UBB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.05073072
2cullin deneddylation (GO:0010388)5.57376884
3establishment of protein localization to mitochondrial membrane (GO:0090151)5.56970932
4protein deneddylation (GO:0000338)5.34601732
5ATP synthesis coupled proton transport (GO:0015986)5.21261503
6energy coupled proton transport, down electrochemical gradient (GO:0015985)5.21261503
7respiratory electron transport chain (GO:0022904)4.37180903
8electron transport chain (GO:0022900)4.31829423
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.15052554
10protoporphyrinogen IX biosynthetic process (GO:0006782)4.12577566
11heme biosynthetic process (GO:0006783)3.99898472
12protoporphyrinogen IX metabolic process (GO:0046501)3.85537228
13synaptic vesicle docking involved in exocytosis (GO:0016081)3.77377889
14transferrin transport (GO:0033572)3.67647919
15negative regulation of dendrite morphogenesis (GO:0050774)3.55773063
16protein complex biogenesis (GO:0070271)3.48844751
17histone H2A acetylation (GO:0043968)3.45435663
18heme metabolic process (GO:0042168)3.44214798
19positive regulation of mitochondrial fission (GO:0090141)3.40969406
20* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.37724762
21protein localization to mitochondrion (GO:0070585)3.37280944
22negative regulation of inclusion body assembly (GO:0090084)3.37187515
23establishment of integrated proviral latency (GO:0075713)3.35252751
24GTP biosynthetic process (GO:0006183)3.33222129
25positive regulation of protein homodimerization activity (GO:0090073)3.32246225
26ferric iron transport (GO:0015682)3.32223449
27trivalent inorganic cation transport (GO:0072512)3.32223449
28proteasome assembly (GO:0043248)3.30755462
29pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.24535511
30male meiosis I (GO:0007141)3.24437982
31establishment of protein localization to mitochondrion (GO:0072655)3.22509552
32regulation of cellular amine metabolic process (GO:0033238)3.22369326
33mitochondrial respiratory chain complex assembly (GO:0033108)3.21860176
34* regulation of ligase activity (GO:0051340)3.21577750
35* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.21510472
36deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.21498534
37* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.20892116
38porphyrin-containing compound biosynthetic process (GO:0006779)3.20873737
39microtubule depolymerization (GO:0007019)3.20503760
40meiosis I (GO:0007127)3.20430008
41protein targeting to mitochondrion (GO:0006626)3.19650334
42synapsis (GO:0007129)3.17610122
43inositol phosphate catabolic process (GO:0071545)3.15970662
44purine nucleoside triphosphate biosynthetic process (GO:0009145)3.15691995
45oxidative phosphorylation (GO:0006119)3.15536901
46establishment of viral latency (GO:0019043)3.15074017
47purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.14612778
48DNA deamination (GO:0045006)3.14107802
49tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.13203850
50RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.13203850
51regulation of cilium movement (GO:0003352)3.12188248
52* positive regulation of cell cycle arrest (GO:0071158)3.10554727
53L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.09084294
54ribosomal small subunit assembly (GO:0000028)3.09047518
55purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.09045429
56* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.08761352
57cytochrome complex assembly (GO:0017004)3.08736817
58ATP biosynthetic process (GO:0006754)3.08736140
59regulation of cellular amino acid metabolic process (GO:0006521)3.08101952
60tetrapyrrole biosynthetic process (GO:0033014)3.07780450
61intraciliary transport (GO:0042073)3.07161450
62ATP hydrolysis coupled proton transport (GO:0015991)3.06581690
63energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.06581690
64NADH metabolic process (GO:0006734)3.06255483
65GDP-mannose metabolic process (GO:0019673)3.04845508
66* negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.04295812
67* negative regulation of ligase activity (GO:0051352)3.04295812
68* negative regulation of protein ubiquitination (GO:0031397)3.03356701
69nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02004942
70* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.01964144
71GMP metabolic process (GO:0046037)3.01766718
72protein localization to cilium (GO:0061512)3.00063720
73* DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.99219213
74mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.98629422
75mitochondrial respiratory chain complex I assembly (GO:0032981)2.98629422
76NADH dehydrogenase complex assembly (GO:0010257)2.98629422
77* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.96727447
78* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.96727447
79* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.96727447
80rRNA modification (GO:0000154)2.96532920
81* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.95491407
82* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.95491407
83DNA double-strand break processing (GO:0000729)2.94007401
847-methylguanosine mRNA capping (GO:0006370)2.93993296
85spliceosomal snRNP assembly (GO:0000387)2.91527784
86regulation of inclusion body assembly (GO:0090083)2.90144867
87de novo posttranslational protein folding (GO:0051084)2.89852741
88ubiquinone biosynthetic process (GO:0006744)2.89322823
89hydrogen ion transmembrane transport (GO:1902600)2.89250058
90hemoglobin metabolic process (GO:0020027)2.89126536
91* negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.88825852
92RNA capping (GO:0036260)2.88537727
937-methylguanosine RNA capping (GO:0009452)2.88537727
94sequestering of actin monomers (GO:0042989)2.87886069
95regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.87571408
96iron-sulfur cluster assembly (GO:0016226)2.87524545
97metallo-sulfur cluster assembly (GO:0031163)2.87524545
98exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87193788
99neurotransmitter-gated ion channel clustering (GO:0072578)2.85349469
100cytidine metabolic process (GO:0046087)2.84972966
101cytidine catabolic process (GO:0006216)2.84972966
102cytidine deamination (GO:0009972)2.84972966
103aerobic respiration (GO:0009060)2.84807464
104respiratory chain complex IV assembly (GO:0008535)2.84383439
105signal peptide processing (GO:0006465)2.83976663
106* signal transduction involved in cell cycle checkpoint (GO:0072395)2.82323425
107postreplication repair (GO:0006301)2.81714389
108* signal transduction involved in DNA damage checkpoint (GO:0072422)2.79614861
109* signal transduction involved in DNA integrity checkpoint (GO:0072401)2.79614861
110* positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.78906793
111deoxyribose phosphate biosynthetic process (GO:0046385)2.77950829
1122-deoxyribonucleotide biosynthetic process (GO:0009265)2.77950829
113de novo protein folding (GO:0006458)2.73264837
114protein refolding (GO:0042026)2.72416759
115protein neddylation (GO:0045116)2.70613887
116* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.69880314
117chaperone mediated protein folding requiring cofactor (GO:0051085)2.69626755
118protein-cofactor linkage (GO:0018065)2.69009091
119chaperone-mediated protein transport (GO:0072321)2.65349985
120histamine secretion (GO:0001821)2.62835684
121phagosome maturation (GO:0090382)2.62379535
122urinary tract smooth muscle contraction (GO:0014848)2.62183446
123viral mRNA export from host cell nucleus (GO:0046784)2.62003385
124DNA catabolic process, exonucleolytic (GO:0000738)2.61714333
125* positive regulation of ligase activity (GO:0051351)2.61585616
126purine nucleobase biosynthetic process (GO:0009113)2.58796589
127tricarboxylic acid cycle (GO:0006099)2.57914562
128maturation of 5.8S rRNA (GO:0000460)2.55011729
129binding of sperm to zona pellucida (GO:0007339)2.54133682
130transcription elongation from RNA polymerase III promoter (GO:0006385)2.52561881
131termination of RNA polymerase III transcription (GO:0006386)2.52561881
132postsynaptic membrane organization (GO:0001941)2.50668128
133mitochondrial genome maintenance (GO:0000002)2.50014448
134* regulation of ubiquitin-protein transferase activity (GO:0051438)2.48665782
135piRNA metabolic process (GO:0034587)2.48119632
136protein K11-linked ubiquitination (GO:0070979)2.48079839
137regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.47312486
138regulation of mitotic spindle checkpoint (GO:1903504)2.47312486
139negative regulation of dendrite development (GO:2000171)2.46353033
140regulation of synaptic vesicle exocytosis (GO:2000300)2.45986678
141sperm-egg recognition (GO:0035036)2.45776696
142* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.44714209
143nucleobase biosynthetic process (GO:0046112)2.44414529
144misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.44370400
145regulation of mitochondrial fission (GO:0090140)2.42563255
146synaptic vesicle exocytosis (GO:0016079)2.40956371
147regulation of synaptic vesicle transport (GO:1902803)2.40800480
148protein polyglutamylation (GO:0018095)2.40086145
149regulation of mitochondrial translation (GO:0070129)2.39955711
150guanosine-containing compound biosynthetic process (GO:1901070)2.39344292
151deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.38915430

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.55696403
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.09832378
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.00094452
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.47256695
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.23246004
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.20422171
7* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.06719313
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.04799136
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.00051277
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.91818655
11THAP11_20581084_ChIP-Seq_MESCs_Mouse2.76827761
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.71961097
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.71472231
14* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.68880601
15* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.61424649
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.60209122
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.42797074
18GBX2_23144817_ChIP-Seq_PC3_Human2.34717919
19YY1_21170310_ChIP-Seq_MESCs_Mouse2.31079428
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29322981
21* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18792784
22* VDR_23849224_ChIP-Seq_CD4+_Human2.17362855
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14495402
24CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.11113279
25* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06687038
26BP1_19119308_ChIP-ChIP_Hs578T_Human2.03424413
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95312968
28* FOXP3_21729870_ChIP-Seq_TREG_Human1.90253841
29E2F7_22180533_ChIP-Seq_HELA_Human1.89523068
30* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.88698083
31* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.84951708
32GABP_19822575_ChIP-Seq_HepG2_Human1.83377202
33* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.79587888
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78252820
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75391690
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71258923
37TAF15_26573619_Chip-Seq_HEK293_Human1.70753113
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67449841
39* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66909048
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62689406
41DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.61357734
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.60298875
43ELK1_19687146_ChIP-ChIP_HELA_Human1.57759654
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56709373
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56424526
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54326147
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.53587354
48DCP1A_22483619_ChIP-Seq_HELA_Human1.51961982
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.50302232
50* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.48528994
51CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47747543
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47293759
53* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47099606
54* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46116460
55SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.44892826
56* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42595122
57* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40598274
58EZH2_22144423_ChIP-Seq_EOC_Human1.38619507
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35832237
60CIITA_25753668_ChIP-Seq_RAJI_Human1.32763767
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.32616195
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31279537
63* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.30406131
64* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28864595
65MYC_18555785_ChIP-Seq_MESCs_Mouse1.26939344
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25033508
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24492505
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18190741
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17370413
70* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15993332
71ZNF274_21170338_ChIP-Seq_K562_Hela1.12297103
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11998839
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11606827
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11118940
75ELF1_20517297_ChIP-Seq_JURKAT_Human1.09190949
76RNF2_27304074_Chip-Seq_NSC_Mouse1.08157167
77* YY1_22570637_ChIP-Seq_MALME-3M_Human1.07043317
78* XRN2_22483619_ChIP-Seq_HELA_Human1.06495858
79MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06397914
80* BCL6_27268052_Chip-Seq_Bcells_Human1.05268870
81* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05236114
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04585503
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02757770
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02199984
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01827751
86* TTF2_22483619_ChIP-Seq_HELA_Human1.01286649
87SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01109549
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00911981
89* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00764385
90REST_21632747_ChIP-Seq_MESCs_Mouse1.00538952
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00148775
92FUS_26573619_Chip-Seq_HEK293_Human0.98777274
93* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98734536
94RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98333234
95REST_18959480_ChIP-ChIP_MESCs_Mouse0.97653775
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95993068
97VDR_22108803_ChIP-Seq_LS180_Human0.95716137
98IRF1_19129219_ChIP-ChIP_H3396_Human0.95597182
99CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94307482
100RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93981021
101GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93672571
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93619390
103* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91382038
104* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91102815
105ELK1_22589737_ChIP-Seq_MCF10A_Human0.90335114
106CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90267668
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89896177
108SOX9_26525672_Chip-Seq_HEART_Mouse0.89453924
109CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88162084
110ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87974106
111CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87764991
112* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86919738
113HTT_18923047_ChIP-ChIP_STHdh_Human0.86457048
114HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86420614
115* FOXP1_21924763_ChIP-Seq_HESCs_Human0.85557990
116* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85553349
117EWS_26573619_Chip-Seq_HEK293_Human0.85341738
118P300_19829295_ChIP-Seq_ESCs_Human0.85136027
119KDM5A_27292631_Chip-Seq_BREAST_Human0.84877309
120MYC_18940864_ChIP-ChIP_HL60_Human0.84335717
121PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84308795
122TP53_22573176_ChIP-Seq_HFKS_Human0.84201578
123* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84046184
124CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83773764
125PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83102969
126PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82998586
127* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82914869
128FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81242677
129CTCF_26484167_Chip-Seq_Bcells_Mouse0.81216015
130NOTCH1_21737748_ChIP-Seq_TLL_Human0.80878260
131* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.80482297
132CTCF_20526341_ChIP-Seq_ESCs_Human0.79341349
133* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79253193
134ERA_21632823_ChIP-Seq_H3396_Human0.78898319
135LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.76356887

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.03789346
2MP0008877_abnormal_DNA_methylation3.83190805
3MP0001986_abnormal_taste_sensitivity3.32220046
4MP0003136_yellow_coat_color3.29144438
5MP0003806_abnormal_nucleotide_metabolis2.93082351
6MP0003122_maternal_imprinting2.87946396
7MP0005646_abnormal_pituitary_gland2.87653599
8MP0006036_abnormal_mitochondrial_physio2.64727514
9MP0002736_abnormal_nociception_after2.63052493
10MP0001188_hyperpigmentation2.51182010
11MP0008058_abnormal_DNA_repair2.48721935
12MP0002277_abnormal_respiratory_mucosa2.47483301
13MP0003880_abnormal_central_pattern2.46176960
14MP0003186_abnormal_redox_activity2.35366593
15MP0001968_abnormal_touch/_nociception2.33314198
16MP0002876_abnormal_thyroid_physiology2.33096998
17MP0003121_genomic_imprinting2.27707740
18MP0003123_paternal_imprinting2.24312173
19MP0009697_abnormal_copulation2.21417428
20MP0002735_abnormal_chemical_nociception2.18950317
21MP0008007_abnormal_cellular_replicative2.17721926
22MP0006035_abnormal_mitochondrial_morpho2.12416106
23MP0004147_increased_porphyrin_level1.99163793
24MP0006292_abnormal_olfactory_placode1.91514966
25MP0005410_abnormal_fertilization1.91086881
26MP0003693_abnormal_embryo_hatching1.89948214
27MP0010094_abnormal_chromosome_stability1.89400263
28MP0003183_abnormal_peptide_metabolism1.85900247
29MP0008995_early_reproductive_senescence1.83538553
30MP0003718_maternal_effect1.76104414
31MP0003879_abnormal_hair_cell1.75803042
32MP0009046_muscle_twitch1.69290751
33MP0001984_abnormal_olfaction1.67847045
34MP0008260_abnormal_autophagy1.57717941
35MP0009745_abnormal_behavioral_response1.55282141
36MP0000015_abnormal_ear_pigmentation1.50572378
37MP0004859_abnormal_synaptic_plasticity1.50236265
38MP0003635_abnormal_synaptic_transmissio1.48032313
39MP0006072_abnormal_retinal_apoptosis1.46655535
40MP0003943_abnormal_hepatobiliary_system1.45708458
41MP0006276_abnormal_autonomic_nervous1.45558667
42MP0005645_abnormal_hypothalamus_physiol1.45427037
43MP0002928_abnormal_bile_duct1.45346732
44MP0002063_abnormal_learning/memory/cond1.44563293
45MP0002734_abnormal_mechanical_nocicepti1.44491855
46MP0002653_abnormal_ependyma_morphology1.43709713
47MP0002160_abnormal_reproductive_system1.42537742
48MP0003786_premature_aging1.40403189
49MP0001529_abnormal_vocalization1.39342077
50MP0003077_abnormal_cell_cycle1.37412907
51MP0002572_abnormal_emotion/affect_behav1.36590031
52MP0003656_abnormal_erythrocyte_physiolo1.36387103
53MP0009379_abnormal_foot_pigmentation1.35027442
54MP0002272_abnormal_nervous_system1.32880023
55MP0002064_seizures1.32543209
56MP0003011_delayed_dark_adaptation1.32291834
57MP0008875_abnormal_xenobiotic_pharmacok1.31297412
58MP0001485_abnormal_pinna_reflex1.31046026
59MP0002822_catalepsy1.30798803
60MP0005671_abnormal_response_to1.30419484
61MP0004957_abnormal_blastocyst_morpholog1.28171081
62MP0005174_abnormal_tail_pigmentation1.27156256
63MP0003763_abnormal_thymus_physiology1.26796121
64MP0010386_abnormal_urinary_bladder1.25881790
65MP0000678_abnormal_parathyroid_gland1.24692071
66MP0004142_abnormal_muscle_tone1.23609937
67* MP0001929_abnormal_gametogenesis1.23187141
68MP0002638_abnormal_pupillary_reflex1.21593768
69MP0003111_abnormal_nucleus_morphology1.21589387
70* MP0003698_abnormal_male_reproductive1.21141846
71MP0005389_reproductive_system_phenotype1.20244899
72MP0006054_spinal_hemorrhage1.20211279
73MP0005636_abnormal_mineral_homeostasis1.20103666
74MP0000681_abnormal_thyroid_gland1.18585083
75MP0008872_abnormal_physiological_respon1.14428659
76MP0005075_abnormal_melanosome_morpholog1.14036375
77* MP0002210_abnormal_sex_determination1.09880660
78MP0001919_abnormal_reproductive_system1.09109685
79MP0002751_abnormal_autonomic_nervous1.07959175
80MP0001905_abnormal_dopamine_level1.07922531
81MP0002067_abnormal_sensory_capabilities1.06424802
82MP0005084_abnormal_gallbladder_morpholo1.05204086
83MP0005083_abnormal_biliary_tract1.03759619
84MP0004808_abnormal_hematopoietic_stem0.99923669
85MP0002396_abnormal_hematopoietic_system0.99081873
86MP0001764_abnormal_homeostasis0.98946630
87MP0001970_abnormal_pain_threshold0.98509137
88MP0005377_hearing/vestibular/ear_phenot0.98046403
89MP0003878_abnormal_ear_physiology0.98046403
90MP0002102_abnormal_ear_morphology0.96500551
91MP0005085_abnormal_gallbladder_physiolo0.96063612
92MP0004742_abnormal_vestibular_system0.95939717
93MP0009780_abnormal_chondrocyte_physiolo0.94065377
94MP0005423_abnormal_somatic_nervous0.93450791
95MP0002095_abnormal_skin_pigmentation0.92684120
96MP0002163_abnormal_gland_morphology0.92627045
97MP0004811_abnormal_neuron_physiology0.92155130
98MP0008932_abnormal_embryonic_tissue0.91010172
99MP0000372_irregular_coat_pigmentation0.90832527
100MP0002557_abnormal_social/conspecific_i0.90832525
101MP0003724_increased_susceptibility_to0.90257205
102MP0001501_abnormal_sleep_pattern0.89054367
103MP0001293_anophthalmia0.88774946
104MP0005171_absent_coat_pigmentation0.86620167
105MP0000358_abnormal_cell_content/0.85506343
106MP0002132_abnormal_respiratory_system0.83667704
107MP0005499_abnormal_olfactory_system0.82965369
108MP0005394_taste/olfaction_phenotype0.82965369
109MP0002733_abnormal_thermal_nociception0.81416722
110MP0005253_abnormal_eye_physiology0.79896113
111MP0000313_abnormal_cell_death0.79214729
112MP0008873_increased_physiological_sensi0.79208182
113* MP0001145_abnormal_male_reproductive0.77398867
114* MP0000653_abnormal_sex_gland0.77359775
115MP0004270_analgesia0.76987601
116MP0003866_abnormal_defecation0.76324526
117MP0001835_abnormal_antigen_presentation0.76084893
118MP0000631_abnormal_neuroendocrine_gland0.76078657
119* MP0001119_abnormal_female_reproductive0.75582240
120MP0002184_abnormal_innervation0.74731321
121MP0009333_abnormal_splenocyte_physiolog0.74411533
122MP0008789_abnormal_olfactory_epithelium0.74283908
123MP0008057_abnormal_DNA_replication0.73620382
124MP0000689_abnormal_spleen_morphology0.73553299
125MP0002722_abnormal_immune_system0.72338071
126MP0005319_abnormal_enzyme/_coenzyme0.71729226
127MP0002019_abnormal_tumor_incidence0.71538817
128MP0004782_abnormal_surfactant_physiolog0.71321191
129MP0005551_abnormal_eye_electrophysiolog0.70511438
130MP0000013_abnormal_adipose_tissue0.69583387
131MP0000703_abnormal_thymus_morphology0.69497512
132MP0002398_abnormal_bone_marrow0.69431376
133MP0002420_abnormal_adaptive_immunity0.69278692
134MP0005025_abnormal_response_to0.68771257
135MP0004133_heterotaxia0.68702303
136MP0002938_white_spotting0.68670118
137MP0008569_lethality_at_weaning0.68493777
138MP0008004_abnormal_stomach_pH0.67795702
139* MP0002161_abnormal_fertility/fecundity0.67019031
140MP0003315_abnormal_perineum_morphology0.65978799
141MP0001270_distended_abdomen0.63144918
142MP0009785_altered_susceptibility_to0.61749915

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hair whorl (HP:0010721)4.88895080
2Hypochromic microcytic anemia (HP:0004840)4.30150294
3Abnormality of the heme biosynthetic pathway (HP:0010472)4.03745263
4Medial flaring of the eyebrow (HP:0010747)3.64568970
5Nephrogenic diabetes insipidus (HP:0009806)3.44137570
6Increased intramyocellular lipid droplets (HP:0012240)3.37873160
7Congenital primary aphakia (HP:0007707)3.29951159
8Hepatocellular necrosis (HP:0001404)3.23775883
9Gait imbalance (HP:0002141)3.22699936
10Epileptic encephalopathy (HP:0200134)3.18759200
11Increased hepatocellular lipid droplets (HP:0006565)3.13741664
12Focal motor seizures (HP:0011153)3.12445867
13Hypothermia (HP:0002045)3.10121827
14Cerebral edema (HP:0002181)3.05093266
15Type 2 muscle fiber atrophy (HP:0003554)2.99294556
16Abnormal mitochondria in muscle tissue (HP:0008316)2.97047527
17True hermaphroditism (HP:0010459)2.96171156
18Poor suck (HP:0002033)2.95962940
19Type I transferrin isoform profile (HP:0003642)2.94248748
20Acute necrotizing encephalopathy (HP:0006965)2.89272657
21Increased muscle lipid content (HP:0009058)2.87620524
22Atonic seizures (HP:0010819)2.86515157
23Pancreatic fibrosis (HP:0100732)2.82676939
24Lipid accumulation in hepatocytes (HP:0006561)2.80672104
25Mitochondrial inheritance (HP:0001427)2.79446903
26Hyperventilation (HP:0002883)2.78818214
27Poor coordination (HP:0002370)2.76163897
28Abnormal number of erythroid precursors (HP:0012131)2.68814724
29Renal Fanconi syndrome (HP:0001994)2.67141513
30Absent/shortened dynein arms (HP:0200106)2.65171108
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.65171108
32Febrile seizures (HP:0002373)2.65043674
33Hepatic necrosis (HP:0002605)2.62988129
34Increased CSF lactate (HP:0002490)2.59259093
35Abnormality of the anterior horn cell (HP:0006802)2.57616955
36Degeneration of anterior horn cells (HP:0002398)2.57616955
37Oligomenorrhea (HP:0000876)2.54602548
38Failure to thrive in infancy (HP:0001531)2.53056494
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.49208578
40Respiratory failure (HP:0002878)2.48527418
41Optic disc pallor (HP:0000543)2.40527140
42Neuroendocrine neoplasm (HP:0100634)2.39808224
43Muscle fiber atrophy (HP:0100295)2.37290597
44Aplastic anemia (HP:0001915)2.37055019
45Birth length less than 3rd percentile (HP:0003561)2.36231452
46Abnormality of cells of the erythroid lineage (HP:0012130)2.35757690
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.34430382
48Leukodystrophy (HP:0002415)2.34320718
49Cholelithiasis (HP:0001081)2.31715879
50Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.30293254
51Decreased activity of mitochondrial respiratory chain (HP:0008972)2.30293254
52Pheochromocytoma (HP:0002666)2.28459117
53Emotional lability (HP:0000712)2.27411134
54Abnormality of the labia minora (HP:0012880)2.27061280
55Progressive macrocephaly (HP:0004481)2.24408391
56Lethargy (HP:0001254)2.23360764
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.22722935
58Pancytopenia (HP:0001876)2.22025171
59Abnormal gallbladder morphology (HP:0012437)2.21516879
60Abnormal respiratory motile cilium morphology (HP:0005938)2.20566035
61Abnormal respiratory epithelium morphology (HP:0012253)2.20566035
62Abnormal protein N-linked glycosylation (HP:0012347)2.20491010
63Abnormal protein glycosylation (HP:0012346)2.20491010
64Abnormal glycosylation (HP:0012345)2.20491010
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.20491010
66Increased serum lactate (HP:0002151)2.20251781
67Pancreatic cysts (HP:0001737)2.17962896
68Hypoplasia of the capital femoral epiphysis (HP:0003090)2.16120471
69Exertional dyspnea (HP:0002875)2.15782282
70Broad foot (HP:0001769)2.15420395
71Tongue fasciculations (HP:0001308)2.15413753
72X-linked dominant inheritance (HP:0001423)2.13760174
73Macrocytic anemia (HP:0001972)2.13139486
74Respiratory difficulties (HP:0002880)2.10328960
75Genital tract atresia (HP:0001827)2.08778221
76Microvesicular hepatic steatosis (HP:0001414)2.08584881
77Hypochromic anemia (HP:0001931)2.08288661
78Vaginal atresia (HP:0000148)2.08227197
79Methylmalonic aciduria (HP:0012120)2.04649346
8011 pairs of ribs (HP:0000878)2.04380783
81Polyphagia (HP:0002591)2.02807545
82Abnormality of alanine metabolism (HP:0010916)2.02647444
83Hyperalaninemia (HP:0003348)2.02647444
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02647444
85Increased serum pyruvate (HP:0003542)2.01905539
86Abnormality of glycolysis (HP:0004366)2.01905539
873-Methylglutaconic aciduria (HP:0003535)2.01102043
88Abnormal respiratory motile cilium physiology (HP:0012261)2.00542656
89Dicarboxylic aciduria (HP:0003215)1.99004780
90Abnormality of dicarboxylic acid metabolism (HP:0010995)1.99004780
91CNS demyelination (HP:0007305)1.98863043
92Cholecystitis (HP:0001082)1.97845123
93Abnormal gallbladder physiology (HP:0012438)1.97845123
94Infertility (HP:0000789)1.96419297
95Methylmalonic acidemia (HP:0002912)1.96166644
96Microcytic anemia (HP:0001935)1.95228948
97Neoplasm of the adrenal gland (HP:0100631)1.92599323
98Protruding tongue (HP:0010808)1.92448379
99Lactic acidosis (HP:0003128)1.91860719
100Progressive microcephaly (HP:0000253)1.91467969
101Acute encephalopathy (HP:0006846)1.90283242
102Agnosia (HP:0010524)1.89718244
103Unsteady gait (HP:0002317)1.88842604
104Hyperglycinemia (HP:0002154)1.87791124
105Molar tooth sign on MRI (HP:0002419)1.87694424
106Abnormality of midbrain morphology (HP:0002418)1.87694424
107Microretrognathia (HP:0000308)1.87563527
108Sclerocornea (HP:0000647)1.87522218
109Atrophy/Degeneration involving motor neurons (HP:0007373)1.85694785
110Spinal canal stenosis (HP:0003416)1.85392110
111Spastic paraparesis (HP:0002313)1.84361924
112Abnormal ciliary motility (HP:0012262)1.83697789
113Cerebral hypomyelination (HP:0006808)1.83380508
114Long foot (HP:0001833)1.80814212
115Large for gestational age (HP:0001520)1.79341162
116Exercise intolerance (HP:0003546)1.79103816
117Nephroblastoma (Wilms tumor) (HP:0002667)1.78958799
118Abnormal spermatogenesis (HP:0008669)1.78641841
119Postaxial hand polydactyly (HP:0001162)1.78416373
120Embryonal renal neoplasm (HP:0011794)1.77299979
121Rhinitis (HP:0012384)1.76665595
122Myokymia (HP:0002411)1.76663440
123Abnormality of the preputium (HP:0100587)1.76395325
124Menstrual irregularities (HP:0000858)1.76281339
125Optic nerve coloboma (HP:0000588)1.75574493
126Postaxial foot polydactyly (HP:0001830)1.75158260
127Absent epiphyses (HP:0010577)1.74025428
128Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.74025428
129Meckel diverticulum (HP:0002245)1.73999936
130Nephronophthisis (HP:0000090)1.72867587
131Abnormality of the ileum (HP:0001549)1.72843887
132Nausea (HP:0002018)1.72672107
133Chronic bronchitis (HP:0004469)1.72076618
134Stomatitis (HP:0010280)1.70755702
135Elevated erythrocyte sedimentation rate (HP:0003565)1.70377593
136Aplasia/Hypoplasia of the lens (HP:0008063)1.70059670
137Median cleft lip (HP:0000161)1.69564702
138Ragged-red muscle fibers (HP:0003200)1.69473005
139Neuroblastoma (HP:0003006)1.68709639
140Primitive neuroectodermal tumor (HP:0030065)1.68709639
141Neuroblastic tumors (HP:0004376)1.68709639
142Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.68709639
143Lissencephaly (HP:0001339)1.67642543
144Retinal dysplasia (HP:0007973)1.67438795
145Bone marrow hypocellularity (HP:0005528)1.66929295
146Delusions (HP:0000746)1.66890288
147Abnormality of renal resorption (HP:0011038)1.65281325
148Occipital encephalocele (HP:0002085)1.64704663
149Irregular epiphyses (HP:0010582)1.64578688
150Generalized aminoaciduria (HP:0002909)1.64334629
151Reticulocytopenia (HP:0001896)1.62433069
152Abnormality of the gallbladder (HP:0005264)1.61553042
153Increased IgM level (HP:0003496)1.59444060

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.85198530
2MAP3K124.47146117
3VRK24.34377574
4TSSK63.83910967
5MAPK153.75195361
6PNCK3.69729887
7CCNB13.42852508
8SIK33.34897758
9TESK23.06523568
10BUB12.96619549
11BCKDK2.94419244
12AKT32.93328261
13STK162.66283276
14PBK2.56270374
15MAP2K72.34496985
16DAPK12.19403468
17MAP3K112.16793556
18PRPF4B2.10492223
19PDK31.99752945
20PDK41.99752945
21CDK81.75752337
22TXK1.75118811
23SGK21.74677573
24VRK11.67163420
25EIF2AK11.66772570
26BMPR1B1.66157621
27PDK21.58781835
28MYLK1.57366433
29PLK21.56821530
30BRAF1.54536196
31LIMK11.50041788
32NME21.35368289
33CDK191.33167456
34ERBB31.30301435
35TIE11.26883404
36PLK31.23999526
37TESK11.21255502
38GRK61.20706439
39NTRK31.18166737
40PLK41.17625355
41NME11.16543472
42BRSK11.15205584
43ADRBK21.14025261
44MAPK131.10337245
45SGK4941.08969035
46SGK2231.08969035
47ACVR1B1.07508133
48EIF2AK31.05518819
49MAP4K21.03816593
50PIM21.02958168
51MAPKAPK51.02870352
52NUAK11.01286247
53PASK0.99350733
54BMPR20.99056134
55DYRK20.97385300
56TLK10.96625783
57CSNK1G30.96473043
58LRRK20.94247213
59NEK10.91955355
60MAP3K40.89908856
61SGK30.89766257
62DAPK20.87893119
63TGFBR10.87257488
64ARAF0.87048611
65TAOK30.85931953
66TTK0.85907534
67YES10.85564017
68BRSK20.85531589
69MINK10.85172949
70RPS6KA50.84870535
71SRPK10.84141833
72BCR0.83928870
73STK40.81015543
74FES0.74018798
75MAP2K60.72040240
76CAMKK20.70785565
77ZAK0.70573905
78TEC0.70395253
79CSNK1G20.67404087
80PRKCG0.67251638
81PRKD30.67209560
82MKNK20.66552558
83TNK20.64312320
84EPHA40.63076498
85CSNK1G10.62144272
86MKNK10.61444641
87IRAK40.61131997
88IKBKE0.60747480
89MAP3K140.60445774
90ZAP700.59978255
91PLK10.59822708
92NEK60.59189446
93TBK10.59137878
94KDR0.58658627
95WEE10.58485836
96SCYL20.57473773
97GRK10.56268705
98ABL20.56071835
99TRIM280.55836896
100ATR0.55535331
101RPS6KB10.55479578
102MUSK0.55045749
103RPS6KA20.53978394
104CSNK1A1L0.52247479
105INSRR0.50383686
106DYRK30.49337165
107CSNK2A20.47677758
108CDC70.47607625
109AURKB0.47351380
110CDK30.45444518
111AURKA0.45114666
112TAOK10.43017255
113RPS6KC10.43003646
114RPS6KL10.43003646
115WNK30.42054412
116PIM10.40628083
117OXSR10.40166664
118RPS6KA60.40097572
119TAOK20.40041493
120PAK40.38998608
121CDK180.38713060
122PINK10.36722440
123STK240.36242943
124MAP4K10.36218554
125MAP3K50.36189213
126MAPK70.35865441
127SYK0.35816171
128MAPKAPK30.33793579
129MAP2K20.33475370
130MAP3K30.33124837
131RAF10.32972427
132RIPK40.32425714
133STK38L0.32224848
134GRK70.31598853
135EIF2AK20.31528107
136PRKCQ0.31417029
137CSNK2A10.30852797
138PTK2B0.30745343
139ADRBK10.30420003
140PRKCE0.29427595
141GRK50.29092667
142AKT20.27913500
143LYN0.27430683
144CLK10.25987781
145ITK0.25781267
146PAK10.25444096
147IKBKB0.25435786
148KIT0.23142880
149MST40.22870259
150MAP2K40.21465621
151PRKCI0.20741327

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.04881667
2Collecting duct acid secretion_Homo sapiens_hsa049663.30703481
3Synaptic vesicle cycle_Homo sapiens_hsa047213.18449070
4Ribosome_Homo sapiens_hsa030103.00169333
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.63781748
6Vibrio cholerae infection_Homo sapiens_hsa051102.29004152
7RNA polymerase_Homo sapiens_hsa030202.24742243
8Base excision repair_Homo sapiens_hsa034102.22006082
9Mismatch repair_Homo sapiens_hsa034302.20912715
10DNA replication_Homo sapiens_hsa030302.10730588
11Protein export_Homo sapiens_hsa030601.94028476
12SNARE interactions in vesicular transport_Homo sapiens_hsa041301.93770489
13Fatty acid elongation_Homo sapiens_hsa000621.90560061
14Oxidative phosphorylation_Homo sapiens_hsa001901.86078090
15Basal transcription factors_Homo sapiens_hsa030221.84321215
16Homologous recombination_Homo sapiens_hsa034401.70904653
17Nucleotide excision repair_Homo sapiens_hsa034201.70068143
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69044800
19Spliceosome_Homo sapiens_hsa030401.67053311
20Olfactory transduction_Homo sapiens_hsa047401.61133411
21Nicotine addiction_Homo sapiens_hsa050331.60557178
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60251064
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.57286570
24Folate biosynthesis_Homo sapiens_hsa007901.56851908
25Fanconi anemia pathway_Homo sapiens_hsa034601.56515864
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.55912664
27Pyrimidine metabolism_Homo sapiens_hsa002401.55628607
28RNA degradation_Homo sapiens_hsa030181.54291771
29Sulfur relay system_Homo sapiens_hsa041221.53969961
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52497969
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.52286013
32Rheumatoid arthritis_Homo sapiens_hsa053231.51087494
33Cell cycle_Homo sapiens_hsa041101.44184948
34Cardiac muscle contraction_Homo sapiens_hsa042601.39727600
35Purine metabolism_Homo sapiens_hsa002301.38991488
36RNA transport_Homo sapiens_hsa030131.38118407
37Propanoate metabolism_Homo sapiens_hsa006401.37102412
38Huntingtons disease_Homo sapiens_hsa050161.36898471
39Parkinsons disease_Homo sapiens_hsa050121.33066002
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31389101
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26951189
42Type I diabetes mellitus_Homo sapiens_hsa049401.26679917
43Peroxisome_Homo sapiens_hsa041461.23795219
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20938818
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.12107446
46Regulation of autophagy_Homo sapiens_hsa041401.11367064
47Morphine addiction_Homo sapiens_hsa050321.09471789
48Oocyte meiosis_Homo sapiens_hsa041141.09014991
49Circadian entrainment_Homo sapiens_hsa047131.07346044
50Amphetamine addiction_Homo sapiens_hsa050311.07308555
51Phagosome_Homo sapiens_hsa041451.05991861
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05709451
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04929711
54Taste transduction_Homo sapiens_hsa047421.04393121
55Epstein-Barr virus infection_Homo sapiens_hsa051691.01672421
56N-Glycan biosynthesis_Homo sapiens_hsa005100.99034315
57Butanoate metabolism_Homo sapiens_hsa006500.98195484
58Non-homologous end-joining_Homo sapiens_hsa034500.97304148
59Primary immunodeficiency_Homo sapiens_hsa053400.97181916
60Nitrogen metabolism_Homo sapiens_hsa009100.96943697
61Carbon metabolism_Homo sapiens_hsa012000.96439739
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.95659803
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94801810
64Glutathione metabolism_Homo sapiens_hsa004800.94694109
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94147784
66Fructose and mannose metabolism_Homo sapiens_hsa000510.93776450
67mRNA surveillance pathway_Homo sapiens_hsa030150.93329046
68Phototransduction_Homo sapiens_hsa047440.90424279
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87374823
70Dopaminergic synapse_Homo sapiens_hsa047280.87065215
71Legionellosis_Homo sapiens_hsa051340.86181548
72Insulin secretion_Homo sapiens_hsa049110.83700164
73GABAergic synapse_Homo sapiens_hsa047270.83689496
74Pyruvate metabolism_Homo sapiens_hsa006200.83365303
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81776229
76Biosynthesis of amino acids_Homo sapiens_hsa012300.80937129
77Metabolic pathways_Homo sapiens_hsa011000.80641853
78Alzheimers disease_Homo sapiens_hsa050100.80567174
79Long-term potentiation_Homo sapiens_hsa047200.79112506
80Sulfur metabolism_Homo sapiens_hsa009200.77418734
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77365629
82Antigen processing and presentation_Homo sapiens_hsa046120.75945075
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73323211
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72322084
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72244979
86One carbon pool by folate_Homo sapiens_hsa006700.71008585
87Allograft rejection_Homo sapiens_hsa053300.60869924
88Other glycan degradation_Homo sapiens_hsa005110.60680842
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60567414
90Steroid biosynthesis_Homo sapiens_hsa001000.59859545
91Shigellosis_Homo sapiens_hsa051310.58748344
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58647100
93Serotonergic synapse_Homo sapiens_hsa047260.56800431
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55635008
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54494316
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51422943
97Autoimmune thyroid disease_Homo sapiens_hsa053200.50906494
98Galactose metabolism_Homo sapiens_hsa000520.49786512
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.48132137
100Fatty acid metabolism_Homo sapiens_hsa012120.47658534
101Tryptophan metabolism_Homo sapiens_hsa003800.47127398
102Calcium signaling pathway_Homo sapiens_hsa040200.47004241
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.46563048
104Measles_Homo sapiens_hsa051620.45238324
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44829168
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44401923
107beta-Alanine metabolism_Homo sapiens_hsa004100.44131440
108Phenylalanine metabolism_Homo sapiens_hsa003600.41739564
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.41059547
110Chemical carcinogenesis_Homo sapiens_hsa052040.40795943
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39967957
112Graft-versus-host disease_Homo sapiens_hsa053320.39716024
113Vitamin B6 metabolism_Homo sapiens_hsa007500.39096677
114Circadian rhythm_Homo sapiens_hsa047100.38489967
115Influenza A_Homo sapiens_hsa051640.37920604
116Glutamatergic synapse_Homo sapiens_hsa047240.37679499
117Alcoholism_Homo sapiens_hsa050340.37515632
118Fatty acid degradation_Homo sapiens_hsa000710.35228329
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34894921
120Pentose phosphate pathway_Homo sapiens_hsa000300.34679024
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34593582
122Cholinergic synapse_Homo sapiens_hsa047250.33287821
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33155406
124Hematopoietic cell lineage_Homo sapiens_hsa046400.31147061
125Tyrosine metabolism_Homo sapiens_hsa003500.30888486
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30548887
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30247133
128Colorectal cancer_Homo sapiens_hsa052100.29918563
129Arachidonic acid metabolism_Homo sapiens_hsa005900.29750387
130Herpes simplex infection_Homo sapiens_hsa051680.29390258
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29166521
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.29103076
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28657742
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27741851
135Arginine and proline metabolism_Homo sapiens_hsa003300.27219865
136Selenocompound metabolism_Homo sapiens_hsa004500.26237964
137HTLV-I infection_Homo sapiens_hsa051660.25608631
138Cocaine addiction_Homo sapiens_hsa050300.24434112
139Asthma_Homo sapiens_hsa053100.24415478
140Thyroid cancer_Homo sapiens_hsa052160.24255174
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23502243
142Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22001307
143Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21952137
144Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21551937

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