UBBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GDP-mannose metabolic process (GO:0019673)9.70429041
2mannose metabolic process (GO:0006013)9.04262623
3chaperone-mediated protein transport (GO:0072321)8.86386758
4DNA deamination (GO:0045006)7.67151994
5nucleoside transmembrane transport (GO:1901642)7.32930872
6nucleoside transport (GO:0015858)6.04967438
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.56875437
8ATP synthesis coupled proton transport (GO:0015986)5.56875437
9interferon-gamma production (GO:0032609)5.38841845
10cytidine metabolic process (GO:0046087)5.32159025
11cytidine catabolic process (GO:0006216)5.32159025
12cytidine deamination (GO:0009972)5.32159025
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.78053540
14behavioral response to nicotine (GO:0035095)4.72913871
15exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.52991891
16nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.33628397
17positive regulation of defense response to virus by host (GO:0002230)4.32183622
18pyrimidine ribonucleoside catabolic process (GO:0046133)4.31383170
19regulation of immunoglobulin secretion (GO:0051023)4.23699269
20outer ear morphogenesis (GO:0042473)4.01163719
21endoderm formation (GO:0001706)3.90145755
22cofactor transport (GO:0051181)3.81082084
23response to pheromone (GO:0019236)3.80916675
24modified amino acid transport (GO:0072337)3.80082759
25tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.74679944
26RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.74679944
27viral transcription (GO:0019083)3.63801741
28reproduction (GO:0000003)3.61853649
29translational elongation (GO:0006414)3.53083371
30nucleotide-sugar biosynthetic process (GO:0009226)3.52379858
31translational termination (GO:0006415)3.49141655
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.48969565
33sulfur compound transport (GO:0072348)3.47392554
34ribosomal small subunit assembly (GO:0000028)3.46185686
35negative regulation of cAMP-mediated signaling (GO:0043951)3.45992220
36positive regulation of fatty acid transport (GO:2000193)3.44083882
37ribosomal small subunit biogenesis (GO:0042274)3.38911927
38peroxisome fission (GO:0016559)3.34350329
39chaperone mediated protein folding requiring cofactor (GO:0051085)3.32369077
40SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.24370072
41ATP biosynthetic process (GO:0006754)3.23567691
42positive regulation of icosanoid secretion (GO:0032305)3.22505335
43cotranslational protein targeting to membrane (GO:0006613)3.22430808
44amine catabolic process (GO:0009310)3.16040885
45cellular biogenic amine catabolic process (GO:0042402)3.16040885
46positive regulation of fatty acid oxidation (GO:0046321)3.15761074
47protein targeting to ER (GO:0045047)3.15642322
48positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.15530403
49regulation of mitochondrial membrane potential (GO:0051881)3.12905886
50regulation of isotype switching to IgG isotypes (GO:0048302)3.09734429
51cellular response to interleukin-15 (GO:0071350)3.08858337
52intracellular protein transmembrane import (GO:0044743)3.07499209
53purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.07162556
54viral protein processing (GO:0019082)3.05201296
55somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.03803708
56isotype switching (GO:0045190)3.03803708
57somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.03803708
58purine nucleoside triphosphate biosynthetic process (GO:0009145)3.03265073
59establishment of protein localization to endoplasmic reticulum (GO:0072599)3.02894911
60cellular response to estradiol stimulus (GO:0071392)3.02317035
61protein localization to endoplasmic reticulum (GO:0070972)3.00628795
62pantothenate metabolic process (GO:0015939)2.99789412
63electron transport chain (GO:0022900)2.98444985
64translation (GO:0006412)2.98113403
65respiratory electron transport chain (GO:0022904)2.96443295
66coenzyme A biosynthetic process (GO:0015937)2.96233164
67monocyte chemotaxis (GO:0002548)2.95653175
68hydrogen ion transmembrane transport (GO:1902600)2.95489183
69carbohydrate derivative transport (GO:1901264)2.94788239
70positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.94326432
71histone H2A acetylation (GO:0043968)2.86574082
72proton transport (GO:0015992)2.84752072
73hydrogen transport (GO:0006818)2.78116459
74regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.76797139
75regulation of chronic inflammatory response (GO:0002676)2.75012816
76short-chain fatty acid metabolic process (GO:0046459)2.72743242
77dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.72353825
78mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.70149736
79deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.66984864
80cobalamin metabolic process (GO:0009235)2.64422600
81indolalkylamine metabolic process (GO:0006586)2.63094306
82positive regulation of fatty acid beta-oxidation (GO:0032000)2.62932563
83viral life cycle (GO:0019058)2.61851347
84negative regulation of B cell apoptotic process (GO:0002903)2.60866996
85cellular protein complex disassembly (GO:0043624)2.60643425
86water-soluble vitamin biosynthetic process (GO:0042364)2.58379131
87purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.55502130
88GTP biosynthetic process (GO:0006183)2.55212961
89indole-containing compound catabolic process (GO:0042436)2.51927595
90indolalkylamine catabolic process (GO:0046218)2.51927595
91tryptophan catabolic process (GO:0006569)2.51927595
92establishment of protein localization to mitochondrial membrane (GO:0090151)2.51426794
93urinary tract smooth muscle contraction (GO:0014848)2.50676582
94negative regulation by host of viral transcription (GO:0043922)2.50503937
95ribonucleoside triphosphate biosynthetic process (GO:0009201)2.50076937
96regulation of defense response to virus by host (GO:0050691)2.49320371
97positive regulation of myoblast differentiation (GO:0045663)2.47937167
98regulation of receptor binding (GO:1900120)2.47667583
99otic vesicle formation (GO:0030916)2.46031933
100establishment of protein localization to peroxisome (GO:0072663)2.45342956

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse7.13392184
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.04084992
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.94394754
4EZH2_22144423_ChIP-Seq_EOC_Human3.04719837
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.85665949
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30616228
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.24345901
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19435570
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14621637
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.12794272
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.11519729
12ZNF274_21170338_ChIP-Seq_K562_Hela2.10235039
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.08355093
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.08150672
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.05360393
16VDR_22108803_ChIP-Seq_LS180_Human2.05279753
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.02099721
18ETS1_20019798_ChIP-Seq_JURKAT_Human1.90158151
19SRY_22984422_ChIP-ChIP_TESTIS_Rat1.67185184
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.66505357
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66487672
22IGF1R_20145208_ChIP-Seq_DFB_Human1.65831664
23GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.58213429
24PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.55756035
25RUNX_20019798_ChIP-Seq_JUKART_Human1.54411386
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51029560
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49802161
28ELK1_19687146_ChIP-ChIP_HELA_Human1.45136250
29HTT_18923047_ChIP-ChIP_STHdh_Human1.41009655
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.40690754
31VDR_23849224_ChIP-Seq_CD4+_Human1.39950334
32EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.33790930
33GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33332313
34NANOG_20526341_ChIP-Seq_ESCs_Human1.32382294
35CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.31357029
36TP53_22573176_ChIP-Seq_HFKS_Human1.28121625
37GATA6_21074721_ChIP-Seq_CACO-2_Human1.28085508
38PHF8_20622853_ChIP-Seq_HELA_Human1.26344757
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25266398
40TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.24298504
41TAF15_26573619_Chip-Seq_HEK293_Human1.24005189
42GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.22960361
43ETV1_20927104_ChIP-Seq_GIST48_Human1.21477297
44BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.21422167
45MYC_19829295_ChIP-Seq_ESCs_Human1.19764973
46RBPJ_21746931_ChIP-Seq_IB4_Human1.19483327
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.19148383
48CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.19070568
49MYC_18940864_ChIP-ChIP_HL60_Human1.17834303
50EWS_26573619_Chip-Seq_HEK293_Human1.17675799
51AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16339071
52TAF2_19829295_ChIP-Seq_ESCs_Human1.15981767
53ELK1_22589737_ChIP-Seq_MCF10A_Human1.15231368
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15084386
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13602172
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.12490083
57NCOR_22424771_ChIP-Seq_293T_Human1.12062202
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11671497
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11660212
60RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.10855846
61GATA3_26560356_Chip-Seq_TH2_Human1.08889200
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08368553
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07531433
64NFYB_21822215_ChIP-Seq_K562_Human1.07431843
65PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06482472
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.06353530
67NFYA_21822215_ChIP-Seq_K562_Human1.05936787
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.05517427
69PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.04634690
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03725389
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.03725389
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.03454205
73FOXH1_21741376_ChIP-Seq_EPCs_Human1.02725623
74HOXB7_26014856_ChIP-Seq_BT474_Human1.02294823
75P53_21459846_ChIP-Seq_SAOS-2_Human1.02098814
76HNFA_21074721_ChIP-Seq_CACO-2_Human1.01875482
77FOXP3_21729870_ChIP-Seq_TREG_Human0.98461281
78CBX2_22325352_ChIP-Seq_293T-Rex_Human0.98039028
79STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97947259
80SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97537011
81EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96833565
82CREB1_15753290_ChIP-ChIP_HEK293T_Human0.96825912
83RNF2_27304074_Chip-Seq_NSC_Mouse0.96655202
84ERA_21632823_ChIP-Seq_H3396_Human0.96317877
85E2F1_20622854_ChIP-Seq_HELA_Human0.96301462
86CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95943357
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95174382
88BCAT_22108803_ChIP-Seq_LS180_Human0.94985491
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93294805
90IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.93261089
91PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93261024
92CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.93098845
93ERG_20517297_ChIP-Seq_VCAP_Human0.92355896
94TBL1_22424771_ChIP-Seq_293T_Human0.90746731
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90674891
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90492060
97YY1_22570637_ChIP-Seq_MALME-3M_Human0.90049545
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89167981
99BCL6_27268052_Chip-Seq_Bcells_Human0.88879432
100EZH2_27294783_Chip-Seq_ESCs_Mouse0.88876863

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex5.64678870
2MP0005671_abnormal_response_to4.03357414
3MP0005360_urolithiasis3.86121980
4MP0006072_abnormal_retinal_apoptosis3.44451298
5MP0003646_muscle_fatigue3.35189698
6MP0004043_abnormal_pH_regulation3.20967091
7MP0009379_abnormal_foot_pigmentation3.05935164
8MP0004145_abnormal_muscle_electrophysio2.38698724
9MP0001873_stomach_inflammation2.34973469
10MP0005387_immune_system_phenotype2.27453237
11MP0001790_abnormal_immune_system2.27453237
12MP0002837_dystrophic_cardiac_calcinosis2.14555990
13MP0003011_delayed_dark_adaptation2.14060017
14MP0001835_abnormal_antigen_presentation2.07794706
15MP0008875_abnormal_xenobiotic_pharmacok2.05357020
16MP0002102_abnormal_ear_morphology1.97246198
17MP0008872_abnormal_physiological_respon1.81492191
18MP0000685_abnormal_immune_system1.74551679
19MP0001968_abnormal_touch/_nociception1.67885353
20MP0006292_abnormal_olfactory_placode1.65985831
21MP0005645_abnormal_hypothalamus_physiol1.65436088
22MP0003195_calcinosis1.62820592
23MP0001485_abnormal_pinna_reflex1.61758439
24MP0006082_CNS_inflammation1.59842450
25MP0000372_irregular_coat_pigmentation1.51454096
26MP0008260_abnormal_autophagy1.50721863
27MP0001905_abnormal_dopamine_level1.47070127
28MP0001727_abnormal_embryo_implantation1.46901868
29MP0009333_abnormal_splenocyte_physiolog1.45759662
30MP0001986_abnormal_taste_sensitivity1.45160759
31MP0000604_amyloidosis1.43592924
32MP0004142_abnormal_muscle_tone1.43151642
33MP0008877_abnormal_DNA_methylation1.40806384
34MP0002148_abnormal_hypersensitivity_rea1.40763007
35MP0005253_abnormal_eye_physiology1.35875998
36MP0002138_abnormal_hepatobiliary_system1.32659626
37MP0002163_abnormal_gland_morphology1.32526528
38MP0001853_heart_inflammation1.31886887
39MP0003283_abnormal_digestive_organ1.30777382
40MP0005551_abnormal_eye_electrophysiolog1.23981714
41MP0002653_abnormal_ependyma_morphology1.20226393
42MP0005379_endocrine/exocrine_gland_phen1.18608391
43MP0004885_abnormal_endolymph1.17462361
44MP0001529_abnormal_vocalization1.17342967
45MP0003329_amyloid_beta_deposits1.16878441
46MP0009785_altered_susceptibility_to1.12679863
47MP0005389_reproductive_system_phenotype1.11749450
48MP0002733_abnormal_thermal_nociception1.11304126
49MP0005377_hearing/vestibular/ear_phenot1.10283316
50MP0003878_abnormal_ear_physiology1.10283316
51MP0002160_abnormal_reproductive_system1.07196419
52MP0006276_abnormal_autonomic_nervous1.07086909
53MP0001800_abnormal_humoral_immune1.06410988
54MP0005000_abnormal_immune_tolerance1.06024170
55MP0002272_abnormal_nervous_system1.05421970
56MP0005084_abnormal_gallbladder_morpholo1.05336488
57MP0004742_abnormal_vestibular_system1.04131661
58MP0002095_abnormal_skin_pigmentation1.00508331
59MP0009745_abnormal_behavioral_response0.99085390
60MP0004133_heterotaxia0.98008136
61MP0003567_abnormal_fetal_cardiomyocyte0.97631811
62MP0002736_abnormal_nociception_after0.97609965
63MP0001542_abnormal_bone_strength0.97236065
64MP0002723_abnormal_immune_serum0.96390445
65MP0000049_abnormal_middle_ear0.95252959
66MP0009764_decreased_sensitivity_to0.93280095
67MP0005025_abnormal_response_to0.92537476
68MP0005195_abnormal_posterior_eye0.90742907
69MP0001970_abnormal_pain_threshold0.87176729
70MP0010386_abnormal_urinary_bladder0.86829787
71MP0005083_abnormal_biliary_tract0.83931672
72MP0005174_abnormal_tail_pigmentation0.80993557
73MP0008775_abnormal_heart_ventricle0.80966556
74MP0000778_abnormal_nervous_system0.78936019
75MP0002557_abnormal_social/conspecific_i0.75953558
76MP0002572_abnormal_emotion/affect_behav0.75130729
77MP0002277_abnormal_respiratory_mucosa0.72228855
78MP0002420_abnormal_adaptive_immunity0.71601044
79MP0002933_joint_inflammation0.71521069
80MP0010155_abnormal_intestine_physiology0.71479316
81MP0002735_abnormal_chemical_nociception0.71101708
82MP0005464_abnormal_platelet_physiology0.70707830
83MP0003122_maternal_imprinting0.70361939
84MP0005220_abnormal_exocrine_pancreas0.69321498
85MP0008007_abnormal_cellular_replicative0.68594222
86MP0005448_abnormal_energy_balance0.67863151
87MP0009250_abnormal_appendicular_skeleto0.67490087
88MP0001819_abnormal_immune_cell0.67054694
89MP0003787_abnormal_imprinting0.65472205
90MP0002210_abnormal_sex_determination0.65338308
91MP0000538_abnormal_urinary_bladder0.65303689
92MP0001845_abnormal_inflammatory_respons0.63713280
93MP0002234_abnormal_pharynx_morphology0.63593485
94MP0002693_abnormal_pancreas_physiology0.63222197
95MP0005085_abnormal_gallbladder_physiolo0.63025894
96MP0001919_abnormal_reproductive_system0.62609853
97MP0006036_abnormal_mitochondrial_physio0.62085381
98MP0000689_abnormal_spleen_morphology0.62039825
99MP0002752_abnormal_somatic_nervous0.61659661
100MP0005332_abnormal_amino_acid0.60536169

Predicted human phenotypes

RankGene SetZ-score
1Global brain atrophy (HP:0002283)5.84557218
2Hypobetalipoproteinemia (HP:0003563)4.76061682
3Methylmalonic acidemia (HP:0002912)4.32696650
4Congenital stationary night blindness (HP:0007642)4.18673078
5Akinesia (HP:0002304)4.11892926
6Methylmalonic aciduria (HP:0012120)3.88094516
7Stomatitis (HP:0010280)3.85815917
8Elevated erythrocyte sedimentation rate (HP:0003565)3.79760222
9Neurodegeneration (HP:0002180)3.74645453
10Acanthocytosis (HP:0001927)3.53835876
11Abnormality of midbrain morphology (HP:0002418)3.40579543
12Molar tooth sign on MRI (HP:0002419)3.40579543
13Hyperglycinemia (HP:0002154)3.39794615
14Increased CSF lactate (HP:0002490)3.36936154
15Abnormality of the phalanges of the 2nd finger (HP:0009541)3.27441849
16Patent foramen ovale (HP:0001655)3.21910508
17Hepatocellular necrosis (HP:0001404)3.14637114
18Hepatic necrosis (HP:0002605)3.14000779
19Mitochondrial inheritance (HP:0001427)3.09917045
20IgG deficiency (HP:0004315)3.09185254
21Dysphonia (HP:0001618)3.08797350
22Tongue fasciculations (HP:0001308)3.08195557
23Microretrognathia (HP:0000308)3.08172750
24Delayed CNS myelination (HP:0002188)3.07678380
25Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.06351318
26Abnormality of alanine metabolism (HP:0010916)3.06351318
27Hyperalaninemia (HP:0003348)3.06351318
28Diminished movement (HP:0002374)2.99279209
29Decreased muscle mass (HP:0003199)2.96835534
30Agitation (HP:0000713)2.92276836
31Dyskinesia (HP:0100660)2.88310494
32Hypoplasia of the pons (HP:0012110)2.72944461
33Increased IgM level (HP:0003496)2.71330283
34Muscle fibrillation (HP:0010546)2.61342449
35Abnormality of vitamin B metabolism (HP:0004340)2.61037300
36Increased hepatocellular lipid droplets (HP:0006565)2.56170934
37Acute necrotizing encephalopathy (HP:0006965)2.54166743
38Parakeratosis (HP:0001036)2.52466106
39Agammaglobulinemia (HP:0004432)2.51935534
40Congenital, generalized hypertrichosis (HP:0004540)2.48386400
41CNS demyelination (HP:0007305)2.47903779
42Abnormality of the vitamin B12 metabolism (HP:0004341)2.47284596
43Craniofacial dystonia (HP:0012179)2.44207789
44Partial duplication of the phalanx of hand (HP:0009999)2.39807524
45Morphological abnormality of the pyramidal tract (HP:0002062)2.38827879
46Abnormality of the pons (HP:0007361)2.38633355
47Tubulointerstitial nephritis (HP:0001970)2.30672114
48Focal dystonia (HP:0004373)2.30587971
49Ketoacidosis (HP:0001993)2.27127242
50Stenosis of the external auditory canal (HP:0000402)2.27004040
51Abnormality of the basal ganglia (HP:0002134)2.26933436
52Lipid accumulation in hepatocytes (HP:0006561)2.24979167
53Nephronophthisis (HP:0000090)2.24490441
54Hypolipoproteinemia (HP:0010981)2.22184463
55T lymphocytopenia (HP:0005403)2.21130120
56Increased serum lactate (HP:0002151)2.19473173
57Medial flaring of the eyebrow (HP:0010747)2.18970911
58Pancreatic cysts (HP:0001737)2.18714483
59Severe muscular hypotonia (HP:0006829)2.18503449
60Hemiplegia (HP:0002301)2.17944711
61Clumsiness (HP:0002312)2.11216630
62Brushfield spots (HP:0001088)2.10297086
63Large eyes (HP:0001090)2.09607433
64Abnormality of cells of the erythroid lineage (HP:0012130)2.09386562
65Ketosis (HP:0001946)2.08912117
66Abnormal mitochondria in muscle tissue (HP:0008316)2.06817095
67Abnormality of T cells (HP:0002843)2.04700778
68Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.01228545
69True hermaphroditism (HP:0010459)1.98770147
70Renal cortical cysts (HP:0000803)1.98625618
71Progressive macrocephaly (HP:0004481)1.97766558
72Renal Fanconi syndrome (HP:0001994)1.97490335
73Abnormal rod and cone electroretinograms (HP:0008323)1.96168333
74Type 2 muscle fiber atrophy (HP:0003554)1.96140154
75Absent rod-and cone-mediated responses on ERG (HP:0007688)1.96117853
76Abnormality of T cell number (HP:0011839)1.93916927
77Abnormality of serum amino acid levels (HP:0003112)1.92236252
78Hypoalbuminemia (HP:0003073)1.91793907
79Abnormal albumin level (HP:0012116)1.91793907
80Pendular nystagmus (HP:0012043)1.91193538
81Recurrent bronchitis (HP:0002837)1.90918545
82Restlessness (HP:0000711)1.89579777
83Keratoconus (HP:0000563)1.86337643
84Increased corneal curvature (HP:0100692)1.86337643
85Abnormality of dicarboxylic acid metabolism (HP:0010995)1.85978254
86Dicarboxylic aciduria (HP:0003215)1.85978254
87Abnormality of the phalanges of the hallux (HP:0010057)1.85195269
88Generalized aminoaciduria (HP:0002909)1.82957089
89Renal tubular dysfunction (HP:0000124)1.82349472
90Broad distal phalanx of finger (HP:0009836)1.82044574
91Acute encephalopathy (HP:0006846)1.81848820
92Hypoproteinemia (HP:0003075)1.80575326
93Glycosuria (HP:0003076)1.79336467
94Abnormality of urine glucose concentration (HP:0011016)1.79336467
95Severe combined immunodeficiency (HP:0004430)1.75911234
96Respiratory difficulties (HP:0002880)1.75863246
97Amblyopia (HP:0000646)1.73218520
98Hypomagnesemia (HP:0002917)1.72297102
99Poor suck (HP:0002033)1.70258363
100Abnormality of the 2nd finger (HP:0004100)1.69740231

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK25.03699798
2PDK24.81118204
3GRK13.56819988
4BCKDK3.15196048
5ADRBK23.07386233
6TXK3.03155732
7ERN12.37164819
8ZAK1.98047149
9MST41.97176128
10TLK11.95743653
11MAP2K61.84083361
12PHKG21.69675213
13PHKG11.69675213
14MAP4K21.68367108
15LIMK11.67167856
16BMPR1B1.62658697
17WNK31.53281123
18TAOK31.45896165
19CDK81.38328791
20TGFBR11.37104412
21FRK1.30543981
22OBSCN1.29908351
23MAP3K121.24683175
24PASK1.22935970
25DYRK21.22109413
26WNK41.16605117
27DAPK21.16602529
28KDR1.13956648
29NME11.12228490
30TESK11.12135945
31INSRR1.09557380
32ITK1.07730130
33LCK1.05560469
34GRK71.05403225
35VRK11.04774159
36FES1.02982342
37VRK21.01087958
38EPHB21.00720076
39SYK1.00212167
40MAPKAPK30.97281277
41MAP2K70.97036003
42BUB10.93567551
43ADRBK10.91823143
44DAPK10.91002163
45PINK10.89214117
46PKN10.88248855
47TBK10.87086316
48PRKCQ0.84499012
49AKT20.81080325
50MAPK130.79923580
51PRKCG0.79497157
52TIE10.73290793
53TEC0.72216906
54PRKCI0.70541277
55ABL20.67641661
56DYRK1B0.66063229
57PRKACA0.65181480
58IKBKB0.63438548
59STK380.62955784
60MAPK70.60133507
61MAP2K20.59832620
62PRKCE0.59775591
63PRKD20.59508437
64CAMK2A0.58953380
65AURKA0.57884652
66CCNB10.57307991
67IKBKE0.56417558
68PRKCH0.54631430
69PIK3CA0.54332991
70MUSK0.53338393
71PRKCA0.51530922
72NUAK10.51440423
73CSNK2A10.49161263
74DAPK30.48580232
75PAK30.44824710
76MINK10.44577182
77ROCK10.41786768
78MAP3K110.41662583
79PIK3CG0.40298359
80NTRK20.40170519
81MAP3K40.39682427
82PIM20.39421098
83TRIM280.38919643
84STK38L0.38668598
85PLK20.36842276
86GRK50.36732806
87RPS6KA50.36552923
88CSK0.36514313
89CAMK2G0.36334417
90CSNK2A20.36136576
91PRKCD0.34933471
92BTK0.33675543
93EIF2AK30.31301370
94ATR0.30913130
95INSR0.30470361
96PRKD30.29520053
97PIM10.29516496
98RPS6KA10.29225207
99NME20.29055640
100PRKG10.28095574

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.19306487
2Oxidative phosphorylation_Homo sapiens_hsa001903.43533678
3Primary immunodeficiency_Homo sapiens_hsa053403.09568864
4Allograft rejection_Homo sapiens_hsa053302.98178707
5Parkinsons disease_Homo sapiens_hsa050122.97393977
6Autoimmune thyroid disease_Homo sapiens_hsa053202.95306438
7Asthma_Homo sapiens_hsa053102.92184255
8Proteasome_Homo sapiens_hsa030502.87302098
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.35199909
10Cardiac muscle contraction_Homo sapiens_hsa042602.19824388
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.17364470
12Alzheimers disease_Homo sapiens_hsa050102.09904981
13Linoleic acid metabolism_Homo sapiens_hsa005912.06951660
14Graft-versus-host disease_Homo sapiens_hsa053321.93687373
15Sulfur metabolism_Homo sapiens_hsa009201.89190606
16Regulation of autophagy_Homo sapiens_hsa041401.85639905
17Type I diabetes mellitus_Homo sapiens_hsa049401.80049931
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.79463664
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.74131927
20Huntingtons disease_Homo sapiens_hsa050161.71432898
21Protein export_Homo sapiens_hsa030601.71217298
22RNA degradation_Homo sapiens_hsa030181.67509314
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65511726
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55548054
25Fructose and mannose metabolism_Homo sapiens_hsa000511.50661932
26Vitamin B6 metabolism_Homo sapiens_hsa007501.47183058
27Caffeine metabolism_Homo sapiens_hsa002321.45842291
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41597913
29Phototransduction_Homo sapiens_hsa047441.39991751
30Antigen processing and presentation_Homo sapiens_hsa046121.38788841
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.33889581
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.29785135
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29140651
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.26754251
35Tryptophan metabolism_Homo sapiens_hsa003801.21673934
36Peroxisome_Homo sapiens_hsa041461.20668113
37Hematopoietic cell lineage_Homo sapiens_hsa046401.17942998
38RNA polymerase_Homo sapiens_hsa030201.16917098
39Propanoate metabolism_Homo sapiens_hsa006401.12859828
40Folate biosynthesis_Homo sapiens_hsa007901.11616099
41Rheumatoid arthritis_Homo sapiens_hsa053231.09155473
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05191549
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03510485
44T cell receptor signaling pathway_Homo sapiens_hsa046600.98811569
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94247266
46Arachidonic acid metabolism_Homo sapiens_hsa005900.93107148
47Ether lipid metabolism_Homo sapiens_hsa005650.87810186
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81877409
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80918899
50Nitrogen metabolism_Homo sapiens_hsa009100.79639260
51Taste transduction_Homo sapiens_hsa047420.79137399
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.78891653
53Viral myocarditis_Homo sapiens_hsa054160.72747226
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72358759
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70909912
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67135842
57Butanoate metabolism_Homo sapiens_hsa006500.65739526
58Olfactory transduction_Homo sapiens_hsa047400.65605833
59Insulin secretion_Homo sapiens_hsa049110.64267497
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64056196
61Homologous recombination_Homo sapiens_hsa034400.62640513
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60420206
63Selenocompound metabolism_Homo sapiens_hsa004500.59958651
64Chemical carcinogenesis_Homo sapiens_hsa052040.58855951
65Basal transcription factors_Homo sapiens_hsa030220.55739884
66Fat digestion and absorption_Homo sapiens_hsa049750.55694195
67Retinol metabolism_Homo sapiens_hsa008300.55406364
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53893717
69Metabolic pathways_Homo sapiens_hsa011000.53159202
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51637884
71Pyrimidine metabolism_Homo sapiens_hsa002400.51439515
72Steroid biosynthesis_Homo sapiens_hsa001000.51335821
73Ovarian steroidogenesis_Homo sapiens_hsa049130.50586567
74Purine metabolism_Homo sapiens_hsa002300.50060757
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47517563
76Systemic lupus erythematosus_Homo sapiens_hsa053220.46583792
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45611992
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43796571
79Serotonergic synapse_Homo sapiens_hsa047260.43656109
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43629502
81Salivary secretion_Homo sapiens_hsa049700.41742960
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39857071
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36444261
84Nicotine addiction_Homo sapiens_hsa050330.35427786
85Collecting duct acid secretion_Homo sapiens_hsa049660.31986056
86GABAergic synapse_Homo sapiens_hsa047270.31032990
87Malaria_Homo sapiens_hsa051440.30077322
88Morphine addiction_Homo sapiens_hsa050320.30036832
89Starch and sucrose metabolism_Homo sapiens_hsa005000.28067638
90PPAR signaling pathway_Homo sapiens_hsa033200.26581881
91Mineral absorption_Homo sapiens_hsa049780.26342921
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.26234267
93Fanconi anemia pathway_Homo sapiens_hsa034600.25321296
94One carbon pool by folate_Homo sapiens_hsa006700.22098957
95Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.19009727
96Mismatch repair_Homo sapiens_hsa034300.18282427
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.17821094
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.16253372
99Measles_Homo sapiens_hsa051620.14598687
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.13321820

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