UBALD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)5.41513971
2translational termination (GO:0006415)5.18390665
3positive regulation of gamma-delta T cell activation (GO:0046645)5.18198099
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.17099893
5negative regulation of cell killing (GO:0031342)5.17099893
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.12951891
7positive regulation by symbiont of host defense response (GO:0052509)5.00657933
8modulation by symbiont of host defense response (GO:0052031)5.00657933
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.00657933
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.00657933
11positive regulation by organism of defense response of other organism involved in symbiotic interact5.00657933
12modulation by symbiont of host immune response (GO:0052553)5.00657933
13antigen processing and presentation of endogenous antigen (GO:0019883)4.92511053
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.87650237
15ribosomal small subunit assembly (GO:0000028)4.85241686
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.66886249
17ribosomal small subunit biogenesis (GO:0042274)4.57311299
18translational elongation (GO:0006414)4.55832690
19response to peptidoglycan (GO:0032494)4.48091924
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.38349947
21negative regulation of erythrocyte differentiation (GO:0045647)4.35599760
22detection of bacterium (GO:0016045)4.30809524
23maturation of SSU-rRNA (GO:0030490)4.28325646
24detection of other organism (GO:0098543)4.27421000
25translational initiation (GO:0006413)4.19626479
26regulation of B cell receptor signaling pathway (GO:0050855)4.15321989
27viral life cycle (GO:0019058)4.13521333
28macrophage activation involved in immune response (GO:0002281)4.09339885
29cellular protein complex disassembly (GO:0043624)4.03096633
30DNA unwinding involved in DNA replication (GO:0006268)4.02959794
31protein localization to kinetochore (GO:0034501)4.01644582
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.01229970
33immunoglobulin mediated immune response (GO:0016064)4.00698907
34leukocyte aggregation (GO:0070486)3.99804173
35NIK/NF-kappaB signaling (GO:0038061)3.94257368
36negative regulation of interleukin-12 production (GO:0032695)3.93889895
37response to muramyl dipeptide (GO:0032495)3.92230106
38protein targeting to ER (GO:0045047)3.91679715
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.88502349
40neutrophil activation involved in immune response (GO:0002283)3.88348073
41cotranslational protein targeting to membrane (GO:0006613)3.88148303
42tolerance induction (GO:0002507)3.82909487
43regulation of gamma-delta T cell activation (GO:0046643)3.78704181
44protein complex disassembly (GO:0043241)3.77585182
45cellular response to type I interferon (GO:0071357)3.73780505
46type I interferon signaling pathway (GO:0060337)3.73780505
47establishment of protein localization to endoplasmic reticulum (GO:0072599)3.71798306
48response to type I interferon (GO:0034340)3.71247807
49ribosomal large subunit biogenesis (GO:0042273)3.68390431
50regulation of gene silencing by miRNA (GO:0060964)3.65377430
51regulation of gene silencing by RNA (GO:0060966)3.65377430
52regulation of posttranscriptional gene silencing (GO:0060147)3.65377430
53positive thymic T cell selection (GO:0045059)3.65065638
54protein localization to chromosome, centromeric region (GO:0071459)3.61701577
55protein localization to endoplasmic reticulum (GO:0070972)3.58133455
56germinal center formation (GO:0002467)3.57616836
57positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.56477734
58B cell receptor signaling pathway (GO:0050853)3.52610189
59heterochromatin organization (GO:0070828)3.51340172
60regulation of interferon-beta biosynthetic process (GO:0045357)3.51057698
61myeloid dendritic cell differentiation (GO:0043011)3.46576559
62macromolecular complex disassembly (GO:0032984)3.45838002
63trophectodermal cell differentiation (GO:0001829)3.44840378
64detection of external biotic stimulus (GO:0098581)3.44824894
65folic acid-containing compound biosynthetic process (GO:0009396)3.41845329
66dosage compensation (GO:0007549)3.41478088
67formation of translation preinitiation complex (GO:0001731)3.39131237
68response to host immune response (GO:0052572)3.37095592
69response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.37095592
70negative regulation of lymphocyte mediated immunity (GO:0002707)3.35783920
71cellular extravasation (GO:0045123)3.35758214
72regulation of translational fidelity (GO:0006450)3.34910332
73response to interleukin-15 (GO:0070672)3.31789618
74defense response to protozoan (GO:0042832)3.30826075
75interferon-gamma-mediated signaling pathway (GO:0060333)3.29267022
76negative thymic T cell selection (GO:0045060)3.24844161
77nuclear-transcribed mRNA catabolic process (GO:0000956)3.24533049
78thymic T cell selection (GO:0045061)3.22992449
79T cell migration (GO:0072678)3.22788024
80DNA strand elongation involved in DNA replication (GO:0006271)3.22681558
81lipopolysaccharide-mediated signaling pathway (GO:0031663)3.22567163
82positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.22044583
83response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.21513466
84response to host (GO:0075136)3.21513466
85response to host defenses (GO:0052200)3.21513466
86positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.19510452
87respiratory burst (GO:0045730)3.19402616
88myeloid dendritic cell activation (GO:0001773)3.19188557
89response to protozoan (GO:0001562)3.18367998
90negative regulation of leukocyte mediated immunity (GO:0002704)3.17280939
91DNA replication initiation (GO:0006270)3.17143412
92mitotic sister chromatid segregation (GO:0000070)3.17109591
93negative regulation of T cell mediated immunity (GO:0002710)3.16137363
94regulation of histone H3-K9 methylation (GO:0051570)3.12881649
95mitotic nuclear envelope disassembly (GO:0007077)3.12721487
96positive regulation of B cell differentiation (GO:0045579)3.10538673
97negative regulation of histone methylation (GO:0031061)3.10157328
98mRNA catabolic process (GO:0006402)3.09504496
99negative T cell selection (GO:0043383)3.07907556
1003-UTR-mediated mRNA stabilization (GO:0070935)3.06853844
101RNA catabolic process (GO:0006401)3.06772707
102ribonucleoprotein complex biogenesis (GO:0022613)3.06722550
103T cell selection (GO:0045058)3.06213760
104regulation of dendritic cell antigen processing and presentation (GO:0002604)3.06025481
105DNA strand elongation (GO:0022616)3.03906282
106detection of biotic stimulus (GO:0009595)3.02743460
107B cell mediated immunity (GO:0019724)3.02614161
108sister chromatid segregation (GO:0000819)3.02340991
109regulation of T cell tolerance induction (GO:0002664)3.02283578
110positive T cell selection (GO:0043368)3.01919426
111negative regulation of cytokine production involved in immune response (GO:0002719)3.01490262
112myeloid cell activation involved in immune response (GO:0002275)3.01270590
113T-helper 1 type immune response (GO:0042088)2.99165352
114DNA replication-dependent nucleosome organization (GO:0034723)2.99023830
115DNA replication-dependent nucleosome assembly (GO:0006335)2.99023830
116cellular response to interleukin-15 (GO:0071350)2.98478654
117B cell homeostasis (GO:0001782)2.96394592
118embryonic process involved in female pregnancy (GO:0060136)2.96391609
119regulation of mast cell degranulation (GO:0043304)2.95553666
120neutrophil activation (GO:0042119)2.95418137
121negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.93578444
122detection of molecule of bacterial origin (GO:0032490)2.93457538
123granulocyte activation (GO:0036230)2.92896002
124modulation by symbiont of host cellular process (GO:0044068)2.92843826
125mitotic chromosome condensation (GO:0007076)2.92039712
126negative regulation of RNA splicing (GO:0033119)2.90064333
127CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.90019322
128membrane disassembly (GO:0030397)2.89614816
129nuclear envelope disassembly (GO:0051081)2.89614816
130regulation of B cell differentiation (GO:0045577)2.89218481
131regulation of alpha-beta T cell proliferation (GO:0046640)2.87699165
132nuclear pore organization (GO:0006999)2.86346610
133telomere maintenance via semi-conservative replication (GO:0032201)2.85511445
134negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.84750790
135chromatin assembly (GO:0031497)2.84546897
136positive regulation of SMAD protein import into nucleus (GO:0060391)2.83967399
137negative regulation of phagocytosis (GO:0050765)2.83155962
138modulation by virus of host process (GO:0019054)2.82860749
139regulation of tolerance induction (GO:0002643)2.82611480
140negative regulation of innate immune response (GO:0045824)2.81811066
141DNA duplex unwinding (GO:0032508)2.79989401
142ncRNA 3-end processing (GO:0043628)2.79944931
143interferon-gamma secretion (GO:0072643)2.79812536
144regulation of interleukin-2 biosynthetic process (GO:0045076)2.79799814
145regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.78836210
146DNA geometric change (GO:0032392)2.78068826
147negative regulation of interleukin-6 production (GO:0032715)2.77294389
148regulation of T-helper 2 cell differentiation (GO:0045628)2.76963983
149regulation of natural killer cell mediated immunity (GO:0002715)2.75425929
150regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.75425929
151regulation of type I interferon-mediated signaling pathway (GO:0060338)2.74332620
152protein localization to chromosome (GO:0034502)2.74078381
153establishment of apical/basal cell polarity (GO:0035089)2.73166296
154RNA stabilization (GO:0043489)2.72900210
155mRNA stabilization (GO:0048255)2.72900210
156lymphocyte homeostasis (GO:0002260)2.72632309
157apoptotic process involved in morphogenesis (GO:0060561)2.72209774
158negative regulation of toll-like receptor signaling pathway (GO:0034122)2.70833503
159regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.69404312
160maternal placenta development (GO:0001893)2.69365027
161positive regulation of interferon-alpha production (GO:0032727)2.69306839
162regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.69254809
163regulation of leukocyte degranulation (GO:0043300)2.68869184
164macrophage activation (GO:0042116)2.68605438
165regulation of gamma-delta T cell differentiation (GO:0045586)2.68487233
166nuclear pore complex assembly (GO:0051292)2.68022664
167DNA deamination (GO:0045006)2.67580940
168IMP biosynthetic process (GO:0006188)2.67154579
169positive regulation of chromosome segregation (GO:0051984)2.67126226
170regulation of antigen processing and presentation (GO:0002577)2.67082902
171negative regulation of mRNA processing (GO:0050686)2.66218238
172mitotic metaphase plate congression (GO:0007080)2.66091630
173pre-miRNA processing (GO:0031054)2.63942541
174regulation of helicase activity (GO:0051095)2.63847573
175negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.63498843
176protein targeting to membrane (GO:0006612)2.56537898
177regulation of gene silencing (GO:0060968)2.56241759
178negative regulation of mRNA metabolic process (GO:1903312)2.55122544
179T cell apoptotic process (GO:0070231)2.54951420
180regulation of SMAD protein import into nucleus (GO:0060390)2.54394777
181regulation of hippo signaling (GO:0035330)2.51846719
182determination of adult lifespan (GO:0008340)2.50880460
183regulation of sister chromatid cohesion (GO:0007063)2.50723061
184DNA replication checkpoint (GO:0000076)2.49124901
185translation (GO:0006412)2.47607495
186DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.46610902
187nucleobase biosynthetic process (GO:0046112)2.46101077
188negative regulation of translational initiation (GO:0045947)2.45465749
189rRNA processing (GO:0006364)2.44314937
190chromatin assembly or disassembly (GO:0006333)2.42340992
191rRNA metabolic process (GO:0016072)2.40172241
192IMP metabolic process (GO:0046040)2.39825397
193regulation of telomere maintenance via telomerase (GO:0032210)2.39738604
194mitotic recombination (GO:0006312)2.38721037
195metaphase plate congression (GO:0051310)2.38637304
196nuclear envelope organization (GO:0006998)2.38468661
197telomere maintenance via recombination (GO:0000722)2.38336066
198regulation of translational termination (GO:0006449)2.37744522

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.62345115
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.22306643
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.90846201
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.18604586
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.04760882
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.00946721
7MYC_22102868_ChIP-Seq_BL_Human2.80689280
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.70151239
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.68092110
10* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.62670571
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.61281818
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.59523561
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55025742
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.49606525
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42759844
16E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.30027041
17LXR_22292898_ChIP-Seq_THP-1_Human2.23568752
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.23347028
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21049717
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17037584
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.12996805
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.09473832
23SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.09125129
24VDR_21846776_ChIP-Seq_THP-1_Human2.07013476
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.04647591
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.04000870
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.04000870
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.04000870
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02415456
30IRF8_27001747_Chip-Seq_BMDM_Mouse2.01370285
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99641195
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.97523096
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.95140414
34SPI1_23547873_ChIP-Seq_NB4_Human1.91357659
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.87284012
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.86820305
37XRN2_22483619_ChIP-Seq_HELA_Human1.85321967
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84382772
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83361776
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.79510019
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.74837940
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74311115
43RUNX_20019798_ChIP-Seq_JUKART_Human1.72808792
44SPI1_23127762_ChIP-Seq_K562_Human1.71722663
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71524662
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.71443813
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.68053234
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65045691
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61927703
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.59690225
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.56803618
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56291891
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55555769
54TCF7_22412390_ChIP-Seq_EML_Mouse1.47328574
55ZNF263_19887448_ChIP-Seq_K562_Human1.47293134
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43384842
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.41716946
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40388393
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.39772158
60MAF_26560356_Chip-Seq_TH1_Human1.38570416
61CIITA_25753668_ChIP-Seq_RAJI_Human1.37773333
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37052338
63CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37034292
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36961422
65AR_21909140_ChIP-Seq_LNCAP_Human1.35905763
66TCF3_18692474_ChIP-Seq_MEFs_Mouse1.34654384
67PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34314102
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32171971
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.31635403
70UTX_26944678_Chip-Seq_JUKART_Human1.31400542
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.31393184
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30791682
73PU.1_20513432_ChIP-Seq_Bcells_Mouse1.29660851
74E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29534522
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.29479518
76BCL6_27268052_Chip-Seq_Bcells_Human1.29399499
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.29035528
78CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28328137
79VDR_23849224_ChIP-Seq_CD4+_Human1.28073231
80BCOR_27268052_Chip-Seq_Bcells_Human1.27490151
81TTF2_22483619_ChIP-Seq_HELA_Human1.26990991
82GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26028414
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25759458
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25437500
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25420805
86CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25295953
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.24676174
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.22630076
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22247667
90MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22204504
91KDM2B_26808549_Chip-Seq_K562_Human1.22106542
92P68_20966046_ChIP-Seq_HELA_Human1.21860734
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21480430
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21262340
95SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20241037
96DCP1A_22483619_ChIP-Seq_HELA_Human1.19606157
97KDM2B_26808549_Chip-Seq_DND41_Human1.19315460
98RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19311671
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18901183
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17404782
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17373030
102KDM5A_27292631_Chip-Seq_BREAST_Human1.17139890
103NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16500578
104GATA1_19941826_ChIP-Seq_K562_Human1.15592757
105KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15461001
106SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15264130
107PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15157439
108SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14639228
109NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13920681
110ATF3_27146783_Chip-Seq_COLON_Human1.13723898
111FOXP3_21729870_ChIP-Seq_TREG_Human1.13300135
112SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13045250
113MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12500071
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12416659
115LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12308088
116ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12254178
117POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12094460
118HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11535967
119SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10279605
120NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.10018438
121KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09312403
122HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08529863
123ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08439095
124OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06945227
125GATA3_27048872_Chip-Seq_THYMUS_Human1.06194394
126TET1_21451524_ChIP-Seq_MESCs_Mouse1.05182501
127MAF_26560356_Chip-Seq_TH2_Human1.05111792
128BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04886509
129TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03780872
130GABP_19822575_ChIP-Seq_HepG2_Human1.03278063
131FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03069618
132RUNX1_22412390_ChIP-Seq_EML_Mouse1.02727787
133TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02482332
134MYB_26560356_Chip-Seq_TH2_Human1.02321146
135SOX2_18692474_ChIP-Seq_MEFs_Mouse1.02185414
136JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02149961
137CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01718592
138VDR_24763502_ChIP-Seq_THP-1_Human1.01555976
139GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00656857
140NCOR1_26117541_ChIP-Seq_K562_Human1.00305168
141MYB_26560356_Chip-Seq_TH1_Human1.00244615
142TFEB_21752829_ChIP-Seq_HELA_Human1.00085497
143TP63_19390658_ChIP-ChIP_HaCaT_Human1.00077385
144NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99988474
145SCL_19346495_ChIP-Seq_HPC-7_Human0.99067919
146KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98979700
147NANOG_21062744_ChIP-ChIP_HESCs_Human0.98757355
148RACK7_27058665_Chip-Seq_MCF-7_Human0.98058685
149SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97667139
150TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97554182
151KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97255698
152SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97119807
153TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97042010
154ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96786468
155TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96435539
156SMC4_20622854_ChIP-Seq_HELA_Human0.94472976
157PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94038556
158EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93973900
159CTCF_26484167_Chip-Seq_Bcells_Mouse0.93754427
160CREB1_26743006_Chip-Seq_LNCaP_Human0.92156428
161PU_27001747_Chip-Seq_BMDM_Mouse0.91463699
162VDR_24787735_ChIP-Seq_THP-1_Human0.90523348
163CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90066148
164CTCF_21964334_ChIP-Seq_BJAB-B_Human0.89934325

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.54790934
2MP0001835_abnormal_antigen_presentation3.36730286
3MP0004957_abnormal_blastocyst_morpholog3.21319554
4MP0003724_increased_susceptibility_to3.14906307
5MP0010352_gastrointestinal_tract_polyps3.10853475
6MP0005671_abnormal_response_to3.06480811
7MP0003111_abnormal_nucleus_morphology2.88103927
8MP0002419_abnormal_innate_immunity2.66461689
9MP0003077_abnormal_cell_cycle2.66069064
10MP0009785_altered_susceptibility_to2.66028206
11MP0010094_abnormal_chromosome_stability2.59249014
12MP0002148_abnormal_hypersensitivity_rea2.43718108
13MP0005451_abnormal_body_composition2.35231384
14MP0008057_abnormal_DNA_replication2.30924396
15MP0004510_myositis2.21228485
16MP0005076_abnormal_cell_differentiation2.19753019
17MP0000490_abnormal_crypts_of2.15073356
18MP0003705_abnormal_hypodermis_morpholog2.14921459
19MP0010234_abnormal_vibrissa_follicle2.08288678
20MP0006082_CNS_inflammation2.01615075
21MP0003300_gastrointestinal_ulcer1.96314305
22MP0003763_abnormal_thymus_physiology1.91367148
23MP0001730_embryonic_growth_arrest1.88148856
24MP0009278_abnormal_bone_marrow1.86413793
25MP0001533_abnormal_skeleton_physiology1.85460050
26MP0000350_abnormal_cell_proliferation1.84748330
27MP0005464_abnormal_platelet_physiology1.78336997
28MP0008260_abnormal_autophagy1.77799309
29MP0010307_abnormal_tumor_latency1.77551870
30MP0001845_abnormal_inflammatory_respons1.72096777
31MP0008007_abnormal_cellular_replicative1.67274639
32MP0005058_abnormal_lysosome_morphology1.61592595
33MP0003191_abnormal_cellular_cholesterol1.60731656
34MP0002086_abnormal_extraembryonic_tissu1.56484709
35MP0002396_abnormal_hematopoietic_system1.56353404
36MP0003566_abnormal_cell_adhesion1.55518050
37MP0009333_abnormal_splenocyte_physiolog1.54567930
38MP0005310_abnormal_salivary_gland1.54349207
39MP0005501_abnormal_skin_physiology1.52074271
40MP0003453_abnormal_keratinocyte_physiol1.51348493
41MP0005397_hematopoietic_system_phenotyp1.49840240
42MP0001545_abnormal_hematopoietic_system1.49840240
43MP0010155_abnormal_intestine_physiology1.49345262
44MP0000685_abnormal_immune_system1.49068075
45MP0001853_heart_inflammation1.45950787
46MP0001697_abnormal_embryo_size1.45451393
47MP0002138_abnormal_hepatobiliary_system1.44609160
48MP0005380_embryogenesis_phenotype1.44227074
49MP0001672_abnormal_embryogenesis/_devel1.44227074
50MP0003172_abnormal_lysosome_physiology1.41529961
51MP0004264_abnormal_extraembryonic_tissu1.40684172
52MP0000703_abnormal_thymus_morphology1.39829930
53MP0002398_abnormal_bone_marrow1.38651217
54MP0002084_abnormal_developmental_patter1.37532507
55MP0004197_abnormal_fetal_growth/weight/1.37351238
56MP0002085_abnormal_embryonic_tissue1.37129876
57MP0008469_abnormal_protein_level1.37050451
58MP0001849_ear_inflammation1.36570119
59MP0002019_abnormal_tumor_incidence1.35956246
60MP0008932_abnormal_embryonic_tissue1.35490337
61MP0002088_abnormal_embryonic_growth/wei1.35431716
62MP0004808_abnormal_hematopoietic_stem1.35425955
63MP0003866_abnormal_defecation1.35324591
64MP0002796_impaired_skin_barrier1.35207805
65MP0003984_embryonic_growth_retardation1.34749789
66MP0008058_abnormal_DNA_repair1.34581301
67MP0003303_peritoneal_inflammation1.32843991
68MP0002080_prenatal_lethality1.31425302
69MP0002722_abnormal_immune_system1.31269376
70MP0003567_abnormal_fetal_cardiomyocyte1.31094464
71MP0009764_decreased_sensitivity_to1.28379563
72MP0000537_abnormal_urethra_morphology1.27728571
73MP0002653_abnormal_ependyma_morphology1.26171137
74MP0003436_decreased_susceptibility_to1.26024789
75MP0002998_abnormal_bone_remodeling1.25624290
76MP0000858_altered_metastatic_potential1.24527540
77MP0000477_abnormal_intestine_morphology1.22806761
78MP0002166_altered_tumor_susceptibility1.20889257
79MP0001851_eye_inflammation1.20712552
80MP0003183_abnormal_peptide_metabolism1.20642298
81MP0000689_abnormal_spleen_morphology1.20422355
82MP0000313_abnormal_cell_death1.18388843
83MP0002405_respiratory_system_inflammati1.17604105
84MP0005023_abnormal_wound_healing1.17112557
85MP0002132_abnormal_respiratory_system1.17057094
86MP0004947_skin_inflammation1.16769492
87MP0001800_abnormal_humoral_immune1.14748650
88MP0002277_abnormal_respiratory_mucosa1.12578496
89MP0009053_abnormal_anal_canal1.11148643
90MP0003075_altered_response_to1.11095056
91MP0003119_abnormal_digestive_system1.07628307
92MP0002429_abnormal_blood_cell1.07577891
93MP0000343_altered_response_to1.07275464
94MP0003786_premature_aging1.06536212
95MP0001663_abnormal_digestive_system1.04774049
96MP0001216_abnormal_epidermal_layer1.04245120
97MP0004381_abnormal_hair_follicle1.04080517
98MP0002006_tumorigenesis1.02512661
99MP0000716_abnormal_immune_system1.01394423
100MP0005166_decreased_susceptibility_to1.00907468
101MP0004185_abnormal_adipocyte_glucose0.99686381
102MP0001873_stomach_inflammation0.99192231
103MP0003656_abnormal_erythrocyte_physiolo0.97954281
104MP0002009_preneoplasia0.97300045
105MP0000465_gastrointestinal_hemorrhage0.95793040
106MP0002420_abnormal_adaptive_immunity0.94651687
107MP0003941_abnormal_skin_development0.94425645
108MP0001819_abnormal_immune_cell0.93822483
109MP0002877_abnormal_melanocyte_morpholog0.92403877
110MP0002452_abnormal_antigen_presenting0.90388998
111MP0002933_joint_inflammation0.90308011
112MP0003448_altered_tumor_morphology0.88300421
113MP0010030_abnormal_orbit_morphology0.88278149
114MP0003091_abnormal_cell_migration0.87357056
115MP0001790_abnormal_immune_system0.87115507
116MP0005387_immune_system_phenotype0.87115507
117MP0002098_abnormal_vibrissa_morphology0.85532249
118MP0003123_paternal_imprinting0.85445257
119MP0009931_abnormal_skin_appearance0.85114048
120MP0000604_amyloidosis0.84129656
121MP0005390_skeleton_phenotype0.83595168
122MP0002723_abnormal_immune_serum0.83320025
123MP0003806_abnormal_nucleotide_metabolis0.82762625
124MP0000377_abnormal_hair_follicle0.79625291
125MP0000733_abnormal_muscle_development0.78064596
126MP0005025_abnormal_response_to0.76656089
127MP0009840_abnormal_foam_cell0.76487462
128MP0001915_intracranial_hemorrhage0.75680012
129MP0005000_abnormal_immune_tolerance0.75628333
130MP0009763_increased_sensitivity_to0.75253572
131MP0004883_abnormal_blood_vessel0.75147112
132MP0001293_anophthalmia0.74596116
133MP0003045_fibrosis0.74356309
134MP0002925_abnormal_cardiovascular_devel0.74012959
135MP0002060_abnormal_skin_morphology0.73676721
136MP0008004_abnormal_stomach_pH0.70748220
137MP0000467_abnormal_esophagus_morphology0.69192332
138MP0002111_abnormal_tail_morphology0.68607882
139MP0009765_abnormal_xenobiotic_induced0.67724004
140MP0005666_abnormal_adipose_tissue0.67678485
141MP0003828_pulmonary_edema0.67260814
142MP0000249_abnormal_blood_vessel0.66720200
143MP0005381_digestive/alimentary_phenotyp0.65340708
144MP0005164_abnormal_response_to0.64434746
145MP0001348_abnormal_lacrimal_gland0.62077267
146MP0008874_decreased_physiological_sensi0.61409611
147MP0003795_abnormal_bone_structure0.60675818
148MP0004858_abnormal_nervous_system0.60639819
149MP0000678_abnormal_parathyroid_gland0.57174489
150MP0000609_abnormal_liver_physiology0.53639251
151MP0009115_abnormal_fat_cell0.49301216
152MP0002693_abnormal_pancreas_physiology0.48043531

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.94218191
2Recurrent bacterial skin infections (HP:0005406)4.91482530
3Recurrent abscess formation (HP:0002722)4.80585391
4Abnormality of macrophages (HP:0004311)4.68490944
5Reticulocytopenia (HP:0001896)4.65974697
6Myositis (HP:0100614)4.45066900
7Abnormality of cells of the erythroid lineage (HP:0012130)4.31143237
8Orchitis (HP:0100796)4.11758757
9Mediastinal lymphadenopathy (HP:0100721)4.08208930
10Meningitis (HP:0001287)4.07745683
11Obstructive lung disease (HP:0006536)3.98272213
12Chronic obstructive pulmonary disease (HP:0006510)3.98272213
13Elevated erythrocyte sedimentation rate (HP:0003565)3.97986577
14Gastrointestinal stroma tumor (HP:0100723)3.92541660
15Retrobulbar optic neuritis (HP:0100654)3.81379883
16Optic neuritis (HP:0100653)3.81379883
17Stomatitis (HP:0010280)3.76744099
18Abnormal number of erythroid precursors (HP:0012131)3.75542936
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.73843495
20Vasculitis (HP:0002633)3.73751597
21Recurrent gram-negative bacterial infections (HP:0005420)3.62280997
22Ependymoma (HP:0002888)3.46312757
23Gastrointestinal infarctions (HP:0005244)3.43378452
24Recurrent skin infections (HP:0001581)3.28484656
25Urticaria (HP:0001025)3.23971479
26Spontaneous hematomas (HP:0007420)3.18583543
27Encephalitis (HP:0002383)3.14367338
28Lymphopenia (HP:0001888)3.09970861
29Basal cell carcinoma (HP:0002671)3.09863383
30Macrocytic anemia (HP:0001972)3.03912761
31Agammaglobulinemia (HP:0004432)3.03474054
32Recurrent cutaneous fungal infections (HP:0011370)2.96887086
33Chronic mucocutaneous candidiasis (HP:0002728)2.96887086
34Abnormality of cells of the lymphoid lineage (HP:0012140)2.94178426
35Increased IgM level (HP:0003496)2.92925111
36Pallor (HP:0000980)2.90449780
37Abnormality of reticulocytes (HP:0004312)2.90109206
38Panhypogammaglobulinemia (HP:0003139)2.85696026
39Colitis (HP:0002583)2.83955391
40Selective tooth agenesis (HP:0001592)2.80145125
41Gingivitis (HP:0000230)2.77120560
42Pulmonary infiltrates (HP:0002113)2.73973953
43Prolonged bleeding time (HP:0003010)2.73490403
44Keratoconjunctivitis sicca (HP:0001097)2.71372840
45Multiple enchondromatosis (HP:0005701)2.67081978
46Emphysema (HP:0002097)2.67042609
47Recurrent sinusitis (HP:0011108)2.66823344
48Pustule (HP:0200039)2.63575750
49Trismus (HP:0000211)2.60861671
50Proximal placement of thumb (HP:0009623)2.60708382
51Absent thumb (HP:0009777)2.57421679
52Hypochromic microcytic anemia (HP:0004840)2.56816045
53Abnormality of T cell physiology (HP:0011840)2.55815001
54Chest pain (HP:0100749)2.53767433
55Purpura (HP:0000979)2.53530624
56Osteomyelitis (HP:0002754)2.51504875
57Colon cancer (HP:0003003)2.49502432
58Deviation of the thumb (HP:0009603)2.49404692
59Restrictive lung disease (HP:0002091)2.47052194
60IgM deficiency (HP:0002850)2.45911955
61Biliary tract neoplasm (HP:0100574)2.45888833
62Hemoptysis (HP:0002105)2.44099253
63Hypergammaglobulinemia (HP:0010702)2.42936663
64Breast hypoplasia (HP:0003187)2.42883205
65Recurrent bronchitis (HP:0002837)2.42744838
66Keratoconjunctivitis (HP:0001096)2.38239899
67Hypertensive crisis (HP:0100735)2.37395633
68Abnormality of liposaccharide metabolism (HP:0010968)2.32949118
69Abnormality of glycosphingolipid metabolism (HP:0004343)2.32949118
70Abnormality of glycolipid metabolism (HP:0010969)2.32949118
71Missing ribs (HP:0000921)2.32908810
72Segmental peripheral demyelination/remyelination (HP:0003481)2.32661830
73Epistaxis (HP:0000421)2.31040346
74Sepsis (HP:0100806)2.30551479
75Granulocytopenia (HP:0001913)2.29466311
76Patellar aplasia (HP:0006443)2.27471740
77Thrombocytosis (HP:0001894)2.26619367
78Medulloblastoma (HP:0002885)2.26042073
79Rhabdomyosarcoma (HP:0002859)2.25497425
80Oral leukoplakia (HP:0002745)2.16622102
81Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.16423864
82Rib fusion (HP:0000902)2.16383116
83Autoimmune hemolytic anemia (HP:0001890)2.16313983
84Esophageal atresia (HP:0002032)2.14859066
85Pili torti (HP:0003777)2.14714784
86Arterial thrombosis (HP:0004420)2.14518901
87Increased serum ferritin (HP:0003281)2.14442260
88Abnormal number of incisors (HP:0011064)2.14344096
89Microcytic anemia (HP:0001935)2.14081154
90Autoimmune thrombocytopenia (HP:0001973)2.12416326
91Angiofibromas (HP:0010615)2.11995131
92Adenoma sebaceum (HP:0009720)2.11995131
93Abnormality of T cell number (HP:0011839)2.11433828
94Absent radius (HP:0003974)2.11354210
95Malignant gastrointestinal tract tumors (HP:0006749)2.11194866
96Gastrointestinal carcinoma (HP:0002672)2.11194866
97Aplasia/Hypoplasia of the patella (HP:0006498)2.10781298
98Neoplasm of the pancreas (HP:0002894)2.10656343
99Astrocytoma (HP:0009592)2.08824725
100Abnormality of the astrocytes (HP:0100707)2.08824725
101Abnormal hemoglobin (HP:0011902)2.08139196
102Anorexia (HP:0002039)2.07643635
103Polygenic inheritance (HP:0010982)2.07457907
104Leukocytosis (HP:0001974)2.07016677
105Pulmonary embolism (HP:0002204)2.06896287
106Recurrent pneumonia (HP:0006532)2.06510516
107Recurrent lower respiratory tract infections (HP:0002783)2.05640389
108Vertebral clefting (HP:0008428)2.05535108
109Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04577724
110Increased density of long bones (HP:0006392)2.04336615
111Episodic fever (HP:0001954)2.04183862
112Skin ulcer (HP:0200042)2.03509137
113Abnormality of the pleura (HP:0002103)2.03340961
114Nasal polyposis (HP:0100582)2.03190627
115Combined immunodeficiency (HP:0005387)2.03005893
116Poikiloderma (HP:0001029)2.01022497
117Skin rash (HP:0000988)2.00294577
118Gangrene (HP:0100758)1.99655342
119Viral hepatitis (HP:0006562)1.99316305
120Rectal prolapse (HP:0002035)1.99165026
121Abnormality of the fingertips (HP:0001211)1.98061669
122Premature loss of primary teeth (HP:0006323)1.97770796
123Absent forearm bone (HP:0003953)1.97393918
124Aplasia involving forearm bones (HP:0009822)1.97393918
125Carpal bone hypoplasia (HP:0001498)1.96396832
126Woolly hair (HP:0002224)1.95923504
127Arthralgia (HP:0002829)1.95518777
128Slow saccadic eye movements (HP:0000514)1.93872910
129Abnormality of the peritoneum (HP:0002585)1.92791370
130Polycythemia (HP:0001901)1.92596183
131Neoplasm of striated muscle (HP:0009728)1.92552269
132Atresia of the external auditory canal (HP:0000413)1.92142454
133Agnosia (HP:0010524)1.91962416
134Birth length less than 3rd percentile (HP:0003561)1.91587591
135Abnormality of the nasal mucosa (HP:0000433)1.91226297
136Reticulocytosis (HP:0001923)1.91184868
137Hepatosplenomegaly (HP:0001433)1.91056711
138Interstitial pulmonary disease (HP:0006530)1.90572054
139Hypochromic anemia (HP:0001931)1.89319288
140Amaurosis fugax (HP:0100576)1.88169592
141Increased cerebral lipofuscin (HP:0011813)1.87730206
142Gingival bleeding (HP:0000225)1.87232250
14311 pairs of ribs (HP:0000878)1.87125830
144Squamous cell carcinoma (HP:0002860)1.86703914
145Aplasia/hypoplasia of the humerus (HP:0006507)1.82671609
146Increased IgE level (HP:0003212)1.81412906
147Abnormality of T cells (HP:0002843)1.81342930
148Gastrointestinal inflammation (HP:0004386)1.79543345
149Lymphoma (HP:0002665)1.78863662
150Increased nuchal translucency (HP:0010880)1.78278876
151Neoplasm of the oral cavity (HP:0100649)1.77733753
152Degeneration of anterior horn cells (HP:0002398)1.77522038
153Abnormality of the anterior horn cell (HP:0006802)1.77522038
154Chromsome breakage (HP:0040012)1.77324641
155Blepharitis (HP:0000498)1.76096302
156Papilloma (HP:0012740)1.75901721
157Verrucae (HP:0200043)1.75901721
158Skin tags (HP:0010609)1.75621931
159Myelodysplasia (HP:0002863)1.74820631
160Petechiae (HP:0000967)1.74374508
161Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.72740801
162Impulsivity (HP:0100710)1.72691450
163Supernumerary ribs (HP:0005815)1.72046391
164Asplenia (HP:0001746)1.70789950
165Prominent nose (HP:0000448)1.69753650
166Preauricular skin tag (HP:0000384)1.69492366
167T lymphocytopenia (HP:0005403)1.68995051
168Recurrent fungal infections (HP:0002841)1.68669106
169Pseudobulbar signs (HP:0002200)1.66869373
170Volvulus (HP:0002580)1.66316616
171Overlapping toe (HP:0001845)1.66097364
172Premature ovarian failure (HP:0008209)1.65393805
173Ulnar bowing (HP:0003031)1.65380989
174Abnormal hair laboratory examination (HP:0003328)1.65316039
175Short humerus (HP:0005792)1.65227685
176Cellulitis (HP:0100658)1.64950327
177Inflammation of the large intestine (HP:0002037)1.64727147
178Aplasia/Hypoplasia of the spleen (HP:0010451)1.64716149
179Recurrent viral infections (HP:0004429)1.64149752
180Uterine neoplasm (HP:0010784)1.63254869
181Tracheoesophageal fistula (HP:0002575)1.63218059
182Stenosis of the external auditory canal (HP:0000402)1.63202094
183Supernumerary bones of the axial skeleton (HP:0009144)1.63002219

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.88355111
2RIPK43.84668628
3EEF2K3.49215911
4MAP3K103.17610569
5IRAK43.09246418
6CDK123.05245776
7MAP4K12.63028726
8NEK22.60580607
9PKN22.60505218
10STK102.47860674
11RPS6KB22.43633643
12EPHA22.31794617
13TRIB32.18315512
14WEE12.13980944
15CDC72.09161671
16SMG12.05963244
17TLK12.02720116
18GRK62.02368229
19SIK31.93236700
20NME21.93173041
21SIK11.88340091
22MAP3K141.87231729
23IRAK31.86149791
24MST41.78467016
25TAOK21.75828892
26LRRK21.74614756
27SIK21.70831514
28BUB11.69022541
29IKBKE1.67254466
30CDK41.66037528
31MAP3K131.65786856
32MAP3K81.57026198
33TNK21.52400991
34FES1.50843217
35PIM11.49215519
36TTK1.48190140
37DYRK31.46417614
38MAPKAPK31.40630115
39CDK71.38421865
40SYK1.32547629
41MAP3K11.31242481
42MAP2K21.31130712
43RPS6KA41.26181494
44PAK41.23676195
45NEK11.22701827
46CDK61.22500805
47TXK1.22158073
48STK41.21627244
49ERN11.20674745
50TESK21.18590279
51AURKB1.18506682
52MAP3K111.16334227
53ICK1.15732740
54TSSK61.14752148
55PASK1.12684506
56PTK61.11056995
57HIPK21.07750750
58MARK21.06923873
59FLT31.06498399
60IRAK21.04607547
61BRD41.03088037
62PLK11.02262598
63EIF2AK11.01500988
64LYN1.00792248
65ALK0.98520275
66JAK10.95010419
67CSF1R0.94730839
68IRAK10.92878076
69FGR0.91662839
70BMX0.91138337
71PRKD20.91098278
72MAP2K30.91015347
73SCYL20.90095581
74TGFBR10.88817247
75KSR20.86950935
76CDC42BPA0.86445693
77JAK20.85661068
78LCK0.84862229
79ZAP700.83652394
80CSK0.83459679
81KIT0.82347229
82DYRK1B0.81393055
83MAPK120.81265451
84CHEK20.81138412
85AURKA0.80199442
86ITK0.79825641
87CHEK10.79333140
88ATR0.78301317
89BTK0.78248209
90FGFR40.77229031
91PDK10.75796795
92MTOR0.75613227
93PDPK10.74806569
94CLK10.72469885
95MAP3K30.71305406
96TAOK30.68104975
97ACVR1B0.67546797
98BRAF0.66017401
99DMPK0.65698011
100TYK20.64911429
101KDR0.64809728
102JAK30.64797276
103CHUK0.63727396
104RPS6KA50.63548840
105ILK0.62781652
106MAPK70.61644834
107PRKCI0.61458343
108MAP3K70.60646032
109BLK0.60441923
110MAPK110.59448716
111CDK20.59206908
112SRPK10.59175093
113TAOK10.58797729
114VRK10.58727040
115RPS6KA10.58542220
116RIPK10.58261871
117CAMKK10.56167164
118MELK0.55936632
119TEC0.54754192
120ARAF0.54467850
121MOS0.52944975
122EPHB20.52461940
123STK30.52263495
124IKBKB0.51911952
125PIM20.51299155
126EPHB10.51011958
127BRSK20.50412470
128FGFR30.50306562
129BMPR20.50014370
130PAK10.49203969
131AKT20.47870656
132TBK10.47766245
133MATK0.47612470
134TGFBR20.47295488
135ATM0.47197662
136TYRO30.45348430
137MAPKAPK20.45296946
138RPS6KL10.45082289
139RPS6KC10.45082289
140PRKCQ0.44557650
141TTN0.44516425
142SGK30.43983723
143MARK30.42014601
144RPS6KA60.41857646
145HCK0.41234107
146MAPK40.39410380
147YES10.36287182
148CDK190.34463461
149PRKCH0.32406417
150RPS6KA20.32285510
151FYN0.32108436

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.09468848
2DNA replication_Homo sapiens_hsa030303.72058333
3Mismatch repair_Homo sapiens_hsa034303.27705853
4Spliceosome_Homo sapiens_hsa030402.82288600
5Allograft rejection_Homo sapiens_hsa053302.66565673
6Graft-versus-host disease_Homo sapiens_hsa053322.44931558
7Autoimmune thyroid disease_Homo sapiens_hsa053202.43116918
8RNA transport_Homo sapiens_hsa030132.33871753
9Base excision repair_Homo sapiens_hsa034102.33702966
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.16848304
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15604519
12Cell cycle_Homo sapiens_hsa041102.15359125
13Staphylococcus aureus infection_Homo sapiens_hsa051502.12036975
14One carbon pool by folate_Homo sapiens_hsa006702.08800662
15Tuberculosis_Homo sapiens_hsa051521.85320233
16Homologous recombination_Homo sapiens_hsa034401.83908365
17Nucleotide excision repair_Homo sapiens_hsa034201.83359558
18Asthma_Homo sapiens_hsa053101.82928863
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81686786
20Type I diabetes mellitus_Homo sapiens_hsa049401.77156552
21Systemic lupus erythematosus_Homo sapiens_hsa053221.70041989
22mRNA surveillance pathway_Homo sapiens_hsa030151.67058555
23p53 signaling pathway_Homo sapiens_hsa041151.63619596
24Malaria_Homo sapiens_hsa051441.61857720
25Primary immunodeficiency_Homo sapiens_hsa053401.52782473
26Other glycan degradation_Homo sapiens_hsa005111.48812468
27Chemokine signaling pathway_Homo sapiens_hsa040621.43057677
28Viral carcinogenesis_Homo sapiens_hsa052031.40258837
29Small cell lung cancer_Homo sapiens_hsa052221.39532715
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.39510395
31Antigen processing and presentation_Homo sapiens_hsa046121.35629397
32RNA polymerase_Homo sapiens_hsa030201.35475394
33Pyrimidine metabolism_Homo sapiens_hsa002401.30534229
34Acute myeloid leukemia_Homo sapiens_hsa052211.28175865
35Chronic myeloid leukemia_Homo sapiens_hsa052201.27378483
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26694929
37Herpes simplex infection_Homo sapiens_hsa051681.25707742
38Fanconi anemia pathway_Homo sapiens_hsa034601.25440362
39Sulfur relay system_Homo sapiens_hsa041221.24145833
40Hepatitis C_Homo sapiens_hsa051601.19594592
41Rheumatoid arthritis_Homo sapiens_hsa053231.19252936
42Bladder cancer_Homo sapiens_hsa052191.16498300
43Notch signaling pathway_Homo sapiens_hsa043301.16056486
44HTLV-I infection_Homo sapiens_hsa051661.15208994
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14864986
46Epstein-Barr virus infection_Homo sapiens_hsa051691.11039542
47RNA degradation_Homo sapiens_hsa030181.10655772
48African trypanosomiasis_Homo sapiens_hsa051431.10160056
49Thyroid cancer_Homo sapiens_hsa052161.09307432
50MicroRNAs in cancer_Homo sapiens_hsa052061.05166319
51NF-kappa B signaling pathway_Homo sapiens_hsa040641.04202454
52Renal cell carcinoma_Homo sapiens_hsa052111.03696368
53Neurotrophin signaling pathway_Homo sapiens_hsa047221.03632698
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03316459
55Apoptosis_Homo sapiens_hsa042101.01771815
56Non-homologous end-joining_Homo sapiens_hsa034501.00393416
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98763604
58Salmonella infection_Homo sapiens_hsa051320.98224884
59Phagosome_Homo sapiens_hsa041450.97672943
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.97438230
61Measles_Homo sapiens_hsa051620.97335910
62Adherens junction_Homo sapiens_hsa045200.96880342
63Pentose phosphate pathway_Homo sapiens_hsa000300.94993950
64T cell receptor signaling pathway_Homo sapiens_hsa046600.93758210
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.93421281
66Pertussis_Homo sapiens_hsa051330.92418318
67Prolactin signaling pathway_Homo sapiens_hsa049170.91322356
68B cell receptor signaling pathway_Homo sapiens_hsa046620.89639906
69Colorectal cancer_Homo sapiens_hsa052100.86038761
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85927175
71Hippo signaling pathway_Homo sapiens_hsa043900.83870876
72Leishmaniasis_Homo sapiens_hsa051400.81678361
73Hepatitis B_Homo sapiens_hsa051610.80505894
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80136804
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80062625
76Toxoplasmosis_Homo sapiens_hsa051450.79645898
77Basal cell carcinoma_Homo sapiens_hsa052170.78244326
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78161069
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77258346
80Shigellosis_Homo sapiens_hsa051310.76403133
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75942111
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72751059
83Legionellosis_Homo sapiens_hsa051340.71887893
84Non-small cell lung cancer_Homo sapiens_hsa052230.71821438
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71778280
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71383496
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71229228
88Biosynthesis of amino acids_Homo sapiens_hsa012300.71013784
89Hematopoietic cell lineage_Homo sapiens_hsa046400.68842105
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.68782576
91Platelet activation_Homo sapiens_hsa046110.68639923
92FoxO signaling pathway_Homo sapiens_hsa040680.68599110
93Osteoclast differentiation_Homo sapiens_hsa043800.68589418
94mTOR signaling pathway_Homo sapiens_hsa041500.67606249
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.67488329
96Basal transcription factors_Homo sapiens_hsa030220.67066602
97Lysine degradation_Homo sapiens_hsa003100.67059642
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.65781438
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65764725
100Lysosome_Homo sapiens_hsa041420.65068221
101Endometrial cancer_Homo sapiens_hsa052130.63708470
102Selenocompound metabolism_Homo sapiens_hsa004500.63534524
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.63158080
104Prion diseases_Homo sapiens_hsa050200.62446980
105Pancreatic cancer_Homo sapiens_hsa052120.62397321
106Endocytosis_Homo sapiens_hsa041440.62329387
107Pathways in cancer_Homo sapiens_hsa052000.62146269
108Folate biosynthesis_Homo sapiens_hsa007900.61335525
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60309224
110TGF-beta signaling pathway_Homo sapiens_hsa043500.60135593
111HIF-1 signaling pathway_Homo sapiens_hsa040660.59893877
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59245721
113GnRH signaling pathway_Homo sapiens_hsa049120.58797873
114Proteasome_Homo sapiens_hsa030500.58333281
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.56921112
116VEGF signaling pathway_Homo sapiens_hsa043700.56766689
117Influenza A_Homo sapiens_hsa051640.56743521
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56483517
119MAPK signaling pathway_Homo sapiens_hsa040100.55877151
120Tight junction_Homo sapiens_hsa045300.55500955
121Viral myocarditis_Homo sapiens_hsa054160.55393105
122Prostate cancer_Homo sapiens_hsa052150.55034208
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54785417
124Proteoglycans in cancer_Homo sapiens_hsa052050.54097795
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52831352
126Glutathione metabolism_Homo sapiens_hsa004800.52769910
127Alcoholism_Homo sapiens_hsa050340.51974616
128ErbB signaling pathway_Homo sapiens_hsa040120.51904650
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50862560
130Galactose metabolism_Homo sapiens_hsa000520.50680500
131Insulin resistance_Homo sapiens_hsa049310.49743478
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.48800066
133Amoebiasis_Homo sapiens_hsa051460.48516512
134RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48177384
135Choline metabolism in cancer_Homo sapiens_hsa052310.47644780
136TNF signaling pathway_Homo sapiens_hsa046680.47055948
137Fructose and mannose metabolism_Homo sapiens_hsa000510.46756496
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43174738
139Carbon metabolism_Homo sapiens_hsa012000.42772093
140Insulin signaling pathway_Homo sapiens_hsa049100.42235213
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42209612
142Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42204449
143Glioma_Homo sapiens_hsa052140.42120075
144Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41400096
145Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36754183
146Type II diabetes mellitus_Homo sapiens_hsa049300.36720552
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33244488
148SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32976450

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