UBBP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.24749223
2cytidine deamination (GO:0009972)5.22652464
3cytidine metabolic process (GO:0046087)5.22652464
4cytidine catabolic process (GO:0006216)5.22652464
5ATP synthesis coupled proton transport (GO:0015986)5.13893687
6energy coupled proton transport, down electrochemical gradient (GO:0015985)5.13893687
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.13278300
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.92333740
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.62470451
10ribosomal small subunit assembly (GO:0000028)4.44794670
11pyrimidine ribonucleoside catabolic process (GO:0046133)4.40149509
12respiratory electron transport chain (GO:0022904)4.32979484
13electron transport chain (GO:0022900)4.29168125
14proteasome assembly (GO:0043248)4.05224047
15protein complex biogenesis (GO:0070271)3.93978845
16protein neddylation (GO:0045116)3.90517854
17mitochondrial respiratory chain complex assembly (GO:0033108)3.67879280
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.66897024
19NADH dehydrogenase complex assembly (GO:0010257)3.66897024
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.66897024
21RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.59892150
22tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.59892150
23resolution of meiotic recombination intermediates (GO:0000712)3.54499828
24establishment of protein localization to mitochondrial membrane (GO:0090151)3.46756491
25protein-cofactor linkage (GO:0018065)3.45406086
26ATP biosynthetic process (GO:0006754)3.38939418
27regulation of cellular amino acid metabolic process (GO:0006521)3.27587262
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.27142910
29deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.26777027
30DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.18124287
31purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.13693826
32purine nucleoside triphosphate biosynthetic process (GO:0009145)3.13384404
33chaperone-mediated protein transport (GO:0072321)3.12137452
34pseudouridine synthesis (GO:0001522)3.11496673
35DNA methylation involved in gamete generation (GO:0043046)3.10721391
36positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.09914158
37positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.09009358
38synapsis (GO:0007129)3.08840109
39signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.08191115
40signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.08191115
41signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.08191115
42signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.07313637
43intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.07313637
44oxidative phosphorylation (GO:0006119)3.02941720
45termination of RNA polymerase III transcription (GO:0006386)2.98101405
46transcription elongation from RNA polymerase III promoter (GO:0006385)2.98101405
47positive regulation of ligase activity (GO:0051351)2.97703234
48negative regulation of ligase activity (GO:0051352)2.97166706
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.97166706
50respiratory chain complex IV assembly (GO:0008535)2.97008327
51piRNA metabolic process (GO:0034587)2.96664087
52signal transduction involved in DNA integrity checkpoint (GO:0072401)2.96640658
53signal transduction involved in DNA damage checkpoint (GO:0072422)2.96640658
54positive regulation of histone H3-K4 methylation (GO:0051571)2.96192933
55platelet dense granule organization (GO:0060155)2.95420712
56signal transduction involved in cell cycle checkpoint (GO:0072395)2.95335009
57terpenoid biosynthetic process (GO:0016114)2.94424337
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92224054
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91675570
60cytochrome complex assembly (GO:0017004)2.91339751
61pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.89811284
62viral transcription (GO:0019083)2.89109728
63maturation of SSU-rRNA (GO:0030490)2.88632029
64translation (GO:0006412)2.88596790
65hydrogen ion transmembrane transport (GO:1902600)2.85906695
66water-soluble vitamin biosynthetic process (GO:0042364)2.85888846
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83600874
68cellular component biogenesis (GO:0044085)2.82082525
69protein targeting to mitochondrion (GO:0006626)2.81561017
70anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81013184
71translational termination (GO:0006415)2.81000867
72ribosomal large subunit biogenesis (GO:0042273)2.79800858
73SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.79304177
74translational elongation (GO:0006414)2.79185218
75maturation of 5.8S rRNA (GO:0000460)2.77732060
76rRNA modification (GO:0000154)2.77280474
77DNA replication checkpoint (GO:0000076)2.76961907
78Arp2/3 complex-mediated actin nucleation (GO:0034314)2.74964037
79cotranslational protein targeting to membrane (GO:0006613)2.73853983
80protein targeting to ER (GO:0045047)2.73341003
81deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.71023705
82negative regulation by host of viral transcription (GO:0043922)2.70638958
83establishment of protein localization to mitochondrion (GO:0072655)2.69120126
84ribonucleoside triphosphate biosynthetic process (GO:0009201)2.68171285
85protein localization to endoplasmic reticulum (GO:0070972)2.67595682
86proton transport (GO:0015992)2.67530565
87actin nucleation (GO:0045010)2.64688225
88establishment of protein localization to endoplasmic reticulum (GO:0072599)2.61549195
892-deoxyribonucleotide biosynthetic process (GO:0009265)2.61235677
90deoxyribose phosphate biosynthetic process (GO:0046385)2.61235677
91base-excision repair, AP site formation (GO:0006285)2.60977471
92hydrogen transport (GO:0006818)2.60301177
93ribosome biogenesis (GO:0042254)2.59872520
94male meiosis (GO:0007140)2.59452690
95pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.58747577
96ubiquinone biosynthetic process (GO:0006744)2.58367773
97ribonucleoprotein complex biogenesis (GO:0022613)2.57939231
98regulation of ubiquitin-protein transferase activity (GO:0051438)2.57927554
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.55443882
100mannosylation (GO:0097502)2.54328562

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.51771714
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.08887608
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.66474736
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.52163307
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.51360394
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.49815969
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.39738543
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.37003007
9VDR_22108803_ChIP-Seq_LS180_Human3.32900984
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.15555973
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.88113771
12VDR_23849224_ChIP-Seq_CD4+_Human2.65268464
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47360892
14SRF_21415370_ChIP-Seq_HL-1_Mouse2.35112229
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32831944
16FOXP3_21729870_ChIP-Seq_TREG_Human2.30832956
17ELK1_19687146_ChIP-ChIP_HELA_Human2.27949659
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.18534040
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.13464640
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.12409186
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11203337
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10735345
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.03907514
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.00527431
25E2F7_22180533_ChIP-Seq_HELA_Human1.97861815
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.97794831
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.87787842
28ZNF274_21170338_ChIP-Seq_K562_Hela1.86001416
29MYC_18940864_ChIP-ChIP_HL60_Human1.80045586
30TTF2_22483619_ChIP-Seq_HELA_Human1.73440511
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.71938773
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67987158
33DCP1A_22483619_ChIP-Seq_HELA_Human1.66902197
34XRN2_22483619_ChIP-Seq_HELA_Human1.60325694
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58214174
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57478879
37GABP_19822575_ChIP-Seq_HepG2_Human1.52823594
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52571778
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.45371274
40TP53_22573176_ChIP-Seq_HFKS_Human1.43406139
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38707893
42CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36994021
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31371063
44EZH2_22144423_ChIP-Seq_EOC_Human1.30698835
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29541266
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29526370
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28331174
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27105304
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25305780
50IGF1R_20145208_ChIP-Seq_DFB_Human1.24646260
51CIITA_25753668_ChIP-Seq_RAJI_Human1.24577491
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24166414
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23496058
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21801161
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20118091
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19457784
57MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18904732
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17596930
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16051698
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.14782862
61PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14255196
62CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.14228443
63NANOG_20526341_ChIP-Seq_ESCs_Human1.13000144
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12919920
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.11017446
66TAF2_19829295_ChIP-Seq_ESCs_Human1.11001095
67NCOR_22424771_ChIP-Seq_293T_Human1.10239313
68EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08272448
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07331860
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07002811
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06921698
72RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06015754
73AR_20517297_ChIP-Seq_VCAP_Human1.04878754
74PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.04346109
75CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04218084
76FOXA1_25329375_ChIP-Seq_VCAP_Human1.04095620
77FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04095620
78ERG_20517297_ChIP-Seq_VCAP_Human1.03469460
79YY1_22570637_ChIP-Seq_MALME-3M_Human1.02821061
80FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02601716
81EWS_26573619_Chip-Seq_HEK293_Human1.02335422
82KDM5A_27292631_Chip-Seq_BREAST_Human1.01287935
83GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00260260
84GATA6_21074721_ChIP-Seq_CACO-2_Human0.99749743
85GATA3_21878914_ChIP-Seq_MCF-7_Human0.99565436
86PHF8_20622853_ChIP-Seq_HELA_Human0.98434452
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97377971
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96829781
89BCL6_27268052_Chip-Seq_Bcells_Human0.94615414
90P53_21459846_ChIP-Seq_SAOS-2_Human0.94445358
91MYC_19829295_ChIP-Seq_ESCs_Human0.92898617
92MYB_26560356_Chip-Seq_TH2_Human0.92725662
93AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92392615
94P300_27268052_Chip-Seq_Bcells_Human0.91737965
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91459754
96RBPJ_21746931_ChIP-Seq_IB4_Human0.90808017
97MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90685726
98YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90583836
99RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90326676
100IRF1_19129219_ChIP-ChIP_H3396_Human0.89812396

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level3.88205953
2MP0008995_early_reproductive_senescence3.14670207
3MP0004145_abnormal_muscle_electrophysio3.00745173
4MP0003786_premature_aging2.72221606
5MP0008877_abnormal_DNA_methylation2.67775694
6MP0008058_abnormal_DNA_repair2.66675907
7MP0005671_abnormal_response_to2.47874190
8MP0005645_abnormal_hypothalamus_physiol2.18531457
9MP0003693_abnormal_embryo_hatching2.15982936
10MP0006036_abnormal_mitochondrial_physio2.10485978
11MP0006072_abnormal_retinal_apoptosis2.08884875
12MP0000372_irregular_coat_pigmentation2.05767465
13MP0005646_abnormal_pituitary_gland2.02664287
14MP0006292_abnormal_olfactory_placode1.96121802
15MP0003646_muscle_fatigue1.87810028
16MP0002102_abnormal_ear_morphology1.87742965
17MP0003806_abnormal_nucleotide_metabolis1.84186610
18MP0005083_abnormal_biliary_tract1.81753798
19MP0006276_abnormal_autonomic_nervous1.77196834
20MP0002837_dystrophic_cardiac_calcinosis1.77062918
21MP0008872_abnormal_physiological_respon1.75733162
22MP0009697_abnormal_copulation1.74108218
23MP0003718_maternal_effect1.73809829
24MP0005410_abnormal_fertilization1.67802271
25MP0005360_urolithiasis1.67736340
26MP0000678_abnormal_parathyroid_gland1.52558696
27MP0005636_abnormal_mineral_homeostasis1.50994620
28MP0002638_abnormal_pupillary_reflex1.50968739
29MP0002138_abnormal_hepatobiliary_system1.50946757
30MP0001968_abnormal_touch/_nociception1.50339602
31MP0003186_abnormal_redox_activity1.50293168
32MP0009333_abnormal_splenocyte_physiolog1.50234624
33MP0002163_abnormal_gland_morphology1.49063927
34MP0008875_abnormal_xenobiotic_pharmacok1.44854725
35MP0005389_reproductive_system_phenotype1.43272870
36MP0006035_abnormal_mitochondrial_morpho1.42859040
37MP0002210_abnormal_sex_determination1.41846431
38MP0001929_abnormal_gametogenesis1.39675155
39MP0002736_abnormal_nociception_after1.39015606
40MP0010094_abnormal_chromosome_stability1.38463584
41MP0002160_abnormal_reproductive_system1.36218527
42MP0001919_abnormal_reproductive_system1.35218877
43MP0004957_abnormal_blastocyst_morpholog1.34418051
44MP0004885_abnormal_endolymph1.30019345
45MP0001873_stomach_inflammation1.28255526
46MP0001661_extended_life_span1.26449466
47MP0009379_abnormal_foot_pigmentation1.26334109
48MP0004142_abnormal_muscle_tone1.26069530
49MP0002095_abnormal_skin_pigmentation1.24250675
50MP0001835_abnormal_antigen_presentation1.23996836
51MP0001905_abnormal_dopamine_level1.23628312
52MP0001764_abnormal_homeostasis1.23340581
53MP0005551_abnormal_eye_electrophysiolog1.20059794
54MP0002876_abnormal_thyroid_physiology1.18933575
55MP0009785_altered_susceptibility_to1.18744841
56MP0005253_abnormal_eye_physiology1.17367301
57MP0001529_abnormal_vocalization1.10368712
58MP0003698_abnormal_male_reproductive1.09746660
59MP0008007_abnormal_cellular_replicative1.09588640
60MP0003195_calcinosis1.09501814
61MP0008789_abnormal_olfactory_epithelium1.09178999
62MP0000653_abnormal_sex_gland1.06541275
63MP0008775_abnormal_heart_ventricle1.05109387
64MP0002132_abnormal_respiratory_system1.04374169
65MP0001145_abnormal_male_reproductive1.00876062
66MP0004019_abnormal_vitamin_homeostasis0.99526520
67MP0004043_abnormal_pH_regulation0.97396299
68MP0003787_abnormal_imprinting0.96890826
69MP0005084_abnormal_gallbladder_morpholo0.96215639
70MP0002693_abnormal_pancreas_physiology0.96134767
71MP0001119_abnormal_female_reproductive0.94814524
72MP0000631_abnormal_neuroendocrine_gland0.93397410
73MP0005332_abnormal_amino_acid0.92368241
74MP0003959_abnormal_lean_body0.89895862
75MP0000703_abnormal_thymus_morphology0.89134373
76MP0002733_abnormal_thermal_nociception0.88060125
77MP0003763_abnormal_thymus_physiology0.85432188
78MP0002398_abnormal_bone_marrow0.83088223
79MP0003111_abnormal_nucleus_morphology0.82613977
80MP0002148_abnormal_hypersensitivity_rea0.81144205
81MP0001502_abnormal_circadian_rhythm0.81092558
82MP0003137_abnormal_impulse_conducting0.81024177
83MP0002272_abnormal_nervous_system0.80507396
84MP0002722_abnormal_immune_system0.80383562
85MP0002723_abnormal_immune_serum0.78913067
86MP0002139_abnormal_hepatobiliary_system0.78663048
87MP0001765_abnormal_ion_homeostasis0.77394025
88MP0000689_abnormal_spleen_morphology0.76802449
89MP0002420_abnormal_adaptive_immunity0.76135690
90MP0009046_muscle_twitch0.74766376
91MP0001819_abnormal_immune_cell0.73081283
92MP0002277_abnormal_respiratory_mucosa0.72133602
93MP0009643_abnormal_urine_homeostasis0.71899485
94MP0005379_endocrine/exocrine_gland_phen0.70853064
95MP0005085_abnormal_gallbladder_physiolo0.70775104
96MP0002653_abnormal_ependyma_morphology0.69488854
97MP0005025_abnormal_response_to0.69484295
98MP0005000_abnormal_immune_tolerance0.68834978
99MP0002429_abnormal_blood_cell0.68671141
100MP0003866_abnormal_defecation0.68243998

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.01568587
2Abnormal mitochondria in muscle tissue (HP:0008316)4.66676045
3Acute encephalopathy (HP:0006846)4.37527641
4Mitochondrial inheritance (HP:0001427)4.28178754
5Progressive macrocephaly (HP:0004481)4.20445994
6Increased CSF lactate (HP:0002490)3.94206040
7Aplastic anemia (HP:0001915)3.51410078
8Hepatocellular necrosis (HP:0001404)3.44396478
9Cerebral edema (HP:0002181)3.43106461
10Hepatic necrosis (HP:0002605)3.38193368
113-Methylglutaconic aciduria (HP:0003535)3.37953834
12Increased hepatocellular lipid droplets (HP:0006565)3.15854504
13Lipid accumulation in hepatocytes (HP:0006561)2.98172886
14Increased intramyocellular lipid droplets (HP:0012240)2.92326368
15Increased serum lactate (HP:0002151)2.86670644
16Decreased activity of mitochondrial respiratory chain (HP:0008972)2.85681835
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.85681835
18Reticulocytopenia (HP:0001896)2.85351162
19Hypoproteinemia (HP:0003075)2.81212586
20Lactic acidosis (HP:0003128)2.77279462
21Renal Fanconi syndrome (HP:0001994)2.76046265
22Optic disc pallor (HP:0000543)2.72936220
23Abnormal number of erythroid precursors (HP:0012131)2.64880396
24Methylmalonic acidemia (HP:0002912)2.61549662
25Congenital stationary night blindness (HP:0007642)2.58284971
26Abnormality of cells of the erythroid lineage (HP:0012130)2.57013371
27Absent rod-and cone-mediated responses on ERG (HP:0007688)2.54660705
28Methylmalonic aciduria (HP:0012120)2.54127712
29Pancreatic cysts (HP:0001737)2.53141336
30Generalized aminoaciduria (HP:0002909)2.43439504
31Increased muscle lipid content (HP:0009058)2.43206135
32Respiratory failure (HP:0002878)2.38514552
33Abnormal rod and cone electroretinograms (HP:0008323)2.38505340
34Abnormality of the heme biosynthetic pathway (HP:0010472)2.38410808
35Pancytopenia (HP:0001876)2.36909695
36Pancreatic fibrosis (HP:0100732)2.36774597
37Hyperthyroidism (HP:0000836)2.36213031
38Lethargy (HP:0001254)2.33917497
39Abnormality of the renal collecting system (HP:0004742)2.32978204
40Exercise intolerance (HP:0003546)2.32309420
41IgG deficiency (HP:0004315)2.31792010
42Severe combined immunodeficiency (HP:0004430)2.31669660
43Truncus arteriosus (HP:0001660)2.30568303
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.29857336
45Renal cortical cysts (HP:0000803)2.29045330
46True hermaphroditism (HP:0010459)2.25600682
47Cholecystitis (HP:0001082)2.23122318
48Abnormal gallbladder physiology (HP:0012438)2.23122318
49Exertional dyspnea (HP:0002875)2.19391061
50Pallor (HP:0000980)2.19318979
51Abnormality of urine glucose concentration (HP:0011016)2.18076824
52Glycosuria (HP:0003076)2.18076824
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17032470
54Attenuation of retinal blood vessels (HP:0007843)2.16779528
55Molar tooth sign on MRI (HP:0002419)2.16201285
56Abnormality of midbrain morphology (HP:0002418)2.16201285
57Abnormality of DNA repair (HP:0003254)2.13062496
58Dicarboxylic aciduria (HP:0003215)2.12537209
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.12537209
60Hyperalaninemia (HP:0003348)2.12457274
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12457274
62Abnormality of alanine metabolism (HP:0010916)2.12457274
63Abnormality of the renal cortex (HP:0011035)2.06689388
64Absent thumb (HP:0009777)2.04392823
65Type I transferrin isoform profile (HP:0003642)2.00696895
66Constricted visual fields (HP:0001133)1.99181159
67Decreased electroretinogram (ERG) amplitude (HP:0000654)1.97542197
68Increased serum pyruvate (HP:0003542)1.95937652
69Abnormality of the prostate (HP:0008775)1.95910757
70Duplicated collecting system (HP:0000081)1.94987443
71Abnormality of reticulocytes (HP:0004312)1.94360175
72Macrocytic anemia (HP:0001972)1.92620146
73Oral leukoplakia (HP:0002745)1.92204556
74Palpitations (HP:0001962)1.90704402
75Leukodystrophy (HP:0002415)1.88544991
76Abolished electroretinogram (ERG) (HP:0000550)1.88444335
77Abnormal hemoglobin (HP:0011902)1.88159013
78Combined immunodeficiency (HP:0005387)1.85462561
79Ileus (HP:0002595)1.83988504
80Abnormality of vitamin B metabolism (HP:0004340)1.82452994
81Abnormality of B cell number (HP:0010975)1.82425423
82Chromsome breakage (HP:0040012)1.80919080
83Abnormality of the pons (HP:0007361)1.79401296
84Chromosomal breakage induced by crosslinking agents (HP:0003221)1.78934217
85Abnormality of the vitamin B12 metabolism (HP:0004341)1.78582175
86Concave nail (HP:0001598)1.78215762
87Decreased central vision (HP:0007663)1.77688996
88Abnormality of renal resorption (HP:0011038)1.75559635
89Elevated erythrocyte sedimentation rate (HP:0003565)1.74879813
90Aplasia/Hypoplasia of the uvula (HP:0010293)1.74024742
91Hypoplasia of the pons (HP:0012110)1.72980094
92Autoimmune hemolytic anemia (HP:0001890)1.72510827
93Abnormality of T cells (HP:0002843)1.72156583
94Respiratory difficulties (HP:0002880)1.71932402
95Pendular nystagmus (HP:0012043)1.70900690
96Severe visual impairment (HP:0001141)1.69838421
97Abnormality of homocysteine metabolism (HP:0010919)1.69680664
98Homocystinuria (HP:0002156)1.69680664
99CNS demyelination (HP:0007305)1.67875971
100Sclerocornea (HP:0000647)1.67499094

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.98938619
2VRK22.82815549
3KDR2.82679850
4BCKDK2.76959808
5TESK22.70592026
6MST42.60119115
7TAOK32.54038249
8MAP4K22.37209044
9ZAK2.28597187
10ADRBK22.14193418
11NUAK11.98032846
12WNK41.93395792
13PINK11.90009912
14BUB11.83255618
15EIF2AK11.81465857
16GRK11.78621427
17TLK11.77854699
18VRK11.70609756
19EIF2AK31.56647626
20STK161.56486679
21NME11.44402386
22FRK1.38712677
23SRPK11.38517489
24LIMK11.38123089
25NME21.38068824
26RIPK41.36764262
27CLK11.35478539
28MAP3K91.34567602
29PLK41.32239828
30TEC1.30692098
31BMPR21.27851653
32MAP4K11.21065620
33PIK3CG1.20199331
34MUSK1.17468729
35PHKG11.13350425
36PHKG21.13350425
37MAPK131.10306090
38ITK1.10198510
39MAPKAPK31.09372812
40RPS6KA51.04281187
41BMPR1B1.00821098
42CCNB10.97717158
43NTRK30.97649686
44MAP3K120.96846649
45TIE10.96291497
46NEK10.94396160
47CSNK1G30.91084221
48AURKA0.90767750
49CHEK20.89303073
50MAP3K40.87650418
51RAF10.87569188
52TTK0.85286918
53SYK0.84831385
54PAK10.78341225
55MAP2K70.77910131
56INSRR0.77330821
57ATR0.72884068
58MAPKAPK50.71730095
59TSSK60.69588155
60PLK30.69376996
61CSNK1G10.69358676
62PLK20.68906062
63CSNK1G20.68896758
64OBSCN0.68475317
65WNK30.67843981
66DYRK20.67555759
67CDC70.66341075
68GRK70.65892521
69BTK0.64325634
70CDK80.62155858
71PRKCQ0.61690478
72SCYL20.61365825
73PASK0.60527263
74CSNK2A20.59669901
75TESK10.59568443
76PDK20.59053923
77CAMKK20.57584552
78DAPK10.57200693
79ILK0.56386352
80CSNK2A10.54124140
81WEE10.53401030
82CSNK1A1L0.51464191
83TNIK0.50085123
84PLK10.48395681
85TRIM280.47532848
86JAK30.45146457
87MYLK0.45020956
88PIM10.43627253
89PIM20.43119428
90ARAF0.42603802
91IKBKB0.42145765
92PRKACA0.42036638
93ATM0.41661167
94AURKB0.40006182
95LCK0.38278169
96LYN0.37361771
97MATK0.34679949
98PRKCI0.34547158
99PRKCA0.34519398
100RPS6KA40.34252094

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.05404551
2Oxidative phosphorylation_Homo sapiens_hsa001904.01821895
3Ribosome_Homo sapiens_hsa030103.45536586
4Parkinsons disease_Homo sapiens_hsa050123.44594609
5RNA polymerase_Homo sapiens_hsa030202.50268221
6Protein export_Homo sapiens_hsa030602.37850232
7Huntingtons disease_Homo sapiens_hsa050162.24504541
8Alzheimers disease_Homo sapiens_hsa050102.19737167
9Primary immunodeficiency_Homo sapiens_hsa053402.17389980
10Homologous recombination_Homo sapiens_hsa034402.11336593
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.08809116
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.03569262
13One carbon pool by folate_Homo sapiens_hsa006702.03567586
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01101373
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.00146322
16Mismatch repair_Homo sapiens_hsa034301.73536990
17Basal transcription factors_Homo sapiens_hsa030221.69563256
18Fanconi anemia pathway_Homo sapiens_hsa034601.66787537
19DNA replication_Homo sapiens_hsa030301.64518746
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64071051
21Cardiac muscle contraction_Homo sapiens_hsa042601.62361448
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.49030982
23Pyrimidine metabolism_Homo sapiens_hsa002401.47851838
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44564357
25RNA degradation_Homo sapiens_hsa030181.42157022
26Nucleotide excision repair_Homo sapiens_hsa034201.37518429
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34274382
28Sulfur metabolism_Homo sapiens_hsa009201.33163118
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30477967
30Butanoate metabolism_Homo sapiens_hsa006501.28400169
31Spliceosome_Homo sapiens_hsa030401.26886213
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.24898111
33RNA transport_Homo sapiens_hsa030131.24769374
34Autoimmune thyroid disease_Homo sapiens_hsa053201.24566574
35Propanoate metabolism_Homo sapiens_hsa006401.24470580
36Antigen processing and presentation_Homo sapiens_hsa046121.22800051
37Purine metabolism_Homo sapiens_hsa002301.22173363
38Graft-versus-host disease_Homo sapiens_hsa053321.21284775
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18157386
40Allograft rejection_Homo sapiens_hsa053301.17359665
41Asthma_Homo sapiens_hsa053101.14158612
42Phototransduction_Homo sapiens_hsa047441.12079496
43Nitrogen metabolism_Homo sapiens_hsa009101.11941683
44Olfactory transduction_Homo sapiens_hsa047401.10036436
45Type I diabetes mellitus_Homo sapiens_hsa049401.08872635
46Base excision repair_Homo sapiens_hsa034101.07796526
47Pyruvate metabolism_Homo sapiens_hsa006201.03242847
48Linoleic acid metabolism_Homo sapiens_hsa005911.01768084
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.96503428
50Sulfur relay system_Homo sapiens_hsa041220.94562533
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.93775385
52Peroxisome_Homo sapiens_hsa041460.90739408
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90179618
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87630181
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85919898
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80117527
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79960889
58Metabolic pathways_Homo sapiens_hsa011000.77082222
59Selenocompound metabolism_Homo sapiens_hsa004500.76874187
60Caffeine metabolism_Homo sapiens_hsa002320.76165492
61Retinol metabolism_Homo sapiens_hsa008300.74509986
62Steroid biosynthesis_Homo sapiens_hsa001000.72496086
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69736604
64Rheumatoid arthritis_Homo sapiens_hsa053230.69499614
65Fatty acid elongation_Homo sapiens_hsa000620.68757645
66Fat digestion and absorption_Homo sapiens_hsa049750.68085433
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67853916
68Hematopoietic cell lineage_Homo sapiens_hsa046400.67173176
69Glutathione metabolism_Homo sapiens_hsa004800.66673887
70Chemical carcinogenesis_Homo sapiens_hsa052040.64221522
71Collecting duct acid secretion_Homo sapiens_hsa049660.57979973
72Folate biosynthesis_Homo sapiens_hsa007900.57545351
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57408396
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52397542
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.52331948
76Tryptophan metabolism_Homo sapiens_hsa003800.50005342
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48886110
78Carbon metabolism_Homo sapiens_hsa012000.47583082
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.46630787
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43687537
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43611437
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.43159960
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43072414
84Regulation of autophagy_Homo sapiens_hsa041400.42826867
85Ether lipid metabolism_Homo sapiens_hsa005650.41751206
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41621332
87Systemic lupus erythematosus_Homo sapiens_hsa053220.41241707
88Nicotine addiction_Homo sapiens_hsa050330.41086437
89Biosynthesis of amino acids_Homo sapiens_hsa012300.40029615
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39075498
91Arachidonic acid metabolism_Homo sapiens_hsa005900.38836985
92Arginine biosynthesis_Homo sapiens_hsa002200.33704262
93T cell receptor signaling pathway_Homo sapiens_hsa046600.32557038
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30672471
95Mineral absorption_Homo sapiens_hsa049780.29476851
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26646023
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.26280153
98Taste transduction_Homo sapiens_hsa047420.23311334
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23241402
100Vitamin digestion and absorption_Homo sapiens_hsa049770.22437904

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »