UBAP1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of light stimulus involved in visual perception (GO:0050908)8.60231633
2detection of light stimulus involved in sensory perception (GO:0050962)8.60231633
3phototransduction (GO:0007602)8.11101476
4GMP metabolic process (GO:0046037)7.91039517
5detection of light stimulus (GO:0009583)7.82977923
6phototransduction, visible light (GO:0007603)7.78680507
7detection of visible light (GO:0009584)7.62328503
8visual perception (GO:0007601)7.31995012
9sensory perception of light stimulus (GO:0050953)7.22992537
10positive regulation of guanylate cyclase activity (GO:0031284)6.27908685
11eye photoreceptor cell differentiation (GO:0001754)6.23045542
12photoreceptor cell differentiation (GO:0046530)6.23045542
13retina development in camera-type eye (GO:0060041)5.98901010
14cellular response to light stimulus (GO:0071482)5.89537090
15protein-chromophore linkage (GO:0018298)5.83649405
16regulation of guanylate cyclase activity (GO:0031282)5.61569059
17regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.60341212
18detection of external stimulus (GO:0009581)5.51246570
19detection of abiotic stimulus (GO:0009582)5.41158429
20membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.40707758
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.23654626
22regulation of short-term neuronal synaptic plasticity (GO:0048172)5.19717080
23regulation of clathrin-mediated endocytosis (GO:2000369)4.73691781
24negative regulation of synaptic transmission, GABAergic (GO:0032229)4.65391106
25nonmotile primary cilium assembly (GO:0035058)4.50294093
26synaptic vesicle maturation (GO:0016188)4.48518410
27protein localization to synapse (GO:0035418)4.39264110
28regulation of cGMP metabolic process (GO:0030823)4.33396290
29sodium ion export (GO:0071436)4.29738751
30cellular potassium ion homeostasis (GO:0030007)4.24171150
31dendritic spine morphogenesis (GO:0060997)4.20893466
32peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.05664117
33response to pheromone (GO:0019236)4.04673739
34neuronal action potential propagation (GO:0019227)3.95192957
35membrane depolarization during action potential (GO:0086010)3.94651652
36postsynaptic membrane organization (GO:0001941)3.88332877
37positive regulation of cGMP biosynthetic process (GO:0030828)3.87793432
38behavioral response to nicotine (GO:0035095)3.82796168
39cellular response to radiation (GO:0071478)3.82642856
40positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.75726991
41gamma-aminobutyric acid transport (GO:0015812)3.72147537
42positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.70464949
43retina layer formation (GO:0010842)3.70191119
44synaptic vesicle docking involved in exocytosis (GO:0016081)3.69279751
45post-embryonic morphogenesis (GO:0009886)3.63896513
46regulation of cGMP biosynthetic process (GO:0030826)3.60592286
47regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.60199222
48sensory perception (GO:0007600)3.56967664
49cell morphogenesis involved in neuron differentiation (GO:0048667)3.54602126
50regulation of synaptic vesicle exocytosis (GO:2000300)3.48943024
51ionotropic glutamate receptor signaling pathway (GO:0035235)3.46247765
52synaptic vesicle exocytosis (GO:0016079)3.42231194
53neuron development (GO:0048666)3.39679364
54positive regulation of cGMP metabolic process (GO:0030825)3.39462261
55neuromuscular synaptic transmission (GO:0007274)3.36478211
56regulation of voltage-gated calcium channel activity (GO:1901385)3.36045154
57membrane hyperpolarization (GO:0060081)3.33207119
58transmission of nerve impulse (GO:0019226)3.32370532
59urinary tract smooth muscle contraction (GO:0014848)3.31692241
60cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.30044111
61potassium ion homeostasis (GO:0055075)3.25072700
62proline transport (GO:0015824)3.24910026
63regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.24033221
64synaptic transmission, glutamatergic (GO:0035249)3.23681377
65response to light stimulus (GO:0009416)3.21277635
66estrogen biosynthetic process (GO:0006703)3.20389368
67regulation of glutamate receptor signaling pathway (GO:1900449)3.18423322
68activated T cell proliferation (GO:0050798)3.18093832
69axon ensheathment in central nervous system (GO:0032291)3.16871966
70central nervous system myelination (GO:0022010)3.16871966
71neurotransmitter-gated ion channel clustering (GO:0072578)3.14799863
72positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.13382582
73regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.11969955
74positive regulation of sodium ion transmembrane transport (GO:1902307)3.11793771
75regulation of synapse structural plasticity (GO:0051823)3.09617982
76membrane depolarization (GO:0051899)3.08909101
77cAMP catabolic process (GO:0006198)3.08165914
78negative regulation of receptor-mediated endocytosis (GO:0048261)3.05040005
79adaptation of signaling pathway (GO:0023058)3.04977519
80neurotransmitter transport (GO:0006836)3.03676765
81response to histamine (GO:0034776)3.01653894
82regulation of excitatory postsynaptic membrane potential (GO:0060079)3.00911779
83cyclic nucleotide catabolic process (GO:0009214)3.00687563
84regulation of synaptic vesicle transport (GO:1902803)3.00486503
85gamma-aminobutyric acid signaling pathway (GO:0007214)3.00459842
86behavioral response to ethanol (GO:0048149)3.00426544
87L-amino acid import (GO:0043092)3.00402063
88glutamate receptor signaling pathway (GO:0007215)2.99755857
89regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.97973760
90potassium ion import (GO:0010107)2.96706910
91presynaptic membrane assembly (GO:0097105)2.96370360
92chemosensory behavior (GO:0007635)2.94691746
93auditory behavior (GO:0031223)2.93891422
94positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.92594330
95establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.92051420
96mitochondrion transport along microtubule (GO:0047497)2.92051420
97glutamate secretion (GO:0014047)2.91192165
98pyrimidine nucleobase catabolic process (GO:0006208)2.90895612
99negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.90560317
100regulation of postsynaptic membrane potential (GO:0060078)2.90428763
101presynaptic membrane organization (GO:0097090)2.89663003
102neurotransmitter secretion (GO:0007269)2.88136011
103regulation of neurotransmitter levels (GO:0001505)2.87292525
104cerebellar Purkinje cell differentiation (GO:0021702)2.87129266
105positive regulation of synapse maturation (GO:0090129)2.84648028
106neuron-neuron synaptic transmission (GO:0007270)2.84558647
107neuromuscular process controlling posture (GO:0050884)2.84453198
108positive regulation of neurotransmitter transport (GO:0051590)2.84253902
109neuronal ion channel clustering (GO:0045161)2.83835151
110regulation of synapse maturation (GO:0090128)2.83038593
111synaptic vesicle endocytosis (GO:0048488)2.82854581
112cell communication by electrical coupling (GO:0010644)2.82231883
113regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.81971685
114regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.81971685
115righting reflex (GO:0060013)2.79786764
116startle response (GO:0001964)2.79502568
117neuron cell-cell adhesion (GO:0007158)2.78698894
118positive regulation of CREB transcription factor activity (GO:0032793)2.78261710
119receptor guanylyl cyclase signaling pathway (GO:0007168)2.77178405
120neuronal action potential (GO:0019228)2.74593215
121protein K11-linked deubiquitination (GO:0035871)2.71634073
122regulation of neurotransmitter secretion (GO:0046928)2.71497454
123cell differentiation in hindbrain (GO:0021533)2.71276870
124exploration behavior (GO:0035640)2.68452257
125positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.68201323
126axoneme assembly (GO:0035082)2.65516706
127positive regulation of membrane potential (GO:0045838)2.63789113
128mechanosensory behavior (GO:0007638)2.62221696
129adult walking behavior (GO:0007628)2.62112899
130synaptic transmission (GO:0007268)2.60568801
131regulation of neurotransmitter transport (GO:0051588)2.59775777
132L-fucose catabolic process (GO:0042355)2.58475637
133fucose catabolic process (GO:0019317)2.58475637
134L-fucose metabolic process (GO:0042354)2.58475637
135protein prenylation (GO:0018342)2.56443654
136prenylation (GO:0097354)2.56443654
137innervation (GO:0060384)2.55228890
138establishment of mitochondrion localization (GO:0051654)2.55122445
139locomotory exploration behavior (GO:0035641)2.54888977
140vocalization behavior (GO:0071625)2.53938250
141G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.52986774
142regulation of respiratory system process (GO:0044065)2.52908026
143striatum development (GO:0021756)2.50201542
144CDP-diacylglycerol biosynthetic process (GO:0016024)2.49704577
145cell migration in hindbrain (GO:0021535)2.49495695
146alanine transport (GO:0032328)2.49247401
147neurotransmitter catabolic process (GO:0042135)2.48220973
148synapse assembly (GO:0007416)2.46642010
149regulation of ARF protein signal transduction (GO:0032012)2.46400835
150nucleobase catabolic process (GO:0046113)2.46335312
151primary amino compound metabolic process (GO:1901160)2.46229747
152retina homeostasis (GO:0001895)2.45912762
153cellular sodium ion homeostasis (GO:0006883)2.44838853
154short-term memory (GO:0007614)2.44559239
155regulation of respiratory gaseous exchange (GO:0043576)2.44354918
156potassium ion transmembrane transport (GO:0071805)2.44299259
157cellular potassium ion transport (GO:0071804)2.44299259
158regulation of vesicle fusion (GO:0031338)2.43900034
159regulation of neuronal synaptic plasticity (GO:0048168)2.43767844
160positive regulation of vesicle fusion (GO:0031340)2.42664850
161negative regulation of cytosolic calcium ion concentration (GO:0051481)2.41931753
162serotonin metabolic process (GO:0042428)2.41709265
163neurotransmitter uptake (GO:0001504)2.41267041
164amino acid import (GO:0043090)2.39027501
165regulation of synaptic transmission, glutamatergic (GO:0051966)2.38423024
166establishment of protein localization to Golgi (GO:0072600)2.36064069
167regulation of calcium ion-dependent exocytosis (GO:0017158)2.35523932
168regulation of rhodopsin mediated signaling pathway (GO:0022400)13.3036307
169rhodopsin mediated signaling pathway (GO:0016056)12.9811248
170retinal cone cell development (GO:0046549)10.8585577
171photoreceptor cell maintenance (GO:0045494)10.6695310
172photoreceptor cell development (GO:0042461)10.4841212
173retinal rod cell development (GO:0046548)10.0531147
174eye photoreceptor cell development (GO:0042462)10.0003082

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.29005835
2CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.15219284
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.81028524
4DROSHA_22980978_ChIP-Seq_HELA_Human2.69556173
5SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.68567710
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.56446561
7GBX2_23144817_ChIP-Seq_PC3_Human2.55413137
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.52441117
9REST_21632747_ChIP-Seq_MESCs_Mouse2.37388410
10REST_18959480_ChIP-ChIP_MESCs_Mouse2.29429520
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.12190128
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.01725507
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.01725507
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.01725507
15ZNF274_21170338_ChIP-Seq_K562_Hela1.98162599
16EZH2_27294783_Chip-Seq_ESCs_Mouse1.97080000
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82430184
18EZH2_22144423_ChIP-Seq_EOC_Human1.82016611
19SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80661247
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79266493
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.77345193
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74573137
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74573137
24KDM2B_26808549_Chip-Seq_K562_Human1.73532297
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.71764162
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69832985
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.69455222
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67416557
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66044264
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64967110
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64689985
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63916072
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.63286139
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.58728831
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57741776
36RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.56500182
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56283250
38STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53668943
39P53_22127205_ChIP-Seq_FIBROBLAST_Human1.51555471
40SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.51392580
41AR_19668381_ChIP-Seq_PC3_Human1.50964575
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50304298
43RING1B_27294783_Chip-Seq_NPCs_Mouse1.50036047
44JARID2_20064375_ChIP-Seq_MESCs_Mouse1.48667039
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.47911303
46SMAD3_21741376_ChIP-Seq_HESCs_Human1.45531592
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43076793
48SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.41253869
49ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40394072
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37666791
51SMC4_20622854_ChIP-Seq_HELA_Human1.32713423
52TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31501895
53ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30722638
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27903505
55CTCF_27219007_Chip-Seq_Bcells_Human1.27518237
56IGF1R_20145208_ChIP-Seq_DFB_Human1.27418375
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26598366
58TCF4_23295773_ChIP-Seq_U87_Human1.26427624
59AR_21572438_ChIP-Seq_LNCaP_Human1.24646065
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23391684
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.20202914
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.19268680
63SMAD4_21799915_ChIP-Seq_A2780_Human1.19044056
64SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18865117
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17295701
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.16368098
67TBL1_22424771_ChIP-Seq_293T_Human1.16329021
68MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15484472
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15210446
70VDR_22108803_ChIP-Seq_LS180_Human1.15056914
71TAF15_26573619_Chip-Seq_HEK293_Human1.13534542
72RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13383349
73NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.13030855
74P68_20966046_ChIP-Seq_HELA_Human1.12937855
75ER_23166858_ChIP-Seq_MCF-7_Human1.12859622
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12384014
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12180725
78ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10904024
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09909588
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09502229
81EED_16625203_ChIP-ChIP_MESCs_Mouse1.09359715
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09000762
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09000762
84AR_25329375_ChIP-Seq_VCAP_Human1.08878401
85EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08792536
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.08588194
87TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08411913
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07918057
89BCAT_22108803_ChIP-Seq_LS180_Human1.07629559
90TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07394014
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06756730
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.05613372
93FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05498540
94ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05241173
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05110675
96STAT3_23295773_ChIP-Seq_U87_Human1.04308846
97SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.04128598
98SMAD4_21741376_ChIP-Seq_ESCs_Human1.03786335
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03440354
100TP63_19390658_ChIP-ChIP_HaCaT_Human1.02634124
101BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02515236
102CREB1_26743006_Chip-Seq_LNCaP_Human1.01627023
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.01329275
104ELK4_26923725_Chip-Seq_MESODERM_Mouse1.01219974
105P300_19829295_ChIP-Seq_ESCs_Human1.00733084
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00469652
107DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00468745
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99459650
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99181978
110RUNX_20019798_ChIP-Seq_JUKART_Human0.99008181
111NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.98374885
112NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.98252281
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97796732
114CBP_20019798_ChIP-Seq_JUKART_Human0.97796732
115WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96810140
116FLI1_21867929_ChIP-Seq_TH2_Mouse0.96668787
117OCT4_19829295_ChIP-Seq_ESCs_Human0.96418611
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96034968
119FLI1_27457419_Chip-Seq_LIVER_Mouse0.95773775
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95366087
121RUNX2_22187159_ChIP-Seq_PCA_Human0.95303691
122GATA1_26923725_Chip-Seq_HPCs_Mouse0.95170263
123ARNT_22903824_ChIP-Seq_MCF-7_Human0.95142031
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95100642
125TP53_16413492_ChIP-PET_HCT116_Human0.95011642
126POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94912296
127AHR_22903824_ChIP-Seq_MCF-7_Human0.93641171
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93546135
129POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93288470
130TCF4_18268006_ChIP-ChIP_LS174T_Human0.93068919
131SMAD4_21741376_ChIP-Seq_HESCs_Human0.92636271
132POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92286744
133DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92222118
134ISL1_27105846_Chip-Seq_CPCs_Mouse0.92180292
135NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92043766
136DPY_21335234_ChIP-Seq_ESCs_Mouse0.91277687
137OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90305947
138SMAD3_21741376_ChIP-Seq_ESCs_Human0.90007102
139PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88903645
140ERA_21632823_ChIP-Seq_H3396_Human0.88361678
141SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.88204076
142KDM2B_26808549_Chip-Seq_REH_Human0.88027685
143TCF3_18692474_ChIP-Seq_MESCs_Mouse0.87661987
144RNF2_27304074_Chip-Seq_NSC_Mouse0.86842557
145SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85244331
146TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84648552
147PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84345265
148MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82593979
149SMAD3_21741376_ChIP-Seq_EPCs_Human0.82196673
150MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82105706

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation8.62357146
2MP0005551_abnormal_eye_electrophysiolog8.44668825
3MP0006072_abnormal_retinal_apoptosis6.78069947
4MP0005253_abnormal_eye_physiology6.09700847
5MP0005195_abnormal_posterior_eye3.55200118
6MP0003950_abnormal_plasma_membrane3.43381937
7MP0005391_vision/eye_phenotype3.03062498
8MP0001324_abnormal_eye_pigmentation2.87091422
9MP0002653_abnormal_ependyma_morphology2.66804875
10MP0002229_neurodegeneration2.56467495
11MP0002638_abnormal_pupillary_reflex2.54967037
12MP0005423_abnormal_somatic_nervous2.47747020
13MP0002090_abnormal_vision2.39456708
14MP0004233_abnormal_muscle_weight2.06891236
15MP0002752_abnormal_somatic_nervous2.04920852
16MP0000569_abnormal_digit_pigmentation1.93621962
17MP0008877_abnormal_DNA_methylation1.86799659
18MP0002735_abnormal_chemical_nociception1.81237757
19MP0005394_taste/olfaction_phenotype1.74843938
20MP0005499_abnormal_olfactory_system1.74843938
21MP0001502_abnormal_circadian_rhythm1.71305934
22MP0004130_abnormal_muscle_cell1.71015472
23MP0006292_abnormal_olfactory_placode1.70448061
24MP0002733_abnormal_thermal_nociception1.68002158
25MP0003879_abnormal_hair_cell1.65890695
26MP0006276_abnormal_autonomic_nervous1.65406465
27MP0002882_abnormal_neuron_morphology1.61604614
28MP0004859_abnormal_synaptic_plasticity1.59742998
29MP0003880_abnormal_central_pattern1.58044485
30MP0002736_abnormal_nociception_after1.53303717
31MP0009046_muscle_twitch1.53025359
32MP0004885_abnormal_endolymph1.51619183
33MP0003646_muscle_fatigue1.50008872
34MP0008789_abnormal_olfactory_epithelium1.42598969
35MP0003195_calcinosis1.39106405
36MP0001486_abnormal_startle_reflex1.38691209
37MP0004043_abnormal_pH_regulation1.38518759
38MP0003635_abnormal_synaptic_transmissio1.36886232
39MP0003329_amyloid_beta_deposits1.32525392
40MP0001984_abnormal_olfaction1.31888745
41MP0002064_seizures1.29967021
42MP0004270_analgesia1.24399056
43MP0003690_abnormal_glial_cell1.23736853
44MP0000015_abnormal_ear_pigmentation1.19912722
45MP0001764_abnormal_homeostasis1.19285701
46MP0005171_absent_coat_pigmentation1.18512961
47MP0002272_abnormal_nervous_system1.18037028
48MP0010030_abnormal_orbit_morphology1.17875522
49MP0005167_abnormal_blood-brain_barrier1.16213733
50MP0005174_abnormal_tail_pigmentation1.11929201
51MP0004381_abnormal_hair_follicle1.11190714
52MP0001485_abnormal_pinna_reflex1.08808788
53MP0000372_irregular_coat_pigmentation1.06527031
54MP0000920_abnormal_myelination1.05355934
55MP0009745_abnormal_behavioral_response1.05129255
56MP0003890_abnormal_embryonic-extraembry1.02895565
57MP0002734_abnormal_mechanical_nocicepti1.02888092
58MP0004142_abnormal_muscle_tone1.00935432
59MP0002127_abnormal_cardiovascular_syste1.00698668
60MP0005645_abnormal_hypothalamus_physiol0.98435088
61MP0003123_paternal_imprinting0.97455584
62MP0002067_abnormal_sensory_capabilities0.95892076
63MP0002063_abnormal_learning/memory/cond0.95852509
64MP0003634_abnormal_glial_cell0.94514181
65MP0002876_abnormal_thyroid_physiology0.91257088
66MP0005535_abnormal_body_temperature0.88370460
67MP0003172_abnormal_lysosome_physiology0.85878943
68MP0002332_abnormal_exercise_endurance0.85391279
69MP0003136_yellow_coat_color0.85197192
70MP0002572_abnormal_emotion/affect_behav0.82862886
71MP0001188_hyperpigmentation0.82536601
72MP0002184_abnormal_innervation0.81220813
73MP0000631_abnormal_neuroendocrine_gland0.80772479
74MP0005248_abnormal_Harderian_gland0.80404726
75MP0001968_abnormal_touch/_nociception0.80365685
76MP0010386_abnormal_urinary_bladder0.78969599
77MP0002234_abnormal_pharynx_morphology0.78861465
78MP0001905_abnormal_dopamine_level0.78661305
79MP0005448_abnormal_energy_balance0.78116261
80MP0005075_abnormal_melanosome_morpholog0.77607430
81MP0004145_abnormal_muscle_electrophysio0.77239096
82MP0004019_abnormal_vitamin_homeostasis0.75110465
83MP0002095_abnormal_skin_pigmentation0.74485062
84MP0001986_abnormal_taste_sensitivity0.73788722
85MP0003283_abnormal_digestive_organ0.73556466
86MP0001286_abnormal_eye_development0.69786443
87MP0001963_abnormal_hearing_physiology0.69108575
88MP0000427_abnormal_hair_cycle0.67677468
89MP0005197_abnormal_uvea_morphology0.67664111
90MP0000955_abnormal_spinal_cord0.67146662
91MP0002697_abnormal_eye_size0.67001554
92MP0008995_early_reproductive_senescence0.66056758
93MP0005671_abnormal_response_to0.65582987
94MP0004147_increased_porphyrin_level0.65566852
95MP0002152_abnormal_brain_morphology0.65539284
96MP0008875_abnormal_xenobiotic_pharmacok0.65357833
97MP0005623_abnormal_meninges_morphology0.64652148
98MP0003045_fibrosis0.64258324
99MP0000778_abnormal_nervous_system0.64172589
100MP0003724_increased_susceptibility_to0.61657539
101MP0005386_behavior/neurological_phenoty0.61294656
102MP0004924_abnormal_behavior0.61294656
103MP0004811_abnormal_neuron_physiology0.61129148
104MP0000604_amyloidosis0.60810773
105MP0005187_abnormal_penis_morphology0.60024198
106MP0002066_abnormal_motor_capabilities/c0.59707134
107MP0003632_abnormal_nervous_system0.59328928
108MP0008569_lethality_at_weaning0.58526992
109MP0001501_abnormal_sleep_pattern0.56173930
110MP0002557_abnormal_social/conspecific_i0.55884770
111MP0005670_abnormal_white_adipose0.54182274
112MP0003122_maternal_imprinting0.53643099
113MP0003861_abnormal_nervous_system0.49545111
114MP0001970_abnormal_pain_threshold0.48706075
115MP0003787_abnormal_imprinting0.48070781
116MP0003633_abnormal_nervous_system0.47945458
117MP0001346_abnormal_lacrimal_gland0.47576846
118MP0000751_myopathy0.45567786
119MP0000026_abnormal_inner_ear0.43863975
120MP0001293_anophthalmia0.43379485
121MP0003631_nervous_system_phenotype0.43017068
122MP0005076_abnormal_cell_differentiation0.42713386
123MP0001440_abnormal_grooming_behavior0.42658461
124MP0004215_abnormal_myocardial_fiber0.42110023
125MP0003121_genomic_imprinting0.40129342
126MP0004133_heterotaxia0.38849672
127MP0002102_abnormal_ear_morphology0.37874645
128MP0005646_abnormal_pituitary_gland0.37046715
129MP0004742_abnormal_vestibular_system0.35768976
130MP0003137_abnormal_impulse_conducting0.34785909
131MP0008961_abnormal_basal_metabolism0.34634109
132MP0004782_abnormal_surfactant_physiolog0.33057436
133MP0009780_abnormal_chondrocyte_physiolo0.32543462
134MP0004085_abnormal_heartbeat0.31184191
135MP0008872_abnormal_physiological_respon0.30594319
136MP0002069_abnormal_eating/drinking_beha0.29690020
137MP0005376_homeostasis/metabolism_phenot0.29539505
138MP0002082_postnatal_lethality0.29463560
139MP0010770_preweaning_lethality0.29463560
140MP0010769_abnormal_survival0.29089416

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)9.91100933
2Abnormal rod and cone electroretinograms (HP:0008323)9.72640081
3Chorioretinal atrophy (HP:0000533)8.75485941
4Central scotoma (HP:0000603)8.15837445
5Pigmentary retinal degeneration (HP:0001146)7.99874654
6Pendular nystagmus (HP:0012043)7.89239361
7Scotoma (HP:0000575)7.11056025
8Abolished electroretinogram (ERG) (HP:0000550)6.95511374
9Attenuation of retinal blood vessels (HP:0007843)6.74295051
10Abnormality of macular pigmentation (HP:0008002)6.65899733
11Dyschromatopsia (HP:0007641)6.44259679
12Decreased central vision (HP:0007663)5.84025784
13Posterior subcapsular cataract (HP:0007787)5.77145634
14Type II diabetes mellitus (HP:0005978)5.36222688
15Severe visual impairment (HP:0001141)5.23100342
16Photophobia (HP:0000613)5.00321570
17Vitreoretinal degeneration (HP:0000655)4.75230861
18Increased corneal curvature (HP:0100692)4.68549976
19Keratoconus (HP:0000563)4.68549976
20Focal motor seizures (HP:0011153)4.68404562
21Macular degeneration (HP:0000608)4.66212923
22Cone-rod dystrophy (HP:0000548)4.55762861
23Hyperventilation (HP:0002883)4.16446300
24Constricted visual fields (HP:0001133)4.01753919
25Retinitis pigmentosa (HP:0000510)4.00266690
26Atonic seizures (HP:0010819)3.87889361
27Subcapsular cataract (HP:0000523)3.50183907
28Choroideremia (HP:0001139)3.36577542
29Clumsiness (HP:0002312)3.33133822
30Dialeptic seizures (HP:0011146)3.32129500
31Broad-based gait (HP:0002136)3.26711695
32Papilledema (HP:0001085)3.17923616
33Absence seizures (HP:0002121)3.15442129
34Absent speech (HP:0001344)3.11917567
35Progressive visual loss (HP:0000529)2.92699995
36Gaze-evoked nystagmus (HP:0000640)2.77481706
37Decreased electroretinogram (ERG) amplitude (HP:0000654)2.77152488
38Protruding tongue (HP:0010808)2.71312594
39Polyphagia (HP:0002591)2.70486713
40Congenital sensorineural hearing impairment (HP:0008527)2.68702368
41Abnormal eating behavior (HP:0100738)2.66414675
42Generalized tonic-clonic seizures (HP:0002069)2.65371381
43Nephronophthisis (HP:0000090)2.63873245
44Impaired smooth pursuit (HP:0007772)2.58508780
45Status epilepticus (HP:0002133)2.56053791
46Generalized hypopigmentation of hair (HP:0011358)2.53249968
47Gait imbalance (HP:0002141)2.52861375
48Polydipsia (HP:0001959)2.51434568
49Abnormal drinking behavior (HP:0030082)2.51434568
50Epileptiform EEG discharges (HP:0011182)2.48126336
51Congenital primary aphakia (HP:0007707)2.45296716
52Morphological abnormality of the pyramidal tract (HP:0002062)2.44814384
53Inability to walk (HP:0002540)2.44123195
54Wide nasal bridge (HP:0000431)2.43979440
55Prolonged QT interval (HP:0001657)2.42658678
56Limb dystonia (HP:0002451)2.40133638
57Spastic gait (HP:0002064)2.38787057
58Drooling (HP:0002307)2.37704496
59EEG with generalized epileptiform discharges (HP:0011198)2.36013174
60Excessive salivation (HP:0003781)2.33530276
61Blue irides (HP:0000635)2.32745490
62Hypsarrhythmia (HP:0002521)2.30718802
63Fair hair (HP:0002286)2.28950389
64Abnormality of the renal medulla (HP:0100957)2.24800648
65Agitation (HP:0000713)2.24730667
66Chronic hepatic failure (HP:0100626)2.18937753
67Abnormal EKG (HP:0003115)2.17551078
68Abnormality of the corticospinal tract (HP:0002492)2.17465167
69Polyuria (HP:0000103)2.14125303
70Nephrogenic diabetes insipidus (HP:0009806)2.11624792
71Sleep apnea (HP:0010535)2.08268182
72Abnormality of the renal cortex (HP:0011035)2.07684457
73Widely spaced teeth (HP:0000687)2.06489769
74Optic disc pallor (HP:0000543)2.04381145
75Stomach cancer (HP:0012126)2.03617564
76Decreased circulating renin level (HP:0003351)2.02736699
77Progressive inability to walk (HP:0002505)2.02121503
78Congenital stationary night blindness (HP:0007642)12.7462230
79Bony spicule pigmentary retinopathy (HP:0007737)10.5226274
80Visual hallucinations (HP:0002367)1.98733794
81Medial flaring of the eyebrow (HP:0010747)1.98390245
82Dysdiadochokinesis (HP:0002075)1.90688010
83Tented upper lip vermilion (HP:0010804)1.90410600
84Poor coordination (HP:0002370)1.87902059
85Iris hypopigmentation (HP:0007730)1.87474806
86Amblyopia (HP:0000646)1.87415261
87Polar cataract (HP:0010696)1.87079260
88Intellectual disability, severe (HP:0010864)1.86668977
89Clonus (HP:0002169)1.84114875
90Progressive cerebellar ataxia (HP:0002073)1.83142749
91Degeneration of the lateral corticospinal tracts (HP:0002314)1.80698475
92Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80698475
93Ulnar claw (HP:0001178)1.79588624
94Ocular albinism (HP:0001107)1.79583467
95Akinesia (HP:0002304)1.79386595
96Fetal akinesia sequence (HP:0001989)1.78551198
97Stereotypic behavior (HP:0000733)1.78312602
98Horizontal nystagmus (HP:0000666)1.77498920
99Retinal atrophy (HP:0001105)1.76753780
100Septo-optic dysplasia (HP:0100842)1.75730605
101Spastic tetraplegia (HP:0002510)1.74764221
102Progressive microcephaly (HP:0000253)1.73334353
103Amelogenesis imperfecta (HP:0000705)1.70642490
104Slow saccadic eye movements (HP:0000514)1.70101848
105Mutism (HP:0002300)1.69393542
106Annular pancreas (HP:0001734)1.69036918
107Abnormal urine output (HP:0012590)1.68583969
108Poor eye contact (HP:0000817)1.68534107
109Impaired vibration sensation in the lower limbs (HP:0002166)1.68198985
110Vaginal atresia (HP:0000148)1.68056086
111Epileptic encephalopathy (HP:0200134)1.67060880
112Genital tract atresia (HP:0001827)1.66094143
113Tubular atrophy (HP:0000092)1.66041106
114Pancreatic fibrosis (HP:0100732)1.60551270
115Febrile seizures (HP:0002373)1.58241868
116Optic atrophy (HP:0000648)1.56532663
117Abnormality of the lower motor neuron (HP:0002366)1.53813407
118True hermaphroditism (HP:0010459)1.51787309
119Abnormality of the parathyroid morphology (HP:0011766)1.47628304
120Sclerocornea (HP:0000647)1.46753916
121Specific learning disability (HP:0001328)1.43151293
122Aplasia/Hypoplasia of the lens (HP:0008063)1.41296080
123Severe Myopia (HP:0011003)1.37219100
124Cystic liver disease (HP:0006706)1.35053963
125Aplasia/Hypoplasia of the tongue (HP:0010295)1.31953419
126Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.30389278
127Supranuclear gaze palsy (HP:0000605)1.29670977
128Astigmatism (HP:0000483)1.26576296
129Genetic anticipation (HP:0003743)1.25559682
130Postural instability (HP:0002172)1.25108188
131Chorioretinal coloboma (HP:0000567)1.22721122
132Pancreatic cysts (HP:0001737)1.22476021
133Depression (HP:0000716)1.21797198
134Anophthalmia (HP:0000528)1.19936992
135Abdominal situs inversus (HP:0003363)1.19404812
136Abnormality of abdominal situs (HP:0011620)1.19404812
137Interstitial pulmonary disease (HP:0006530)1.18298404
138Truncal ataxia (HP:0002078)1.16978697
139Focal seizures (HP:0007359)1.13714989
140Ependymoma (HP:0002888)1.13627894
141Urinary bladder sphincter dysfunction (HP:0002839)1.12123049
142Abnormality of the fovea (HP:0000493)1.11520612
143Action tremor (HP:0002345)1.11485809
144Myokymia (HP:0002411)1.11122080
145Hypoplasia of the fovea (HP:0007750)1.08166173
146Aplasia/Hypoplasia of the fovea (HP:0008060)1.08166173
147Molar tooth sign on MRI (HP:0002419)1.08156501
148Abnormality of midbrain morphology (HP:0002418)1.08156501
149Abnormality of the astrocytes (HP:0100707)1.06123679
150Astrocytoma (HP:0009592)1.06123679
151Insomnia (HP:0100785)1.03562730
152Decreased testicular size (HP:0008734)1.03157954
153Broad foot (HP:0001769)1.02970937
154Abnormality of ocular smooth pursuit (HP:0000617)1.02009925
155Ankle clonus (HP:0011448)1.01799644
156Intention tremor (HP:0002080)0.99259747
157Neoplasm of the oral cavity (HP:0100649)0.98586319
158Hemiparesis (HP:0001269)0.97951238
159Left ventricular hypertrophy (HP:0001712)0.97883089
160Bradykinesia (HP:0002067)0.96766264
161Hemiplegia (HP:0002301)0.96532733
162Hand muscle atrophy (HP:0009130)0.95641862
163Abnormality of binocular vision (HP:0011514)0.93657955
164Diplopia (HP:0000651)0.93657955
165Asthma (HP:0002099)0.93630506

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK17.88362326
2IRAK23.65729862
3FRK3.38299717
4PBK3.35891614
5MAP3K92.89781544
6TAOK32.76739393
7PINK12.75299036
8NTRK32.65791056
9MAP3K42.55061725
10DAPK22.51746310
11CASK2.22527275
12PAK62.13029350
13NEK12.05812961
14STK382.00549446
15EPHA41.97158940
16CAMKK21.91082833
17AKT31.83800949
18CDK121.82087058
19PNCK1.78503234
20BMPR1B1.77358801
21MARK11.63215932
22ADRBK21.55946300
23BRD41.54821385
24WNK41.47038868
25INSRR1.44416920
26MAP4K11.40344080
27FGFR21.39522589
28ICK1.39247275
29SGK4941.39050084
30SGK2231.39050084
31TYRO31.38187495
32SIK21.37373244
33MAP3K101.35776670
34TXK1.29929353
35ALK1.29038394
36RIPK41.27024948
37NTRK21.26856551
38BLK1.21585246
39PRKD31.20608398
40DYRK1A1.19857715
41MINK11.18680676
42OXSR11.12685269
43GRK51.12569968
44GRK61.12549193
45CAMK1G1.12548422
46MAP2K71.08309003
47PLK21.03975494
48MAP2K41.03920047
49PRPF4B0.99571993
50CSNK1D0.97351902
51MAP2K60.96872942
52WNK10.96299935
53BMPR20.94264839
54HIPK20.92183424
55SYK0.88813637
56ADRBK10.87962490
57FES0.84246791
58ERBB20.83487930
59PTK2B0.83077310
60CAMK1D0.82879142
61PRKCH0.82873746
62TLK10.82865307
63TNK20.82799569
64MAPK100.82581832
65TTK0.81411301
66SGK20.80499393
67MAPK70.80240339
68NEK60.79844679
69TNIK0.79374777
70PHKG20.78366561
71PHKG10.78366561
72CDC42BPA0.78044746
73SGK30.77561274
74PKN10.77520779
75MAPK120.77466682
76MAP4K20.77233246
77PLK30.75179558
78TAOK20.74582865
79LATS20.74119642
80GSK3B0.73744207
81MUSK0.73606523
82PRKAA10.71841373
83CDK30.71795923
84DYRK20.71722727
85NUAK10.70885047
86ITK0.70706893
87CDK50.70665122
88RPS6KA30.68754452
89PDK10.66832912
90PRKCB0.66733887
91STK110.65256790
92MAPK90.65151873
93CAMK2D0.63992635
94SGK10.62973872
95CDK10.62840542
96PRKD20.62821453
97MAPK140.62669172
98MAP3K70.62602576
99PRKCZ0.62352299
100PRKCG0.62144019
101CSNK1E0.61538175
102CDC70.60649234
103PRKDC0.56896413
104MARK20.56050318
105CHEK10.53406496
106OBSCN0.53331063
107CAMK2A0.52590050
108ATM0.52585182
109CAMKK10.51804203
110CDK20.50555812
111CAMK10.49859913
112NEK20.49605192
113WNK30.49320492
114STK390.49203728
115PRKCQ0.48843956
116MAPK80.48789728
117UHMK10.48388095
118CDK150.48343193
119DYRK1B0.48328808
120PRKACG0.47697740
121MTOR0.47088981
122CAMK2B0.46515304
123CAMK40.45804890
124CDK90.44687733
125MAP2K20.43670226
126AKT20.43489731
127PRKACA0.43377283
128CDK180.43286395
129BTK0.43096648
130CDK190.42974287
131FER0.42666709
132MAPK150.42433090
133MAP3K110.42422720
134EPHA20.42325118
135PIK3CA0.41953199
136MAPK130.41852886
137ATR0.41787884
138PAK30.41474912
139PRKG10.40616474
140SCYL20.40484201
141MAP3K130.40290454
142MAPK10.39745417
143CDK140.39424177
144PDPK10.39154064
145LCK0.38715464
146JAK10.36768063
147EPHB10.36754525

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.71486396
2GABAergic synapse_Homo sapiens_hsa047272.26942598
3Nicotine addiction_Homo sapiens_hsa050332.10607150
4Phototransduction_Homo sapiens_hsa0474413.5625061
5Olfactory transduction_Homo sapiens_hsa047401.82609432
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78722464
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.69930984
8Morphine addiction_Homo sapiens_hsa050321.66745431
9Linoleic acid metabolism_Homo sapiens_hsa005911.56360206
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53256178
11Circadian entrainment_Homo sapiens_hsa047131.45943569
12Glutamatergic synapse_Homo sapiens_hsa047241.40748815
13Dorso-ventral axis formation_Homo sapiens_hsa043201.40144827
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37720386
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31997738
16Cholinergic synapse_Homo sapiens_hsa047251.30317960
17Dopaminergic synapse_Homo sapiens_hsa047281.23248033
18Circadian rhythm_Homo sapiens_hsa047101.18930038
19Butanoate metabolism_Homo sapiens_hsa006501.12185220
20Insulin secretion_Homo sapiens_hsa049111.06126340
21Ether lipid metabolism_Homo sapiens_hsa005651.05699428
22Serotonergic synapse_Homo sapiens_hsa047261.01111211
23Ovarian steroidogenesis_Homo sapiens_hsa049130.99499260
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89820535
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88490231
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86604409
27Oxytocin signaling pathway_Homo sapiens_hsa049210.84546048
28Cardiac muscle contraction_Homo sapiens_hsa042600.83308829
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81480671
30Salivary secretion_Homo sapiens_hsa049700.81271120
31Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81218200
32Regulation of autophagy_Homo sapiens_hsa041400.76705858
33Gastric acid secretion_Homo sapiens_hsa049710.73757911
34Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73676848
35Nitrogen metabolism_Homo sapiens_hsa009100.73352374
36Retinol metabolism_Homo sapiens_hsa008300.73236251
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73180140
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72923297
39Long-term potentiation_Homo sapiens_hsa047200.71195189
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71181765
41T cell receptor signaling pathway_Homo sapiens_hsa046600.70857452
42cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68701763
43Inositol phosphate metabolism_Homo sapiens_hsa005620.68662274
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66976659
45Amphetamine addiction_Homo sapiens_hsa050310.63620550
46Taste transduction_Homo sapiens_hsa047420.62959372
47Type II diabetes mellitus_Homo sapiens_hsa049300.62610061
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60134549
49mRNA surveillance pathway_Homo sapiens_hsa030150.59566186
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59376664
51Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59192285
52ABC transporters_Homo sapiens_hsa020100.59186582
53Fructose and mannose metabolism_Homo sapiens_hsa000510.59142848
54mTOR signaling pathway_Homo sapiens_hsa041500.58436230
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58163302
56cAMP signaling pathway_Homo sapiens_hsa040240.57494870
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56951079
58Calcium signaling pathway_Homo sapiens_hsa040200.56528381
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56507812
60Primary immunodeficiency_Homo sapiens_hsa053400.55952496
61Dilated cardiomyopathy_Homo sapiens_hsa054140.55829442
62Renin secretion_Homo sapiens_hsa049240.55719262
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53513119
64VEGF signaling pathway_Homo sapiens_hsa043700.53358567
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49343294
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.49268438
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48777040
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48375123
69Collecting duct acid secretion_Homo sapiens_hsa049660.48173399
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46210485
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46035140
72Biosynthesis of amino acids_Homo sapiens_hsa012300.45273313
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.44879283
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.44717225
75Prolactin signaling pathway_Homo sapiens_hsa049170.44418218
76Arachidonic acid metabolism_Homo sapiens_hsa005900.44036478
77Cocaine addiction_Homo sapiens_hsa050300.43935707
78Chemokine signaling pathway_Homo sapiens_hsa040620.43268220
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42174928
80GnRH signaling pathway_Homo sapiens_hsa049120.41382098
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41348067
82Rap1 signaling pathway_Homo sapiens_hsa040150.41143205
83Oocyte meiosis_Homo sapiens_hsa041140.41117239
84Alcoholism_Homo sapiens_hsa050340.40954797
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39374502
86Glucagon signaling pathway_Homo sapiens_hsa049220.38390425
87Galactose metabolism_Homo sapiens_hsa000520.37744968
88FoxO signaling pathway_Homo sapiens_hsa040680.36387739
89Bile secretion_Homo sapiens_hsa049760.36009854
90Histidine metabolism_Homo sapiens_hsa003400.35279773
91Mineral absorption_Homo sapiens_hsa049780.35256583
92Glycerolipid metabolism_Homo sapiens_hsa005610.34776270
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34610408
94Pancreatic secretion_Homo sapiens_hsa049720.34333472
95MAPK signaling pathway_Homo sapiens_hsa040100.34016506
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32834349
97Long-term depression_Homo sapiens_hsa047300.31184503
98Hippo signaling pathway_Homo sapiens_hsa043900.31183965
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30977255
100Platelet activation_Homo sapiens_hsa046110.30707966
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30341446
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28868708
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.28629067
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28278309
105Thyroid hormone synthesis_Homo sapiens_hsa049180.28040570
106Purine metabolism_Homo sapiens_hsa002300.27739281
107Tight junction_Homo sapiens_hsa045300.27665844
108Lysine degradation_Homo sapiens_hsa003100.26995734
109RNA degradation_Homo sapiens_hsa030180.26694679
110Vibrio cholerae infection_Homo sapiens_hsa051100.26488805
111Axon guidance_Homo sapiens_hsa043600.25676732
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25430090
113Wnt signaling pathway_Homo sapiens_hsa043100.25102314
114ErbB signaling pathway_Homo sapiens_hsa040120.24638919
115HIF-1 signaling pathway_Homo sapiens_hsa040660.23752499
116Notch signaling pathway_Homo sapiens_hsa043300.23497570
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.23365133
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.23264845
119AMPK signaling pathway_Homo sapiens_hsa041520.22426135
120Fatty acid biosynthesis_Homo sapiens_hsa000610.22143222
121Hedgehog signaling pathway_Homo sapiens_hsa043400.22013640
122Ras signaling pathway_Homo sapiens_hsa040140.21294180
123Gap junction_Homo sapiens_hsa045400.21272581
124Choline metabolism in cancer_Homo sapiens_hsa052310.21081211
125Estrogen signaling pathway_Homo sapiens_hsa049150.20714911
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19336621
127Melanogenesis_Homo sapiens_hsa049160.18705609
128Arginine biosynthesis_Homo sapiens_hsa002200.17350157
1292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.17239142
130Glioma_Homo sapiens_hsa052140.16376739
131Insulin signaling pathway_Homo sapiens_hsa049100.15783971

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