UBBP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.87926933
2L-serine transport (GO:0015825)4.79011552
3behavioral response to nicotine (GO:0035095)4.68509450
4somite rostral/caudal axis specification (GO:0032525)4.02498436
5serine transport (GO:0032329)3.98399376
6ATP synthesis coupled proton transport (GO:0015986)3.91759027
7energy coupled proton transport, down electrochemical gradient (GO:0015985)3.91759027
8ribosomal small subunit assembly (GO:0000028)3.82107705
9indolalkylamine metabolic process (GO:0006586)3.73286879
10water-soluble vitamin biosynthetic process (GO:0042364)3.72335064
11kidney morphogenesis (GO:0060993)3.71513897
12regulation of mesoderm development (GO:2000380)3.69860352
13negative regulation of activin receptor signaling pathway (GO:0032926)3.68057819
14platelet dense granule organization (GO:0060155)3.64205275
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.64119530
16glycerophospholipid catabolic process (GO:0046475)3.60665084
17neuron fate determination (GO:0048664)3.54269881
18photoreceptor cell maintenance (GO:0045494)3.53058841
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.52963919
20maturation of SSU-rRNA (GO:0030490)3.46223026
21chromatin remodeling at centromere (GO:0031055)3.39564859
22establishment of protein localization to mitochondrial membrane (GO:0090151)3.32786155
23transcription elongation from RNA polymerase III promoter (GO:0006385)3.30185996
24termination of RNA polymerase III transcription (GO:0006386)3.30185996
25regulation of male gonad development (GO:2000018)3.28678384
26rRNA catabolic process (GO:0016075)3.26619322
27exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.26111415
28nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19377750
29protein neddylation (GO:0045116)3.18493996
30lateral ventricle development (GO:0021670)3.17294694
31detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.15137042
32CENP-A containing nucleosome assembly (GO:0034080)3.12891999
33positive regulation of gastrulation (GO:2000543)3.11929380
34cellular biogenic amine biosynthetic process (GO:0042401)3.05581463
35chaperone-mediated protein transport (GO:0072321)3.04460508
36anterograde synaptic vesicle transport (GO:0048490)3.03017352
37replication fork processing (GO:0031297)3.02500319
38phosphatidylserine metabolic process (GO:0006658)3.01420178
39regulation of action potential (GO:0098900)3.00164214
40ribosomal small subunit biogenesis (GO:0042274)2.99678502
41primitive streak formation (GO:0090009)2.96707279
42transmission of nerve impulse (GO:0019226)2.95675078
43translational termination (GO:0006415)2.95561053
44histone exchange (GO:0043486)2.94743727
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.93735855
46mitochondrial respiratory chain complex I assembly (GO:0032981)2.93735855
47NADH dehydrogenase complex assembly (GO:0010257)2.93735855
48viral transcription (GO:0019083)2.92254449
49protein complex biogenesis (GO:0070271)2.90264900
50SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.89566846
51preassembly of GPI anchor in ER membrane (GO:0016254)2.88791245
52endoderm formation (GO:0001706)2.88285348
53cotranslational protein targeting to membrane (GO:0006613)2.88250691
54protein targeting to ER (GO:0045047)2.86420454
55parturition (GO:0007567)2.86347982
56DNA methylation involved in gamete generation (GO:0043046)2.85234540
57amine biosynthetic process (GO:0009309)2.81184845
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.77021870
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.77021870
60synaptic transmission, cholinergic (GO:0007271)2.75568236
61synapsis (GO:0007129)2.73059464
62intracellular protein transmembrane import (GO:0044743)2.72915986
63RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.72754992
64protein localization to endoplasmic reticulum (GO:0070972)2.72027909
65signal transduction involved in regulation of gene expression (GO:0023019)2.71768103
66establishment of protein localization to endoplasmic reticulum (GO:0072599)2.70621032
67mitochondrial respiratory chain complex assembly (GO:0033108)2.69023989
68respiratory chain complex IV assembly (GO:0008535)2.68606794
69mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.66070399
70pyrimidine nucleobase catabolic process (GO:0006208)2.65730163
71regulation of cilium movement (GO:0003352)2.64422483
72embryonic axis specification (GO:0000578)2.63504675
73piRNA metabolic process (GO:0034587)2.61340618
74epithelial cilium movement (GO:0003351)2.61056007
75glycosphingolipid biosynthetic process (GO:0006688)2.60287269
76protein K6-linked ubiquitination (GO:0085020)2.60215417
77GTP biosynthetic process (GO:0006183)2.58564841
78translation (GO:0006412)2.57919587
79termination of RNA polymerase I transcription (GO:0006363)2.57631551
80positive regulation of protein autophosphorylation (GO:0031954)2.57440539
81ketone body metabolic process (GO:1902224)2.57318407
82brain morphogenesis (GO:0048854)2.56785931
83cell migration involved in gastrulation (GO:0042074)2.56234204
84anterior/posterior axis specification (GO:0009948)2.54451589
85anterior/posterior axis specification, embryo (GO:0008595)2.52099599
86ncRNA catabolic process (GO:0034661)2.51537224
87retinal rod cell development (GO:0046548)2.50782438
88epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.48407068
89translational elongation (GO:0006414)2.47288402
90sensory perception of smell (GO:0007608)2.45511023
91anterograde axon cargo transport (GO:0008089)2.44018697
92startle response (GO:0001964)2.43655530
93short-chain fatty acid metabolic process (GO:0046459)2.42651652
94regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.42221854
95proton transport (GO:0015992)2.41914290
96cellular response to cholesterol (GO:0071397)2.41163662
97negative regulation of DNA-dependent DNA replication (GO:2000104)2.41024663
98tRNA processing (GO:0008033)2.39672713
99negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.39631657
100electron transport chain (GO:0022900)2.39402267

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.76718149
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.33602940
3VDR_22108803_ChIP-Seq_LS180_Human3.25446780
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.20078814
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.98620595
6ZNF274_21170338_ChIP-Seq_K562_Hela2.67860276
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.59359554
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.54024250
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.53755654
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51950652
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.51434462
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47634313
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.26128927
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.23316674
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14413064
16P300_19829295_ChIP-Seq_ESCs_Human2.08794205
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95742758
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88029078
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80140700
20FUS_26573619_Chip-Seq_HEK293_Human1.79477810
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76661873
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.75003301
23ELK1_19687146_ChIP-ChIP_HELA_Human1.73862766
24SMAD3_21741376_ChIP-Seq_EPCs_Human1.71637489
25GBX2_23144817_ChIP-Seq_PC3_Human1.69290079
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66582263
27SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.61412105
28EWS_26573619_Chip-Seq_HEK293_Human1.59401311
29SMAD3_21741376_ChIP-Seq_HESCs_Human1.56962980
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55987493
31MYC_18940864_ChIP-ChIP_HL60_Human1.54731255
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54627141
33VDR_23849224_ChIP-Seq_CD4+_Human1.50208057
34BCAT_22108803_ChIP-Seq_LS180_Human1.49581018
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47192753
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42171988
37TP53_22573176_ChIP-Seq_HFKS_Human1.40931556
38SMAD4_21741376_ChIP-Seq_EPCs_Human1.36785816
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34235634
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34133790
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32436282
42SMAD4_21741376_ChIP-Seq_HESCs_Human1.32146788
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30376731
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28430714
45IGF1R_20145208_ChIP-Seq_DFB_Human1.27663872
46TCF4_22108803_ChIP-Seq_LS180_Human1.26345745
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24740051
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24593490
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.24396774
50IRF1_19129219_ChIP-ChIP_H3396_Human1.22857850
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19448622
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18354800
53ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18014349
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17982582
55TAF15_26573619_Chip-Seq_HEK293_Human1.17860300
56FOXP3_21729870_ChIP-Seq_TREG_Human1.17070200
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16886981
58AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16679769
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14670410
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.14263836
61KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14160746
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.12851155
63NANOG_19829295_ChIP-Seq_ESCs_Human1.12195428
64SOX2_19829295_ChIP-Seq_ESCs_Human1.12195428
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11854026
66SMAD4_21799915_ChIP-Seq_A2780_Human1.11429519
67REST_21632747_ChIP-Seq_MESCs_Mouse1.09966529
68RUNX2_22187159_ChIP-Seq_PCA_Human1.07713825
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07470923
70NCOR_22424771_ChIP-Seq_293T_Human1.05466673
71E2F4_17652178_ChIP-ChIP_JURKAT_Human1.05451174
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04201817
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02030911
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99481329
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99374773
76STAT3_23295773_ChIP-Seq_U87_Human0.97945974
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97876239
78EZH2_27304074_Chip-Seq_ESCs_Mouse0.97773162
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96641345
80JUN_21703547_ChIP-Seq_K562_Human0.95545527
81AR_25329375_ChIP-Seq_VCAP_Human0.95543943
82AR_20517297_ChIP-Seq_VCAP_Human0.94740446
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94716583
84CDX2_22108803_ChIP-Seq_LS180_Human0.94255579
85SOX2_16153702_ChIP-ChIP_HESCs_Human0.93698732
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92130842
87EZH2_27294783_Chip-Seq_NPCs_Mouse0.91985681
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91525112
89FOXA1_25329375_ChIP-Seq_VCAP_Human0.91383797
90FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91383797
91SMAD3_21741376_ChIP-Seq_ESCs_Human0.90811643
92CBX2_27304074_Chip-Seq_ESCs_Mouse0.90032206
93PRDM14_20953172_ChIP-Seq_ESCs_Human0.89747903
94PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89556352
95KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88933301
96RNF2_27304074_Chip-Seq_NSC_Mouse0.88470798
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.87919563
98ETV1_20927104_ChIP-Seq_GIST48_Human0.87006574
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.86149022
100TCF4_23295773_ChIP-Seq_U87_Human0.85909588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005499_abnormal_olfactory_system4.45941904
2MP0005394_taste/olfaction_phenotype4.45941904
3MP0006292_abnormal_olfactory_placode4.20136911
4MP0003890_abnormal_embryonic-extraembry3.64489241
5MP0002102_abnormal_ear_morphology3.62005260
6MP0003787_abnormal_imprinting3.49778135
7MP0009379_abnormal_foot_pigmentation3.41066783
8MP0001984_abnormal_olfaction3.39587647
9MP0004145_abnormal_muscle_electrophysio3.36254567
10MP0008789_abnormal_olfactory_epithelium3.27906986
11MP0008877_abnormal_DNA_methylation3.13041151
12MP0003136_yellow_coat_color2.82316138
13MP0003122_maternal_imprinting2.19710576
14MP0003121_genomic_imprinting2.08839495
15MP0001968_abnormal_touch/_nociception2.01065220
16MP0002234_abnormal_pharynx_morphology1.94757765
17MP0008872_abnormal_physiological_respon1.88705335
18MP0005084_abnormal_gallbladder_morpholo1.80288841
19MP0004133_heterotaxia1.77852126
20MP0008058_abnormal_DNA_repair1.76231175
21MP0003119_abnormal_digestive_system1.75506168
22MP0000372_irregular_coat_pigmentation1.75352197
23MP0005174_abnormal_tail_pigmentation1.73043924
24MP0002736_abnormal_nociception_after1.72877071
25MP0002837_dystrophic_cardiac_calcinosis1.67695161
26MP0004885_abnormal_endolymph1.66659882
27MP0006276_abnormal_autonomic_nervous1.66132684
28MP0002938_white_spotting1.64161230
29MP0008875_abnormal_xenobiotic_pharmacok1.63354870
30MP0002184_abnormal_innervation1.49235369
31MP0001188_hyperpigmentation1.48778865
32MP0002138_abnormal_hepatobiliary_system1.45021676
33MP0001986_abnormal_taste_sensitivity1.44765453
34MP0005551_abnormal_eye_electrophysiolog1.42618422
35MP0001529_abnormal_vocalization1.41670003
36MP0001293_anophthalmia1.37914771
37MP0004147_increased_porphyrin_level1.37357208
38MP0001485_abnormal_pinna_reflex1.35557861
39MP0005075_abnormal_melanosome_morpholog1.34055334
40MP0003718_maternal_effect1.32952907
41MP0004742_abnormal_vestibular_system1.30136092
42MP0009745_abnormal_behavioral_response1.26841454
43MP0005645_abnormal_hypothalamus_physiol1.20199081
44MP0006035_abnormal_mitochondrial_morpho1.20177407
45MP0002272_abnormal_nervous_system1.19431749
46MP0003880_abnormal_central_pattern1.18962061
47MP0005377_hearing/vestibular/ear_phenot1.16527241
48MP0003878_abnormal_ear_physiology1.16527241
49MP0002254_reproductive_system_inflammat1.13611900
50MP0010030_abnormal_orbit_morphology1.13608474
51MP0008004_abnormal_stomach_pH1.12796960
52MP0006036_abnormal_mitochondrial_physio1.08876717
53MP0002557_abnormal_social/conspecific_i1.05998966
54MP0006072_abnormal_retinal_apoptosis1.05886364
55MP0005253_abnormal_eye_physiology1.05458775
56MP0001970_abnormal_pain_threshold1.01932394
57MP0003646_muscle_fatigue1.01040138
58MP0000015_abnormal_ear_pigmentation0.99571022
59MP0009046_muscle_twitch0.97867308
60MP0002572_abnormal_emotion/affect_behav0.93515995
61MP0006054_spinal_hemorrhage0.92943603
62MP0002733_abnormal_thermal_nociception0.92626698
63MP0004142_abnormal_muscle_tone0.92569174
64MP0002067_abnormal_sensory_capabilities0.90681883
65MP0003635_abnormal_synaptic_transmissio0.89997457
66MP0002928_abnormal_bile_duct0.89195749
67MP0002752_abnormal_somatic_nervous0.87943516
68MP0001324_abnormal_eye_pigmentation0.85421849
69MP0004381_abnormal_hair_follicle0.84530214
70MP0005195_abnormal_posterior_eye0.84452741
71MP0004924_abnormal_behavior0.84321705
72MP0005386_behavior/neurological_phenoty0.84321705
73MP0002095_abnormal_skin_pigmentation0.84170980
74MP0005409_darkened_coat_color0.83709913
75MP0002638_abnormal_pupillary_reflex0.81601271
76MP0003137_abnormal_impulse_conducting0.80459761
77MP0003252_abnormal_bile_duct0.80422053
78MP0002233_abnormal_nose_morphology0.79882104
79MP0005187_abnormal_penis_morphology0.78819716
80MP0002751_abnormal_autonomic_nervous0.78326440
81MP0003315_abnormal_perineum_morphology0.76422521
82MP0003186_abnormal_redox_activity0.75816650
83MP0001286_abnormal_eye_development0.74219101
84MP0005423_abnormal_somatic_nervous0.72654091
85MP0005391_vision/eye_phenotype0.71472216
86MP0003567_abnormal_fetal_cardiomyocyte0.69947526
87MP0005389_reproductive_system_phenotype0.68922661
88MP0002063_abnormal_learning/memory/cond0.68279508
89MP0000049_abnormal_middle_ear0.67806132
90MP0004019_abnormal_vitamin_homeostasis0.67496725
91MP0002210_abnormal_sex_determination0.67430883
92MP0000653_abnormal_sex_gland0.65110010
93MP0001486_abnormal_startle_reflex0.64780414
94MP0003879_abnormal_hair_cell0.64202636
95MP0001440_abnormal_grooming_behavior0.63864717
96MP0008775_abnormal_heart_ventricle0.63860086
97MP0002734_abnormal_mechanical_nocicepti0.63264810
98MP0001929_abnormal_gametogenesis0.63245648
99MP0002160_abnormal_reproductive_system0.63135931
100MP0000026_abnormal_inner_ear0.63020745

Predicted human phenotypes

RankGene SetZ-score
1Asplenia (HP:0001746)3.86721608
2Pancreatic fibrosis (HP:0100732)3.84261980
3Aplasia/Hypoplasia of the spleen (HP:0010451)3.81097029
4Supernumerary spleens (HP:0009799)3.78455875
5Abnormality of the labia minora (HP:0012880)3.57762764
6Pancreatic cysts (HP:0001737)3.44936818
7Septo-optic dysplasia (HP:0100842)3.43611024
8Abdominal situs inversus (HP:0003363)3.31778230
9Abnormality of abdominal situs (HP:0011620)3.31778230
10Reticulocytopenia (HP:0001896)3.17241285
11Acute necrotizing encephalopathy (HP:0006965)3.11242089
12Nephronophthisis (HP:0000090)3.07753847
13Molar tooth sign on MRI (HP:0002419)3.05923503
14Abnormality of midbrain morphology (HP:0002418)3.05923503
15Hypoplastic pelvis (HP:0008839)3.02856952
16Oligodactyly (hands) (HP:0001180)2.97036315
17Colon cancer (HP:0003003)2.94260794
18Acute encephalopathy (HP:0006846)2.92256171
19Methylmalonic acidemia (HP:0002912)2.89042249
20Increased hepatocellular lipid droplets (HP:0006565)2.84804568
21Bile duct proliferation (HP:0001408)2.84572339
22Abnormal biliary tract physiology (HP:0012439)2.84572339
23Abnormality of the renal medulla (HP:0100957)2.81929133
24Type II lissencephaly (HP:0007260)2.80960125
25Abolished electroretinogram (ERG) (HP:0000550)2.75839869
26Renal Fanconi syndrome (HP:0001994)2.74557400
27Methylmalonic aciduria (HP:0012120)2.71226681
28Progressive macrocephaly (HP:0004481)2.70467104
29Lipid accumulation in hepatocytes (HP:0006561)2.68200588
30Hyperglycinemia (HP:0002154)2.65904426
31Abnormality of the renal cortex (HP:0011035)2.58936513
32Increased CSF lactate (HP:0002490)2.55647535
33Abnormal mitochondria in muscle tissue (HP:0008316)2.53234597
34True hermaphroditism (HP:0010459)2.53082568
35Mitochondrial inheritance (HP:0001427)2.50723197
36Chronic hepatic failure (HP:0100626)2.45061493
37Cystic liver disease (HP:0006706)2.44962183
38Adrenal hypoplasia (HP:0000835)2.44186834
39Abnormality of DNA repair (HP:0003254)2.40364772
40Double outlet right ventricle (HP:0001719)2.38295915
41Congenital malformation of the right heart (HP:0011723)2.38295915
42Optic disc pallor (HP:0000543)2.38230134
43Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.33794796
44Optic nerve hypoplasia (HP:0000609)2.33386108
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32771712
46Abnormality of alanine metabolism (HP:0010916)2.32771712
47Hyperalaninemia (HP:0003348)2.32771712
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.27056564
49Anencephaly (HP:0002323)2.26417046
50Congenital stationary night blindness (HP:0007642)2.24037824
51Medial flaring of the eyebrow (HP:0010747)2.22085050
52Occipital encephalocele (HP:0002085)2.21139731
53Respiratory difficulties (HP:0002880)2.19571764
54Progressive inability to walk (HP:0002505)2.18608704
55Neoplasm of the adrenal cortex (HP:0100641)2.17955626
56Tubular atrophy (HP:0000092)2.17399067
57Entropion (HP:0000621)2.15602344
58Congenital hepatic fibrosis (HP:0002612)2.13264514
59Inability to walk (HP:0002540)2.08153712
60Congenital, generalized hypertrichosis (HP:0004540)2.06639426
61Oligodactyly (HP:0012165)2.03315486
62Hyperglycinuria (HP:0003108)2.02762019
63Agitation (HP:0000713)2.01322534
64Chorioretinal atrophy (HP:0000533)1.98642545
65Retinal dysplasia (HP:0007973)1.97874814
66Abnormal rod and cone electroretinograms (HP:0008323)1.97064895
67Cerebral edema (HP:0002181)1.95892046
68Aplasia/Hypoplasia of the tongue (HP:0010295)1.95767100
69Delayed CNS myelination (HP:0002188)1.94885047
70Abnormality of serine family amino acid metabolism (HP:0010894)1.94808953
71Abnormality of glycine metabolism (HP:0010895)1.94808953
72Anophthalmia (HP:0000528)1.94514748
73Genital tract atresia (HP:0001827)1.93479228
74Polydipsia (HP:0001959)1.89908983
75Abnormal drinking behavior (HP:0030082)1.89908983
76Pancreatic islet-cell hyperplasia (HP:0004510)1.89387827
77Myokymia (HP:0002411)1.89123040
78Status epilepticus (HP:0002133)1.88766143
79Sclerocornea (HP:0000647)1.88598476
80Pachygyria (HP:0001302)1.87030653
81Lissencephaly (HP:0001339)1.86618698
82Renal cortical cysts (HP:0000803)1.86457512
83Preaxial hand polydactyly (HP:0001177)1.84547531
84Pendular nystagmus (HP:0012043)1.82915035
85Exertional dyspnea (HP:0002875)1.81360533
86Polyuria (HP:0000103)1.81222127
87Postaxial foot polydactyly (HP:0001830)1.80515344
88Leukodystrophy (HP:0002415)1.80203592
893-Methylglutaconic aciduria (HP:0003535)1.77524059
90Abnormality of renal resorption (HP:0011038)1.77045577
91Abnormal lung lobation (HP:0002101)1.76982110
92Optic nerve coloboma (HP:0000588)1.76942940
93Vaginal atresia (HP:0000148)1.76568932
94Lethargy (HP:0001254)1.74700306
95Abnormal hair whorl (HP:0010721)1.74480251
96Dandy-Walker malformation (HP:0001305)1.74163756
97Labial hypoplasia (HP:0000066)1.73622442
98Abnormality of urine glucose concentration (HP:0011016)1.72208470
99Glycosuria (HP:0003076)1.72208470
100Absent septum pellucidum (HP:0001331)1.71875361

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK165.42309039
2BMPR1B3.39571911
3ACVR1B3.39445143
4TIE13.14161415
5GRK13.07830445
6ADRBK22.46217078
7WNK42.41701328
8NUAK12.26154284
9TRIM281.95298632
10EIF2AK11.95271372
11MKNK21.86951845
12FRK1.79428395
13ERBB41.77279103
14PINK11.77096114
15TNIK1.76711187
16TGFBR11.74823242
17CSNK1G11.71083712
18CSNK1G31.70387653
19CSNK1G21.66986088
20PDK21.62021984
21PLK21.49441171
22OXSR11.46418547
23CSNK1A1L1.42608048
24WNK31.39294526
25STK391.36650893
26EIF2AK31.29083425
27MAPK131.29061869
28VRK21.27557638
29BUB11.25549292
30PLK31.17952809
31BCKDK1.15813608
32ADRBK11.08507082
33DYRK21.06516932
34PRKCG1.04843446
35ZAK1.04370418
36PLK41.02775771
37NEK11.02769346
38VRK11.01131195
39PHKG11.00237985
40PHKG21.00237985
41INSRR0.96391973
42MKNK10.92053307
43NTRK20.88737913
44PRKD30.88501652
45TYRO30.88030410
46PBK0.86872596
47WNK10.81160554
48TGFBR20.79889348
49CASK0.79784172
50DAPK30.78839267
51PLK10.77299437
52PAK30.74353685
53ERBB30.73207565
54DMPK0.72776706
55CAMKK20.72735707
56PRKCQ0.70604618
57TLK10.68716838
58CDK190.68596709
59PRKCH0.68482169
60MAP3K130.63739742
61MAP2K70.63344945
62CHEK20.62753962
63PRKCE0.61266439
64EPHA40.59681894
65PIK3CA0.59290731
66BRSK10.55013494
67CLK10.54604643
68CSNK1E0.52499235
69CSNK1A10.51766779
70BRSK20.51201572
71TEC0.48767553
72LRRK20.48738663
73EIF2AK20.48530547
74ATR0.48529314
75WEE10.48226377
76MINK10.48224144
77ATM0.45549400
78EPHB20.45264777
79PRKCD0.44462136
80PRKDC0.43762775
81MST40.43264267
82FLT30.43082264
83MAPKAPK30.41674929
84NTRK10.40486032
85DAPK20.40029645
86MAP4K20.39020024
87MAP3K40.38269253
88CSNK1D0.37071773
89PRKACA0.36742669
90TAF10.36570324
91SGK10.35795130
92RPS6KB10.32933463
93STK100.32419499
94PRKACB0.32235785
95CSNK2A20.32186551
96AURKA0.31867748
97PRKCA0.30514275
98CAMK2A0.29595266
99FES0.29477522
100PIM10.28467392

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.56389298
2Oxidative phosphorylation_Homo sapiens_hsa001903.17063318
3Protein export_Homo sapiens_hsa030603.14625842
4Parkinsons disease_Homo sapiens_hsa050122.63621313
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.49716885
6Butanoate metabolism_Homo sapiens_hsa006502.47039433
7Basal transcription factors_Homo sapiens_hsa030222.36432344
8Homologous recombination_Homo sapiens_hsa034402.35740091
9Proteasome_Homo sapiens_hsa030502.27928090
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.10962946
11RNA polymerase_Homo sapiens_hsa030202.09740362
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.09731525
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.07549903
14Propanoate metabolism_Homo sapiens_hsa006401.96384840
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87472571
16RNA degradation_Homo sapiens_hsa030181.81307173
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.77984442
18Huntingtons disease_Homo sapiens_hsa050161.74489756
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74321712
20Nucleotide excision repair_Homo sapiens_hsa034201.74092658
21Cardiac muscle contraction_Homo sapiens_hsa042601.68080049
22Linoleic acid metabolism_Homo sapiens_hsa005911.67153773
23Non-homologous end-joining_Homo sapiens_hsa034501.65343790
24Alzheimers disease_Homo sapiens_hsa050101.64903667
25Tryptophan metabolism_Homo sapiens_hsa003801.62780843
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52018300
27One carbon pool by folate_Homo sapiens_hsa006701.51051990
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46284287
29Fatty acid elongation_Homo sapiens_hsa000621.45108317
30Steroid biosynthesis_Homo sapiens_hsa001001.42216708
31Nitrogen metabolism_Homo sapiens_hsa009101.41532287
32Fanconi anemia pathway_Homo sapiens_hsa034601.40725976
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40193891
34Peroxisome_Homo sapiens_hsa041461.38945027
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.38925974
36Mismatch repair_Homo sapiens_hsa034301.38596509
37Olfactory transduction_Homo sapiens_hsa047401.37286583
38Phototransduction_Homo sapiens_hsa047441.29091039
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28565932
40Ether lipid metabolism_Homo sapiens_hsa005651.12131999
41Nicotine addiction_Homo sapiens_hsa050331.11155809
42Regulation of autophagy_Homo sapiens_hsa041401.05704014
43Fatty acid metabolism_Homo sapiens_hsa012121.02166981
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.01295244
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99420904
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97657940
47Chemical carcinogenesis_Homo sapiens_hsa052040.97607465
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96037704
49Folate biosynthesis_Homo sapiens_hsa007900.95707428
50Pyruvate metabolism_Homo sapiens_hsa006200.92744999
51RNA transport_Homo sapiens_hsa030130.87274944
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86253427
53Retinol metabolism_Homo sapiens_hsa008300.84895499
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83649012
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83385273
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80811988
57Arachidonic acid metabolism_Homo sapiens_hsa005900.80201808
58Wnt signaling pathway_Homo sapiens_hsa043100.77706157
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76477450
60Fatty acid degradation_Homo sapiens_hsa000710.76067101
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.75980445
62Glutathione metabolism_Homo sapiens_hsa004800.73167309
63Metabolic pathways_Homo sapiens_hsa011000.72929373
64Pyrimidine metabolism_Homo sapiens_hsa002400.72540494
65Caffeine metabolism_Homo sapiens_hsa002320.71196386
66Insulin secretion_Homo sapiens_hsa049110.70399373
67Basal cell carcinoma_Homo sapiens_hsa052170.68799161
68Ovarian steroidogenesis_Homo sapiens_hsa049130.66165856
69Purine metabolism_Homo sapiens_hsa002300.65852933
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.65415036
71Fat digestion and absorption_Homo sapiens_hsa049750.60967701
72Serotonergic synapse_Homo sapiens_hsa047260.59926587
73Collecting duct acid secretion_Homo sapiens_hsa049660.59778498
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55606681
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55012854
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54565520
77Taste transduction_Homo sapiens_hsa047420.54036501
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53263219
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.53118087
80DNA replication_Homo sapiens_hsa030300.51103946
81Vitamin digestion and absorption_Homo sapiens_hsa049770.50256277
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49267750
83Hedgehog signaling pathway_Homo sapiens_hsa043400.46809562
84Glutamatergic synapse_Homo sapiens_hsa047240.45469376
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40833441
86Sulfur relay system_Homo sapiens_hsa041220.40682832
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38516939
88Oxytocin signaling pathway_Homo sapiens_hsa049210.38395475
89Fatty acid biosynthesis_Homo sapiens_hsa000610.37992150
90Morphine addiction_Homo sapiens_hsa050320.37524860
91Calcium signaling pathway_Homo sapiens_hsa040200.35134124
92Base excision repair_Homo sapiens_hsa034100.34340321
93ABC transporters_Homo sapiens_hsa020100.33743498
94GABAergic synapse_Homo sapiens_hsa047270.33663978
95p53 signaling pathway_Homo sapiens_hsa041150.33387354
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.31267345
97Selenocompound metabolism_Homo sapiens_hsa004500.31135347
98Tyrosine metabolism_Homo sapiens_hsa003500.30652806
99Arginine and proline metabolism_Homo sapiens_hsa003300.29372753
100Cell cycle_Homo sapiens_hsa041100.28873269

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