ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.07479287
2	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.07479287
3	adenosine metabolic process (GO:0046085)	4.98436559
4	epithelial cell fate commitment (GO:0072148)	4.90310184
5	positive regulation of histone H3-K4 methylation (GO:0051571)	4.70544996
6	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.64835385
7	response to folic acid (GO:0051593)	4.56130832
8	positive regulation of oligodendrocyte differentiation (GO:0048714)	4.49092207
9	regulation of cell maturation (GO:1903429)	4.49074294
10	histone-serine phosphorylation (GO:0035404)	4.47052580
11	positive regulation of endothelial cell differentiation (GO:0045603)	4.38813141
12	histone H2B ubiquitination (GO:0033523)	4.24920639
13	deoxyribose phosphate biosynthetic process (GO:0046385)	4.22908628
14	2-deoxyribonucleotide biosynthetic process (GO:0009265)	4.22908628
15	interleukin-6-mediated signaling pathway (GO:0070102)	4.20963167
16	response to gravity (GO:0009629)	4.18502209
17	regulation of acrosome reaction (GO:0060046)	4.01287929
18	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.93616885
19	astrocyte differentiation (GO:0048708)	3.91261434
20	nucleoside transmembrane transport (GO:1901642)	3.89516615
21	purine nucleotide salvage (GO:0032261)	3.87063038
22	homocysteine metabolic process (GO:0050667)	3.83893113
23	pteridine-containing compound biosynthetic process (GO:0042559)	3.82060362
24	neuron fate determination (GO:0048664)	3.81795110
25	histone H3-K4 trimethylation (GO:0080182)	3.79399162
26	regulation of plasminogen activation (GO:0010755)	3.79301577
27	galactose catabolic process (GO:0019388)	3.75968370
28	folic acid-containing compound biosynthetic process (GO:0009396)	3.73802503
29	primary amino compound metabolic process (GO:1901160)	3.73692017
30	single strand break repair (GO:0000012)	3.69715048
31	protein complex biogenesis (GO:0070271)	3.68963877
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.68291053
33	NADH dehydrogenase complex assembly (GO:0010257)	3.68291053
34	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.68291053
35	cellular response to ATP (GO:0071318)	3.68039670
36	inner ear receptor cell development (GO:0060119)	3.67482522
37	platelet dense granule organization (GO:0060155)	3.56820304
38	cellular ketone body metabolic process (GO:0046950)	3.52026856
39	respiratory chain complex IV assembly (GO:0008535)	3.50714585
40	rRNA methylation (GO:0031167)	3.49633524
41	sulfur amino acid catabolic process (GO:0000098)	3.48115622
42	rRNA modification (GO:0000154)	3.47570527
43	maturation of SSU-rRNA (GO:0030490)	3.43905992
44	protein neddylation (GO:0045116)	3.42227523
45	acrosome reaction (GO:0007340)	3.35760574
46	water-soluble vitamin biosynthetic process (GO:0042364)	3.33082230
47	alternative mRNA splicing, via spliceosome (GO:0000380)	3.30650232
48	response to vitamin A (GO:0033189)	3.29793225
49	tetrahydrofolate metabolic process (GO:0046653)	3.28267068
50	adult feeding behavior (GO:0008343)	3.25255572
51	regulation of endothelial cell differentiation (GO:0045601)	3.24180700
52	galactose metabolic process (GO:0006012)	3.22487300
53	chaperone-mediated protein transport (GO:0072321)	3.21398097
54	mitochondrial respiratory chain complex assembly (GO:0033108)	3.20234564
55	cell fate commitment involved in formation of primary germ layer (GO:0060795)	3.17567034
56	GTP biosynthetic process (GO:0006183)	3.16409540
57	skeletal muscle tissue regeneration (GO:0043403)	3.15615673
58	xenobiotic catabolic process (GO:0042178)	3.13442978
59	endosome to melanosome transport (GO:0035646)	3.11360758
60	endosome to pigment granule transport (GO:0043485)	3.11360758
61	protein localization to microtubule cytoskeleton (GO:0072698)	3.09195869
62	ketone body metabolic process (GO:1902224)	3.06883293
63	C-terminal protein lipidation (GO:0006501)	3.05997221
64	protein K6-linked ubiquitination (GO:0085020)	3.05626492
65	regulation of spindle organization (GO:0090224)	3.03731346
66	neuron fate specification (GO:0048665)	3.03720462
67	cytochrome complex assembly (GO:0017004)	3.03117457
68	DNA deamination (GO:0045006)	2.97837120
69	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.97327124
70	microtubule nucleation (GO:0007020)	2.97096462
71	deoxyribonucleotide biosynthetic process (GO:0009263)	2.93874189
72	regulation of oligodendrocyte differentiation (GO:0048713)	2.93858533
73	spinal cord motor neuron differentiation (GO:0021522)	2.92336558
74	type B pancreatic cell development (GO:0003323)	2.88625909
75	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	2.88274419
76	guanosine-containing compound biosynthetic process (GO:1901070)	2.87793003
77	negative regulation of acute inflammatory response (GO:0002674)	2.87205634
78	regulation of gonadotropin secretion (GO:0032276)	2.86095375
79	desmosome organization (GO:0002934)	2.85323610
80	cullin deneddylation (GO:0010388)	2.85041057
81	intestinal epithelial cell development (GO:0060576)	2.84230176
82	regulation of type B pancreatic cell apoptotic process (GO:2000674)	2.83727161
83	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.77517272
84	detection of light stimulus involved in visual perception (GO:0050908)	2.77364744
85	detection of light stimulus involved in sensory perception (GO:0050962)	2.77364744
86	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.74885550
87	pteridine-containing compound metabolic process (GO:0042558)	2.74321478
88	C-terminal protein amino acid modification (GO:0018410)	2.72759761
89	protein-cofactor linkage (GO:0018065)	2.66849160
90	protein deneddylation (GO:0000338)	2.66176136
91	regulation of cellular amino acid metabolic process (GO:0006521)	2.65955514
92	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.64765871
93	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.64752088
94	neuromuscular process controlling posture (GO:0050884)	2.64092860
95	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.63956195
96	ATP hydrolysis coupled proton transport (GO:0015991)	2.63956195
97	kinetochore assembly (GO:0051382)	2.63590575
98	folic acid-containing compound metabolic process (GO:0006760)	2.61845253
99	regulation of podosome assembly (GO:0071801)	2.61361094
100	preassembly of GPI anchor in ER membrane (GO:0016254)	2.61138443

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.92623088
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.10306971
3	VDR_22108803_ChIP-Seq_LS180_Human	5.26827692
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.09890026
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.78331399
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.74983292
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.98218884
8	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.52285366
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.38415657
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.09233252
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.07188253
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.04119520
13	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.02681530
14	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.87402869
15	TP53_22573176_ChIP-Seq_HFKS_Human	1.83314352
16	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.73665386
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.71611380
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.59504826
19	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.56662832
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.55002095
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.54924098
22	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.43175675
23	TAF2_19829295_ChIP-Seq_ESCs_Human	1.39579727
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.37860243
25	EWS_26573619_Chip-Seq_HEK293_Human	1.36555452
26	ERG_20517297_ChIP-Seq_VCAP_Human	1.35736641
27	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.32189839
28	ZNF274_21170338_ChIP-Seq_K562_Hela	1.30718175
29	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.27109300
30	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.26337898
31	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.25333478
32	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24289614
33	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24289614
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.22340695
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.21874240
36	NCOR_22424771_ChIP-Seq_293T_Human	1.21628183
37	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.20253444
38	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.16176399
39	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.13545754
40	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.13521636
41	MYC_19829295_ChIP-Seq_ESCs_Human	1.12353359
42	ELK1_19687146_ChIP-ChIP_HELA_Human	1.12241649
43	CBP_21632823_ChIP-Seq_H3396_Human	1.10688258
44	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.09770124
45	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.09069050
46	FOXP3_21729870_ChIP-Seq_TREG_Human	1.08873618
47	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.08675112
48	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.08201954
49	BCAT_22108803_ChIP-Seq_LS180_Human	1.07817504
50	EZH2_22144423_ChIP-Seq_EOC_Human	1.06415519
51	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.04480368
52	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.02300003
53	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.01308649
54	AR_20517297_ChIP-Seq_VCAP_Human	1.01274266
55	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.01169790
56	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.98903222
57	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.97988020
58	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97882763
59	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.97083595
60	P300_27268052_Chip-Seq_Bcells_Human	0.96036828
61	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.95863331
62	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.95623593
63	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.94905561
64	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.93919668
65	FUS_26573619_Chip-Seq_HEK293_Human	0.93886260
66	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.93832887
67	P300_19829295_ChIP-Seq_ESCs_Human	0.93683244
68	CDX2_22108803_ChIP-Seq_LS180_Human	0.93569084
69	NANOG_19829295_ChIP-Seq_ESCs_Human	0.93218191
70	SOX2_19829295_ChIP-Seq_ESCs_Human	0.93218191
71	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92072437
72	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.91993496
73	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.90990030
74	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.90885126
75	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.89757437
76	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.89145161
77	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.88811260
78	E2F1_20622854_ChIP-Seq_HELA_Human	0.88733593
79	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.88485638
80	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.87742271
81	GABP_19822575_ChIP-Seq_HepG2_Human	0.87546227
82	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.86714738
83	NANOG_20526341_ChIP-Seq_ESCs_Human	0.86477723
84	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.85655887
85	HOXB7_26014856_ChIP-Seq_BT474_Human	0.85424044
86	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.84833648
87	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.83941420
88	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.82949117
89	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.82570997
90	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.81795665
91	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.81612014
92	BCL6_27268052_Chip-Seq_Bcells_Human	0.81470266
93	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.81399683
94	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.80687258
95	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.80527240
96	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.79935826
97	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.79657984
98	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.79586722
99	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.78480867
100	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.77506045

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009780_abnormal_chondrocyte_physiolo	4.49427933
2	MP0005360_urolithiasis	4.06856156
3	MP0003195_calcinosis	3.63156263
4	MP0003693_abnormal_embryo_hatching	3.19018272
5	MP0005646_abnormal_pituitary_gland	3.18720967
6	MP0004885_abnormal_endolymph	3.05525585
7	MP0003045_fibrosis	2.78922633
8	MP0008057_abnormal_DNA_replication	2.47244500
9	MP0006276_abnormal_autonomic_nervous	2.43411825
10	MP0001968_abnormal_touch/_nociception	2.43350070
11	MP0002837_dystrophic_cardiac_calcinosis	2.35461501
12	MP0002736_abnormal_nociception_after	2.32000868
13	MP0003183_abnormal_peptide_metabolism	2.17670206
14	MP0006072_abnormal_retinal_apoptosis	2.14021948
15	MP0003950_abnormal_plasma_membrane	2.10319090
16	MP0003787_abnormal_imprinting	2.10055141
17	MP0008875_abnormal_xenobiotic_pharmacok	1.90557517
18	MP0004145_abnormal_muscle_electrophysio	1.83191248
19	MP0008872_abnormal_physiological_respon	1.79111978
20	MP0002735_abnormal_chemical_nociception	1.76201570
21	MP0003186_abnormal_redox_activity	1.72756474
22	MP0001905_abnormal_dopamine_level	1.65271018
23	MP0003880_abnormal_central_pattern	1.61809273
24	MP0001756_abnormal_urination	1.61566623
25	MP0002163_abnormal_gland_morphology	1.60872313
26	MP0001944_abnormal_pancreas_morphology	1.57704496
27	MP0006036_abnormal_mitochondrial_physio	1.55132858
28	MP0008877_abnormal_DNA_methylation	1.54564420
29	MP0002938_white_spotting	1.52496718
30	MP0000013_abnormal_adipose_tissue	1.47744809
31	MP0005367_renal/urinary_system_phenotyp	1.45480871
32	MP0000516_abnormal_urinary_system	1.45480871
33	MP0005551_abnormal_eye_electrophysiolog	1.44283733
34	MP0000749_muscle_degeneration	1.43124057
35	MP0005084_abnormal_gallbladder_morpholo	1.35379262
36	MP0005332_abnormal_amino_acid	1.34102613
37	MP0004147_increased_porphyrin_level	1.34099887
38	MP0002139_abnormal_hepatobiliary_system	1.33384688
39	MP0005636_abnormal_mineral_homeostasis	1.33037803
40	MP0003786_premature_aging	1.31211877
41	MP0003123_paternal_imprinting	1.28721754
42	MP0002168_other_aberrant_phenotype	1.25738334
43	MP0005253_abnormal_eye_physiology	1.24689279
44	MP0003638_abnormal_response/metabolism_	1.24385191
45	MP0005379_endocrine/exocrine_gland_phen	1.23583638
46	MP0004142_abnormal_muscle_tone	1.23360167
47	MP0000534_abnormal_ureter_morphology	1.22967021
48	MP0000750_abnormal_muscle_regeneration	1.20673634
49	MP0002733_abnormal_thermal_nociception	1.20052933
50	MP0003942_abnormal_urinary_system	1.17912040
51	MP0002160_abnormal_reproductive_system	1.15732590
52	MP0002693_abnormal_pancreas_physiology	1.15479776
53	MP0008775_abnormal_heart_ventricle	1.12581897
54	MP0004134_abnormal_chest_morphology	1.11148887
55	MP0002095_abnormal_skin_pigmentation	1.10879590
56	MP0001485_abnormal_pinna_reflex	1.10787737
57	MP0005464_abnormal_platelet_physiology	1.09973705
58	MP0008789_abnormal_olfactory_epithelium	1.09152749
59	MP0008995_early_reproductive_senescence	1.07112038
60	MP0005645_abnormal_hypothalamus_physiol	1.01643523
61	MP0001765_abnormal_ion_homeostasis	0.99867810
62	MP0002078_abnormal_glucose_homeostasis	0.97191677
63	MP0005395_other_phenotype	0.95872877
64	MP0005670_abnormal_white_adipose	0.95468931
65	MP0004019_abnormal_vitamin_homeostasis	0.94520372
66	MP0005165_increased_susceptibility_to	0.92429924
67	MP0003806_abnormal_nucleotide_metabolis	0.92320115
68	MP0002876_abnormal_thyroid_physiology	0.91302743
69	MP0009643_abnormal_urine_homeostasis	0.91148720
70	MP0009250_abnormal_appendicular_skeleto	0.88185598
71	MP0005365_abnormal_bile_salt	0.87727896
72	MP0002127_abnormal_cardiovascular_syste	0.86601367
73	MP0001970_abnormal_pain_threshold	0.86584700
74	MP0005410_abnormal_fertilization	0.84552395
75	MP0001764_abnormal_homeostasis	0.83459648
76	MP0008007_abnormal_cellular_replicative	0.82254150
77	MP0000026_abnormal_inner_ear	0.82232887
78	MP0000733_abnormal_muscle_development	0.81990592
79	MP0010094_abnormal_chromosome_stability	0.81262681
80	MP0005220_abnormal_exocrine_pancreas	0.80982606
81	MP0002184_abnormal_innervation	0.79241145
82	MP0005085_abnormal_gallbladder_physiolo	0.78393987
83	MP0001270_distended_abdomen	0.77779566
84	MP0002295_abnormal_pulmonary_circulatio	0.76284150
85	MP0005389_reproductive_system_phenotype	0.75846581
86	MP0005408_hypopigmentation	0.75465624
87	MP0001919_abnormal_reproductive_system	0.74954276
88	MP0003122_maternal_imprinting	0.74753568
89	MP0004036_abnormal_muscle_relaxation	0.73768258
90	MP0009745_abnormal_behavioral_response	0.73217004
91	MP0001986_abnormal_taste_sensitivity	0.72731743
92	MP0003879_abnormal_hair_cell	0.72157475
93	MP0002734_abnormal_mechanical_nocicepti	0.71105657
94	MP0003718_maternal_effect	0.70232625
95	MP0004270_analgesia	0.69782335
96	MP0002069_abnormal_eating/drinking_beha	0.68523936
97	MP0003953_abnormal_hormone_level	0.66663304
98	MP0002177_abnormal_outer_ear	0.66389254
99	MP0001963_abnormal_hearing_physiology	0.65779677
100	MP0009764_decreased_sensitivity_to	0.65578074

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Constricted visual fields (HP:0001133)	6.46665423
2	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	6.40911197
3	Abnormality of alanine metabolism (HP:0010916)	6.40911197
4	Hyperalaninemia (HP:0003348)	6.40911197
5	Congenital sensorineural hearing impairment (HP:0008527)	4.21115257
6	Generalized aminoaciduria (HP:0002909)	4.06153632
7	Decreased central vision (HP:0007663)	4.06113597
8	Reduced antithrombin III activity (HP:0001976)	3.17303001
9	Pendular nystagmus (HP:0012043)	3.15128086
10	Acute necrotizing encephalopathy (HP:0006965)	3.13137110
11	Short 1st metacarpal (HP:0010034)	3.01085312
12	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	3.01085312
13	Myocardial infarction (HP:0001658)	2.97612047
14	Methylmalonic acidemia (HP:0002912)	2.96433822
15	Proximal tubulopathy (HP:0000114)	2.91536531
16	Hepatic necrosis (HP:0002605)	2.90643254
17	Abnormal mitochondria in muscle tissue (HP:0008316)	2.90376548
18	Dry hair (HP:0011359)	2.88371677
19	Poor speech (HP:0002465)	2.85408818
20	Oligomenorrhea (HP:0000876)	2.83388621
21	Methylmalonic aciduria (HP:0012120)	2.80008165
22	Attenuation of retinal blood vessels (HP:0007843)	2.73794460
23	Progressive macrocephaly (HP:0004481)	2.73570669
24	Intrahepatic cholestasis (HP:0001406)	2.69323979
25	Nausea (HP:0002018)	2.68084648
26	Type I transferrin isoform profile (HP:0003642)	2.67632829
27	Hypoglycemic coma (HP:0001325)	2.65125021
28	Mitochondrial inheritance (HP:0001427)	2.64906920
29	Abnormality of the 1st metacarpal (HP:0010009)	2.63465727
30	Hypoalphalipoproteinemia (HP:0003233)	2.57363986
31	Decreased subcutaneous fat (HP:0001002)	2.57105517
32	Acute encephalopathy (HP:0006846)	2.54058750
33	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.51328593
34	Increased CSF lactate (HP:0002490)	2.48072895
35	Volvulus (HP:0002580)	2.45411456
36	Adrenal hypoplasia (HP:0000835)	2.43990191
37	Myopathic facies (HP:0002058)	2.43876762
38	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.41587577
39	Abnormality of the prostate (HP:0008775)	2.39155924
40	Ketoacidosis (HP:0001993)	2.38327973
41	Hepatocellular necrosis (HP:0001404)	2.37403644
42	Insulin-resistant diabetes mellitus (HP:0000831)	2.36737601
43	Abnormality of serum amino acid levels (HP:0003112)	2.32427673
44	Optic disc pallor (HP:0000543)	2.31988594
45	Increased serum lactate (HP:0002151)	2.31524836
46	Vascular calcification (HP:0004934)	2.31489100
47	Reduced subcutaneous adipose tissue (HP:0003758)	2.28310868
48	Large for gestational age (HP:0001520)	2.23343956
49	Fatigue (HP:0012378)	2.22919880
50	3-Methylglutaconic aciduria (HP:0003535)	2.22737188
51	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.22555352
52	Abnormality of methionine metabolism (HP:0010901)	2.19520963
53	Abnormality of homocysteine metabolism (HP:0010919)	2.16562384
54	Homocystinuria (HP:0002156)	2.16562384
55	Hypoproteinemia (HP:0003075)	2.15770991
56	Cerebral edema (HP:0002181)	2.14348345
57	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.14041674
58	Bony spicule pigmentary retinopathy (HP:0007737)	2.12668074
59	Glycosuria (HP:0003076)	2.12641706
60	Abnormality of urine glucose concentration (HP:0011016)	2.12641706
61	Increased corneal curvature (HP:0100692)	2.10234344
62	Keratoconus (HP:0000563)	2.10234344
63	Patchy hypopigmentation of hair (HP:0011365)	2.06478700
64	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.06057500
65	Abnormal protein N-linked glycosylation (HP:0012347)	2.06057500
66	Abnormal protein glycosylation (HP:0012346)	2.06057500
67	Abnormal glycosylation (HP:0012345)	2.06057500
68	Decreased circulating renin level (HP:0003351)	2.05203285
69	Abnormality of the fetal cardiovascular system (HP:0010948)	2.01826906
70	Abnormal umbilical cord blood vessels (HP:0011403)	2.01826906
71	Single umbilical artery (HP:0001195)	2.01826906
72	White forelock (HP:0002211)	2.01151189
73	Absent speech (HP:0001344)	1.99978077
74	Dicarboxylic aciduria (HP:0003215)	1.99679850
75	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.99679850
76	Renal cortical cysts (HP:0000803)	1.98261845
77	Radial bowing (HP:0002986)	1.95673555
78	Lactic acidosis (HP:0003128)	1.93981507
79	Short phalanx of the thumb (HP:0009660)	1.91192819
80	Increased serum pyruvate (HP:0003542)	1.89671389
81	Cardiovascular calcification (HP:0011915)	1.89131386
82	Truncal obesity (HP:0001956)	1.88868109
83	Exercise intolerance (HP:0003546)	1.87563056
84	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.86129002
85	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.85253198
86	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.85253198
87	Abnormal rod and cone electroretinograms (HP:0008323)	1.85008754
88	Conjunctival telangiectasia (HP:0000524)	1.84620494
89	Petechiae (HP:0000967)	1.82465814
90	Menorrhagia (HP:0000132)	1.80464168
91	Confusion (HP:0001289)	1.80283604
92	Conjugated hyperbilirubinemia (HP:0002908)	1.79455265
93	Abnormality of subcutaneous fat tissue (HP:0001001)	1.78337152
94	Metabolic acidosis (HP:0001942)	1.78096565
95	Paralysis (HP:0003470)	1.77755648
96	Delayed CNS myelination (HP:0002188)	1.77745875
97	Abnormal pupillary function (HP:0007686)	1.77311920
98	Hypophosphatemic rickets (HP:0004912)	1.74896971
99	Hyperlipoproteinemia (HP:0010980)	1.74574237
100	Hyperglycemia (HP:0003074)	1.72884234

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	9.55968923
2	TAF1	4.48003416
3	VRK2	4.32794481
4	MARK1	3.78041327
5	MST4	2.47901555
6	BUB1	2.09691742
7	CASK	2.07201096
8	PIK3CG	1.97877266
9	BMPR1B	1.95543832
10	GRK1	1.84143893
11	PHKG2	1.71221585
12	PHKG1	1.71221585
13	ARAF	1.56198372
14	CDK9	1.50843830
15	LIMK1	1.49786811
16	PDK2	1.36943401
17	DAPK1	1.36603819
18	AURKA	1.34816156
19	PNCK	1.32764762
20	LMTK2	1.28756843
21	CSNK1G3	1.25958132
22	FRK	1.17428748
23	GRK5	1.13132529
24	SMG1	1.09521175
25	CCNB1	1.08064640
26	NEK9	1.07084357
27	NTRK2	1.06672020
28	VRK1	1.05599175
29	FGR	1.04323777
30	CSNK1A1L	1.00416560
31	TESK1	0.99254713
32	MAP2K7	0.98135710
33	CSNK1G1	0.97989035
34	NUAK1	0.97877719
35	ADRBK2	0.97733791
36	MAP3K3	0.93096118
37	TESK2	0.89067517
38	CSNK1G2	0.85226767
39	PTK2B	0.83203464
40	MAP4K2	0.79769014
41	MYLK	0.79459986
42	MAP2K3	0.78239363
43	NEK1	0.75292254
44	ACVR1B	0.75203678
45	NME2	0.75186750
46	DAPK2	0.74871936
47	PBK	0.73209532
48	JAK3	0.72164753
49	PAK1	0.69120234
50	MOS	0.64174800
51	PINK1	0.61114465
52	PIM2	0.61011595
53	PLK2	0.60702849
54	DDR2	0.60673105
55	TRIM28	0.60205400
56	STK10	0.60022925
57	DAPK3	0.59685976
58	TIE1	0.55271243
59	EIF2AK3	0.53814188
60	CHEK2	0.51584332
61	ADRBK1	0.51557516
62	INSRR	0.49158469
63	PRKCI	0.49120472
64	SGK494	0.48193432
65	SGK223	0.48193432
66	HIPK2	0.47081103
67	BCKDK	0.46775226
68	EIF2AK1	0.46637398
69	TSSK6	0.45722537
70	CAMK1G	0.44370256
71	MAPKAPK5	0.44078861
72	TLK1	0.43780335
73	AURKB	0.43770011
74	CSNK1A1	0.43629606
75	TAOK3	0.43439406
76	SGK2	0.42689147
77	NME1	0.41908772
78	PLK3	0.37606690
79	MAPKAPK3	0.36959913
80	STK4	0.34953242
81	MATK	0.34304717
82	PRKCE	0.33787870
83	OBSCN	0.32654087
84	EPHA2	0.29723798
85	GRK7	0.29084720
86	DYRK2	0.27910572
87	CSNK2A2	0.27598651
88	RPS6KB1	0.27347909
89	MAP3K4	0.27224880
90	EPHB2	0.26973431
91	TNIK	0.26089328
92	CDK5	0.24710259
93	ATM	0.24315031
94	MAP3K12	0.24044314
95	ILK	0.22615922
96	GSK3A	0.22383359
97	TEC	0.22352934
98	CAMK2D	0.21886017
99	IKBKB	0.21744562
100	IKBKE	0.20080452

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	4.40860261
2	Proteasome_Homo sapiens_hsa03050	3.76178220
3	One carbon pool by folate_Homo sapiens_hsa00670	3.24587047
4	Sulfur metabolism_Homo sapiens_hsa00920	3.17488068
5	Oxidative phosphorylation_Homo sapiens_hsa00190	3.12094117
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.04902809
7	Collecting duct acid secretion_Homo sapiens_hsa04966	2.51394029
8	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.36199992
9	Parkinsons disease_Homo sapiens_hsa05012	2.16136696
10	Basal transcription factors_Homo sapiens_hsa03022	1.92927365
11	Sulfur relay system_Homo sapiens_hsa04122	1.90569778
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.83521544
13	Huntingtons disease_Homo sapiens_hsa05016	1.66264192
14	Folate biosynthesis_Homo sapiens_hsa00790	1.65222442
15	Alzheimers disease_Homo sapiens_hsa05010	1.57602012
16	Galactose metabolism_Homo sapiens_hsa00052	1.49743913
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.45132205
18	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.33633204
19	Vibrio cholerae infection_Homo sapiens_hsa05110	1.32102139
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.30315552
21	Arginine biosynthesis_Homo sapiens_hsa00220	1.26871415
22	Glutathione metabolism_Homo sapiens_hsa00480	1.26817147
23	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.24930173
24	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.22431490
25	Homologous recombination_Homo sapiens_hsa03440	1.22310516
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.22291998
27	Butanoate metabolism_Homo sapiens_hsa00650	1.21849537
28	Pyruvate metabolism_Homo sapiens_hsa00620	1.15687136
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.14216846
30	Asthma_Homo sapiens_hsa05310	1.13261422
31	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.12879077
32	Protein export_Homo sapiens_hsa03060	1.11525074
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.11365131
34	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.11227386
35	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.07646005
36	Peroxisome_Homo sapiens_hsa04146	1.07313353
37	DNA replication_Homo sapiens_hsa03030	1.06246916
38	Pyrimidine metabolism_Homo sapiens_hsa00240	1.04924492
39	RNA degradation_Homo sapiens_hsa03018	1.01302083
40	Arginine and proline metabolism_Homo sapiens_hsa00330	1.01134648
41	Spliceosome_Homo sapiens_hsa03040	0.98717667
42	Regulation of autophagy_Homo sapiens_hsa04140	0.98511868
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.98491186
44	Chemical carcinogenesis_Homo sapiens_hsa05204	0.98346884
45	Base excision repair_Homo sapiens_hsa03410	0.97779935
46	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.97721786
47	Nucleotide excision repair_Homo sapiens_hsa03420	0.91620739
48	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.90902790
49	Fatty acid elongation_Homo sapiens_hsa00062	0.90212696
50	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.87757408
51	Purine metabolism_Homo sapiens_hsa00230	0.86737114
52	Selenocompound metabolism_Homo sapiens_hsa00450	0.86287288
53	Allograft rejection_Homo sapiens_hsa05330	0.84138270
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.83908307
55	beta-Alanine metabolism_Homo sapiens_hsa00410	0.83769072
56	RNA polymerase_Homo sapiens_hsa03020	0.83760219
57	RNA transport_Homo sapiens_hsa03013	0.83638837
58	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.83263410
59	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.82500533
60	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.81344170
61	Taste transduction_Homo sapiens_hsa04742	0.80672892
62	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.79754443
63	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.78692042
64	Propanoate metabolism_Homo sapiens_hsa00640	0.78139029
65	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.76300014
66	Fanconi anemia pathway_Homo sapiens_hsa03460	0.75968411
67	Metabolic pathways_Homo sapiens_hsa01100	0.75231590
68	Morphine addiction_Homo sapiens_hsa05032	0.74988881
69	Mismatch repair_Homo sapiens_hsa03430	0.73924558
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.73817653
71	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.72286324
72	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.71542389
73	Nicotine addiction_Homo sapiens_hsa05033	0.70958680
74	Retinol metabolism_Homo sapiens_hsa00830	0.70872150
75	Mineral absorption_Homo sapiens_hsa04978	0.67409657
76	Salivary secretion_Homo sapiens_hsa04970	0.66498985
77	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.66207662
78	GABAergic synapse_Homo sapiens_hsa04727	0.62112181
79	Rheumatoid arthritis_Homo sapiens_hsa05323	0.61856582
80	Carbon metabolism_Homo sapiens_hsa01200	0.59329260
81	Serotonergic synapse_Homo sapiens_hsa04726	0.58988191
82	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.57879754
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.56523522
84	Type I diabetes mellitus_Homo sapiens_hsa04940	0.55575820
85	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.55356238
86	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.54175102
87	Ribosome_Homo sapiens_hsa03010	0.53165115
88	Sphingolipid metabolism_Homo sapiens_hsa00600	0.52926792
89	Cardiac muscle contraction_Homo sapiens_hsa04260	0.52610537
90	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.51901001
91	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.50228069
92	Pentose phosphate pathway_Homo sapiens_hsa00030	0.49659954
93	Olfactory transduction_Homo sapiens_hsa04740	0.47108486
94	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.46858176
95	Fatty acid degradation_Homo sapiens_hsa00071	0.46257485
96	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.44631574
97	Steroid biosynthesis_Homo sapiens_hsa00100	0.43936933
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43889365
99	Histidine metabolism_Homo sapiens_hsa00340	0.41914662
100	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.39649069

UBBP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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