UBC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.85777299
2microglial cell activation (GO:0001774)4.90481561
3regulation of interleukin-12 biosynthetic process (GO:0045075)4.28492477
4purinergic nucleotide receptor signaling pathway (GO:0035590)4.04175593
5macrophage activation (GO:0042116)3.86678341
6response to muramyl dipeptide (GO:0032495)3.82679936
7regulation of dendritic cell antigen processing and presentation (GO:0002604)3.82121900
8G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.81436248
9antigen processing and presentation of endogenous antigen (GO:0019883)3.68482494
10protein localization to endosome (GO:0036010)3.67109083
11cellular extravasation (GO:0045123)3.64786648
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.56320686
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.56320686
14positive regulation of antigen processing and presentation (GO:0002579)3.53489570
15positive regulation of cellular amide metabolic process (GO:0034250)3.50114465
16macrophage activation involved in immune response (GO:0002281)3.45453769
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.42474626
18response to laminar fluid shear stress (GO:0034616)3.37088782
19adenosine receptor signaling pathway (GO:0001973)3.28594855
20retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.28005593
21negative regulation of granulocyte differentiation (GO:0030853)3.26722238
22negative regulation of bone resorption (GO:0045779)3.23138545
23NIK/NF-kappaB signaling (GO:0038061)3.17671765
24barbed-end actin filament capping (GO:0051016)3.15356143
25purinergic receptor signaling pathway (GO:0035587)3.14379887
26hepatocyte apoptotic process (GO:0097284)3.13540873
27interleukin-1-mediated signaling pathway (GO:0070498)3.12551527
28regulation of antigen processing and presentation (GO:0002577)3.07803195
29regulation of T-helper 2 cell differentiation (GO:0045628)3.05729946
30activation of MAPKKK activity (GO:0000185)3.02547391
31regulation of B cell receptor signaling pathway (GO:0050855)3.01376575
32COPI coating of Golgi vesicle (GO:0048205)2.93381543
33Golgi transport vesicle coating (GO:0048200)2.93381543
34chaperone mediated protein folding requiring cofactor (GO:0051085)2.92476924
35activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.89925307
36response to fluid shear stress (GO:0034405)2.89381952
37response to peptidoglycan (GO:0032494)2.87786125
38interferon-gamma-mediated signaling pathway (GO:0060333)2.84423692
39negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.83971112
40keratan sulfate catabolic process (GO:0042340)2.81363243
41cellular response to fluid shear stress (GO:0071498)2.81219809
42type I interferon signaling pathway (GO:0060337)2.80689128
43cellular response to type I interferon (GO:0071357)2.80689128
44response to type I interferon (GO:0034340)2.79535960
45negative regulation of cell killing (GO:0031342)2.76833409
46negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.76833409
47vascular endothelial growth factor signaling pathway (GO:0038084)2.75932116
48phagocytosis, engulfment (GO:0006911)2.75196904
49positive regulation of monocyte chemotaxis (GO:0090026)2.72289516
50response to progesterone (GO:0032570)2.71627627
51skin morphogenesis (GO:0043589)2.70971588
52positive regulation of nuclease activity (GO:0032075)2.69417843
53positive regulation of gamma-delta T cell activation (GO:0046645)2.68770164
54endoplasmic reticulum unfolded protein response (GO:0030968)2.68597779
55glycosphingolipid catabolic process (GO:0046479)2.67049936
56negative regulation of norepinephrine secretion (GO:0010700)2.66958975
57T cell migration (GO:0072678)2.66077972
58negative regulation of mast cell activation (GO:0033004)2.65852603
59maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.65769645
60regulation of interferon-beta biosynthetic process (GO:0045357)2.65694893
61cellular response to antibiotic (GO:0071236)2.64423975
62detection of other organism (GO:0098543)2.63857415
63positive regulation of interferon-alpha production (GO:0032727)2.63840021
64tolerance induction (GO:0002507)2.62555761
65growth hormone receptor signaling pathway (GO:0060396)2.61166650
66negative regulation of bone remodeling (GO:0046851)2.60874949
67myeloid leukocyte activation (GO:0002274)2.59637506
68vesicle coating (GO:0006901)2.58562019
69positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.58232841
70definitive hemopoiesis (GO:0060216)2.57804595
71cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.56701305
72endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.55895620
73macroautophagy (GO:0016236)2.55031602
74negative regulation of erythrocyte differentiation (GO:0045647)2.54287040
75regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.53724052
76cellular response to unfolded protein (GO:0034620)2.53504207
77negative regulation of tissue remodeling (GO:0034104)2.53120007
78regulation of interferon-alpha production (GO:0032647)2.52742194
79mast cell activation (GO:0045576)2.51234908
80regulation of monocyte chemotaxis (GO:0090025)2.50097060
81* nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.49151525
82detection of molecule of bacterial origin (GO:0032490)2.48921421
83dendritic cell chemotaxis (GO:0002407)2.48736492
84regulation of response to interferon-gamma (GO:0060330)2.48415923
85positive regulation by symbiont of host defense response (GO:0052509)2.48408680
86modulation by symbiont of host defense response (GO:0052031)2.48408680
87modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.48408680
88modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.48408680
89positive regulation by organism of defense response of other organism involved in symbiotic interact2.48408680
90modulation by symbiont of host immune response (GO:0052553)2.48408680
91glucose 6-phosphate metabolic process (GO:0051156)2.47848272
92regulation of nuclease activity (GO:0032069)2.47344458
93stress fiber assembly (GO:0043149)2.47115719
94ER-nucleus signaling pathway (GO:0006984)2.47035736
95negative regulation of glycoprotein biosynthetic process (GO:0010561)2.45651612
96cell proliferation involved in kidney development (GO:0072111)2.45378492
97myeloid cell activation involved in immune response (GO:0002275)2.44017322
98regulation of podosome assembly (GO:0071801)2.43671294
99JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.43166243
100embryonic process involved in female pregnancy (GO:0060136)2.42812063
101regulation of defense response to virus by virus (GO:0050690)2.41894998
102membrane raft organization (GO:0031579)2.41432142
103regulation of extracellular matrix disassembly (GO:0010715)2.40862781
104regulation of cellular extravasation (GO:0002691)2.40092616
105peptide catabolic process (GO:0043171)2.39763786
106sprouting angiogenesis (GO:0002040)2.39590086
107positive regulation of type 2 immune response (GO:0002830)2.39101630
108activation of Rac GTPase activity (GO:0032863)2.38908035
109detection of bacterium (GO:0016045)2.38337117
110phagocytosis, recognition (GO:0006910)2.37350214
111lipopolysaccharide-mediated signaling pathway (GO:0031663)2.37340139
112dendritic cell migration (GO:0036336)2.37290815
113negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.35933748
114sexual reproduction (GO:0019953)2.34943517
115regulation of protein import into nucleus, translocation (GO:0033158)2.34906698
116establishment of endothelial barrier (GO:0061028)2.34831076
117germinal center formation (GO:0002467)2.33343612
118glycolipid catabolic process (GO:0019377)2.33314233
119immunoglobulin mediated immune response (GO:0016064)2.32999498
120positive regulation of chemokine secretion (GO:0090197)2.32585615
121adhesion of symbiont to host (GO:0044406)2.32519703
122mannose metabolic process (GO:0006013)2.32334524
123histamine secretion (GO:0001821)2.32168082
124lipoxygenase pathway (GO:0019372)2.31990592
125detection of external biotic stimulus (GO:0098581)2.31685107
126positive regulation of p38MAPK cascade (GO:1900745)2.30820028
127cellular response to topologically incorrect protein (GO:0035967)2.30689658
128negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.30641985
129regulation of chemokine secretion (GO:0090196)2.28574479
130positive regulation of cholesterol efflux (GO:0010875)2.28118095
131positive regulation of interferon-beta production (GO:0032728)2.27791924
132negative regulation of necroptotic process (GO:0060546)2.27706977
133amyloid precursor protein catabolic process (GO:0042987)2.26062645
134neutrophil activation involved in immune response (GO:0002283)2.25226923
135positive regulation of extracellular matrix organization (GO:1903055)2.25218078
136regulation of necroptotic process (GO:0060544)2.22835844
137signal complex assembly (GO:0007172)2.21692541
138regulation of type 2 immune response (GO:0002828)2.20279171
139ER overload response (GO:0006983)2.19221015
140regulation of type I interferon-mediated signaling pathway (GO:0060338)2.14189561
141negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.13403306
142regulation of ARF protein signal transduction (GO:0032012)2.13050873
143cytoskeletal anchoring at plasma membrane (GO:0007016)2.11800194
144amyloid precursor protein metabolic process (GO:0042982)2.11292336
145negative regulation of glycoprotein metabolic process (GO:1903019)2.09262824
146protein hydroxylation (GO:0018126)2.07856103
147response to unfolded protein (GO:0006986)2.07034245
148dosage compensation (GO:0007549)2.04926811
149response to endoplasmic reticulum stress (GO:0034976)2.04825008
150regulation of leukocyte degranulation (GO:0043300)2.04039057
151immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.03475499
152Fc-gamma receptor signaling pathway (GO:0038094)2.03475499
153Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.03475499
154Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.02108857
155negative regulation of innate immune response (GO:0045824)2.01979614
156negative regulation of necrotic cell death (GO:0060547)2.01133084
157intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.01105926
158positive regulation of Cdc42 GTPase activity (GO:0043089)2.01022070
159positive regulation of receptor recycling (GO:0001921)2.00724587
160regulation of amyloid precursor protein catabolic process (GO:1902991)2.00101991
161cell adhesion mediated by integrin (GO:0033627)1.99334514
162positive regulation of protein homooligomerization (GO:0032464)1.99324307
163Arp2/3 complex-mediated actin nucleation (GO:0034314)1.98296924

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.50142522
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.78813732
3* IRF8_22096565_ChIP-ChIP_GC-B_Human3.78244301
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.56147358
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.45809995
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.29033247
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.15899635
8IRF8_27001747_Chip-Seq_BMDM_Mouse2.76200481
9RUNX_20019798_ChIP-Seq_JUKART_Human2.74823444
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.72491479
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.69661135
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.65460184
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.62373161
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.61294308
15GATA2_21666600_ChIP-Seq_HMVEC_Human2.60057539
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.59733904
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43415544
18GATA1_22025678_ChIP-Seq_K562_Human2.43021042
19SCL_19346495_ChIP-Seq_HPC-7_Human2.29328580
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.18459929
21* CLOCK_20551151_ChIP-Seq_293T_Human2.18003877
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.11149611
23* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.09490539
24RARG_19884340_ChIP-ChIP_MEFs_Mouse2.09285859
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.06329028
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.04745209
27* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.02345420
28* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.93495345
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.92349221
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.89265617
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.81332305
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.80088935
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.72782631
34* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72078588
35* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71409074
36* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68054665
37* RACK7_27058665_Chip-Seq_MCF-7_Human1.67699353
38LXR_22292898_ChIP-Seq_THP-1_Human1.67272341
39KDM2B_26808549_Chip-Seq_DND41_Human1.65309745
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61399344
41* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60867896
42PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.59897079
43VDR_21846776_ChIP-Seq_THP-1_Human1.59694463
44KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.56810478
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53317348
46* ATF3_27146783_Chip-Seq_COLON_Human1.51217279
47* MYB_26560356_Chip-Seq_TH2_Human1.50386683
48ZNF263_19887448_ChIP-Seq_K562_Human1.50345874
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.47208286
50MYC_22102868_ChIP-Seq_BL_Human1.46361064
51VDR_24787735_ChIP-Seq_THP-1_Human1.45456718
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.44322374
53* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.39446232
54* CJUN_26792858_Chip-Seq_BT549_Human1.39403778
55WT1_19549856_ChIP-ChIP_CCG9911_Human1.38372533
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38241587
57* KDM2B_26808549_Chip-Seq_K562_Human1.37254088
58ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36486180
59* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36415306
60* MAF_26560356_Chip-Seq_TH1_Human1.36290660
61SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34478161
62PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34098767
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32130674
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31906102
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31487202
66* RUNX1_22412390_ChIP-Seq_EML_Mouse1.31350712
67* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.31178716
68ESR1_20079471_ChIP-ChIP_T-47D_Human1.30423594
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30012136
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.29044556
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28077457
72* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27796402
73* MYB_26560356_Chip-Seq_TH1_Human1.27162823
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.26623005
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25470126
76* TCF7_22412390_ChIP-Seq_EML_Mouse1.25084146
77* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25061974
78* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24948238
79* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.23685553
80* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23602655
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22708427
82SPI1_23127762_ChIP-Seq_K562_Human1.21685219
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20964738
84* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20060099
85* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20060099
86SMAD_19615063_ChIP-ChIP_OVARY_Human1.18928527
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18446742
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18031453
89FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.16070863
90TFEB_21752829_ChIP-Seq_HELA_Human1.15857809
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14917038
92NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14159213
93* ELK3_25401928_ChIP-Seq_HUVEC_Human1.13773682
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13484283
95GATA3_27048872_Chip-Seq_THYMUS_Human1.12238802
96* VDR_24763502_ChIP-Seq_THP-1_Human1.11150888
97* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10370649
98PU_27001747_Chip-Seq_BMDM_Mouse1.08863800
99GATA2_19941826_ChIP-Seq_K562_Human1.08091617
100GATA1_19941827_ChIP-Seq_MEL_Mouse1.08083528
101GATA1_19941826_ChIP-Seq_K562_Human1.07994357
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07042761
103* KDM2B_26808549_Chip-Seq_JURKAT_Human1.07006325
104CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07000440
105* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06696680
106CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06642998
107* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06497701
108MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06139354
109* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06012381
110TP53_22127205_ChIP-Seq_IMR90_Human1.05599383
111GATA3_26560356_Chip-Seq_TH2_Human1.05513890
112ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04998627
113CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04356753
114* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04227930
115* SPI1_23547873_ChIP-Seq_NB4_Human1.03825395
116* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03459968
117* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03147069
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02782403
119* RUNX1_27514584_Chip-Seq_MCF-7_Human1.02537994
120* MAF_26560356_Chip-Seq_TH2_Human1.02101338
121P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01956338
122ESR2_21235772_ChIP-Seq_MCF-7_Human1.01874196
123* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01506199
124FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00772095
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00347385
126NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98710088
127PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98019750
128* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97624135
129TBX20_22328084_ChIP-Seq_HEART_Mouse0.96968823
130* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96046003
131GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94220333
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92021941
133* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91651995
134EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90696185
135SOX2_20726797_ChIP-Seq_SW620_Human0.90476472
136* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89799551
137* UTX_26944678_Chip-Seq_JUKART_Human0.88908176
138FOXO3_23340844_ChIP-Seq_DLD1_Human0.87020525
139BRD4_25478319_ChIP-Seq_HGPS_Human0.85867896
140CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85500216
141CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83354024

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.41438289
2MP0008260_abnormal_autophagy3.33634201
3MP0001835_abnormal_antigen_presentation3.24346369
4MP0003329_amyloid_beta_deposits2.82377575
5MP0002877_abnormal_melanocyte_morpholog2.66495865
6MP0005058_abnormal_lysosome_morphology2.56062294
7MP0005671_abnormal_response_to2.51509540
8MP0006082_CNS_inflammation2.44817596
9MP0003191_abnormal_cellular_cholesterol2.40594864
10MP0010234_abnormal_vibrissa_follicle2.38466973
11MP0003279_aneurysm2.31363754
12MP0002148_abnormal_hypersensitivity_rea2.25388167
13MP0003436_decreased_susceptibility_to2.25313288
14MP0009278_abnormal_bone_marrow2.24749069
15MP0009785_altered_susceptibility_to2.21100422
16MP0010368_abnormal_lymphatic_system2.17975026
17MP0001873_stomach_inflammation2.17620999
18MP0002419_abnormal_innate_immunity2.15361733
19MP0000604_amyloidosis2.02835908
20MP0005000_abnormal_immune_tolerance1.99742131
21MP0008438_abnormal_cutaneous_collagen1.97947211
22MP0002452_abnormal_antigen_presenting1.97188030
23MP0005387_immune_system_phenotype1.96416111
24MP0001790_abnormal_immune_system1.96416111
25MP0001533_abnormal_skeleton_physiology1.94997961
26MP0003300_gastrointestinal_ulcer1.93503974
27MP0003828_pulmonary_edema1.88179329
28MP0004883_abnormal_blood_vessel1.86239454
29MP0000685_abnormal_immune_system1.83282169
30MP0005464_abnormal_platelet_physiology1.82118330
31MP0001800_abnormal_humoral_immune1.80414436
32MP0002405_respiratory_system_inflammati1.75411492
33MP0002723_abnormal_immune_serum1.71648912
34MP0003453_abnormal_keratinocyte_physiol1.71530833
35MP0005670_abnormal_white_adipose1.71093291
36MP0002420_abnormal_adaptive_immunity1.66172513
37MP0001819_abnormal_immune_cell1.65578719
38MP0003690_abnormal_glial_cell1.65322194
39MP0003763_abnormal_thymus_physiology1.60425319
40MP0002254_reproductive_system_inflammat1.60349216
41MP0004808_abnormal_hematopoietic_stem1.55460929
42MP0005451_abnormal_body_composition1.54735263
43MP0005025_abnormal_response_to1.52208518
44MP0002998_abnormal_bone_remodeling1.51383123
45MP0003656_abnormal_erythrocyte_physiolo1.50865023
46MP0002933_joint_inflammation1.50309019
47MP0001879_abnormal_lymphatic_vessel1.49106622
48MP0005503_abnormal_tendon_morphology1.48284035
49MP0005397_hematopoietic_system_phenotyp1.46129981
50MP0001545_abnormal_hematopoietic_system1.46129981
51MP0003183_abnormal_peptide_metabolism1.45556252
52MP0000343_altered_response_to1.44218433
53MP0003075_altered_response_to1.43201466
54MP0003045_fibrosis1.41960801
55MP0000249_abnormal_blood_vessel1.41722356
56MP0005410_abnormal_fertilization1.40100585
57MP0006054_spinal_hemorrhage1.39430624
58MP0002166_altered_tumor_susceptibility1.38732510
59MP0001542_abnormal_bone_strength1.38023557
60MP0010155_abnormal_intestine_physiology1.36250694
61MP0004947_skin_inflammation1.35767986
62MP0009333_abnormal_splenocyte_physiolog1.33159672
63MP0004264_abnormal_extraembryonic_tissu1.32227627
64MP0005164_abnormal_response_to1.31390159
65MP0001845_abnormal_inflammatory_respons1.30247848
66MP0000767_abnormal_smooth_muscle1.27098505
67MP0005390_skeleton_phenotype1.24006944
68MP0005167_abnormal_blood-brain_barrier1.22839764
69* MP0008007_abnormal_cellular_replicative1.22180673
70MP0003795_abnormal_bone_structure1.21857373
71MP0000920_abnormal_myelination1.17001648
72MP0001348_abnormal_lacrimal_gland1.16989348
73MP0005023_abnormal_wound_healing1.15632934
74MP0009840_abnormal_foam_cell1.15610239
75MP0000858_altered_metastatic_potential1.14283423
76MP0001851_eye_inflammation1.13903281
77MP0001853_heart_inflammation1.12858977
78MP0003705_abnormal_hypodermis_morpholog1.12842059
79MP0002132_abnormal_respiratory_system1.10395207
80MP0003221_abnormal_cardiomyocyte_apopto1.10259336
81MP0005165_increased_susceptibility_to1.09798592
82MP0003172_abnormal_lysosome_physiology1.09704206
83MP0000013_abnormal_adipose_tissue1.09305087
84MP0004859_abnormal_synaptic_plasticity1.08805041
85MP0000716_abnormal_immune_system1.08574859
86MP0002398_abnormal_bone_marrow1.08457620
87MP0003091_abnormal_cell_migration1.07036870
88MP0003303_peritoneal_inflammation1.06518216
89MP0001216_abnormal_epidermal_layer1.06511215
90MP0003950_abnormal_plasma_membrane1.06386036
91MP0004147_increased_porphyrin_level1.05601023
92* MP0003943_abnormal_hepatobiliary_system1.04538813
93MP0005166_decreased_susceptibility_to1.03769196
94MP0002332_abnormal_exercise_endurance1.03505331
95MP0002928_abnormal_bile_duct1.02677921
96MP0003448_altered_tumor_morphology1.01388996
97MP0002138_abnormal_hepatobiliary_system1.01343430
98MP0003634_abnormal_glial_cell1.00793860
99MP0004510_myositis0.99963051
100MP0008469_abnormal_protein_level0.99886686
101MP0005621_abnormal_cell_physiology0.99004143
102MP0005076_abnormal_cell_differentiation0.98719442
103MP0005310_abnormal_salivary_gland0.98462388
104MP0008874_decreased_physiological_sensi0.98409764
105MP0002796_impaired_skin_barrier0.97585765
106MP0010307_abnormal_tumor_latency0.97476732
107MP0001849_ear_inflammation0.96154892
108MP0000689_abnormal_spleen_morphology0.95158687
109MP0003566_abnormal_cell_adhesion0.92473783
110MP0000003_abnormal_adipose_tissue0.92085588
111MP0002006_tumorigenesis0.91891239
112* MP0002429_abnormal_blood_cell0.89962985
113MP0008961_abnormal_basal_metabolism0.88598581
114MP0009697_abnormal_copulation0.88342541
115MP0005646_abnormal_pituitary_gland0.88209994
116MP0000465_gastrointestinal_hemorrhage0.87953082
117MP0005409_darkened_coat_color0.87897859
118MP0002722_abnormal_immune_system0.87765666
119MP0005375_adipose_tissue_phenotype0.87754461
120MP0001243_abnormal_dermal_layer0.87218703
121MP0002396_abnormal_hematopoietic_system0.86428073
122MP0009764_decreased_sensitivity_to0.85241184
123MP0002009_preneoplasia0.85219069
124MP0001502_abnormal_circadian_rhythm0.83953943
125MP0004782_abnormal_surfactant_physiolog0.82969264
126MP0001915_intracranial_hemorrhage0.82693938
127MP0002060_abnormal_skin_morphology0.81007227
128MP0005275_abnormal_skin_tensile0.79587279
129MP0010352_gastrointestinal_tract_polyps0.78527065
130MP0005501_abnormal_skin_physiology0.75565976
131MP0001501_abnormal_sleep_pattern0.74996281
132MP0003866_abnormal_defecation0.71590968

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)5.09919993
2Glomerulonephritis (HP:0000099)3.99642417
3Neurofibrillary tangles (HP:0002185)3.64569496
4Prostate neoplasm (HP:0100787)3.52873911
5Myositis (HP:0100614)3.48619061
6Orchitis (HP:0100796)3.46625130
7Increased neuronal autofluorescent lipopigment (HP:0002074)3.43936176
8Eczematoid dermatitis (HP:0000976)3.25560594
9Increased cerebral lipofuscin (HP:0011813)3.24477018
10Supranuclear gaze palsy (HP:0000605)3.24187825
11Dysostosis multiplex (HP:0000943)3.21819051
12Vacuolated lymphocytes (HP:0001922)3.17176761
13Arterial tortuosity (HP:0005116)3.13176388
14Vascular tortuosity (HP:0004948)3.10966736
15Loss of speech (HP:0002371)3.10927160
16Cervical subluxation (HP:0003308)3.06691565
17Abnormality of macrophages (HP:0004311)3.04392321
18Cerebral inclusion bodies (HP:0100314)3.02576161
19Retrobulbar optic neuritis (HP:0100654)3.01702366
20Optic neuritis (HP:0100653)3.01702366
21Abnormality of liposaccharide metabolism (HP:0010968)3.00177505
22Abnormality of glycosphingolipid metabolism (HP:0004343)3.00177505
23Abnormality of glycolipid metabolism (HP:0010969)3.00177505
24Complement deficiency (HP:0004431)2.98902591
25Stomach cancer (HP:0012126)2.91878695
26Abnormal gallbladder physiology (HP:0012438)2.83562820
27Cholecystitis (HP:0001082)2.83562820
28Chronic diarrhea (HP:0002028)2.80879409
29Spinal rigidity (HP:0003306)2.76289791
30Neuronal loss in central nervous system (HP:0002529)2.73350378
31Recurrent abscess formation (HP:0002722)2.68638998
32Growth hormone excess (HP:0000845)2.67465199
33Upper limb amyotrophy (HP:0009129)2.66881696
34Distal upper limb amyotrophy (HP:0007149)2.66881696
35Abnormality of complement system (HP:0005339)2.66277259
36Elevated erythrocyte sedimentation rate (HP:0003565)2.64614068
37Mucopolysacchariduria (HP:0008155)2.63158089
38Urinary glycosaminoglycan excretion (HP:0003541)2.63158089
39Colitis (HP:0002583)2.63120530
40Nuclear cataract (HP:0100018)2.61411428
41Amyloidosis (HP:0011034)2.61308102
42Apathy (HP:0000741)2.59467494
43Aortic aneurysm (HP:0004942)2.57689680
44Cellulitis (HP:0100658)2.54677130
45Urethral obstruction (HP:0000796)2.54097560
46Abnormality of mucopolysaccharide metabolism (HP:0011020)2.48726268
47Abnormality of polysaccharide metabolism (HP:0011012)2.48726268
48Abnormality of glycosaminoglycan metabolism (HP:0004371)2.48726268
49Diminished motivation (HP:0000745)2.47513441
50Hematochezia (HP:0002573)2.41374865
51Distal lower limb muscle weakness (HP:0009053)2.39776519
52Distal lower limb amyotrophy (HP:0008944)2.39508140
53Spontaneous hematomas (HP:0007420)2.38469827
54Alveolar cell carcinoma (HP:0006519)2.38057865
55Recurrent bacterial skin infections (HP:0005406)2.33842834
56Petechiae (HP:0000967)2.31683957
57Nephritis (HP:0000123)2.31617513
58Abnormal platelet function (HP:0011869)2.30528164
59Impaired platelet aggregation (HP:0003540)2.30528164
60Ankle clonus (HP:0011448)2.29304119
61Tetraparesis (HP:0002273)2.28581058
62Arterial thrombosis (HP:0004420)2.25853662
63Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.25847467
64Pulmonary infiltrates (HP:0002113)2.24828231
65Rapidly progressive (HP:0003678)2.21357737
66Alopecia of scalp (HP:0002293)2.20712691
67Nonimmune hydrops fetalis (HP:0001790)2.20518684
68Aortic dissection (HP:0002647)2.20325518
69Cerebral aneurysm (HP:0004944)2.20242352
70Broad face (HP:0000283)2.18821739
71Vertebral compression fractures (HP:0002953)2.18812557
72Keratoconjunctivitis sicca (HP:0001097)2.15078309
73Mediastinal lymphadenopathy (HP:0100721)2.14947750
74Inflammation of the large intestine (HP:0002037)2.14023074
75Spondylolisthesis (HP:0003302)2.12486282
76Neoplasm of the tracheobronchial system (HP:0100552)2.11939355
77Osteolytic defects of the hand bones (HP:0009699)2.06704177
78Osteolytic defects of the phalanges of the hand (HP:0009771)2.06704177
79Joint stiffness (HP:0001387)2.05238974
80Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.03644798
81Follicular hyperkeratosis (HP:0007502)2.03338524
82Keratoconjunctivitis (HP:0001096)2.02304644
83Mitral stenosis (HP:0001718)2.02125792
84Gastrointestinal inflammation (HP:0004386)2.02018687
85Axonal loss (HP:0003447)2.01855266
86Premature rupture of membranes (HP:0001788)2.00501527
87Protrusio acetabuli (HP:0003179)1.96977913
88Progressive visual loss (HP:0000529)1.96299938
89Osteomyelitis (HP:0002754)1.96067663
90Thick nail (HP:0001805)1.95974862
91Hypokinesia (HP:0002375)1.95449572
92Slow saccadic eye movements (HP:0000514)1.94587430
93Fatigue (HP:0012378)1.94145096
94Mutism (HP:0002300)1.92648383
95Subacute progressive viral hepatitis (HP:0006572)1.92286239
96Facial diplegia (HP:0001349)1.92137245
97Interstitial pulmonary disease (HP:0006530)1.91955908
98Distal sensory impairment (HP:0002936)1.91584665
99Difficulty climbing stairs (HP:0003551)1.89843035
100Recurrent fungal infections (HP:0002841)1.89049377
101Glucose intolerance (HP:0000833)1.88813758
102Hyperparathyroidism (HP:0000843)1.88734323
103Increased IgE level (HP:0003212)1.87509760
104Malnutrition (HP:0004395)1.87438962
105Upper limb muscle weakness (HP:0003484)1.87196366
106Increased CSF protein (HP:0002922)1.87094330
107Global brain atrophy (HP:0002283)1.85733788
108Metaphyseal cupping (HP:0003021)1.84740168
109Decreased motor nerve conduction velocity (HP:0003431)1.84479745
110Hypercortisolism (HP:0001578)1.84308735
111Abnormality of the nasal mucosa (HP:0000433)1.83164582
112Persistence of primary teeth (HP:0006335)1.82819461
113Panhypogammaglobulinemia (HP:0003139)1.81923205
114Foot dorsiflexor weakness (HP:0009027)1.81649949
115Abnormality of the intrinsic pathway (HP:0010989)1.80996275
116Hypoplasia of the odontoid process (HP:0003311)1.80657882
117Epistaxis (HP:0000421)1.80006475
118Increased connective tissue (HP:0009025)1.79741053
119Spinal muscular atrophy (HP:0007269)1.78860196
120Micronodular cirrhosis (HP:0001413)1.78600975
121Centrally nucleated skeletal muscle fibers (HP:0003687)1.77978887
122Lower limb amyotrophy (HP:0007210)1.76936640
123Erythema (HP:0010783)1.76815372
124Gingivitis (HP:0000230)1.76620425
125Glomerulopathy (HP:0100820)1.76279977
126Aortic valve stenosis (HP:0001650)1.75661632
127Hammertoe (HP:0001765)1.75067935
128IgA deficiency (HP:0002720)1.75051170
129J-shaped sella turcica (HP:0002680)1.73489666
130Short nail (HP:0001799)1.71814213
131Coarse hair (HP:0002208)1.71259869
132Agammaglobulinemia (HP:0004432)1.70217599
133Ovoid vertebral bodies (HP:0003300)1.69895908
134Vasculitis (HP:0002633)1.69063704
135Hypoglycemic seizures (HP:0002173)1.68285436
136Abnormal glucose tolerance (HP:0001952)1.67002250
137Insulin resistance (HP:0000855)1.66950750
138Bruising susceptibility (HP:0000978)1.66371270
139Myocardial infarction (HP:0001658)1.66017052
140Abnormality of the prostate (HP:0008775)1.65626233
141Segmental peripheral demyelination/remyelination (HP:0003481)1.65569700
142Hyperacusis (HP:0010780)1.64852467
143Striae distensae (HP:0001065)1.64170634
144Peripheral hypomyelination (HP:0007182)1.63034423
145Long palpebral fissure (HP:0000637)1.62779369
146Recurrent bronchitis (HP:0002837)1.62057150
147Biconcave vertebral bodies (HP:0004586)1.61544746
148Abnormality of the odontoid process (HP:0003310)1.61074180
149Symptomatic seizures (HP:0011145)1.60224072
150Recurrent viral infections (HP:0004429)1.60015170
151Hand muscle atrophy (HP:0009130)1.59865249
152Spastic gait (HP:0002064)1.59356313
153Bone pain (HP:0002653)1.56683364
154Progressive neurologic deterioration (HP:0002344)1.56039756
155Recurrent gram-negative bacterial infections (HP:0005420)1.55813073
156Personality changes (HP:0000751)1.54900706
157Depression (HP:0000716)1.54015726
158Dilatation of the ascending aorta (HP:0005111)1.53929456
159Urticaria (HP:0001025)1.52879947

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.02840482
2TGFBR23.90095129
3TSSK63.36149738
4MAPK153.35493631
5MAP3K143.33555707
6PDK23.06562782
7IRAK32.63509617
8TYK22.47723071
9PIK3CG2.26013538
10TBK12.13973632
11MAPK71.93663035
12MST1R1.86085461
13ERN11.84830189
14TXK1.82925209
15GRK71.80597983
16IKBKB1.79377911
17MAP4K11.77619989
18INSRR1.76850450
19RIPK11.75050953
20JAK11.70465735
21EPHB11.69223904
22FGFR41.67972715
23CHUK1.64931479
24EPHA31.62739130
25MAP2K21.62589696
26NEK91.62283214
27PIM21.60031976
28KIT1.54589263
29IKBKE1.50033676
30TEC1.45184975
31STK101.44642328
32KSR21.38631327
33NLK1.36041983
34MAP3K111.33820663
35IRAK41.30695052
36MAP3K11.27033502
37TESK11.26187588
38TESK21.25731296
39RIPK41.24445908
40MAP3K131.23519695
41SIK11.22691020
42KSR11.21516325
43ZAP701.18464151
44TAOK21.16558863
45ARAF1.14826681
46CSF1R1.13705523
47FES1.13574215
48JAK31.13136437
49PAK61.12053344
50ICK1.08561222
51MAP3K121.07732213
52TGFBR11.06949908
53NEK61.06054324
54CDK81.05530542
55ITK1.05296091
56PTK21.04039798
57TRIM281.03731412
58MAP3K31.03362377
59FLT31.01973352
60EPHA21.01372350
61MAP3K20.98276255
62CLK10.96482373
63STK380.94843967
64MOS0.88720360
65SIK20.88557897
66PDPK10.88505450
67TAOK10.87959358
68PTK60.86450831
69KDR0.85988280
70SIK30.85586732
71MST40.85579916
72LATS20.85330350
73MARK20.84915806
74FRK0.84719857
75BLK0.84159572
76MET0.83835805
77FGFR30.81889532
78TRIB30.81317260
79NTRK10.78283418
80PTK2B0.77519927
81MAP3K90.75992246
82LIMK10.74806387
83RAF10.74684973
84CAMK1D0.74486534
85BCR0.73516274
86MAP2K30.73269467
87LMTK20.72779520
88PAK40.69724829
89PRKG20.68302825
90BMPR1B0.66262274
91PDGFRA0.66090153
92PRKD30.65887893
93MAPK110.65423185
94BTK0.64838531
95TRPM70.63743412
96PRKD20.63629213
97BMX0.63592338
98ZAK0.63551787
99MAP3K60.62122969
100CSK0.61491529
101FGR0.61241751
102IRAK10.61238601
103PASK0.60486407
104PIM10.60449512
105MATK0.60222210
106SCYL20.58312763
107EIF2AK20.57884293
108SGK20.57879536
109GRK10.57732478
110MAP3K50.57480581
111BMPR20.57362740
112RPS6KA20.57023759
113SGK30.56708028
114MAPKAPK20.56308227
115MAPK120.56178249
116RET0.55695728
117ROCK20.55370061
118PKN20.55270045
119LCK0.54876567
120VRK10.54708010
121IRAK20.53278157
122MTOR0.53201132
123JAK20.52528339
124RPS6KA60.51606613
125HCK0.51384506
126LRRK20.50399952
127DYRK1B0.49312751
128TTN0.47866847
129CDK60.46162699
130IGF1R0.45987123
131RPS6KC10.45764931
132RPS6KL10.45764931
133PDGFRB0.44968427
134MAPKAPK50.44341952
135ERBB40.43450421
136TAOK30.43068354
137NME20.43051035
138EEF2K0.42993865
139MAP3K100.38973138
140LYN0.38462494
141PRKD10.37695560
142FYN0.37197229
143ERBB30.35481275
144PRPF4B0.34855862
145MAPKAPK30.32594936
146INSR0.32156473
147MAPK30.31756388
148PDK10.30502459
149PDK40.29766513
150PDK30.29766513
151FER0.28995694

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005312.88571740
2Other glycan degradation_Homo sapiens_hsa005112.40383463
3Leishmaniasis_Homo sapiens_hsa051402.33803727
4Osteoclast differentiation_Homo sapiens_hsa043802.27236081
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.27193704
6Legionellosis_Homo sapiens_hsa051342.22327929
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.21030380
8Staphylococcus aureus infection_Homo sapiens_hsa051502.18544448
9Antigen processing and presentation_Homo sapiens_hsa046122.08262463
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.07514129
11Lysosome_Homo sapiens_hsa041422.03998267
12Toxoplasmosis_Homo sapiens_hsa051451.97685172
13Rheumatoid arthritis_Homo sapiens_hsa053231.88625038
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.88540838
15Measles_Homo sapiens_hsa051621.82743410
16Pertussis_Homo sapiens_hsa051331.81032671
17TNF signaling pathway_Homo sapiens_hsa046681.79530634
18B cell receptor signaling pathway_Homo sapiens_hsa046621.68411584
19Influenza A_Homo sapiens_hsa051641.56134668
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.54445639
21Malaria_Homo sapiens_hsa051441.43257637
22Apoptosis_Homo sapiens_hsa042101.40909154
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.38166998
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.35673886
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31525233
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.30165221
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.29491230
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25279749
29Salmonella infection_Homo sapiens_hsa051321.20437104
30Primary immunodeficiency_Homo sapiens_hsa053401.19527763
31Synaptic vesicle cycle_Homo sapiens_hsa047211.17989230
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.17061390
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14203376
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.14011433
35Prion diseases_Homo sapiens_hsa050201.13223706
36VEGF signaling pathway_Homo sapiens_hsa043701.11286115
37Renal cell carcinoma_Homo sapiens_hsa052111.11267114
38Hepatitis B_Homo sapiens_hsa051611.10528966
39Chronic myeloid leukemia_Homo sapiens_hsa052201.09310619
40Shigellosis_Homo sapiens_hsa051311.08886947
41Acute myeloid leukemia_Homo sapiens_hsa052211.06442918
42Hepatitis C_Homo sapiens_hsa051601.04885933
43Tuberculosis_Homo sapiens_hsa051521.02702190
44Pentose phosphate pathway_Homo sapiens_hsa000301.02697553
45T cell receptor signaling pathway_Homo sapiens_hsa046601.02303858
46Non-small cell lung cancer_Homo sapiens_hsa052230.99689677
47Prolactin signaling pathway_Homo sapiens_hsa049170.99433565
48Hematopoietic cell lineage_Homo sapiens_hsa046400.98956126
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98558789
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98287572
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97091593
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.95885949
53Platelet activation_Homo sapiens_hsa046110.95637784
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95402853
55Herpes simplex infection_Homo sapiens_hsa051680.94920580
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94853048
57Phagosome_Homo sapiens_hsa041450.93678908
58Chemokine signaling pathway_Homo sapiens_hsa040620.93199201
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.92477413
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91898251
61ErbB signaling pathway_Homo sapiens_hsa040120.90990618
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86582002
63Pancreatic cancer_Homo sapiens_hsa052120.86418706
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84359144
65Adherens junction_Homo sapiens_hsa045200.84150312
66Autoimmune thyroid disease_Homo sapiens_hsa053200.83924785
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82917166
68Sphingolipid metabolism_Homo sapiens_hsa006000.82615403
69Focal adhesion_Homo sapiens_hsa045100.82161167
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.81569150
71GnRH signaling pathway_Homo sapiens_hsa049120.80898126
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80855484
73HTLV-I infection_Homo sapiens_hsa051660.80830611
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79935690
75Graft-versus-host disease_Homo sapiens_hsa053320.79724341
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78518411
77Circadian rhythm_Homo sapiens_hsa047100.76931758
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.75106061
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74967048
80Allograft rejection_Homo sapiens_hsa053300.73511120
81HIF-1 signaling pathway_Homo sapiens_hsa040660.73501790
82Inositol phosphate metabolism_Homo sapiens_hsa005620.73165607
83Vitamin digestion and absorption_Homo sapiens_hsa049770.70781443
84Bladder cancer_Homo sapiens_hsa052190.70155829
85Glioma_Homo sapiens_hsa052140.69762944
86mTOR signaling pathway_Homo sapiens_hsa041500.68681948
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68639416
88Small cell lung cancer_Homo sapiens_hsa052220.67892121
89Proteoglycans in cancer_Homo sapiens_hsa052050.67733701
90Choline metabolism in cancer_Homo sapiens_hsa052310.66303795
91Amoebiasis_Homo sapiens_hsa051460.66197179
92Collecting duct acid secretion_Homo sapiens_hsa049660.65911255
93Viral carcinogenesis_Homo sapiens_hsa052030.64714750
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64377855
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62593235
96Notch signaling pathway_Homo sapiens_hsa043300.62316184
97African trypanosomiasis_Homo sapiens_hsa051430.62140015
98FoxO signaling pathway_Homo sapiens_hsa040680.61678948
99Prostate cancer_Homo sapiens_hsa052150.60790381
100Insulin signaling pathway_Homo sapiens_hsa049100.60582844
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.60425873
102Viral myocarditis_Homo sapiens_hsa054160.60399267
103ECM-receptor interaction_Homo sapiens_hsa045120.59148610
104Colorectal cancer_Homo sapiens_hsa052100.58791210
105Insulin resistance_Homo sapiens_hsa049310.57795678
106Type I diabetes mellitus_Homo sapiens_hsa049400.55467217
107Epstein-Barr virus infection_Homo sapiens_hsa051690.55401371
108Vitamin B6 metabolism_Homo sapiens_hsa007500.54136328
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52376872
110Estrogen signaling pathway_Homo sapiens_hsa049150.51561720
111ABC transporters_Homo sapiens_hsa020100.51154504
112Endocytosis_Homo sapiens_hsa041440.50896892
113Complement and coagulation cascades_Homo sapiens_hsa046100.50850467
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49877075
115Vibrio cholerae infection_Homo sapiens_hsa051100.48825096
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47190636
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47145566
118MAPK signaling pathway_Homo sapiens_hsa040100.45012300
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44643812
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.43832068
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43798836
122Sulfur metabolism_Homo sapiens_hsa009200.43689504
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.42620926
124Type II diabetes mellitus_Homo sapiens_hsa049300.41153032
125Endometrial cancer_Homo sapiens_hsa052130.37616819
126Galactose metabolism_Homo sapiens_hsa000520.37464112
127Fructose and mannose metabolism_Homo sapiens_hsa000510.37456162
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33991182

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