UBAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a UBA (ubiquitin associated) domain, which is characteristic of proteins that function in the ubiquitination pathway. This gene may show increased expression in the adrenal gland and lymphatic tissues. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of somitogenesis (GO:0014807)5.61642443
2regulation of DNA damage checkpoint (GO:2000001)4.92673052
3viral mRNA export from host cell nucleus (GO:0046784)4.88306416
4nuclear pore complex assembly (GO:0051292)4.66725789
5nuclear pore organization (GO:0006999)4.63787863
6DNA unwinding involved in DNA replication (GO:0006268)4.52350225
7centriole replication (GO:0007099)4.41212630
8protein localization to kinetochore (GO:0034501)4.34592511
9mitotic nuclear envelope disassembly (GO:0007077)4.31267648
10microtubule depolymerization (GO:0007019)4.28996244
11prenylation (GO:0097354)4.26230105
12protein prenylation (GO:0018342)4.26230105
13pre-miRNA processing (GO:0031054)4.17648363
14acrosome reaction (GO:0007340)4.12657731
15heterochromatin organization (GO:0070828)4.10899441
16fusion of sperm to egg plasma membrane (GO:0007342)4.05110020
17nuclear envelope disassembly (GO:0051081)4.04151613
18membrane disassembly (GO:0030397)4.04151613
19DNA packaging (GO:0006323)4.02781444
20sperm motility (GO:0030317)4.01149069
21mitotic sister chromatid segregation (GO:0000070)3.88018289
22protein localization to chromosome, centromeric region (GO:0071459)3.87719170
23establishment of protein localization to Golgi (GO:0072600)3.86820877
24regulation of centriole replication (GO:0046599)3.81603286
25retrograde transport, vesicle recycling within Golgi (GO:0000301)3.79717825
26single strand break repair (GO:0000012)3.77925628
27mitotic sister chromatid cohesion (GO:0007064)3.71290798
28protein targeting to Golgi (GO:0000042)3.70413325
29sister chromatid segregation (GO:0000819)3.70185560
30rRNA methylation (GO:0031167)3.64600905
31mitotic metaphase plate congression (GO:0007080)3.61566339
32formation of translation preinitiation complex (GO:0001731)3.58281705
33regulation of translational fidelity (GO:0006450)3.54853071
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.52963501
35mitotic chromosome condensation (GO:0007076)3.47676911
36regulation of spindle organization (GO:0090224)3.44842966
37positive regulation of chromosome segregation (GO:0051984)3.42420216
38pore complex assembly (GO:0046931)3.42276032
39regulation of gene silencing by RNA (GO:0060966)3.42035233
40regulation of posttranscriptional gene silencing (GO:0060147)3.42035233
41regulation of gene silencing by miRNA (GO:0060964)3.42035233
42paraxial mesoderm development (GO:0048339)3.41813412
43DNA replication initiation (GO:0006270)3.41297067
44DNA replication-dependent nucleosome assembly (GO:0006335)3.41092013
45DNA replication-dependent nucleosome organization (GO:0034723)3.41092013
46centriole assembly (GO:0098534)3.38495678
47folic acid-containing compound biosynthetic process (GO:0009396)3.37652957
48DNA strand elongation involved in DNA replication (GO:0006271)3.34747835
49positive regulation of RNA splicing (GO:0033120)3.31056767
50DNA duplex unwinding (GO:0032508)3.30073983
51IMP biosynthetic process (GO:0006188)3.29501956
52DNA geometric change (GO:0032392)3.29441934
53negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.27121997
54negative regulation of histone methylation (GO:0031061)3.26754159
55dosage compensation (GO:0007549)3.26101027
56nuclear envelope organization (GO:0006998)3.25505783
57replicative senescence (GO:0090399)3.23100187
58regulation of RNA export from nucleus (GO:0046831)3.23024186
59microtubule polymerization or depolymerization (GO:0031109)3.21771670
60metaphase plate congression (GO:0051310)3.20195628
61regulation of mitotic spindle organization (GO:0060236)3.19219744
62DNA strand elongation (GO:0022616)3.17571134
63spermatid development (GO:0007286)3.14795278
64positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.13922257
65positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.13922257
66positive regulation of mitotic sister chromatid separation (GO:1901970)3.13922257
67regulation of sister chromatid cohesion (GO:0007063)3.13384864
68DNA replication checkpoint (GO:0000076)3.12860174
69protein polyglutamylation (GO:0018095)3.12850348
70sperm-egg recognition (GO:0035036)3.06905291
71histone-serine phosphorylation (GO:0035404)3.06655717
72regulation of translational termination (GO:0006449)3.05904472
73protein localization to chromosome (GO:0034502)3.05016273
74male meiosis I (GO:0007141)3.04335143
75regulation of histone H3-K9 methylation (GO:0051570)3.03517662
76negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.99294924
77RNA stabilization (GO:0043489)2.99082437
78mRNA stabilization (GO:0048255)2.99082437
79regulation of chromosome segregation (GO:0051983)2.98723992
80multicellular organism reproduction (GO:0032504)2.96851260
81intracellular estrogen receptor signaling pathway (GO:0030520)2.96152551
82nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.96061954
83plasma membrane fusion (GO:0045026)2.95459045
84gene silencing by RNA (GO:0031047)2.94731890
85histone exchange (GO:0043486)2.94706334
86rRNA modification (GO:0000154)2.94595687
87nucleobase biosynthetic process (GO:0046112)2.94147959
88negative regulation of RNA splicing (GO:0033119)2.94145981
89sulfation (GO:0051923)2.93334017
90peptidyl-arginine omega-N-methylation (GO:0035247)2.92860008
91kinetochore organization (GO:0051383)2.92781534
92regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.92045212
93negative regulation of chromosome segregation (GO:0051985)2.91127320
94IMP metabolic process (GO:0046040)2.91034048
95binding of sperm to zona pellucida (GO:0007339)2.89957361
96regulation of meiosis I (GO:0060631)2.89624046
97positive regulation of DNA-templated transcription, elongation (GO:0032786)2.89016424
98positive regulation of SMAD protein import into nucleus (GO:0060391)2.86311094
99attachment of spindle microtubules to kinetochore (GO:0008608)2.85411778
100negative regulation of mRNA processing (GO:0050686)2.84743155
101response to pheromone (GO:0019236)2.84367407
102negative regulation of DNA repair (GO:0045738)2.83324872
103bundle of His cell to Purkinje myocyte communication (GO:0086069)2.82757510
104lymphangiogenesis (GO:0001946)2.82362079
105maturation of SSU-rRNA (GO:0030490)2.81506651
106DNA conformation change (GO:0071103)2.81400082
107histone H3-K9 demethylation (GO:0033169)2.81354683
108chromatin silencing (GO:0006342)2.81061435
109negative regulation of mRNA metabolic process (GO:1903312)2.80690231
110coronary vasculature morphogenesis (GO:0060977)2.80392083
111NLS-bearing protein import into nucleus (GO:0006607)2.79078406
112negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.78994050
113negative regulation of sister chromatid segregation (GO:0033046)2.78994050
114negative regulation of mitotic sister chromatid separation (GO:2000816)2.78994050
115negative regulation of mitotic sister chromatid segregation (GO:0033048)2.78994050
116ribosome assembly (GO:0042255)2.78270749
117spindle assembly checkpoint (GO:0071173)2.78219324
118mitotic spindle assembly checkpoint (GO:0007094)2.78034964
119regulation of stem cell maintenance (GO:2000036)2.77528104
120establishment of chromosome localization (GO:0051303)2.77261382
121chromosome condensation (GO:0030261)2.77131641
122regulation of mitotic metaphase/anaphase transition (GO:0030071)2.75898745
123protein K48-linked deubiquitination (GO:0071108)2.75608833
124leukotriene biosynthetic process (GO:0019370)2.75277584
125chromatin assembly (GO:0031497)2.74917992
126gene silencing (GO:0016458)2.74785474
127positive regulation of mRNA processing (GO:0050685)2.73596545
128histone H4-K12 acetylation (GO:0043983)2.73479856
129trophectodermal cell differentiation (GO:0001829)2.71722732
130interkinetic nuclear migration (GO:0022027)2.71369949
131regulation of DNA endoreduplication (GO:0032875)2.71188772
132mitotic spindle checkpoint (GO:0071174)2.70967350
133spliceosomal tri-snRNP complex assembly (GO:0000244)2.70836105
134mRNA transport (GO:0051028)2.70678163
135telomere maintenance via semi-conservative replication (GO:0032201)2.70661272
136regulation of nucleobase-containing compound transport (GO:0032239)2.70656938
137spindle checkpoint (GO:0031577)2.70373385
138oogenesis (GO:0048477)2.70249052
139histone mRNA catabolic process (GO:0071044)2.69332909
140negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.69223524
141regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.68419141
142regulation of centrosome cycle (GO:0046605)2.67836829
143histone H2A monoubiquitination (GO:0035518)2.67753286
144chromatin assembly or disassembly (GO:0006333)2.66087365
145male gamete generation (GO:0048232)2.66054989
146spermatogenesis (GO:0007283)2.65585013
147regulation of mitotic sister chromatid separation (GO:0010965)2.64271327
148regulation of mitotic sister chromatid segregation (GO:0033047)2.64271327
149regulation of sister chromatid segregation (GO:0033045)2.64271327
150RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.64094783
151mRNA splicing, via spliceosome (GO:0000398)2.64094783
152RNA splicing, via transesterification reactions (GO:0000375)2.64016661
153regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.63390995
154histone H3-K36 demethylation (GO:0070544)2.62736855
155protein-DNA complex disassembly (GO:0032986)2.61178518
156gamete generation (GO:0007276)2.59826485
157DNA methylation involved in gamete generation (GO:0043046)2.58217215
158post-anal tail morphogenesis (GO:0036342)2.57585643
159sister chromatid cohesion (GO:0007062)2.56520174
160regulation of centrosome duplication (GO:0010824)2.55737744
161regulation of histone H3-K27 methylation (GO:0061085)2.54374683
162microtubule nucleation (GO:0007020)2.52225548
163histone lysine demethylation (GO:0070076)2.50985440
164microtubule anchoring (GO:0034453)2.50575596
165monoubiquitinated protein deubiquitination (GO:0035520)2.49474564
166positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.49196911
167germ cell development (GO:0007281)2.49066052
168regulation of cell cycle checkpoint (GO:1901976)2.47384234
169membrane protein ectodomain proteolysis (GO:0006509)2.46146037
170anterior/posterior axis specification, embryo (GO:0008595)2.45983074
171cell-cell recognition (GO:0009988)2.44929657
172spliceosomal complex assembly (GO:0000245)2.42887769
173histone demethylation (GO:0016577)2.41789705
174musculoskeletal movement (GO:0050881)2.40271904
175multicellular organismal movement (GO:0050879)2.40271904

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.20417695
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.01255636
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.14953351
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.66420271
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.55349840
6* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27597264
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.19868993
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.18905871
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.95315304
10* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82954058
11MYC_22102868_ChIP-Seq_BL_Human2.69086829
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.67646985
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.59776879
14EZH2_22144423_ChIP-Seq_EOC_Human2.49749952
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.35629980
16AR_21909140_ChIP-Seq_LNCAP_Human2.28117726
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13192645
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.12885399
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11223868
20XRN2_22483619_ChIP-Seq_HELA_Human2.07136741
21AR_21572438_ChIP-Seq_LNCaP_Human2.02095439
22* E2F1_21310950_ChIP-Seq_MCF-7_Human1.97222855
23FUS_26573619_Chip-Seq_HEK293_Human1.94653390
24* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94361547
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.94184429
26IRF1_19129219_ChIP-ChIP_H3396_Human1.92686078
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91223104
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80644668
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.78396278
30CIITA_25753668_ChIP-Seq_RAJI_Human1.77455722
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76619813
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.74569162
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.70703232
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69394731
35* ETS1_20019798_ChIP-Seq_JURKAT_Human1.68886475
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65303591
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64305041
38* EST1_17652178_ChIP-ChIP_JURKAT_Human1.63665291
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63536659
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61939219
41CBP_20019798_ChIP-Seq_JUKART_Human1.61939219
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61157263
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59946984
44VDR_21846776_ChIP-Seq_THP-1_Human1.56910084
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55752633
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55752633
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55459782
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53521993
49* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53093172
50PKCTHETA_26484144_Chip-Seq_BREAST_Human1.52661047
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51503289
52TTF2_22483619_ChIP-Seq_HELA_Human1.49552187
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.49266895
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48764588
55KDM5A_27292631_Chip-Seq_BREAST_Human1.46914625
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46622671
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45614932
58ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.45563967
59* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.44118085
60GATA1_26923725_Chip-Seq_HPCs_Mouse1.43699284
61* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41976345
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.41729617
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.41729617
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.41729617
65* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41428181
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36231684
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35751260
68GABP_19822575_ChIP-Seq_HepG2_Human1.35479097
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34670004
70GBX2_23144817_ChIP-Seq_PC3_Human1.32861913
71* NANOG_21062744_ChIP-ChIP_HESCs_Human1.32510578
72* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31613801
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31544507
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31079154
75HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30384147
76E2F1_17053090_ChIP-ChIP_MCF-7_Human1.30060856
77DCP1A_22483619_ChIP-Seq_HELA_Human1.28950335
78LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28799124
79THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28729076
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.26379622
81FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.26061643
82* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25709675
83TDRD3_21172665_ChIP-Seq_MCF-7_Human1.25185969
84FOXP3_21729870_ChIP-Seq_TREG_Human1.24718613
85TCF3_18692474_ChIP-Seq_MEFs_Mouse1.23407346
86TCF7_22412390_ChIP-Seq_EML_Mouse1.22114836
87JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21280720
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21194477
89ZNF263_19887448_ChIP-Seq_K562_Human1.20886307
90HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20500028
91VDR_23849224_ChIP-Seq_CD4+_Human1.19208962
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18937017
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.18057188
94STAT3_23295773_ChIP-Seq_U87_Human1.17422438
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.17311896
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17188220
97VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14265421
98KDM2B_26808549_Chip-Seq_DND41_Human1.14216425
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14053317
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.13784216
101SALL1_21062744_ChIP-ChIP_HESCs_Human1.13691250
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13487772
103TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12869774
104ATF3_27146783_Chip-Seq_COLON_Human1.12409684
105* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12249341
106SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11927209
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11784070
108NOTCH1_21737748_ChIP-Seq_TLL_Human1.11781122
109TP53_16413492_ChIP-PET_HCT116_Human1.11515010
110ZNF274_21170338_ChIP-Seq_K562_Hela1.11054416
111GF1B_26923725_Chip-Seq_HPCs_Mouse1.10180926
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08471753
113POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08435406
114* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08394960
115SMAD3_21741376_ChIP-Seq_EPCs_Human1.07958656
116CHD1_26751641_Chip-Seq_LNCaP_Human1.07611759
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07547702
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05901697
119VDR_22108803_ChIP-Seq_LS180_Human1.04952866
120ER_23166858_ChIP-Seq_MCF-7_Human1.04109193
121KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03927111
122POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03819810
123KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03441031
124KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03155859
125NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.02896536
126* TFEB_21752829_ChIP-Seq_HELA_Human1.02657379
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01960042
128ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01827026
129RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01802049
130ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01793972
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01602699
132GABP_17652178_ChIP-ChIP_JURKAT_Human1.01141673
133* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01056645
134EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00948824
135BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00642029
136TAF15_26573619_Chip-Seq_HEK293_Human0.99189057
137CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98960761
138SMAD4_21799915_ChIP-Seq_A2780_Human0.98589187
139SMAD3_21741376_ChIP-Seq_ESCs_Human0.98363683
140GF1_26923725_Chip-Seq_HPCs_Mouse0.96079193
141* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.95350904
142SOX2_16153702_ChIP-ChIP_HESCs_Human0.95048337
143TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95012820
144* SMAD4_21741376_ChIP-Seq_EPCs_Human0.94895993
145* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93940346
146P300_19829295_ChIP-Seq_ESCs_Human0.93859970
147SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93589444
148CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93241225
149PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92948332
150HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92458262
151UTX_26944678_Chip-Seq_JUKART_Human0.92364568
152NCOR1_26117541_ChIP-Seq_K562_Human0.92081391
153HOXB7_26014856_ChIP-Seq_BT474_Human0.91783896
154ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90406660
155POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90103163
156ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90057483
157NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88569005
158P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88447454
159TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88146223
160RNF2_27304074_Chip-Seq_NSC_Mouse0.87085875
161TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87068081
162POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85284863
163* TCF4_23295773_ChIP-Seq_U87_Human0.81899454
164AHR_22903824_ChIP-Seq_MCF-7_Human0.81749554
165RXR_22108803_ChIP-Seq_LS180_Human0.81635373
166RUNX1_26923725_Chip-Seq_HPCs_Mouse0.81553598
167EED_16625203_ChIP-ChIP_MESCs_Mouse0.81452021
168FOXM1_26456572_ChIP-Seq_MCF-7_Human0.80459197
169TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80255761
170EGR1_23403033_ChIP-Seq_LIVER_Mouse0.79754732
171EWS_26573619_Chip-Seq_HEK293_Human0.79503479
172NFYB_21822215_ChIP-Seq_K562_Human0.77451868
173ETV1_20927104_ChIP-Seq_GIST48_Human0.76689119
174* OCT1_27270436_Chip-Seq_PROSTATE_Human0.75972006
175PADI4_21655091_ChIP-ChIP_MCF-7_Human0.75647189
176WDR5_24793694_ChIP-Seq_LNCAP_Human0.75539684
177SOX9_26525672_Chip-Seq_HEART_Mouse0.73620454
178PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.72198335

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology3.91578723
2MP0003693_abnormal_embryo_hatching3.48072038
3MP0003111_abnormal_nucleus_morphology3.36464594
4MP0005410_abnormal_fertilization3.30459034
5MP0010094_abnormal_chromosome_stability3.28538088
6MP0004957_abnormal_blastocyst_morpholog3.19548912
7MP0003077_abnormal_cell_cycle3.00253512
8MP0010352_gastrointestinal_tract_polyps2.83072365
9MP0003183_abnormal_peptide_metabolism2.82425390
10MP0005379_endocrine/exocrine_gland_phen2.73301041
11MP0008057_abnormal_DNA_replication2.71863630
12MP0001730_embryonic_growth_arrest2.42020101
13MP0003705_abnormal_hypodermis_morpholog2.30638131
14MP0005076_abnormal_cell_differentiation2.30016885
15MP0003123_paternal_imprinting2.28045876
16MP0002160_abnormal_reproductive_system2.21179590
17MP0010030_abnormal_orbit_morphology2.13743940
18MP0000350_abnormal_cell_proliferation2.12431978
19MP0008877_abnormal_DNA_methylation2.09504136
20MP0000569_abnormal_digit_pigmentation2.05240018
21MP0005380_embryogenesis_phenotype2.05185343
22MP0001672_abnormal_embryogenesis/_devel2.05185343
23MP0003984_embryonic_growth_retardation1.96923280
24MP0002084_abnormal_developmental_patter1.94469877
25MP0002088_abnormal_embryonic_growth/wei1.93622840
26MP0001697_abnormal_embryo_size1.91766916
27MP0008932_abnormal_embryonic_tissue1.90630134
28MP0008007_abnormal_cellular_replicative1.90263709
29MP0004197_abnormal_fetal_growth/weight/1.87956244
30MP0002085_abnormal_embryonic_tissue1.87906090
31MP0003698_abnormal_male_reproductive1.87071730
32MP0000537_abnormal_urethra_morphology1.81489033
33MP0008058_abnormal_DNA_repair1.80581913
34MP0002396_abnormal_hematopoietic_system1.71086439
35MP0010368_abnormal_lymphatic_system1.69979542
36MP0003121_genomic_imprinting1.69398788
37MP0004233_abnormal_muscle_weight1.67867334
38MP0002086_abnormal_extraembryonic_tissu1.66799112
39MP0003878_abnormal_ear_physiology1.62570007
40MP0005377_hearing/vestibular/ear_phenot1.62570007
41MP0003567_abnormal_fetal_cardiomyocyte1.62319432
42MP0002653_abnormal_ependyma_morphology1.61952612
43MP0002080_prenatal_lethality1.60324279
44MP0002138_abnormal_hepatobiliary_system1.59597608
45MP0010307_abnormal_tumor_latency1.59099897
46MP0009053_abnormal_anal_canal1.55033352
47MP0001849_ear_inflammation1.52411030
48MP0000733_abnormal_muscle_development1.50767197
49MP0003566_abnormal_cell_adhesion1.49830688
50MP0009278_abnormal_bone_marrow1.47330930
51MP0003718_maternal_effect1.46586908
52MP0003890_abnormal_embryonic-extraembry1.44952984
53MP0003119_abnormal_digestive_system1.44824073
54MP0004145_abnormal_muscle_electrophysio1.42023327
55MP0004808_abnormal_hematopoietic_stem1.40773259
56MP0009697_abnormal_copulation1.40316080
57MP0000750_abnormal_muscle_regeneration1.40239168
58MP0001879_abnormal_lymphatic_vessel1.38050255
59MP0000049_abnormal_middle_ear1.37579632
60MP0002089_abnormal_postnatal_growth/wei1.36882297
61MP0000678_abnormal_parathyroid_gland1.31586464
62MP0005409_darkened_coat_color1.30598664
63MP0001348_abnormal_lacrimal_gland1.30279991
64MP0001293_anophthalmia1.22506520
65MP0000428_abnormal_craniofacial_morphol1.21808903
66MP0005623_abnormal_meninges_morphology1.20958460
67MP0002108_abnormal_muscle_morphology1.20582959
68MP0004084_abnormal_cardiac_muscle1.20371123
69MP0005083_abnormal_biliary_tract1.16984082
70MP0002127_abnormal_cardiovascular_syste1.14779203
71MP0002161_abnormal_fertility/fecundity1.14314512
72MP0000313_abnormal_cell_death1.13501744
73MP0009672_abnormal_birth_weight1.13449404
74MP0005023_abnormal_wound_healing1.12502925
75MP0002925_abnormal_cardiovascular_devel1.10991772
76MP0010630_abnormal_cardiac_muscle1.09535877
77MP0003786_premature_aging1.09352798
78MP0003115_abnormal_respiratory_system1.08934804
79MP0003937_abnormal_limbs/digits/tail_de1.07872833
80MP0005670_abnormal_white_adipose1.07807185
81MP0006292_abnormal_olfactory_placode1.06862633
82MP0000749_muscle_degeneration1.06612406
83MP0000490_abnormal_crypts_of1.06174970
84MP0000613_abnormal_salivary_gland1.05721268
85MP0003935_abnormal_craniofacial_develop1.03688757
86MP0009703_decreased_birth_body1.02844437
87MP0004133_heterotaxia1.02805231
88MP0005423_abnormal_somatic_nervous1.02659984
89MP0001915_intracranial_hemorrhage1.01527729
90MP0002210_abnormal_sex_determination0.99940461
91MP0004264_abnormal_extraembryonic_tissu0.98790000
92MP0002019_abnormal_tumor_incidence0.96937929
93MP0001545_abnormal_hematopoietic_system0.96804577
94MP0005397_hematopoietic_system_phenotyp0.96804577
95MP0004272_abnormal_basement_membrane0.96336430
96MP0005369_muscle_phenotype0.96308463
97MP0000432_abnormal_head_morphology0.95342699
98MP0000266_abnormal_heart_morphology0.95257523
99MP0005389_reproductive_system_phenotype0.95253175
100MP0002254_reproductive_system_inflammat0.93851603
101MP0004087_abnormal_muscle_fiber0.92888503
102MP0002697_abnormal_eye_size0.92427337
103MP0002111_abnormal_tail_morphology0.92006130
104MP0001485_abnormal_pinna_reflex0.91548558
105MP0001145_abnormal_male_reproductive0.90340768
106MP0003221_abnormal_cardiomyocyte_apopto0.88982994
107MP0003959_abnormal_lean_body0.88532766
108MP0003385_abnormal_body_wall0.87219184
109MP0005220_abnormal_exocrine_pancreas0.86897765
110MP0006276_abnormal_autonomic_nervous0.86866859
111MP0003283_abnormal_digestive_organ0.85527762
112MP0002269_muscular_atrophy0.85212342
113MP0003942_abnormal_urinary_system0.84702270
114MP0002932_abnormal_joint_morphology0.84664198
115MP0000759_abnormal_skeletal_muscle0.84659103
116MP0001929_abnormal_gametogenesis0.83446303
117MP0003656_abnormal_erythrocyte_physiolo0.81228975
118MP0003122_maternal_imprinting0.81010100
119MP0002092_abnormal_eye_morphology0.80838218
120MP0003755_abnormal_palate_morphology0.80523727
121MP0000751_myopathy0.80477234
122MP0003861_abnormal_nervous_system0.79870615
123MP0003941_abnormal_skin_development0.79701045
124MP0000703_abnormal_thymus_morphology0.78678067
125MP0000534_abnormal_ureter_morphology0.77626942
126MP0003646_muscle_fatigue0.76957418
127MP0004036_abnormal_muscle_relaxation0.76952603
128MP0003315_abnormal_perineum_morphology0.76814197
129MP0009780_abnormal_chondrocyte_physiolo0.76511011
130MP0003699_abnormal_female_reproductive0.75893639
131MP0008770_decreased_survivor_rate0.75819910
132MP0001286_abnormal_eye_development0.75625356
133MP0002234_abnormal_pharynx_morphology0.74844199
134MP0000003_abnormal_adipose_tissue0.74819562
135MP0005621_abnormal_cell_physiology0.74806991
136MP0005384_cellular_phenotype0.73965947
137MP0002081_perinatal_lethality0.73749373
138MP0006138_congestive_heart_failure0.73642996
139MP0002106_abnormal_muscle_physiology0.72793308
140MP0000653_abnormal_sex_gland0.72295910
141MP0001661_extended_life_span0.72127921
142MP0001119_abnormal_female_reproductive0.70370151
143MP0008995_early_reproductive_senescence0.70316291
144MP0008789_abnormal_olfactory_epithelium0.69868478
145MP0002116_abnormal_craniofacial_bone0.69837358
146MP0002114_abnormal_axial_skeleton0.69728619
147MP0004185_abnormal_adipocyte_glucose0.69364983
148MP0002877_abnormal_melanocyte_morpholog0.69237350
149MP0001784_abnormal_fluid_regulation0.68693771
150MP0000631_abnormal_neuroendocrine_gland0.67743323

Predicted human phenotypes

RankGene SetZ-score
1Diastasis recti (HP:0001540)5.35747876
2Vertebral arch anomaly (HP:0008438)4.73432697
3Anomalous pulmonary venous return (HP:0010772)4.12290995
4Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.96643006
5Ependymoma (HP:0002888)3.75623409
6Slow saccadic eye movements (HP:0000514)3.65881151
7Hyperkalemia (HP:0002153)3.57693407
8Abnormality of the pulmonary veins (HP:0011718)3.41827598
9Broad alveolar ridges (HP:0000187)3.38015938
10Tongue fasciculations (HP:0001308)3.37612216
11Selective tooth agenesis (HP:0001592)3.29194956
12Genetic anticipation (HP:0003743)3.21294545
13Thoracolumbar scoliosis (HP:0002944)3.16562471
14Short 4th metacarpal (HP:0010044)3.06618598
15Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.06618598
16Medulloblastoma (HP:0002885)2.97711168
17Flat acetabular roof (HP:0003180)2.95107239
18Muscle fibrillation (HP:0010546)2.93041841
19Astrocytoma (HP:0009592)2.89466264
20Abnormality of the astrocytes (HP:0100707)2.89466264
21Increased nuchal translucency (HP:0010880)2.79321738
22Abnormality of the odontoid process (HP:0003310)2.78397082
23Myelomeningocele (HP:0002475)2.78025102
24Deviation of the thumb (HP:0009603)2.76019515
25Colon cancer (HP:0003003)2.75009696
26Broad ribs (HP:0000885)2.74293168
27J-shaped sella turcica (HP:0002680)2.73640777
28Severe visual impairment (HP:0001141)2.71130622
29Proximal placement of thumb (HP:0009623)2.71049740
30Abnormal pancreas size (HP:0012094)2.58982297
31Hyperacusis (HP:0010780)2.50265570
32Patellar aplasia (HP:0006443)2.49135120
33Renal duplication (HP:0000075)2.48759627
34Long eyelashes (HP:0000527)2.46718449
35Glioma (HP:0009733)2.41759627
36Neoplasm of the oral cavity (HP:0100649)2.40364500
37Deformed sella turcica (HP:0002681)2.39871384
38Protrusio acetabuli (HP:0003179)2.39323842
39Abnormality of the nasal septum (HP:0000419)2.39043106
40Abnormal number of incisors (HP:0011064)2.37422829
41Abnormality of the intervertebral disk (HP:0005108)2.37065466
42Shallow orbits (HP:0000586)2.34212202
43Aplasia/Hypoplasia of the patella (HP:0006498)2.34000338
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.31957274
45Lip pit (HP:0100267)2.28735240
46Neoplasm of striated muscle (HP:0009728)2.28369699
47Abnormality of the fingertips (HP:0001211)2.27420287
48Abnormality of the 4th metacarpal (HP:0010012)2.27367861
49Abnormality of the sella turcica (HP:0002679)2.26894766
50Ankle contracture (HP:0006466)2.25183987
51Abnormality of the preputium (HP:0100587)2.24689557
52Aplasia/hypoplasia of the humerus (HP:0006507)2.22062208
53Abnormality of the labia minora (HP:0012880)2.20968174
54Trismus (HP:0000211)2.19498891
55Aortic regurgitation (HP:0001659)2.19143997
56Urethral obstruction (HP:0000796)2.19130438
57Abnormality of the lumbar spine (HP:0100712)2.19079924
58Ectopic kidney (HP:0000086)2.18341504
59Impaired smooth pursuit (HP:0007772)2.18184155
60Short humerus (HP:0005792)2.15907887
61Volvulus (HP:0002580)2.14850056
62Wide intermamillary distance (HP:0006610)2.12799533
63Rhabdomyosarcoma (HP:0002859)2.12525277
64Impulsivity (HP:0100710)2.12064652
65Abnormality of DNA repair (HP:0003254)2.11835524
66Atresia of the external auditory canal (HP:0000413)2.11521005
67Prominent occiput (HP:0000269)2.10880523
68Chronic hepatic failure (HP:0100626)2.10788741
69Breast hypoplasia (HP:0003187)2.08404299
70Trigonocephaly (HP:0000243)2.08333999
71Rib fusion (HP:0000902)2.04786526
72Periauricular skin pits (HP:0100277)2.03817812
73Preauricular pit (HP:0004467)2.03817812
74Skin tags (HP:0010609)2.03199904
75Abnormality of the calcaneus (HP:0008364)2.02751807
76Thoracic kyphosis (HP:0002942)2.02318449
77Hypoplastic scapulae (HP:0000882)2.01914965
78Aplasia/Hypoplasia of the scapulae (HP:0006713)2.01914965
79Birth length less than 3rd percentile (HP:0003561)2.01648197
80Broad thumb (HP:0011304)2.01527189
81Abnormality of the anterior horn cell (HP:0006802)1.99769091
82Degeneration of anterior horn cells (HP:0002398)1.99769091
83Fibular aplasia (HP:0002990)1.99633051
84High pitched voice (HP:0001620)1.99447205
85Basal cell carcinoma (HP:0002671)1.99303950
86Skin pits (HP:0100276)1.99247280
87Prominent nose (HP:0000448)1.98558616
88Oligodontia (HP:0000677)1.98545466
89Facial hemangioma (HP:0000329)1.98482568
90Shawl scrotum (HP:0000049)1.97986123
91Chromsome breakage (HP:0040012)1.97879370
92Abnormality of the renal collecting system (HP:0004742)1.97106193
93Missing ribs (HP:0000921)1.95043148
94Duplicated collecting system (HP:0000081)1.94461914
95Increased density of long bones (HP:0006392)1.93686976
96Carpal bone hypoplasia (HP:0001498)1.93486468
97Absent radius (HP:0003974)1.93000813
98Difficulty climbing stairs (HP:0003551)1.92769179
99Partial agenesis of the corpus callosum (HP:0001338)1.90468989
100Increased connective tissue (HP:0009025)1.89873017
101Abdominal situs inversus (HP:0003363)1.89264983
102Abnormality of abdominal situs (HP:0011620)1.89264983
103Preauricular skin tag (HP:0000384)1.89233648
104Broad palm (HP:0001169)1.87843783
105Sparse lateral eyebrow (HP:0005338)1.87811265
106Calf muscle hypertrophy (HP:0008981)1.87419604
107Truncal obesity (HP:0001956)1.86832135
108Supernumerary ribs (HP:0005815)1.86470675
109Gastrointestinal carcinoma (HP:0002672)1.86118937
110Malignant gastrointestinal tract tumors (HP:0006749)1.86118937
111Overlapping toe (HP:0001845)1.83788792
112Pendular nystagmus (HP:0012043)1.83419601
113Short phalanx of the thumb (HP:0009660)1.83237708
114Pelvic girdle muscle weakness (HP:0003749)1.83089914
115Neoplasm of the pancreas (HP:0002894)1.82958225
116Abnormality of the alveolar ridges (HP:0006477)1.82236562
117Sloping forehead (HP:0000340)1.82213629
118Rectal prolapse (HP:0002035)1.81312131
119Acute myeloid leukemia (HP:0004808)1.80405297
120Genu recurvatum (HP:0002816)1.80333810
121Abnormality of the thoracic spine (HP:0100711)1.79969610
122Congenital malformation of the right heart (HP:0011723)1.79600487
123Double outlet right ventricle (HP:0001719)1.79600487
124Muscle hypertrophy of the lower extremities (HP:0008968)1.79365816
125Skull defect (HP:0001362)1.78121739
126Bony spicule pigmentary retinopathy (HP:0007737)1.77087168
127Absent forearm bone (HP:0003953)1.76829412
128Aplasia involving forearm bones (HP:0009822)1.76829412
129Heterotopia (HP:0002282)1.76466394
130Short 5th finger (HP:0009237)1.76140891
131Unilateral renal agenesis (HP:0000122)1.75163374
132Broad phalanges of the hand (HP:0009768)1.74917024
133Cafe-au-lait spot (HP:0000957)1.74890029
134Hypoplastic pelvis (HP:0008839)1.74043865
135Supernumerary bones of the axial skeleton (HP:0009144)1.73979162
136Reticulocytopenia (HP:0001896)1.73931402
137Abnormality of ocular smooth pursuit (HP:0000617)1.73707700
138Progressive muscle weakness (HP:0003323)1.72210312
139Progressive cerebellar ataxia (HP:0002073)1.72116872
140Meningocele (HP:0002435)1.71968015
141Oral leukoplakia (HP:0002745)1.71751845
142Small hand (HP:0200055)1.71307599
143Biliary tract neoplasm (HP:0100574)1.71294778
144Absent thumb (HP:0009777)1.71283967
145Horseshoe kidney (HP:0000085)1.70173419
146Meckel diverticulum (HP:0002245)1.69020195
147Oligodactyly (hands) (HP:0001180)1.68808454
148Facial asymmetry (HP:0000324)1.68765660
149Nephroblastoma (Wilms tumor) (HP:0002667)1.68635131
150Wrist flexion contracture (HP:0001239)1.67434226
151Adenoma sebaceum (HP:0009720)1.67328808
152Angiofibromas (HP:0010615)1.67328808
153Aplasia/Hypoplasia of the sternum (HP:0006714)1.67067518
154Anal stenosis (HP:0002025)1.66596579
155Hypoplastic iliac wings (HP:0002866)1.66425365
156Thickened calvaria (HP:0002684)1.66386117
157Abnormality of the labia majora (HP:0012881)1.66305717
158Vertebral fusion (HP:0002948)1.66182912
159Cerebral aneurysm (HP:0004944)1.65256101
160Hemivertebrae (HP:0002937)1.65006674
161Abnormality of chromosome stability (HP:0003220)1.64546217
162Short thumb (HP:0009778)1.64278099
163Bowel diverticulosis (HP:0005222)1.64245233
164Abnormality of the ileum (HP:0001549)1.63773480
165Short 1st metacarpal (HP:0010034)1.63717916
166Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.63717916
167Abnormality of the distal phalanx of the thumb (HP:0009617)1.63701942
168Clubbing of toes (HP:0100760)1.63430508
169Increased number of teeth (HP:0011069)1.62893568
170Renovascular hypertension (HP:0100817)1.62453361
171Spina bifida occulta (HP:0003298)1.62437985
172Attenuation of retinal blood vessels (HP:0007843)1.62349682
173Squamous cell carcinoma (HP:0002860)1.61960460
174Flared iliac wings (HP:0002869)1.61080117
175Underdeveloped nasal alae (HP:0000430)1.60811874
176Megalocornea (HP:0000485)1.60367887
177Aplasia/Hypoplasia of the earlobes (HP:0009906)1.60187641
178Supernumerary spleens (HP:0009799)1.60072820
179Sandal gap (HP:0001852)1.59911087
180Chromosomal breakage induced by crosslinking agents (HP:0003221)1.59816338
181Duodenal stenosis (HP:0100867)1.59319398
182Small intestinal stenosis (HP:0012848)1.59319398

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.89694435
2BLK4.66393197
3CDC73.86458928
4EEF2K3.19308335
5INSRR3.13709347
6NEK22.97947319
7MAP3K102.67948450
8ZAK2.57563118
9BUB12.52934477
10NEK12.52219435
11TLK12.45402002
12FRK2.35297198
13WEE12.34067723
14BMPR1B2.29758747
15TTK2.21643385
16TRIB32.02158477
17RPS6KB22.01162629
18PKN22.00933562
19TNIK1.94728366
20LATS21.89468721
21BRD41.89127562
22ICK1.82792744
23STK101.73342680
24AKT31.72618021
25CDK71.70289112
26TTN1.65943343
27LATS11.65924478
28WNK11.62521733
29MTOR1.58387239
30MAP3K21.50049856
31CDK41.48824147
32PLK11.47439393
33EPHA21.46072595
34TSSK61.45395386
35OBSCN1.43170835
36SGK21.39606023
37ATR1.38465401
38CHEK11.36732093
39PAK41.34531363
40MAP3K91.34452845
41CAMK41.33313242
42MAP3K81.31935084
43PBK1.31839137
44PLK41.31569539
45RPS6KA41.31026588
46CHEK21.29541087
47TAF11.26259784
48AURKB1.21286465
49PLK21.21096278
50PASK1.19708880
51STK381.17301690
52TAOK31.15601021
53STK31.14564542
54TESK11.14525837
55SCYL21.14146247
56TESK21.13903530
57BRSK21.12725961
58CDK61.10914216
59ALK1.09202591
60SGK2231.02999119
61SGK4941.02999119
62PNCK1.01263832
63PRKD31.00648096
64PTK2B0.98910651
65SRPK10.98048699
66VRK10.97374411
67CDK20.94814112
68PIK3CG0.94218801
69PAK20.93596490
70LRRK20.93350427
71AURKA0.93156138
72WNK40.92901668
73ATM0.92181143
74PLK30.91696280
75DYRK30.91230244
76MKNK10.90800003
77SGK30.89396751
78MARK20.87392857
79STK40.85526157
80BRSK10.84800562
81PDGFRA0.84474238
82TAOK10.84307092
83TGFBR10.82699208
84PDK40.81126063
85PDK30.81126063
86ERN10.78875434
87MAP3K40.77781538
88NUAK10.77130899
89MUSK0.76609562
90MST1R0.75321913
91STK38L0.73939324
92BMX0.71570822
93EIF2AK10.71003425
94MAP3K70.70631074
95CDK10.68496755
96PTK60.68422098
97PAK10.68165540
98DMPK0.68056842
99SIK20.67070227
100TYRO30.66418608
101MAPKAPK30.66172233
102FGFR10.65724283
103MELK0.65650519
104MAP3K60.65534323
105PRKAA10.65177255
106GRK50.62325912
107CAMK1D0.61193042
108RIPK10.60371080
109AKT20.60337982
110TIE10.59714726
111CSNK1E0.59532275
112RPS6KA60.59280659
113WNK30.58414413
114NME20.58254756
115PRKAA20.56465454
116PTK20.55421206
117PHKG10.54133014
118PHKG20.54133014
119STK110.53933321
120SIK10.53445457
121SGK10.53334674
122PIM10.52751996
123CAMK1G0.51887151
124MAP2K30.51402353
125MET0.50966351
126ERBB40.50642940
127NEK60.49977618
128STK160.48778227
129NME10.46498328
130CDK90.46355998
131RPS6KC10.46209911
132RPS6KL10.46209911
133MKNK20.45387773
134KDR0.45119441
135FLT30.42613592
136CSNK2A20.42450079
137STK390.41639681
138RPS6KA10.41510232
139MAPK140.41025105
140CSNK1D0.40897902
141EPHB20.39846204
142PRKDC0.39601680
143PRKCI0.39464978
144MAP3K110.38979231
145STK240.38335401
146MAP4K10.37512230
147ACVR1B0.37406814
148* MAPK10.36705091
149DDR20.36409959
150MAPK80.36386421
151CDC42BPA0.36382817
152PRKG10.35851171
153GSK3B0.35616593
154ILK0.34533216
155AKT10.32786306
156MAPKAPK20.29716924

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.81486595
2RNA transport_Homo sapiens_hsa030133.30209701
3Mismatch repair_Homo sapiens_hsa034303.26698918
4Spliceosome_Homo sapiens_hsa030403.01209439
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97647626
6Cell cycle_Homo sapiens_hsa041102.95145578
7Systemic lupus erythematosus_Homo sapiens_hsa053222.83641731
8Base excision repair_Homo sapiens_hsa034102.51215211
9Alcoholism_Homo sapiens_hsa050342.41148771
10mRNA surveillance pathway_Homo sapiens_hsa030152.34350918
11One carbon pool by folate_Homo sapiens_hsa006702.28373028
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.18477548
13Nucleotide excision repair_Homo sapiens_hsa034202.04428279
14Homologous recombination_Homo sapiens_hsa034402.02874528
15RNA polymerase_Homo sapiens_hsa030201.83674871
16Fatty acid biosynthesis_Homo sapiens_hsa000611.83646988
17Ribosome_Homo sapiens_hsa030101.80409036
18RNA degradation_Homo sapiens_hsa030181.76789188
19p53 signaling pathway_Homo sapiens_hsa041151.76689883
20Fanconi anemia pathway_Homo sapiens_hsa034601.69866482
21Basal cell carcinoma_Homo sapiens_hsa052171.57188312
22MicroRNAs in cancer_Homo sapiens_hsa052061.48485677
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.47755699
24Non-homologous end-joining_Homo sapiens_hsa034501.47306365
25Adherens junction_Homo sapiens_hsa045201.41996817
26Hippo signaling pathway_Homo sapiens_hsa043901.41555498
27Basal transcription factors_Homo sapiens_hsa030221.38445375
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33755220
29Pyrimidine metabolism_Homo sapiens_hsa002401.33516561
30Notch signaling pathway_Homo sapiens_hsa043301.31172075
31Olfactory transduction_Homo sapiens_hsa047401.27828200
32Small cell lung cancer_Homo sapiens_hsa052221.27142292
33Oocyte meiosis_Homo sapiens_hsa041141.26594249
34HTLV-I infection_Homo sapiens_hsa051661.25112547
35Thyroid cancer_Homo sapiens_hsa052161.24134510
36Hedgehog signaling pathway_Homo sapiens_hsa043401.23551004
37Chronic myeloid leukemia_Homo sapiens_hsa052201.22074638
38Taste transduction_Homo sapiens_hsa047421.21082077
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.21048199
40Epstein-Barr virus infection_Homo sapiens_hsa051691.17021642
41mTOR signaling pathway_Homo sapiens_hsa041501.12137660
42Viral carcinogenesis_Homo sapiens_hsa052031.11405068
43Viral myocarditis_Homo sapiens_hsa054161.11161916
44Lysine degradation_Homo sapiens_hsa003101.10224862
45Colorectal cancer_Homo sapiens_hsa052101.09636498
46Proteasome_Homo sapiens_hsa030501.06623023
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05954669
48TGF-beta signaling pathway_Homo sapiens_hsa043501.05506678
49Central carbon metabolism in cancer_Homo sapiens_hsa052301.04312040
50Bladder cancer_Homo sapiens_hsa052190.97171685
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95765088
52Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92837564
53Proteoglycans in cancer_Homo sapiens_hsa052050.92702611
54Ovarian steroidogenesis_Homo sapiens_hsa049130.90195117
55Herpes simplex infection_Homo sapiens_hsa051680.87815297
56Biosynthesis of amino acids_Homo sapiens_hsa012300.87667196
57Calcium signaling pathway_Homo sapiens_hsa040200.85699471
58ErbB signaling pathway_Homo sapiens_hsa040120.85469549
59ABC transporters_Homo sapiens_hsa020100.85069202
60Endometrial cancer_Homo sapiens_hsa052130.84845691
61Acute myeloid leukemia_Homo sapiens_hsa052210.83797093
62Tight junction_Homo sapiens_hsa045300.83775686
63Circadian rhythm_Homo sapiens_hsa047100.83296330
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82965233
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82537957
66Pathways in cancer_Homo sapiens_hsa052000.80724008
67MAPK signaling pathway_Homo sapiens_hsa040100.80027497
68HIF-1 signaling pathway_Homo sapiens_hsa040660.79911341
69Wnt signaling pathway_Homo sapiens_hsa043100.79768672
70Gap junction_Homo sapiens_hsa045400.78811286
71Inositol phosphate metabolism_Homo sapiens_hsa005620.76718294
72Focal adhesion_Homo sapiens_hsa045100.75888945
73Antigen processing and presentation_Homo sapiens_hsa046120.75555587
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74935204
75Cholinergic synapse_Homo sapiens_hsa047250.74825951
76Prostate cancer_Homo sapiens_hsa052150.74158534
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73361031
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73218828
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72904848
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70866744
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69250703
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67726756
83Non-small cell lung cancer_Homo sapiens_hsa052230.66660672
84Pancreatic cancer_Homo sapiens_hsa052120.66203600
85Type II diabetes mellitus_Homo sapiens_hsa049300.65876319
86Nicotine addiction_Homo sapiens_hsa050330.65863255
87Renal cell carcinoma_Homo sapiens_hsa052110.65514752
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.65312237
89ECM-receptor interaction_Homo sapiens_hsa045120.64855539
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64456195
91VEGF signaling pathway_Homo sapiens_hsa043700.61280540
92Hepatitis B_Homo sapiens_hsa051610.60646344
93Cardiac muscle contraction_Homo sapiens_hsa042600.59878868
94Purine metabolism_Homo sapiens_hsa002300.59422069
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59412881
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59209059
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58317515
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56935374
99AMPK signaling pathway_Homo sapiens_hsa041520.56439535
100Apoptosis_Homo sapiens_hsa042100.55900751
101Glutamatergic synapse_Homo sapiens_hsa047240.55492426
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54807095
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54733890
104Axon guidance_Homo sapiens_hsa043600.54482499
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.53856837
106Estrogen signaling pathway_Homo sapiens_hsa049150.53755469
107Shigellosis_Homo sapiens_hsa051310.53560588
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52958210
109Pentose phosphate pathway_Homo sapiens_hsa000300.52921962
110Melanogenesis_Homo sapiens_hsa049160.52729658
111Platelet activation_Homo sapiens_hsa046110.52331307
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52098543
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.51463391
114Morphine addiction_Homo sapiens_hsa050320.50569524
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50178631
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50027350
117Melanoma_Homo sapiens_hsa052180.49997149
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.49234817
119cAMP signaling pathway_Homo sapiens_hsa040240.48647513
120Oxytocin signaling pathway_Homo sapiens_hsa049210.48218962
121Prolactin signaling pathway_Homo sapiens_hsa049170.48029478
122Selenocompound metabolism_Homo sapiens_hsa004500.47647606
123Dorso-ventral axis formation_Homo sapiens_hsa043200.47269506
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.47187952
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.46520058
126FoxO signaling pathway_Homo sapiens_hsa040680.46329114
127Carbon metabolism_Homo sapiens_hsa012000.44757069
128Dilated cardiomyopathy_Homo sapiens_hsa054140.43907910
129Insulin signaling pathway_Homo sapiens_hsa049100.43901764
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42749781
131Glioma_Homo sapiens_hsa052140.41752131
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41280597
133Legionellosis_Homo sapiens_hsa051340.40684674
134Glucagon signaling pathway_Homo sapiens_hsa049220.38128528
135Insulin resistance_Homo sapiens_hsa049310.36056175
136Toxoplasmosis_Homo sapiens_hsa051450.35609886

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