UBBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of growth hormone secretion (GO:0060124)6.75910335
2ganglion development (GO:0061548)5.95822092
3negative regulation of oligodendrocyte differentiation (GO:0048715)5.88147616
4growth hormone secretion (GO:0030252)5.56734824
5regulation of timing of cell differentiation (GO:0048505)5.35861248
6DNA deamination (GO:0045006)5.32232023
7cerebral cortex neuron differentiation (GO:0021895)5.13810434
8response to folic acid (GO:0051593)5.09501311
9auditory behavior (GO:0031223)5.02768361
10regulation of development, heterochronic (GO:0040034)4.67135956
11spinal cord association neuron differentiation (GO:0021527)4.59936951
12reflex (GO:0060004)4.39288720
13lung secretory cell differentiation (GO:0061140)4.33749973
14protein neddylation (GO:0045116)4.14238407
15musculoskeletal movement (GO:0050881)4.08329744
16multicellular organismal movement (GO:0050879)4.08329744
17cullin deneddylation (GO:0010388)4.07655934
18regulation of growth hormone secretion (GO:0060123)4.03042891
19regulation of transcription involved in cell fate commitment (GO:0060850)3.95893521
20positive regulation of circadian rhythm (GO:0042753)3.93700489
21sympathetic nervous system development (GO:0048485)3.93262886
22protein deneddylation (GO:0000338)3.92991725
23neuroblast proliferation (GO:0007405)3.85929839
24mechanosensory behavior (GO:0007638)3.83403056
25synaptic vesicle maturation (GO:0016188)3.79067167
26pyrimidine nucleobase catabolic process (GO:0006208)3.71837947
27postsynaptic membrane organization (GO:0001941)3.69803001
28behavioral response to nicotine (GO:0035095)3.67945012
29regulation of circadian sleep/wake cycle (GO:0042749)3.67684019
30regulation of circadian sleep/wake cycle, sleep (GO:0045187)3.67684019
31gamma-aminobutyric acid transport (GO:0015812)3.55439524
32protein complex biogenesis (GO:0070271)3.40159453
33response to auditory stimulus (GO:0010996)3.39892415
34dendritic spine morphogenesis (GO:0060997)3.39822953
35olfactory bulb development (GO:0021772)3.38146665
36protein-cofactor linkage (GO:0018065)3.31239025
37neuron fate commitment (GO:0048663)3.25589057
38positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.24237928
39negative regulation of Notch signaling pathway (GO:0045746)3.23264782
40energy coupled proton transport, down electrochemical gradient (GO:0015985)3.20931802
41ATP synthesis coupled proton transport (GO:0015986)3.20931802
42cytidine deamination (GO:0009972)3.16632574
43cytidine metabolic process (GO:0046087)3.16632574
44cytidine catabolic process (GO:0006216)3.16632574
45mitochondrial respiratory chain complex I assembly (GO:0032981)3.16587407
46NADH dehydrogenase complex assembly (GO:0010257)3.16587407
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.16587407
48response to gravity (GO:0009629)3.15059678
49forebrain neuron differentiation (GO:0021879)3.13141242
50glandular epithelial cell differentiation (GO:0002067)3.12271651
51regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.12231387
52negative regulation of glial cell differentiation (GO:0045686)3.11412783
53circadian sleep/wake cycle process (GO:0022410)3.08710566
54neuron fate specification (GO:0048665)3.01418749
55RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.00802557
56tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.00802557
57mitochondrial respiratory chain complex assembly (GO:0033108)2.97507516
58nucleobase catabolic process (GO:0046113)2.96958140
59negative regulation of synaptic transmission, GABAergic (GO:0032229)2.96652653
60platelet dense granule organization (GO:0060155)2.96183094
61negative regulation of JAK-STAT cascade (GO:0046426)2.91566971
62negative regulation of cAMP-mediated signaling (GO:0043951)2.90612261
63chaperone-mediated protein transport (GO:0072321)2.90460842
64positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.89412551
65positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.88243846
66transmission of nerve impulse (GO:0019226)2.88005455
67mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.86985535
68hippocampus development (GO:0021766)2.82318339
69regulation of synapse structural plasticity (GO:0051823)2.80037875
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.79733884
71regulation of action potential (GO:0098900)2.79265339
72central nervous system neuron development (GO:0021954)2.78103868
73oligodendrocyte development (GO:0014003)2.73245405
74water-soluble vitamin biosynthetic process (GO:0042364)2.72242956
75detection of light stimulus involved in sensory perception (GO:0050962)2.70473732
76detection of light stimulus involved in visual perception (GO:0050908)2.70473732
77fucose catabolic process (GO:0019317)2.69736148
78L-fucose metabolic process (GO:0042354)2.69736148
79L-fucose catabolic process (GO:0042355)2.69736148
80regulation of oligodendrocyte differentiation (GO:0048713)2.67307820
81neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.66170573
82regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.65912567
83regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.65912567
84sulfation (GO:0051923)2.59577599
85circadian behavior (GO:0048512)2.59536301
86electron transport chain (GO:0022900)2.55314658
87respiratory electron transport chain (GO:0022904)2.54594170
88establishment of mitochondrion localization (GO:0051654)2.53009214
89DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.52936018
90viral protein processing (GO:0019082)2.52684486
91aggressive behavior (GO:0002118)2.51593819
92negative regulation of mast cell activation (GO:0033004)2.50218303
93response to food (GO:0032094)2.46915905
94pyrimidine ribonucleoside catabolic process (GO:0046133)2.46563742
95regulation of rhodopsin mediated signaling pathway (GO:0022400)2.45793520
96glycine transport (GO:0015816)2.44740931
97striatum development (GO:0021756)2.42586093
98rhythmic behavior (GO:0007622)2.42319713
99signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.42136577
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.42136577

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.54238319
2EZH2_22144423_ChIP-Seq_EOC_Human3.46712764
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.76167591
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.66934247
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57602606
6VDR_22108803_ChIP-Seq_LS180_Human2.44113309
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.35645530
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.33229688
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.25381679
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.16402718
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.15233035
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13211698
13REST_21632747_ChIP-Seq_MESCs_Mouse2.11320986
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.09251917
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07773724
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.07006998
17GBX2_23144817_ChIP-Seq_PC3_Human2.02025346
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.98473110
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98007431
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88267235
21ZNF274_21170338_ChIP-Seq_K562_Hela1.82183342
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.81360558
23YY1_21170310_ChIP-Seq_MESCs_Mouse1.80701164
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80574085
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.80379177
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76555080
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.73023181
28IGF1R_20145208_ChIP-Seq_DFB_Human1.72542774
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.63571821
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54271096
31VDR_23849224_ChIP-Seq_CD4+_Human1.52129678
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.51687464
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49402880
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.46763891
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40464754
36TP53_22573176_ChIP-Seq_HFKS_Human1.40269203
37SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39648368
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39630166
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38074684
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.36279696
41IRF1_19129219_ChIP-ChIP_H3396_Human1.31541382
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30059890
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.27891027
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27882724
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.26303160
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26196744
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25606100
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.22532652
49PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21573412
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21328878
51CIITA_25753668_ChIP-Seq_RAJI_Human1.21022650
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20751867
53NCOR_22424771_ChIP-Seq_293T_Human1.19937331
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19124379
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17759151
56CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.16994221
57PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.15093705
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14018244
59CBP_20019798_ChIP-Seq_JUKART_Human1.14018244
60TAF2_19829295_ChIP-Seq_ESCs_Human1.12438863
61CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12226869
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11407644
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11377073
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11186720
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11026917
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11026917
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.10789709
68SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09313462
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08420602
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.08350735
71ELK1_19687146_ChIP-ChIP_HELA_Human1.06324262
72EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05824796
73TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05012174
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04722017
75AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02816889
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02715171
77EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01635881
78FOXH1_21741376_ChIP-Seq_EPCs_Human1.00811826
79THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00059718
80P300_19829295_ChIP-Seq_ESCs_Human0.98928775
81MYC_18940864_ChIP-ChIP_HL60_Human0.98906492
82FOXP3_21729870_ChIP-Seq_TREG_Human0.97619550
83FLI1_27457419_Chip-Seq_LIVER_Mouse0.97138817
84YY1_22570637_ChIP-Seq_MALME-3M_Human0.96952708
85FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96411421
86FOXA1_25329375_ChIP-Seq_VCAP_Human0.96411421
87GATA3_21878914_ChIP-Seq_MCF-7_Human0.95918245
88SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95733915
89MYC_19829295_ChIP-Seq_ESCs_Human0.94681255
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94673262
91KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.93680136
92KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.93680136
93KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.93680136
94NANOG_20526341_ChIP-Seq_ESCs_Human0.93602151
95SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93497867
96SOX2_19829295_ChIP-Seq_ESCs_Human0.92982516
97NANOG_19829295_ChIP-Seq_ESCs_Human0.92982516
98ERA_21632823_ChIP-Seq_H3396_Human0.92827398
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91973638
100RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91597588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy6.89450900
2MP0008789_abnormal_olfactory_epithelium3.59464438
3MP0006072_abnormal_retinal_apoptosis3.50144774
4MP0005646_abnormal_pituitary_gland2.85521290
5MP0005394_taste/olfaction_phenotype2.74576916
6MP0005499_abnormal_olfactory_system2.74576916
7MP0002138_abnormal_hepatobiliary_system2.59137306
8MP0001968_abnormal_touch/_nociception2.55054668
9MP0001529_abnormal_vocalization2.30309428
10MP0004885_abnormal_endolymph2.22402206
11MP0002095_abnormal_skin_pigmentation2.15753298
12MP0009745_abnormal_behavioral_response2.15423951
13MP0005423_abnormal_somatic_nervous2.12960987
14MP0002102_abnormal_ear_morphology2.10896876
15MP0002876_abnormal_thyroid_physiology2.07100543
16MP0002733_abnormal_thermal_nociception2.03548972
17MP0002735_abnormal_chemical_nociception1.98567368
18MP0001905_abnormal_dopamine_level1.96195381
19MP0008875_abnormal_xenobiotic_pharmacok1.87693487
20MP0006276_abnormal_autonomic_nervous1.86845004
21MP0005645_abnormal_hypothalamus_physiol1.86682838
22MP0002734_abnormal_mechanical_nocicepti1.79577384
23MP0004270_analgesia1.76572669
24MP0001986_abnormal_taste_sensitivity1.76165875
25MP0008872_abnormal_physiological_respon1.72771065
26MP0002272_abnormal_nervous_system1.71360118
27MP0001502_abnormal_circadian_rhythm1.67927518
28MP0005671_abnormal_response_to1.67505442
29MP0001970_abnormal_pain_threshold1.66458350
30MP0003635_abnormal_synaptic_transmissio1.66222423
31MP0002736_abnormal_nociception_after1.65365075
32MP0004142_abnormal_muscle_tone1.57391339
33MP0002751_abnormal_autonomic_nervous1.56061343
34MP0001984_abnormal_olfaction1.55909526
35MP0002064_seizures1.52524776
36MP0009046_muscle_twitch1.47980925
37MP0008877_abnormal_DNA_methylation1.46637887
38MP0005253_abnormal_eye_physiology1.44581371
39MP0005083_abnormal_biliary_tract1.43468022
40MP0004147_increased_porphyrin_level1.41668602
41MP0002572_abnormal_emotion/affect_behav1.40130810
42MP0003787_abnormal_imprinting1.39527856
43MP0001188_hyperpigmentation1.37055853
44MP0004924_abnormal_behavior1.35738328
45MP0005386_behavior/neurological_phenoty1.35738328
46MP0001348_abnormal_lacrimal_gland1.35365949
47MP0001486_abnormal_startle_reflex1.35364490
48MP0005551_abnormal_eye_electrophysiolog1.33933964
49MP0002063_abnormal_learning/memory/cond1.33560274
50MP0000013_abnormal_adipose_tissue1.32035057
51MP0001440_abnormal_grooming_behavior1.21213419
52MP0000631_abnormal_neuroendocrine_gland1.20216448
53MP0000049_abnormal_middle_ear1.18769780
54MP0002557_abnormal_social/conspecific_i1.18529761
55MP0001501_abnormal_sleep_pattern1.17511519
56MP0005084_abnormal_gallbladder_morpholo1.16954366
57MP0008775_abnormal_heart_ventricle1.15956394
58MP0002184_abnormal_innervation1.13597738
59MP0005360_urolithiasis1.13322574
60MP0004145_abnormal_muscle_electrophysio1.11855895
61MP0002638_abnormal_pupillary_reflex1.07564669
62MP0002909_abnormal_adrenal_gland1.06895292
63MP0004859_abnormal_synaptic_plasticity1.01806405
64MP0004811_abnormal_neuron_physiology1.00010849
65MP0003866_abnormal_defecation0.99781037
66MP0000569_abnormal_digit_pigmentation0.99012478
67MP0001835_abnormal_antigen_presentation0.98504798
68MP0005167_abnormal_blood-brain_barrier0.94644186
69MP0009780_abnormal_chondrocyte_physiolo0.92485988
70MP0001664_abnormal_digestion0.91923452
71MP0000955_abnormal_spinal_cord0.90040290
72MP0002067_abnormal_sensory_capabilities0.86910373
73MP0000778_abnormal_nervous_system0.83011909
74MP0002069_abnormal_eating/drinking_beha0.82803107
75MP0002882_abnormal_neuron_morphology0.81412581
76MP0001270_distended_abdomen0.80852843
77MP0004742_abnormal_vestibular_system0.80717921
78MP0006292_abnormal_olfactory_placode0.77946614
79MP0003880_abnormal_central_pattern0.77810196
80MP0000427_abnormal_hair_cycle0.77167022
81MP0000685_abnormal_immune_system0.74784821
82MP0003646_muscle_fatigue0.73441082
83MP0003786_premature_aging0.73145727
84MP0000230_abnormal_systemic_arterial0.71960424
85MP0002277_abnormal_respiratory_mucosa0.69820975
86MP0010386_abnormal_urinary_bladder0.68557416
87MP0003011_delayed_dark_adaptation0.68300719
88MP0009764_decreased_sensitivity_to0.67961302
89MP0002752_abnormal_somatic_nervous0.67057578
90MP0005377_hearing/vestibular/ear_phenot0.64940412
91MP0003878_abnormal_ear_physiology0.64940412
92MP0002837_dystrophic_cardiac_calcinosis0.64356254
93MP0005389_reproductive_system_phenotype0.63731157
94MP0002066_abnormal_motor_capabilities/c0.63650281
95MP0005670_abnormal_white_adipose0.62788611
96MP0002229_neurodegeneration0.62457968
97MP0009765_abnormal_xenobiotic_induced0.62448824
98MP0004215_abnormal_myocardial_fiber0.61399635
99MP0005448_abnormal_energy_balance0.59262166
100MP0001756_abnormal_urination0.58064855

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.43351316
2Mitochondrial inheritance (HP:0001427)3.41997981
3Hepatocellular necrosis (HP:0001404)3.37894079
4Pancreatic cysts (HP:0001737)3.22119923
5Hypoventilation (HP:0002791)3.15982869
6Hepatic necrosis (HP:0002605)3.10309468
7Abnormal mitochondria in muscle tissue (HP:0008316)3.08332322
8Increased CSF lactate (HP:0002490)3.08310086
9Progressive macrocephaly (HP:0004481)3.06968717
10Congenital stationary night blindness (HP:0007642)3.06451239
11Decreased electroretinogram (ERG) amplitude (HP:0000654)2.93131733
12Pancreatic fibrosis (HP:0100732)2.86496913
13Abolished electroretinogram (ERG) (HP:0000550)2.82694254
14Attenuation of retinal blood vessels (HP:0007843)2.76963422
15Acute encephalopathy (HP:0006846)2.76158081
16Mutism (HP:0002300)2.69296907
173-Methylglutaconic aciduria (HP:0003535)2.69043237
18True hermaphroditism (HP:0010459)2.67313755
19Stomach cancer (HP:0012126)2.66068773
20IgG deficiency (HP:0004315)2.60122556
21Abnormality of alanine metabolism (HP:0010916)2.59621291
22Hyperalaninemia (HP:0003348)2.59621291
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59621291
24Aplasia/hypoplasia of the uterus (HP:0008684)2.57498255
25Optic disc pallor (HP:0000543)2.53765776
26Progressive cerebellar ataxia (HP:0002073)2.53711726
27Myokymia (HP:0002411)2.49795123
28Congenital, generalized hypertrichosis (HP:0004540)2.48618992
29Delayed CNS myelination (HP:0002188)2.47548127
30Action tremor (HP:0002345)2.46804475
31Abnormality of the phalanges of the 2nd finger (HP:0009541)2.44474216
32Nephronophthisis (HP:0000090)2.39174164
33Conjunctival hamartoma (HP:0100780)2.39110526
34Torticollis (HP:0000473)2.38830199
35Anxiety (HP:0000739)2.37888803
36Abnormality of the renal cortex (HP:0011035)2.34812305
37Agitation (HP:0000713)2.30070598
38Broad-based gait (HP:0002136)2.29957740
39Increased serum lactate (HP:0002151)2.27715469
40Abnormal rod and cone electroretinograms (HP:0008323)2.25063918
41Constricted visual fields (HP:0001133)2.24664692
42Hypoproteinemia (HP:0003075)2.24053072
43Molar tooth sign on MRI (HP:0002419)2.23850992
44Abnormality of midbrain morphology (HP:0002418)2.23850992
45Aqueductal stenosis (HP:0002410)2.22964222
46Fibular aplasia (HP:0002990)2.22790859
47Palpebral edema (HP:0100540)2.21610634
48Hypoplasia of the uterus (HP:0000013)2.21366542
49Abnormality of the prostate (HP:0008775)2.17995380
50Abnormality of the middle phalanges of the toes (HP:0010183)2.17178932
51Absent speech (HP:0001344)2.16646921
52Epileptic encephalopathy (HP:0200134)2.16550201
53Cerebral edema (HP:0002181)2.15296149
54Type 2 muscle fiber atrophy (HP:0003554)2.14877188
55Limb dystonia (HP:0002451)2.13841059
56Neuroblastoma (HP:0003006)2.13308966
57Primitive neuroectodermal tumor (HP:0030065)2.13308966
58Neuroblastic tumors (HP:0004376)2.13308966
59Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.13308966
60Renal cortical cysts (HP:0000803)2.11474655
61Humeroradial synostosis (HP:0003041)2.10442669
62Synostosis involving the elbow (HP:0003938)2.10442669
63Methylmalonic acidemia (HP:0002912)2.09308893
64Abnormality of the renal medulla (HP:0100957)2.05283622
65Lactic acidosis (HP:0003128)2.04966338
66Progressive microcephaly (HP:0000253)2.04596966
67Pendular nystagmus (HP:0012043)2.01085513
68Hypsarrhythmia (HP:0002521)2.00018831
69Hypomagnesemia (HP:0002917)1.98772984
70Symphalangism affecting the phalanges of the hand (HP:0009773)1.98267359
71Prostate neoplasm (HP:0100787)1.96665313
72Furrowed tongue (HP:0000221)1.96660917
73Emotional lability (HP:0000712)1.95173791
74EEG with generalized epileptiform discharges (HP:0011198)1.94129863
75Hypothermia (HP:0002045)1.93521722
76Severe muscular hypotonia (HP:0006829)1.91431855
77Craniofacial dystonia (HP:0012179)1.91219440
78Generalized aminoaciduria (HP:0002909)1.90772408
79Cerebral hypomyelination (HP:0006808)1.89840639
80Methylmalonic aciduria (HP:0012120)1.89531418
81Abnormality of magnesium homeostasis (HP:0004921)1.88483072
82Elevated erythrocyte sedimentation rate (HP:0003565)1.86117403
83Focal dystonia (HP:0004373)1.85451907
84Absent septum pellucidum (HP:0001331)1.85058381
85Neuroendocrine neoplasm (HP:0100634)1.84746680
86Decreased central vision (HP:0007663)1.84281430
87Epileptiform EEG discharges (HP:0011182)1.84071670
88Type II lissencephaly (HP:0007260)1.78712802
89Hamartoma of the eye (HP:0010568)1.77902473
90Sclerocornea (HP:0000647)1.76649150
91CNS hypomyelination (HP:0003429)1.76528629
92Gaze-evoked nystagmus (HP:0000640)1.76493515
93Pachygyria (HP:0001302)1.75531734
94Poor speech (HP:0002465)1.74927794
95Congenital sensorineural hearing impairment (HP:0008527)1.74324528
962-3 toe syndactyly (HP:0004691)1.74111363
97Polyphagia (HP:0002591)1.73295510
98Absent rod-and cone-mediated responses on ERG (HP:0007688)1.71380298
99Inability to walk (HP:0002540)1.70928239
100Short tibia (HP:0005736)1.70697787

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK23.76342153
2PHKG23.23236986
3PHKG13.23236986
4BCKDK3.10350327
5TLK12.83673101
6MARK12.33506497
7PAK62.33441641
8TXK2.31125596
9ZAK2.23711111
10STK162.12221093
11CSNK1G22.09522489
12LIMK11.99701015
13DYRK21.95586460
14BMPR1B1.92243621
15FRK1.89714634
16VRK21.85820460
17GRK11.84610471
18CSNK1G31.83485396
19INSRR1.81434577
20NUAK11.70335401
21CASK1.67631595
22CSNK1A1L1.64477482
23MAP3K121.64225250
24ADRBK21.64187788
25MAP4K21.59355395
26TESK11.58553527
27TAOK31.55134660
28FGFR21.41319444
29CSNK1G11.39905573
30MAPK131.29527992
31PRKD31.27693004
32TNIK1.23016266
33DAPK21.22958629
34CDK81.21564948
35TIE11.19836757
36NTRK31.18636237
37MOS1.14968208
38MST41.10214236
39WNK41.10150052
40KDR1.09125231
41NME21.09000409
42PLK21.00938246
43PINK10.99677819
44TRIM280.94210852
45DAPK10.93943607
46MAP2K70.93478985
47LMTK20.89661269
48FES0.85056111
49MINK10.81192363
50VRK10.80504105
51PRKCE0.79978675
52NTRK20.78869369
53MAPKAPK30.77459207
54SYK0.75170442
55AURKA0.74719262
56MAP2K60.71779785
57ITK0.67907343
58EPHA30.67383886
59CDK90.66370269
60NEK90.65020865
61CAMKK20.64989284
62BCR0.63441325
63TAF10.62118142
64ADRBK10.62022878
65CAMKK10.59572205
66MAP3K40.58147586
67ERBB20.58045346
68GRK70.57037331
69KIT0.55558820
70PRKCI0.55178470
71SIK20.54568752
72RPS6KA20.54237744
73TEC0.52475797
74CAMK2D0.52015727
75SCYL20.51772345
76WNK30.51229106
77CSNK1A10.51056563
78NTRK10.50910064
79GRK50.49236392
80IKBKB0.48794091
81EIF2AK20.48557082
82RPS6KA50.48072711
83NME10.45515660
84TSSK60.44362150
85SIK30.43826524
86PRKCG0.43758754
87CDK190.42432572
88SGK4940.38427764
89SGK2230.38427764
90EPHB20.38147976
91MAP4K10.38092053
92OXSR10.37351451
93CDK50.36699433
94CAMK2A0.36116617
95PLK30.33590213
96ROCK10.31487431
97MATK0.30149015
98ABL20.30046861
99PRKACA0.29446411
100CCNB10.28768699

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.56608486
2Asthma_Homo sapiens_hsa053103.26717778
3Oxidative phosphorylation_Homo sapiens_hsa001903.14925010
4Autoimmune thyroid disease_Homo sapiens_hsa053202.78447928
5Allograft rejection_Homo sapiens_hsa053302.73181142
6Parkinsons disease_Homo sapiens_hsa050122.64078261
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.62916246
8Type I diabetes mellitus_Homo sapiens_hsa049402.57765706
9Graft-versus-host disease_Homo sapiens_hsa053322.53593152
10Phototransduction_Homo sapiens_hsa047442.49272253
11RNA polymerase_Homo sapiens_hsa030202.06563081
12Synaptic vesicle cycle_Homo sapiens_hsa047212.02950779
13Antigen processing and presentation_Homo sapiens_hsa046121.91783634
14Nitrogen metabolism_Homo sapiens_hsa009101.86975250
15Morphine addiction_Homo sapiens_hsa050321.82197027
16Nicotine addiction_Homo sapiens_hsa050331.78441368
17Cardiac muscle contraction_Homo sapiens_hsa042601.75099007
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.73173400
19Collecting duct acid secretion_Homo sapiens_hsa049661.72488013
20Rheumatoid arthritis_Homo sapiens_hsa053231.70170708
21Alzheimers disease_Homo sapiens_hsa050101.67465238
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62274449
23GABAergic synapse_Homo sapiens_hsa047271.61557546
24Huntingtons disease_Homo sapiens_hsa050161.57393478
25Primary immunodeficiency_Homo sapiens_hsa053401.56500230
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43285459
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39387259
28Caffeine metabolism_Homo sapiens_hsa002321.32064947
29Salivary secretion_Homo sapiens_hsa049701.27190117
30Dopaminergic synapse_Homo sapiens_hsa047281.22212877
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21121785
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.20763368
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16925832
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14872234
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.14733816
36Insulin secretion_Homo sapiens_hsa049111.14452866
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13918552
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13190235
39Protein export_Homo sapiens_hsa030601.08641710
40Sulfur metabolism_Homo sapiens_hsa009201.05952185
41Linoleic acid metabolism_Homo sapiens_hsa005911.02705283
42Circadian entrainment_Homo sapiens_hsa047131.02642535
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02595780
44Serotonergic synapse_Homo sapiens_hsa047261.00710438
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00336297
46RNA degradation_Homo sapiens_hsa030180.94012251
47Viral myocarditis_Homo sapiens_hsa054160.94000422
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89478083
49Olfactory transduction_Homo sapiens_hsa047400.86675372
50Glutamatergic synapse_Homo sapiens_hsa047240.84942019
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84512063
52Taste transduction_Homo sapiens_hsa047420.84265400
53Systemic lupus erythematosus_Homo sapiens_hsa053220.79438912
54Tryptophan metabolism_Homo sapiens_hsa003800.78593628
55Basal transcription factors_Homo sapiens_hsa030220.78419930
56Peroxisome_Homo sapiens_hsa041460.76915306
57Regulation of autophagy_Homo sapiens_hsa041400.75390535
58Hematopoietic cell lineage_Homo sapiens_hsa046400.74527935
59Ribosome_Homo sapiens_hsa030100.68169974
60Spliceosome_Homo sapiens_hsa030400.67295889
61Purine metabolism_Homo sapiens_hsa002300.66387865
62Ether lipid metabolism_Homo sapiens_hsa005650.65773934
63Circadian rhythm_Homo sapiens_hsa047100.64784763
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63224488
65Vibrio cholerae infection_Homo sapiens_hsa051100.62123496
66Chemical carcinogenesis_Homo sapiens_hsa052040.61337487
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59971971
68Cocaine addiction_Homo sapiens_hsa050300.59871386
69Cholinergic synapse_Homo sapiens_hsa047250.58088373
70Amphetamine addiction_Homo sapiens_hsa050310.55595292
71One carbon pool by folate_Homo sapiens_hsa006700.54877439
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54363366
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51367462
74Gastric acid secretion_Homo sapiens_hsa049710.50022506
75Oxytocin signaling pathway_Homo sapiens_hsa049210.47389202
76Epstein-Barr virus infection_Homo sapiens_hsa051690.46417090
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46151746
78Pyrimidine metabolism_Homo sapiens_hsa002400.46074689
79Sulfur relay system_Homo sapiens_hsa041220.45462057
80Alcoholism_Homo sapiens_hsa050340.43430064
81Butanoate metabolism_Homo sapiens_hsa006500.41496809
82Arginine biosynthesis_Homo sapiens_hsa002200.37258250
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36721655
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36178103
85Ovarian steroidogenesis_Homo sapiens_hsa049130.35217463
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.34979638
87Long-term depression_Homo sapiens_hsa047300.34372282
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.33922665
89Renin secretion_Homo sapiens_hsa049240.33742245
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33396987
91Arachidonic acid metabolism_Homo sapiens_hsa005900.33376276
92T cell receptor signaling pathway_Homo sapiens_hsa046600.32455304
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32365915
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32120264
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31806159
96RNA transport_Homo sapiens_hsa030130.31250343
97Retinol metabolism_Homo sapiens_hsa008300.30166106
98ABC transporters_Homo sapiens_hsa020100.29709760
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.28740450
100Oocyte meiosis_Homo sapiens_hsa041140.28613135

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »