UBASH3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of dendrite morphogenesis (GO:0050774)6.56020240
2peripheral nervous system neuron development (GO:0048935)5.80513520
3neuronal action potential propagation (GO:0019227)5.20009598
4detection of temperature stimulus involved in sensory perception of pain (GO:0050965)5.16939893
5detection of temperature stimulus involved in sensory perception (GO:0050961)5.16939893
6neurofilament cytoskeleton organization (GO:0060052)4.94359804
7cell migration in hindbrain (GO:0021535)4.78701280
8detection of temperature stimulus (GO:0016048)4.70550157
9positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.52328907
10negative regulation of dendrite development (GO:2000171)4.47508008
11protein localization to endosome (GO:0036010)4.45449960
12negative regulation of calcium ion transport into cytosol (GO:0010523)4.38126736
13cell adhesion mediated by integrin (GO:0033627)4.34536991
14negative regulation of synaptic transmission, GABAergic (GO:0032229)4.20168101
15synaptic vesicle exocytosis (GO:0016079)4.02688621
16vocalization behavior (GO:0071625)4.01114079
17membrane raft organization (GO:0031579)3.98688461
18serotonin receptor signaling pathway (GO:0007210)3.87391148
19neuronal action potential (GO:0019228)3.79325192
20positive regulation of macrophage differentiation (GO:0045651)3.78785941
21hypotonic response (GO:0006971)3.67807034
22neutrophil activation involved in immune response (GO:0002283)3.60848292
23negative regulation of interleukin-12 production (GO:0032695)3.54499225
24neuron cell-cell adhesion (GO:0007158)3.53621416
25membrane depolarization during action potential (GO:0086010)3.51306548
26inositol phosphate catabolic process (GO:0071545)3.49752437
27synaptic vesicle maturation (GO:0016188)3.42807324
28response to peptidoglycan (GO:0032494)3.42670800
29regulation of NFAT protein import into nucleus (GO:0051532)3.41102627
30cellular extravasation (GO:0045123)3.34530702
31protein localization to synapse (GO:0035418)3.29793920
32regulation of synaptic vesicle exocytosis (GO:2000300)3.29694868
33innervation (GO:0060384)3.27145064
34positive regulation of leukocyte degranulation (GO:0043302)3.25559852
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.25225709
36barbed-end actin filament capping (GO:0051016)3.23746112
37glutamate secretion (GO:0014047)3.19300735
38gamma-aminobutyric acid transport (GO:0015812)3.18758691
39regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.18735006
40substrate-dependent cell migration (GO:0006929)3.18715746
41regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.16866719
42positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.15589881
43positive regulation of gamma-delta T cell activation (GO:0046645)3.15033037
44regulation of short-term neuronal synaptic plasticity (GO:0048172)3.12208923
45neurotransmitter secretion (GO:0007269)3.10873853
46response to acidic pH (GO:0010447)3.10367968
47regulation of macrophage cytokine production (GO:0010935)3.09823671
48proline transport (GO:0015824)3.07768766
49establishment of mitochondrion localization (GO:0051654)3.07465788
50regulation of synaptic vesicle transport (GO:1902803)3.04311953
51transferrin transport (GO:0033572)3.01820927
52cerebellar Purkinje cell differentiation (GO:0021702)3.00608437
53hepatocyte apoptotic process (GO:0097284)3.00185918
54regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.99948499
55mesodermal cell differentiation (GO:0048333)2.98144858
56calcium-mediated signaling using intracellular calcium source (GO:0035584)2.94737370
57skin morphogenesis (GO:0043589)2.94040209
58regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.92650840
59negative regulation of nitric oxide biosynthetic process (GO:0045019)2.92257420
60thrombin receptor signaling pathway (GO:0070493)2.91296706
61regulation of leukocyte degranulation (GO:0043300)2.90971688
62pinocytosis (GO:0006907)2.90101862
63hemidesmosome assembly (GO:0031581)2.90084557
64regulation of relaxation of muscle (GO:1901077)2.87115804
65sphingosine metabolic process (GO:0006670)2.82773006
66stress fiber assembly (GO:0043149)2.82354706
67negative regulation of interleukin-17 production (GO:0032700)2.82088132
68response to laminar fluid shear stress (GO:0034616)2.82026170
69phagosome maturation (GO:0090382)2.81440063
70behavioral response to pain (GO:0048266)2.80941876
71regulation of mast cell degranulation (GO:0043304)2.79725006
72granulocyte activation (GO:0036230)2.79703368
73lipopolysaccharide-mediated signaling pathway (GO:0031663)2.78625407
74regulation of synaptic transmission, GABAergic (GO:0032228)2.78036786
75trivalent inorganic cation transport (GO:0072512)2.74329750
76ferric iron transport (GO:0015682)2.74329750
77protein localization to microtubule (GO:0035372)2.73811586
78neuromuscular process controlling posture (GO:0050884)2.73239597
79detection of mechanical stimulus involved in sensory perception (GO:0050974)2.73208074
80response to pain (GO:0048265)2.70720639
81energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.70437095
82ATP hydrolysis coupled proton transport (GO:0015991)2.70437095
83germinal center formation (GO:0002467)2.68716837
84positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.68672580
85regulation of glutamate receptor signaling pathway (GO:1900449)2.68296320
86positive regulation of potassium ion transmembrane transport (GO:1901381)2.66571010
87positive regulation of amino acid transport (GO:0051957)2.66210873
88positive regulation of mast cell activation (GO:0033005)2.65756263
89glycosphingolipid catabolic process (GO:0046479)2.64984051
90regulation of mast cell activation involved in immune response (GO:0033006)2.64011265
91regulation of myeloid leukocyte mediated immunity (GO:0002886)2.63665798
92mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.63367367
93histamine secretion (GO:0001821)2.63176686
94establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.62024131
95mitochondrion transport along microtubule (GO:0047497)2.62024131
96positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.61240526
97positive regulation of mast cell activation involved in immune response (GO:0033008)2.60157994
98positive regulation of mast cell degranulation (GO:0043306)2.60157994
99positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.59312152
100synapse assembly (GO:0007416)2.57574058
101positive regulation of mitochondrial fission (GO:0090141)2.57270538
102regulation of mast cell activation (GO:0033003)2.57082516
103positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.56938842
104regulation of T-helper 2 cell differentiation (GO:0045628)2.56771197
105negative regulation of cation channel activity (GO:2001258)2.56706658
106negative regulation of monooxygenase activity (GO:0032769)2.55527746
107regulation of neuronal synaptic plasticity (GO:0048168)2.55365963
108negative regulation of microtubule polymerization (GO:0031115)2.54928203
109regulation of metalloenzyme activity (GO:0048552)2.54183724
110negative regulation of membrane potential (GO:0045837)2.53968980
111Arp2/3 complex-mediated actin nucleation (GO:0034314)2.53103661
112cortical actin cytoskeleton organization (GO:0030866)2.52992957
113regulation of neuron projection regeneration (GO:0070570)2.51804920
114regulation of axon regeneration (GO:0048679)2.51804920
115positive regulation of monocyte chemotaxis (GO:0090026)2.51365980
116neutrophil activation (GO:0042119)2.50959944
117positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.49405344
118negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.48378399
119membrane depolarization (GO:0051899)2.47594605
120response to muramyl dipeptide (GO:0032495)2.47093234
121angiogenesis involved in wound healing (GO:0060055)2.47081420
122exploration behavior (GO:0035640)2.46448325
123regulation of T-helper 1 cell differentiation (GO:0045625)2.45676655
124integrin-mediated signaling pathway (GO:0007229)2.45282399
125organelle transport along microtubule (GO:0072384)2.45010081
126apoptotic cell clearance (GO:0043277)2.44950405
127cellular response to vitamin D (GO:0071305)2.44108315
128leukocyte degranulation (GO:0043299)2.43121981
129action potential (GO:0001508)2.43113505
130B cell receptor signaling pathway (GO:0050853)2.41580509
131detection of molecule of bacterial origin (GO:0032490)2.41580092
132regulation of glutamate secretion (GO:0014048)2.41533739
133regulation of B cell receptor signaling pathway (GO:0050855)2.40032159
134cellular response to ethanol (GO:0071361)2.39536052
135neurotransmitter transport (GO:0006836)2.39087764
136positive regulation of synaptic transmission, GABAergic (GO:0032230)2.38595963
137oligosaccharide catabolic process (GO:0009313)2.38252635
138positive regulation of cardiac muscle hypertrophy (GO:0010613)2.37357649
139positive regulation of muscle hypertrophy (GO:0014742)2.37357649
140positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.36795760
141regulation of glycogen (starch) synthase activity (GO:2000465)2.36700260
142neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.36626025
143regulation of cell communication by electrical coupling (GO:0010649)2.36167414
144phagocytosis, engulfment (GO:0006911)2.35120714
145myeloid cell activation involved in immune response (GO:0002275)2.34458732
146negative regulation of thymocyte apoptotic process (GO:0070244)2.34111216
147cellular copper ion homeostasis (GO:0006878)2.33297661
148regulation of amyloid precursor protein catabolic process (GO:1902991)2.33211212
149gamma-aminobutyric acid signaling pathway (GO:0007214)2.33171290
150macrophage activation involved in immune response (GO:0002281)2.32720802
151regulation of fever generation (GO:0031620)2.32294407
152vesicle transport along microtubule (GO:0047496)2.32070230
153response to progesterone (GO:0032570)2.31299541
154diol metabolic process (GO:0034311)2.30817472
155negative regulation of nitric-oxide synthase activity (GO:0051001)2.30748847
156regulation of superoxide anion generation (GO:0032928)2.30667923
157negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.30150962
158clathrin coat assembly (GO:0048268)2.30091052
159negative regulation of heart rate (GO:0010459)2.29878730
160regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.29805741
161cell-substrate junction assembly (GO:0007044)2.29529968
162negative regulation of smooth muscle contraction (GO:0045986)2.29308103
163negative regulation of cell killing (GO:0031342)2.29194180
164negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.29194180
165negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.29173892
166regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.29163063
167negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.28876724
168negative regulation of T-helper cell differentiation (GO:0045623)2.28876724
169positive regulation of B cell differentiation (GO:0045579)2.28658886
170decidualization (GO:0046697)2.28100274
171cellular response to thyroid hormone stimulus (GO:0097067)2.27928700
172negative regulation of mast cell activation (GO:0033004)2.27810247
173positive regulation of regulated secretory pathway (GO:1903307)2.27747684
174establishment of endothelial barrier (GO:0061028)2.27132034
175synaptic vesicle transport (GO:0048489)2.27107156
176establishment of synaptic vesicle localization (GO:0097480)2.27107156
177glycolipid catabolic process (GO:0019377)2.27046391
178amino sugar catabolic process (GO:0046348)2.26999043
179regulation of vitamin D biosynthetic process (GO:0060556)2.26587224
180regulation of synaptic transmission, glutamatergic (GO:0051966)2.26571589
181positive regulation by symbiont of host defense response (GO:0052509)2.26320140
182modulation by symbiont of host defense response (GO:0052031)2.26320140
183modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.26320140
184modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.26320140
185positive regulation by organism of defense response of other organism involved in symbiotic interact2.26320140
186modulation by symbiont of host immune response (GO:0052553)2.26320140
187ionotropic glutamate receptor signaling pathway (GO:0035235)2.26167337
188negative regulation of anoikis (GO:2000811)2.25487518
189inositol phosphate dephosphorylation (GO:0046855)2.24521839
190phosphorylated carbohydrate dephosphorylation (GO:0046838)2.24521839
191regulation of protein heterodimerization activity (GO:0043497)2.24407341
192membrane repolarization (GO:0086009)2.24154104
193positive regulation of heat generation (GO:0031652)2.23558767
194regulation of sodium ion transmembrane transporter activity (GO:2000649)2.23042068
195endodermal cell differentiation (GO:0035987)2.22750972
196regulation of cell adhesion mediated by integrin (GO:0033628)2.22181949
197negative regulation of cytokine production involved in immune response (GO:0002719)2.22111129
198leukocyte aggregation (GO:0070486)2.21570067
199membrane protein ectodomain proteolysis (GO:0006509)2.21071823
200sprouting angiogenesis (GO:0002040)2.20133752

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.91831461
2GBX2_23144817_ChIP-Seq_PC3_Human3.90112439
3MYB_21317192_ChIP-Seq_ERMYB_Mouse3.65409266
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.35985785
5TAF15_26573619_Chip-Seq_HEK293_Human3.30995605
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.96510665
7* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.95378917
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.71100491
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68858796
10IGF1R_20145208_ChIP-Seq_DFB_Human2.68216888
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.64813145
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.59653082
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.59281187
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.54777628
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48824070
16GATA2_21666600_ChIP-Seq_HMVEC_Human2.42849675
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.27423835
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.23786171
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22839099
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.20058373
21SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.19264681
22SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.19264681
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17771654
24REST_21632747_ChIP-Seq_MESCs_Mouse2.16151662
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.15816762
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.10880054
27BP1_19119308_ChIP-ChIP_Hs578T_Human2.09960816
28SCL_19346495_ChIP-Seq_HPC-7_Human2.09677127
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.08616393
30JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08068823
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.07991483
32STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00091250
33RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00030993
34EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00030993
35* VDR_24787735_ChIP-Seq_THP-1_Human1.99729175
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.99392967
37SMAD4_21799915_ChIP-Seq_A2780_Human1.99163461
38P300_19829295_ChIP-Seq_ESCs_Human1.98131965
39* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95103008
40* VDR_24763502_ChIP-Seq_THP-1_Human1.94728010
41SPI1_23127762_ChIP-Seq_K562_Human1.92031054
42NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.91762706
43* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.89995176
44* BRD4_25478319_ChIP-Seq_HGPS_Human1.89022971
45AR_21572438_ChIP-Seq_LNCaP_Human1.88438072
46SPI1_23547873_ChIP-Seq_NB4_Human1.83565333
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82668938
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.82106925
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80496400
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.76236355
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74525227
52MYB_26560356_Chip-Seq_TH2_Human1.72495494
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72216392
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.71898280
55* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71166871
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.70502908
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70204603
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.68817963
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.68274993
60* ELK3_25401928_ChIP-Seq_HUVEC_Human1.68102920
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.63066888
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62076098
63JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60785902
64PPAR_26484153_Chip-Seq_NCI-H1993_Human1.60480253
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.60174041
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58753392
67JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58653341
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58099286
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55452670
70* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55330053
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51675257
72* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51022001
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50083134
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49849949
75* AR_25329375_ChIP-Seq_VCAP_Human1.49702051
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49363737
77RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48814422
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.48655003
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48529716
80CJUN_26792858_Chip-Seq_BT549_Human1.47569592
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46052206
82RNF2_27304074_Chip-Seq_NSC_Mouse1.46041323
83* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45348273
84GATA1_22025678_ChIP-Seq_K562_Human1.45192789
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.44967955
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43654539
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.41685189
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.40920940
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40688777
90PU_27001747_Chip-Seq_BMDM_Mouse1.40683370
91VDR_21846776_ChIP-Seq_THP-1_Human1.40620091
92MYB_26560356_Chip-Seq_TH1_Human1.39486336
93RUNX_20019798_ChIP-Seq_JUKART_Human1.39125345
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38597032
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37914597
96EED_16625203_ChIP-ChIP_MESCs_Mouse1.36391104
97SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36366984
98* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35783424
99RARB_27405468_Chip-Seq_BRAIN_Mouse1.35086159
100* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34163126
101MYC_22102868_ChIP-Seq_BL_Human1.33457193
102* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33191085
103STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29927610
104PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28411448
105MAF_26560356_Chip-Seq_TH1_Human1.27163463
106* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26647564
107* STAT3_23295773_ChIP-Seq_U87_Human1.26446795
108KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25808512
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.25306358
110AHR_22903824_ChIP-Seq_MCF-7_Human1.25050128
111* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24810689
112CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24423825
113* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.24377896
114CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24328549
115SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23716204
116JUN_21703547_ChIP-Seq_K562_Human1.22515986
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22066121
118* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.21524278
119AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21334352
120TCF7_22412390_ChIP-Seq_EML_Mouse1.21124425
121SOX2_21211035_ChIP-Seq_LN229_Gbm1.20447339
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19556688
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18550710
124ARNT_22903824_ChIP-Seq_MCF-7_Human1.18139683
125* GATA1_19941827_ChIP-Seq_MEL_Mouse1.17803681
126LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16876755
127CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16860626
128KDM2B_26808549_Chip-Seq_REH_Human1.16696813
129PIAS1_25552417_ChIP-Seq_VCAP_Human1.16047206
130TFEB_21752829_ChIP-Seq_HELA_Human1.15770051
131SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14978265
132SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14465433
133KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14030475
134* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12285149
135NANOG_18555785_Chip-Seq_ESCs_Mouse1.10965756
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10770191
137ER_23166858_ChIP-Seq_MCF-7_Human1.10647037
138CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10162542
139GATA1_19941826_ChIP-Seq_K562_Human1.09872082
140IRF8_27001747_Chip-Seq_BMDM_Mouse1.08475179
141ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08395838
142* UBF1/2_26484160_Chip-Seq_HMECs_Human1.07772351
143PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07672913
144TP53_16413492_ChIP-PET_HCT116_Human1.07097456
145TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07037672
146LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06831332
147MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06419601
148* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06354071
149TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06041364
150CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04637958
151KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04489572
152P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03962983
153DROSHA_22980978_ChIP-Seq_HELA_Human1.03558304
154RUNX2_22187159_ChIP-Seq_PCA_Human1.03526749
155MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03053935
156E2F1_18555785_Chip-Seq_ESCs_Mouse1.02916149
157TCF4_23295773_ChIP-Seq_U87_Human1.02858869
158WT1_19549856_ChIP-ChIP_CCG9911_Human1.01819616
159NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01550887
160NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01550887
161UTX_26944678_Chip-Seq_JUKART_Human1.01408786
162ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01392809
163GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00556983
164SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00429508
165GATA3_27048872_Chip-Seq_THYMUS_Human0.99668809
166P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99178320
167SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99155646
168FLI1_27457419_Chip-Seq_LIVER_Mouse0.98979162
169CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97313999
170IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97211430
171STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96383512
172E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96253801
173* FOXO3_23340844_ChIP-Seq_DLD1_Human0.96028768
174SOX2_19829295_ChIP-Seq_ESCs_Human0.95126370
175NANOG_19829295_ChIP-Seq_ESCs_Human0.95126370
176ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94627575
177GATA2_19941826_ChIP-Seq_K562_Human0.93962090
178IRF8_22096565_ChIP-ChIP_GC-B_Human0.93842806
179CMYC_18555785_Chip-Seq_ESCs_Mouse0.93388741
180TCF4_22108803_ChIP-Seq_LS180_Human0.93079348
181GATA3_26560356_Chip-Seq_TH2_Human0.93061755
182P53_22387025_ChIP-Seq_ESCs_Mouse0.92453634
183SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92346714
184BCAT_22108803_ChIP-Seq_LS180_Human0.91837936
185CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90642042

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception5.96103029
2MP0001986_abnormal_taste_sensitivity4.73581781
3MP0004270_analgesia3.92093671
4MP0001968_abnormal_touch/_nociception3.83056203
5MP0002736_abnormal_nociception_after3.70885198
6MP0009046_muscle_twitch3.38683824
7MP0002877_abnormal_melanocyte_morpholog3.19512018
8MP0006276_abnormal_autonomic_nervous3.15829933
9MP0004859_abnormal_synaptic_plasticity3.13517743
10MP0003191_abnormal_cellular_cholesterol3.13337086
11MP0002734_abnormal_mechanical_nocicepti3.08639352
12MP0004858_abnormal_nervous_system2.90854321
13MP0002733_abnormal_thermal_nociception2.76368460
14MP0003566_abnormal_cell_adhesion2.64139659
15MP0003300_gastrointestinal_ulcer2.62561690
16MP0003635_abnormal_synaptic_transmissio2.61525091
17MP0001970_abnormal_pain_threshold2.56830368
18MP0003880_abnormal_central_pattern2.55264361
19MP0006054_spinal_hemorrhage2.46719061
20MP0002064_seizures2.40628029
21MP0009745_abnormal_behavioral_response2.36231505
22MP0002272_abnormal_nervous_system2.35947974
23MP0004147_increased_porphyrin_level2.25142709
24MP0003950_abnormal_plasma_membrane2.23719007
25MP0003091_abnormal_cell_migration2.16111845
26MP0002067_abnormal_sensory_capabilities2.13111764
27MP0004947_skin_inflammation2.11779528
28MP0002184_abnormal_innervation2.08738829
29MP0002063_abnormal_learning/memory/cond2.06816673
30MP0008438_abnormal_cutaneous_collagen1.96206447
31MP0003705_abnormal_hypodermis_morpholog1.92395945
32MP0002572_abnormal_emotion/affect_behav1.91646865
33MP0001853_heart_inflammation1.88452366
34MP0000685_abnormal_immune_system1.84866034
35MP0000858_altered_metastatic_potential1.79984457
36MP0003724_increased_susceptibility_to1.79860252
37MP0005023_abnormal_wound_healing1.79127554
38MP0003828_pulmonary_edema1.79056874
39MP0009840_abnormal_foam_cell1.76439118
40MP0000343_altered_response_to1.75770096
41MP0003279_aneurysm1.74201886
42MP0001188_hyperpigmentation1.73413965
43MP0002998_abnormal_bone_remodeling1.72072439
44MP0010352_gastrointestinal_tract_polyps1.71232447
45MP0001501_abnormal_sleep_pattern1.70191824
46MP0008569_lethality_at_weaning1.68505737
47MP0003448_altered_tumor_morphology1.64694462
48MP0002396_abnormal_hematopoietic_system1.63017407
49MP0009278_abnormal_bone_marrow1.61913696
50MP0004510_myositis1.60311173
51MP0005451_abnormal_body_composition1.56808079
52MP0003763_abnormal_thymus_physiology1.55105386
53MP0001486_abnormal_startle_reflex1.52634878
54MP0004811_abnormal_neuron_physiology1.51724302
55MP0002405_respiratory_system_inflammati1.51640092
56MP0004808_abnormal_hematopoietic_stem1.48586251
57MP0005164_abnormal_response_to1.48062327
58MP0004142_abnormal_muscle_tone1.47886386
59MP0003183_abnormal_peptide_metabolism1.46740775
60MP0001533_abnormal_skeleton_physiology1.46334404
61MP0002822_catalepsy1.45049700
62MP0003787_abnormal_imprinting1.41960298
63MP0001835_abnormal_antigen_presentation1.38012034
64MP0001348_abnormal_lacrimal_gland1.36665621
65MP0000015_abnormal_ear_pigmentation1.35904733
66MP0005671_abnormal_response_to1.33057417
67MP0003453_abnormal_keratinocyte_physiol1.30103897
68MP0005397_hematopoietic_system_phenotyp1.29478786
69MP0001545_abnormal_hematopoietic_system1.29478786
70MP0005423_abnormal_somatic_nervous1.29450078
71MP0005257_abnormal_intraocular_pressure1.29326022
72MP0001958_emphysema1.28192543
73MP0004924_abnormal_behavior1.27334416
74MP0005386_behavior/neurological_phenoty1.27334416
75MP0008260_abnormal_autophagy1.25923147
76MP0003075_altered_response_to1.25461905
77MP0000955_abnormal_spinal_cord1.25354642
78MP0003303_peritoneal_inflammation1.25325131
79MP0000372_irregular_coat_pigmentation1.24708592
80MP0002398_abnormal_bone_marrow1.24159128
81MP0001984_abnormal_olfaction1.23771558
82MP0005623_abnormal_meninges_morphology1.22024204
83MP0005165_increased_susceptibility_to1.19495691
84MP0000716_abnormal_immune_system1.18765104
85MP0001440_abnormal_grooming_behavior1.18445837
86MP0002557_abnormal_social/conspecific_i1.17787040
87MP0002751_abnormal_autonomic_nervous1.17762777
88MP0001849_ear_inflammation1.17745022
89MP0004883_abnormal_blood_vessel1.16653967
90MP0009764_decreased_sensitivity_to1.15305482
91MP0006082_CNS_inflammation1.14787288
92MP0004272_abnormal_basement_membrane1.14510104
93MP0002148_abnormal_hypersensitivity_rea1.13822271
94MP0000604_amyloidosis1.11580680
95MP0003879_abnormal_hair_cell1.11402810
96MP0003329_amyloid_beta_deposits1.11081735
97MP0000778_abnormal_nervous_system1.09608707
98MP0001845_abnormal_inflammatory_respons1.09374693
99MP0001905_abnormal_dopamine_level1.09371381
100MP0003656_abnormal_erythrocyte_physiolo1.09199971
101MP0002722_abnormal_immune_system1.08964384
102MP0010155_abnormal_intestine_physiology1.08320996
103MP0002882_abnormal_neuron_morphology1.07494175
104MP0002006_tumorigenesis1.07148620
105MP0003045_fibrosis1.06688309
106MP0002066_abnormal_motor_capabilities/c1.06041643
107MP0000465_gastrointestinal_hemorrhage1.03112865
108MP0001851_eye_inflammation1.02962989
109MP0000689_abnormal_spleen_morphology1.02786262
110MP0005171_absent_coat_pigmentation1.02346385
111MP0009333_abnormal_splenocyte_physiolog1.01366443
112MP0001915_intracranial_hemorrhage1.00343407
113MP0005000_abnormal_immune_tolerance1.00124894
114MP0004742_abnormal_vestibular_system0.99814988
115MP0002429_abnormal_blood_cell0.99513165
116MP0000767_abnormal_smooth_muscle0.99331066
117MP0001542_abnormal_bone_strength0.98849915
118MP0002166_altered_tumor_susceptibility0.96995417
119MP0000569_abnormal_digit_pigmentation0.96893039
120MP0002060_abnormal_skin_morphology0.94661709
121MP0003172_abnormal_lysosome_physiology0.94332130
122MP0002229_neurodegeneration0.93867049
123MP0001243_abnormal_dermal_layer0.93748117
124MP0002419_abnormal_innate_immunity0.92042869
125MP0001963_abnormal_hearing_physiology0.91643321
126MP0008469_abnormal_protein_level0.90246636
127MP0000920_abnormal_myelination0.89573356
128MP0001529_abnormal_vocalization0.88619177
129MP0000249_abnormal_blood_vessel0.87696950
130MP0005464_abnormal_platelet_physiology0.85825569
131MP0003122_maternal_imprinting0.85546269
132MP0005646_abnormal_pituitary_gland0.85399333
133MP0004185_abnormal_adipocyte_glucose0.83989516
134MP0003795_abnormal_bone_structure0.83537658
135MP0005621_abnormal_cell_physiology0.83513202
136MP0003633_abnormal_nervous_system0.83300955
137MP0000703_abnormal_thymus_morphology0.83074251
138MP0001216_abnormal_epidermal_layer0.82143456
139MP0005166_decreased_susceptibility_to0.80663778
140MP0003634_abnormal_glial_cell0.79894787
141MP0009763_increased_sensitivity_to0.78015040
142MP0008004_abnormal_stomach_pH0.77733321
143MP0010386_abnormal_urinary_bladder0.77696526
144MP0003631_nervous_system_phenotype0.77498846
145MP0003646_muscle_fatigue0.76885577
146MP0005058_abnormal_lysosome_morphology0.76581115
147MP0002876_abnormal_thyroid_physiology0.75597709
148MP0001191_abnormal_skin_condition0.74903805
149MP0002723_abnormal_immune_serum0.74875218
150MP0009785_altered_susceptibility_to0.74777934
151MP0000733_abnormal_muscle_development0.73955600
152MP0003436_decreased_susceptibility_to0.73896444
153MP0005310_abnormal_salivary_gland0.73320949
154MP0001819_abnormal_immune_cell0.72868873
155MP0002420_abnormal_adaptive_immunity0.72489452
156MP0002452_abnormal_antigen_presenting0.71711512
157MP0002332_abnormal_exercise_endurance0.69596570
158MP0005387_immune_system_phenotype0.69445169
159MP0001790_abnormal_immune_system0.69445169
160MP0001800_abnormal_humoral_immune0.69078785
161MP0003866_abnormal_defecation0.68879701
162MP0002752_abnormal_somatic_nervous0.66494423
163MP0005174_abnormal_tail_pigmentation0.64884643
164MP0001502_abnormal_circadian_rhythm0.64681185
165MP0005645_abnormal_hypothalamus_physiol0.64617949
166MP0009697_abnormal_copulation0.62632259
167MP0008874_decreased_physiological_sensi0.61765246
168MP0005025_abnormal_response_to0.60442785
169MP0001270_distended_abdomen0.59182066
170MP0004484_altered_response_of0.55417285
171MP0004085_abnormal_heartbeat0.53590206
172MP0005535_abnormal_body_temperature0.53280685

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.59410937
2Febrile seizures (HP:0002373)5.94285044
3Atonic seizures (HP:0010819)5.93323801
4Myokymia (HP:0002411)5.61627150
5Ulnar claw (HP:0001178)4.97808784
6Action tremor (HP:0002345)4.64585859
7Hypothermia (HP:0002045)4.41258301
8Abnormality of glycolipid metabolism (HP:0010969)4.36264094
9Abnormality of liposaccharide metabolism (HP:0010968)4.36264094
10Focal seizures (HP:0007359)4.35570531
11Neuroendocrine neoplasm (HP:0100634)4.05028854
12Abnormal hair whorl (HP:0010721)4.01616114
13Progressive cerebellar ataxia (HP:0002073)3.92251561
14Pheochromocytoma (HP:0002666)3.89054446
15Absence seizures (HP:0002121)3.78577975
16Epileptic encephalopathy (HP:0200134)3.73072412
17Dialeptic seizures (HP:0011146)3.57581153
18Progressive inability to walk (HP:0002505)3.54849876
19T lymphocytopenia (HP:0005403)3.54338917
20Myocardial infarction (HP:0001658)3.34442630
21Abnormality of macrophages (HP:0004311)3.27775314
22Spondylolisthesis (HP:0003302)3.21594059
23Failure to thrive in infancy (HP:0001531)3.18691057
24Termporal pattern (HP:0011008)3.18271039
25Insidious onset (HP:0003587)3.18271039
26Abnormality of T cell number (HP:0011839)3.08984769
27Generalized tonic-clonic seizures (HP:0002069)3.02451447
28Eczematoid dermatitis (HP:0000976)2.97029151
29Neurofibrillary tangles (HP:0002185)2.95582432
30B lymphocytopenia (HP:0010976)2.94172963
31Abnormal platelet volume (HP:0011876)2.88252375
32Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.86492053
33Vacuolated lymphocytes (HP:0001922)2.84756005
34Increased mean platelet volume (HP:0011877)2.84300397
35Dysostosis multiplex (HP:0000943)2.76963575
36Upper motor neuron abnormality (HP:0002127)2.76693452
37Osteolytic defects of the phalanges of the hand (HP:0009771)2.75360410
38Osteolytic defects of the hand bones (HP:0009699)2.75360410
39Arterial tortuosity (HP:0005116)2.75077688
40Abnormality of pain sensation (HP:0010832)2.72162791
41Impaired pain sensation (HP:0007328)2.72162791
42Premature rupture of membranes (HP:0001788)2.71781812
43Visual hallucinations (HP:0002367)2.70492304
44Cerebral inclusion bodies (HP:0100314)2.70149294
45Recurrent viral infections (HP:0004429)2.68035711
46Abnormality of B cell number (HP:0010975)2.65409083
47Truncal ataxia (HP:0002078)2.65184791
48Segmental peripheral demyelination/remyelination (HP:0003481)2.61065357
49Gaze-evoked nystagmus (HP:0000640)2.61062412
50Panhypogammaglobulinemia (HP:0003139)2.60945343
51Neoplasm of the peripheral nervous system (HP:0100007)2.59524485
52Petechiae (HP:0000967)2.57095406
53Vascular tortuosity (HP:0004948)2.56712486
54Fetal akinesia sequence (HP:0001989)2.54902834
55Abnormality of binocular vision (HP:0011514)2.52020388
56Diplopia (HP:0000651)2.52020388
57Supranuclear gaze palsy (HP:0000605)2.51058121
58Recurrent abscess formation (HP:0002722)2.48268860
59Recurrent fungal infections (HP:0002841)2.47708999
60Impaired platelet aggregation (HP:0003540)2.45580723
61Abnormal platelet function (HP:0011869)2.45580723
62Poor suck (HP:0002033)2.45472826
63Submucous cleft hard palate (HP:0000176)2.42594237
64Limb dystonia (HP:0002451)2.40710723
65Prolonged bleeding time (HP:0003010)2.40252344
66Eosinophilia (HP:0001880)2.37021323
67Mutism (HP:0002300)2.36464013
68Autoamputation (HP:0001218)2.36461680
69Atrophic scars (HP:0001075)2.36164345
70Cellulitis (HP:0100658)2.34812042
71Epistaxis (HP:0000421)2.34243698
72Subacute progressive viral hepatitis (HP:0006572)2.33917703
73Hypoplasia of the thymus (HP:0000778)2.29992416
74Granulocytopenia (HP:0001913)2.29320471
75Thick nail (HP:0001805)2.29176329
76Scanning speech (HP:0002168)2.28340276
77Abnormal eating behavior (HP:0100738)2.28088294
78Bradycardia (HP:0001662)2.27938474
79Bilateral sensorineural hearing impairment (HP:0008619)2.27801843
80Elevated erythrocyte sedimentation rate (HP:0003565)2.27325410
81Disinhibition (HP:0000734)2.25932455
82Spontaneous hematomas (HP:0007420)2.22990902
83Axonal loss (HP:0003447)2.21281843
84Stomatitis (HP:0010280)2.19895734
85Abnormality of polysaccharide metabolism (HP:0011012)2.19424079
86Abnormality of glycosaminoglycan metabolism (HP:0004371)2.19424079
87Abnormality of mucopolysaccharide metabolism (HP:0011020)2.19424079
88Aortic dissection (HP:0002647)2.19028763
89Inability to walk (HP:0002540)2.17476350
90Autoimmune thrombocytopenia (HP:0001973)2.17065070
91Polyphagia (HP:0002591)2.16520838
92Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.15851420
93Hepatosplenomegaly (HP:0001433)2.14610071
94Mucopolysacchariduria (HP:0008155)2.14232716
95Urinary glycosaminoglycan excretion (HP:0003541)2.14232716
96Loss of speech (HP:0002371)2.14207943
97Viral hepatitis (HP:0006562)2.14144744
98Combined immunodeficiency (HP:0005387)2.13233249
99Steppage gait (HP:0003376)2.12056274
100Abnormality of the vocal cords (HP:0008777)2.11294787
101Recurrent bacterial skin infections (HP:0005406)2.09997395
102Foot dorsiflexor weakness (HP:0009027)2.09196326
103Akinesia (HP:0002304)2.07687399
104Urinary bladder sphincter dysfunction (HP:0002839)2.06396382
105Pustule (HP:0200039)2.05974918
106Spastic gait (HP:0002064)2.04984894
107Ankle clonus (HP:0011448)2.04766523
108Hypoplasia of the brainstem (HP:0002365)2.03929197
109Aplasia/Hypoplasia of the brainstem (HP:0007362)2.03929197
110Aortic aneurysm (HP:0004942)2.03890596
111Urinary urgency (HP:0000012)2.03405314
112Thyroid carcinoma (HP:0002890)2.02175434
113Menorrhagia (HP:0000132)2.01739017
114Glomerulopathy (HP:0100820)2.00064854
115Interstitial pulmonary disease (HP:0006530)1.99174619
116Generalized hypotonia (HP:0001290)1.98280838
117Lower limb asymmetry (HP:0100559)1.97844450
118Leukocytosis (HP:0001974)1.97143556
119Distal lower limb amyotrophy (HP:0008944)1.96769624
120Fatigue (HP:0012378)1.96103519
121Protrusio acetabuli (HP:0003179)1.95613038
122Purpura (HP:0000979)1.94766083
123Abnormality of T cells (HP:0002843)1.93778217
124Abnormality of oral frenula (HP:0000190)1.93121118
125Abnormality of the corticospinal tract (HP:0002492)1.92880797
126Meningitis (HP:0001287)1.92416139
127Dysautonomia (HP:0002459)1.91992811
128Dilatation of the ascending aorta (HP:0005111)1.91838503
129Myositis (HP:0100614)1.91426305
130Increased neuronal autofluorescent lipopigment (HP:0002074)1.91322111
131Vertebral compression fractures (HP:0002953)1.90542300
132Increased cerebral lipofuscin (HP:0011813)1.89830530
133Spinal canal stenosis (HP:0003416)1.88621910
134Mitral stenosis (HP:0001718)1.86917244
135Tetraparesis (HP:0002273)1.86466704
136Recurrent skin infections (HP:0001581)1.84337910
137Impaired vibration sensation in the lower limbs (HP:0002166)1.83297808
138Orchitis (HP:0100796)1.83268983
139Severe combined immunodeficiency (HP:0004430)1.82926936
140Apathy (HP:0000741)1.82839469
141Abnormality of the foot musculature (HP:0001436)1.82394754
142Hammertoe (HP:0001765)1.81638699
143Spinal cord lesions (HP:0100561)1.81078047
144Syringomyelia (HP:0003396)1.81078047
145Oligomenorrhea (HP:0000876)1.80114412
146Osteomyelitis (HP:0002754)1.79229825
147Chronic mucocutaneous candidiasis (HP:0002728)1.79206410
148Recurrent cutaneous fungal infections (HP:0011370)1.79206410
149Broad face (HP:0000283)1.79066704
150Delayed gross motor development (HP:0002194)1.78882202
151Wormian bones (HP:0002645)1.78188621
152Narrow nasal bridge (HP:0000446)1.77806870
153Global brain atrophy (HP:0002283)1.76782062
154Hyperventilation (HP:0002883)1.76667383
155Abnormality of the vasculature of the conjunctiva (HP:0008054)1.76067848
156Chronic obstructive pulmonary disease (HP:0006510)1.75885416
157Obstructive lung disease (HP:0006536)1.75885416
158Milia (HP:0001056)1.75161862
159Depression (HP:0000716)1.74873308
160Esotropia (HP:0000565)1.74842225
161Psychosis (HP:0000709)1.73882956
162Abnormality of eosinophils (HP:0001879)1.73575111
163Optic neuritis (HP:0100653)1.73565593
164Retrobulbar optic neuritis (HP:0100654)1.73565593
165Amyloidosis (HP:0011034)1.73476810
166Cerebral hemorrhage (HP:0001342)1.73140604
167Gingival bleeding (HP:0000225)1.71723747
168Absent frontal sinuses (HP:0002688)1.70074575
169Neuronal loss in central nervous system (HP:0002529)1.69963465
170Pulmonary infiltrates (HP:0002113)1.69329735
171Mediastinal lymphadenopathy (HP:0100721)1.69311619
172Decreased motor nerve conduction velocity (HP:0003431)1.68945951
173Hypercortisolism (HP:0001578)1.67884875
174Slow saccadic eye movements (HP:0000514)1.67652322
175Decreased muscle mass (HP:0003199)1.67293096
176Distal sensory impairment (HP:0002936)1.65782018
177Aqueductal stenosis (HP:0002410)1.65190526
178Anxiety (HP:0000739)1.65181869
179Acute necrotizing encephalopathy (HP:0006965)1.64427668
180Dysmetria (HP:0001310)1.63686161
181Amblyopia (HP:0000646)1.63059412
182Diminished motivation (HP:0000745)1.62914382
183Postural tremor (HP:0002174)1.62077243
184Specific learning disability (HP:0001328)1.60528881
185Agitation (HP:0000713)1.59513873
186Heterochromia iridis (HP:0001100)1.59097742
187Absent speech (HP:0001344)1.58956580
188Abnormality of glycosphingolipid metabolism (HP:0004343)1.58612287

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.86878724
2IRAK33.81403577
3MAP3K123.69354184
4SIK33.65897158
5MINK13.32831631
6NTRK33.26475988
7MAP2K72.82813884
8TGFBR22.70558435
9MAP3K32.35806258
10MAP3K42.19652967
11SGK22.07822867
12LATS21.95765254
13STK101.92028524
14MST1R1.87601807
15MAP3K91.86739555
16RIPK41.85365819
17MAP2K31.84711526
18CAMKK21.82825639
19TTN1.81796745
20NTRK11.77706984
21MAP3K141.77248668
22NEK91.74580146
23PAK41.72057264
24PRPF4B1.65426839
25MAP2K41.63428717
26PDGFRA1.61845982
27EPHB11.59431070
28GRK51.58545002
29GRK71.58399257
30ARAF1.56273739
31MATK1.55930709
32MET1.54985820
33SGK2231.54755189
34SGK4941.54755189
35MAPK131.54181614
36LATS11.49990017
37MARK11.49039983
38TXK1.48186095
39BLK1.47664915
40STK241.44353761
41EPHA21.44009558
42SGK31.43849161
43NME21.43027516
44CSK1.40022561
45LIMK11.35673568
46PLK21.35206071
47YES11.34047051
48ERN11.29154538
49STK381.28367706
50KIT1.27496604
51ERBB41.26956594
52TESK11.26232965
53TESK21.25692382
54RPS6KA21.25151895
55BTK1.23568220
56CSF1R1.22491543
57CDK61.20797577
58FES1.18865805
59TAOK21.15518419
60BMPR21.11951227
61TRIM281.11243553
62TNK21.08910128
63PTK21.08179102
64TRPM71.07438983
65PTK2B1.05360838
66CAMK1D1.03684901
67MYLK1.03675823
68BCR1.01368126
69ADRBK20.98530323
70HCK0.98352931
71BMPR1B0.98004832
72KSR20.97972308
73CAMKK10.95761218
74SCYL20.94687359
75FLT30.94601758
76PIK3CG0.92396046
77NTRK20.91589773
78CLK10.90413439
79CDK80.89920645
80PRKCH0.88431432
81PAK20.88145712
82LMTK20.87572728
83PIM20.87480878
84SYK0.87437735
85TSSK60.86939008
86TYK20.86265139
87PRKCG0.86167055
88PDGFRB0.85182759
89FGR0.82204738
90CDK50.81628285
91ABL20.78700781
92WNK10.78653068
93AKT30.77643872
94BMX0.74603580
95ZAP700.73787658
96PRKCE0.73617808
97MAPKAPK30.73160722
98SIK20.71699670
99RET0.70030031
100CDC42BPA0.66287842
101IKBKB0.65762242
102MAP2K10.65715015
103EPHA30.65141549
104SMG10.64311064
105CAMK1G0.63409764
106HIPK20.61434089
107MAPKAPK20.61235145
108MELK0.60547073
109MAP3K80.60414440
110MAP3K130.58821482
111TBK10.58588067
112KSR10.58293199
113GRK60.56743251
114ICK0.54947675
115DAPK10.54794483
116ADRBK10.54264760
117MAP4K10.53476786
118IRAK20.53307112
119CAMK2A0.52256507
120MARK30.51583821
121MAP3K60.51574295
122LCK0.50771531
123RPS6KL10.50594794
124RPS6KC10.50594794
125BRAF0.50369589
126TNIK0.50312397
127LYN0.48883310
128GSK3A0.47788789
129DDR20.47702566
130MAP3K20.46435268
131IRAK10.45516005
132RPS6KA60.45281389
133DYRK20.45258651
134MAP3K10.45108694
135RPS6KB10.44948902
136ABL10.44341975
137MAPK110.44291466
138FGFR30.43888715
139PAK60.43737846
140MST40.42801461
141MAPKAPK50.41568790
142PRKG20.41277285
143PHKG20.40946737
144PHKG10.40946737
145MUSK0.40558030
146ITK0.38929517
147CAMK2G0.38511293
148STK30.38392262
149BRSK10.37494208
150CCNB10.37149851
151PDK10.36596128
152IKBKE0.36486415
153JAK10.36471139
154CDK140.34195783
155IRAK40.33587682
156ROCK20.31945643
157DAPK20.31893543
158CDK180.31882762
159TEC0.31645684
160MOS0.29455495
161JAK30.28879764

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.38327267
2Collecting duct acid secretion_Homo sapiens_hsa049662.46036268
3Nicotine addiction_Homo sapiens_hsa050332.25285806
4Olfactory transduction_Homo sapiens_hsa047402.10808596
5Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.86933896
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.83919785
7Taste transduction_Homo sapiens_hsa047421.83665659
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82692239
9Other glycan degradation_Homo sapiens_hsa005111.79057555
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.70754885
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67598116
12Dopaminergic synapse_Homo sapiens_hsa047281.65030710
13GABAergic synapse_Homo sapiens_hsa047271.64673676
14Rheumatoid arthritis_Homo sapiens_hsa053231.58963087
15Serotonergic synapse_Homo sapiens_hsa047261.57223612
16Phagosome_Homo sapiens_hsa041451.56362995
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.53922135
18Chronic myeloid leukemia_Homo sapiens_hsa052201.53848031
19Long-term potentiation_Homo sapiens_hsa047201.53774130
20Pancreatic cancer_Homo sapiens_hsa052121.52780954
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.51618699
22Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.51612115
23Type I diabetes mellitus_Homo sapiens_hsa049401.51431080
24Malaria_Homo sapiens_hsa051441.51220903
25Morphine addiction_Homo sapiens_hsa050321.50951624
26Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.47584464
27Circadian entrainment_Homo sapiens_hsa047131.47287276
28Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.44446888
29Cholinergic synapse_Homo sapiens_hsa047251.44275786
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.39562967
31Primary immunodeficiency_Homo sapiens_hsa053401.38164970
32Vibrio cholerae infection_Homo sapiens_hsa051101.37694627
33Platelet activation_Homo sapiens_hsa046111.37261392
34TNF signaling pathway_Homo sapiens_hsa046681.36325573
35Glutamatergic synapse_Homo sapiens_hsa047241.36072587
36Focal adhesion_Homo sapiens_hsa045101.34368730
37Hepatitis B_Homo sapiens_hsa051611.30789143
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.30700027
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29717010
40Long-term depression_Homo sapiens_hsa047301.24315623
41Small cell lung cancer_Homo sapiens_hsa052221.22391622
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.20954575
43Renal cell carcinoma_Homo sapiens_hsa052111.20857201
44Regulation of actin cytoskeleton_Homo sapiens_hsa048101.17083106
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17029619
46Acute myeloid leukemia_Homo sapiens_hsa052211.16546674
47Salmonella infection_Homo sapiens_hsa051321.16186053
48Oxidative phosphorylation_Homo sapiens_hsa001901.15397244
49Proteoglycans in cancer_Homo sapiens_hsa052051.15196861
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14126287
51Salivary secretion_Homo sapiens_hsa049701.13967856
52Insulin secretion_Homo sapiens_hsa049111.13562541
53Amoebiasis_Homo sapiens_hsa051461.13137998
54Antigen processing and presentation_Homo sapiens_hsa046121.11868015
55ECM-receptor interaction_Homo sapiens_hsa045121.09040832
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08971907
57Apoptosis_Homo sapiens_hsa042101.08760715
58Non-small cell lung cancer_Homo sapiens_hsa052231.08069938
59Graft-versus-host disease_Homo sapiens_hsa053321.07403554
60Allograft rejection_Homo sapiens_hsa053301.07284512
61Tuberculosis_Homo sapiens_hsa051521.06767934
62ErbB signaling pathway_Homo sapiens_hsa040121.06282548
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05650592
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05544899
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04332550
66Leishmaniasis_Homo sapiens_hsa051401.03925562
67Amphetamine addiction_Homo sapiens_hsa050311.01967826
68Legionellosis_Homo sapiens_hsa051341.01822967
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98365050
70Chemokine signaling pathway_Homo sapiens_hsa040620.97858812
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97510292
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.97014654
73Bladder cancer_Homo sapiens_hsa052190.96398923
74Osteoclast differentiation_Homo sapiens_hsa043800.96341840
75VEGF signaling pathway_Homo sapiens_hsa043700.94036290
76Calcium signaling pathway_Homo sapiens_hsa040200.92365881
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92093373
78GnRH signaling pathway_Homo sapiens_hsa049120.91624463
79Viral myocarditis_Homo sapiens_hsa054160.91614617
80Oxytocin signaling pathway_Homo sapiens_hsa049210.89331119
81Prolactin signaling pathway_Homo sapiens_hsa049170.88496382
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88479915
83T cell receptor signaling pathway_Homo sapiens_hsa046600.87386038
84Gastric acid secretion_Homo sapiens_hsa049710.85182331
85Viral carcinogenesis_Homo sapiens_hsa052030.83374088
86B cell receptor signaling pathway_Homo sapiens_hsa046620.82934922
87MAPK signaling pathway_Homo sapiens_hsa040100.82819782
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82368730
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82043551
90MicroRNAs in cancer_Homo sapiens_hsa052060.81823242
91Renin secretion_Homo sapiens_hsa049240.81747087
92Asthma_Homo sapiens_hsa053100.80109718
93Glioma_Homo sapiens_hsa052140.80038616
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79450827
95Endocytosis_Homo sapiens_hsa041440.78687055
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77993932
97Pertussis_Homo sapiens_hsa051330.77734354
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.77639440
99Alzheimers disease_Homo sapiens_hsa050100.77388657
100Melanoma_Homo sapiens_hsa052180.76137877
101Parkinsons disease_Homo sapiens_hsa050120.76114714
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76023262
103Adherens junction_Homo sapiens_hsa045200.74813897
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74020622
105Shigellosis_Homo sapiens_hsa051310.73591603
106Hepatitis C_Homo sapiens_hsa051600.73443757
107HTLV-I infection_Homo sapiens_hsa051660.73019523
108Endometrial cancer_Homo sapiens_hsa052130.72371209
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71763158
110Staphylococcus aureus infection_Homo sapiens_hsa051500.70369088
111Colorectal cancer_Homo sapiens_hsa052100.69962720
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68286466
113Measles_Homo sapiens_hsa051620.67557850
114Sphingolipid metabolism_Homo sapiens_hsa006000.67298271
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67004955
116cAMP signaling pathway_Homo sapiens_hsa040240.65608652
117Cardiac muscle contraction_Homo sapiens_hsa042600.64283159
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63741150
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63490438
120Herpes simplex infection_Homo sapiens_hsa051680.62655299
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62328910
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.61833542
123Ras signaling pathway_Homo sapiens_hsa040140.61776910
124Dorso-ventral axis formation_Homo sapiens_hsa043200.61655011
125Gap junction_Homo sapiens_hsa045400.60541622
126Pathways in cancer_Homo sapiens_hsa052000.60389634
127Estrogen signaling pathway_Homo sapiens_hsa049150.59488468
128Autoimmune thyroid disease_Homo sapiens_hsa053200.58745842
129Cocaine addiction_Homo sapiens_hsa050300.58290965
130Lysosome_Homo sapiens_hsa041420.58261814
131HIF-1 signaling pathway_Homo sapiens_hsa040660.57581836
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56944094
133Influenza A_Homo sapiens_hsa051640.56244926
134Hematopoietic cell lineage_Homo sapiens_hsa046400.55749683
135African trypanosomiasis_Homo sapiens_hsa051430.55640938
136Axon guidance_Homo sapiens_hsa043600.55152566
137Regulation of autophagy_Homo sapiens_hsa041400.55077953
138Inositol phosphate metabolism_Homo sapiens_hsa005620.54385639
139Toxoplasmosis_Homo sapiens_hsa051450.54273949
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54092397
141NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53432315
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.53420067
143RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53116663
144Rap1 signaling pathway_Homo sapiens_hsa040150.53061608
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.53040012
146Epstein-Barr virus infection_Homo sapiens_hsa051690.52962818
147Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51852310
148p53 signaling pathway_Homo sapiens_hsa041150.51552131
149Type II diabetes mellitus_Homo sapiens_hsa049300.51476814
150Prostate cancer_Homo sapiens_hsa052150.50731621

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