinusitis (HP:0011109)2.90999900
47Urticaria (HP:0001025)2.82391086
48Gastrointestinal stroma tumor (HP:0100723)2.80835072
49Mediastinal lymphadenopathy (HP:0100721)2.77490223
50Abnormality of macrophages (HP:0004311)2.73620334
51Abnormality of the heme biosynthetic pathway (HP:0010472)2.72156979
52Increased IgE level (HP:0003212)2.71400215
53Arterial thrombosis (HP:0004420)2.70930550
54Lymphopenia (HP:0001888)2.70301042
55Interstitial pulmonary disease (HP:0006530)2.67150312
56Periodontitis (HP:0000704)2.62365028
57Abnormality of cells of the lymphoid lineage (HP:0012140)2.61489430
58Leukocytosis (HP:0001974)2.60703141
59Increased IgM level (HP:0003496)2.59268169
60B lymphocytopenia (HP:0010976)2.54291035
61Abnormality of B cell number (HP:0010975)2.54291035
62Thyroiditis (HP:0100646)2.51213110
63Granulocytopenia (HP:0001913)2.49669009
64Purpura (HP:0000979)2.49448446
65IgG deficiency (HP:0004315)2.48054790
66Encephalitis (HP:0002383)2.47803613
67Hemoptysis (HP:0002105)2.45193695
68Recurrent gram-negative bacterial infections (HP:0005420)2.44948145
69Pulmonary infiltrates (HP:0002113)2.38745236
70Abnormality of eosinophils (HP:0001879)2.38401512
71Emphysema (HP:0002097)2.38119698
72Chronic diarrhea (HP:0002028)2.37973221
73Albinism (HP:0001022)2.37516115
74Abnormal platelet volume (HP:0011876)2.37316000
75Verrucae (HP:0200043)2.37219594
76Papilloma (HP:0012740)2.37219594
77Hematochezia (HP:0002573)2.35218734
78Eosinophilia (HP:0001880)2.33993299
79Pulmonary embolism (HP:0002204)2.33744284
80Menorrhagia (HP:0000132)2.32788551
81Severe combined immunodeficiency (HP:0004430)2.32241748
82Amaurosis fugax (HP:0100576)2.31017142
83Dysostosis multiplex (HP:0000943)2.30634500
84Microcytic anemia (HP:0001935)2.30090368
85Chest pain (HP:0100749)2.29540900
86Autoimmune hemolytic anemia (HP:0001890)2.28314299
87Osteomyelitis (HP:0002754)2.25977438
88Abnormality of the prostate (HP:0008775)2.25740506
89Hypergammaglobulinemia (HP:0010702)2.24647802
90Abnormality of the pleura (HP:0002103)2.22940145
91Sepsis (HP:0100806)2.22134239
92Keratoconjunctivitis sicca (HP:0001097)2.21987037
93Restrictive lung disease (HP:0002091)2.21240881
94Acute myeloid leukemia (HP:0004808)2.21121939
95IgA deficiency (HP:0002720)2.21116013
96Bronchitis (HP:0012387)2.20562426
97Increased neuronal autofluorescent lipopigment (HP:0002074)2.19767689
98Loss of speech (HP:0002371)2.19566904
99Combined immunodeficiency (HP:0005387)2.19341071
100Recurrent sinusitis (HP:0011108)2.18701050
101Abnormality of liposaccharide metabolism (HP:0010968)2.18580601
102Abnormality of glycosphingolipid metabolism (HP:0004343)2.18580601
103Abnormality of glycolipid metabolism (HP:0010969)2.18580601
104Skin rash (HP:0000988)2.18498988
105Abnormal number of erythroid precursors (HP:0012131)2.17874069
106Fatigue (HP:0012378)2.17311002
107Skin ulcer (HP:0200042)2.17044287
108Increased cerebral lipofuscin (HP:0011813)2.16002015
109Abnormality of cells of the erythroid lineage (HP:0012130)2.15719523
110Poikilocytosis (HP:0004447)2.13005742
111Keratoconjunctivitis (HP:0001096)2.12629217
112Hepatosplenomegaly (HP:0001433)2.12460948
113Hypochromic anemia (HP:0001931)2.11393788
114Recurrent lower respiratory tract infections (HP:0002783)2.11253210
115Chronic obstructive pulmonary disease (HP:0006510)2.10139470
116Obstructive lung disease (HP:0006536)2.10139470
117Vacuolated lymphocytes (HP:0001922)2.09857568
118Increased serum ferritin (HP:0003281)2.09449627
119Lymphoma (HP:0002665)2.08874824
120Recurrent pneumonia (HP:0006532)2.05905808
121Abnormality of iron homeostasis (HP:0011031)2.03733547
122Polygenic inheritance (HP:0010982)2.03547665
123Viral hepatitis (HP:0006562)2.03414411
124Amyloidosis (HP:0011034)2.03196081
125Gingivitis (HP:0000230)2.01542367
126Reticulocytopenia (HP:0001896)2.01418647
127Papilledema (HP:0001085)2.01202399
128Episodic fever (HP:0001954)1.99132884
129Abnormality of the peritoneum (HP:0002585)1.95580773

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.27998016
2TYK23.33429710
3KIT3.11201326
4JAK32.96157520
5IKBKE2.87859046
6MAP3K142.71739652
7TBK12.65159384
8PRPF4B2.58925840
9TXK2.42430455
10MAP3K132.39468614
11TGFBR22.23118851
12JAK12.10207337
13IRAK42.07139862
14FGFR42.05978986
15BTK2.03632867
16ZAP701.98774316
17IKBKB1.93583624
18EEF2K1.92291670
19IRAK31.86939352
20SYK1.84712075
21BLK1.82684334
22TEC1.79512514
23TAOK31.79004682
24CSF1R1.77087000
25TGFBR11.65503740
26TIE11.64631367
27FLT31.52453305
28ERN11.51861859
29STK101.46724363
30NME21.37058411
31LCK1.33515495
32MAP3K111.32173523
33MAP2K31.29282674
34FGFR31.27446062
35HCK1.24948362
36MAP3K31.23882104
37RIPK41.23681444
38GRK61.21150152
39PIM11.19690835
40CHUK1.17556594
41EPHB11.17265625
42ITK1.15217563
43TESK21.14130218
44LRRK21.13999587
45CSK1.12631393
46MATK1.11252010
47NLK1.09094363
48BMPR21.07099184
49CDC42BPA1.06486951
50LYN1.05963548
51MAP3K101.05522670
52KDR1.03124897
53FES1.00272067
54FGR0.96411662
55JAK20.96222164
56PRKD20.95727406
57MAP3K10.95163900
58SIK20.94504955
59TAOK10.92041483
60MAPK70.89248592
61PKN20.87948955
62RPS6KA40.85585335
63MAPK120.82231613
64MARK20.80834493
65RPS6KB20.77774395
66MAP3K70.76807952
67EPHA30.76651406
68PIK3CG0.75023068
69MAP3K60.74848349
70SMG10.74075167
71PIM20.71707955
72TAOK20.71299989
73STK40.70529562
74MUSK0.69057664
75CLK10.68717795
76PDPK10.68174173
77TRPM70.61614627
78MAPK110.59917791
79PTK60.59386271
80FYN0.59355439
81RIPK10.58204462
82ACVR1B0.57856212
83MAP2K20.56215204
84HIPK20.55887629
85RPS6KA60.52375836
86PTK2B0.51275166
87BMX0.51087446
88PRKG20.49953638
89MARK30.49569236
90MAP2K60.47980258
91DYRK1B0.46529885
92NEK90.46373343
93CDK40.46284455
94BRD40.45900052
95CDK90.45048085
96SIK30.44841660
97MAP3K50.44676823
98YES10.44670920
99PDK10.44360708
100GRK70.44211289
101RPS6KA50.43345456
102PRKAA20.41580523
103RPS6KA20.41575466
104TTN0.40215599
105PRKCQ0.40060229
106TNK20.39607523
107IRAK10.39542880
108CAMKK20.39505930
109CDK60.38860287
110CAMK1D0.37657339
111MAPKAPK30.37612860
112RET0.37532897
113RPS6KC10.36689453
114RPS6KL10.36689453
115MAPKAPK50.36148406
116MAPK40.35861275
117EIF2AK10.33463366
118PRKD10.32927950
119ADRBK20.32323004
120ATR0.32021416
121MAPK30.31435825
122CDK120.31145284
123MAPKAPK20.30849139
124EIF2AK20.30835217
125TRIB30.30431992
126DAPK20.29963783
127SIK10.29618127
128PRKCD0.29553291
129CDK190.29069395
130NUAK10.27615284
131ABL10.27358979

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.79637483
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.77986832
3Measles_Homo sapiens_hsa051622.75291768
4Leishmaniasis_Homo sapiens_hsa051402.73999283
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.64425147
6B cell receptor signaling pathway_Homo sapiens_hsa046622.61890491
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.51621952
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.39646397
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.33664802
10Antigen processing and presentation_Homo sapiens_hsa046122.28786627
11Hematopoietic cell lineage_Homo sapiens_hsa046402.24736575
12Osteoclast differentiation_Homo sapiens_hsa043802.23291664
13Herpes simplex infection_Homo sapiens_hsa051682.15342118
14Toll-like receptor signaling pathway_Homo sapiens_hsa046202.12014979
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.94174467
16Influenza A_Homo sapiens_hsa051641.86356506
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.77733753
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.76893373
19Allograft rejection_Homo sapiens_hsa053301.75457951
20Ribosome_Homo sapiens_hsa030101.60472452
21Toxoplasmosis_Homo sapiens_hsa051451.57673806
22T cell receptor signaling pathway_Homo sapiens_hsa046601.56214838
23Caffeine metabolism_Homo sapiens_hsa002321.51858260
24Staphylococcus aureus infection_Homo sapiens_hsa051501.50709511
25Legionellosis_Homo sapiens_hsa051341.45762531
26Acute myeloid leukemia_Homo sapiens_hsa052211.45034680
27Pertussis_Homo sapiens_hsa051331.43404155
28Malaria_Homo sapiens_hsa051441.42923062
29Apoptosis_Homo sapiens_hsa042101.42283417
30TNF signaling pathway_Homo sapiens_hsa046681.39435166
31Hepatitis B_Homo sapiens_hsa051611.39036901
32Graft-versus-host disease_Homo sapiens_hsa053321.35151462
33Platelet activation_Homo sapiens_hsa046111.30648821
34DNA replication_Homo sapiens_hsa030301.28055118
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27629634
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25919988
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24787679
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24337829
39Tuberculosis_Homo sapiens_hsa051521.24064698
40Hepatitis C_Homo sapiens_hsa051601.23740302
41Chemokine signaling pathway_Homo sapiens_hsa040621.23102625
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.21172007
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17906393
44Shigellosis_Homo sapiens_hsa051311.17245719
45Other glycan degradation_Homo sapiens_hsa005111.14743290
46Phagosome_Homo sapiens_hsa041451.03721341
47ABC transporters_Homo sapiens_hsa020101.02059771
48Base excision repair_Homo sapiens_hsa034101.02029241
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.00049467
50Asthma_Homo sapiens_hsa053100.96806152
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96475465
52Chronic myeloid leukemia_Homo sapiens_hsa052200.93596769
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88334714
54Prolactin signaling pathway_Homo sapiens_hsa049170.87207602
55Epstein-Barr virus infection_Homo sapiens_hsa051690.86849439
56African trypanosomiasis_Homo sapiens_hsa051430.86294976
57Viral myocarditis_Homo sapiens_hsa054160.84527316
58Mismatch repair_Homo sapiens_hsa034300.82310584
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80089284
60Pancreatic cancer_Homo sapiens_hsa052120.80079023
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79441570
62Salmonella infection_Homo sapiens_hsa051320.79287843
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76609551
64Small cell lung cancer_Homo sapiens_hsa052220.76554678
65Autoimmune thyroid disease_Homo sapiens_hsa053200.76008986
66Viral carcinogenesis_Homo sapiens_hsa052030.74441075
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71945526
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.71851399
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70623745
70Non-homologous end-joining_Homo sapiens_hsa034500.67119745
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.66101510
72Notch signaling pathway_Homo sapiens_hsa043300.65095802
73HTLV-I infection_Homo sapiens_hsa051660.64208394
74p53 signaling pathway_Homo sapiens_hsa041150.60293867
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.58248619
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.57423574
77Rheumatoid arthritis_Homo sapiens_hsa053230.56711936
78Homologous recombination_Homo sapiens_hsa034400.56012664
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.54784506
80Lysosome_Homo sapiens_hsa041420.54189847
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53350058
82Arachidonic acid metabolism_Homo sapiens_hsa005900.52671494
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52224097
84Sulfur relay system_Homo sapiens_hsa041220.51532068
85Insulin resistance_Homo sapiens_hsa049310.50280717
86Amoebiasis_Homo sapiens_hsa051460.50091345
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48541568
88Endocytosis_Homo sapiens_hsa041440.46397140
89Choline metabolism in cancer_Homo sapiens_hsa052310.45161333
90HIF-1 signaling pathway_Homo sapiens_hsa040660.44347266
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43195254
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42550436
93Non-small cell lung cancer_Homo sapiens_hsa052230.41592780
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41432846
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.40289531
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39891345
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38154990
98Renin-angiotensin system_Homo sapiens_hsa046140.38027525
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35256796
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33673194
101VEGF signaling pathway_Homo sapiens_hsa043700.33454956
102GnRH signaling pathway_Homo sapiens_hsa049120.32715648
103Inositol phosphate metabolism_Homo sapiens_hsa005620.31324473
104Pyrimidine metabolism_Homo sapiens_hsa002400.31268308
105Systemic lupus erythematosus_Homo sapiens_hsa053220.30647001
106mTOR signaling pathway_Homo sapiens_hsa041500.29835549
107Type I diabetes mellitus_Homo sapiens_hsa049400.29573077
108Complement and coagulation cascades_Homo sapiens_hsa046100.27672703
109N-Glycan biosynthesis_Homo sapiens_hsa005100.26997106
110FoxO signaling pathway_Homo sapiens_hsa040680.26839703
111Glycerolipid metabolism_Homo sapiens_hsa005610.26693255
112Nucleotide excision repair_Homo sapiens_hsa034200.25086391
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24696569
114MAPK signaling pathway_Homo sapiens_hsa040100.24068085
115Pentose phosphate pathway_Homo sapiens_hsa000300.23934980
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23559073
117RNA degradation_Homo sapiens_hsa030180.22892183
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22726750
119Dorso-ventral axis formation_Homo sapiens_hsa043200.21901700
120Renal cell carcinoma_Homo sapiens_hsa052110.21293285
121Lysine degradation_Homo sapiens_hsa003100.21168318
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21084570
123Cyanoamino acid metabolism_Homo sapiens_hsa004600.20665622
124Spliceosome_Homo sapiens_hsa030400.20269304
125Linoleic acid metabolism_Homo sapiens_hsa005910.18549385
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.16726755

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