UBD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T-helper 1 cell differentiation (GO:0045625)9.55026969
2positive regulation of antigen processing and presentation (GO:0002579)9.02355561
3positive regulation of Cdc42 GTPase activity (GO:0043089)8.43230414
4regulation of antigen processing and presentation (GO:0002577)7.53319047
5positive regulation of receptor biosynthetic process (GO:0010870)7.40118639
6positive regulation of granulocyte chemotaxis (GO:0071624)7.29604928
7positive regulation of T-helper 1 type immune response (GO:0002827)6.83956468
8complement activation, classical pathway (GO:0006958)6.72199233
9regulation of lipoprotein particle clearance (GO:0010984)6.70456492
10positive regulation of T-helper cell differentiation (GO:0045624)6.29008420
11positive regulation of interleukin-8 biosynthetic process (GO:0045416)6.26190576
12response to nitric oxide (GO:0071731)6.13541508
13positive regulation of glycoprotein biosynthetic process (GO:0010560)6.09779898
14positive regulation of neutrophil chemotaxis (GO:0090023)6.00114576
15positive regulation of neutrophil migration (GO:1902624)6.00114576
16peptide catabolic process (GO:0043171)5.93413744
17complement activation (GO:0006956)5.75609527
18NIK/NF-kappaB signaling (GO:0038061)5.68808603
19negative regulation of interleukin-10 production (GO:0032693)5.60174567
20response to prostaglandin E (GO:0034695)5.56232135
21oxygen transport (GO:0015671)5.51550827
22regulation of protein activation cascade (GO:2000257)5.39673582
23positive regulation of interleukin-1 beta secretion (GO:0050718)5.25647950
24regulation of complement activation (GO:0030449)5.22234298
25positive regulation of respiratory burst (GO:0060267)5.20544881
26protein activation cascade (GO:0072376)5.20016874
27negative regulation of fibrinolysis (GO:0051918)5.13126245
28positive regulation of glycoprotein metabolic process (GO:1903020)5.04696990
29regulation of Cdc42 GTPase activity (GO:0043088)4.98688556
30antigen processing and presentation of endogenous antigen (GO:0019883)4.96914115
31regulation of T-helper 1 type immune response (GO:0002825)4.93436848
32positive regulation of interleukin-1 secretion (GO:0050716)4.92004844
33dendritic cell chemotaxis (GO:0002407)4.91666331
34superoxide anion generation (GO:0042554)4.89770155
35complement activation, alternative pathway (GO:0006957)4.87298891
36regulation of fibrinolysis (GO:0051917)4.83038651
37drug catabolic process (GO:0042737)4.82947150
38cellular glucuronidation (GO:0052695)4.81316615
39hydrogen peroxide catabolic process (GO:0042744)4.77608361
40urea metabolic process (GO:0019627)4.75041460
41uronic acid metabolic process (GO:0006063)4.71768685
42glucuronate metabolic process (GO:0019585)4.71768685
43exogenous drug catabolic process (GO:0042738)4.70309944
44regulation of interleukin-1 beta secretion (GO:0050706)4.66164227
45epoxygenase P450 pathway (GO:0019373)4.65201078
46regulation of granulocyte chemotaxis (GO:0071622)4.62278815
47positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.56136921
48regulation of neutrophil chemotaxis (GO:0090022)4.48264486
49regulation of neutrophil migration (GO:1902622)4.48264486
50ethanol oxidation (GO:0006069)4.45464445
51regulation of T-helper cell differentiation (GO:0045622)4.43870161
52urea cycle (GO:0000050)4.41080930
53nitrogen cycle metabolic process (GO:0071941)4.38592647
54neurotransmitter catabolic process (GO:0042135)4.35269697
55antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.35011041
56phospholipid efflux (GO:0033700)4.31492513
57detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.29812001
58negative regulation of cholesterol transport (GO:0032375)4.29394125
59negative regulation of sterol transport (GO:0032372)4.29394125
60regulation of interleukin-1 secretion (GO:0050704)4.27561710
61response to prostaglandin (GO:0034694)4.27382031
62positive regulation of NF-kappaB import into nucleus (GO:0042346)4.23005604
63regulation of receptor biosynthetic process (GO:0010869)4.22136953
64positive regulation of interleukin-1 production (GO:0032732)4.22038515
65very-low-density lipoprotein particle assembly (GO:0034379)4.21414351
66fibrinolysis (GO:0042730)4.19933601
67positive regulation of interleukin-1 beta production (GO:0032731)4.19476857
68amine biosynthetic process (GO:0009309)4.18408398
69cellular biogenic amine biosynthetic process (GO:0042401)4.18408398
70regulation of cholesterol esterification (GO:0010872)4.14817761
71acute-phase response (GO:0006953)4.14104362
72antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.13146285
73low-density lipoprotein particle remodeling (GO:0034374)4.08700624
74regulation of interleukin-8 biosynthetic process (GO:0045414)4.06990446
75regulation of apoptotic cell clearance (GO:2000425)4.05943758
76protein-lipid complex remodeling (GO:0034368)3.96988430
77macromolecular complex remodeling (GO:0034367)3.96988430
78plasma lipoprotein particle remodeling (GO:0034369)3.96988430
79eosinophil migration (GO:0072677)3.95195960
80biotin metabolic process (GO:0006768)3.91103119
81positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.88836783
82renal absorption (GO:0070293)3.87061451
83intestinal absorption (GO:0050892)3.86558957
84protein carboxylation (GO:0018214)3.86305947
85peptidyl-glutamic acid carboxylation (GO:0017187)3.86305947
86angiotensin maturation (GO:0002003)3.85091745
87drug metabolic process (GO:0017144)3.83808206
88regulation of cellular extravasation (GO:0002691)3.83283687
89leukotriene biosynthetic process (GO:0019370)3.82141489
90erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.79110522
91L-phenylalanine catabolic process (GO:0006559)3.79110522
92bundle of His cell to Purkinje myocyte communication (GO:0086069)3.77339177
93triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.73644950
94regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.73141651
95erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.69438093
96L-phenylalanine metabolic process (GO:0006558)3.69438093
97tongue development (GO:0043586)3.68076893
98positive regulation of interleukin-12 production (GO:0032735)3.67389136
99regulation of humoral immune response (GO:0002920)3.66243548
100plasma lipoprotein particle assembly (GO:0034377)3.65371485
101glyoxylate metabolic process (GO:0046487)3.65104951
102bile acid metabolic process (GO:0008206)3.63654728
103negative regulation of blood coagulation (GO:0030195)3.61025677
104negative regulation of hemostasis (GO:1900047)3.61025677
105hormone catabolic process (GO:0042447)3.59237120
106positive regulation of triglyceride lipase activity (GO:0061365)3.58136824
107positive regulation of lipoprotein lipase activity (GO:0051006)3.58136824
108regulation of bile acid biosynthetic process (GO:0070857)3.55973086
109dendritic cell migration (GO:0036336)3.54111480
110ethanol metabolic process (GO:0006067)3.53223135
111blood coagulation, intrinsic pathway (GO:0007597)3.52726770
112bile acid and bile salt transport (GO:0015721)3.52600565
113high-density lipoprotein particle remodeling (GO:0034375)3.51974186
114fat-soluble vitamin biosynthetic process (GO:0042362)3.50758305
115regulation of respiratory burst (GO:0060263)3.50193519
116regulation of triglyceride catabolic process (GO:0010896)3.47463350
117negative regulation of coagulation (GO:0050819)3.45643829
118aromatic amino acid family catabolic process (GO:0009074)3.40592549
119positive regulation of pseudopodium assembly (GO:0031274)3.39848802
120positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.38315463
121phenylpropanoid metabolic process (GO:0009698)3.37326585
122pericardium development (GO:0060039)3.36953150
123regulation of RIG-I signaling pathway (GO:0039535)3.36314395
124lipoprotein metabolic process (GO:0042157)3.36275085
125primary alcohol catabolic process (GO:0034310)3.34100941
126acute inflammatory response (GO:0002526)3.33514331
127arginine metabolic process (GO:0006525)3.32890351
128plasma lipoprotein particle organization (GO:0071827)3.31060347
129cytokine secretion (GO:0050663)3.29968766
130cholesterol efflux (GO:0033344)3.29713454
131regulation of activation of Janus kinase activity (GO:0010533)3.29634069
132regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.29356975
133protein-lipid complex assembly (GO:0065005)3.29266307
134humoral immune response (GO:0006959)3.27784021
135hydrogen peroxide metabolic process (GO:0042743)3.27722365
136substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.26907214
137substrate-independent telencephalic tangential migration (GO:0021826)3.26907214
138negative regulation of protein activation cascade (GO:2000258)3.25970558
139alkaloid metabolic process (GO:0009820)3.24535873
140* dendritic cell differentiation (GO:0097028)3.23144462
141antimicrobial humoral response (GO:0019730)3.23046450
142antibacterial humoral response (GO:0019731)3.22722805
143daunorubicin metabolic process (GO:0044597)3.21512921
144polyketide metabolic process (GO:0030638)3.21512921
145doxorubicin metabolic process (GO:0044598)3.21512921
146maintenance of gastrointestinal epithelium (GO:0030277)3.19247245
147negative regulation of wound healing (GO:0061045)3.18153323
148leukotriene metabolic process (GO:0006691)3.17967503
149lung vasculature development (GO:0060426)3.16741952
150cellular response to ATP (GO:0071318)3.15770549
151protein-lipid complex subunit organization (GO:0071825)3.13446077
152diaphragm development (GO:0060539)3.13217519
153intestinal cholesterol absorption (GO:0030299)3.12570357
154neutrophil activation (GO:0042119)3.08465957
155reverse cholesterol transport (GO:0043691)3.07174496
156gas transport (GO:0015669)3.06838791
157tryptophan catabolic process (GO:0006569)3.06354350
158indole-containing compound catabolic process (GO:0042436)3.06354350
159indolalkylamine catabolic process (GO:0046218)3.06354350
160regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.06017424
161positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.04726085
162embryonic digestive tract development (GO:0048566)3.01916300
163synaptic transmission, cholinergic (GO:0007271)3.00656104
164positive regulation of transcription factor import into nucleus (GO:0042993)3.00131550
165regulation of pseudopodium assembly (GO:0031272)2.99958773
166nitric oxide biosynthetic process (GO:0006809)2.99675723
167regulation of natural killer cell differentiation (GO:0032823)2.96972143
168regulation of cholesterol homeostasis (GO:2000188)2.96743766
169bile acid biosynthetic process (GO:0006699)2.94253306
170glutathione biosynthetic process (GO:0006750)2.93821886
171triglyceride homeostasis (GO:0070328)2.93224471
172acylglycerol homeostasis (GO:0055090)2.93224471
173regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.90438197
174positive regulation of natural killer cell differentiation (GO:0032825)2.85941597
175positive regulation of leukocyte chemotaxis (GO:0002690)2.84807011
176positive regulation of DNA-templated transcription, initiation (GO:2000144)2.83632717
177skeletal muscle organ development (GO:0060538)2.80901774
178negative regulation of leukocyte apoptotic process (GO:2000107)2.79904961
179positive regulation of leukocyte migration (GO:0002687)2.79233437
180positive regulation of monocyte chemotaxis (GO:0090026)2.74481228
181positive regulation of glucose import (GO:0046326)2.73543316
182vitamin transmembrane transport (GO:0035461)2.73334751
183positive regulation of interleukin-4 production (GO:0032753)2.71112386
184granulocyte activation (GO:0036230)2.70751385
185regulation of interleukin-1 production (GO:0032652)2.67306693
186detection of bacterium (GO:0016045)2.67067416
187auditory behavior (GO:0031223)2.66523099
188superoxide metabolic process (GO:0006801)2.65634497
189positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.64519392
190positive regulation of cAMP-mediated signaling (GO:0043950)2.64061188
191nonribosomal peptide biosynthetic process (GO:0019184)2.63353098
192regulation of dendritic cell antigen processing and presentation (GO:0002604)12.7805173
193imidazole-containing compound metabolic process (GO:0052803)11.7045995
194regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)10.4120783

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.42079124
2VDR_22108803_ChIP-Seq_LS180_Human3.40231960
3RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.99593714
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.75329570
5CDX2_20551321_ChIP-Seq_CACO-2_Human2.72004655
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.50345030
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.25394444
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.24927759
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.05259697
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98910028
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.97267696
12GATA1_22025678_ChIP-Seq_K562_Human1.87340298
13GATA4_25053715_ChIP-Seq_YYC3_Human1.85461438
14DROSHA_22980978_ChIP-Seq_HELA_Human1.84196666
15FOXO3_23340844_ChIP-Seq_DLD1_Human1.82677980
16IGF1R_20145208_ChIP-Seq_DFB_Human1.78782181
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.73092913
18BP1_19119308_ChIP-ChIP_Hs578T_Human1.72698010
19SMAD_19615063_ChIP-ChIP_OVARY_Human1.69668211
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.65970965
21GATA6_25053715_ChIP-Seq_YYC3_Human1.65401548
22LXR_22292898_ChIP-Seq_THP-1_Human1.63114436
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.62211354
24IRF8_27001747_Chip-Seq_BMDM_Mouse1.61426352
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60955412
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59405922
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56891625
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55123679
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54151998
30ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48694137
31FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45960287
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.45337862
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44950281
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44505435
35STAT1_17558387_ChIP-Seq_HELA_Human1.44371708
36* HNF4A_19822575_ChIP-Seq_HepG2_Human1.44254780
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43826103
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.43460136
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.42744406
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.42029120
41EGR1_19032775_ChIP-ChIP_M12_Human1.39580265
42BCAT_22108803_ChIP-Seq_LS180_Human1.39320706
43SOX2_20726797_ChIP-Seq_SW620_Human1.39034011
44VDR_24787735_ChIP-Seq_THP-1_Human1.37748779
45CBP_20019798_ChIP-Seq_JUKART_Human1.36852798
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36852798
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35386862
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34881017
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34283153
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.33816153
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.33534490
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.33534490
53TCF4_18268006_ChIP-ChIP_LS174T_Human1.33441656
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.32575814
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31901741
56ETV2_25802403_ChIP-Seq_MESCs_Mouse1.31061224
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.30099065
58ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.28573257
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25770976
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23782908
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21696558
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21408377
63* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21269199
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.20193433
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.19833604
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19207581
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19020537
68* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17979508
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.17213195
70ELK4_26923725_Chip-Seq_MESODERM_Mouse1.15779780
71TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.15573993
72MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14238888
73CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13985415
74ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13590706
75TP53_18474530_ChIP-ChIP_U2OS_Human1.12007309
76RAD21_21589869_ChIP-Seq_MESCs_Mouse1.11375274
77ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10865896
78CLOCK_20551151_ChIP-Seq_293T_Human1.10205259
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09374558
80CDX2_22108803_ChIP-Seq_LS180_Human1.08273449
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08228649
82RACK7_27058665_Chip-Seq_MCF-7_Human1.07798617
83RNF2_27304074_Chip-Seq_ESCs_Mouse1.07629092
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06311348
85RXR_22158963_ChIP-Seq_LIVER_Mouse1.05331090
86LXR_22158963_ChIP-Seq_LIVER_Mouse1.04453672
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03834180
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03109146
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00912090
90EGR1_19374776_ChIP-ChIP_THP-1_Human1.00759207
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98204943
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97151233
93P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96787259
94NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96308689
95TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96292708
96AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96237452
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96159372
98NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95587805
99CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94857364
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94502951
101PIAS1_25552417_ChIP-Seq_VCAP_Human0.94349994
102ER_23166858_ChIP-Seq_MCF-7_Human0.92744849
103RXR_22108803_ChIP-Seq_LS180_Human0.92594266
104STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92158900
105TP53_20018659_ChIP-ChIP_R1E_Mouse0.91066270
106CJUN_26792858_Chip-Seq_BT549_Human0.90941611
107SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90484813
108TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90264831
109BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.89421967
110EZH2_27304074_Chip-Seq_ESCs_Mouse0.88200599
111CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87912277
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87664607
113* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86675129
114BCOR_27268052_Chip-Seq_Bcells_Human0.86181738
115PPARA_22158963_ChIP-Seq_LIVER_Mouse0.85985741
116* PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85144660
117SOX2_27498859_Chip-Seq_STOMACH_Mouse0.85003071
118P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84682492
119CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84448654
120NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84244782
121E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.83118469
122* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.82851962
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82304463
124CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82287204
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82263304
126FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82056767
127SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82026922
128FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.81997371
129TCF4_22108803_ChIP-Seq_LS180_Human0.81355176
130SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80766805
131PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80753180
132SA1_27219007_Chip-Seq_Bcells_Human0.80507160
133FOXA2_19822575_ChIP-Seq_HepG2_Human0.80386450
134RUNX1_26923725_Chip-Seq_HPCs_Mouse0.79775965
135LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.79552215
136BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79213682
137FLI1_27457419_Chip-Seq_LIVER_Mouse0.79133074
138DNAJC2_21179169_ChIP-ChIP_NT2_Human0.79091344
139CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.78244187
140BCL6_27268052_Chip-Seq_Bcells_Human0.78242916
141ELK3_25401928_ChIP-Seq_HUVEC_Human0.78182251
142AHR_22903824_ChIP-Seq_MCF-7_Human0.78176813
143VDR_24763502_ChIP-Seq_THP-1_Human0.78088228
144MYC_27129775_Chip-Seq_CORNEA_Mouse0.78058826
145PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.76574751
146SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75640886
147FOXA1_25552417_ChIP-Seq_VCAP_Human0.74330217
148GATA2_22383799_ChIP-Seq_G1ME_Mouse0.73847061
149SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71883525
150ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.71814572
151CEBPB_22108803_ChIP-Seq_LS180_Human0.70740404
152RXRA_24833708_ChIP-Seq_LIVER_Mouse0.69998265
153GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.68952889
154GATA3_24758297_ChIP-Seq_MCF-7_Human0.67992214
155GATA1_19941826_ChIP-Seq_K562_Human0.67922872
156GATA1_19941827_ChIP-Seq_MEL_Mouse0.67756902
157SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.67384767

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat8.68516138
2MP0002876_abnormal_thyroid_physiology7.27526289
3MP0002139_abnormal_hepatobiliary_system6.83435058
4MP0005645_abnormal_hypothalamus_physiol6.18251491
5MP0000685_abnormal_immune_system5.75061812
6MP0005360_urolithiasis5.44863397
7MP0005365_abnormal_bile_salt4.35486022
8MP0005085_abnormal_gallbladder_physiolo4.13660124
9MP0001348_abnormal_lacrimal_gland4.09876021
10MP0001346_abnormal_lacrimal_gland3.85226635
11MP0001835_abnormal_antigen_presentation3.76033401
12MP0001666_abnormal_nutrient_absorption3.62301042
13MP0004510_myositis3.53757855
14MP0002877_abnormal_melanocyte_morpholog3.37089303
15MP0009840_abnormal_foam_cell3.28210371
16MP0005310_abnormal_salivary_gland3.01173463
17MP0003195_calcinosis2.93027899
18MP0001873_stomach_inflammation2.76086450
19MP0003879_abnormal_hair_cell2.67878978
20MP0002735_abnormal_chemical_nociception2.56104928
21MP0003252_abnormal_bile_duct2.46878406
22MP0008875_abnormal_xenobiotic_pharmacok2.21449464
23MP0005671_abnormal_response_to2.19565968
24MP0006082_CNS_inflammation2.10085180
25MP0000003_abnormal_adipose_tissue2.05832173
26MP0010329_abnormal_lipoprotein_level2.04752808
27MP0005451_abnormal_body_composition1.81457466
28MP0003959_abnormal_lean_body1.81390376
29MP0005647_abnormal_sex_gland1.78037907
30MP0001764_abnormal_homeostasis1.77014938
31MP0004019_abnormal_vitamin_homeostasis1.76752242
32MP0003436_decreased_susceptibility_to1.72980511
33MP0005332_abnormal_amino_acid1.67135541
34MP0010234_abnormal_vibrissa_follicle1.62397173
35MP0005166_decreased_susceptibility_to1.59135014
36MP0002138_abnormal_hepatobiliary_system1.54200700
37MP0003191_abnormal_cellular_cholesterol1.53930651
38MP0001853_heart_inflammation1.48629525
39MP0000609_abnormal_liver_physiology1.45346636
40MP0000604_amyloidosis1.42467194
41MP0003866_abnormal_defecation1.39466230
42MP0001790_abnormal_immune_system1.38327404
43MP0005387_immune_system_phenotype1.38327404
44MP0003303_peritoneal_inflammation1.35257562
45MP0004264_abnormal_extraembryonic_tissu1.32322744
46MP0002971_abnormal_brown_adipose1.28077062
47MP0002118_abnormal_lipid_homeostasis1.19739521
48MP0003638_abnormal_response/metabolism_1.18387823
49MP0002148_abnormal_hypersensitivity_rea1.18082814
50MP0005058_abnormal_lysosome_morphology1.17359851
51MP0000470_abnormal_stomach_morphology1.13831652
52MP0009785_altered_susceptibility_to1.13590876
53MP0009115_abnormal_fat_cell1.12370769
54MP0001533_abnormal_skeleton_physiology1.09456950
55MP0001851_eye_inflammation1.08450701
56MP0001501_abnormal_sleep_pattern1.07533740
57MP0005319_abnormal_enzyme/_coenzyme1.06166473
58MP0002132_abnormal_respiratory_system1.05137633
59MP0004858_abnormal_nervous_system1.04919280
60MP0004947_skin_inflammation1.02220932
61MP0003763_abnormal_thymus_physiology1.02013763
62MP0009764_decreased_sensitivity_to1.01301140
63MP0001800_abnormal_humoral_immune0.98767482
64MP0004782_abnormal_surfactant_physiolog0.97503941
65MP0005584_abnormal_enzyme/coenzyme_acti0.96813819
66MP0005023_abnormal_wound_healing0.94581775
67MP0003453_abnormal_keratinocyte_physiol0.93803177
68MP0002136_abnormal_kidney_physiology0.91879591
69MP0002277_abnormal_respiratory_mucosa0.90524792
70MP0000858_altered_metastatic_potential0.89776916
71* MP0005025_abnormal_response_to0.89216429
72MP0000383_abnormal_hair_follicle0.89173019
73MP0005000_abnormal_immune_tolerance0.88584314
74MP0002405_respiratory_system_inflammati0.86424580
75MP0009333_abnormal_splenocyte_physiolog0.85116724
76MP0001881_abnormal_mammary_gland0.84497199
77MP0002160_abnormal_reproductive_system0.84362970
78MP0008874_decreased_physiological_sensi0.83545179
79MP0005464_abnormal_platelet_physiology0.83094323
80MP0000613_abnormal_salivary_gland0.82307816
81MP0003329_amyloid_beta_deposits0.82083157
82MP0010155_abnormal_intestine_physiology0.82048883
83MP0002733_abnormal_thermal_nociception0.81800377
84MP0001542_abnormal_bone_strength0.81636462
85MP0009379_abnormal_foot_pigmentation0.81586221
86MP0000681_abnormal_thyroid_gland0.81255592
87MP0009763_increased_sensitivity_to0.81141029
88MP0003868_abnormal_feces_composition0.80599411
89MP0003300_gastrointestinal_ulcer0.80534451
90MP0000249_abnormal_blood_vessel0.80279545
91MP0000477_abnormal_intestine_morphology0.80270328
92MP0009765_abnormal_xenobiotic_induced0.79892391
93MP0002970_abnormal_white_adipose0.77312912
94MP0000538_abnormal_urinary_bladder0.77186532
95MP0010678_abnormal_skin_adnexa0.75828318
96MP0005375_adipose_tissue_phenotype0.75719399
97MP0002006_tumorigenesis0.75652194
98MP0001845_abnormal_inflammatory_respons0.73881249
99MP0004134_abnormal_chest_morphology0.73253621
100MP0009642_abnormal_blood_homeostasis0.73133924
101MP0005636_abnormal_mineral_homeostasis0.72700099
102MP0010386_abnormal_urinary_bladder0.71878479
103MP0003183_abnormal_peptide_metabolism0.71784777
104MP0006054_spinal_hemorrhage0.70315403
105MP0000465_gastrointestinal_hemorrhage0.69627717
106MP0005164_abnormal_response_to0.69321854
107MP0005408_hypopigmentation0.68999003
108MP0003724_increased_susceptibility_to0.68542843
109MP0000579_abnormal_nail_morphology0.67178132
110MP0005409_darkened_coat_color0.66881448
111MP0008004_abnormal_stomach_pH0.66790087
112MP0002419_abnormal_innate_immunity0.65165886
113MP0005381_digestive/alimentary_phenotyp0.65093018
114MP0002452_abnormal_antigen_presenting0.64269715
115MP0005670_abnormal_white_adipose0.64197390
116MP0001664_abnormal_digestion0.63830381
117MP0010352_gastrointestinal_tract_polyps0.62838077
118MP0002734_abnormal_mechanical_nocicepti0.61174128
119MP0000598_abnormal_liver_morphology0.60695867
120MP0002723_abnormal_immune_serum0.60689508
121MP0005334_abnormal_fat_pad0.59855339
122MP0002998_abnormal_bone_remodeling0.58559142
123MP0003045_fibrosis0.58397790
124MP0000566_synostosis0.56684429
125MP0002638_abnormal_pupillary_reflex0.55964515
126MP0005448_abnormal_energy_balance0.55825156
127MP0002796_impaired_skin_barrier0.52398897
128MP0008469_abnormal_protein_level0.51010729
129MP0002693_abnormal_pancreas_physiology0.50254194
130MP0001485_abnormal_pinna_reflex0.49087463
131MP0000716_abnormal_immune_system0.48857931
132MP0001299_abnormal_eye_distance/0.48318817
133MP0003448_altered_tumor_morphology0.47988264
134MP0000427_abnormal_hair_cycle0.47340575
135MP0008872_abnormal_physiological_respon0.46115648
136* MP0001819_abnormal_immune_cell0.46091710
137MP0009643_abnormal_urine_homeostasis0.45452709
138MP0000467_abnormal_esophagus_morphology0.44505241
139* MP0002420_abnormal_adaptive_immunity0.44461504
140MP0001970_abnormal_pain_threshold0.43503914
141MP0000516_abnormal_urinary_system0.43321375
142MP0005367_renal/urinary_system_phenotyp0.43321375
143MP0003806_abnormal_nucleotide_metabolis0.42667220
144MP0001663_abnormal_digestive_system0.42048752
145MP0006138_congestive_heart_failure0.38242113
146MP0002909_abnormal_adrenal_gland0.37738720
147MP0008569_lethality_at_weaning0.37193082
148MP0005376_homeostasis/metabolism_phenot0.36557953
149MP0003075_altered_response_to0.36119148
150MP0002166_altered_tumor_susceptibility0.35660226
151MP0001756_abnormal_urination0.34985428

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)8.14246927
2Complement deficiency (HP:0004431)7.13857239
3Chronic mucocutaneous candidiasis (HP:0002728)6.75693182
4Recurrent cutaneous fungal infections (HP:0011370)6.75693182
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.54038383
6Abnormality of complement system (HP:0005339)6.35820887
7Glomerulonephritis (HP:0000099)6.31323290
8Aplasia/Hypoplasia of the spleen (HP:0010451)6.31268999
9Deep venous thrombosis (HP:0002625)5.87785787
10Hypobetalipoproteinemia (HP:0003563)5.55970272
11Prolonged neonatal jaundice (HP:0006579)5.14423791
12Keratoconjunctivitis (HP:0001096)5.11838636
13Abnormality of proline metabolism (HP:0010907)4.95571007
14Hydroxyprolinuria (HP:0003080)4.95571007
15Type I diabetes mellitus (HP:0100651)4.90825924
16Malnutrition (HP:0004395)4.83152024
17Nephritis (HP:0000123)4.61984817
18Upper limb muscle weakness (HP:0003484)4.61553664
19Double outlet right ventricle (HP:0001719)4.50531305
20Congenital malformation of the right heart (HP:0011723)4.50531305
21Increased IgE level (HP:0003212)4.44727077
22Right ventricular cardiomyopathy (HP:0011663)4.44364434
23Prolonged partial thromboplastin time (HP:0003645)4.41043983
24Eczematoid dermatitis (HP:0000976)4.37785306
25Tongue fasciculations (HP:0001308)4.26780382
26Asplenia (HP:0001746)4.20100585
27Type 2 muscle fiber atrophy (HP:0003554)4.15494474
28Abnormality of aromatic amino acid family metabolism (HP:0004338)4.14061341
29Abnormal pupillary function (HP:0007686)4.13237311
30Fat malabsorption (HP:0002630)4.07951923
31Muscle fibrillation (HP:0010546)4.07448629
32Confusion (HP:0001289)4.01727342
33Recurrent skin infections (HP:0001581)3.98421156
34Xanthomatosis (HP:0000991)3.96214024
35Abnormality of the gastric mucosa (HP:0004295)3.95664422
36Joint hemorrhage (HP:0005261)3.93458927
37Recurrent fungal infections (HP:0002841)3.83024091
38Truncus arteriosus (HP:0001660)3.81098488
39Abnormality of calcium-phosphate metabolism (HP:0100530)3.63599125
40Muscle fiber atrophy (HP:0100295)3.59104676
41Plantar hyperkeratosis (HP:0007556)3.55997186
42Hypercortisolism (HP:0001578)3.55453258
43Annular pancreas (HP:0001734)3.47005524
44Hemorrhage of the eye (HP:0011885)3.43094818
45Steatorrhea (HP:0002570)3.42321086
46Fatigable weakness (HP:0003473)3.36037149
47Abnormality of the neuromuscular junction (HP:0003398)3.36037149
48Conjugated hyperbilirubinemia (HP:0002908)3.34835122
49Reticulocytosis (HP:0001923)3.29805165
50Abnormality of the aortic arch (HP:0012303)3.22681229
51Intrahepatic cholestasis (HP:0001406)3.22562000
52Lip pit (HP:0100267)3.13319606
53Hypoplasia of the uterus (HP:0000013)3.13195230
54Palmoplantar hyperkeratosis (HP:0000972)3.10648861
55Abnormality of pyrimidine metabolism (HP:0004353)3.08844428
56Onycholysis (HP:0001806)3.04748664
57Abnormality of glutamine family amino acid metabolism (HP:0010902)3.03266515
58Hypolipoproteinemia (HP:0010981)3.00395669
59Purpura (HP:0000979)2.97197210
60Bilateral microphthalmos (HP:0007633)2.96352841
61Abnormality of the common coagulation pathway (HP:0010990)2.94243659
62Hypoplasia of dental enamel (HP:0006297)2.93859619
63Palmar hyperkeratosis (HP:0010765)2.89725259
64Interstitial pulmonary disease (HP:0006530)2.89527963
65Hyperglycinuria (HP:0003108)2.87906454
66Hyperglycemia (HP:0003074)2.86556890
67Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.85190087
68Milia (HP:0001056)2.84130163
69Abnormal pancreas size (HP:0012094)2.80759659
70Abnormal delayed hypersensitivity skin test (HP:0002963)2.77154951
71Weak cry (HP:0001612)2.75806609
72Recurrent pneumonia (HP:0006532)2.73759657
73Ileus (HP:0002595)2.70773243
74Vascular calcification (HP:0004934)2.69557770
75Hyperlipoproteinemia (HP:0010980)2.68749961
76Gingival bleeding (HP:0000225)2.62389578
77Xerostomia (HP:0000217)2.61620408
78Amelogenesis imperfecta (HP:0000705)2.59680804
79Gastrointestinal stroma tumor (HP:0100723)2.59350290
80Poikilocytosis (HP:0004447)2.58728488
81Abnormal auditory evoked potentials (HP:0006958)2.58603130
82Premature loss of primary teeth (HP:0006323)2.55582669
83Cholelithiasis (HP:0001081)2.52845721
84Agammaglobulinemia (HP:0004432)2.50537370
85Recurrent gram-negative bacterial infections (HP:0005420)2.48701624
86Chronic diarrhea (HP:0002028)2.48214074
87Recurrent bacterial skin infections (HP:0005406)2.47512275
88Spontaneous abortion (HP:0005268)2.46564475
89Tetraparesis (HP:0002273)2.46145467
90Recurrent lower respiratory tract infections (HP:0002783)2.43651336
91Keratitis (HP:0000491)2.42150778
92Hypergammaglobulinemia (HP:0010702)2.39922838
93Myositis (HP:0100614)2.39849663
94Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.39496282
95Hyperammonemia (HP:0001987)2.38003522
96Seborrheic dermatitis (HP:0001051)2.37032963
97Cardiovascular calcification (HP:0011915)2.36189947
98Vasculitis (HP:0002633)2.34397605
99Mitral stenosis (HP:0001718)2.34392012
100Pustule (HP:0200039)2.32506156
101Aplasia/hypoplasia of the uterus (HP:0008684)2.31608920
102Gastrointestinal infarctions (HP:0005244)2.31513808
103Transposition of the great arteries (HP:0001669)2.30887311
104Abnormal connection of the cardiac segments (HP:0011545)2.30887311
105Abnormal ventriculo-arterial connection (HP:0011563)2.30887311
106Abnormal gallbladder morphology (HP:0012437)2.30490173
107Joint swelling (HP:0001386)2.29955685
108Chronic otitis media (HP:0000389)2.29935585
109Recurrent bronchitis (HP:0002837)2.26379582
110Respiratory distress (HP:0002098)2.26189777
111Hepatitis (HP:0012115)2.23191415
112Abnormality of the nasal mucosa (HP:0000433)2.21699256
113Elevated erythrocyte sedimentation rate (HP:0003565)2.19217941
114Rickets (HP:0002748)2.16132748
115Urticaria (HP:0001025)2.14270310
116Fragile nails (HP:0001808)2.13733684
117Pulmonary embolism (HP:0002204)2.13575953
118Abnormality of nucleobase metabolism (HP:0010932)2.13443513
119Thrombophlebitis (HP:0004418)2.13434746
120Squamous cell carcinoma (HP:0002860)2.13368226
121Symphalangism affecting the phalanges of the hand (HP:0009773)2.13322087
122Pancreatitis (HP:0001733)2.12591210
123Hypophosphatemia (HP:0002148)2.12533127
124Ketoacidosis (HP:0001993)2.09940244
125Glycosuria (HP:0003076)2.09879151
126Abnormality of urine glucose concentration (HP:0011016)2.09879151
127Easy fatigability (HP:0003388)2.09268898
128Abnormality of placental membranes (HP:0011409)2.07046609
129Amniotic constriction ring (HP:0009775)2.07046609
130Recurrent abscess formation (HP:0002722)2.04837755
131Menorrhagia (HP:0000132)2.04683265
132Colitis (HP:0002583)2.04184984
133Abnormality of vitamin metabolism (HP:0100508)2.00694597
134Decreased muscle mass (HP:0003199)1.99958506
135Ventricular tachycardia (HP:0004756)1.99484309
136Nasal polyposis (HP:0100582)1.98730123
137Inflammation of the large intestine (HP:0002037)1.98217994
138Amyloidosis (HP:0011034)1.97501405
139Emphysema (HP:0002097)1.95331195
140Skin rash (HP:0000988)1.94913574
141Myocardial infarction (HP:0001658)1.94477197
142Gingivitis (HP:0000230)1.94457628
143Focal segmental glomerulosclerosis (HP:0000097)1.93626867
144Generalized aminoaciduria (HP:0002909)1.93465993
145Flat acetabular roof (HP:0003180)1.93121296
146Mediastinal lymphadenopathy (HP:0100721)1.93083770
147Cerebral palsy (HP:0100021)1.90668849
148Gangrene (HP:0100758)1.90315157
149Hypercholesterolemia (HP:0003124)1.89846979
150Abnormality of nail color (HP:0100643)1.88924953
151Alkalosis (HP:0001948)1.88170861
152Acanthocytosis (HP:0001927)1.86397471
153Gout (HP:0001997)1.85309434
154Pulmonary infiltrates (HP:0002113)1.85184129
155Villous atrophy (HP:0011473)1.84910762
156Abnormality of small intestinal villus morphology (HP:0011472)1.84910762
157Orchitis (HP:0100796)1.83439411
158Fragile skin (HP:0001030)1.82313359
159Atrophic scars (HP:0001075)1.81175739
160Abnormality of macrophages (HP:0004311)1.80712235
161Anophthalmia (HP:0000528)1.80455721
162Hypoparathyroidism (HP:0000829)1.80428185
163Abnormality of reticulocytes (HP:0004312)1.80403852
164Palpitations (HP:0001962)1.80049657
165Polygenic inheritance (HP:0010982)1.79709274
166Facial shape deformation (HP:0011334)1.77944788
167Potter facies (HP:0002009)1.77944788
168Epidermoid cyst (HP:0200040)1.77078480
169Widely patent fontanelles and sutures (HP:0004492)1.74335552
170Abnormality of serine family amino acid metabolism (HP:0010894)1.73192030
171Abnormality of glycine metabolism (HP:0010895)1.73192030
172Hemoptysis (HP:0002105)1.73184150
173Glomerulosclerosis (HP:0000096)1.73161152
174Abnormality of purine metabolism (HP:0004352)1.69718093
175Abnormality of alkaline phosphatase activity (HP:0004379)1.69700001
176Hepatocellular carcinoma (HP:0001402)1.69631993
177Abnormal enzyme/coenzyme activity (HP:0012379)1.69601288
178Abdominal distention (HP:0003270)1.67940685
179Elevated alkaline phosphatase (HP:0003155)1.67536168
180Late onset (HP:0003584)1.66655778
181Recurrent sinusitis (HP:0011108)1.66254421
182Polycythemia (HP:0001901)1.64591326
183Nausea (HP:0002018)1.62005698
184Periodontitis (HP:0000704)1.61546892
185Meningitis (HP:0001287)1.61223720
186Mucopolysacchariduria (HP:0008155)1.60873603

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K146.65868435
2MST1R4.45450659
3DYRK1B4.23498370
4RIPK13.59964189
5BMPR23.49184192
6IRAK43.47721073
7IRAK32.95062390
8ERBB32.77091398
9DYRK32.72684369
10EPHA32.64915395
11PTK62.33175627
12FGFR42.31978509
13TBK12.30766308
14IKBKE2.11270467
15EPHA22.11058434
16JAK32.10128299
17NME12.02249114
18EPHB11.99876743
19BCR1.88335179
20ACVR1B1.87641792
21TYK21.85287616
22MAP4K11.80776618
23CHUK1.71288431
24NLK1.71168065
25ITK1.64021079
26CDC42BPA1.63759927
27IKBKB1.62642531
28MAP3K121.61616265
29KDR1.60369840
30PRPF4B1.43647713
31SMG11.43137496
32STK241.42678895
33TIE11.41271694
34MET1.38775870
35JAK21.35088310
36ERN11.34904443
37TGFBR11.33886462
38JAK11.33096842
39MAP3K21.29180606
40PTK21.22231680
41BMPR1B1.21852067
42TRIB31.20231120
43FGFR31.17469918
44ZAP701.17004758
45MAP3K11.13518578
46AKT31.12307321
47EIF2AK21.12268888
48DAPK21.11648452
49BLK1.10245266
50MAPK111.04858755
51BTK1.04641732
52FRK1.04275415
53PDK21.03538482
54PIK3CA1.03173028
55NUAK11.02345996
56IRAK11.01123401
57TSSK60.97100040
58MST40.96621147
59SYK0.95730618
60TEC0.95719137
61PRKAA20.93064256
62RIPK40.89568660
63MAP3K30.87055329
64MAP3K130.85752960
65MAP3K100.83223805
66SCYL20.82735525
67NTRK10.82645520
68EPHB20.82206321
69PRKCQ0.81298862
70GRK50.80863734
71MKNK10.79693199
72MAPKAPK50.79150222
73FER0.78205862
74PKN10.73228180
75PDPK10.72441583
76PRKCD0.71049470
77CSF1R0.70951616
78ICK0.70602396
79PRKCI0.69890237
80CSK0.69712584
81KIT0.68724636
82TESK20.68507288
83MAPKAPK30.67975947
84SIK30.65916057
85CDK80.62931965
86HIPK20.62721369
87PIM20.62483258
88RET0.61334060
89PIK3CG0.59830389
90STK100.58341930
91MELK0.56467360
92PRKACG0.56323196
93MAPK150.55002371
94LYN0.53951562
95STK390.52857949
96OXSR10.50909743
97MATK0.50439397
98LMTK20.49923490
99MAPK70.49864783
100GRK60.49837489
101SIK10.48618648
102DYRK1A0.47274685
103HCK0.47072805
104CDK30.46912474
105PDK10.45713869
106SRC0.45593858
107LCK0.44787858
108PLK20.42626361
109EGFR0.42250978
110LRRK20.42011694
111TGFBR20.41598900
112DDR20.41212887
113IGF1R0.40515239
114PKN20.40305661
115FGR0.39208270
116DMPK0.38872102
117MAP2K20.38290135
118PRKCE0.38002781
119MAP3K70.37811368
120MAP3K110.37235639
121RPS6KB20.36539201
122GRK10.33928164
123PRKDC0.32770149
124FYN0.32581328
125ERBB40.31954967
126INSR0.31948924
127NEK90.31512458
128TXK0.30775866
129CDK60.29778736
130MAPKAPK20.29271623
131MAP3K60.29064378
132ERBB20.28918564
133PRKCZ0.28820800
134LATS10.28515390
135MYLK0.25813531
136ROCK20.23190568
137GRK70.23017572
138TESK10.22988759
139DAPK10.22392339
140PRKG20.21454302
141PDGFRA0.20590185
142ADRBK10.18669714
143INSRR0.18473007
144MAPK80.18096627
145ADRBK20.17868358
146PRKCA0.17029216
147BRSK10.15666817
148RPS6KA50.15276581
149ZAK0.14831283

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004006.17145133
2Asthma_Homo sapiens_hsa053104.46415391
3Histidine metabolism_Homo sapiens_hsa003404.17744258
4Primary immunodeficiency_Homo sapiens_hsa053403.44460642
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.25438631
6NF-kappa B signaling pathway_Homo sapiens_hsa040643.12332812
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.02077978
8Caffeine metabolism_Homo sapiens_hsa002322.88626837
9Antigen processing and presentation_Homo sapiens_hsa046122.75936319
10Fat digestion and absorption_Homo sapiens_hsa049752.56407187
11Retinol metabolism_Homo sapiens_hsa008302.53019288
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.51077545
13Cyanoamino acid metabolism_Homo sapiens_hsa004602.39799140
14Chemical carcinogenesis_Homo sapiens_hsa052042.31608090
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.29590814
16Phenylalanine metabolism_Homo sapiens_hsa003602.25456331
17Drug metabolism - other enzymes_Homo sapiens_hsa009832.18103333
18Steroid hormone biosynthesis_Homo sapiens_hsa001402.12347384
19Leishmaniasis_Homo sapiens_hsa051401.87333280
20Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.86778908
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.86488780
22Arginine biosynthesis_Homo sapiens_hsa002201.81652336
23Fatty acid degradation_Homo sapiens_hsa000711.79555168
24Autoimmune thyroid disease_Homo sapiens_hsa053201.74577526
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64383862
26Linoleic acid metabolism_Homo sapiens_hsa005911.60779294
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.58870922
28Starch and sucrose metabolism_Homo sapiens_hsa005001.58053645
29Bile secretion_Homo sapiens_hsa049761.57424004
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55798446
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55061421
32Sulfur metabolism_Homo sapiens_hsa009201.48991471
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46939662
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.45301229
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.43838862
36African trypanosomiasis_Homo sapiens_hsa051431.41156717
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38677593
38Renin-angiotensin system_Homo sapiens_hsa046141.34290877
39Allograft rejection_Homo sapiens_hsa053301.31676196
40Ether lipid metabolism_Homo sapiens_hsa005651.29969118
41Melanoma_Homo sapiens_hsa052181.24116629
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22059248
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18192532
44Osteoclast differentiation_Homo sapiens_hsa043801.16882525
45Vitamin digestion and absorption_Homo sapiens_hsa049771.14927019
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14440823
47Toxoplasmosis_Homo sapiens_hsa051451.13847767
48Chemokine signaling pathway_Homo sapiens_hsa040621.06428606
49Fructose and mannose metabolism_Homo sapiens_hsa000511.05565795
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03548075
51Butanoate metabolism_Homo sapiens_hsa006501.02799408
52Other glycan degradation_Homo sapiens_hsa005111.01713936
53Rheumatoid arthritis_Homo sapiens_hsa053230.98449012
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.95926728
55Tyrosine metabolism_Homo sapiens_hsa003500.95685536
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92898840
57Legionellosis_Homo sapiens_hsa051340.92448535
58Apoptosis_Homo sapiens_hsa042100.89985774
59Arachidonic acid metabolism_Homo sapiens_hsa005900.88655826
60Tryptophan metabolism_Homo sapiens_hsa003800.87890300
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.84730833
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83690715
63ABC transporters_Homo sapiens_hsa020100.81953000
64Mineral absorption_Homo sapiens_hsa049780.81926881
65Tuberculosis_Homo sapiens_hsa051520.81893973
66TNF signaling pathway_Homo sapiens_hsa046680.81348345
67Glycerolipid metabolism_Homo sapiens_hsa005610.81318449
68Peroxisome_Homo sapiens_hsa041460.81202056
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81177028
70Protein digestion and absorption_Homo sapiens_hsa049740.80778685
71Malaria_Homo sapiens_hsa051440.79266392
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72374772
73p53 signaling pathway_Homo sapiens_hsa041150.69986156
74Prion diseases_Homo sapiens_hsa050200.69133335
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67695092
76Pertussis_Homo sapiens_hsa051330.66255941
77Glutathione metabolism_Homo sapiens_hsa004800.65747283
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65068470
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64714960
80Galactose metabolism_Homo sapiens_hsa000520.64580967
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61794561
82Amoebiasis_Homo sapiens_hsa051460.61524794
83Small cell lung cancer_Homo sapiens_hsa052220.60671564
84Hepatitis C_Homo sapiens_hsa051600.59688830
85Measles_Homo sapiens_hsa051620.58461248
86Pyruvate metabolism_Homo sapiens_hsa006200.57698294
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.57560393
88beta-Alanine metabolism_Homo sapiens_hsa004100.55932315
89Ras signaling pathway_Homo sapiens_hsa040140.52739645
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52607131
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51776734
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50977638
93Herpes simplex infection_Homo sapiens_hsa051680.49469761
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47851346
95Pancreatic secretion_Homo sapiens_hsa049720.46989490
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46776404
97Staphylococcus aureus infection_Homo sapiens_hsa051500.46376797
98Arginine and proline metabolism_Homo sapiens_hsa003300.46265825
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.46094997
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45266894
101Fatty acid metabolism_Homo sapiens_hsa012120.45171725
102Graft-versus-host disease_Homo sapiens_hsa053320.44853530
103Influenza A_Homo sapiens_hsa051640.44216710
104Biosynthesis of amino acids_Homo sapiens_hsa012300.44041318
105Systemic lupus erythematosus_Homo sapiens_hsa053220.44005089
106MAPK signaling pathway_Homo sapiens_hsa040100.43075031
107Pathways in cancer_Homo sapiens_hsa052000.42939519
108Dorso-ventral axis formation_Homo sapiens_hsa043200.42835873
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40401109
110Phagosome_Homo sapiens_hsa041450.39687604
111HTLV-I infection_Homo sapiens_hsa051660.39377571
112Salivary secretion_Homo sapiens_hsa049700.38786556
113Pancreatic cancer_Homo sapiens_hsa052120.36961643
114Type I diabetes mellitus_Homo sapiens_hsa049400.36311992
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.35869422
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35798039
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34926783
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34326482
119Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33245563
120Vitamin B6 metabolism_Homo sapiens_hsa007500.32884329
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.32701677
122Adherens junction_Homo sapiens_hsa045200.32644273
123Carbon metabolism_Homo sapiens_hsa012000.32332117
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29298431
125Complement and coagulation cascades_Homo sapiens_hsa046100.28806219
126Rap1 signaling pathway_Homo sapiens_hsa040150.28391572
127Hippo signaling pathway_Homo sapiens_hsa043900.28359959
128Amphetamine addiction_Homo sapiens_hsa050310.26061406
129Prolactin signaling pathway_Homo sapiens_hsa049170.25922954
130B cell receptor signaling pathway_Homo sapiens_hsa046620.25252923
131PPAR signaling pathway_Homo sapiens_hsa033200.24501987
132Calcium signaling pathway_Homo sapiens_hsa040200.24172461
133Basal cell carcinoma_Homo sapiens_hsa052170.23521232
134Sphingolipid metabolism_Homo sapiens_hsa006000.22747434
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.21337342
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.20882279
137Vibrio cholerae infection_Homo sapiens_hsa051100.19634297
138Lysosome_Homo sapiens_hsa041420.19506287
139Olfactory transduction_Homo sapiens_hsa047400.18848537
140Proteasome_Homo sapiens_hsa030500.15918839
141Thyroid hormone synthesis_Homo sapiens_hsa049180.15084562
142Synaptic vesicle cycle_Homo sapiens_hsa047210.14720579
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13866436
144Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.13654930
145Hematopoietic cell lineage_Homo sapiens_hsa046400.13587963
146Viral myocarditis_Homo sapiens_hsa054160.12584855
147Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12275026
148TGF-beta signaling pathway_Homo sapiens_hsa043500.11763714

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