UBE2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.74215124
2positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.46558373
3sarcoplasmic reticulum calcium ion transport (GO:0070296)4.41709909
4neuronal action potential propagation (GO:0019227)4.33447103
5regulation of cell communication by electrical coupling (GO:0010649)4.26513828
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.23444900
7respiratory electron transport chain (GO:0022904)4.12488884
8ATP synthesis coupled proton transport (GO:0015986)4.06083975
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.06083975
10electron transport chain (GO:0022900)4.05244586
11regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.98912475
12platelet dense granule organization (GO:0060155)3.98742798
13regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.98424036
14respiratory chain complex IV assembly (GO:0008535)3.89830522
15synaptic vesicle exocytosis (GO:0016079)3.73349340
16muscle filament sliding (GO:0030049)3.70987238
17actin-myosin filament sliding (GO:0033275)3.70987238
18DNA deamination (GO:0045006)3.62991968
19regulation of acyl-CoA biosynthetic process (GO:0050812)3.59351523
20detection of calcium ion (GO:0005513)3.57363573
21neuron cell-cell adhesion (GO:0007158)3.55795675
22protein complex biogenesis (GO:0070271)3.49388805
23regulation of skeletal muscle contraction (GO:0014819)3.49290510
24proteasome assembly (GO:0043248)3.43442342
25cytochrome complex assembly (GO:0017004)3.42493531
26regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.39837256
27vocalization behavior (GO:0071625)3.38976154
28detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.36980557
29regulation of relaxation of muscle (GO:1901077)3.36238597
30skeletal muscle contraction (GO:0003009)3.35475718
31regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.32955416
32regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.32697166
33regulation of glucokinase activity (GO:0033131)3.30407781
34regulation of hexokinase activity (GO:1903299)3.30407781
35regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.28479984
36negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.27336437
37adaptation of signaling pathway (GO:0023058)3.24850439
38tricarboxylic acid cycle (GO:0006099)3.24785340
39regulation of coenzyme metabolic process (GO:0051196)3.23504482
40regulation of cofactor metabolic process (GO:0051193)3.23504482
41cytidine metabolic process (GO:0046087)3.22579588
42cytidine catabolic process (GO:0006216)3.22579588
43cytidine deamination (GO:0009972)3.22579588
44regulation of synaptic vesicle exocytosis (GO:2000300)3.22515477
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.22143645
46protein localization to synapse (GO:0035418)3.17579684
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16472146
48water-soluble vitamin biosynthetic process (GO:0042364)3.14958018
49mitochondrial respiratory chain complex assembly (GO:0033108)3.13761182
50regulation of synaptic vesicle transport (GO:1902803)3.08266878
51inositol phosphate catabolic process (GO:0071545)3.08114193
52adenosine metabolic process (GO:0046085)3.08114087
53negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.05274642
54actin-mediated cell contraction (GO:0070252)3.03472172
55glutamate secretion (GO:0014047)3.01603318
56mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.99267528
57energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.98980379
58ATP hydrolysis coupled proton transport (GO:0015991)2.98980379
59mitochondrial respiratory chain complex I assembly (GO:0032981)2.98398865
60NADH dehydrogenase complex assembly (GO:0010257)2.98398865
61mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.98398865
62sarcomere organization (GO:0045214)2.97062982
63positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96121596
64regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.95820002
65protein K11-linked deubiquitination (GO:0035871)2.94814428
66regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.93830067
67regulation of short-term neuronal synaptic plasticity (GO:0048172)2.93327214
68succinate metabolic process (GO:0006105)2.93204879
69regulation of protein glycosylation (GO:0060049)2.90892465
70dopamine transport (GO:0015872)2.90399597
71positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.90257878
72cullin deneddylation (GO:0010388)2.89250533
73auditory receptor cell stereocilium organization (GO:0060088)2.86654180
74regulation of calcium ion transmembrane transporter activity (GO:1901019)2.84275726
75regulation of calcium ion transmembrane transport (GO:1903169)2.84275726
76regulation of cAMP-dependent protein kinase activity (GO:2000479)2.82406656
77NADH metabolic process (GO:0006734)2.82024272
78pyrimidine ribonucleoside catabolic process (GO:0046133)2.81972064
79keratinocyte development (GO:0003334)2.81599739
80negative regulation of calcium ion transmembrane transport (GO:1903170)2.80178191
81negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.80178191
82DNA double-strand break processing (GO:0000729)2.78906194
83striated muscle contraction (GO:0006941)2.78731738
84positive regulation of mitochondrial fission (GO:0090141)2.78160024
85glycogen catabolic process (GO:0005980)2.77850854
86regulation of glutamate receptor signaling pathway (GO:1900449)2.77789444
87calcium-mediated signaling using intracellular calcium source (GO:0035584)2.75970225
88signal peptide processing (GO:0006465)2.75660691
89negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74850657
90phosphorylated carbohydrate dephosphorylation (GO:0046838)2.73136343
91inositol phosphate dephosphorylation (GO:0046855)2.73136343
92negative regulation of cation channel activity (GO:2001258)2.72861902
93protein targeting to Golgi (GO:0000042)2.72648453
94oxidative phosphorylation (GO:0006119)2.72155232
95presynaptic membrane assembly (GO:0097105)2.71921204
96regulation of membrane repolarization (GO:0060306)2.71539442
97protein localization to cilium (GO:0061512)2.70717510
98xenobiotic catabolic process (GO:0042178)2.68965469
99mannosylation (GO:0097502)2.68430979
100plasma membrane repair (GO:0001778)2.67360108
101membrane depolarization during action potential (GO:0086010)2.66239732
102anterograde synaptic vesicle transport (GO:0048490)2.65894681
103establishment of protein localization to Golgi (GO:0072600)2.65417578
104neurotransmitter secretion (GO:0007269)2.65275497
105response to pheromone (GO:0019236)2.64697704
106positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.64261950
107oxygen transport (GO:0015671)2.63882103
108negative regulation of potassium ion transmembrane transport (GO:1901380)2.63387863
109cardiac muscle contraction (GO:0060048)2.63239183
110protein deneddylation (GO:0000338)2.62229801
111neuromuscular synaptic transmission (GO:0007274)2.62189900
112neural tube formation (GO:0001841)2.62008415
113inner mitochondrial membrane organization (GO:0007007)2.60490371
114negative regulation of dendrite morphogenesis (GO:0050774)2.60243940
115polyol catabolic process (GO:0046174)2.57000164
116negative regulation of membrane potential (GO:0045837)2.56678835
117response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.56375909
118glucan catabolic process (GO:0009251)2.53423778
119regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.53098691
120transferrin transport (GO:0033572)2.52774301
121hydrogen ion transmembrane transport (GO:1902600)2.51377422
122regulation of sulfur metabolic process (GO:0042762)2.50251137
123regulation of actin filament-based movement (GO:1903115)2.49078849
124establishment of protein localization to mitochondrial membrane (GO:0090151)2.49074857
125positive regulation of glycolytic process (GO:0045821)2.48316841
126myofibril assembly (GO:0030239)2.48063917
127cellular ketone body metabolic process (GO:0046950)2.47451993
128fucose catabolic process (GO:0019317)2.47060475
129L-fucose metabolic process (GO:0042354)2.47060475
130L-fucose catabolic process (GO:0042355)2.47060475
131negative regulation of ion transmembrane transporter activity (GO:0032413)2.46530232
132regulation of sarcomere organization (GO:0060297)2.46440984
133neuron recognition (GO:0008038)2.45548921
134protein neddylation (GO:0045116)2.45352642
135regulation of memory T cell differentiation (GO:0043380)2.44872667
136regulation of cation channel activity (GO:2001257)2.44241302
137regulation of oxidative phosphorylation (GO:0002082)2.43724561
138striatum development (GO:0021756)2.43668559
139regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.43131047
140regulation of striated muscle contraction (GO:0006942)2.42804299
141negative regulation of heart rate (GO:0010459)2.42448593
142female mating behavior (GO:0060180)2.42017691
143inner ear receptor stereocilium organization (GO:0060122)2.41719658
144presynaptic membrane organization (GO:0097090)2.41137990
145ATP biosynthetic process (GO:0006754)2.40642019
146postsynaptic membrane organization (GO:0001941)2.40086851
147neuron-neuron synaptic transmission (GO:0007270)2.39763699
148regulation of vesicle fusion (GO:0031338)2.39683299
149positive regulation of potassium ion transmembrane transport (GO:1901381)2.39512116
150regulation of synapse structural plasticity (GO:0051823)2.39440396
151piRNA metabolic process (GO:0034587)2.39093976
152nucleotide transmembrane transport (GO:1901679)2.37932813
153RNA destabilization (GO:0050779)2.34268577
154S-adenosylmethionine metabolic process (GO:0046500)2.33641963
155protein-cofactor linkage (GO:0018065)2.32025190
156ketone body metabolic process (GO:1902224)2.31671902
157prenylation (GO:0097354)2.31335321
158protein prenylation (GO:0018342)2.31335321
159protein localization to Golgi apparatus (GO:0034067)2.30918333
160negative regulation of telomere maintenance (GO:0032205)2.30456403
161retrograde transport, vesicle recycling within Golgi (GO:0000301)2.29735666
162preassembly of GPI anchor in ER membrane (GO:0016254)2.25538940
163behavioral response to nicotine (GO:0035095)2.24522173
164positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.22453182
165indolalkylamine metabolic process (GO:0006586)2.22288149
166L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.21182325
167heart contraction (GO:0060047)2.19482544
168heart process (GO:0003015)2.19482544
169nonmotile primary cilium assembly (GO:0035058)2.18736524
170lactate metabolic process (GO:0006089)2.18395526
171magnesium ion transport (GO:0015693)2.18337209
172negative regulation of protein autophosphorylation (GO:0031953)2.18071856
173exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.17417433
174negative regulation of T-helper cell differentiation (GO:0045623)2.17315106
175negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.17315106
176cornea development in camera-type eye (GO:0061303)2.17152717
177nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.17098868
178detection of light stimulus involved in sensory perception (GO:0050962)2.16131655
179detection of light stimulus involved in visual perception (GO:0050908)2.16131655
180ubiquinone biosynthetic process (GO:0006744)2.15851029
181amine catabolic process (GO:0009310)2.15848731
182cellular biogenic amine catabolic process (GO:0042402)2.15848731
183regulation of type B pancreatic cell apoptotic process (GO:2000674)2.15299628
184regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.14459405
185positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.14459405
186photoreceptor cell maintenance (GO:0045494)2.11743542
187positive regulation of protein autophosphorylation (GO:0031954)2.11108245
188purine-containing compound salvage (GO:0043101)2.10770080
189regulation of neurotransmitter uptake (GO:0051580)2.10405425

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.61774072
2GBX2_23144817_ChIP-Seq_PC3_Human3.12414036
3TAF15_26573619_Chip-Seq_HEK293_Human2.68595607
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67235258
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.60256691
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52427479
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.39966466
8VDR_22108803_ChIP-Seq_LS180_Human2.36430871
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.33960363
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32332901
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.29597586
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.16356323
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15468459
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14721085
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11432283
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11432283
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05991091
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05668161
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05070407
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.04743649
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.04436735
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03591169
23REST_21632747_ChIP-Seq_MESCs_Mouse1.96529852
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.96186723
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96113722
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.92216150
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91625618
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90391500
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87993800
30EWS_26573619_Chip-Seq_HEK293_Human1.86458345
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.85596662
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.84237915
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.77965650
34AR_21572438_ChIP-Seq_LNCaP_Human1.77151876
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.75002759
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.73743984
37IGF1R_20145208_ChIP-Seq_DFB_Human1.72527241
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68167582
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67691845
40* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65575375
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.63871745
42SMAD4_21799915_ChIP-Seq_A2780_Human1.63601990
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.63397727
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.63179847
45P300_19829295_ChIP-Seq_ESCs_Human1.62911263
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61782629
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60370512
48* ELK1_19687146_ChIP-ChIP_HELA_Human1.60336512
49ZNF274_21170338_ChIP-Seq_K562_Hela1.58122489
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.57751601
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54519696
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.53329075
53* RARB_27405468_Chip-Seq_BRAIN_Mouse1.53069014
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.52517838
55FUS_26573619_Chip-Seq_HEK293_Human1.48110739
56CRX_20693478_ChIP-Seq_RETINA_Mouse1.48039344
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.46148269
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.46132378
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.44188414
60CBP_20019798_ChIP-Seq_JUKART_Human1.43899566
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43899566
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43035768
63RNF2_27304074_Chip-Seq_NSC_Mouse1.42817026
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40505299
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39377076
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38654532
67CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38478873
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38370399
69VDR_23849224_ChIP-Seq_CD4+_Human1.37819866
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34876732
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34789892
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33369036
73AR_25329375_ChIP-Seq_VCAP_Human1.33342975
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.32840340
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32260670
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32166830
77SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.31754663
78TP53_22573176_ChIP-Seq_HFKS_Human1.31464003
79EP300_21415370_ChIP-Seq_HL-1_Mouse1.30934153
80OCT4_21477851_ChIP-Seq_ESCs_Mouse1.28686702
81CDX2_22108803_ChIP-Seq_LS180_Human1.28676569
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.28173461
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23488102
84IRF8_21731497_ChIP-ChIP_J774_Mouse1.23286140
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23198058
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.23003722
87DROSHA_22980978_ChIP-Seq_HELA_Human1.22705149
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20682230
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20126074
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.19276267
91HTT_18923047_ChIP-ChIP_STHdh_Human1.18622191
92ER_23166858_ChIP-Seq_MCF-7_Human1.18284791
93FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18182813
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.18182813
95BCAT_22108803_ChIP-Seq_LS180_Human1.17526938
96SOX2_21211035_ChIP-Seq_LN229_Gbm1.17334128
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17136326
98SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16645323
99IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16058798
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.15173975
101CMYC_18555785_Chip-Seq_ESCs_Mouse1.14093156
102STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13147546
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12760627
104FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12435384
105FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12188303
106IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11922334
107EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09459524
108GATA3_26560356_Chip-Seq_TH2_Human1.09089800
109PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08395521
110LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08288777
111SALL4_22934838_ChIP-ChIP_CD34+_Human1.07587097
112P300_18555785_Chip-Seq_ESCs_Mouse1.07090157
113PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06438167
114SMAD_19615063_ChIP-ChIP_OVARY_Human1.04249713
115AR_20517297_ChIP-Seq_VCAP_Human1.03823659
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01959756
117P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01426534
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99316415
119MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97070773
120TP53_20018659_ChIP-ChIP_R1E_Mouse0.96229678
121* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95800810
122* RING1B_27294783_Chip-Seq_ESCs_Mouse0.95710556
123TP53_18474530_ChIP-ChIP_U2OS_Human0.93637333
124ESR1_20079471_ChIP-ChIP_T-47D_Human0.93628602
125CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93599737
126STAT3_23295773_ChIP-Seq_U87_Human0.93541872
127RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92326525
128FLI1_27457419_Chip-Seq_LIVER_Mouse0.91934541
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91760570
130NANOG_18555785_Chip-Seq_ESCs_Mouse0.88646705
131RUNX2_22187159_ChIP-Seq_PCA_Human0.88136650
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87590617
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87590617
134CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87582750
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87307911
136IKZF1_21737484_ChIP-ChIP_HCT116_Human0.86849686
137NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86774065
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86367946
139FLI1_21867929_ChIP-Seq_TH2_Mouse0.86274375
140DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86164410
141PRDM14_20953172_ChIP-Seq_ESCs_Human0.84150958
142MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83739648
143TCF4_23295773_ChIP-Seq_U87_Human0.83735185
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83087119
145NANOG_19829295_ChIP-Seq_ESCs_Human0.82790927
146SOX2_19829295_ChIP-Seq_ESCs_Human0.82790927
147SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.81547290
148SMAD4_21741376_ChIP-Seq_EPCs_Human0.81324538
149PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81143059
150TCF4_22108803_ChIP-Seq_LS180_Human0.80883462
151P53_22387025_ChIP-Seq_ESCs_Mouse0.80350148
152ARNT_22903824_ChIP-Seq_MCF-7_Human0.80015769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.10297430
2MP0003646_muscle_fatigue3.67911849
3MP0003880_abnormal_central_pattern3.56335648
4MP0004145_abnormal_muscle_electrophysio3.54447058
5MP0000751_myopathy3.46283516
6MP0004859_abnormal_synaptic_plasticity2.97127647
7MP0004270_analgesia2.93191170
8MP0000749_muscle_degeneration2.80184251
9MP0002822_catalepsy2.76814854
10MP0006276_abnormal_autonomic_nervous2.58102130
11MP0003635_abnormal_synaptic_transmissio2.47948485
12MP0004036_abnormal_muscle_relaxation2.41400053
13MP0003724_increased_susceptibility_to2.33278407
14MP0008877_abnormal_DNA_methylation2.32616978
15MP0000372_irregular_coat_pigmentation2.31276830
16MP0002734_abnormal_mechanical_nocicepti2.23507738
17MP0002102_abnormal_ear_morphology2.21557512
18MP0009745_abnormal_behavioral_response2.20078753
19MP0001968_abnormal_touch/_nociception2.17933502
20MP0002735_abnormal_chemical_nociception2.17921411
21MP0004215_abnormal_myocardial_fiber2.15998778
22MP0002277_abnormal_respiratory_mucosa2.11228626
23MP0002063_abnormal_learning/memory/cond2.06086428
24MP0000569_abnormal_digit_pigmentation2.04470329
25MP0002064_seizures2.04101476
26MP0009046_muscle_twitch1.95080331
27MP0004147_increased_porphyrin_level1.92864320
28MP0002572_abnormal_emotion/affect_behav1.89618241
29MP0002272_abnormal_nervous_system1.89298880
30MP0000747_muscle_weakness1.86192292
31MP0004130_abnormal_muscle_cell1.84577698
32MP0002733_abnormal_thermal_nociception1.83923637
33MP0004484_altered_response_of1.82441561
34MP0000013_abnormal_adipose_tissue1.81370312
35MP0002106_abnormal_muscle_physiology1.80712485
36MP0005620_abnormal_muscle_contractility1.80316603
37MP0001970_abnormal_pain_threshold1.79965399
38MP0001440_abnormal_grooming_behavior1.78210494
39MP0002736_abnormal_nociception_after1.78059216
40MP0001529_abnormal_vocalization1.77304575
41MP0005084_abnormal_gallbladder_morpholo1.76167368
42MP0001984_abnormal_olfaction1.73366285
43MP0005551_abnormal_eye_electrophysiolog1.72034907
44MP0001501_abnormal_sleep_pattern1.71063070
45MP0006036_abnormal_mitochondrial_physio1.65574076
46MP0003806_abnormal_nucleotide_metabolis1.65289224
47MP0004233_abnormal_muscle_weight1.59805692
48MP0003011_delayed_dark_adaptation1.58946959
49MP0005645_abnormal_hypothalamus_physiol1.58835490
50MP0004084_abnormal_cardiac_muscle1.57094505
51MP0002163_abnormal_gland_morphology1.56840753
52MP0002067_abnormal_sensory_capabilities1.53995547
53MP0000759_abnormal_skeletal_muscle1.53519187
54MP0005369_muscle_phenotype1.53076912
55MP0005075_abnormal_melanosome_morpholog1.52219409
56MP0005330_cardiomyopathy1.50482330
57MP0003186_abnormal_redox_activity1.45987978
58MP0005253_abnormal_eye_physiology1.43926827
59MP0002184_abnormal_innervation1.43639599
60MP0004087_abnormal_muscle_fiber1.43032637
61MP0002269_muscular_atrophy1.42939382
62MP0005174_abnormal_tail_pigmentation1.42802655
63MP0008872_abnormal_physiological_respon1.42202273
64MP0002909_abnormal_adrenal_gland1.41566818
65MP0009785_altered_susceptibility_to1.41307619
66MP0003122_maternal_imprinting1.40305942
67MP0004924_abnormal_behavior1.39027800
68MP0005386_behavior/neurological_phenoty1.39027800
69MP0004085_abnormal_heartbeat1.38455895
70MP0002148_abnormal_hypersensitivity_rea1.37370023
71MP0002332_abnormal_exercise_endurance1.37178583
72MP0002972_abnormal_cardiac_muscle1.35633623
73MP0004142_abnormal_muscle_tone1.35097939
74MP0009780_abnormal_chondrocyte_physiolo1.32947539
75MP0003137_abnormal_impulse_conducting1.32018819
76MP0001486_abnormal_startle_reflex1.31832230
77MP0005646_abnormal_pituitary_gland1.28639085
78MP0002138_abnormal_hepatobiliary_system1.26618358
79MP0001905_abnormal_dopamine_level1.26347899
80MP0005671_abnormal_response_to1.26331601
81MP0000015_abnormal_ear_pigmentation1.25990279
82MP0001502_abnormal_circadian_rhythm1.18559179
83MP0004885_abnormal_endolymph1.18532120
84MP0000427_abnormal_hair_cycle1.17479406
85MP0005379_endocrine/exocrine_gland_phen1.16768846
86MP0002557_abnormal_social/conspecific_i1.12291850
87MP0002693_abnormal_pancreas_physiology1.10941264
88MP0009764_decreased_sensitivity_to1.10682861
89MP0000778_abnormal_nervous_system1.08803171
90MP0003786_premature_aging1.06588532
91MP0006054_spinal_hemorrhage1.05223444
92MP0005167_abnormal_blood-brain_barrier1.05034279
93MP0006072_abnormal_retinal_apoptosis1.04049343
94MP0008569_lethality_at_weaning1.04024105
95MP0003329_amyloid_beta_deposits1.03272143
96MP0002066_abnormal_motor_capabilities/c1.03127105
97MP0001919_abnormal_reproductive_system1.01127408
98MP0002638_abnormal_pupillary_reflex0.99973751
99MP0001986_abnormal_taste_sensitivity0.99224591
100MP0000750_abnormal_muscle_regeneration0.98926175
101MP0003656_abnormal_erythrocyte_physiolo0.98845681
102MP0005535_abnormal_body_temperature0.96547783
103MP0001835_abnormal_antigen_presentation0.96136493
104MP0006082_CNS_inflammation0.96003296
105MP0005389_reproductive_system_phenotype0.94213590
106MP0001188_hyperpigmentation0.94014503
107MP0000955_abnormal_spinal_cord0.93366440
108MP0004043_abnormal_pH_regulation0.93322862
109MP0008775_abnormal_heart_ventricle0.92883059
110MP0005332_abnormal_amino_acid0.92654855
111MP0003879_abnormal_hair_cell0.90545104
112MP0005423_abnormal_somatic_nervous0.90526439
113MP0003950_abnormal_plasma_membrane0.90123202
114MP0004811_abnormal_neuron_physiology0.89377009
115MP0006035_abnormal_mitochondrial_morpho0.87607121
116MP0001764_abnormal_homeostasis0.87340597
117MP0002095_abnormal_skin_pigmentation0.87169995
118MP0002882_abnormal_neuron_morphology0.85898386
119MP0005636_abnormal_mineral_homeostasis0.84112135
120MP0003221_abnormal_cardiomyocyte_apopto0.83421994
121MP0005266_abnormal_metabolism0.82270516
122MP0008875_abnormal_xenobiotic_pharmacok0.82101262
123MP0005387_immune_system_phenotype0.81587818
124MP0001790_abnormal_immune_system0.81587818
125MP0005385_cardiovascular_system_phenoty0.81057841
126MP0001544_abnormal_cardiovascular_syste0.81057841
127MP0005410_abnormal_fertilization0.81014713
128MP0003633_abnormal_nervous_system0.80475390
129MP0001756_abnormal_urination0.78825329
130MP0002090_abnormal_vision0.78237696
131MP0009697_abnormal_copulation0.78173605
132MP0000685_abnormal_immune_system0.78101606
133MP0003121_genomic_imprinting0.77812603
134MP0002108_abnormal_muscle_morphology0.76892973
135MP0003195_calcinosis0.76880715
136MP0004742_abnormal_vestibular_system0.76590940
137MP0005000_abnormal_immune_tolerance0.75839177
138MP0000230_abnormal_systemic_arterial0.73426177
139MP0001485_abnormal_pinna_reflex0.69628631
140MP0002876_abnormal_thyroid_physiology0.69323331
141MP0010386_abnormal_urinary_bladder0.69023129
142MP0006138_congestive_heart_failure0.67865949
143MP0003787_abnormal_imprinting0.65828420
144MP0002069_abnormal_eating/drinking_beha0.64453099
145MP0002751_abnormal_autonomic_nervous0.64113699
146MP0002234_abnormal_pharynx_morphology0.63705000
147MP0008874_decreased_physiological_sensi0.63579058
148MP0002078_abnormal_glucose_homeostasis0.62463952
149MP0008995_early_reproductive_senescence0.59717328
150MP0002752_abnormal_somatic_nervous0.58132090
151MP0000631_abnormal_neuroendocrine_gland0.57944758
152MP0009250_abnormal_appendicular_skeleto0.55342423
153MP0002971_abnormal_brown_adipose0.54758796

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.81540008
2Muscle hypertrophy of the lower extremities (HP:0008968)4.69465158
3Focal motor seizures (HP:0011153)4.42751071
4Acute necrotizing encephalopathy (HP:0006965)4.39203667
5Calf muscle hypertrophy (HP:0008981)4.36364082
6Exercise-induced muscle cramps (HP:0003710)4.32802913
7Muscle fiber inclusion bodies (HP:0100299)4.20562123
8Abnormal mitochondria in muscle tissue (HP:0008316)4.14861144
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.00818680
10Pheochromocytoma (HP:0002666)3.84250739
11Progressive macrocephaly (HP:0004481)3.82466185
12Nemaline bodies (HP:0003798)3.78889485
13Atonic seizures (HP:0010819)3.70769896
14Neuroendocrine neoplasm (HP:0100634)3.65826633
15Acute encephalopathy (HP:0006846)3.57561911
16Myotonia (HP:0002486)3.43899597
17Sudden death (HP:0001699)3.38089520
18Stomatitis (HP:0010280)3.35780022
19Abnormality of the calf musculature (HP:0001430)3.33230572
20Mitochondrial inheritance (HP:0001427)3.31098077
21Myoglobinuria (HP:0002913)3.26448855
22Distal arthrogryposis (HP:0005684)3.20968091
23Methylmalonic acidemia (HP:0002912)3.18461649
24Muscle fiber splitting (HP:0003555)3.16630896
25Myokymia (HP:0002411)3.04896790
26Febrile seizures (HP:0002373)2.90246990
27Pancreatic cysts (HP:0001737)2.87664787
28Congenital, generalized hypertrichosis (HP:0004540)2.85941298
29Muscle stiffness (HP:0003552)2.84658638
30Epileptic encephalopathy (HP:0200134)2.84383296
31Abnormality of the renal cortex (HP:0011035)2.83431941
32Increased CSF lactate (HP:0002490)2.82710667
33EMG: myopathic abnormalities (HP:0003458)2.80969530
34Congenital sensorineural hearing impairment (HP:0008527)2.79021792
35Hyporeflexia of lower limbs (HP:0002600)2.77357424
36Absence seizures (HP:0002121)2.72109849
373-Methylglutaconic aciduria (HP:0003535)2.70072287
38Type 1 muscle fiber predominance (HP:0003803)2.68613712
39Visual hallucinations (HP:0002367)2.62077565
40Pancreatic fibrosis (HP:0100732)2.62076646
41Congenital stationary night blindness (HP:0007642)2.60938055
42Hyperventilation (HP:0002883)2.60781969
43Hepatocellular necrosis (HP:0001404)2.57287404
44Molar tooth sign on MRI (HP:0002419)2.57131454
45Abnormality of midbrain morphology (HP:0002418)2.57131454
46Oligomenorrhea (HP:0000876)2.56406307
47Exercise intolerance (HP:0003546)2.54964464
48Palpitations (HP:0001962)2.54656740
49Cerebral edema (HP:0002181)2.52997455
50Rimmed vacuoles (HP:0003805)2.49834802
51Focal seizures (HP:0007359)2.49791585
52Renal cortical cysts (HP:0000803)2.49041960
53Gait imbalance (HP:0002141)2.46687107
54True hermaphroditism (HP:0010459)2.44303457
55Myopathic facies (HP:0002058)2.43616355
56Exertional dyspnea (HP:0002875)2.42921928
57Methylmalonic aciduria (HP:0012120)2.42722007
58Metaphyseal dysplasia (HP:0100255)2.38846196
59Hyperinsulinemic hypoglycemia (HP:0000825)2.38333526
60Hypothermia (HP:0002045)2.38198570
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.36905028
62Abnormality of alanine metabolism (HP:0010916)2.36905028
63Hyperalaninemia (HP:0003348)2.36905028
64Dialeptic seizures (HP:0011146)2.33732064
65Hypochromic microcytic anemia (HP:0004840)2.33253695
66Left ventricular hypertrophy (HP:0001712)2.33224832
67Hepatic necrosis (HP:0002605)2.32552518
68Congenital primary aphakia (HP:0007707)2.32327186
69Optic disc pallor (HP:0000543)2.31907412
70Shoulder girdle muscle weakness (HP:0003547)2.30887819
71Abnormality of vitamin B metabolism (HP:0004340)2.26442589
72Medial flaring of the eyebrow (HP:0010747)2.26348704
73Difficulty running (HP:0009046)2.25782349
74Nephronophthisis (HP:0000090)2.25222689
75Absent phalangeal crease (HP:0006109)2.24957925
76Generalized tonic-clonic seizures (HP:0002069)2.24253035
77Thyroiditis (HP:0100646)2.23916392
78Lactic acidosis (HP:0003128)2.23162933
79Neck muscle weakness (HP:0000467)2.21430690
80Round ear (HP:0100830)2.19301141
81Increased intramyocellular lipid droplets (HP:0012240)2.17406588
82Areflexia of lower limbs (HP:0002522)2.17034538
83Rhabdomyolysis (HP:0003201)2.16055762
84Anxiety (HP:0000739)2.13262111
85Renal Fanconi syndrome (HP:0001994)2.12917983
86Broad-based gait (HP:0002136)2.12327504
87Syncope (HP:0001279)2.10633576
88Abnormal ciliary motility (HP:0012262)2.10226725
89Abnormality of the renal medulla (HP:0100957)2.10141240
90Progressive inability to walk (HP:0002505)2.07014217
91Fetal akinesia sequence (HP:0001989)2.04597021
92Albinism (HP:0001022)2.04587544
93Increased muscle lipid content (HP:0009058)2.04388708
94Abnormality of urine glucose concentration (HP:0011016)2.02241241
95Glycosuria (HP:0003076)2.02241241
96Polydipsia (HP:0001959)2.01814189
97Abnormal drinking behavior (HP:0030082)2.01814189
98Respiratory failure (HP:0002878)1.99601096
99Abnormal rod and cone electroretinograms (HP:0008323)1.99373943
100Abnormality of glycolysis (HP:0004366)1.97301950
101Increased serum pyruvate (HP:0003542)1.97301950
102Hypoglycemic coma (HP:0001325)1.97287641
103Abnormality of the vitamin B12 metabolism (HP:0004341)1.97062417
104Large for gestational age (HP:0001520)1.96408612
105Nephrogenic diabetes insipidus (HP:0009806)1.96061312
106Abnormal respiratory motile cilium physiology (HP:0012261)1.93869050
107Abnormality of the musculature of the pelvis (HP:0001469)1.93619244
108Abnormality of the hip-girdle musculature (HP:0001445)1.93619244
109Ketosis (HP:0001946)1.93213222
110Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91826148
111X-linked dominant inheritance (HP:0001423)1.90805449
112Abnormal finger flexion creases (HP:0006143)1.90326595
113Ketoacidosis (HP:0001993)1.90275504
114Abnormality of renal resorption (HP:0011038)1.88576374
115Prolonged QT interval (HP:0001657)1.87840618
116Asymmetric septal hypertrophy (HP:0001670)1.87208878
117Progressive cerebellar ataxia (HP:0002073)1.87106705
118Increased serum lactate (HP:0002151)1.86748623
119Genital tract atresia (HP:0001827)1.85948588
120Neoplasm of the peripheral nervous system (HP:0100007)1.85919363
121Increased hepatocellular lipid droplets (HP:0006565)1.85463642
122Abnormal respiratory epithelium morphology (HP:0012253)1.85057768
123Abnormal respiratory motile cilium morphology (HP:0005938)1.85057768
124Abnormality of macular pigmentation (HP:0008002)1.84856441
125Vaginal atresia (HP:0000148)1.84842284
126Leukodystrophy (HP:0002415)1.84813558
127Primary atrial arrhythmia (HP:0001692)1.84776014
128Abnormal hair whorl (HP:0010721)1.84610317
129Atrial fibrillation (HP:0005110)1.83930742
130Abnormality of the left ventricular outflow tract (HP:0011103)1.83915691
131Subaortic stenosis (HP:0001682)1.83915691
132Tongue fasciculations (HP:0001308)1.83622034
133Aplasia/Hypoplasia of the fovea (HP:0008060)1.82917175
134Hypoplasia of the fovea (HP:0007750)1.82917175
135Conjunctival hamartoma (HP:0100780)1.82420179
136Fair hair (HP:0002286)1.82389670
137Ulnar deviation of the wrist (HP:0003049)1.82015477
138Lethargy (HP:0001254)1.81343573
139Lipid accumulation in hepatocytes (HP:0006561)1.80390878
140Muscle fibrillation (HP:0010546)1.79511775
141Poor suck (HP:0002033)1.79001613
142Increased variability in muscle fiber diameter (HP:0003557)1.78836543
143Disproportionate short-trunk short stature (HP:0003521)1.78469251
144Failure to thrive in infancy (HP:0001531)1.78281143
145Alveolar cell carcinoma (HP:0006519)1.77494089
146Hypoproteinemia (HP:0003075)1.76628631
147Furrowed tongue (HP:0000221)1.75309996
148Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.74499338
149Pancreatic islet-cell hyperplasia (HP:0004510)1.74429687
150Type II lissencephaly (HP:0007260)1.73242083
151Abnormality of the fovea (HP:0000493)1.73063130
152Hamartoma of the eye (HP:0010568)1.72531150
153Hypomagnesemia (HP:0002917)1.70921776
154Absent speech (HP:0001344)1.70414551
155Hematochezia (HP:0002573)1.68814777
156Neoplasm of the tracheobronchial system (HP:0100552)1.68627135
157Limb dystonia (HP:0002451)1.68314053
158Attenuation of retinal blood vessels (HP:0007843)1.65891960
159Polyuria (HP:0000103)1.65579410
160Constricted visual fields (HP:0001133)1.64788255
161Aplasia/hypoplasia of the uterus (HP:0008684)1.63685715
162Long clavicles (HP:0000890)1.62855406
163Cutaneous melanoma (HP:0012056)1.61752035
164Stomach cancer (HP:0012126)1.61748133
165Hyperglycemia (HP:0003074)1.60814109
166Generalized hypopigmentation of hair (HP:0011358)1.60546114
167Male pseudohermaphroditism (HP:0000037)1.60469464

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.95605950
2CASK3.39942884
3PHKG23.27716258
4PHKG13.27716258
5OBSCN3.14593255
6NME12.90432169
7MST42.89677398
8MAP3K122.76195844
9MAP3K42.56165182
10NTRK32.51128337
11NUAK12.46512485
12PINK12.43103035
13TRIM282.41985061
14MAP4K22.38377559
15MAP3K92.36947445
16MAP2K72.23301980
17ACVR1B2.17543372
18ARAF2.00899668
19TXK1.97649383
20MAPK151.97447384
21PDK41.96414838
22PDK31.96414838
23TAOK31.95993149
24MAP2K41.91360980
25EIF2AK31.90481004
26EPHA41.88976191
27GRK11.68132047
28CDK191.65135082
29MUSK1.59141589
30EIF2AK11.53918385
31MINK11.49331962
32DAPK21.48925908
33DAPK11.46942491
34TTN1.43419528
35UHMK11.41515336
36BRSK21.36217595
37KSR21.32420754
38GRK51.31388176
39CAMK2A1.21699069
40MARK11.18052810
41MAPK131.17690059
42MAP3K61.16023613
43MYLK1.15249877
44MAPKAPK31.12943529
45NLK1.09280655
46GRK71.07026623
47MAP2K61.06849566
48PNCK1.06821161
49CAMK2B1.06639573
50RIPK41.06513670
51CAMK2G1.06099503
52PDK21.05949266
53PLK21.03200092
54NTRK11.02027692
55CAMK2D1.00527352
56IRAK10.99725689
57KSR10.98724005
58BCR0.97154486
59MKNK20.94986624
60FGR0.94696951
61LIMK10.94490797
62OXSR10.93301699
63WNK40.93135902
64PIK3CG0.91527132
65AKT30.90979664
66PAK30.90323017
67CDK50.89569995
68PLK30.89392786
69PRPF4B0.87338979
70WNK30.87262612
71STK160.86748589
72IKBKB0.80584449
73PRKCG0.80221964
74MAP3K20.79881296
75BMPR20.79193192
76BRAF0.79060975
77MAPK120.78903990
78TNIK0.78638839
79PRKCE0.77280851
80DYRK1A0.77231119
81MARK30.77207891
82PAK60.76026666
83FGFR20.73577213
84NTRK20.71400930
85RAF10.71153142
86ERBB30.70555254
87MAP3K130.70407605
88DMPK0.69591708
89PTK2B0.69462407
90FER0.69161398
91MAP3K50.67040056
92MAP3K110.66892891
93PRKCQ0.65307226
94SGK4940.65233292
95SGK2230.65233292
96ZAK0.65056268
97TEC0.64983261
98IRAK20.64815090
99SIK30.63804714
100LMTK20.63711641
101BCKDK0.62268678
102MAP2K10.61464390
103VRK10.61148155
104CSNK1G10.61116018
105STK240.60347365
106PIK3CA0.60263186
107STK390.59457498
108STK30.58239718
109INSRR0.57638751
110CDK140.57050257
111TGFBR20.56153470
112MAP3K10.55924618
113TLK10.54899106
114BMPR1B0.54572792
115PKN10.51432758
116CCNB10.51146417
117PRKACA0.51075930
118ADRBK10.50958641
119SGK10.50151430
120MAP3K70.49282175
121SGK20.49009044
122TNK20.48863463
123IKBKE0.47936528
124CDK180.46912966
125CSNK1G20.46368862
126CSNK1G30.45631347
127DYRK20.45165927
128YES10.44052084
129WEE10.43918069
130PRKG10.43248057
131PLK40.42668565
132CAMKK20.40302439
133CDK150.40195499
134TRPM70.39665909
135DYRK1B0.39234447
136TAOK20.38548481
137NEK10.38137460
138ADRBK20.37982020
139LATS20.36676762
140TGFBR10.35690786
141ROCK10.34819249
142CDK11A0.34776056
143FES0.33540560
144SYK0.32348429
145GRK60.31707944
146ITK0.30183995
147ABL10.30146733
148LYN0.28710438

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.04243700
2Parkinsons disease_Homo sapiens_hsa050123.47660198
3Cardiac muscle contraction_Homo sapiens_hsa042602.94201220
4Alzheimers disease_Homo sapiens_hsa050102.83559360
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.82109135
6Nicotine addiction_Homo sapiens_hsa050332.52768589
7Synaptic vesicle cycle_Homo sapiens_hsa047212.51192592
8Collecting duct acid secretion_Homo sapiens_hsa049662.47393837
9Huntingtons disease_Homo sapiens_hsa050162.30366847
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.99755042
11GABAergic synapse_Homo sapiens_hsa047271.97808773
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.95775013
13Olfactory transduction_Homo sapiens_hsa047401.92571471
14Amphetamine addiction_Homo sapiens_hsa050311.90294928
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85665414
16Circadian entrainment_Homo sapiens_hsa047131.82015051
17Long-term potentiation_Homo sapiens_hsa047201.76244552
18Nitrogen metabolism_Homo sapiens_hsa009101.73591687
19Morphine addiction_Homo sapiens_hsa050321.60864797
20Dopaminergic synapse_Homo sapiens_hsa047281.60605686
21Circadian rhythm_Homo sapiens_hsa047101.60117567
22Vibrio cholerae infection_Homo sapiens_hsa051101.60053788
23Calcium signaling pathway_Homo sapiens_hsa040201.56747375
24Basal transcription factors_Homo sapiens_hsa030221.54544567
25Taste transduction_Homo sapiens_hsa047421.54123678
26Insulin secretion_Homo sapiens_hsa049111.53749638
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.53051812
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50669000
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.48709291
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47154500
31Serotonergic synapse_Homo sapiens_hsa047261.46005305
32Oxytocin signaling pathway_Homo sapiens_hsa049211.45289615
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43479380
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43238130
35Renin secretion_Homo sapiens_hsa049241.39255676
36Glutamatergic synapse_Homo sapiens_hsa047241.38330796
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38192203
38RNA degradation_Homo sapiens_hsa030181.35718155
39Dilated cardiomyopathy_Homo sapiens_hsa054141.34626317
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32005599
41Long-term depression_Homo sapiens_hsa047301.27163973
42Type I diabetes mellitus_Homo sapiens_hsa049401.25986956
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.23296901
44Pyruvate metabolism_Homo sapiens_hsa006201.23044083
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22441871
46Propanoate metabolism_Homo sapiens_hsa006401.21757241
47Salivary secretion_Homo sapiens_hsa049701.18889168
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18343898
49RNA polymerase_Homo sapiens_hsa030201.17771344
50Gastric acid secretion_Homo sapiens_hsa049711.16754911
51Cholinergic synapse_Homo sapiens_hsa047251.13019293
52Legionellosis_Homo sapiens_hsa051341.12431016
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11619686
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11611001
55Peroxisome_Homo sapiens_hsa041461.11284957
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09908145
57Linoleic acid metabolism_Homo sapiens_hsa005911.07609649
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05074448
59Cocaine addiction_Homo sapiens_hsa050301.04901179
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.04285571
61Tryptophan metabolism_Homo sapiens_hsa003801.03094863
62Glucagon signaling pathway_Homo sapiens_hsa049221.01908490
63GnRH signaling pathway_Homo sapiens_hsa049121.01906570
64Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01824360
65Butanoate metabolism_Homo sapiens_hsa006501.01719494
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99285792
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98396905
68Ether lipid metabolism_Homo sapiens_hsa005650.97025608
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94903341
70Mineral absorption_Homo sapiens_hsa049780.94149634
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92666051
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91233951
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91120583
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88244843
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86423577
76cAMP signaling pathway_Homo sapiens_hsa040240.85234222
77Gap junction_Homo sapiens_hsa045400.85125452
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.85003703
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82003503
80Regulation of autophagy_Homo sapiens_hsa041400.81284346
81Folate biosynthesis_Homo sapiens_hsa007900.77906754
82Insulin signaling pathway_Homo sapiens_hsa049100.77510146
83Chemical carcinogenesis_Homo sapiens_hsa052040.75851692
84Caffeine metabolism_Homo sapiens_hsa002320.74868837
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.72127254
86Fatty acid elongation_Homo sapiens_hsa000620.71362810
87Graft-versus-host disease_Homo sapiens_hsa053320.70972676
88Allograft rejection_Homo sapiens_hsa053300.69970805
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67163480
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66244405
91Melanogenesis_Homo sapiens_hsa049160.65826559
92Fatty acid metabolism_Homo sapiens_hsa012120.62824206
93Autoimmune thyroid disease_Homo sapiens_hsa053200.62461784
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62174604
95Primary immunodeficiency_Homo sapiens_hsa053400.61622212
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.61203990
97Carbon metabolism_Homo sapiens_hsa012000.60474208
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60447726
99Selenocompound metabolism_Homo sapiens_hsa004500.58372587
100Hematopoietic cell lineage_Homo sapiens_hsa046400.57936174
101Fatty acid biosynthesis_Homo sapiens_hsa000610.57853766
102Rheumatoid arthritis_Homo sapiens_hsa053230.56155506
103Glutathione metabolism_Homo sapiens_hsa004800.55674529
104Protein export_Homo sapiens_hsa030600.54029353
105Sulfur metabolism_Homo sapiens_hsa009200.53693864
106Purine metabolism_Homo sapiens_hsa002300.53482230
107Arachidonic acid metabolism_Homo sapiens_hsa005900.53243733
108Pancreatic secretion_Homo sapiens_hsa049720.53184109
109MAPK signaling pathway_Homo sapiens_hsa040100.52677244
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52460277
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49877259
112Fatty acid degradation_Homo sapiens_hsa000710.49490700
113Fanconi anemia pathway_Homo sapiens_hsa034600.49473075
114Phototransduction_Homo sapiens_hsa047440.48057855
115ErbB signaling pathway_Homo sapiens_hsa040120.47195492
116Oocyte meiosis_Homo sapiens_hsa041140.45575111
117Estrogen signaling pathway_Homo sapiens_hsa049150.45037837
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44420245
119Homologous recombination_Homo sapiens_hsa034400.43695716
120Starch and sucrose metabolism_Homo sapiens_hsa005000.43139724
121Steroid biosynthesis_Homo sapiens_hsa001000.42926998
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42291096
123Axon guidance_Homo sapiens_hsa043600.41399017
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41367664
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41319827
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38782265
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37952129
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37784503
129African trypanosomiasis_Homo sapiens_hsa051430.37741814
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37672870
131Malaria_Homo sapiens_hsa051440.37473941
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37380146
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.36288223
134Retinol metabolism_Homo sapiens_hsa008300.35026282
135Type II diabetes mellitus_Homo sapiens_hsa049300.34702729
136beta-Alanine metabolism_Homo sapiens_hsa004100.34590988
137Ras signaling pathway_Homo sapiens_hsa040140.33710201
138Proteasome_Homo sapiens_hsa030500.33255595
139Dorso-ventral axis formation_Homo sapiens_hsa043200.32720963
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31746254
141Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.31147752
142Non-homologous end-joining_Homo sapiens_hsa034500.30930732
143AMPK signaling pathway_Homo sapiens_hsa041520.30490494
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30257320
145Phagosome_Homo sapiens_hsa041450.28001333
146Maturity onset diabetes of the young_Homo sapiens_hsa049500.27651187
147Phenylalanine metabolism_Homo sapiens_hsa003600.27467718
148Measles_Homo sapiens_hsa051620.27031619
149Arginine and proline metabolism_Homo sapiens_hsa003300.26740266
150VEGF signaling pathway_Homo sapiens_hsa043700.26146979
151Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26142937
152Tight junction_Homo sapiens_hsa045300.25649697
153Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25344564
154Metabolic pathways_Homo sapiens_hsa011000.24611527

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