UBASH3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.90556957
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.90556957
3positive regulation of gamma-delta T cell activation (GO:0046645)5.62928560
4negative T cell selection (GO:0043383)5.36594454
5negative thymic T cell selection (GO:0045060)5.11286292
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.90961232
7antigen processing and presentation of endogenous antigen (GO:0019883)4.86648977
8ribosomal small subunit assembly (GO:0000028)4.81716028
9regulation of gamma-delta T cell differentiation (GO:0045586)4.61929799
10leukocyte aggregation (GO:0070486)4.38842228
11negative regulation of cell killing (GO:0031342)4.36785458
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.36785458
13positive thymic T cell selection (GO:0045059)4.34436025
14negative regulation of lymphocyte mediated immunity (GO:0002707)4.20984610
15interferon-gamma production (GO:0032609)4.19147243
16thymic T cell selection (GO:0045061)4.17281816
17positive T cell selection (GO:0043368)4.15302265
18regulation of gamma-delta T cell activation (GO:0046643)4.15107715
19response to interleukin-15 (GO:0070672)4.09957253
20T cell selection (GO:0045058)4.03387185
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.02195188
22regulation of isotype switching to IgG isotypes (GO:0048302)3.92347079
23T cell migration (GO:0072678)3.90232190
24viral transcription (GO:0019083)3.85939198
25negative regulation of leukocyte mediated immunity (GO:0002704)3.83567500
26regulation of tolerance induction (GO:0002643)3.80971140
27DNA deamination (GO:0045006)3.76946468
28telomere maintenance via semi-conservative replication (GO:0032201)3.73574946
29translational termination (GO:0006415)3.71425859
30cellular response to interleukin-15 (GO:0071350)3.71067497
31regulation of T cell mediated cytotoxicity (GO:0001914)3.69220955
32DNA strand elongation involved in DNA replication (GO:0006271)3.66689360
33alpha-beta T cell differentiation (GO:0046632)3.61527048
34T cell receptor signaling pathway (GO:0050852)3.58857057
35DNA strand elongation (GO:0022616)3.51820003
36positive regulation of T cell mediated cytotoxicity (GO:0001916)3.49826788
37mast cell activation (GO:0045576)3.49581349
38regulation of leukocyte mediated cytotoxicity (GO:0001910)3.45954440
39positive regulation of T cell differentiation in thymus (GO:0033089)3.45004617
40DNA unwinding involved in DNA replication (GO:0006268)3.41079405
41positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.37095991
42translational elongation (GO:0006414)3.33773717
43alpha-beta T cell activation (GO:0046631)3.30359005
44lymphocyte migration (GO:0072676)3.29817454
45regulation of T cell tolerance induction (GO:0002664)3.28907634
46T cell costimulation (GO:0031295)3.28559700
47T cell homeostasis (GO:0043029)3.28024078
48regulation of B cell receptor signaling pathway (GO:0050855)3.27488539
49negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.27120423
50cellular response to type I interferon (GO:0071357)3.27028071
51type I interferon signaling pathway (GO:0060337)3.27028071
52mucosal-associated lymphoid tissue development (GO:0048537)3.26953313
53Peyers patch development (GO:0048541)3.26953313
54response to type I interferon (GO:0034340)3.25662812
55positive regulation of humoral immune response (GO:0002922)3.24633076
56maturation of SSU-rRNA (GO:0030490)3.23689784
57SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.23637455
58ribosomal small subunit biogenesis (GO:0042274)3.23524545
59lymphocyte costimulation (GO:0031294)3.23005578
60telomere maintenance via recombination (GO:0000722)3.21710196
61antigen processing and presentation via MHC class Ib (GO:0002475)3.21064167
62DNA replication initiation (GO:0006270)3.20228098
63regulation of cell killing (GO:0031341)3.19754307
64antigen receptor-mediated signaling pathway (GO:0050851)3.18927668
65regulation of interleukin-2 biosynthetic process (GO:0045076)3.18552214
66negative regulation of T cell apoptotic process (GO:0070233)3.18216811
67tolerance induction (GO:0002507)3.17121878
68cotranslational protein targeting to membrane (GO:0006613)3.15449177
69regulation of alpha-beta T cell activation (GO:0046634)3.14243532
70regulation of alpha-beta T cell proliferation (GO:0046640)3.13481838
71protein targeting to ER (GO:0045047)3.13406334
72Arp2/3 complex-mediated actin nucleation (GO:0034314)3.11862039
73negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.11266713
74CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.10887123
75T-helper cell differentiation (GO:0042093)3.10887123
76detection of bacterium (GO:0016045)3.09602059
77regulation of granulocyte differentiation (GO:0030852)3.07967881
78positive regulation of cell killing (GO:0031343)3.07540910
79negative regulation of interleukin-12 production (GO:0032695)3.06111893
80nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.06027295
81positive regulation of isotype switching (GO:0045830)3.05609792
82positive regulation of B cell differentiation (GO:0045579)3.04701736
83mitotic recombination (GO:0006312)3.03961170
84dendritic cell chemotaxis (GO:0002407)3.03758957
85detection of other organism (GO:0098543)3.03756192
86positive regulation of interleukin-4 production (GO:0032753)3.03708937
87negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.03057405
88negative regulation of phagocytosis (GO:0050765)3.02548460
89establishment of protein localization to endoplasmic reticulum (GO:0072599)2.97844998
90positive regulation by symbiont of host defense response (GO:0052509)2.97371994
91modulation by symbiont of host defense response (GO:0052031)2.97371994
92modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.97371994
93modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.97371994
94positive regulation by organism of defense response of other organism involved in symbiotic interact2.97371994
95modulation by symbiont of host immune response (GO:0052553)2.97371994
96CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.96770511
97response to muramyl dipeptide (GO:0032495)2.96739259
98protein localization to endoplasmic reticulum (GO:0070972)2.95552122
99regulation of B cell differentiation (GO:0045577)2.95115625
100V(D)J recombination (GO:0033151)2.95027177
101negative regulation of innate immune response (GO:0045824)2.93141907
102cellular extravasation (GO:0045123)2.92920938
103positive regulation of alpha-beta T cell proliferation (GO:0046641)2.92652807
104positive regulation of tolerance induction (GO:0002645)2.92158976
105regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.91918123
106regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.88850453
107positive regulation of interleukin-2 production (GO:0032743)2.87886730
108positive regulation of granulocyte differentiation (GO:0030854)2.87598078
109cellular protein complex disassembly (GO:0043624)2.87248185
110cellular response to interleukin-4 (GO:0071353)2.86428588
111viral life cycle (GO:0019058)2.86413090
112* regulation of T cell receptor signaling pathway (GO:0050856)2.84791598
113translational initiation (GO:0006413)2.84658925
114regulation of isotype switching (GO:0045191)2.84558437
115* regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.81663872
116T cell differentiation (GO:0030217)2.79675673
117regulation of response to interferon-gamma (GO:0060330)2.75622208
118telomere maintenance via telomere lengthening (GO:0010833)2.75064056
119mast cell degranulation (GO:0043303)2.73550173
120mast cell activation involved in immune response (GO:0002279)2.73550173
121regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.72398250
122DNA replication checkpoint (GO:0000076)2.71528838
123antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.70150753
124nucleotide-excision repair, DNA gap filling (GO:0006297)2.68234854
125NIK/NF-kappaB signaling (GO:0038061)2.65910140
126positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.65861262
127lymphocyte homeostasis (GO:0002260)2.65328332
128regulation of natural killer cell mediated immunity (GO:0002715)2.63433646
129regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.63433646
130negative regulation of T cell mediated immunity (GO:0002710)2.63264836
131regulation of regulatory T cell differentiation (GO:0045589)2.61174473
132positive regulation of natural killer cell mediated immunity (GO:0002717)2.60770357
133positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.60770357
134protein localization to kinetochore (GO:0034501)2.59337039
135protein complex disassembly (GO:0043241)2.58978824
136activated T cell proliferation (GO:0050798)2.58485345
137regulation of protein heterodimerization activity (GO:0043497)2.58382924
138T cell activation (GO:0042110)2.56554528
139B cell receptor signaling pathway (GO:0050853)2.55331437
140positive regulation of DNA recombination (GO:0045911)2.54635046
141regulation of B cell mediated immunity (GO:0002712)2.54595809
142response to interleukin-4 (GO:0070670)2.54327258

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.73243679
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.70690877
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.38823422
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.26557460
5MYC_22102868_ChIP-Seq_BL_Human2.92826806
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.76819082
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.69002143
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.67240858
9SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.65423637
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.65161616
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.59946762
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.58224144
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.53148236
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.47047260
15VDR_21846776_ChIP-Seq_THP-1_Human2.35068204
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.33695777
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.28702828
18MYB_26560356_Chip-Seq_TH2_Human2.27917076
19* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.10057179
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08892567
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05216723
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.04766716
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02981999
24* SCL_19346495_ChIP-Seq_HPC-7_Human2.02172023
25* MAF_26560356_Chip-Seq_TH1_Human2.00253018
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.98137205
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.96997241
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.95927151
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.95167327
30VDR_23849224_ChIP-Seq_CD4+_Human1.94876079
31UTX_26944678_Chip-Seq_JUKART_Human1.93795192
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.93476190
33GATA3_26560356_Chip-Seq_TH2_Human1.93343769
34MYB_26560356_Chip-Seq_TH1_Human1.93214498
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.90996056
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.85738592
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.85689803
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.85597948
39SPI1_23547873_ChIP-Seq_NB4_Human1.85045766
40RUNX_20019798_ChIP-Seq_JUKART_Human1.81731719
41SPI1_23127762_ChIP-Seq_K562_Human1.80982562
42CIITA_25753668_ChIP-Seq_RAJI_Human1.80606305
43FOXP3_21729870_ChIP-Seq_TREG_Human1.80102552
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79571966
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.78482777
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.73727913
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.73624507
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72849446
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72760371
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.70183446
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.68531167
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.65817641
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64517123
54XRN2_22483619_ChIP-Seq_HELA_Human1.63673653
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.62837250
56* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.58887732
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58715488
58RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.57363293
59VDR_24763502_ChIP-Seq_THP-1_Human1.56771743
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.56734034
61KDM2B_26808549_Chip-Seq_DND41_Human1.53371741
62HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.52082351
63MAF_26560356_Chip-Seq_TH2_Human1.49748028
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.48306836
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43256201
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42946285
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40525469
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.39683028
69BP1_19119308_ChIP-ChIP_Hs578T_Human1.35947141
70* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34564511
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33168697
72GATA1_22025678_ChIP-Seq_K562_Human1.33003723
73NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31988790
74TCF7_22412390_ChIP-Seq_EML_Mouse1.31509119
75GABP_19822575_ChIP-Seq_HepG2_Human1.31103056
76ELK1_19687146_ChIP-ChIP_HELA_Human1.30826523
77* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29889933
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28941280
79DCP1A_22483619_ChIP-Seq_HELA_Human1.28556161
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26738605
81* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23644310
82* GATA3_27048872_Chip-Seq_THYMUS_Human1.23020861
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.22688799
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22255734
85GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22091036
86SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21079262
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17476047
88KDM2B_26808549_Chip-Seq_JURKAT_Human1.16852532
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15181658
90VDR_24787735_ChIP-Seq_THP-1_Human1.13236263
91TTF2_22483619_ChIP-Seq_HELA_Human1.12397441
92GATA1_19941826_ChIP-Seq_K562_Human1.10583491
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10483556
94CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10273194
95PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09943861
96CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09898488
97E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09102937
98BCL6_27268052_Chip-Seq_Bcells_Human1.08794107
99NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08267167
100KDM5A_27292631_Chip-Seq_BREAST_Human1.08161843
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07435137
102IRF8_27001747_Chip-Seq_BMDM_Mouse1.07387563
103KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07034478
104CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06638131
105PU_27001747_Chip-Seq_BMDM_Mouse1.06395772
106LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05445224
107* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04515101
108PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03865175
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03071864
110PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02928830
111HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01890508
112AR_21909140_ChIP-Seq_LNCAP_Human1.01302345
113CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01001423
114MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00358103
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00246437
116MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99896052
117THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98256086
118MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98229115
119SRF_21415370_ChIP-Seq_HL-1_Mouse0.97856825
120ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97465809
121PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96077792
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95532395
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94886509
124LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94608266
125YY1_21170310_ChIP-Seq_MESCs_Mouse0.94396233
126SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94019376
127* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93682318
128BCOR_27268052_Chip-Seq_Bcells_Human0.93458380
129ELK3_25401928_ChIP-Seq_HUVEC_Human0.93354861
130RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93172230
131VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93066917
132YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92280050
133* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88958805
134* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87832174
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87354164
136ELF1_20517297_ChIP-Seq_JURKAT_Human0.85966656
137PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84803168
138Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82408982
139GATA3_26560356_Chip-Seq_TH1_Human0.81165379
140THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79232718
141* GATA2_19941826_ChIP-Seq_K562_Human0.77078651
142P300_27268052_Chip-Seq_Bcells_Human0.76723033

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.79418617
2MP0005671_abnormal_response_to3.79580335
3MP0002396_abnormal_hematopoietic_system3.70307836
4MP0001835_abnormal_antigen_presentation3.06863669
5MP0000685_abnormal_immune_system2.95996112
6MP0009333_abnormal_splenocyte_physiolog2.87863762
7MP0002166_altered_tumor_susceptibility2.83478034
8MP0002398_abnormal_bone_marrow2.77642644
9MP0003693_abnormal_embryo_hatching2.64049676
10MP0001800_abnormal_humoral_immune2.63743908
11MP0009785_altered_susceptibility_to2.54979475
12MP0002420_abnormal_adaptive_immunity2.52453310
13MP0008057_abnormal_DNA_replication2.52042271
14MP0010094_abnormal_chromosome_stability2.49446525
15MP0000703_abnormal_thymus_morphology2.48298280
16MP0001819_abnormal_immune_cell2.48125810
17MP0005000_abnormal_immune_tolerance2.40477827
18MP0002723_abnormal_immune_serum2.34819915
19MP0002722_abnormal_immune_system2.33877743
20MP0005025_abnormal_response_to2.31162191
21MP0000716_abnormal_immune_system2.30948640
22MP0002006_tumorigenesis2.29712619
23MP0000689_abnormal_spleen_morphology2.25962777
24MP0002452_abnormal_antigen_presenting2.21204491
25MP0002405_respiratory_system_inflammati2.20504144
26MP0003436_decreased_susceptibility_to2.20223524
27MP0003724_increased_susceptibility_to2.14047435
28MP0001790_abnormal_immune_system2.11575704
29MP0005387_immune_system_phenotype2.11575704
30MP0002429_abnormal_blood_cell2.04823514
31MP0001873_stomach_inflammation2.04411246
32MP0003077_abnormal_cell_cycle2.03511998
33MP0001545_abnormal_hematopoietic_system2.02138307
34MP0005397_hematopoietic_system_phenotyp2.02138307
35MP0003111_abnormal_nucleus_morphology2.01141509
36MP0005075_abnormal_melanosome_morpholog1.96205189
37MP0005464_abnormal_platelet_physiology1.95555533
38MP0004808_abnormal_hematopoietic_stem1.93810661
39MP0010155_abnormal_intestine_physiology1.92431228
40MP0000490_abnormal_crypts_of1.91598508
41MP0004957_abnormal_blastocyst_morpholog1.90637126
42MP0003866_abnormal_defecation1.86557163
43MP0002419_abnormal_innate_immunity1.84188986
44MP0002148_abnormal_hypersensitivity_rea1.78239261
45MP0001853_heart_inflammation1.62065253
46MP0000465_gastrointestinal_hemorrhage1.60828088
47MP0008058_abnormal_DNA_repair1.60563784
48MP0000858_altered_metastatic_potential1.58934188
49MP0006082_CNS_inflammation1.58495455
50MP0003300_gastrointestinal_ulcer1.57602881
51MP0008007_abnormal_cellular_replicative1.51018577
52MP0001845_abnormal_inflammatory_respons1.49468198
53MP0002019_abnormal_tumor_incidence1.49392508
54MP0004947_skin_inflammation1.48665271
55MP0003303_peritoneal_inflammation1.43653398
56MP0010352_gastrointestinal_tract_polyps1.38630814
57MP0002933_joint_inflammation1.34171342
58MP0002132_abnormal_respiratory_system1.32047748
59MP0003191_abnormal_cellular_cholesterol1.28058322
60MP0005174_abnormal_tail_pigmentation1.22300255
61MP0004381_abnormal_hair_follicle1.21706998
62MP0003045_fibrosis1.16645562
63MP0003656_abnormal_erythrocyte_physiolo1.16581876
64MP0006054_spinal_hemorrhage1.12973800
65MP0002277_abnormal_respiratory_mucosa1.06743576
66MP0008469_abnormal_protein_level1.06676204
67MP0000350_abnormal_cell_proliferation0.97729027
68MP0003828_pulmonary_edema0.97723001
69MP0000313_abnormal_cell_death0.97142756
70MP0002998_abnormal_bone_remodeling0.95256678
71MP0003448_altered_tumor_morphology0.93545870
72MP0001533_abnormal_skeleton_physiology0.93224369
73MP0005451_abnormal_body_composition0.92621714
74MP0002095_abnormal_skin_pigmentation0.84743146
75MP0004883_abnormal_blood_vessel0.83596144
76MP0008260_abnormal_autophagy0.82239783
77MP0002009_preneoplasia0.81831037
78MP0009278_abnormal_bone_marrow0.80530899
79MP0004130_abnormal_muscle_cell0.79992569
80MP0010307_abnormal_tumor_latency0.78606399
81MP0001730_embryonic_growth_arrest0.78451626
82MP0003786_premature_aging0.77086130
83MP0009763_increased_sensitivity_to0.73849104
84MP0001851_eye_inflammation0.72566224
85MP0002138_abnormal_hepatobiliary_system0.70133257
86MP0000015_abnormal_ear_pigmentation0.69421049
87MP0005166_decreased_susceptibility_to0.67952491
88MP0005310_abnormal_salivary_gland0.67772489
89MP0000477_abnormal_intestine_morphology0.67373797
90MP0004510_myositis0.65552802
91MP0005023_abnormal_wound_healing0.64811563
92MP0005390_skeleton_phenotype0.63883766
93MP0008961_abnormal_basal_metabolism0.63584314
94MP0001663_abnormal_digestive_system0.63200033
95MP0003172_abnormal_lysosome_physiology0.63125313
96MP0002693_abnormal_pancreas_physiology0.62603928
97MP0000604_amyloidosis0.61613297
98MP0009765_abnormal_xenobiotic_induced0.60579812
99MP0008932_abnormal_embryonic_tissue0.58499098
100MP0008873_increased_physiological_sensi0.57836805
101MP0008877_abnormal_DNA_methylation0.57813748
102MP0002080_prenatal_lethality0.57475620
103MP0002163_abnormal_gland_morphology0.56925383
104MP0003186_abnormal_redox_activity0.56416507
105MP0000371_diluted_coat_color0.56176124
106MP0004147_increased_porphyrin_level0.56033812
107MP0003795_abnormal_bone_structure0.55417562
108MP0005076_abnormal_cell_differentiation0.54793380
109MP0003690_abnormal_glial_cell0.54533063
110MP0000249_abnormal_blood_vessel0.54329281
111MP0001919_abnormal_reproductive_system0.52585292
112MP0005164_abnormal_response_to0.52098023
113MP0000343_altered_response_to0.51185535
114MP0001348_abnormal_lacrimal_gland0.48101414
115MP0000609_abnormal_liver_physiology0.48012889
116MP0000358_abnormal_cell_content/0.46642033
117MP0002086_abnormal_extraembryonic_tissu0.46563674
118MP0000598_abnormal_liver_morphology0.46333647
119MP0002970_abnormal_white_adipose0.45724550
120MP0009764_decreased_sensitivity_to0.45612913
121MP0002136_abnormal_kidney_physiology0.45473401
122MP0001986_abnormal_taste_sensitivity0.45158527
123MP0001501_abnormal_sleep_pattern0.44944351
124MP0001697_abnormal_embryo_size0.44220199
125MP0001765_abnormal_ion_homeostasis0.41784830
126MP0009840_abnormal_foam_cell0.39716684
127MP0005083_abnormal_biliary_tract0.39514850
128MP0008874_decreased_physiological_sensi0.36769669
129MP0003252_abnormal_bile_duct0.34796994
130MP0004185_abnormal_adipocyte_glucose0.34220507
131MP0008995_early_reproductive_senescence0.34054291
132MP0005381_digestive/alimentary_phenotyp0.34009955

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.61933142
2Abnormality of T cell number (HP:0011839)5.35530308
3Elevated erythrocyte sedimentation rate (HP:0003565)4.92827848
4Chronic otitis media (HP:0000389)4.90697616
5Abnormality of T cells (HP:0002843)4.53336714
6IgM deficiency (HP:0002850)4.43911883
7Severe combined immunodeficiency (HP:0004430)4.38269732
8Gastrointestinal infarctions (HP:0005244)4.30308589
9Abnormal number of erythroid precursors (HP:0012131)4.29202057
10Recurrent viral infections (HP:0004429)4.23164556
11Combined immunodeficiency (HP:0005387)4.19590822
12Abnormality of cells of the erythroid lineage (HP:0012130)4.18450051
13Recurrent bronchitis (HP:0002837)4.16037419
14Panhypogammaglobulinemia (HP:0003139)4.14462576
15Orchitis (HP:0100796)4.07137558
16Recurrent fungal infections (HP:0002841)4.01503472
17Thrombocytosis (HP:0001894)3.89219004
18Abnormality of macrophages (HP:0004311)3.86132605
19Nasal polyposis (HP:0100582)3.73030653
20IgG deficiency (HP:0004315)3.67107256
21Abnormality of B cell number (HP:0010975)3.60817513
22B lymphocytopenia (HP:0010976)3.60817513
23Aplastic anemia (HP:0001915)3.48120102
24Myositis (HP:0100614)3.47743302
25Reticulocytopenia (HP:0001896)3.45482763
26Abnormality of T cell physiology (HP:0011840)3.44515584
27Hypoplasia of the thymus (HP:0000778)3.39000436
28Eosinophilia (HP:0001880)3.34670299
29Stomatitis (HP:0010280)3.34254139
30Chronic mucocutaneous candidiasis (HP:0002728)3.30118218
31Recurrent cutaneous fungal infections (HP:0011370)3.30118218
32Abnormality of eosinophils (HP:0001879)3.29726153
33Eczematoid dermatitis (HP:0000976)3.25322312
34Granulocytopenia (HP:0001913)3.21673416
35Petechiae (HP:0000967)3.17560976
36Abnormal delayed hypersensitivity skin test (HP:0002963)3.17371491
37Chest pain (HP:0100749)3.09615155
38Abnormality of the nasal mucosa (HP:0000433)3.07562356
39Recurrent abscess formation (HP:0002722)3.04876926
40Lymphoma (HP:0002665)3.04081359
41Meningitis (HP:0001287)2.99482979
42Thyroiditis (HP:0100646)2.99143966
43Lymphopenia (HP:0001888)2.98175685
44Leukocytosis (HP:0001974)2.96801941
45Keratoconjunctivitis sicca (HP:0001097)2.96370789
46Abnormality of cells of the lymphoid lineage (HP:0012140)2.94469890
47Abnormality of the fingertips (HP:0001211)2.87400232
48Hypochromic anemia (HP:0001931)2.84555611
49Keratoconjunctivitis (HP:0001096)2.84033946
50Papilledema (HP:0001085)2.78985830
51Recurrent gram-negative bacterial infections (HP:0005420)2.76835948
52Prolonged bleeding time (HP:0003010)2.75623873
53Gingivitis (HP:0000230)2.73425231
54Autoimmune hemolytic anemia (HP:0001890)2.71413416
55Pustule (HP:0200039)2.69952291
56Basal cell carcinoma (HP:0002671)2.67892044
57Hypochromic microcytic anemia (HP:0004840)2.66907977
58Abnormality of the prostate (HP:0008775)2.66603165
59Mediastinal lymphadenopathy (HP:0100721)2.64158692
60Pulmonary embolism (HP:0002204)2.58451631
61Chronic diarrhea (HP:0002028)2.56261686
62Chronic obstructive pulmonary disease (HP:0006510)2.55575323
63Obstructive lung disease (HP:0006536)2.55575323
64Colitis (HP:0002583)2.53761924
65Epistaxis (HP:0000421)2.52137619
66Stomach cancer (HP:0012126)2.44749313
67Pallor (HP:0000980)2.43771093
68Recurrent skin infections (HP:0001581)2.39813246
69Recurrent bacterial skin infections (HP:0005406)2.38888205
70Anorexia (HP:0002039)2.38516092
71Arterial thrombosis (HP:0004420)2.37573498
72Encephalitis (HP:0002383)2.37473543
73Autoimmune thrombocytopenia (HP:0001973)2.36343042
74Urticaria (HP:0001025)2.34406668
75Joint swelling (HP:0001386)2.32321386
76Acute hepatic failure (HP:0006554)2.30982391
77Bronchitis (HP:0012387)2.30846518
78Hemoptysis (HP:0002105)2.28790233
79Abnormal platelet volume (HP:0011876)2.26324697
80Microcytic anemia (HP:0001935)2.25837382
81Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.25243575
82Agammaglobulinemia (HP:0004432)2.24576134
83Reduced antithrombin III activity (HP:0001976)2.24574384
84Poikiloderma (HP:0001029)2.24409499
85Gangrene (HP:0100758)2.24035308
86Chronic sinusitis (HP:0011109)2.22590227
87Myelodysplasia (HP:0002863)2.21877965
88Gingival bleeding (HP:0000225)2.21517187
89Episodic fever (HP:0001954)2.21340922
90Pancytopenia (HP:0001876)2.21337016
91IgA deficiency (HP:0002720)2.21081429
92Hypergammaglobulinemia (HP:0010702)2.18863689
93Vasculitis (HP:0002633)2.18440462
94Macrocytic anemia (HP:0001972)2.17959123
95Spontaneous hematomas (HP:0007420)2.17901238
96Glomerulopathy (HP:0100820)2.17162895
97Abnormality of the heme biosynthetic pathway (HP:0010472)2.15879439
98Aplasia/Hypoplasia of the thymus (HP:0010515)2.12849954
9911 pairs of ribs (HP:0000878)2.10234093
100Birth length less than 3rd percentile (HP:0003561)2.09066020
101Recurrent sinusitis (HP:0011108)2.08614683
102Amaurosis fugax (HP:0100576)2.07910821
103Gastrointestinal inflammation (HP:0004386)2.07082311
104Chromsome breakage (HP:0040012)2.04978944
105Slow saccadic eye movements (HP:0000514)2.03366554
106Abnormality of DNA repair (HP:0003254)2.02270882
107Abnormality of chromosome stability (HP:0003220)2.01235328
108Inflammation of the large intestine (HP:0002037)2.00619245
109Abnormality of the pleura (HP:0002103)1.99928849
110Sepsis (HP:0100806)1.99659663
111Keratitis (HP:0000491)1.98724769
112Increased IgM level (HP:0003496)1.98437619
113Hematochezia (HP:0002573)1.97276857
114Pulmonary infiltrates (HP:0002113)1.97167996
115Abnormal platelet function (HP:0011869)1.96632453
116Impaired platelet aggregation (HP:0003540)1.96632453
117Pulmonary fibrosis (HP:0002206)1.96017740
118Oral leukoplakia (HP:0002745)1.95145674
119Type I transferrin isoform profile (HP:0003642)1.94834903
120Papilloma (HP:0012740)1.94196083
121Verrucae (HP:0200043)1.94196083
122Cellulitis (HP:0100658)1.93217040
123Neutropenia (HP:0001875)1.93077400
124Hypoproteinemia (HP:0003075)1.91428936
125Bone marrow hypocellularity (HP:0005528)1.90654680
126Increased IgE level (HP:0003212)1.89086611
127Optic neuritis (HP:0100653)1.88913630
128Retrobulbar optic neuritis (HP:0100654)1.88913630
129Cellular immunodeficiency (HP:0005374)1.87871568
130Skin ulcer (HP:0200042)1.85960459
131Osteomyelitis (HP:0002754)1.80225568
132Hemiplegia (HP:0002301)1.80133478
133Polyneuropathy (HP:0001271)1.79101532

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.04359449
2TXK4.57225853
3RIPK42.95825775
4ZAP702.64975024
5ITK2.60989136
6JAK32.56145875
7STK102.54045958
8EEF2K2.38728392
9CDC72.32629991
10TEC2.21458541
11PRPF4B2.18726248
12TYK22.18182827
13NME22.12779773
14GRK61.88934153
15IKBKE1.88364451
16BTK1.88218757
17STK161.84840004
18CLK11.73077852
19FGFR41.72797513
20KIT1.71539919
21CAMKK21.66676221
22WEE11.64228553
23SIK31.63976125
24EPHB11.59156173
25TESK21.57490211
26LCK1.56483608
27NLK1.54465229
28SYK1.53973505
29ACVR1B1.50600226
30FLT31.50271898
31MAP3K101.45452423
32KDR1.39047089
33LRRK21.33328807
34TBK11.32893106
35JAK11.32828564
36BLK1.31574220
37PIM21.31129622
38CAMKK11.30363764
39PKN21.29433925
40RPS6KA41.25046187
41PIM11.23272248
42IRAK41.20293368
43MAP3K141.17652062
44BUB11.12770444
45HCK1.11163052
46NEK21.10252379
47CSK1.09486782
48FGFR31.07754746
49MST41.06773672
50CDK41.05242687
51ERN11.04211666
52TSSK61.03874157
53EIF2AK11.02872605
54PASK1.02290869
55MAP2K20.99508986
56ATR0.99451022
57VRK10.98639176
58RPS6KB20.98508977
59MAP2K30.97539819
60CSF1R0.95321157
61SRPK10.93151410
62FES0.91734010
63STK40.89707756
64SCYL20.89507007
65TGFBR10.88802435
66EPHA30.87890142
67LYN0.85410262
68EIF2AK30.84652445
69MAP3K10.84300718
70MAP3K30.79938065
71IKBKB0.79858281
72TAOK30.79327728
73JAK20.74409295
74FGR0.73947893
75MAP3K80.72543347
76BRSK20.72381801
77MAPK70.72329293
78TNK20.70867971
79TLK10.68799017
80CDK70.66963928
81PRKCQ0.66225797
82PDK10.64566675
83MAPK120.64243900
84TYRO30.63280184
85MARK20.60865538
86AURKB0.60548609
87MAP3K120.60281118
88BMPR20.60270709
89FYN0.59188616
90MAPK40.55210413
91MARK30.53760505
92NEK60.50993532
93MAPK110.50753044
94MAP3K70.50118820
95PLK10.49665695
96DAPK10.47707142
97MAP3K110.47311855
98RPS6KA60.47046341
99TRIB30.46191673
100CCNB10.45123060
101SIK10.45101359
102RAF10.44592204
103CDK120.43697946
104PTK60.43452445
105PTK2B0.43401096
106CDC42BPA0.42834406
107CHEK10.42534246
108CDK60.42237942
109PRKCH0.41978282
110IRAK10.40905919
111TAOK10.40756401
112CDK190.40204056
113MAP3K130.39781948
114PIK3CG0.39641687
115DYRK30.39543081
116STK380.37217931
117GRK70.37132090
118HIPK20.35919371
119RPS6KL10.35330090
120RPS6KC10.35330090
121SMG10.35260439
122CHUK0.34928382
123PDGFRB0.34879420
124ATM0.33967705
125BRSK10.33939699
126RPS6KA50.33374192
127PRKD20.32614377
128TRPM70.31155742
129SIK20.31106869
130CSNK2A20.31047093
131MELK0.30919504
132MAPKAPK20.30884896
133YES10.30836305
134CAMK40.30711087
135MATK0.29508359
136MAP2K60.29118900
137RET0.29111807
138MAPK30.27960707
139TAOK20.27679511
140STK110.26508691

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.55765003
2DNA replication_Homo sapiens_hsa030304.25578308
3Ribosome_Homo sapiens_hsa030103.13742619
4Mismatch repair_Homo sapiens_hsa034303.03068776
5Base excision repair_Homo sapiens_hsa034102.45912830
6T cell receptor signaling pathway_Homo sapiens_hsa046602.43842787
7Homologous recombination_Homo sapiens_hsa034402.25523020
8Measles_Homo sapiens_hsa051622.23547625
9Antigen processing and presentation_Homo sapiens_hsa046122.21460464
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.16409673
11Non-homologous end-joining_Homo sapiens_hsa034502.14730948
12Spliceosome_Homo sapiens_hsa030402.13775223
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.10931882
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.89120520
15Hematopoietic cell lineage_Homo sapiens_hsa046401.88191146
16Nucleotide excision repair_Homo sapiens_hsa034201.88021305
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85683854
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.85583869
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.84191257
20Allograft rejection_Homo sapiens_hsa053301.74596732
21Herpes simplex infection_Homo sapiens_hsa051681.66863624
22Pyrimidine metabolism_Homo sapiens_hsa002401.63206436
23One carbon pool by folate_Homo sapiens_hsa006701.60280313
24Proteasome_Homo sapiens_hsa030501.59372099
25Leishmaniasis_Homo sapiens_hsa051401.56601405
26Cell cycle_Homo sapiens_hsa041101.56182122
27Fanconi anemia pathway_Homo sapiens_hsa034601.51897194
28RNA transport_Homo sapiens_hsa030131.45920887
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43081371
30Graft-versus-host disease_Homo sapiens_hsa053321.42006880
31RNA polymerase_Homo sapiens_hsa030201.40004193
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33039728
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.28010394
34RNA degradation_Homo sapiens_hsa030181.23787051
35Osteoclast differentiation_Homo sapiens_hsa043801.19736547
36B cell receptor signaling pathway_Homo sapiens_hsa046621.19218300
37Autoimmune thyroid disease_Homo sapiens_hsa053201.14750750
38p53 signaling pathway_Homo sapiens_hsa041151.10244718
39Hepatitis B_Homo sapiens_hsa051611.09832686
40Viral myocarditis_Homo sapiens_hsa054161.09646033
41Epstein-Barr virus infection_Homo sapiens_hsa051691.06741645
42Acute myeloid leukemia_Homo sapiens_hsa052211.04237740
43Pentose phosphate pathway_Homo sapiens_hsa000301.00673754
44HTLV-I infection_Homo sapiens_hsa051660.99784394
45Asthma_Homo sapiens_hsa053100.96057409
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92730588
47Viral carcinogenesis_Homo sapiens_hsa052030.92547234
48Legionellosis_Homo sapiens_hsa051340.90415666
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89006921
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88870960
51Apoptosis_Homo sapiens_hsa042100.87878817
52Influenza A_Homo sapiens_hsa051640.87245280
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87032034
54Shigellosis_Homo sapiens_hsa051310.86663641
55Toxoplasmosis_Homo sapiens_hsa051450.85993156
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85694551
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84955384
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80131026
59Rheumatoid arthritis_Homo sapiens_hsa053230.79325448
60African trypanosomiasis_Homo sapiens_hsa051430.77332668
61Prolactin signaling pathway_Homo sapiens_hsa049170.77147318
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.75972307
63N-Glycan biosynthesis_Homo sapiens_hsa005100.74375761
64mRNA surveillance pathway_Homo sapiens_hsa030150.74180355
65Basal transcription factors_Homo sapiens_hsa030220.70977863
66Chemokine signaling pathway_Homo sapiens_hsa040620.70444165
67Systemic lupus erythematosus_Homo sapiens_hsa053220.70359236
68Chronic myeloid leukemia_Homo sapiens_hsa052200.70064377
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68136564
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68045649
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67256769
72Colorectal cancer_Homo sapiens_hsa052100.67141432
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66881057
74Purine metabolism_Homo sapiens_hsa002300.66357606
75Pancreatic cancer_Homo sapiens_hsa052120.64532722
76FoxO signaling pathway_Homo sapiens_hsa040680.64515042
77Endocytosis_Homo sapiens_hsa041440.63849468
78Type I diabetes mellitus_Homo sapiens_hsa049400.63642229
79Regulation of autophagy_Homo sapiens_hsa041400.63523896
80Thyroid cancer_Homo sapiens_hsa052160.63391018
81Inositol phosphate metabolism_Homo sapiens_hsa005620.61666823
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61422172
83Platelet activation_Homo sapiens_hsa046110.60985536
84Small cell lung cancer_Homo sapiens_hsa052220.60237050
85MAPK signaling pathway_Homo sapiens_hsa040100.60161352
86Choline metabolism in cancer_Homo sapiens_hsa052310.57619896
87Sulfur relay system_Homo sapiens_hsa041220.57549543
88TNF signaling pathway_Homo sapiens_hsa046680.53309362
89Renal cell carcinoma_Homo sapiens_hsa052110.52789781
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50753246
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.49377818
92Tuberculosis_Homo sapiens_hsa051520.49038694
93Endometrial cancer_Homo sapiens_hsa052130.46378395
94Protein export_Homo sapiens_hsa030600.45404879
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.44884334
96Insulin resistance_Homo sapiens_hsa049310.44667639
97mTOR signaling pathway_Homo sapiens_hsa041500.44612914
98Other glycan degradation_Homo sapiens_hsa005110.44582386
99Non-small cell lung cancer_Homo sapiens_hsa052230.44076577
100Pertussis_Homo sapiens_hsa051330.43691580
101Hepatitis C_Homo sapiens_hsa051600.42800935
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.42477178
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.42399305
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.41185100
105Malaria_Homo sapiens_hsa051440.40110676
106Ras signaling pathway_Homo sapiens_hsa040140.39984601
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39274648
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38551496
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37419868
110Long-term potentiation_Homo sapiens_hsa047200.36108187
111Phagosome_Homo sapiens_hsa041450.34870631
112Dorso-ventral axis formation_Homo sapiens_hsa043200.34077782
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32613985
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32255719
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30830279
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30426378
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29160759
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.28708713
119Prostate cancer_Homo sapiens_hsa052150.27982410
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27564785
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.27226082
122Salmonella infection_Homo sapiens_hsa051320.26860369
123VEGF signaling pathway_Homo sapiens_hsa043700.26486776
124HIF-1 signaling pathway_Homo sapiens_hsa040660.26010675
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25646511
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24469378
127GnRH signaling pathway_Homo sapiens_hsa049120.23648578
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.23539106
129Notch signaling pathway_Homo sapiens_hsa043300.23288469
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22121988
131Linoleic acid metabolism_Homo sapiens_hsa005910.21745214
132Staphylococcus aureus infection_Homo sapiens_hsa051500.21717576
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21307023
134Type II diabetes mellitus_Homo sapiens_hsa049300.19933643
135ErbB signaling pathway_Homo sapiens_hsa040120.19550998

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